What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Adverse Neurologic Effects of Medications Commonly Used in the Intensive Care Unit. | Voils SA, Human T, Brophy GM | Critical care clinics | 2014 | |
| Estimating the effect of incident delirium on short-term outcomes in aged hip fracture patients through propensity score analysis. | Radinovic K, Markovic-Denic L, Dubljanin-Raspopovic E, Marinkovic J, Milan Z, Bumbasirevic V | Geriatrics & gerontology international | 2015 | |
| The Mini-Mental State Examination as a diagnostic and screening test for delirium: systematic review and meta-analysis. | Mitchell AJ, Shukla D, Ajumal HA, Stubbs B, Tahir TA | General hospital psychiatry | 2014 | |
| Adverse consequences of glucocorticoid medication: psychological, cognitive, and behavioral effects. | Judd LL, Schettler PJ, Brown ES, Wolkowitz OM, Sternberg EM, Bender BG, Bulloch K, Cidlowski JA, Ronald de Kloet E, Fardet L, Joëls M, Leung DY, McEwen BS, Roozendaal B, Van Rossum EF, Ahn J, Brown DW, Plitt A, Singh G | The American journal of psychiatry | 2014 | |
| A multifaceted intervention package to improve the diagnosis and management of delirium. | Fleet J, Chen S, Martin FC, Ernst T | International psychogeriatrics / IPA | 2014 | |
| Improvement of care for ICU patients with delirium by early screening and treatment: study protocol of iDECePTIvE study. | Ista E, Trogrlic Z, Bakker J, Osse R, van Achterberg T, van der Jagt M | Implementation science : IS | 2014 | |
| Outcomes after delirium in a Japanese intensive care unit. | Yamaguchi T, Tsukioka E, Kishi Y | General hospital psychiatry | 2014 | |
| Arterial pressure above the upper cerebral autoregulation limit during cardiopulmonary bypass is associated with postoperative delirium. | Hori D, Brown C, Ono M, Rappold T, Sieber F, Gottschalk A, Neufeld KJ, Gottesman R, Adachi H, Hogue CW | British journal of anaesthesia | 2014 |
Aged, Arterial Pressure, physiology, Cardiopulmonary Bypass, adverse effects, Cerebrovascular Circulation, physiology, Delirium, etiology, Female, Homeostasis, physiology, Humans, Male, Middle Aged, Monitoring, Intraoperative, methods, Perioperative Care, methods, Prospective Studies, Risk Factors, Spectroscopy, Near-Infrared, methods |
| Postoperative Delirium: Risk Factors, Prevention, and Treatment. | Trabold B, Metterlein T | Journal of cardiothoracic and vascular anesthesia | 2014 | |
| Anticholinergic drug use and negative outcomes among the frail elderly population living in a nursing home. | Landi F, Dell'Aquila G, Collamati A, Martone AM, Zuliani G, Gasperini B, Eusebi P, Lattanzio F, Cherubini A | Journal of the American Medical Directors Association | 2014 | |
| Experiences, understandings and support needs of family carers of older patients with delirium: a descriptive mixed methods study in a hospital delirium unit. | Toye C, Matthews A, Hill A, Maher S | International journal of older people nursing | 2014 | |
| Delirium in elderly patients hospitalized in internal medicine wards. | Fortini A, Morettini A, Tavernese G, Facchini S, Tofani L, Pazzi M | Internal and emergency medicine | 2014 |
Aged, Aged, 80 and over, Delirium, epidemiology, Female, Hospital Departments, Hospitalization, Humans, Incidence, Internal Medicine, Male, Prospective Studies, Risk Factors |
| Development and validation of a delirium predictive score in older people. | Carrasco MP, Villarroel L, Andrade M, Calderón J, González M | Age and ageing | 2014 |
Activities of Daily Living, psychology, Aged, Chile, epidemiology, Comorbidity, Decision Support Techniques, Dehydration, blood, Delirium, blood, Female, Geriatric Assessment, methods, Hospitalization, statistics & numerical data, Humans, Male, Prospective Studies, ROC Curve, Reproducibility of Results, Risk Assessment, methods, Risk Factors, Severity of Illness Index |
