What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
Title | Authors | Journal | Year | Keywords |
---|---|---|---|---|
Perioperative urinary retention, short-term functional outcome and mortality rates of elderly hip fracture patients. | Adunsky A, Nenaydenko O, Koren-Morag N, Puritz L, Fleissig Y, Arad M | Geriatrics & gerontology international | 2015 | |
A comparison of delirium diagnosis in elderly medical inpatients using the CAM, DRS-R98, DSM-IV and DSM-5 criteria. | Adamis D, Rooney S, Meagher D, Mulligan O, McCarthy G | International psychogeriatrics / IPA | 2015 | |
Pharmacologic agents for the prevention and treatment of delirium in patients undergoing cardiac surgery: systematic review and metaanalysis. | Mu JL, Lee A, Joynt GM | Critical care medicine | 2015 |
Adult, Cardiac Surgical Procedures, adverse effects, Delirium, drug therapy, Humans, Length of Stay |
Efficacy and safety of dexmedetomidine for postoperative delirium in adult cardiac surgery on cardiopulmonary bypass. | Park JB, Bang SH, Chee HK, Kim JS, Lee SA, Shin JK | The Korean journal of thoracic and cardiovascular surgery | 2014 | |
Delirium in critically ill patients in a tertiary care centre in western region of Nepal. | Thapa P, Chakrabortty PK, Khattri JB, Ramesh K, Sharma P | Kathmandu University medical journal (KUMJ) | 2014 |
Critical Illness, psychology, Cross-Sectional Studies, Delirium, epidemiology, Female, Humans, Incidence, Intensive Care Units, Male, Middle Aged, Nepal, epidemiology, Prevalence, Risk Factors, Tertiary Care Centers, statistics & numerical data |
Cognitive and Brain Reserve and the Risk of Postoperative Delirium in Older Patients. | Saczynski JS, Inouye SK, Kosar C, Tommet D, Marcantonio ER, Fong T, Hshieh T, Vasunilashorn S, Metzger ED, Schmitt E, Alsop DC, Jones RN | The Lancet. Psychiatry | 2014 | |
EFFECT OF PREOPERATIVE PAIN AND DEPRESSIVE SYMPTOMS ON THE DEVELOPMENT OF POSTOPERATIVE DELIRIUM. | Kosar CM, Tabloski PA, Travison TG, Jones RN, Schmitt EM, Puelle MR, Inloes JB, Saczynski JS, Marcantonio ER, Meagher D, Reid MC, Inouye SK | The Lancet. Psychiatry | 2014 | |
Doing Damage in Delirium: The Hazards of Antipsychotic Treatment in Elderly Persons. | Inouye SK, Marcantonio ER, Metzger ED | The Lancet. Psychiatry | 2014 | |
Neurotoxicity with Antimicrobials in the Elderly: A Review. | Mattappalil A, Mergenhagen KA | Clinical therapeutics | 2014 | |
Postoperative delirium in older adults: best practice statement from the american geriatrics society. | , | Journal of the American College of Surgeons | 2015 | |
Cognitive changes after surgery in the elderly: does minimally invasive surgery influence the incidence of postoperative cognitive changes compared to open colon surgery? | Tan CB, Ng J, Jeganathan R, Kawai F, Pan CX, Pollock S, Turner J, Cohen S, Chorost M | Dementia and geriatric cognitive disorders | 2015 | |
A Prospective Comparison of Informant-based and Performance-based Dementia Screening Tools to Predict In-Hospital Delirium. | Zeng L, Josephson SA, Fukuda KA, Neuhaus J, Douglas VC | Alzheimer disease and associated disorders | 2015 | |
Multiple anticholinergic medication use and risk of hospital admission for confusion or dementia. | Kalisch Ellett LM, Pratt NL, Ramsay EN, Barratt JD, Roughead EE | Journal of the American Geriatrics Society | 2014 |
Aged, 80 and over, Anticholinergic Syndrome, diagnosis, Australia, epidemiology, Cholinergic Antagonists, administration & dosage, Cohort Studies, Confusion, chemically induced, Dementia, chemically induced, Drug Therapy, Combination, adverse effects, Female, Hospitalization, statistics & numerical data, Humans, Incidence, Male, Retrospective Studies, Risk |
