What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Delirium is a Potential Predictor of Unfavorable Long-term Functional Outcomes in Patients with Acute Ischemic Stroke: A Prospective Observational Study
- Authors
- Lin, C. Zhang, H. Xiao, F. Tu, Y. Lin, Y. Zhan, L. Lin, Y. Li, Y. Xie, C. Chen, Y.
- Year
- 2025
- Journal
- J Inflamm Res
- Abstract
PURPOSE: Delirium is an acute fluctuating impairment of attention and awareness, common in acute ischemic stroke (AIS). This study aimed to evaluate the prognostic significance of delirium for neurological function at 3 months post-stroke, and develop a predictive model integrating delirium and biomarkers to enhance prognostic accuracy. METHODS: We conducted a prospective cohort study of patients admitted to the stroke unit (n=722). All patients were screened for daily delirium during clinical care. Plasma biomarkers were measured within 24 hours after admission. The main outcomes were evaluated with the 3-months modified Rankin Scale (mRS). RESULTS: Delirium developed in 10.2% of patients during the acute phase of stroke. Patients with post-stroke delirium (PSD) was significantly older (median age 74 vs 68 years, P<0.001), more likely to have pre-stroke cognitive impairment (14.9% vs 4.8%, P=0.001), a higher prevalence of cardiovascular history (35.1% vs 16.2%, P<0.001). PSD was also associated with higher scores of NIHSS (14.3 vs 9.1, P<0.001) and greater scores of mRS (3.0 vs 1.5, P<0.001) at admission. PSD patients showed worse outcomes, with elevated NIHSS and mRS scores at discharge and 3-month follow-up, as well as higher mortality rates (5.4% vs 1.4%, P=0.025). Biomarker analysis revealed increased plasma levels of inflammatory (white blood cells, neutrophils, C-reactive protein) and coagulation biomarkers (fibrinogen, D-dimer) in PSD patients, particularly those with poorer outcomes (P<0.01). Our model, which incorporated delirium and biomarkers of inflammation and coagulation dysfunction, demonstrated strong predictive accuracy for adverse outcomes at 3 months with an AUC of 0.779 (95% CI=0.736-0.822), with clinical utility confirmed by decision curve analysis. CONCLUSION: PSD is a strong independent predictor of poor 3-month outcomes in AIS, including higher mortality and disability. Our findings highlight the critical role of inflammation and coagulation dysfunction in the pathogenesis of PSD. Furthermore, we present the clinical utility of a predictive model integrating delirium and relevant biomarkers to assess the risk of adverse outcomes at 3 months, suggesting potential targets for intervention.
- PMID
PMID: 40125080
PMCID: PMC11929518
- Keywords
Ais Psd acute ischemic stroke biomarkers coagulation dysfunction delirium mRS modified rankin scale neuroinflammation post-stroke delirium
- Page(s)
- Volume
- Issue
Title | Authors | Journal | Year | Keywords |
---|---|---|---|---|
Impact of Cognitive Impairment Across Specialties: Summary of a Report From the U13 Conference Series | Carpenter, C. R. McFarland, F. Avidan, M. Berger, M. Inouye, S. K. Karlawish, J. Lin, F. R. Marcantonio, E. Morris, J. C. Reuben, D. B. Shah, R. C. Whitson, H. E. Asthana, S. Verghese, J. | J Am Geriatr Soc | 2019 |
Aging |
Pharmacological interventions for the treatment of delirium in critically ill adults | Burry, L. Hutton, B. Williamson, D. R. Mehta, S. Adhikari, N. K. Cheng, W. Ely, E. W. Egerod, I. Fergusson, D. A. Rose, L. | Cochrane Database Syst Rev | 2019 | |
Unrecognized Incident Delirium in Older Emergency Department Patients | Boucher, V. Lamontagne, M. E. Nadeau, A. Carmichael, P. H. Yadav, K. Voyer, P. Pelletier, M. Gouin, E. Daoust, R. Berthelot, S. Morin, M. Lemire, S. Minh Vu, T. T. Lee, J. Emond, M. | J Emerg Med | 2019 |
delirium |
Delirium in the intensive care setting dependent on the Richmond Agitation and Sedation Scale (RASS): Inattention and visuo-spatial impairment as potential screening domains | Boettger, S. Meyer, R. Richter, A. Rudiger, A. Schubert, M. Jenewein, J. Nunez, D. G. | Palliat Support Care | 2019 |
Drs-r-98 |
Analgesic and psychoactive medications and the risk of falls in relation to delirium in single-bed rooms compared to multiple-bed rooms in geriatric inpatients | Blandfort, S. Gregersen, M. Rahbek, K. Juul, S. Damsgaard, E. M. | Aging Clin Exp Res | 2019 |
Analgesic |
"They take a lot of pressure off us": Volunteers reducing staff and family care burden and contributing to quality of care for older patients with cognitive impairment in rural hospitals | Blair, A. Bateman, C. Anderson, K. | Australas J Ageing | 2019 |
delirium |
Portal Hypertension Is Associated With Congestive Encephalopathy and Delirium After Cardiac Surgery | Benkreira, A. Beaubien-Souligny, W. Mailhot, T. Bouabdallaoui, N. Robillard, P. Desjardins, G. Lamarche, Y. Cossette, S. Denault, A. | Can J Cardiol | 2019 | |
Occurrence and Practices for Pain, Agitation, and Delirium in Intensive Care Unit Patients | Arroyo-Novoa, C. M. Figueroa-Ramos, M. I. Puntillo, K. A. | P R Health Sci J | 2019 |
Agitation |