| Raised IL-2 and TNF-α concentrations are associated with postoperative delirium in patients undergoing coronary-artery bypass graft surgery. | Kazmierski J, Banys A, Latek J, Bourke J, Jaszewski R | International psychogeriatrics / IPA | 2014 |
Aged, Biological Markers, blood, Cardiopulmonary Bypass, adverse effects, Coronary Artery Bypass, adverse effects, Delirium, blood, Early Diagnosis, Female, Humans, Interleukin-2, blood, Male, Middle Aged, Monitoring, Physiologic, methods, Outcome Assessment (Health Care), Poland, Postoperative Complications, blood, Preoperative Care, methods, Prospective Studies, Psychiatric Status Rating Scales, Risk Assessment, Risk Factors, Tumor Necrosis Factor-alpha, blood |
| Nurse screening for delirium in older patients attending the emergency department. | Hare M, Arendts G, Wynaden D, Leslie G | Psychosomatics | 2014 | |
| Hospitalization and cognitive decline: Can the nature of the relationship be deciphered? | Mathews SB, Arnold SE, Epperson CN | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2014 | |
| Can improved intra- and inter-team communication reduce missed delirium? | Detweiler MB, Kenneth A, Bader G, Sullivan K, Murphy PF, Halling M, Kalafat N, Detweiler JG | The Psychiatric quarterly | 2014 | |
| Olanzapine postinjection delirium/sedation syndrome: an unrecognized diagnosis in the emergency department. | Vodovar D, Malissin I, Deye N, Baud FJ, Mégarbane B | The Journal of emergency medicine | 2014 | |
| A multifaceted educational intervention to prevent delirium in older inpatients: a before and after study. | Wand AP, Thoo W, Sciuriaga H, Ting V, Baker J, Hunt GE | International journal of nursing studies | 2014 |
Aged, Aged, 80 and over, Delirium, prevention & control, Female, Humans, Inpatients, Inservice Training, organization & administration, Male, New South Wales |
| Screening for delirium in the emergency department: a systematic review. | LaMantia MA, Messina FC, Hobgood CD, Miller DK | Annals of emergency medicine | 2014 |
Aged, Delirium, diagnosis, Emergency Service, Hospital, Geriatric Assessment, Humans, Mass Screening, Neuropsychological Tests |
| Delirium and coma evaluated in mechanically ventilated patients in the intensive care unit in Japan: a multi-institutional prospective observational study. | Tsuruta R, Oda Y, Shintani A, Nunomiya S, Hashimoto S, Nakagawa T, Oida Y, Miyazaki D, Yabe S, | Journal of critical care | 2014 | |
| Caring for cognitively impaired older patients in the general hospital: A qualitative analysis of similarities and differences between a specialist Medical and Mental Health Unit and standard care wards. | Goldberg SE, Whittamore KH, Pollock K, Harwood RH, Gladman JR | International journal of nursing studies | 2014 | |
| The effect of a multicomponent multidisciplinary bundle of interventions on sleep and delirium in medical and surgical intensive care patients. | Patel J, Baldwin J, Bunting P, Laha S | Anaesthesia | 2014 |
Adult, Aged, Delirium, prevention & control, Female, Humans, Intensive Care, Intensive Care Units, Lighting, Male, Middle Aged, Noise, prevention & control, Sleep Deprivation, prevention & control |
| [Methohexital for analgosedation of ventilated intensive care patients : prospective nonrandomized single center observational study on incidence of delirium]. | Volz D, Vogt A, Schütz M, Hopf HB | Der Anaesthesist | 2014 | |
| Delirium educational interventions should address negative attitudes and focus on promoting learning through practice. | Teodorczuk A, Mukaetova-Ladinska E | Journal of the American Geriatrics Society | 2014 |
