What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Preventing Postoperative Delirium After Major Noncardiac Thoracic Surgery-A Randomized Clinical Trial.
- Authors
- Khan, B. A. Perkins, A. J. Campbell, N. L. Gao, S. Khan, S. H. Wang, S. Fuchita, M. Weber, D. J. Zarzaur, B. L. Boustani, M. A. Kesler, K.
- Year
- 2018
- Journal
- J Am Geriatr Soc
- Abstract
OBJECTIVES: To assess the efficacy of haloperidol in reducing postoperative delirium in individuals undergoing thoracic surgery. DESIGN: Randomized double-blind placebo-controlled trial. SETTING: Surgical intensive care unit (ICU) of tertiary care center. PARTICIPANTS: Individuals undergoing thoracic surgery (N=135). INTERVENTION: Low-dose intravenous haloperidol (0.5 mg three times daily for a total of 11 doses) administered postoperatively. MEASUREMENTS: The primary outcome was delirium incidence during hospitalization. Secondary outcomes were time to delirium, delirium duration, delirium severity, and ICU and hospital length of stay. Delirium was assessed using the Confusion Assessment Method for the ICU and delirium severity using the Delirium Rating Scale-Revised. RESULTS: Sixty-eight participants were randomized to receive haloperidol and 67 placebo. No significant differences were observed between those receiving haloperidol and those receiving placebo in incident delirium (n=15 (22.1%) vs n=19 (28.4%); p = .43), time to delirium (p = .43), delirium duration (median 1 day, interquartile range (IQR) 1-2 days vs median 1 day, IQR 1-2 days; p = .71), delirium severity, ICU length of stay (median 2.2 days, IQR 1-3.3 days vs median 2.3 days, IQR 1-4 days; p = .29), or hospital length of stay (median 10 days, IQR 8-11.5 days vs median 10 days, IQR 8-12 days; p = .41). In the esophagectomy subgroup (n = 84), the haloperidol group was less likely to experience incident delirium (n=10 (23.8%) vs n=17 (40.5%); p = .16). There were no differences in time to delirium (p = .14), delirium duration (median 1 day, IQR 1-2 days vs median 1 day, IQR 1-2 days; p = .71), delirium severity, or hospital length of stay (median 11 days, IQR 10-12 days vs median days 11, IQR 10-15 days; p = .26). ICU length of stay was significantly shorter in the haloperidol group (median 2.8 days, IQR 1.1-3.8 days vs median 3.1 days, IQR 2.1-5.1 days; p = .03). Safety events were comparable between the groups. CONCLUSION: Low-dose postoperative haloperidol did not reduce delirium in individuals undergoing thoracic surgery but may be efficacious in those undergoing esophagectomy. J Am Geriatr Soc 66:2289-2297, 2018.
- PMID
- Keywords
Icu
cognition
delirium
esophagectomy
haloperidol
- Page(s)
- 2289-97
- Volume
- 66
- Issue
- 12
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| The epidemiology of delirium: challenges and opportunities for population studies. | Davis DH, Kreisel SH, Muniz Terrera G, Hall AJ, Morandi A, Boustani M, Neufeld KJ, Lee HB, Maclullich AM, Brayne C | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2013 |
Cognition Disorders, epidemiology, Data Collection, methods, Delirium, diagnosis, Disease Progression, Humans, Research Design |
| Delirium during acute illness in nursing home residents. | Boockvar K, Signor D, Ramaswamy R, Hung W | Journal of the American Medical Directors Association | 2013 |
Acute Disease, Aged, Cognition Disorders, epidemiology, Delirium, epidemiology, Female, Geriatric Assessment, Humans, Incidence, Male, New York City, epidemiology, Nursing Homes, Prospective Studies, Risk Factors |
| Antipsychotic prescribing patterns, and the factors and outcomes associated with their use, among patients requiring prolonged mechanical ventilation in the long-term acute care hospital setting. | Al-Qadheeb NS, O'Connor HH, White AC, Neidhardt A, Albizati M, Joseph B, Roberts RJ, Ruthazer RR, Devlin JW | The Annals of pharmacotherapy | 2013 |
Adult, Aged, Aged, 80 and over, Antipsychotic Agents, administration & dosage, Benzodiazepines, administration & dosage, Caregivers, Cohort Studies, Delirium, diagnosis, Dibenzothiazepines, administration & dosage, Drug Administration Schedule, Female, Hospitals, Chronic Disease, Humans, Male, Massachusetts, Medical Records, Middle Aged, Patient Participation, Physician’s Practice Patterns, Psychiatric Status Rating Scales, Respiration, Artificial, psychology, Retrospective Studies |
| Pre-existing cerebral infarcts as a risk factor for delirium after coronary artery bypass graft surgery. | Otomo S, Maekawa K, Goto T, Baba T, Yoshitake A | Interactive cardiovascular and thoracic surgery | 2013 |
Aortic Diseases, complications, Atherosclerosis, complications, Cerebral Angiography, Cerebral Infarction, complications, Cognition, Cognition Disorders, complications, Coronary Artery Bypass, adverse effects, Delirium, diagnosis, Female, Humans, Magnetic Resonance Angiography, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Risk Factors, Surgical Procedures, Elective, Ultrasonography, Interventional |
