What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Impact of delirium on mortality and cognitive and functional performance among elderly people with femoral fractures. | Furlaneto ME, Garcez-Leme LE | Clinics (São Paulo, Brazil) | 2007 |
Activities of Daily Living, Aged, Aged, 80 and over, Cognition Disorders, etiology, Delirium, etiology, Epidemiologic Methods, Female, Femoral Fractures, complications, Geriatric Assessment, Humans, Male, Middle Aged |
| Antipsychotics in the treatment of delirium: a systematic review. | Seitz DP, Gill SS, van Zyl LT | The Journal of clinical psychiatry | 2007 |
Antipsychotic Agents, therapeutic use, Clinical Trials as Topic, Delirium, drug therapy, Humans, Treatment Outcome |
| Interventions for preventing delirium in hospitalised patients. | Siddiqi N, Stockdale R, Britton AM, Holmes J | The Cochrane database of systematic reviews | 2007 |
Anesthesia, Epidural, Anesthetics, Inhalation, Cytidine Diphosphate Choline, administration & dosage, Delirium, prevention & control, Halothane, Hospitalization, Humans, Indans, administration & dosage, Nootropic Agents, administration & dosage, Piperidines, administration & dosage |
| Antipsychotics for delirium. | Lonergan E, Britton AM, Luxenberg J, Wyller T | The Cochrane database of systematic reviews | 2007 |
Adult, Antipsychotic Agents, adverse effects, Benzodiazepines, adverse effects, Delirium, drug therapy, Female, Haloperidol, adverse effects, Humans, Male, Randomized Controlled Trials as Topic, Risperidone, adverse effects |
| The Montreal Cognitive Assessment: validity and utility in a memory clinic setting. | Smith T, Gildeh N, Holmes C | Canadian journal of psychiatry. Revue canadienne de psychiatrie | 2007 |
Aged, Aged, 80 and over, Alzheimer Disease, diagnosis, Cognition Disorders, diagnosis, Dementia, Vascular, diagnosis, England, Female, Follow-Up Studies, Humans, Male, Mass Screening, Memory Disorders, diagnosis, Mental Status Schedule, statistics & numerical data, Neuropsychological Tests, statistics & numerical data, Prospective Studies, Psychometrics, statistics & numerical data, Reproducibility of Results, Risk Assessment |
| Association between psychomotor activity delirium subtypes and mortality among newly admitted post-acute facility patients. | Kiely DK, Jones RN, Bergmann MA, Marcantonio ER | The journals of gerontology. Series A, Biological sciences and medical sciences | 2007 |
Activities of Daily Living, Aged, 80 and over, Boston, Confusion, etiology, Delirium, diagnosis, Female, Geriatric Assessment, Hospitalization, Humans, Kaplan-Meier Estimate, Male, Odds Ratio, Proportional Hazards Models, Prospective Studies, Psychomotor Performance, Questionnaires, Severity of Illness Index |
| Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. | Ely EW, Girard TD, Shintani AK, Jackson JC, Gordon SM, Thomason JW, Pun BT, Canonico AE, Light RW, Pandharipande P, Laskowitz DT | Critical care medicine | 2007 |
Aged, Apolipoprotein E4, genetics, Critical Illness, epidemiology, Delirium, diagnosis, Factor Analysis, Statistical, Female, Gene Frequency, genetics, Genetic Predisposition to Disease, epidemiology, Genotype, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Polymerase Chain Reaction, Polymorphism, Genetic, genetics, Predictive Value of Tests, Prospective Studies, Restriction Mapping, Risk Factors, Sensitivity and Specificity, Single-Blind Method, Tennessee, epidemiology, Time Factors |
| Common problems in hospitalized older adults. | Palmisano-Mills C | Journal of gerontological nursing | 2007 |
Accidental Falls, prevention & control, Activities of Daily Living, Aged, Connecticut, epidemiology, Dehydration, epidemiology, Delirium, epidemiology, Geriatric Assessment, Geriatric Nursing, organization & administration, Health Services Research, Hospital Units, organization & administration, Hospitalization, statistics & numerical data, Humans, Inpatients, statistics & numerical data, Length of Stay, Malnutrition, epidemiology, Models, Nursing, Models, Organizational, Morbidity, Nursing Assessment, Nursing Evaluation Research, Patient Care Team, organization & administration, Questionnaires, Sleep Deprivation, epidemiology, Total Quality Management, organization & administration |
| Prevalence and outcomes of delirium in community and non-acute care settings in people without dementia: a report from the Canadian Study of Health and Aging. | Andrew MK, Freter SH, Rockwood K | BMC medicine | 2006 |
Aged, Canada, Cognition Disorders, epidemiology, Community Health Services, statistics & numerical data, Delirium, epidemiology, Frail Elderly, Humans, Long-Term Care, Survival Analysis, Treatment Outcome |
| The role of neuroimaging in elucidating delirium pathophysiology. | Alsop DC, Fearing MA, Johnson K, Sperling R, Fong TG, Inouye SK | The journals of gerontology. Series A, Biological sciences and medical sciences | 2006 |