Delirium, diagnosis, Health Personnel, education, Humans |
| EEG patterns compatible with nonconvulsive status epilepticus are common in elderly patients with delirium: a prospective study with continuous EEG monitoring. | Gilles N, Chantal D, Claire M, Keziah K, Thierry P, Benjamin L | Epilepsy & behavior : E&B | 2014 | |
| Duration of delirium and patient-centered outcomes: embracing the short- and long-term perspective. | Anderson BJ, Mikkelsen ME | Critical care medicine | 2014 |
Delirium |
| Clarifying the confusion surrounding drug-associated delirium in the ICU. | Devlin JW, Zaal IJ, Slooter AJ | Critical care medicine | 2014 |
Acute Lung Injury, drug therapy, Adrenal Cortex Hormones, adverse effects, Delirium, etiology, Female, Humans, Male, Respiration, Artificial |
| Incidence and risk factors of delirium in the elderly general surgical patient. | de Castro SM, Ünlü Ç, Tuynman JB, Honig A, van Wagensveld BA, Steller EP, Vrouenraets BC | American journal of surgery | 2014 |
Age Factors, Aged, Aged, 80 and over, Delirium, diagnosis, Female, General Surgery, Hospitalization, Humans, Incidence, Length of Stay, Logistic Models, Male, Middle Aged, Multivariate Analysis, Preoperative Period, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors, Surgical Procedures, Elective, Surgical Procedures, Operative |
| Delirium and the Family Caregiver: The Need for Evidence-based Education Interventions. | Carbone MK, Gugliucci MR | The Gerontologist | 2015 |
Adaptation, Psychological, Adult, Aged, Caregivers, Delirium, nursing, Family, Humans, Quality of Life, Social Support |
| Newly identified precipitating factors in mechanical ventilation-induced brain damage: implications for treating ICU delirium. | González-López A, Albaiceta GM, Talbot K | Expert review of neurotherapeutics | 2014 | |
| Gender differences in factors associated with delirium severity in older adults with dementia. | Kolanowski AM, Hill NL, Kurum E, Fick DM, Yevchak AM, Mulhall P, Clare L, Valenzuela M | Archives of psychiatric nursing | 2014 | |
| Length of red cell unit storage and risk for delirium after cardiac surgery. | Brown CH, Grega M, Selnes OA, McKhann GM, Shah AS, LaFlam A, Savage WJ, Frank SM, Hogue CW, Gottesman RF | Anesthesia and analgesia | 2014 |
Aged, Aged, 80 and over, Baltimore, Blood Banks, Blood Preservation, adverse effects, Cardiac Surgical Procedures, adverse effects, Cardiopulmonary Bypass, adverse effects, Case-Control Studies, Chi-Square Distribution, Coronary Artery Bypass, adverse effects, Delirium, diagnosis, Erythrocyte Transfusion, adverse effects, Female, Heart Valve Prosthesis Implantation, adverse effects, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Postoperative Hemorrhage, etiology, Prospective Studies, Risk Factors, Time Factors, Treatment Outcome, Vascular Surgical Procedures, adverse effects |
| Delirium and dementia with Lewy bodies: distinct diagnoses or part of the same spectrum? | Gore RL, Vardy ER, O'Brien JT | Journal of neurology, neurosurgery, and psychiatry | 2015 |
Accidental Falls, Affective Symptoms, complications, Biological Markers, blood, Brain, metabolism, Cognition Disorders, complications, Consciousness Disorders, complications, Delirium, blood, Delusions, complications, Functional Neuroimaging, Humans, Lewy Body Disease, blood, Movement Disorders, complications, Perceptual Disorders, complications, Sleep Disorders, complications, Syncope, complications |
| Preoperative assessment of the older patient: a narrative review. | Oresanya LB, Lyons WL, Finlayson E | JAMA | 2014 |
Aged, Aged, 80 and over, Decision Making, Frail Elderly, Geriatric Assessment, Humans, Informed Consent, Odds Ratio, Preoperative Period, Risk Assessment, Surgical Procedures, Operative, adverse effects |