| Delirium after cardiac surgery: incidence and risk factors. | Smulter N, Lingehall HC, Gustafson Y, Olofsson B, Engström KG | Interactive cardiovascular and thoracic surgery | 2013 |
Age Factors, Aged, Aged, 80 and over, Cardiac Surgical Procedures, adverse effects, Delirium, diagnosis, Female, Humans, Incidence, Logistic Models, Male, Multivariate Analysis, Odds Ratio, Psychiatric Status Rating Scales, Risk Factors, Sweden, epidemiology |
| Predictive factors for agitation severity of hyperactive delirium in terminally ill cancer patients in a general hospital using ordered logistic regression analysis. | Kanbayashi Y, Hatano Y, Hata Y, Morita T, Fukui K, Hosokawa T | Journal of palliative medicine | 2013 |
Aged, Anti-Bacterial Agents, therapeutic use, Anti-Inflammatory Agents, Non-Steroidal, therapeutic use, Bilirubin, analysis, Delirium, epidemiology, Female, Hematologic Neoplasms, complications, Hospitals, General, Humans, Japan, epidemiology, Logistic Models, Male, Middle Aged, Predictive Value of Tests, Prevalence, Psychomotor Agitation, epidemiology, Risk Factors, Severity of Illness Index, Sex Factors, Terminally Ill |
| Outcomes of a Geriatric Liaison Intervention to Prevent the Development of Postoperative Delirium in Frail Elderly Cancer Patients: Report on a Multicentre, Randomized, Controlled Trial. | Hempenius L, Slaets JP, van Asselt D, de Bock GH, Wiggers T, van Leeuwen BL | PloS one | 2013 | |
| Care in specialist medical and mental health unit compared with standard care for older people with cognitive impairment admitted to general hospital: randomised controlled trial (NIHR TEAM trial). | Goldberg SE, Bradshaw LE, Kearney FC, Russell C, Whittamore KH, Foster PE, Mamza J, Gladman JR, Jones RG, Lewis SA, Porock D, Harwood RH, | BMJ (Clinical research ed.) | 2013 |
Aged, Aged, 80 and over, Cognition Disorders, therapy, Delirium, therapy, Dementia, therapy, Female, Great Britain, Hospitalization, Hospitals, General, Humans, Length of Stay, Male, Neuropsychological Tests, Outcome Assessment (Health Care), Patient Readmission, Psychiatric Department, Hospital, Quality of Health Care, Quality of Life |
| At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response. | Cunningham C, Maclullich AM | Brain, behavior, and immunity | 2013 |
Adaptation, Physiological, physiology, Animals, Anxiety, complications, Brain, physiopathology, Cognition, physiology, Delirium, etiology, Depression, complications, Humans, Illness Behavior, physiology, Inflammation, complications, Neurodegenerative Diseases, complications, Stress, Physiological, physiology |
| The stress response to surgery and postoperative delirium: evidence of hypothalamic-pituitary-adrenal axis hyperresponsiveness and decreased suppression of the GH/IGF-1 Axis. | Cerejeira J, Batista P, Nogueira V, Vaz-Serra A, Mukaetova-Ladinska EB | Journal of geriatric psychiatry and neurology | 2013 |
Aged, Aged, 80 and over, Anesthesia, Arthroplasty, Replacement, Hip, adverse effects, Cognition, physiology, Data Interpretation, Statistical, Delirium, etiology, Female, Growth Hormone, blood, Humans, Hydrocortisone, blood, Hypothalamo-Hypophyseal System, physiopathology, Immune System, physiology, Inflammation Mediators, blood, Insulin-Like Growth Factor I, physiology, Male, Middle Aged, Neurosecretory Systems, physiology, Perioperative Care, Pituitary-Adrenal System, physiopathology, Postoperative Complications, etiology, Postoperative Period, Stress, Physiological, physiology |
| Do earplugs and eye masks affect sleep and delirium outcomes in the critically ill? | Alway A, Halm MA, Shilhanek M, St Pierre J | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2013 |
Critical Illness, Delirium, prevention & control, Ear Protective Devices, Humans, Intensive Care Units, Masks, Self Report, Sleep Disorders, prevention & control |
| Outcomes of early delirium diagnosis after general anesthesia in the elderly. | Neufeld KJ, Leoutsakos JM, Sieber FE, Wanamaker BL, Gibson Chambers JJ, Rao V, Schretlen DJ, Needham DM | Anesthesia and analgesia | 2013 |
Activities of Daily Living, Aftercare, Age Factors, Aged, Aged, 80 and over, Anesthesia Recovery Period, Anesthesia, General, adverse effects, Baltimore, epidemiology, Cognition, Cognition Disorders, diagnosis, Delirium, diagnosis, Early Diagnosis, Female, Humans, Institutionalization, Linear Models, Logistic Models, Male, Multivariate Analysis, Neuropsychological Tests, Patient Discharge, Patient Transfer, Predictive Value of Tests, Prevalence, Prognosis, Prospective Studies, Psychiatric Status Rating Scales, Recovery Room, Risk Factors, Time Factors |