Blood-Brain Barrier, Brain, pathology, Cerebrovascular Circulation, Delirium, diagnosis, Diagnostic Imaging, Humans, Magnetic Resonance Imaging, Organ Size, Positron-Emission Tomography, Tomography, Emission-Computed, Single-Photon |
| Elucidating the pathophysiology of delirium and the interrelationship of delirium and dementia. | Inouye SK, Ferrucci L | The journals of gerontology. Series A, Biological sciences and medical sciences | 2006 |
Delirium, physiopathology, Dementia, physiopathology, Humans |
| Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT. | Fong TG, Bogardus ST, Daftary A, Auerbach E, Blumenfeld H, Modur S, Leo-Summers L, Seibyl J, Inouye SK | The journals of gerontology. Series A, Biological sciences and medical sciences | 2006 |
Aged, Aged, 80 and over, Cerebrovascular Circulation, physiology, Delirium, physiopathology, Female, Frontal Lobe, blood supply, Humans, Male, Parietal Lobe, blood supply, Radiopharmaceuticals, diagnostic use, Regional Blood Flow, physiology, Technetium Tc 99m Exametazime, diagnostic use, Tomography, Emission-Computed, Single-Photon |
| Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. | Xie Z, Dong Y, Maeda U, Moir R, Inouye SK, Culley DJ, Crosby G, Tanzi RE | The journals of gerontology. Series A, Biological sciences and medical sciences | 2006 |
Amyloid beta-Protein Precursor, analysis, Anesthetics, Inhalation, adverse effects, Apoptosis, drug effects, Blotting, Western, Cells, Cultured, Delirium, pathology, Dementia, pathology, Humans, Isoflurane, adverse effects, Neuroglia, drug effects |
| Suburban leptospirosis: atypical lymphocytosis and gamma-delta T cell response. | Barry M, Wisnewski AV, Matthias MA, Inouye SK, Vinetz JM | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | 2006 |
Animals, Canada, epidemiology, Dogs, Leptospirosis, complications, Lymphocytosis, etiology, Mephitidae, New England, epidemiology, Raccoons, T-Lymphocytes, immunology |
| Older adults discharged from the hospital with delirium: 1-year outcomes. | McAvay GJ, Van Ness PH, Bogardus ST, Zhang Y, Leslie DL, Leo-Summers LS, Inouye SK | Journal of the American Geriatrics Society | 2006 |
Aged, Aged, 80 and over, Delirium, mortality, Female, Follow-Up Studies, Geriatric Assessment, methods, Health Status Indicators, Humans, Male, Nursing Homes, statistics & numerical data, Outcome Assessment (Health Care), Patient Discharge, statistics & numerical data, Retrospective Studies, Risk Factors, Survival Rate, trends, Time Factors, United States, epidemiology |
| The roles of senior management in improving hospital experiences for frail older adults. | Bradley EH, Webster TR, Schlesinger M, Baker D, Inouye SK | Journal of healthcare management / American College of Healthcare Executives | 2006 |
Aged, Data Collection, Geriatric Nursing, Hospital Administrators, Humans, Interviews as Topic, Patient Satisfaction, statistics & numerical data, Professional Role, United States |
| Replicating the Hospital Elder Life Program in a community hospital and demonstrating effectiveness using quality improvement methodology. | Rubin FH, Williams JT, Lescisin DA, Mook WJ, Hassan S, Inouye SK | Journal of the American Geriatrics Society | 2006 |
Activities of Daily Living, Aged, Aged, 80 and over, Delirium, therapy, Female, Geriatric Assessment, Geriatrics, standards, Hospitals, Community, standards, Humans, Male, Outcome and Process Assessment (Health Care), organization & administration, Patient Care Planning, organization & administration, Patient Satisfaction, Quality of Health Care, trends, Total Quality Management, organization & administration |
| Patterns of diffusion of evidence-based clinical programmes: a case study of the Hospital Elder Life Program. | Bradley EH, Webster TR, Schlesinger M, Baker D, Inouye SK | Quality & safety in health care | 2006 |
Aged, Cross-Sectional Studies, Delirium, therapy, Diffusion of Innovation, Evidence-Based Medicine, statistics & numerical data, Geriatrics, standards, Guideline Adherence, Hospitals, classification, Humans, Information Dissemination, Organizational Case Studies, Outcome Assessment (Health Care), Practice Guidelines as Topic, Program Development, statistics & numerical data, Program Evaluation, United States |
| Recoverable cognitive dysfunction at hospital admission in older persons during acute illness. | Inouye SK, Zhang Y, Han L, Leo-Summers L, Jones R, Marcantonio E | Journal of general internal medicine | 2006 |
Activities of Daily Living, Acute Disease, mortality, Aged, Aged, 80 and over, Cognition Disorders, complications, Cohort Studies, Delirium, complications, Dementia, complications, Educational Status, Female, Hospitalization, statistics & numerical data, Humans, Incidence, Male, Predictive Value of Tests, Prospective Studies, Psychiatric Status Rating Scales, Recovery of Function, Severity of Illness Index |