The impact of frailty on postoperative delirium in cardiac surgery patients. | Jung P, Pereira MA, Hiebert B, Song X, Rockwood K, Tangri N, Arora RC | The Journal of thoracic and cardiovascular surgery | 2015 |
Age Factors, Aged, Aged, 80 and over, Aging, Cardiac Surgical Procedures, adverse effects, Chi-Square Distribution, Delirium, diagnosis, Elective Surgical Procedures, Female, Frail Elderly, Geriatric Assessment, Humans, Male, Middle Aged, Odds Ratio, Predictive Value of Tests, Prospective Studies, Questionnaires, Risk Assessment, Risk Factors, Treatment Outcome |
A meta-analysis of critically ill patients reveals several potential risk factors for delirium. | Huai J, Ye X | General hospital psychiatry | 2014 |
Critical Illness, epidemiology, Delirium, epidemiology, Humans |
A systematic review of outcomes following emergency transfer to hospital for residents of aged care facilities. | Dwyer R, Gabbe B, Stoelwinder JU, Lowthian J | Age and ageing | 2014 | |
Delirium markers in older fallers: a case-control study. | Doherty K, Archambault E, Kelly B, Rudolph JL | Clinical interventions in aging | 2014 | |
Heart rate variability in intensive care unit patients with delirium. | Zaal IJ, van der Kooi AW, van Schelven LJ, Oey PL, Slooter AJ | The Journal of neuropsychiatry and clinical neurosciences | 2015 | |
Factors associated with family caregiver dissatisfaction with acute hospital care of older cognitively impaired relatives. | Whittamore KH, Goldberg SE, Bradshaw LE, Harwood RH, | Journal of the American Geriatrics Society | 2014 | |
Risk prediction models for postoperative delirium: a systematic review and meta-analysis. | van Meenen LC, van Meenen DM, de Rooij SE, ter Riet G | Journal of the American Geriatrics Society | 2014 | |
Risk Factors for and Prediction by Caregivers of Extubation Failure in ICU Patients: A Prospective Study. | Thille AW, Boissier F, Ghezala HB, Razazi K, Mekontso-Dessap A, Brun-Buisson C | Critical care medicine | 2014 | |
Learning about the patient: an innovative interprofessional dementia and delirium education programme. | Teodorczuk A, Mukaetova-Ladinska E, Corbett S, Welfare M | The clinical teacher | 2014 | |
Novel Therapeutic Strategies for Delirium in Patients With Cancer: A Preliminary Study. | Tanimukai H, Tsujimoto H, Matsuda Y, Tokoro A, Kanemura S, Watanabe M, Tsujio I, Maeda I, Takei K, Nakajima S, Taira T, Tokuyama M, Kai T, Okamoto Y, Goya S, Kashiwagi Y | The American journal of hospice & palliative care | 2016 | |
Preoperative risk factors for postoperative delirium following hip fracture repair: a systematic review. | Oh ES, Li M, Fafowora TM, Inouye SK, Chen CH, Rosman LM, Lyketsos CG, Sieber FE, Puhan MA | International journal of geriatric psychiatry | 2015 | |
Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults. | Mehta S, Cook D, Devlin JW, Skrobik Y, Meade M, Fergusson D, Herridge M, Steinberg M, Granton J, Ferguson N, Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Mallick R, Reynolds S, Keenan S, Burry L, , | Critical care medicine | 2015 | |
Incidence and risk factors of delirium in multi-center Thai surgical intensive care units: a prospective cohort study. | Pipanmekaporn T, Chittawatanarat K, Chaiwat O, Thawitsri T, Wacharasint P, Kongsayreepong S, | Journal of intensive care | 2015 | |
Observational, longitudinal study of delirium in consecutive unselected acute medical admissions: age-specific rates and associated factors, mortality and re-admission. | Pendlebury ST, Lovett NG, Smith SC, Dutta N, Bendon C, Lloyd-Lavery A, Mehta Z, Rothwell PM | BMJ open | 2015 | |