| An enhanced exercise and cognitive programme does not appear to reduce incident delirium in hospitalised patients: a randomised controlled trial. | Jeffs KJ, Berlowitz DJ, Grant S, Lawlor V, Graco M, de Morton NA, Savige JA, Lim WK | BMJ open | 2013 | |
| BIS-guided anesthesia decreases postoperative delirium and cognitive decline. | Chan MT, Cheng BC, Lee TM, Gin T, | Journal of neurosurgical anesthesiology | 2013 |
Aged, Anesthesia, General, adverse effects, Asian Continental Ancestry Group, Cognition Disorders, etiology, Color Perception, physiology, Consciousness Monitors, Delirium, etiology, Female, Humans, Male, Neuropsychological Tests, Postoperative Complications, prevention & control, Prospective Studies, Risk Factors, Treatment Outcome, Verbal Behavior, Verbal Learning |
| Investigating polypharmacy and drug burden index in hospitalised older people. | Best O, Gnjidic D, Hilmer SN, Naganathan V, McLachlan AJ | Internal medicine journal | 2013 |
Age Factors, Aged, Aged, 80 and over, Cholinergic Antagonists, administration & dosage, Cohort Studies, Delirium, chemically induced, Female, Hospitalization, trends, Humans, Hypnotics and Sedatives, administration & dosage, Male, New South Wales, epidemiology, Polypharmacy, Retrospective Studies |
| An analytical framework for delirium research in palliative care settings: integrated epidemiologic, clinician-researcher, and knowledge user perspectives. | Lawlor PG, Davis DH, Ansari M, Hosie A, Kanji S, Momoli F, Bush SH, Watanabe S, Currow DC, Gagnon B, Agar M, Bruera E, Meagher DJ, de Rooij SE, Adamis D, Caraceni A, Marchington K, Stewart DJ | Journal of pain and symptom management | 2014 | |
| Practical assessment of delirium in palliative care. | Leonard MM, Nekolaichuk C, Meagher DJ, Barnes C, Gaudreau JD, Watanabe S, Agar M, Bush SH, Lawlor PG | Journal of pain and symptom management | 2014 | |
| Delirium diagnostic and classification challenges in palliative care: subsyndromal delirium, comorbid delirium-dementia, and psychomotor subtypes. | Leonard MM, Agar M, Spiller JA, Davis B, Mohamad MM, Meagher DJ, Lawlor PG | Journal of pain and symptom management | 2014 | |
| End-of-life delirium: issues regarding recognition, optimal management, and the role of sedation in the dying phase. | Bush SH, Leonard MM, Agar M, Spiller JA, Hosie A, Wright DK, Meagher DJ, Currow DC, Bruera E, Lawlor PG | Journal of pain and symptom management | 2014 | |
| A comparison of the revised Delirium Rating Scale (DRS-R98) and the Memorial Delirium Assessment Scale (MDAS) in a palliative care cohort with DSM-IV delirium. | O'Sullivan R, Meagher D, Leonard M, Watne LO, Hall RJ, Maclullich AM, Trzepacz P, Adamis D | Palliative & supportive care | 2015 | |
| The descriptive epidemiology of delirium symptoms in a large population-based cohort study: results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). | Davis DH, Barnes LE, Stephan BC, MacLullich AM, Meagher D, Copeland J, Matthews FE, Brayne C, | BMC geriatrics | 2014 | |
| Phenomenological and biological correlates of improved cognitive function in hospitalized elderly medical inpatients. | Adamis D, Meagher D, Treloar A, Dunne C, Larvin M, Martin FC, Macdonald AJ | Archives of gerontology and geriatrics | 2014 | |
| Delirium during psychiatric admission increases mortality in psychiatric patients during and after hospitalization. A nationwide study from 1995 through 2012. | Lundberg AS, Gustafsson LN, Meagher D, Munk-Jørgensen P | Journal of psychosomatic research | 2014 | |
| The CareWell in Hospital program to improve the quality of care for frail elderly inpatients: results of a before-after study with focus on surgical patients. | Bakker FC, Persoon A, Bredie SJ, van Haren-Willems J, Leferink VJ, Noyez L, Schoon Y, Olde Rikkert MG | American journal of surgery | 2014 | |
| Outcomes of an innovative model of acute delirium care: the Geriatric Monitoring Unit (GMU). | Chong MS, Chan M, Tay L, Ding YY | Clinical interventions in aging | 2014 | |
| Delirium in elderly people--authors'reply. | Inouye SK, Westendorp RG, Saczynski JS, Kimchi EY, Cleinman AA | Lancet | 2014 |
Delirium, diagnosis, Humans |
| Delirium risk prediction, healthcare use and mortality of elderly adults in the emergency department. | Kennedy M, Enander RA, Tadiri SP, Wolfe RE, Shapiro NI, Marcantonio ER | Journal of the American Geriatrics Society | 2014 |
Aged, Aged, 80 and over, Delirium, complications, Delivery of Health Care, utilization, Emergency Service, Hospital, Female, Follow-Up Studies, Geriatric Assessment, methods, Humans, Incidence, Length of Stay, trends, Male, Massachusetts, epidemiology, Mental Status Schedule, Prospective Studies, Risk Factors, Stroke, complications, Survival Rate, trends |
| Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium. | Xie Z, Swain CA, Ward SA, Zheng H, Dong Y, Sunder N, Burke DW, Escobar D, Zhang Y, Marcantonio ER | Annals of clinical and translational neurology | 2014 | |
| Calibration and validation of an innovative approach for estimating general cognitive performance. | Gross AL, Jones RN, Fong TG, Tommet D, Inouye SK | Neuroepidemiology | 2014 | |
| The modified Hospital Elder Life Program: adapting a complex intervention for feasibility and scalability in a surgical setting. | Chen CC, Saczynski J, Inouye SK | Journal of gerontological nursing | 2014 |
Aged, Evidence-Based Practice, Feasibility Studies, Health Services for the Aged, organization & administration, Hospitals, Humans, Surgical Procedures, Operative |
| NICE to HELP: operationalizing National Institute for Health and Clinical Excellence guidelines to improve clinical practice. | Yue J, Tabloski P, Dowal SL, Puelle MR, Nandan R, Inouye SK | Journal of the American Geriatrics Society | 2014 |
Aged, 80 and over, Delirium, diagnosis, Delivery of Health Care, standards, Geriatrics, standards, Great Britain, epidemiology, Humans, Practice Guidelines as Topic, Prevalence |
| Delirium diagnosis methodology used in research: a survey-based study. | Neufeld KJ, Nelliot A, Inouye SK, Ely EW, Bienvenu OJ, Lee HB, Needham DM | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2014 | |
| Systemic inflammation impairs attention and cognitive flexibility but not associative learning in aged rats: possible implications for delirium. | Culley DJ, Snayd M, Baxter MG, Xie Z, Lee IH, Rudolph J, Inouye SK, Marcantonio ER, Crosby G | Frontiers in aging neuroscience | 2014 | |
| The Prevention of Delirium and Complications Associated with Surgical Treatments (PODCAST) study: protocol for an international multicentre randomised controlled trial. | Avidan MS, Fritz BA, Maybrier HR, Muench MR, Escallier KE, Chen Y, Ben Abdallah A, Veselis RA, Hudetz JA, Pagel PS, Noh G, Pryor K, Kaiser H, Arya VK, Pong R, Jacobsohn E, Grocott HP, Choi S, Downey RJ, Inouye SK, Mashour GA | BMJ open | 2014 | |
| Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle. | Balas MC, Vasilevskis EE, Olsen KM, Schmid KK, Shostrom V, Cohen MZ, Peitz G, Gannon DE, Sisson J, Sullivan J, Stothert JC, Lazure J, Nuss SL, Jawa RS, Freihaut F, Ely EW, Burke WJ | Critical care medicine | 2014 |
Adult, Aged, Clinical Protocols, Cohort Studies, Delirium, therapy, Exercise, Female, Humans, Hypnotics and Sedatives, therapeutic use, Immobilization, adverse effects, Intensive Care, methods, Male, Middle Aged, Prospective Studies, Regression Analysis, Respiration, Artificial, adverse effects, Treatment Outcome, Ventilator Weaning, methods |
| Comparison of symptoms of delirium across various motoric subtypes. | Grover S, Sharma A, Aggarwal M, Mattoo SK, Chakrabarti S, Malhotra S, Avasthi A, Kulhara P, Basu D | Psychiatry and clinical neurosciences | 2014 | |
| The efficacy of peri-operative interventions to decrease postoperative delirium in non-cardiac surgery: a systematic review and meta-analysis. | Moyce Z, Rodseth RN, Biccard BM | Anaesthesia | 2014 |
Delirium, prevention & control, Humans, Perioperative Care, methods, Postoperative Complications, prevention & control, Referral and Consultation |
| Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients. | Alexander SA, Ren D, Gunn SR, Kochanek PM, Tate J, Ikonomovic M, Conley YP | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2014 | |
| Decreasing inappropriate unable-to-assess ratings for the confusion assessment method for the intensive care unit. | Swan JT | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2014 | |
| Anticholinergic activity in cerebrospinal fluid and serum in individuals with hip fracture with and without delirium. | Watne LO, Hall RJ, Molden E, Raeder J, Frihagen F, MacLullich AM, Juliebø V, Nyman A, Meagher D, Wyller TB | Journal of the American Geriatrics Society | 2014 |
APACHE, Activities of Daily Living, Aged, Aged, 80 and over, Cholinergic Antagonists, blood, Comorbidity, Delirium, diagnosis, Female, Hip Fractures, complications, Humans, Male, Middle Aged, Norway, Prospective Studies, Questionnaires, Scotland, Severity of Illness Index |
| Antipsychotics for delirium in the general hospital setting in consecutive 2453 inpatients: a prospective observational study. | Hatta K, Kishi Y, Wada K, Odawara T, Takeuchi T, Shiganami T, Tsuchida K, Oshima Y, Uchimura N, Akaho R, Watanabe A, Taira T, Nishimura K, Hashimoto N, Usui C, Nakamura H | International journal of geriatric psychiatry | 2014 | |
| The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts. | Inouye SK, Kosar CM, Tommet D, Schmitt EM, Puelle MR, Saczynski JS, Marcantonio ER, Jones RN | Annals of internal medicine | 2014 |