| Serum biomarkers for delirium. | Marcantonio ER, Rudolph JL, Culley D, Crosby G, Alsop D, Inouye SK | The journals of gerontology. Series A, Biological sciences and medical sciences | 2006 |
Acetylcholine, blood, Amino Acids, blood, Biological Markers, blood, Cholinergic Antagonists, blood, Delirium, blood, Genetic Markers, Humans, Melatonin, blood, Serotonin, blood |
| Psychiatric side effects of interferon treatment. | Patten SB | Current drug safety | 2006 |
Hepatitis C, drug therapy, Humans, Immunologic Factors, adverse effects, Interferon-alpha, adverse effects, Interferon-beta, adverse effects, Multiple Sclerosis, drug therapy, Neoplasms, drug therapy, Neurotoxicity Syndromes, etiology |
| Frequency of delirium in a neurological emergency room. | Ramirez-Bermudez J, Lopez-Gómez M, Sosa Ana L, Aceves S, Nader-Kawachi J, Nicolini H | The Journal of neuropsychiatry and clinical neurosciences | 2006 |
Adult, Aged, Arousal, physiology, Brain Diseases, complications, Coma, epidemiology, Cross-Sectional Studies, Delirium, epidemiology, Dominance, Cerebral, physiology, Emergency Service, Hospital, statistics & numerical data, Female, Frontal Lobe, physiopathology, Health Surveys, Humans, Male, Mexico, epidemiology, Middle Aged, Neuropsychological Tests, Psychomotor Performance, physiology, Temporal Lobe, physiopathology |
| IPA survey of brief cognitive screening instruments. | Shulman KI, Herrmann N, Brodaty H, Chiu H, Lawlor B, Ritchie K, Scanlan JM | International psychogeriatrics / IPA | 2006 |
Adult, Aged, Cognition, Cognition Disorders, diagnosis, Female, Geriatric Psychiatry, organization & administration, Health Personnel, Health Surveys, Humans, Male, Mass Screening, methods, Middle Aged, Psychological Tests |
| Impaired executive function is associated with delirium after coronary artery bypass graft surgery. | Rudolph JL, Jones RN, Grande LJ, Milberg WP, King EG, Lipsitz LA, Levkoff SE, Marcantonio ER | Journal of the American Geriatrics Society | 2006 |
Aged, Cognition, physiology, Cognition Disorders, etiology, Coronary Artery Bypass, adverse effects, Delirium, complications, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Postoperative Complications, Prognosis, Prospective Studies, Risk Factors |
| Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006: diagnosis and management. | Arnold JM, Liu P, Demers C, Dorian P, Giannetti N, Haddad H, Heckman GA, Howlett JG, Ignaszewski A, Johnstone DE, Jong P, McKelvie RS, Moe GW, Parker JD, Rao V, Ross HJ, Sequeira EJ, Svendsen AM, Teo K, Tsuyuki RT, White M, | The Canadian journal of cardiology | 2006 |
Canada, Cardiac Surgical Procedures, methods, Cardiology, Cardiovascular Agents, therapeutic use, Defibrillators, Implantable, Exercise Therapy, methods, Heart Failure, diagnosis, Humans, Societies, Medical |
| Does home treatment affect delirium? A randomised controlled trial of rehabilitation of elderly and care at home or usual treatment (The REACH-OUT trial). | Caplan GA, Coconis J, Board N, Sayers A, Woods J | Age and ageing | 2006 |
Aged, Delirium, etiology, Female, Follow-Up Studies, Health Status, Home Care Services, Hospitalization, Humans, Male, Patient Satisfaction, Psychiatric Status Rating Scales, Questionnaires, Retrospective Studies, Treatment Outcome |
| Early evaluation of the risk of functional decline following hospitalization of older patients: development of a predictive tool. | Cornette P, Swine C, Malhomme B, Gillet JB, Meert P, D'Hoore W | European journal of public health | 2006 |
Activities of Daily Living, Aged, Aged, 80 and over, Cohort Studies, Female, Frail Elderly, Humans, Interviews as Topic, Male, Patient Discharge, Prospective Studies, Risk Assessment |
| Delirium concisely: condition is associated with increased morbidity, mortality, and length of hospitalization. | van Zyl LT, Seitz DP | Geriatrics | 2006 |
Aged, Antipsychotic Agents, therapeutic use, Combined Modality Therapy, Delirium, complications, Dementia, etiology, Female, Geriatric Assessment, statistics & numerical data, Hospital Mortality, Humans, Institutionalization, statistics & numerical data, Length of Stay, statistics & numerical data, Male, Outcome Assessment (Health Care), Risk |
| Influence of prior cognitive impairment on the severity of delirium symptoms among older patients. | Voyer P, McCusker J, Cole MG, Khomenko L | The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses | 2006 |
Aged, Aged, 80 and over, Cognition Disorders, epidemiology, Delirium, diagnosis, Dementia, epidemiology, Female, Humans, Male, Movement Disorders, diagnosis, Neuropsychological Tests, Prevalence, Severity of Illness Index, Socioeconomic Factors |
| Multicomponent geriatric intervention for elderly inpatients with delirium: a randomized, controlled trial. | Pitkälä KH, Laurila JV, Strandberg TE, Tilvis RS | The journals of gerontology. Series A, Biological sciences and medical sciences | 2006 |