Routine cognitive screening in older patients admitted to acute medicine: abbreviated mental test score (AMTS) and subjective memory complaint versus Montreal Cognitive Assessment and IQCODE. | Pendlebury ST, Klaus SP, Mather M, de Brito M, Wharton RM | Age and ageing | 2015 | |
Incidence and impact of delirium on clinical and functional outcomes in older patients hospitalized for acute cardiac diseases. | Noriega FJ, Vidán MT, Sánchez E, Díaz A, Serra-Rexach JA, Fernández-Avilés F, Bueno H | American heart journal | 2015 |
Acute Disease, Aged, Aged, 80 and over, Delirium, epidemiology, Female, Heart Diseases, complications, Humans, Inpatients, Male, Odds Ratio, Prevalence, Prognosis, Prospective Studies, Risk Factors, Spain, epidemiology, Survival Rate, trends |
Dexmedetomidine reduces postoperative delirium after joint replacement in elderly patients with mild cognitive impairment. | Liu Y, Ma L, Gao M, Guo W, Ma Y | Aging clinical and experimental research | 2016 | |
Factors Associated With the Development of Delirium in Elderly Patients in Intensive Care Units. | Lin WL, Chen YF, Wang J | The journal of nursing research : JNR | 2015 | |
Screening in delirium: A pilot study of two screening tools, the Simple Query for Easy Evaluation of Consciousness and Simple Question in Delirium. | Lin HS, Eeles E, Pandy S, Pinsker D, Brasch C, Yerkovich S | Australasian journal on ageing | 2015 | |
Anticholinergic Exposure During Rehabilitation: Cognitive and Physical Function Outcomes in Patients with Delirium Superimposed on Dementia. | Kolanowski A, Mogle J, Fick DM, Campbell N, Hill N, Mulhall P, Behrens L, Colancecco E, Boustani M, Clare L | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2015 | |
Nurse perceptions of the Nursing Delirium Screening Scale in two palliative care inpatient units: a focus group study. | Hosie A, Lobb E, Agar M, Davidson PM, Chye R, Phillips J | Journal of clinical nursing | 2015 | |
Postoperative Delirium in Cardiac Surgery: An Unavoidable Menace? | Hollinger A, Siegemund M, Goettel N, Steiner LA | Journal of cardiothoracic and vascular anesthesia | 2015 | |
Cerebrospinal fluid cortisol and cytokines in delirium after hip fracture. | Hall RJ, Watne LO, Robertson I, Witlox J, Kalisvaart K, Seckl JR, Juliebø V, Wyller TB, MacLullich AM | Psychoneuroendocrinology | 2015 | |
Cortisol diurnal rhythm and inflammation in delirium after hip fracture. | Hall RJ, Davis D, White TO, Robertson I, Seckl JR, MacLullich AM | Psychoneuroendocrinology | 2015 | |
Prevalence and Characteristics of Pre-Operative Delirium in Hip Fracture Patients. | Freter S, Dunbar M, Koller K, MacKnight C, Rockwood K | Gerontology | 2015 | |
Risk of Pre-and Post-Operative Delirium and the Delirium Elderly At Risk (DEAR) Tool in Hip Fracture Patients. | Freter S, Dunbar M, Koller K, MacKnight C, Rockwood K | Canadian geriatrics journal : CGJ | 2015 | |
Informal caregivers and detection of delirium in postacute care: a correlational study of the confusion assessment method (CAM), confusion assessment method-family assessment method (CAM-FAM) and DSM-IV criteria. | Flanagan NM, Spencer G | International journal of older people nursing | 2016 | |
AACN CSI Academy, part 3: Introducing the Massachusetts CSI Nursing Delirium Collaborative. | DiLibero J, Edwards E, Hanson D | Nursing management | 2015 | |
Emergency Department Delirium Screening Improves Care and Reduces Revisits for the Older Adult Patient. | Delaney M, Pepin J, Somes J | Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association | 2015 | |
Can Intraoperative Processed EEG Predict Postoperative Cognitive Dysfunction in the Elderly? | Deiner S, Luo X, Silverstein JH, Sano M | Clinical therapeutics | 2015 | |