| Postoperative delirium and pre-fracture disability predict 6-month mortality among the oldest old hip fracture patients. | Mazzola P, Bellelli G, Broggini V, Anzuini A, Corsi M, Berruti D, De Filippi F, Zatti G, Annoni G | Aging clinical and experimental research | 2015 | |
| Can an e-learning course improve nursing care for older people at risk of delirium: a stepped wedge cluster randomised trial. | van de Steeg L, IJkema R, Langelaan M, Wagner C | BMC geriatrics | 2014 |
Aged, Aged, 80 and over, Delirium, diagnosis, Education, Distance, methods, Female, Humans, Male, Netherlands, epidemiology, Nursing Care, standards, Nursing Staff, education, Quality Improvement, standards, Risk Factors |
| Delirium and high Fever are associated with subacute motor deterioration in Parkinson disease: a nested case-control study. | Umemura A, Oeda T, Tomita S, Hayashi R, Kohsaka M, Park K, Sugiyama H, Sawada H | PloS one | 2014 | |
| Inflammation biomarkers and delirium in critically ill patients. | Ritter C, Tomasi CD, Dal-Pizzol F, Pinto BB, Dyson A, de Miranda AS, Comim CM, Soares M, Teixeira AL, Quevedo J, Singer M | Critical care (London, England) | 2014 | |
| Geriatric Assessment as a Predictor of Delirium and Other Outcomes in Elderly Patients With Cancer. | Korc-Grodzicki B, Sun SW, Zhou Q, Iasonos A, Lu B, Root JC, Downey RJ, Tew WP | Annals of surgery | 2014 | |
| Duration of postoperative delirium is an independent predictor of 6-month mortality in older adults after hip fracture. | Bellelli G, Mazzola P, Morandi A, Bruni A, Carnevali L, Corsi M, Zatti G, Zambon A, Corrao G, Olofsson B, Gustafson Y, Annoni G | Journal of the American Geriatrics Society | 2014 |
Aged, 80 and over, Delirium, epidemiology, Female, Hip Fractures, mortality, Humans, Male, Postoperative Complications, epidemiology, Prognosis, Prospective Studies, Time Factors |
| Delirium in advanced cancer: screening for the incidence on admission to an inpatient hospice unit. | Rainsford S, Rosenberg JP, Bullen T | Journal of palliative medicine | 2014 | |
| Long-term outcome of delirium during intensive care unit stay in survivors of critical illness: a prospective cohort study. | Wolters AE, van Dijk D, Pasma W, Cremer OL, Looije MF, de Lange DW, Veldhuijzen DS, Slooter AJ | Critical care (London, England) | 2014 | |
| Impact of delirium and suture-less securement on accidental vascular catheter removal in the ICU. | Sundararajan K, Wills S, Chacko B, Kanabar G, O'Connor S, Deane AM | Anaesthesia and intensive care | 2014 |
Adolescent, Adult, Aged, Aged, 80 and over, Australia, epidemiology, Catheterization, Central Venous, instrumentation, Catheters, statistics & numerical data, Causality, Child, Child, Preschool, Delirium, epidemiology, Female, Humans, Incidence, Infant, Intensive Care, methods, Intensive Care Units, statistics & numerical data, Male, Middle Aged, Odds Ratio, Postoperative Complications, epidemiology, Prospective Studies, Risk Factors, Suture Techniques, instrumentation, Young Adult |
| Delirium, subsyndromal delirium, and cognitive changes in individuals undergoing elective coronary artery bypass graft surgery. | Li HC, Chen YS, Chiu MJ, Fu MC, Huang GH, Chen CC | The Journal of cardiovascular nursing | 2015 | |
| Delirium during Weaning from Mechanical Ventilation. | Leite MA, Osaku EF, Costa CR, Cândia MF, Toccolini B, Covatti C, Costa NL, Nogueira ST, Ogasawara SM, de Albuquerque CE, Pilatti CM, Piana PA, Jorge AC, Duarte PA | Critical care research and practice | 2014 | |
| INCOG recommendations for management of cognition following traumatic brain injury, part I: posttraumatic amnesia/delirium. | Ponsford J, Janzen S, McIntyre A, Bayley M, Velikonja D, Tate R, | The Journal of head trauma rehabilitation | 2014 | |