Activities of Daily Living, Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Delirium, diagnosis, Female, Hospital Costs, Humans, Length of Stay, Male, Nursing Homes, Psychological Tests, Psychometrics, Severity of Illness Index |
| A tale of two methods: chart and interview methods for identifying delirium. | Saczynski JS, Kosar CM, Xu G, Puelle MR, Schmitt E, Jones RN, Marcantonio ER, Wong B, Isaza I, Inouye SK | Journal of the American Geriatrics Society | 2014 |
Aged, Aged, 80 and over, Cohort Studies, Delirium, diagnosis, Female, Humans, Interview, Psychological, methods, Male, Medical Records, Prospective Studies, Psychological Tests, Reproducibility of Results, Severity of Illness Index |
| Effect of leaflet-based intervention on family members of terminally ill patients with cancer having delirium: historical control study. | Otani H, Morita T, Uno S, Yamamoto R, Hirose H, Matsubara T, Takigawa C, Sasaki K | The American journal of hospice & palliative care | 2014 | |
| Preparation to care for confused older patients in general hospitals: a study of UK health professionals. | Griffiths A, Knight A, Harwood R, Gladman JR | Age and ageing | 2014 | |
| Prediction of delirium in critically ill patients with elevated C-reactive protein. | Zhang Z, Pan L, Deng H, Ni H, Xu X | Journal of critical care | 2014 | |
| Barriers and facilitators to implementing delirium rounds in a clinical trial across three diverse hospital settings. | Yevchak AM, Fick DM, McDowell J, Monroe T, May K, Grove L, Kolanowski AM, Waller JL, Inouye SK | Clinical nursing research | 2014 | |
| Feasibility and acceptability of a delirium prevention program for cognitively impaired long term care residents: a participatory approach. | Voyer P, McCusker J, Cole MG, Monette J, Champoux N, Vu M, Ciampi A, Sanche S, Richard S, de Raad M | Journal of the American Medical Directors Association | 2014 | |
| Safety incidents involving confused and forgetful older patients in a specialised care setting - analysis of the safety incidents reported to the HaiPro reporting system. | Kinnunen-Luovi K, Saarnio R, Isola A | Journal of clinical nursing | 2014 | |
| Prognosis of delirium in hospitalized elderly: worse than we thought. | Dasgupta M, Brymer C | International journal of geriatric psychiatry | 2014 | |
| Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. | Brummel NE, Jackson JC, Pandharipande PP, Thompson JL, Shintani AK, Dittus RS, Gill TM, Bernard GR, Ely EW, Girard TD | Critical care medicine | 2014 |
Activities of Daily Living, Aged, Delirium, complications, Female, Humans, Intensive Care Units, Male, Middle Aged, Prospective Studies, Questionnaires, Respiration, Artificial, Survivors, Time Factors |
| Validation and psychometric properties of the Delirium Motor Subtype Scale in elderly hip fracture patients (Dutch version). | Slor CJ, Adamis D, Jansen RW, Meagher DJ, Witlox J, Houdijk AP, de Jonghe JF | Archives of gerontology and geriatrics | 2014 |
Aged, Aged, 80 and over, Delirium, classification, Female, Fracture Fixation, Hip Fractures, complications, Humans, Male, Motor Activity, Netherlands, Psychiatric Status Rating Scales, ROC Curve, Reproducibility of Results, Severity of Illness Index |
| Delirium is a predictor of in-hospital mortality in elderly patients with community acquired pneumonia. | Pieralli F, Vannucchi V, Mancini A, Grazzini M, Paolacci G, Morettini A, Nozzoli C | Internal and emergency medicine | 2014 | |
| Delirium in elderly people. | Inouye SK, Westendorp RG, Saczynski JS | Lancet | 2014 |
Aged, Biomedical Research, methods, Cognition Disorders, etiology, Delirium, diagnosis, Dementia, etiology, Humans, Prognosis, Risk Factors |
| Delirium in adult patients receiving palliative care: a systematic review of the literature. | Sánchez-Román S, Beltrán Zavala C, Lara Solares A, Chiquete E | Revista de psiquiatrí́a y salud mental | 2014 | |
| Is delirium an unrecognized threat to patient safety in Korean intensive care units? | Moon KJ, Piao J, Jin Y, Lee SM | Journal of nursing care quality | 2014 | |
| The impact of soluble interleukin-2 receptor as a biomarker of delirium. | Baranyi A, Rothenhäusler HB | Psychosomatics | 2014 | |
| Pharmacologic risk factors for post-operative delirium in total joint arthroplasty patients: a case-control study. | Nandi S, Harvey WF, Saillant J, Kazakin A, Talmo C, Bono J | The Journal of arthroplasty | 2014 |
Aged, Analgesics, Opioid, adverse effects, Anesthetics, adverse effects, Arthroplasty, Replacement, Hip, adverse effects, Arthroplasty, Replacement, Knee, adverse effects, Benzodiazepines, adverse effects, Case-Control Studies, Cognition Disorders, Delirium, chemically induced, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors |
| Effects of a modified Hospital Elder Life Program on frailty in individuals undergoing major elective abdominal surgery. | Chen CC, Chen CN, Lai IR, Huang GH, Saczynski JS, Inouye SK | Journal of the American Geriatrics Society | 2014 |
Abdomen, surgery, Activities of Daily Living, Aged, Female, Frail Elderly, psychology, Geriatric Assessment, methods, Hospitalization, statistics & numerical data, Humans, Male, Odds Ratio, Postoperative Care, methods, Postoperative Complications, prevention & control, Surgical Procedures, Elective, Taiwan |
| First Spanish version of the Memorial Delirium Assessment Scale: psychometric properties, responsiveness, and factor loadings. | Noguera A, Carvajal A, Alonso-Babarro A, Chisholm G, Bruera E, Centeno C | Journal of pain and symptom management | 2014 | |
| Detection of delirium in palliative care unit patients: a prospective descriptive study of the Delirium Observation Screening Scale administered by bedside nurses. | Detroyer E, Clement PM, Baeten N, Pennemans M, Decruyenaere M, Vandenberghe J, Menten J, Joosten E, Milisen K | Palliative medicine | 2014 | |
| Intensive care delirium - effect on memories and health-related quality of life - a follow-up study. | Svenningsen H, Tønnesen EK, Videbech P, Frydenberg M, Christensen D, Egerod I | Journal of clinical nursing | 2014 | |
| Corticosteroids and transition to delirium in patients with acute lung injury. | Schreiber MP, Colantuoni E, Bienvenu OJ, Neufeld KJ, Chen KF, Shanholtz C, Mendez-Tellez PA, Needham DM | Critical care medicine | 2014 |
APACHE, Acute Lung Injury, complications, Adrenal Cortex Hormones, administration & dosage, Adult, Age Factors, Critical Illness, therapy, Delirium, diagnosis, Female, Humans, Intensive Care Units, Male, Markov Chains, Middle Aged, Organ Dysfunction Scores, Prospective Studies, Respiration, Artificial, Risk Factors, Severity of Illness Index, Treatment Outcome |
| Interprofessional education for delirium care: a systematic review. | Sockalingam S, Tan A, Hawa R, Pollex H, Abbey S, Hodges BD | Journal of interprofessional care | 2014 | |
| Delirium, a Symptom of UTI in the Elderly: Fact or Fable? A Systematic Review. | Balogun SA, Philbrick JT | Canadian geriatrics journal : CGJ | 2014 | |
| Improved analgesia, sedation, and delirium protocol associated with decreased duration of delirium and mechanical ventilation. | Dale CR, Kannas DA, Fan VS, Daniel SL, Deem S, Yanez ND, Hough CL, Dellit TH, Treggiari MM | Annals of the American Thoracic Society | 2014 | |
| Race and documentation of cognitive impairment in hospitalized older adults. | Campbell NL, Cantor BB, Hui SL, Perkins A, Khan BA, Farber MO, Nazir A, Garrett SL, Ely EW, Boustani MA | Journal of the American Geriatrics Society | 2014 |
Aged, Cognition, Cognition Disorders, diagnosis, Continental Population Groups, Female, Geriatric Assessment, methods, Health Records, Personal, Humans, Indiana, epidemiology, Inpatients, statistics & numerical data, Male, Mental Status Schedule, Prevalence, Questionnaires, Retrospective Studies, Risk Factors, Urban Population |
| Delirium in the cardiac surgical ICU. | Brown CH | Current opinion in anaesthesiology | 2014 | |
| Postoperative delirium in Parkinson's disease patients following deep brain stimulation surgery. | Carlson JD, Neumiller JJ, Swain LD, Mark J, McLeod P, Hirschauer J | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | 2014 | |
| Prospective observational study of dementia in older patients admitted to acute hospitals. | Travers C, Byrne GJ, Pachana NA, Klein K, Gray LC | Australasian journal on ageing | 2014 | |
| Do patients of delirium have catatonic features? An exploratory study. | Grover S, Ghosh A, Ghormode D | Psychiatry and clinical neurosciences | 2014 | |
| Frequency and factors associated with falls in patients with advanced cancer presenting to an outpatient supportive care clinic. | Kuriya M, Yennurajalingam S, de la Cruz MG, Wei W, Palla S, Bruera E | Palliative & supportive care | 2015 | |
| Impact of anticholinergic discontinuation on cognitive outcomes in older people: a systematic review. | Salahudeen MS, Duffull SB, Nishtala PS | Drugs & aging | 2014 | |
| Patient frailty: the elephant in the operating room. | Hubbard RE, Story DA | Anaesthesia | 2014 |
Aged, Aged, 80 and over, Frail Elderly, statistics & numerical data, Geriatric Assessment, methods, Humans, Inpatients, statistics & numerical data, Risk Assessment, Risk Factors, Surgical Procedures, Operative |
| Should general anaesthesia be avoided in the elderly? | Strøm C, Rasmussen LS, Sieber FE | Anaesthesia | 2014 |
Aged, Aged, 80 and over, Anesthesia, General, adverse effects, Cognition Disorders, chemically induced, Delirium, chemically induced, Geriatric Assessment, methods, Humans, Postoperative Complications, chemically induced, Risk Factors |