Delirium Screening: A Systematic Review of Delirium Screening Tools in Hospitalized Patients. | De J, Wand AP | The Gerontologist | 2015 | |
Existential Absence: The Lived Experience of Family Members During Their Older Loved One's Delirium. | Day J, Higgins I | Qualitative health research | 2015 | |
Cognitive Dysfunction, Delirium, and Stroke in Cardiac Surgery Patients. | Cropsey C, Kennedy J, Han J, Pandharipande P | Seminars in cardiothoracic and vascular anesthesia | 2015 | |
Beyond Urinary Tract Infections (UTIs) and Delirium: A Systematic Review of UTIs and Neuropsychiatric Disorders. | Chae JH, Miller BJ | Journal of psychiatric practice | 2015 | |
The Association of Brain MRI Characteristics and Postoperative Delirium in Cardiac Surgery Patients. | Brown CH, Faigle R, Klinker L, Bahouth M, Max L, LaFlam A, Neufeld KJ, Mandal K, Gottesman RF, Hogue CW | Clinical therapeutics | 2015 | |
Identifying and managing patients with delirium in acute care settings. | Bond P, Goudie K | Nursing older people | 2015 |
Delirium, diagnosis, Humans, Scotland |
Nursing Education Program Improves Care for Patients With Delirium. | Becze E | ONS connect | 2015 |
Delirium, complications, Education, Nursing, organization & administration, Humans, Neoplasms, complications, Quality of Health Care |
Use of a Multimodal Implementation Strategy to Improve Delirium Screening by Nurses on an Acute Care for Elders Unit. | Afriyie-Boateng M, Loftus C, Hamelin MA | Worldviews on evidence-based nursing / Sigma Theta Tau International, Honor Society of Nursing | 2015 | |
Benzodiazepine-associated delirium in critically ill adults. | Zaal IJ, Devlin JW, Hazelbag M, Klein Klouwenberg PM, van der Kooi AW, Ong DS, Cremer OL, Groenwold RH, Slooter AJ | Intensive care medicine | 2015 | |
Dopamine Administration is a Risk Factor for Delirium in Patients Undergoing Coronary Artery Bypass Surgery. | Yilmaz S, Aksoy E, Diken AI, Yalcinkaya A, Erol ME, Cagli K | Heart, lung & circulation | 2016 | |
Different MMSE Score Is Associated with Postoperative Delirium in Young-Old and Old-Old Adults. | Wu Y, Shi Z, Wang M, Zhu Y, Li C, Li G, Marcantonio ER, Xie Z, Shen Y | PloS one | 2015 | |
Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial. | Whitlock RP, Devereaux PJ, Teoh KH, Lamy A, Vincent J, Pogue J, Paparella D, Sessler DI, Karthikeyan G, Villar JC, Zuo Y, Avezum Á, Quantz M, Tagarakis GI, Shah PJ, Abbasi SH, Zheng H, Pettit S, Chrolavicius S, Yusuf S, | Lancet (London, England) | 2015 |
Aged, Aged, 80 and over, Anti-Inflammatory Agents, therapeutic use, Cardiopulmonary Bypass, adverse effects, Double-Blind Method, Female, Humans, Male, Methylprednisolone, therapeutic use, Middle Aged, Systemic Inflammatory Response Syndrome, etiology |
Does Apolipoprotein E Genotype Increase Risk of Postoperative Delirium? | Vasunilashorn SM, Ngo L, Kosar CM, Fong TG, Jones RN, Inouye SK, Marcantonio ER | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2015 | |
New aspects of delirium in elderly patients with critical limb ischemia. | van Eijsden WA, Raats JW, Mulder PG, van der Laan L | Clinical interventions in aging | 2015 | |
Incidence of and Risk Factors for Delirium After Cardiac Surgery at a Quaternary Care Center: A Retrospective Cohort Study. | Tse L, Schwarz SK, Bowering JB, Moore RL, Barr AM | Journal of cardiothoracic and vascular anesthesia | 2015 | |
Is delirium being detected in emergency? | Traynor V, Cordato N, Burns P, Xu Y, Britten N, Duncan K, DeVries L, McKinnon C | Australasian journal on ageing | 2016 |
Age Factors, Aged, Cognition, Delirium, diagnosis, Diagnostic Errors, Emergency Services, Psychiatric, Female, Geriatric Assessment, Hospitals, Urban, Humans, Incidence, Male, Medical Audit, Medical Records, New South Wales, epidemiology, Predictive Value of Tests, Psychiatric Status Rating Scales |