Arabic intensive care delirium screening checklist's validity and reliability: A multicenter study | Al-Qadheeb, N. S. Nazer, L. H. Aisa, T. M. Osman, H. O. Rugaan, A. S. Alzahrani, A. S. Ghonimat, I. M. Mohammed, A. M. Maghrabi, K. Alrowaished, A. A. Hussein, N. H. Maslamani, Y. A. Falatah, S. Skrobik, Y. | J Crit Care | 2019 |
Arabic |
The association of preoperative delirium with postoperative outcomes following hip surgery in the elderly | Agrawal, S. Turk, R. Burton, B. N. Ingrande, J. Gabriel, R. A. | J Clin Anesth | 2019 |
Acs nsqip |
Factors associated with falling in elderly hospital patients. | Salgado R, Lord SR, Packer J, Ehrlich F | Gerontology | 1994 |
Accidental Falls, Aged, Aged, 80 and over, Case-Control Studies, Cerebrovascular Disorders, complications, Cognition Disorders, complications, Female, Hospitalization, Humans, Male, Postural Balance, Psychotropic Drugs, therapeutic use, Retrospective Studies, Risk Factors |
Delirium and physical restraint in the hospitalized elderly. | Sullivan-Marx EM | Image--the journal of nursing scholarship | 1994 |
Aged, Cognition Disorders, psychology, Delirium, nursing, Female, Hospitalization, Humans, Inpatients, psychology, Male, Nursing Assessment, Psychomotor Agitation, Restraint, Physical, Risk Factors |
Increasing the recognition of delirium in elderly patients. | Rockwood K, Cosway S, Stolee P, Kydd D, Carver D, Jarrett P, O'Brien B | Journal of the American Geriatrics Society | 1994 |
Aged, Cognition, Confusion, Delirium, diagnosis, Educational Status, Female, Humans, Inpatients, Male, Medical Staff, Hospital, Psychiatric Status Rating Scales |
The relationship of postoperative delirium with psychoactive medications. | Marcantonio ER, Juarez G, Goldman L, Mangione CM, Ludwig LE, Lind L, Katz N, Cook EF, Orav EJ, Lee TH | JAMA | 1994 |
Aged, Analgesia, Epidural, Analgesia, Patient-Controlled, Benzodiazepines, administration & dosage, Case-Control Studies, Cholinergic Antagonists, administration & dosage, Delirium, diagnosis, Humans, Logistic Models, Matched-Pair Analysis, Mental Status Schedule, Middle Aged, Narcotics, administration & dosage, Postoperative Period, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors |
Detection of psychiatric disorders in elderly medical inpatients. | Bowler C, Boyle A, Branford M, Cooper SA, Harper R, Lindesay J | Age and ageing | 1994 |
Aged, Aged, 80 and over, Delirium, diagnosis, Delirium, Dementia, Amnestic, Cognitive Disorders, diagnosis, Dementia, diagnosis, Female, Geriatrics, Hospital Units, Humans, Inpatients, Male, Mental Disorders, diagnosis, Middle Aged, Nursing Assessment |
Predictors of formal home health care use in elderly patients after hospitalization. | Solomon DH, Wagner DR, Marenberg ME, Acampora D, Cooney LM, Inouye SK | Journal of the American Geriatrics Society | 1993 |
Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Comorbidity, Confidence Intervals, Educational Status, Female, Forecasting, Geriatric Assessment, Health Planning, Health Services Research, Home Care Services, statistics & numerical data, Hospitalization, Humans, Male, Patient Discharge, Patient Readmission, Proportional Hazards Models, Prospective Studies, Risk Factors, Severity of Illness Index, Social Support |
Cognitive performance in a high-functioning community-dwelling elderly population. | Inouye SK, Albert MS, Mohs R, Sun K, Berkman LF | Journal of gerontology | 1993 |
Aged, psychology, Cognition, Female, Humans, Male, Memory, Socioeconomic Factors |
Hazards of hospitalization of the elderly. | Creditor MC | Annals of internal medicine | 1993 |
Accidental Falls, Activities of Daily Living, Aged, Aging, physiology, Bed Rest, adverse effects, Frail Elderly, Hospitalization, Humans, Iatrogenic Disease, Nursing Homes, Risk Factors |
Acute confusion in the elderly. | Foreman MD | Annual review of nursing research | 1993 |
Acute Disease, Age Factors, Aged, Confusion, diagnosis, Forecasting, Geriatric Assessment, Geriatric Nursing, methods, Humans, Incidence, Mental Status Schedule, Nursing Assessment, Nursing Research, trends, Prevalence, Prognosis, Risk Factors, Terminology as Topic |
Adverse events in the hospitalized elderly. | Foreman MD, Theis SL, Anderson MA | Clinical nursing research | 1993 |
Age Factors, Aged, Confusion, epidemiology, Drug Hypersensitivity, epidemiology, Female, Hospitalization, Humans, Incidence, Male, Pressure Ulcer, epidemiology |
Delirium in hospitalized elderly patients: recognition, evaluation, and management. | Inouye SK | Connecticut medicine | 1993 |
Aged, Delirium, diagnosis, Diagnosis, Differential, Geriatric Assessment, Hospitalization, Humans, Neurologic Examination |
A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics. | Inouye SK, Viscoli CM, Horwitz RI, Hurst LD, Tinetti ME | Annals of internal medicine | 1993 |
Aged, Aged, 80 and over, Cognition Disorders, complications, Decision Support Techniques, Dehydration, complications, Delirium, complications, Female, Hospitalization, Humans, Male, Patient Admission, Prospective Studies, Risk Factors, Severity of Illness Index, Vision Disorders, complications |
A predictive index for functional decline in hospitalized elderly medical patients. | Inouye SK, Wagner DR, Acampora D, Horwitz RI, Cooney LM, Hurst LD, Tinetti ME | Journal of general internal medicine | 1993 |