Aged, Aged, 80 and over, Antipsychotic Agents, therapeutic use, Cholinesterase Inhibitors, therapeutic use, Delirium, therapy, Female, Humans, Inpatients, Male, Physical Therapy Modalities, Referral and Consultation, Treatment Outcome |
| Delirium within three days of stroke in a cohort of elderly patients. | Sheng AZ, Shen Q, Cordato D, Zhang YY, Yin Chan DK | Journal of the American Geriatrics Society | 2006 |
Age Factors, Aged, Aged, 80 and over, Delirium, epidemiology, Female, Follow-Up Studies, Humans, Incidence, Length of Stay, Male, New South Wales, epidemiology, Odds Ratio, Prognosis, Prospective Studies, Risk Factors, Stroke, complications, Survival Rate, Time Factors |
| Delirium in older patients admitted to general internal medicine. | Edlund A, Lundström M, Karlsson S, Brännström B, Bucht G, Gustafson Y | Journal of geriatric psychiatry and neurology | 2006 |
Aged, Aged, 80 and over, Delirium, diagnosis, Female, Hospitals, General, Humans, Internal Medicine, Length of Stay, Male, Patient Admission, Psychiatric Status Rating Scales, Survival Rate, Sweden, epidemiology, Time Factors |
| Assessment and discharge planning for hospitalized older adults with delirium. | Cole CS, Williams EB, Williams RD | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | 2006 |
Aged, Aged, 80 and over, Delirium, diagnosis, Female, Geriatric Assessment, methods, Humans, Needs Assessment, organization & administration, Nurse’s Role, Nursing Assessment, methods, Patient Care Planning, Patient Discharge, Risk Assessment, methods, Safety Management |
| Risperidone versus olanzapine for the treatment of delirium. | Kim SW, Yoo JA, Lee SY, Kim SY, Bae KY, Yang SJ, Kim JM, Shin IS, Yoon JS | Human psychopharmacology | 2010 |
Adult, Aged, 80 and over, Antipsychotic Agents, adverse effects, Benzodiazepines, adverse effects, Data Interpretation, Statistical, Delirium, drug therapy, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Male, Risperidone, adverse effects, Treatment Outcome |
| Incidence and predictors of delirium after cardiac surgery: Results from The IPDACS Study. | Kazmierski J, Kowman M, Banach M, Fendler W, Okonski P, Banys A, Jaszewski R, Rysz J, Mikhailidis DP, Sobow T, Kloszewska I, | Journal of psychosomatic research | 2010 |
Age Factors, Aged, Anemia, epidemiology, Atrial Fibrillation, epidemiology, Cardiopulmonary Bypass, psychology, Comorbidity, Cross-Sectional Studies, Delirium, epidemiology, Depressive Disorder, Major, diagnosis, Female, Health Status Indicators, Heart Diseases, psychology, Humans, Incidence, Male, Mental Disorders, epidemiology, Mental Status Schedule, Postoperative Complications, epidemiology, Risk Factors |
| Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis. | Witlox J, Eurelings LS, de Jonghe JF, Kalisvaart KJ, Eikelenboom P, van Gool WA | JAMA : the journal of the American Medical Association | 2010 |
Aged, Aged, 80 and over, Case-Control Studies, Confounding Factors (Epidemiology), Delirium, complications, Dementia, complications, Humans, Institutionalization, statistics & numerical data, Odds Ratio |
| Serum S100B in elderly patients with and without delirium. | van Munster BC, Korevaar JC, Korse CM, Bonfrer JM, Zwinderman AH, de Rooij SE | International journal of geriatric psychiatry | 2010 |
Age Factors, Aged, Aged, 80 and over, Biological Markers, blood, Cognition Disorders, blood, Delirium, blood, Female, Humans, Male, Psychiatric Status Rating Scales, S100 Proteins, blood |
| A national survey of the management of delirium in UK intensive care units. | Mac Sweeney R, Barber V, Page V, Ely EW, Perkins GD, Young JD, McAuley DF, | QJM : monthly journal of the Association of Physicians | 2010 |
Antipsychotic Agents, therapeutic use, Delirium, diagnosis, Delivery of Health Care, standards, Great Britain, Haloperidol, therapeutic use, Humans, Intensive Care Units, standards, Questionnaires |
| Delirium following acute myocardial infarction: incidence, clinical profiles, and predictors. | Uguz F, Kayrak M, Cíçek E, Kayhan F, Ari H, Altunbas G | Perspectives in psychiatric care | 2010 |
Case-Control Studies, Chi-Square Distribution, Delirium, diagnosis, Female, Heart Arrest, complications, Hospitals, University, Humans, Hyperkalemia, blood, Incidence, Length of Stay, statistics & numerical data, Male, Middle Aged, Myocardial Infarction, complications, Predictive Value of Tests, Prevalence, Risk Factors, Severity of Illness Index, Socioeconomic Factors, Statistics, Nonparametric, Turkey, epidemiology |
| Neuroleptic dose in the management of delirium in patients with advanced cancer. | Hui D, Bush SH, Gallo LE, Palmer JL, Yennurajalingam S, Bruera E | Journal of pain and symptom management | 2010 |
Adult, Affective Symptoms, psychology, Aged, Aged, 80 and over, Algorithms, Antipsychotic Agents, administration & dosage, Delirium, drug therapy, Dose-Response Relationship, Drug, Female, Haloperidol, administration & dosage, Humans, Male, Mental Recall, Middle Aged, Neoplasms, complications, Neuropsychological Tests, Psychiatric Status Rating Scales |