Symptoms of Posttraumatic Stress after Intensive Care Delirium. | Svenningsen H, Egerod I, Christensen D, Tønnesen EK, Frydenberg M, Videbech P | BioMed research international | 2015 | |
Constipation is independently associated with delirium in critically ill ventilated patients. | Smonig R, Wallenhorst T, Bouju P, Letheulle J, Le Tulzo Y, Tadié JM, Gacouin A | Intensive care medicine | 2015 | |
Surgery plus anesthesia induces loss of attention in mice. | Ren Q, Peng M, Dong Y, Zhang Y, Chen M, Yin N, Marcantonio ER, Xie Z | Frontiers in cellular neuroscience | 2015 | |
The diurnal profile of melatonin during delirium in elderly patients--preliminary results. | Piotrowicz K, Klich-Rączka A, Pac A, Zdzienicka A, Grodzicki T | Experimental gerontology | 2015 | |
Cognitive and functional status predictors of delirium and delirium severity after coronary artery bypass graft surgery: an interim analysis of the Neuropsychiatric Outcomes After Heart Surgery study. | Oldham MA, Hawkins KA, Yuh DD, Dewar ML, Darr UM, Lysyy T, Lee HB | International psychogeriatrics / IPA | 2015 | |
Preoperative physical activity in relation to postoperative delirium in elective cardiac surgery patients. | Ogawa M, Izawa KP, Kitamura A, Ono R, Satomi-Kobayashi S, Sakai Y, Okita Y | International journal of cardiology | 2015 | |
Predicting delirium: a review of risk-stratification models. | Newman MW, O'Dwyer LC, Rosenthal L | General hospital psychiatry | 2015 | |
Long-Term Outcomes of Older Adults with and Without Delirium Immediately After Recovery from General Anesthesia for Surgery. | Neufeld KJ, Leoutsakos JM, Oh E, Sieber FE, Chandra A, Ghosh A, Schretlen DJ, Needham DM | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2015 | |
Clinical impact of delirium and antipsychotic therapy: 10-Year experience from a referral coronary care unit. | Naksuk N, Thongprayoon C, Park JY, Sharma S, Gaba P, Rosenbaum AN, Peeraphatdit T, Hu TY, Bell MR, Herasevich V, Brady PA, Kapa S, Asirvatham SJ | European heart journal. Acute cardiovascular care | 2015 | |
Hematoma Locations Predicting Delirium Symptoms After Intracerebral Hemorrhage. | Naidech AM, Polnaszek KL, Berman MD, Voss JL | Neurocritical care | 2015 | |
The effects of a tailored intensive care unit delirium prevention protocol: A randomized controlled trial. | Moon KJ, Lee SM | International journal of nursing studies | 2015 |
Cognition, Delirium, prevention & control, Humans, Intensive Care Units, Single-Blind Method |
Months backward test: A review of its use in clinical studies. | Meagher J, Leonard M, Donoghue L, O'Regan N, Timmons S, Exton C, Cullen W, Dunne C, Adamis D, Maclullich AJ, Meagher D | World journal of psychiatry | 2015 | |
An exercise program with patient's involvement and family support can modify the cognitive and affective trajectory of acutely hospitalized older medical patients: a pilot study. | Martínez-Velilla N, Garrués-Irisarri M, Ibañez-Beroiz B, Gil-Cabañas J, Richarte-García A, Idoate-Saralegui F, de Paz PC, Cambra K | Aging clinical and experimental research | 2015 | |
Comprehensive Geriatric Assessment is a useful predictive tool for postoperative delirium after gastrointestinal surgery in old-old adults. | Maekawa Y, Sugimoto K, Yamasaki M, Takeya Y, Yamamoto K, Ohishi M, Ogihara T, Shintani A, Doki Y, Mori M, Rakugi H | Geriatrics & gerontology international | 2016 | |
Acute traumatic and depressive symptoms in family members of hospitalized individuals with delirium. | Lloyd RB, Rosenthal LJ | International journal of psychiatry in medicine | 2015 | |