Activities of Daily Living, Aged, Aged, 80 and over, Chi-Square Distribution, Cohort Studies, Connecticut, Female, Geriatric Assessment, Hospital Bed Capacity, 500 and over, Hospitals, University, utilization, Humans, Likelihood Functions, Male, Multivariate Analysis, Prevalence, Proportional Hazards Models, Prospective Studies, Reproducibility of Results, Risk Factors, Single-Blind Method |
A prospective study of delirium in elderly patients admitted to a psychiatric hospital. | Koponen HJ, Riekkinen PJ | Psychological medicine | 1993 |
Aged, Brain, physiopathology, Brain Diseases, complications, Delirium, diagnosis, Female, Follow-Up Studies, Hospitalization, Humans, Male, Patient Admission, Patient Discharge, Prospective Studies, Psychiatric Status Rating Scales |
Challenge for the 90s: a safe and cost-effective sitter program. | Lipkis-Orlando R, Mian P, Levy G, Lussier-Cushing M | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | 1993 |
Cost-Benefit Analysis, Humans, Job Description, Mental Disorders, nursing, Nurses’ Aides, Psychiatric Nursing, economics |
Delirium in hospitalized elderly patients. | Pompei P | Hospital practice (Office ed.) | 1993 |
Aged, Aged, 80 and over, Blood Glucose, Cognition, Delirium, complications, Female, Glucose, therapeutic use, Hospitalization, Humans, Lung Diseases, Obstructive, complications, Mental Status Schedule, Prognosis |
Acute delirium and functional decline in the hospitalized elderly patient. | Murray AM, Levkoff SE, Wetle TT, Beckett L, Cleary PD, Schor JD, Lipsitz LA, Rowe JW, Evans DA | Journal of gerontology | 1993 |
Activities of Daily Living, Acute Disease, Aged, Boston, Delirium, physiopathology, Female, Geriatric Assessment, Hospitalization, Hospitals, Teaching, Humans, Linear Models, Male, Nursing Homes, Prospective Studies, Risk Factors |
A controlled trial of a nursing-centered intervention in hospitalized elderly medical patients: the Yale Geriatric Care Program. | Inouye SK, Wagner DR, Acampora D, Horwitz RI, Cooney LM, Tinetii ME | Journal of the American Geriatrics Society | 1993 |
Activities of Daily Living, Aged, Aged, 80 and over, Connecticut, Female, Geriatric Assessment, Geriatric Nursing, organization & administration, Hospital Bed Capacity, 500 and over, Hospitals, University, organization & administration, Humans, Intervention Studies, Male, Models, Nursing, Nursing Service, Hospital, organization & administration, Outcome Assessment (Health Care), Patient Care Team, Prospective Studies |
Hospital Outcomes Project for the Elderly (HOPE): rationale and design for a prospective pooled analysis. | Margitić SE, Inouye SK, Thomas JL, Cassel CK, Regenstreif DI, Kowal J | Journal of the American Geriatrics Society | 1993 |
Activities of Daily Living, Aged, Aged, 80 and over, Female, Health Services Research, methods, Hospitalization, Humans, Male, Outcome Assessment (Health Care), Prospective Studies, United States |
The Yale Geriatric Care Program: a model of care to prevent functional decline in hospitalized elderly patients. | Inouye SK, Acampora D, Miller RL, Fulmer T, Hurst LD, Cooney LM | Journal of the American Geriatrics Society | 1993 |
Activities of Daily Living, Aged, Connecticut, Education, Nursing, Continuing, Geriatric Assessment, Geriatric Nursing, methods, Hospitals, University, organization & administration, Humans, Intervention Studies, Models, Nursing, Nursing Service, Hospital, organization & administration, Outcome and Process Assessment (Health Care), Patient Care Team, Prospective Studies |
Interrupted care. The effects of paging on pediatric resident activities. | Blum NJ, Lieu TA | American journal of diseases of children (1960) | 1992 |
Burnout, Professional, epidemiology, Evaluation Studies as Topic, Hospital Communication Systems, statistics & numerical data, Hospitals, Pediatric, Hospitals, University, Humans, Internship and Residency, statistics & numerical data, Medical Staff, Hospital, psychology, Pediatrics, standards, Philadelphia, epidemiology, Prospective Studies, Quality of Health Care, Risk Factors |
Delirium in older patients. | Francis J | Journal of the American Geriatrics Society | 1992 |
Aged, Clinical Protocols, Delirium, diagnosis, Diagnosis, Differential, Drug-Related Side Effects and Adverse Reactions, Forecasting, Geriatrics, methods, Humans, Incidence, Prevalence, Prognosis, Risk Factors |
Diagnostic dilemma: cognitive impairment in the elderly. | Foreman MD, Grabowski R | Journal of gerontological nursing | 1992 |
Aged, Cognition Disorders, classification, Diagnosis, Differential, Humans, Mental Status Schedule |
Delirium in newly admitted elderly patients: a prospective study. | Jitapunkul S, Pillay I, Ebrahim S | The Quarterly journal of medicine | 1992 |
Acute Disease, psychology, Aged, Aged, 80 and over, Delirium, epidemiology, Female, Humans, Intelligence Tests, Length of Stay, London, Long-Term Care, Male, Middle Aged, Patient Admission, statistics & numerical data, Prevalence, Prospective Studies |
Confusion in the elderly hospitalized patient. | McBride S | The Canadian nurse | 1992 |