| Impaired mobility, ASA status and administration of tramadol are risk factors for postoperative delirium in patients aged 75 years or more after major abdominal surgery. | Brouquet A, Cudennec T, Benoist S, Moulias S, Beauchet A, Penna C, Teillet L, Nordlinger B | Annals of surgery | 2010 |
Abdomen, surgery, Aged, Aged, 80 and over, Analgesics, Opioid, adverse effects, Cognition, Delirium, diagnosis, Geriatric Assessment, Health Status, Humans, Mental Status Schedule, Mobility Limitation, Postoperative Complications, etiology, Risk Factors, Tramadol, adverse effects |
| Does this patient have delirium?: value of bedside instruments. | Wong CL, Holroyd-Leduc J, Simel DL, Straus SE | JAMA | 2010 |
Aged, Delirium, diagnosis, Diagnostic and Statistical Manual of Mental Disorders, Humans, Mental Status Schedule, Point-of-Care Systems, Prospective Studies, Sensitivity and Specificity |
| Randomized trial of a delirium abatement program for postacute skilled nursing facilities. | Marcantonio ER, Bergmann MA, Kiely DK, Orav EJ, Jones RN | Journal of the American Geriatrics Society | 2010 |
Aged, 80 and over, Chi-Square Distribution, Delirium, diagnosis, Female, Humans, Logistic Models, Male, Mental Status Schedule, Nursing Assessment, Nursing Diagnosis, Skilled Nursing Facilities, Treatment Outcome |
| Cortisol, interleukins and S100B in delirium in the elderly. | van Munster BC, Bisschop PH, Zwinderman AH, Korevaar JC, Endert E, Wiersinga WJ, van Oosten HE, Goslings JC, de Rooij SE | Brain and cognition | 2010 |
Aged, Aged, 80 and over, Biological Markers, blood, Delirium, blood, Female, Hip Fractures, blood, Humans, Hydrocortisone, blood, Immunoassay, Interleukin-6, blood, Interleukin-8, blood, Male, Nerve Growth Factors, blood, S100 Calcium Binding Protein beta Subunit, S100 Proteins, blood |
| Prevalence of delirium on admission to postacute care is associated with a higher number of nursing home deficiencies. | Jones RN, Kiely DK, Marcantonio ER | Journal of the American Medical Directors Association | 2010 |
Acute Disease, Aged, Boston, epidemiology, Delirium, diagnosis, Humans, Mass Screening, Patient Admission, Quality of Health Care, Randomized Controlled Trials as Topic, Skilled Nursing Facilities, standards, United States, epidemiology |
| Validating a new clinical subtyping scheme for delirium with electronic motion analysis. | Godfrey A, Leonard M, Donnelly S, Conroy M, Olaighin G, Meagher D | Psychiatry research | 2010 |
Accelerometry, Adult, Aged, Aged, 80 and over, Checklist, Delirium, classification, Diagnosis, Computer-Assisted, instrumentation, Female, Humans, Male, Middle Aged, Movement, Neuropsychological Tests, Psychiatric Status Rating Scales |
| Potentially inappropriate medication use in older adults with mild cognitive impairment. | Weston AL, Weinstein AM, Barton C, Yaffe K | The journals of gerontology. Series A, Biological sciences and medical sciences | 2010 |
Aged, California, epidemiology, Cognition Disorders, drug therapy, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Male, Medication Errors, statistics & numerical data, Prevalence, Prognosis, Retrospective Studies, Risk Factors |
| Delirium in intensive care unit patients. | van Eijk MM, Slooter AJ | Seminars in cardiothoracic and vascular anesthesia | 2010 |
Cardiac Surgical Procedures, adverse effects, Critical Illness, Delirium, diagnosis, Humans, Intensive Care, methods, Intensive Care Units, statistics & numerical data, Length of Stay, Postoperative Complications, diagnosis |
| Factors associated with persistent delirium after intensive care unit admission in an older medical patient population. | Pisani MA, Murphy TE, Araujo KL, Van Ness PH | Journal of critical care | 2010 |
Age Factors, Aged, Analgesics, Opioid, adverse effects, Analysis of Variance, Delirium, chemically induced, Dementia, epidemiology, Haloperidol, adverse effects, Humans, Intensive Care, Intensive Care Units, Middle Aged, Patient Admission, Prospective Studies, Psychotropic Drugs, adverse effects, Risk Factors, Severity of Illness Index |
| Incidence, prevalence, and under-recognition of delirium in urology patients. | Vollmer CM, Bond J, Eden BM, Resch DS, Fulk L, Robinson S, Hughes LE | Urologic nursing | 2010 |
Age Distribution, Aged, Aged, 80 and over, Comorbidity, Delirium, diagnosis, Documentation, Female, Humans, Incidence, Inpatients, statistics & numerical data, Length of Stay, statistics & numerical data, Male, Middle Aged, Midwestern United States, epidemiology, Nursing Assessment, methods, Nursing Records, Prevalence, Prospective Studies, Risk Factors, Sex Distribution, Urologic Diseases, complications |
| Delirium in older cardiac surgery patients: directions for practice. | Clarke SP, McRae ME, Del Signore S, Schubert M, Styra R | Journal of gerontological nursing | 2010 |
Aged, Delirium, complications, Humans, Monitoring, Physiologic, Thoracic Surgery |