| Cognitive interviews guide design of a new CAM patient expectations questionnaire. | Sherman KJ, Eaves ER, Ritenbaugh C, Hsu C, Cherkin DC, Turner JA | BMC complementary and alternative medicine | 2014 | |
| The association between C-reactive protein and delirium in 710 acute elderly hospital admissions. | Ritchie CW, Newman TH, Leurent B, Sampson EL | International psychogeriatrics / IPA | 2014 |
Acute Disease, Aged, Biological Markers, analysis, C-Reactive Protein, analysis, Cardiovascular Diseases, complications, Confusion, diagnosis, Delirium, blood, Female, Geriatric Assessment, methods, Hospitalization, statistics & numerical data, Humans, Infection, complications, London, Male, Musculoskeletal Diseases, complications, Neurologic Examination, methods, Prospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Statistics as Topic |
| The impact of acute brain dysfunction in the outcomes of mechanically ventilated cancer patients. | Almeida IC, Soares M, Bozza FA, Shinotsuka CR, Bujokas R, Souza-Dantas VC, Ely EW, Salluh JI | PloS one | 2014 | |
| Sedation and delirium in the intensive care unit. | Reade MC, Finfer S | The New England journal of medicine | 2014 |
Algorithms, Analgesics, adverse effects, Delirium, drug therapy, Humans, Hypnotics and Sedatives, administration & dosage, Intensive Care Units, Pain, complications, Postoperative Care, adverse effects, Postoperative Complications, drug therapy, Respiration, Artificial |
| New consciousness scale for delirium. | Neerland BE, Ahmed M, Watne LO, Hov KR, Wyller TB | Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række | 2014 |
Confusion, classification, Consciousness, classification, Delirium, classification, Humans, Norway, Observation, Severity of Illness Index, Translations |
| Missing link or not, mobilise against delirium. | Page VJ, Casarin A | Critical care (London, England) | 2014 | |
| Postoperative delirium in a substudy of cardiothoracic surgical patients in the BAG-RECALL clinical trial. | Whitlock EL, Torres BA, Lin N, Helsten DL, Nadelson MR, Mashour GA, Avidan MS | Anesthesia and analgesia | 2014 |
Aged, Anesthesia, General, Anesthetics, pharmacokinetics, Bayes Theorem, Cardiac Surgical Procedures, adverse effects, Confidence Intervals, Confusion, chemically induced, Consciousness Monitors, Delirium, etiology, Female, Humans, Intraoperative Period, Length of Stay, Logistic Models, Male, Middle Aged, Neuropsychological Tests, Postoperative Complications, psychology, Predictive Value of Tests, Thoracic Surgical Procedures, adverse effects, Treatment Outcome |
| Statin use and risk of delirium in the critically ill. | Page VJ, Davis D, Zhao XB, Norton S, Casarin A, Brown T, Ely EW, McAuley DF | American journal of respiratory and critical care medicine | 2014 |
Adult, Aged, Aged, 80 and over, Biological Markers, blood, C-Reactive Protein, metabolism, Critical Care, methods, Delirium, blood, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, therapeutic use, Intensive Care Units, Linear Models, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Outcome Assessment (Health Care), Propensity Score, Prospective Studies, Risk Factors |
| A relational ethical approach to end-of-life delirium. | Wright DK, Brajtman S, Macdonald ME | Journal of pain and symptom management | 2014 | |
| Rapidly reversible, sedation-related delirium versus persistent delirium in the intensive care unit. | Patel SB, Poston JT, Pohlman A, Hall JB, Kress JP | American journal of respiratory and critical care medicine | 2014 |
Adolescent, Adult, Aged, Aged, 80 and over, Conscious Sedation, adverse effects, Delirium, chemically induced, Female, Fentanyl, adverse effects, Follow-Up Studies, Humans, Hypnotics and Sedatives, adverse effects, Intensive Care, methods, Intensive Care Units, Length of Stay, statistics & numerical data, Logistic Models, Male, Middle Aged, Outcome Assessment (Health Care), Prognosis, Propofol, adverse effects, Proportional Hazards Models, Prospective Studies, Respiration, Artificial, statistics & numerical data, Single-Blind Method, Young Adult |
| Management of pain, agitation, and delirium in critically ill patients. | Pandharipande PP, Patel MB, Barr J | Polskie Archiwum Medycyny Wewnętrznej | 2014 | |
| Care and Respect for Elders in Emergencies program: a preliminary report of a volunteer approach to enhance care in the emergency department. | Sanon M, Baumlin KM, Kaplan SS, Grudzen CR | Journal of the American Geriatrics Society | 2014 |
Activities of Daily Living, Aged, Emergencies, Emergency Service, Hospital, standards, Female, Humans, Male, Patient Care Team, standards, Program Development, methods, Quality Improvement, Quality of Life, Retrospective Studies, Volunteers |