Aged, Confusion, nursing, Geriatric Nursing, methods, Hospitalization, Humans, Patient Education as Topic |
Delirium. The occurrence and persistence of symptoms among elderly hospitalized patients. | Levkoff SE, Evans DA, Liptzin B, Cleary PD, Lipsitz LA, Wetle TT, Reilly CH, Pilgrim DM, Schor J, Rowe J | Archives of internal medicine | 1992 |
Aged, Aged, 80 and over, Cognition, Delirium, diagnosis, Female, Hospitalization, Humans, Length of Stay, Male, Prospective Studies, Risk Factors |
Dealing with delirium. A common problem in hospitalized elderly patients. | O'Brien ME | Postgraduate medicine | 1992 |
Aged, Delirium, diagnosis, Dementia, diagnosis, Diagnosis, Differential, Geriatrics, Hospitalization, Humans |
Delirium in the medically ill elderly: operationalizing the DSM-III criteria. | Gottlieb GL, Johnson J, Wanich C, Sullivan E | International psychogeriatrics / IPA | 1991 |
Aged, Delirium, diagnosis, Female, Hospitalization, Humans, Male, Neuropsychological Tests, statistics & numerical data, Patient Care Team, Pennsylvania, epidemiology, Psychiatric Status Rating Scales, statistics & numerical data, Psychometrics |
Epidemiology of delirium: an overview of research issues and findings. | Levkoff S, Cleary P, Liptzin B, Evans DA | International psychogeriatrics / IPA | 1991 |
Aged, Cross-Sectional Studies, Delirium, diagnosis, Humans, Incidence, Neuropsychological Tests, Psychiatric Status Rating Scales, United States, epidemiology |
An empirical study of diagnostic criteria for delirium. | Liptzin B, Levkoff SE, Cleary PD, Pilgrim DM, Reilly CH, Albert M, Wetle TT | The American journal of psychiatry | 1991 |
Aged, Aged, 80 and over, Delirium, classification, Humans, Inpatients, psychology, Length of Stay, statistics & numerical data, Psychiatric Status Rating Scales, Psychometrics, Research Design, Terminology as Topic |
Cognitive impairment and hospital use. | Weiler PG, Lubben JE, Chi I | American journal of public health | 1991 |
Activities of Daily Living, Aged, Aged, 80 and over, Cognition Disorders, etiology, Cohort Studies, Dementia, complications, Female, Hospitalization, statistics & numerical data, Humans, Intelligence Tests, Length of Stay, statistics & numerical data, Male, Odds Ratio, Random Allocation |
Advancing age and the syndrome of delirium: ancient conundrums and modern research advances. | Miller NE, Lipowski ZJ | International psychogeriatrics / IPA | 1991 |
Aged, Arousal, physiology, Brain, physiopathology, Delirium, etiology, Electroencephalography, Humans, Length of Stay, Neuropsychological Tests, Neurotransmitter Agents, physiology |
Delirium/acute confusional states: evaluation devices in nursing. | Williams MA | International psychogeriatrics / IPA | 1991 |
Aged, Aged, 80 and over, Cerebral Cortex, physiopathology, Confusion, diagnosis, Delirium, diagnosis, Hospitalization, Humans, Neuropsychological Tests, statistics & numerical data, Nursing Assessment, Nursing Diagnosis, Psychometrics |
Cognitive impairment and length of hospital stay in older persons. | Binder EF, Robins LN | Journal of the American Geriatrics Society | 1990 |
Age Factors, Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Educational Status, Female, Hospitalization, statistics & numerical data, Humans, Interview, Psychological, Length of Stay, Male, Mental Status Schedule, standards, Predictive Value of Tests, Psychiatric Status Rating Scales, standards, Questionnaires, Risk Factors |
A prospective study of delirium in hospitalized elderly. | Francis J, Martin D, Kapoor WN | JAMA | 1990 |
Activities of Daily Living, Aged, Delirium, epidemiology, Follow-Up Studies, Hospital Bed Capacity, 500 and over, Hospitalization, statistics & numerical data, Humans, Interviews as Topic, Length of Stay, statistics & numerical data, Logistic Models, Mental Status Schedule, Pennsylvania, epidemiology, Risk Factors |
Effect of psychiatric liaison nurse specialist consultation on the care of medical-surgical patients with sitters. | Talley S, Davis DS, Goicoechea N, Brown L, Barber LL | Archives of psychiatric nursing | 1990 |
Adult, Aged, Aged, 80 and over, Consultants, Female, Hospitals, General, Humans, Male, Mental Disorders, nursing, Middle Aged, Nurse Clinicians, Nurses’ Aides, utilization, Nursing Evaluation Research, Psychiatric Nursing |
Clarifying confusion: the confusion assessment method. A new method for detection of delirium. | Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI | Annals of internal medicine | 1990 |
Aged, Aged, 80 and over, Algorithms, Confusion, diagnosis, Delirium, diagnosis, Female, Humans, Male, Prospective Studies, Psychiatric Status Rating Scales, Questionnaires, Reproducibility of Results, Sensitivity and Specificity |
Histological studies on the effects of pineal 5-methoxyindoles on the reproductive organs of the male golden hamster. | Ooi VE, Ng TB | Journal of pineal research | 1989 |
5-Methoxytryptamine, pharmacology, Animals, Cricetinae, Hydroxyindoleacetic Acid, analogs & derivatives, Indoles, pharmacology, Leydig Cells, drug effects, Male, Melatonin, pharmacology, Mesocricetus, Pineal Gland, physiology, Seminal Vesicles, anatomy & histology, Testis, anatomy & histology |