Influence of Ketamine on Early Postoperative Cognitive Function After Orthopedic Surgery in Elderly Patients. | Lee KH, Kim JY, Kim JW, Park JS, Lee KW, Jeon SY | Anesthesiology and pain medicine | 2015 | |
Detection of Delirium in Hospitalized Older General Medicine Patients: A Comparison of the 3D-CAM and CAM-ICU. | Kuczmarska A, Ngo LH, Guess J, O'Connor MA, Branford-White L, Palihnich K, Gallagher J, Marcantonio ER | Journal of general internal medicine | 2016 | |
Antipsychotic medications for the treatment of delirium: a systematic review and meta-analysis of randomised controlled trials. | Kishi T, Hirota T, Matsunaga S, Iwata N | Journal of neurology, neurosurgery, and psychiatry | 2015 | |
Differential Associations Between Delirium and Mortality According to Delirium Subtype and Age: A Prospective Cohort Study. | Kim SY, Kim SW, Kim JM, Shin IS, Bae KY, Shim HJ, Bae WK, Cho SH, Chung IJ, Yoon JS | Psychosomatic medicine | 2015 | |
Development of Delirium in the Intensive Care Unit in Patients after Endovascular Aortic Repair: A Retrospective Evaluation of the Prevalence and Risk Factors. | Kawatani Y, Nakamura Y, Hayashi Y, Taneichi T, Ito Y, Kurobe H, Suda Y, Hori T | Critical care research and practice | 2015 | |
Non-pharmacological interventions for sleep promotion in the intensive care unit. | Hu RF, Jiang XY, Chen J, Zeng Z, Chen XY, Li Y, Huining X, Evans DJ | The Cochrane database of systematic reviews | 2015 | |
Clinical deterioration in older adults with delirium during early hospitalisation: a prospective cohort study. | Hsieh SJ, Madahar P, Hope AA, Zapata J, Gong MN | BMJ open | 2015 | |
Human herpesvirus 6B reactivation and delirium are frequent and associated events after cord blood transplantation. | Hill JA, Boeckh M, Leisenring WM, Xie H, Adler AL, Huang ML, Fann JR, Delaney C, Zerr DM | Bone marrow transplantation | 2015 | |
Risk factors for delirium after on-pump cardiac surgery: a systematic review. | Gosselt AN, Slooter AJ, Boere PR, Zaal IJ | Critical care (London, England) | 2015 | |
Effect of Delirium and Other Major Complications on Outcomes After Elective Surgery in Older Adults. | Gleason LJ, Schmitt EM, Kosar CM, Tabloski P, Saczynski JS, Robinson T, Cooper Z, Rogers SO, Jones RN, Marcantonio ER, Inouye SK | JAMA surgery | 2015 | |
Intraoperative Electroencephalogram Suppression Predicts Postoperative Delirium. | Fritz BA, Kalarickal PL, Maybrier HR, Muench MR, Dearth D, Chen Y, Escallier KE, Ben Abdallah A, Lin N, Avidan MS | Anesthesia and analgesia | 2016 | |
Preliminary development of an ultrabrief two-item bedside test for delirium. | Fick DM, Inouye SK, Guess J, Ngo LH, Jones RN, Saczynski JS, Marcantonio ER | Journal of hospital medicine | 2015 | |
The Frequency, Characteristics, and Outcomes Among Cancer Patients With Delirium Admitted to an Acute Palliative Care Unit. | de la Cruz M, Ransing V, Yennu S, Wu J, Liu D, Reddy A, Delgado-Guay M, Bruera E | The oncologist | 2015 | |
Partial and No Recovery from Delirium in Older Hospitalized Adults: Frequency and Baseline Risk Factors. | Cole MG, Bailey R, Bonnycastle M, McCusker J, Fung S, Ciampi A, Belzile E, Bai C | Journal of the American Geriatrics Society | 2015 |
Activities of Daily Living, Aged, Aged, 80 and over, Delirium, physiopathology, Dementia, complications, Female, Follow-Up Studies, Humans, Inpatients, Intelligence Tests, Male, Prognosis, Risk Factors |
Short-Form Mini Nutritional Assessment as a useful method of predicting the development of postoperative delirium in elderly patients undergoing orthopedic surgery. | Chu CS, Liang CK, Chou MY, Lin YT, Hsu CJ, Chou PH, Chu CL | General hospital psychiatry | 2016 | |