| Concordance between DSM-IV and DSM-5 criteria for delirium diagnosis in a pooled database of 768 prospectively evaluated patients using the delirium rating scale-revised-98. | Meagher DJ, Morandi A, Inouye SK, Ely W, Adamis D, Maclullich AJ, Rudolph JL, Neufeld K, Leonard M, Bellelli G, Davis D, Teodorczuk A, Kriesel S, Thomas C, Hasemann W, Timmons S, O Regan N, Grover S, Jabbar F, Cullen W, Dunne C, Kamholz B, Van Munster BC, | BMC medicine | 2014 | |
| Perioperative cognitive trajectory in adults. | Nadelson MR, Sanders RD, Avidan MS | British journal of anaesthesia | 2014 |
Affect, Cognition, physiology, Cognition Disorders, epidemiology, Critical Illness, Delirium, epidemiology, Dementia, epidemiology, Humans, Inflammation, psychology, Pain, Postoperative, epidemiology, Perioperative Period, psychology, Postoperative Complications, genetics, Quality of Life, Research |
| Underrepresentation of patients with pre-existing cognitive impairment in pharmaceutical trials on prophylactic or therapeutic treatments for delirium: a systematic review. | de Jonghe A, van de Glind EM, van Munster BC, de Rooij SE | Journal of psychosomatic research | 2014 | |
| Haloperidol prophylaxis does not prevent postoperative delirium in elderly patients: a randomized, open-label prospective trial. | Fukata S, Kawabata Y, Fujisiro K, Katagawa Y, Kuroiwa K, Akiyama H, Terabe Y, Ando M, Kawamura T, Hattori H | Surgery today | 2014 | |
| Transcranial Doppler to measure cerebral blood flow in delirium superimposed on dementia. A cohort study. | Caplan GA, Lan Z, Newton L, Kvelde T, McVeigh C, Hill MA | Journal of the American Medical Directors Association | 2014 | |
| Increasing anticholinergic burden and delirium in palliative care inpatients. | Zimmerman KM, Salow M, Skarf LM, Kostas T, Paquin A, Simone MJ, Rudolph J | Palliative medicine | 2014 | |
| Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial. | Hatta K, Kishi Y, Wada K, Takeuchi T, Odawara T, Usui C, Nakamura H, | JAMA psychiatry | 2014 |
Aged, Aged, 80 and over, Alzheimer Disease, diagnosis, Delirium, diagnosis, Female, Hospitals, General, Hospitals, University, Humans, Indenes, adverse effects, Kaplan-Meier Estimate, Male, Risk, Single-Blind Method |
| Delirium, agitation, and symptom distress within the final seven days of life among cancer patients receiving hospice care. | de la Cruz M, Noguera A, San Miguel-Arregui MT, Williams J, Chisholm G, Bruera E | Palliative & supportive care | 2015 |
Aged, Aged, 80 and over, Delirium, epidemiology, Female, Home Nursing, Hospice Care, Humans, Male, Middle Aged, Neoplasms, nursing, Predictive Value of Tests, Psychomotor Agitation, epidemiology, Retrospective Studies, Sensitivity and Specificity, Severity of Illness Index, Stress, Psychological, epidemiology, Surveys and Questionnaires, Terminal Care |
| Randomized ICU trials do not demonstrate an association between interventions that reduce delirium duration and short-term mortality: a systematic review and meta-analysis. | Al-Qadheeb NS, Balk EM, Fraser GL, Skrobik Y, Riker RR, Kress JP, Whitehead S, Devlin JW | Critical care medicine | 2014 |
Delirium, mortality, Intensive Care Units, Time Factors |
| Delirium detection based on monitoring of blinks and eye movements. | van der Kooi AW, Rots ML, Huiskamp G, Klijn FA, Koek HL, Kluin J, Leijten FS, Slooter AJ | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2014 | |
| Do patient characteristics influence nursing adherence to a guideline for preventing delirium? | Ijkema R, Langelaan M, van de Steeg L, Wagner C | Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing / Sigma Theta Tau | 2014 |
Aged, Aged, 80 and over, Delirium, nursing, Female, Guideline Adherence, statistics & numerical data, Humans, Male, Mass Screening, nursing, Medical Records, Nursing Evaluation Research, Patients, statistics & numerical data, Practice Guidelines as Topic, Retrospective Studies, Risk Assessment |
| Burden in caregivers of cognitively impaired elderly adults at time of hospitalization: a cross-sectional analysis. | Shankar KN, Hirschman KB, Hanlon AL, Naylor MD | Journal of the American Geriatrics Society | 2014 |
Activities of Daily Living, Adaptation, Psychological, Adolescent, Adult, Aged, Aged, 80 and over, Burnout, Professional, epidemiology, Caregivers, psychology, Cognition Disorders, nursing, Cross-Sectional Studies, Female, Humans, Incidence, Male, Middle Aged, United States, epidemiology, Young Adult |
| Recalibration of the delirium prediction model for ICU patients (PRE-DELIRIC): a multinational observational study. | van den Boogaard M, Schoonhoven L, Maseda E, Plowright C, Jones C, Luetz A, Sackey PV, Jorens PG, Aitken LM, van Haren FM, Donders R, van der Hoeven JG, Pickkers P | Intensive care medicine | 2014 |