Cryptococcal pyarthrosis complicating gouty arthritis. | Sinnott JT, Holt DA | Southern medical journal | 1989 |
Acute Disease, Arthritis, Gouty, complications, Arthritis, Infectious, complications, Cryptococcosis, complications, Cryptococcus neoformans, isolation & purification, Drug Therapy, Combination, Female, Humans, Kidney Transplantation, Knee Joint, Metacarpophalangeal Joint, Middle Aged |
Confusion in the hospitalized elderly: incidence, onset, and associated factors. | Foreman MD | Research in nursing & health | 1989 |
Adaptation, Psychological, Aged, psychology, Cognition Disorders, etiology, Confusion, etiology, Female, Holistic Health, Hospitalization, Humans, Male, Risk Factors |
Duration of delirium shortened by the correction of electrolyte imbalance. | Koizumi J, Shiraishi H, Ofuku K, Suzuki T | The Japanese journal of psychiatry and neurology | 1988 |
Adult, Aged, Aged, 80 and over, Delirium, blood, Electrolytes, administration & dosage, Female, Humans, Male, Middle Aged, Water-Electrolyte Imbalance, blood |
Identification of factors associated with the diagnosis of delirium in elderly hospitalized patients. | Levkoff SE, Safran C, Cleary PD, Gallop J, Phillips RS | Journal of the American Geriatrics Society | 1988 |
Aged, Aged, 80 and over, Delirium, diagnosis, Female, Humans, Length of Stay, Leukocyte Count, Male, Probability, Proteinuria, complications, Risk Factors, Serum Albumin, deficiency, Urinary Tract Infections, complications |
A prospective study of delirium and prolonged hospital stay. Exploratory study. | Thomas RI, Cameron DJ, Fahs MC | Archives of general psychiatry | 1988 |
Aged, Delirium, diagnosis, Diagnosis-Related Groups, Disease, complications, Economics, Hospital, Female, Follow-Up Studies, Humans, Length of Stay, economics, Male, Middle Aged, Prospective Studies |
Delirium: a test of the Diagnostic and Statistical Manual III criteria on medical inpatients. | Cameron DJ, Thomas RI, Mulvihill M, Bronheim H | Journal of the American Geriatrics Society | 1987 |
Adult, Aged, Cross-Sectional Studies, Delirium, classification, Diagnostic Tests, Routine, Hospitalization, Humans, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales |
Acute confusional states in hospitalized elderly: a research dilemma. | Foreman MD | Nursing research | 1986 |
Acute Disease, Aged, Cognition Disorders, classification, Confusion, classification, Hospitalization, Humans, Models, Biological, Research |
After the fall--confusion. | Campbell EB, Williams MA, Mlynarczyk SM | The American journal of nursing | 1986 |
Aged, Cognition Disorders, etiology, Confusion, etiology, Fear, Hallucinations, nursing, Hip Fractures, nursing, Hospitalization, Humans, Illusions, nursing, Immobilization, Nursing Assessment |
Bedside cognitive screening instruments. A critical assessment. | Nelson A, Fogel BS, Faust D | The Journal of nervous and mental disease | 1986 |
Adult, Aged, Cognition Disorders, diagnosis, Diagnosis, Differential, False Negative Reactions, False Positive Reactions, Female, Hospitalization, Humans, Male, Mental Disorders, complications, Middle Aged, Psychiatric Status Rating Scales, Psychometrics, Research Design |
Acute confusional states (delirium) in the hospitalized elderly. | Levkoff SE, Besdine RW, Wetle T | Annual review of gerontology & geriatrics | 1986 |
Aged, Cognition Disorders, etiology, Confusion, etiology, Delirium, etiology, Hospitalization, Humans, Postoperative Complications, etiology |
Confusion after admission to hospital in elderly patients using benzodiazepines. | Foy A, Drinkwater V, March S, Mearrick P | British medical journal (Clinical research ed.) | 1986 |
Aged, Aged, 80 and over, Anti-Anxiety Agents, adverse effects, Benzodiazepines, Cognition Disorders, chemically induced, Confusion, chemically induced, Hospitalization, Humans, Prospective Studies, Substance Withdrawal Syndrome |
Effect of fasting on hypoxia tolerance of mice in relation to oxygen consumption and heart rate. | Watanabe C, Suzuki T | Aviation, space, and environmental medicine | 1985 |
Animals, Anoxia, physiopathology, Body Weight, Energy Metabolism, Fasting, Heart Rate, Male, Mice, Mice, Inbred ICR, Oxygen, blood |
Acute confusional states in the elderly: an algorithm. | Foreman MD | Dimensions of critical care nursing : DCCN | 1984 |
Aged, Cognition Disorders, Confusion, Geriatric Nursing, Humans, Nursing Assessment, Nursing Process, Patient Care Planning |
Transient cognitive disorders (delirium, acute confusional states) in the elderly. | Lipowski ZJ | The American journal of psychiatry | 1983 |
Acute Disease, Aged, Cognition Disorders, diagnosis, Confusion, diagnosis, Delirium, diagnosis, Dementia, diagnosis, Diagnosis, Differential, Humans, Stress, Psychological, psychology |
Adverse consequences of hospitalization in the elderly. | Gillick MR, Serrell NA, Gillick LS | Social science & medicine (1982) | 1982 |
Aged, psychology, Boston, Confusion, psychology, Eating Disorders, psychology, Hospital Bed Capacity, 500 and over, Hospitalization, Humans, Iatrogenic Disease, epidemiology, Prospective Studies, Psychophysiologic Disorders, Social Adjustment, Urinary Incontinence, psychology |