Under-detection of delirium and impact of neurocognitive deficits on in-hospital mortality among acute geriatric and medical wards. | Bellelli G, Nobili A, Annoni G, Morandi A, Djade CD, Meagher DJ, Maclullich AM, Davis D, Mazzone A, Tettamanti M, Mannucci PM, | European journal of internal medicine | 2015 | |
Timing Is Critical in Determining the Association Between Delirium and S100 Calcium-Binding Protein B. | Beishuizen SJ, Scholtens RM, Vellekoop AE, Vrouenraets BC, Westhoff D, van de Beek D, de Rooij SE, van Munster BC | Journal of the American Geriatrics Society | 2015 | |
Delirium monitoring and patient outcomes in a general intensive care unit. | Andrews L, Silva SG, Kaplan S, Zimbro K | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2015 |
Aged, Aged, 80 and over, Delirium, diagnosis, Female, Humans, Intensive Care, methods, Intensive Care Units, Length of Stay, statistics & numerical data, Male, Neuropsychological Tests, statistics & numerical data, Nursing Assessment, methods, Outcome and Process Assessment (Health Care), statistics & numerical data, Questionnaires, Respiration, Artificial, statistics & numerical data, Retrospective Studies |
Evaluating attention in delirium: A comparison of bedside tests of attention. | Adamis D, Meagher D, Murray O, O'Neill D, O'Mahony E, Mulligan O, McCarthy G | Geriatrics & gerontology international | 2016 | |
Prevention of delirium (POD) for older people in hospital: study protocol for a randomised controlled feasibility trial. | Young J, Cheater F, Collinson M, Fletcher M, Forster A, Godfrey M, Green J, Anwar S, Hartley S, Hulme C, Inouye SK, Meads D, Santorelli G, Siddiqi N, Smith J, Teale E, Farrin AJ | Trials | 2015 | |
Intraoperative hypotension and delirium after on-pump cardiac surgery. | Wesselink EM, Kappen TH, van Klei WA, Dieleman JM, van Dijk D, Slooter AJ | British journal of anaesthesia | 2015 |
Adult, Aged, Aged, 80 and over, Antiemetics, administration & dosage, Cardiac Surgical Procedures, Cohort Studies, Delirium, epidemiology, Dexamethasone, administration & dosage, Female, Humans, Hypotension, epidemiology, Intraoperative Complications, epidemiology, Male, Middle Aged, Postoperative Complications, epidemiology, Young Adult |
Cytokines and Postoperative Delirium in Older Patients Undergoing Major Elective Surgery. | Vasunilashorn SM, Ngo L, Inouye SK, Libermann TA, Jones RN, Alsop DC, Guess J, Jastrzebski S, McElhaney JE, Kuchel GA, Marcantonio ER | The journals of gerontology. Series A, Biological sciences and medical sciences | 2015 | |
Is preoperative state anxiety a risk factor for postoperative delirium among elderly hip fracture patients? | Van Grootven B, Detroyer E, Devriendt E, Sermon A, Deschodt M, Flamaing J, Dubois C, Milisen K | Geriatrics & gerontology international | 2016 | |
Prevalence, course and factors associated with delirium in elderly patients with advanced cancer: a longitudinal observational study. | Uchida M, Okuyama T, Ito Y, Nakaguchi T, Miyazaki M, Sakamoto M, Kamiya T, Sato S, Takeyama H, Joh T, Meagher D, Akechi T | Japanese journal of clinical oncology | 2015 | |
Incidence and risk factors of postoperative delirium in elderly patients who underwent laparoscopic surgery for colorectal cancer. | Tei M, Wakasugi M, Kishi K, Tanemura M, Akamatsu H | International journal of colorectal disease | 2016 | |
Factors predicting perioperative delirium and acute exacerbation of behavioral and psychological symptoms of dementia based on admission data in elderly patients with proximal femoral fracture: A retrospective study. | Tanaka T | Geriatrics & gerontology international | 2016 |