| Delirium superimposed on dementia. Assessment and intervention. | Flanagan NM, Fick DM | Journal of gerontological nursing | 2010 |
Aged, Delirium, complications, Dementia, complications, Humans, Nursing Assessment |
| A systematic review of the reliability of screening for cognitive impairment in older adults by use of standardised assessment tools administered via the telephone. | Martin-Khan M, Wootton R, Gray L | Journal of telemedicine and telecare | 2010 |
Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Delirium, diagnosis, Evaluation Studies as Topic, Geriatric Assessment, methods, Humans, Neuropsychological Tests, Psychiatric Status Rating Scales, Reproducibility of Results, Severity of Illness Index, Telephone |
| Brief cognitive screening instruments: an update. | Ismail Z, Rajji TK, Shulman KI | International journal of geriatric psychiatry | 2010 |
Aged, Aged, 80 and over, Attitude of Health Personnel, Cognition Disorders, diagnosis, Dementia, diagnosis, Female, Geriatric Assessment, methods, Great Britain, Humans, Male, Mass Screening, instrumentation, Primary Health Care, Psychometrics, methods |
| Screening and case finding tools for the detection of dementia. Part I: evidence-based meta-analysis of multidomain tests. | Mitchell AJ, Malladi S | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2010 |
Aged, Case Management, organization & administration, Cognition, Dementia, diagnosis, Evaluation Studies as Topic, Evidence-Based Medicine, instrumentation, Executive Function, Geriatric Assessment, methods, Humans, Intelligence Tests, standards, Interviews as Topic, standards, Mass Screening, instrumentation, Memory Disorders, diagnosis, Mental Recall, Mental Status Schedule, Meta-Analysis as Topic, Primary Health Care, methods, Reproducibility of Results, Severity of Illness Index |
| Delirium as a predictor of sepsis in post-coronary artery bypass grafting patients: a retrospective cohort study. | Martin BJ, Buth KJ, Arora RC, Baskett RJ | Critical care (London, England) | 2010 |
Aged, Cohort Studies, Coronary Artery Bypass, adverse effects, Delirium, diagnosis, Female, Humans, Male, Postoperative Complications, diagnosis, Predictive Value of Tests, Prospective Studies, Retrospective Studies, Sepsis, diagnosis, Treatment Outcome |
| Inflammation and cortisol response in coronary artery disease. | Nijm J, Jonasson L | Annals of medicine | 2009 |
Autoimmunity, Biological Markers, blood, Coronary Artery Disease, blood, Glucocorticoids, blood, Humans, Hydrocortisone, blood, Hypothalamo-Hypophyseal System, physiopathology, Inflammation, immunology, Myocardial Infarction, blood, Neuroimmunomodulation, Pituitary-Adrenal System, physiopathology, Stress, Physiological |
| Validation of a German version of the Confusion Assessment Method for delirium detection in a sample of acute geriatric patients with a high prevalence of dementia. | Hestermann U, Backenstrass M, Gekle I, Hack M, Mundt C, Oster P, Thomas C | Psychopathology | 2009 |
Acute Disease, Aged, Aged, 80 and over, Algorithms, Comorbidity, Confusion, diagnosis, Delirium, diagnosis, Dementia, diagnosis, Diagnosis, Differential, Diagnostic and Statistical Manual of Mental Disorders, Female, Frail Elderly, psychology, Germany, Hospitalization, Humans, Male, Mental Status Schedule, statistics & numerical data, Neuropsychological Tests, statistics & numerical data, Personality Assessment, statistics & numerical data, Psychometrics, statistics & numerical data, Reproducibility of Results, Risk Factors |
| Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population. | Pisani MA, Murphy TE, Araujo KL, Slattum P, Van Ness PH, Inouye SK | Critical care medicine | 2009 |
Aged, Analgesics, Opioid, adverse effects, Benzodiazepines, adverse effects, Delirium, epidemiology, Female, Humans, Intensive Care Units, Male, Prospective Studies, Time Factors |
| The ironic business case for chronic care in the acute care setting. | Siu AL, Spragens LH, Inouye SK, Morrison RS, Leff B | Health affairs (Project Hope) | 2009 |
Chronic Disease, therapy, Economics, Hospital, organization & administration, Emergency Service, Hospital, Humans, Quality of Health Care, United States |
| Microemboli are not associated with delirium after coronary artery bypass graft surgery. | Rudolph JL, Babikian VL, Treanor P, Pochay VE, Wigginton JB, Crittenden MD, Marcantonio ER | Perfusion | 2009 |
Aged, Aged, 80 and over, Cerebrum, pathology, Coronary Artery Bypass, adverse effects, Delirium, etiology, Embolism, etiology, Female, Humans, Male, Middle Aged |
| Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. | Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, Whitten P, Margolis BD, Byrne DW, Ely EW, Rocha MG, | JAMA : the journal of the American Medical Association | 2009 |