| Delirium Screening in Cardiac Surgery (DESCARD): a useful tool for nonpsychiatrists. | Krzych LJ, Wybraniec MT, Krupka-Matuszczyk I, Skrzypek M, Bochenek AA | The Canadian journal of cardiology | 2014 |
Age Factors, Aged, Algorithms, Blood Glucose, analysis, Body Weight, Brain Ischemia, epidemiology, Cardiovascular Surgical Procedures, Cohort Studies, Delirium, diagnosis, Diabetes Mellitus, epidemiology, Diagnostic and Statistical Manual of Mental Disorders, Erythrocyte Transfusion, Fasting, blood, Female, Humans, Hypertension, epidemiology, Male, Middle Aged, Postoperative Complications, diagnosis, Postoperative Period, Predictive Value of Tests, Preoperative Period, Proteins, analysis, ROC Curve, Risk Assessment, methods, Risk Factors, Sensitivity and Specificity |
| Pilot study on the European Portuguese version of the Confusion Assessment Method. | Martins S, Moldes P, Pinto-de-Sousa J, Conceição F, Paiva JA, Simões MR, Fernandes L | Acta neuropsychiatrica | 2014 | |
| Evaluation of preoperative geriatric assessment of elderly patients with colorectal carcinoma. A retrospective study. | Indrakusuma R, Dunker MS, Peetoom JJ, Schreurs WH | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology | 2015 | |
| C-reactive Protein Predicts Postoperative Delirium Following Vascular Surgery. | Pol RA, van Leeuwen BL, Izaks GJ, Reijnen MM, Visser L, Tielliu IF, Zeebregts CJ | Annals of vascular surgery | 2014 | |
| Untangling ICU delirium: is establishing its prevention in high-risk patients the final frontier? | van der Jagt M, Trogrlic Z, Ista E | Intensive care medicine | 2014 | |
| Post-operative delirium in elderly patients. | Vijayakumar B, Elango P, Ganessan R | Indian journal of anaesthesia | 2014 | |
| What are the factors associated with physical activity (PA) participation in community dwelling adults with dementia? A systematic review of PA correlates. | Stubbs B, Eggermont L, Soundy A, Probst M, Vandenbulcke M, Vancampfort D | Archives of gerontology and geriatrics | 2014 | |
| Dexmedetomidine reduces the risk of delirium, agitation and confusion in critically Ill patients: a meta-analysis of randomized controlled trials. | Pasin L, Landoni G, Nardelli P, Belletti A, Di Prima AL, Taddeo D, Isella F, Zangrillo A | Journal of cardiothoracic and vascular anesthesia | 2014 | |
| Six-month outcomes of co-occurring delirium, depression, and dementia in long-term care. | McCusker J, Cole MG, Voyer P, Monette J, Champoux N, Ciampi A, Vu M, Belzile E | Journal of the American Geriatrics Society | 2014 | |
| Sensitivity and specificity of the animal fluency test for predicting postoperative delirium. | Long LS, Wolpaw JT, Leung JM | Canadian journal of anaesthesia = Journal canadien d'anesthesie | 2014 | |
| Effectiveness of implementing a wake up and breathe program on sedation and delirium in the ICU. | Khan BA, Fadel WF, Tricker JL, Carlos WG, Farber MO, Hui SL, Campbell NL, Ely EW, Boustani MA | Critical care medicine | 2014 |
Adult, Aged, Clinical Protocols, Coma, prevention & control, Critical Illness, Deep Sedation, methods, Delirium, prevention & control, Female, Humans, Incidence, Intensive Care Units, Length of Stay, Male, Middle Aged, Respiration, Respiration, Artificial, methods |
| Prospective analysis of adverse events in surgical treatment of degenerative spondylolisthesis. | Kelly AM, Batke JN, Dea N, Hartig DP, Fisher CG, Street JT | The spine journal : official journal of the North American Spine Society | 2014 | |
| Hospital readmission after hip fracture. | Kates SL, Behrend C, Mendelson DA, Cram P, Friedman SM | Archives of orthopaedic and trauma surgery | 2015 | |