How to prevent confusion in hospitalized elderly. | Remakus BL, Shelly RM | Geriatrics | 1981 |
Aged, Cognition Disorders, prevention & control, Confusion, prevention & control, Female, Hospitalization, Humans, Male |
The relationship of 'nuclear' and 'atypical' psychoses: some proposals for a classification of disorders in the borderlands of schizophrenia. | Roth M, McClelland H | Psychiatria clinica | 1979 |
Adult, Brain Diseases, diagnosis, Delirium, Dementia, Amnestic, Cognitive Disorders, diagnosis, Diagnosis, Differential, Humans, Male, Prognosis, Psychoses, Substance-Induced, diagnosis, Psychotic Disorders, classification, Schizophrenia, diagnosis, Schizophrenic Psychology, Substance-Related Disorders, diagnosis, Suicide, Attempted, psychology, Time Factors |
A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. | Pfeiffer E | Journal of the American Geriatrics Society | 1975 |
Aged, Continental Population Groups, Delirium, Dementia, Amnestic, Cognitive Disorders, diagnosis, Educational Status, Humans, Intelligence Tests, Mental Disorders, diagnosis, Psychiatric Status Rating Scales, Psychometrics |
The cause of delirium in patients with hip fracture. | Brauer C, Morrison RS, Silberzweig SB, Siu AL | Archives of internal medicine | 2000 |
Aged, Aged, 80 and over, Confounding Factors (Epidemiology), Delirium, chemically induced, Female, Hip Fractures, complications, Humans, Male, Mental Status Schedule, New York City, epidemiology, Prevalence, Prospective Studies, Risk Factors |
Large neutral amino acid changes and delirium in febrile elderly medical patients. | Flacker JM, Lipsitz LA | The journals of gerontology. Series A, Biological sciences and medical sciences | 2000 |
Aged, Aged, 80 and over, Amino Acids, blood, Chromatography, High Pressure Liquid, Delirium, blood, Female, Fever, blood, Frail Elderly, Humans, Linear Models, Male, Phenylalanine, blood, Prospective Studies, Tryptophan, blood |
The role of the advanced practice nurse in facilitating a clinical research study. Screening for delirium. | Lacko LA, Dellasega C, Salerno FA, Singer H, DeLucca J, Rothenberger C | Clinical nurse specialist CNS | 2000 |
Aged, Aged, 80 and over, Clinical Nursing Research, Delirium, diagnosis, Education, Nursing, Continuing, Female, Geriatric Assessment, Geriatric Nursing, methods, Hospitals, Community, Humans, Male, Mass Screening, nursing, Nurse Clinicians, Nursing Staff, Hospital, Staff Development |
A comparison of pain and its treatment in advanced dementia and cognitively intact patients with hip fracture. | Morrison RS, Siu AL | Journal of pain and symptom management | 2000 |
Aged, Aged, 80 and over, Cognition Disorders, complications, Cohort Studies, Dementia, complications, Female, Hip Fractures, complications, Humans, Male, Pain, complications |
Prevalence and detection of delirium in elderly emergency department patients. | Elie M, Rousseau F, Cole M, Primeau F, McCusker J, Bellavance F | CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne | 2000 |
Age Factors, Aged, Aged, 80 and over, Confidence Intervals, Confusion, diagnosis, Delirium, diagnosis, Demography, Emergency Service, Hospital, statistics & numerical data, Female, Hospitals, Teaching, Humans, Lung Diseases, diagnosis, Male, Medical Records, Mental Status Schedule, Nervous System Diseases, diagnosis, Prevalence, Quebec, epidemiology, Sensitivity and Specificity, Severity of Illness Index, Single-Blind Method |
The bedside confusion scale: development of a portable bedside test for confusion and its application to the palliative medicine population. | Stillman MJ, Rybicki LA | Journal of palliative medicine | 2000 | |
Development and validation of a brief observer-rated screening scale for depression in elderly medical patients. | Hammond MF, O'Keeffe ST, Barer DH | Age and ageing | 2000 |
Aged, Aged, 80 and over, Depression, diagnosis, Female, Geriatric Assessment, Health Services for the Aged, Humans, Male, Predictive Value of Tests, Psychiatric Status Rating Scales, standards, Sensitivity and Specificity |
Predisposing and precipitating factors for delirium in hospitalized older patients. | Inouye SK | Dementia and geriatric cognitive disorders | 1999 |
Aged, Causality, Cohort Studies, Delirium, epidemiology, Disease Susceptibility, Hospitalization, statistics & numerical data, Humans, Models, Neurological, Prospective Studies |
Goal-setting in clinical medicine. | Bradley EH, Bogardus ST, Tinetti ME, Inouye SK | Social science & medicine (1982) | 1999 |
Aged, Aged, 80 and over, Communication, Dementia, Female, Geriatric Assessment, Goals, Humans, Male, Physician-Patient Relations, Professional-Family Relations, Risk-Taking, Social Values |
Epidemiology of delirium. | Bucht G, Gustafson Y, Sandberg O | Dementia and geriatric cognitive disorders | 1999 |
Aged, Aged, 80 and over, Delirium, epidemiology, Health Services for the Aged, statistics & numerical data, Hospitals, General, statistics & numerical data, Humans, Incidence, Postoperative Complications, Prevalence, World Health |