APACHE, Adrenergic alpha-Agonists, administration & dosage, Aged, Conscious Sedation, methods, Critical Illness, Delirium, epidemiology, Dexmedetomidine, administration & dosage, Double-Blind Method, Female, GABA Modulators, administration & dosage, Humans, Hypnotics and Sedatives, administration & dosage, Intensive Care Units, Kaplan-Meier Estimate, Length of Stay, Male, Midazolam, administration & dosage, Middle Aged, Prospective Studies, Respiration, Artificial |
| Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. | Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister KE, Hall JB, Kress JP | Lancet | 2009 |
Activities of Daily Living, Adult, Aged, Bed Rest, adverse effects, Chicago, Conscious Sedation, adverse effects, Critical Care, methods, Critical Illness, rehabilitation, Delirium, etiology, Early Ambulation, methods, Exercise Therapy, methods, Female, Humans, Iowa, Kaplan-Meier Estimate, Logistic Models, Male, Middle Aged, Mobility Limitation, Occupational Therapy, methods, Proportional Hazards Models, Respiration, Artificial, adverse effects, Single-Blind Method, Statistics, Nonparametric, Time Factors, Treatment Outcome |
| The genetics of deliria. | Adamis D, Van Munster BC, Macdonald AJ | International review of psychiatry (Abingdon, England) | 2009 |
Apolipoproteins E, genetics, Brain, metabolism, Catechol O-Methyltransferase, genetics, Delirium, epidemiology, Female, Genotype, Glutamic Acid, metabolism, Humans, Male, Polymorphism, Genetic, genetics, Substance-Related Disorders, metabolism |
| The neuropsychopharmacology of fronto-executive function: monoaminergic modulation. | Robbins TW, Arnsten AF | Annual review of neuroscience | 2009 |
Animals, Catecholamines, metabolism, Cognition, physiology, Delirium, Dementia, Amnestic, Cognitive Disorders, metabolism, Humans, Mental Processes, physiology, Neuropharmacology, methods, Prefrontal Cortex, anatomy & histology, Psychomotor Performance, physiology, Serotonin, metabolism, Synaptic Transmission, physiology |
| Derivation and validation of a preoperative prediction rule for delirium after cardiac surgery. | Rudolph JL, Jones RN, Levkoff SE, Rockett C, Inouye SK, Sellke FW, Khuri SF, Lipsitz LA, Ramlawi B, Levitsky S, Marcantonio ER | Circulation | 2009 |
Aged, Aged, 80 and over, Cardiac Surgical Procedures, adverse effects, Cohort Studies, Delirium, diagnosis, Female, Humans, Male, Postoperative Complications, diagnosis, Predictive Value of Tests, Preoperative Care, methods, Prospective Studies, Risk Factors |
| Delirium in older emergency department patients: recognition, risk factors, and psychomotor subtypes. | Han JH, Zimmerman EE, Cutler N, Schnelle J, Morandi A, Dittus RS, Storrow AB, Ely EW | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine | 2009 |
Aged, Aged, 80 and over, Cross-Sectional Studies, Delirium, diagnosis, Emergency Service, Hospital, Female, Geriatric Assessment, Humans, Logistic Models, Male, Medical Errors, prevention & control, Mental Status Schedule, Prospective Studies, Psychomotor Agitation, ROC Curve, Risk Assessment, Risk Factors, Sensitivity and Specificity, Statistics, Nonparametric |
| Predictors of falls and hospitalization outcomes in elderly patients admitted to an acute geriatric unit. | Corsinovi L, Bo M, Ricauda Aimonino N, Marinello R, Gariglio F, Marchetto C, Gastaldi L, Fissore L, Zanocchi M, Molaschi M | Archives of gerontology and geriatrics | 2009 |
Accidental Falls, statistics & numerical data, Acute Disease, Aged, Catchment Area (Health), Female, Health Services for the Aged, Hospitalization, statistics & numerical data, Humans, Italy, epidemiology, Male, Patient Admission, statistics & numerical data, Prospective Studies |
| Persistent delirium in older hospital patients: a systematic review of frequency and prognosis. | Cole MG, Ciampi A, Belzile E, Zhong L | Age and ageing | 2009 |
Aged, Aged, 80 and over, Delirium, diagnosis, Geriatric Assessment, Humans, Inpatients, Middle Aged, Prevalence, Prognosis |
| Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass. | Hudetz JA, Patterson KM, Iqbal Z, Gandhi SD, Byrne AJ, Hudetz AG, Warltier DC, Pagel PS | Journal of cardiothoracic and vascular anesthesia | 2009 |
Aged, Aged, 80 and over, Cardiac Surgical Procedures, adverse effects, Cardiopulmonary Bypass, adverse effects, Delirium, etiology, Humans, Inflammation Mediators, therapeutic use, Ketamine, therapeutic use, Male, Middle Aged, Postoperative Complications, etiology, Prospective Studies, Time Factors |
| Delirium and long-term cognitive impairment. | MacLullich AM, Beaglehole A, Hall RJ, Meagher DJ | International review of psychiatry (Abingdon, England) | 2009 |
Cognition Disorders, diagnosis, Delirium, epidemiology, Humans, Neuropsychological Tests, Time Factors |
| Cross validation of the Montreal Cognitive Assessment in community dwelling older adults residing in the Southeastern US. | Luis CA, Keegan AP, Mullan M | International journal of geriatric psychiatry | 2009 |