| Incidence of delirium following total joint replacement in older adults: a meta-analysis. | Scott JE, Mathias JL, Kneebone AC | General hospital psychiatry | 2015 | |
| Severity of delirium in the ICU is associated with short term cognitive impairment. A prospective cohort study. | Sakuramoto H, Subrina J, Unoki T, Mizutani T, Komatsu H | Intensive & critical care nursing : the official journal of the British Association of Critical Care Nurses | 2015 | |
| Impact of malnutrition on postoperative delirium development after on pump coronary artery bypass grafting. | Ringaitienė D, Gineitytė D, Vicka V, Žvirblis T, Šipylaitė J, Irnius A, Ivaškevičius J, Kačergius T | Journal of cardiothoracic surgery | 2015 | |
| Association of cumulative dose of haloperidol with next-day delirium in older medical ICU patients. | Pisani MA, Araujo KL, Murphy TE | Critical care medicine | 2015 |
APACHE, Age Factors, Aged, Aged, 80 and over, Cognition Disorders, complications, Delirium, chemically induced, Dose-Response Relationship, Drug, Female, Haloperidol, administration & dosage, Humans, Intensive Care Units, statistics & numerical data, Male, Middle Aged, Prospective Studies, Risk Factors, Sex Factors, Time Factors |
| The confusion assessment method for the intensive care unit in patients with cirrhosis. | Orman ES, Perkins A, Ghabril M, Khan BA, Chalasani N, Boustani MA | Metabolic brain disease | 2015 | |
| In geriatric patients, delirium symptoms are related to the anticholinergic burden. | Naja M, Zmudka J, Hannat S, Liabeuf S, Serot JM, Jouanny P | Geriatrics & gerontology international | 2015 | |
| The impact of lymphopenia on delirium in ICU patients. | Inoue S, Vasilevskis EE, Pandharipande PP, Girard TD, Graves AJ, Thompson J, Shintani A, Ely EW | PloS one | 2015 | |
| Neuropsychological profiles of an elderly cohort undergoing elective surgery and the relationship between cognitive performance and delirium. | Fong TG, Hshieh TT, Wong B, Tommet D, Jones RN, Schmitt EM, Puelle MR, Saczynski JS, Marcantonio ER, Inouye SK | Journal of the American Geriatrics Society | 2015 | |
| Influence of intraoperative cerebral oximetry monitoring on neurocognitive function after coronary artery bypass surgery: a randomized, prospective study. | Colak Z, Borojevic M, Bogovic A, Ivancan V, Biocina B, Majeric-Kogler V | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery | 2015 | |
| Pre-surgical Geriatric Syndromes, Frailty, and Risks for Postoperative Delirium in Older Patients Undergoing Gastrointestinal Surgery: Prevalence and Red Flags. | Chen CC, Lin MT, Liang JT, Chen CM, Yen CJ, Huang GH | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract | 2015 | |
| Subsyndromal delirium after cardiac surgery. | Breu A, Stransky M, Metterlein T, Werner T, Trabold B | Scandinavian cardiovascular journal : SCJ | 2015 | |
| Stability of postoperative delirium psychomotor subtypes in individuals with hip fracture. | Albrecht JS, Marcantonio ER, Roffey DM, Orwig D, Magaziner J, Terrin M, Carson JL, Barr E, Brown JP, Gentry EG, Gruber-Baldini AL, | Journal of the American Geriatrics Society | 2015 | |
| Relationship between neurological complications, cerebrovascular and cerebral perfusion following off-pump coronary artery bypass grafting. | Xu B, Qiao Q, Chen M, Rastogi R, Luo D, Bi Q | Neurological research | 2015 | |
| Delayed sequence intubation: a prospective observational study. | Weingart SD, Trueger NS, Wong N, Scofi J, Singh N, Rudolph SS | Annals of emergency medicine | 2015 | |
| Multinational development and validation of an early prediction model for delirium in ICU patients. | Wassenaar A, van den Boogaard M, van Achterberg T, Slooter AJ, Kuiper MA, Hoogendoorn ME, Simons KS, Maseda E, Pinto N, Jones C, Luetz A, Schandl A, Verbrugghe W, Aitken LM, van Haren FM, Donders AR, Schoonhoven L, Pickkers P | Intensive care medicine | 2015 | |