Delirium in an acute geriatric unit: clinical aspects. | Feldman J, Yaretzky A, Kaizimov N, Alterman P, Vigder C | Archives of gerontology and geriatrics | 1999 | |
A multicomponent intervention to prevent delirium in hospitalized older patients. | Inouye SK, Bogardus ST, Charpentier PA, Leo-Summers L, Acampora D, Holford TR, Cooney LM | The New England journal of medicine | 1999 |
Aged, psychology, Aged, 80 and over, psychology, Clinical Protocols, Delirium, classification, Female, Hospitalization, Humans, Incidence, Logistic Models, Male, Prospective Studies, Risk Factors, Treatment Outcome |
Delirium: a symptom of how hospital care is failing older persons and a window to improve quality of hospital care. | Inouye SK, Schlesinger MJ, Lydon TJ | The American journal of medicine | 1999 |
Aged, Attitude of Health Personnel, Clinical Competence, Delirium, diagnosis, Diagnosis, Differential, Education, Medical, Hospitalization, Humans, Iatrogenic Disease, Nursing Service, Hospital, standards, Organizational Innovation, Quality of Health Care, trends, Total Quality Management, United States |
Drug-induced cognitive impairment in the elderly. | Moore AR, O'Keeffe ST | Drugs & aging | 1999 |
Aged, Anti-Inflammatory Agents, Non-Steroidal, adverse effects, Cholinergic Antagonists, adverse effects, Delirium, chemically induced, Dementia, chemically induced, Histamine H2 Antagonists, adverse effects, Humans, Psychotropic Drugs, adverse effects |
Clinical significance of delirium subtypes in older people. | O'Keeffe ST, Lavan JN | Age and ageing | 1999 |
Aged, Aged, 80 and over, Antipsychotic Agents, therapeutic use, Delirium, classification, Haloperidol, therapeutic use, Humans, Prospective Studies, Psychomotor Disorders, complications, Thioridazine, therapeutic use |
Validity of the confusion assessment method in detecting postoperative delirium in the elderly. | Rolfson DB, McElhaney JE, Jhangri GS, Rockwood K | International psychogeriatrics / IPA | 1999 |
Aged, Confusion, diagnosis, Coronary Artery Bypass, adverse effects, Delirium, diagnosis, Female, Humans, Male, Nursing Assessment, standards, Observer Variation, Postoperative Care, Predictive Value of Tests, Prospective Studies, Psychiatric Status Rating Scales, standards, ROC Curve, Reproducibility of Results, Sensitivity and Specificity |
Serum anticholinergic activity changes with acute illness in elderly medical patients. | Flacker JM, Lipsitz LA | The journals of gerontology. Series A, Biological sciences and medical sciences | 1999 |
Acute Disease, Aged, Aged, 80 and over, Analysis of Variance, Atropine, blood, Attention, physiology, Cholinergic Antagonists, blood, Cognition, physiology, Confusion, blood, Consciousness, physiology, Cross-Sectional Studies, Delirium, blood, Female, Fever, blood, Follow-Up Studies, Humans, Logistic Models, Male, Muscarinic Antagonists, blood, Quinuclidinyl Benzilate, diagnostic use, Radiopharmaceuticals, diagnostic use, Thinking, physiology, Tritium, diagnostic use |
Importance of serum anticholinergic activity in the assessment of elderly patients with delirium. | Mussi C, Ferrari R, Ascari S, Salvioli G | Journal of geriatric psychiatry and neurology | 1999 |
Aged, Aged, 80 and over, Anti-Bacterial Agents, therapeutic use, Antipsychotic Agents, adverse effects, Benzodiazepines, adverse effects, Body Weight, Cholinergic Antagonists, adverse effects, Cross-Sectional Studies, Delirium, etiology, Female, Humans, Male, Risk Factors |
Changing clinical practice through research: the case of delirium. | Lacko L, Bryan Y, Dellasega C, Salerno F | Clinical nursing research | 1999 |
Aged, Aged, 80 and over, Clinical Nursing Research, education, Clinical Protocols, standards, Delirium, diagnosis, Diffusion of Innovation, Female, Geriatric Assessment, Health Knowledge, Attitudes, Practice, Humans, Male, Mass Screening, methods, Nursing Assessment, methods, Nursing Staff, Hospital, education, Nursing Theory |
Delirium in the elderly. Optimal management. | Flacker JM, Marcantonio ER | Drugs & aging | 1998 |
Aged, Antipsychotic Agents, administration & dosage, Behavior Therapy, methods, Combined Modality Therapy, Counseling, Delirium, prevention & control, Guidelines as Topic, Humans, Risk Factors, Syndrome |
The time and change test: a simple screening test for dementia. | Inouye SK, Robison JT, Froehlich TE, Richardson ED | The journals of gerontology. Series A, Biological sciences and medical sciences | 1998 |
Activities of Daily Living, classification, Aged, Aged, 80 and over, Ambulatory Care Facilities, statistics & numerical data, Connecticut, epidemiology, Dementia, diagnosis, Female, Geriatric Assessment, statistics & numerical data, Humans, Incidence, Linear Models, Male, Mental Status Schedule, Primary Health Care, Prospective Studies, Psychometrics, Reproducibility of Results, Sensitivity and Specificity |
Prospective individual matching: covariate balance and power in a comparative study. | Makuch RW, Zhang Z, Charpentier PA, Inouye SK | Statistics in medicine | 1998 |
Analysis of Variance, Clinical Trials, Phase II as Topic, statistics & numerical data, Clinical Trials, Phase IV as Topic, statistics & numerical data, Humans, Matched-Pair Analysis, Randomized Controlled Trials as Topic, statistics & numerical data, Selection Bias |