| Association between intraoperative blood pressure and postoperative delirium in elderly hip fracture patients. | Wang NY, Hirao A, Sieber F | PloS one | 2015 | |
| Recognizing acute delirium as part of your routine [RADAR]: a validation study. | Voyer P, Champoux N, Desrosiers J, Landreville P, McCusker J, Monette J, Savoie M, Richard S, Carmichael PH | BMC nursing | 2015 | |
| A systematic review of implementation strategies for assessment, prevention, and management of ICU delirium and their effect on clinical outcomes. | Trogrlić Z, van der Jagt M, Bakker J, Balas MC, Ely EW, van der Voort PH, Ista E | Critical care (London, England) | 2015 |
Clinical Trials as Topic, methods, Critical Care, methods, Delirium, diagnosis, Disease Management, Humans, Intensive Care Units, Treatment Outcome |
| Intraoperative burst suppression is associated with postoperative delirium following cardiac surgery: a prospective, observational study. | Soehle M, Dittmann A, Ellerkmann RK, Baumgarten G, Putensen C, Guenther U | BMC anesthesiology | 2015 | |
| Clinical effectiveness of a sedation protocol minimizing benzodiazepine infusions and favoring early dexmedetomidine: a before-after study. | Skrupky LP, Drewry AM, Wessman B, Field RR, Fagley RE, Varghese L, Lieu A, Olatunde J, Micek ST, Kollef MH, Boyle WA | Critical care (London, England) | 2015 | |
| Pharmacologic prevention and treatment of delirium in intensive care patients: A systematic review. | Serafim RB, Bozza FA, Soares M, do Brasil PE, Tura BR, Ely EW, Salluh JI | Journal of critical care | 2015 | |
| Postoperative delirium in elderly after elective and acute colorectal surgery: A Prospective Cohort Study. | Raats JW, Steunenberg SL, Crolla RM, Wijsman JH, Slaa AT, van der Laan L | International journal of surgery (London, England) | 2015 | |
| Validation study of the European Portuguese version of the Confusion Assessment Method (CAM). | Martins S, Lourenço C, Pinto-de-Sousa J, Conceição F, Paiva JA, Simões MR, Fernandes L | International psychogeriatrics / IPA | 2015 | |
| Neurocognitive dysfunction risk alleviation with the use of dexmedetomidine in perioperative conditions or as ICU sedation: a meta-analysis. | Li B, Wang H, Wu H, Gao C | Medicine | 2015 | |
| Incidence and Risk Factors for Delirium among Mechanically Ventilated Patients in an African Intensive Care Setting: An Observational Multicenter Study. | Kwizera A, Nakibuuka J, Ssemogerere L, Sendikadiwa C, Obua D, Kizito S, Tumukunde J, Wabule A, Nakasujja N | Critical care research and practice | 2015 | |
| Implications of atypical antipsychotic prescribing in the intensive care unit. | Kram BL, Kram SJ, Brooks KR | Journal of critical care | 2015 | |
| The Mortality Risk of Conventional Antipsychotics in Elderly Patients: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials. | Hulshof TA, Zuidema SU, Ostelo RW, Luijendijk HJ | Journal of the American Medical Directors Association | 2015 | |
| Acute symptomatic complications among patients with advanced cancer admitted to acute palliative care units: A prospective observational study. | Hui D, Dos Santos R, Reddy S, Nascimento MS, Zhukovsky DS, Paiva CE, Dalal S, Costa ED, Walker P, Scapulatempo HH, Dev R, Crovador CS, De La Cruz M, Bruera E | Palliative medicine | 2015 | |
| Characteristics of older adults admitted to the emergency department (ED) and their risk factors for ED readmission based on comprehensive geriatric assessment: a prospective cohort study. | Deschodt M, Devriendt E, Sabbe M, Knockaert D, Deboutte P, Boonen S, Flamaing J, Milisen K | BMC geriatrics | 2015 |
Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Belgium, Comorbidity, Delirium, complications, Emergency Service, Hospital, Female, Geriatric Assessment, Hospitals, University, Humans, Male, Nutritional Status, Patient Discharge, Patient Readmission, Prospective Studies, Risk Factors, Time Factors |
| Hospital Elder Life Program in the real world: the many uses of the Hospital Elder Life Program website. | Chen P, Dowal S, Schmitt E, Habtemariam D, Hshieh TT, Victor R, Boockvar KS, Inouye SK | Journal of the American Geriatrics Society | 2015 | |
| Brain atrophy and white-matter hyperintensities are not significantly associated with incidence and severity of postoperative delirium in older persons without dementia. | Cavallari M, Hshieh TT, Guttmann CR, Ngo LH, Meier DS, Schmitt EM, Marcantonio ER, Jones RN, Kosar CM, Fong TG, Press D, Inouye SK, Alsop DC, | Neurobiology of aging | 2015 | |
| Psychometric Properties of the Family Caregiver Delirium Knowledge Questionnaire. | Bull MJ, Avery JS, Boaz L, Oswald D | Research in gerontological nursing | 2015 |
Adult, Aged, Aged, 80 and over, Caregivers, education, Cross-Sectional Studies, Delirium, diagnosis, Female, Health Knowledge, Attitudes, Practice, Home Nursing, education, Humans, Male, Middle Aged, Psychometrics, instrumentation, Questionnaires, Reproducibility of Results, Wisconsin, Young Adult |
| Delirium and other clinical factors with Clostridium difficile infection that predict mortality in hospitalized patients. | Archbald-Pannone LR, McMurry TL, Guerrant RL, Warren CA | American journal of infection control | 2015 | |
| What does delirium cost? : An economic evaluation of hyperactive delirium. | Weinrebe W, Johannsdottir E, Karaman M, Füsgen I | Zeitschrift fur Gerontologie und Geriatrie | 2016 | |
| Predicting postoperative delirium after vascular surgical procedures. | Visser L, Prent A, van der Laan MJ, van Leeuwen BL, Izaks GJ, Zeebregts CJ, Pol RA | Journal of vascular surgery | 2015 |
Aged, Aged, 80 and over, Amputation, adverse effects, Aorta, surgery, Chi-Square Distribution, Cognition Disorders, complications, Databases, Factual, Delirium, diagnosis, Elective Surgical Procedures, Female, Humans, Incidence, Logistic Models, Male, Middle Aged, Multivariate Analysis, Netherlands, Odds Ratio, Prospective Studies, Risk Assessment, Risk Factors, Treatment Outcome, Vascular Surgical Procedures, adverse effects |
| Development of a smartphone application for the objective detection of attentional deficits in delirium. | Tieges Z, Stíobhairt A, Scott K, Suchorab K, Weir A, Parks S, Shenkin S, MacLullich A | International psychogeriatrics / IPA | 2015 | |
| Association of point prevalence diagnosis of delirium on length of stay, 6-month mortality, and level of care on discharge at Waitemata District Health Board, Auckland. | Tan AH, Scott J | The New Zealand medical journal | 2015 |
Aged, Aged, 80 and over, Delirium, epidemiology, Humans, Institutionalization, statistics & numerical data, Length of Stay, Medical Audit, New Zealand, Patient Discharge, Prevalence |
| The prevalence, risk factors and short-term outcomes of delirium in Thai elderly emergency department patients. | Sri-On J, Tirrell GP, Vanichkulbodee A, Niruntarai S, Liu SW | Emergency medicine journal : EMJ | 2016 | |
| The impact of a delirium educational intervention with intensive care unit nurses. | Speed G | Clinical nurse specialist CNS | 2015 | |
| Preoperative cognitive intervention reduces cognitive dysfunction in elderly patients after gastrointestinal surgery: a randomized controlled trial. | Saleh AJ, Tang GX, Hadi SM, Yan L, Chen MH, Duan KM, Tong J, Ouyang W | Medical science monitor : international medical journal of experimental and clinical research | 2015 |