Importance of functional measures in predicting mortality among older hospitalized patients. | Inouye SK, Peduzzi PN, Robison JT, Hughes JS, Horwitz RI, Concato J | JAMA | 1998 |
Activities of Daily Living, Aged, Connecticut, Cost of Illness, Female, Hospital Bed Capacity, 500 and over, Hospitalization, statistics & numerical data, Hospitals, University, Humans, Male, Mental Status Schedule, Models, Statistical, Mortality, Outcome Assessment (Health Care), statistics & numerical data, Prognosis, Proportional Hazards Models, Prospective Studies, Risk Assessment, Severity of Illness Index, Survival Analysis |
Delirium: comparison of four predictive models in hospitalized critically ill elderly patients. | Eden BM, Foreman MD, Sisk R | Applied nursing research : ANR | 1998 |
Aged, Aged, 80 and over, Algorithms, Case-Control Studies, Critical Care, Delirium, diagnosis, Discriminant Analysis, Female, Humans, Male, Middle Aged, Nursing Diagnosis, methods, Sensitivity and Specificity |
A case control study of falls in the hospital setting. | Ash KL, MacLeod P, Clark L | Journal of gerontological nursing | 1998 |
Accidental Falls, prevention & control, Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Child, Discriminant Analysis, Female, Hospitals, University, Humans, Male, Middle Aged, Nursing Records, Risk Factors, Risk Management, Saskatchewan, Wounds and Injuries, etiology |
Delirium risk factors in elderly hospitalized patients. | Elie M, Cole MG, Primeau FJ, Bellavance F | Journal of general internal medicine | 1998 |
Age Factors, Aged, Delirium, epidemiology, Female, Humans, Inpatients, Male, Risk Factors |
Delirium in hospitalized older patients: recognition and risk factors. | Inouye SK | Journal of geriatric psychiatry and neurology | 1998 |
Aged, Aged, 80 and over, Cohort Studies, Delirium, diagnosis, Female, Humans, Inpatients, Nutrition Disorders, physiopathology, Polypharmacy, Predictive Value of Tests, Primary Prevention, methods, Psychiatric Status Rating Scales, standards, Restraint, Physical, adverse effects, Risk Assessment, Risk Factors, Urinary Catheterization, adverse effects |
Immobility and falls. | Mahoney JE | Clinics in geriatric medicine | 1998 |
Accidental Falls, Aged, Aged, 80 and over, Hospitalization, Humans, Immobilization, adverse effects |
A nonpharmacologic sleep protocol for hospitalized older patients. | McDowell JA, Mion LC, Lydon TJ, Inouye SK | Journal of the American Geriatrics Society | 1998 |
Aged, Aged, 80 and over, Cohort Studies, Connecticut, Female, Geriatric Assessment, Hospitalization, Humans, Hypnotics and Sedatives, administration & dosage, Male, Prospective Studies, Sleep Initiation and Maintenance Disorders, nursing, Treatment Outcome |
Detection and diagnosis of delirium in the elderly: psychiatrist diagnosis, confusion assessment method, or consensus diagnosis? | Zou Y, Cole MG, Primeau FJ, McCusker J, Bellavance F, Laplante J | International psychogeriatrics / IPA | 1998 |
Aged, Aged, 80 and over, Confusion, diagnosis, Delirium, diagnosis, Female, Geriatric Assessment, Humans, Male, Mental Status Schedule, standards, Nurse Clinicians, Nursing Assessment, standards, Observer Variation, Psychiatry, Reproducibility of Results, Sensitivity and Specificity |
Reliability and validity of a new measure of severity of delirium. | McCusker J, Cole M, Bellavance F, Primeau F | International psychogeriatrics / IPA | 1998 |
Aged, Aged, 80 and over, Confidence Intervals, Delirium, diagnosis, Female, Geriatric Assessment, Humans, Male, Observer Variation, Prospective Studies, Psychiatric Status Rating Scales, standards, Psychometrics, standards, Reproducibility of Results, Severity of Illness Index |
Does delirium contribute to poor hospital outcomes? A three-site epidemiologic study. | Inouye SK, Rushing JT, Foreman MD, Palmer RM, Pompei P | Journal of general internal medicine | 1998 |
Activities of Daily Living, Aged, Delirium, Female, Hospital Mortality, Hospitalization, Humans, Male, Prognosis, Prospective Studies |
The impact of postoperative pain on the development of postoperative delirium. | Lynch EP, Lazor MA, Gellis JE, Orav J, Goldman L, Marcantonio ER | Anesthesia and analgesia | 1998 |
Activities of Daily Living, Age Factors, Aged, Alcoholism, complications, Analgesia, Analgesics, Opioid, administration & dosage, Blood Chemical Analysis, Cognition, Confusion, diagnosis, Delirium, diagnosis, Female, Humans, Incidence, Male, Medical Records, Middle Aged, Movement, Nursing Assessment, Odds Ratio, Pain Measurement, Pain, Postoperative, complications, Postoperative Complications, diagnosis, Prospective Studies, Rest, Risk Factors, Surgical Procedures, Operative |
The association of serum anticholinergic activity with delirium in elderly medical patients. | Flacker JM, Cummings V, Mach JR, Bettin K, Kiely DK, Wei J | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 1998 |
Aged, Aged, 80 and over, Boston, Cholinergic Antagonists, adverse effects, Cross-Sectional Studies, Delirium, blood, Female, Humans, Logistic Models, Male, Multivariate Analysis, Odds Ratio |