Aged, Aged, 80 and over, Alzheimer Disease, diagnosis, Cognition Disorders, diagnosis, Cohort Studies, Female, Humans, Male, Mass Screening, methods, Neuropsychological Tests, standards, Prospective Studies, ROC Curve, Reproducibility of Results, Sensitivity and Specificity, United States |
| An intervention integrated into daily clinical practice reduces the incidence of delirium during hospitalization in elderly patients. | Vidán MT, Sánchez E, Alonso M, Montero B, Ortiz J, Serra JA | Journal of the American Geriatrics Society | 2009 |
APACHE, Activities of Daily Living, classification, Aged, Aged, 80 and over, Combined Modality Therapy, Cooperative Behavior, Cross-Sectional Studies, Delirium, epidemiology, Female, Hospitalization, Humans, Incidence, Inservice Training, Interdisciplinary Communication, Male, Mental Status Schedule, Patient Care Team, Risk Factors, Spain |
| Postoperative delirium in the elderly surgical patient. | Sieber FE | Anesthesiology clinics | 2009 |
Aged, Anesthesia, Arthroplasty, Replacement, Hip, Delirium, diagnosis, Female, Femoral Neck Fractures, surgery, Humans, Postoperative Complications, psychology, Pulmonary Disease, Chronic Obstructive, complications |
| Fascia iliaca block prophylaxis for hip fracture patients at risk for delirium: a randomized placebo-controlled study. | Mouzopoulos G, Vasiliadis G, Lasanianos N, Nikolaras G, Morakis E, Kaminaris M | Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology | 2009 |
Aged, Anesthetics, Local, administration & dosage, Bupivacaine, administration & dosage, Delirium, diagnosis, Female, Fracture Fixation, Internal, adverse effects, Hip Fractures, complications, Humans, Male, Nerve Block, methods, Pain, etiology, Perioperative Care, methods, Prospective Studies, Risk Assessment, Severity of Illness Index, Treatment Outcome |
| Days of delirium are associated with 1-year mortality in an older intensive care unit population. | Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH | American journal of respiratory and critical care medicine | 2009 |
Aged, Cohort Studies, Connecticut, epidemiology, Delirium, epidemiology, Female, Follow-Up Studies, Geriatric Assessment, methods, Humans, Intensive Care Units, statistics & numerical data, Kaplan-Meier Estimate, Male, Prospective Studies, Risk Factors, Time Factors |
| Effects of an interdisciplinary nurse-led Delirium Prevention and Management Program (DPMP) on nursing workload: a pilot study. | Pretto M, Spirig R, Milisen K, Degeest S, Regazzoni P, Hasemann W | International journal of nursing studies | 2009 |
Aged, Aged, 80 and over, Delirium, complications, Female, Hip Fractures, complications, Humans, Male, Nursing, Pilot Projects, Workload |
| Predisposing factors associated with delirium among demented long-term care residents. | Voyer P, Richard S, Doucet L, Carmichael PH | Clinical nursing research | 2009 |
Aged, Cross-Sectional Studies, Delirium, complications, Dementia, complications, Disease Susceptibility, Humans, Likelihood Functions, Long-Term Care, Nursing Homes, Quebec |
| The overlap syndrome of depression and delirium in older hospitalized patients. | Givens JL, Jones RN, Inouye SK | Journal of the American Geriatrics Society | 2009 |
Academic Medical Centers, Activities of Daily Living, Aged, Aged, 80 and over, Connecticut, epidemiology, Delirium, complications, Depression, complications, Female, Geriatric Assessment, Hospitalization, statistics & numerical data, Humans, Incidence, Logistic Models, Male, Predictive Value of Tests, Prevalence, Proportional Hazards Models, Prospective Studies, Psychiatric Status Rating Scales |
| Risk factors for preoperative and postoperative delirium in elderly patients with hip fracture. | Juliebø V, Bjøro K, Krogseth M, Skovlund E, Ranhoff AH, Wyller TB | Journal of the American Geriatrics Society | 2009 |
Activities of Daily Living, Aged, Aged, 80 and over, Comorbidity, Delirium, epidemiology, Female, Hip Fractures, complications, Humans, Logistic Models, Male, Norway, epidemiology, Postoperative Complications, epidemiology, Prospective Studies, Risk Factors, Statistics, Nonparametric, Time Factors |
| Persistent delirium predicts greater mortality. | Kiely DK, Marcantonio ER, Inouye SK, Shaffer ML, Bergmann MA, Yang FM, Fearing MA, Jones RN | Journal of the American Geriatrics Society | 2009 |
Aged, Aged, 80 and over, Cohort Studies, Delirium, etiology, Female, Homes for the Aged, Hospitalization, Humans, Male, Nursing Homes |
| Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients. | Pandharipande PP, Morandi A, Adams JR, Girard TD, Thompson JL, Shintani AK, Ely EW | Intensive care medicine | 2009 |
Aged, Amino Acid Transport System L, blood, Analysis of Variance, Critical Illness, Delirium, blood, Disease Progression, Female, Humans, Logistic Models, Male, Markov Chains, Middle Aged, Phenylalanine, blood, Pilot Projects, Predictive Value of Tests, Regression Analysis, Risk Assessment, Risk Factors, Severity of Illness Index, Tennessee, Time Factors, Tryptophan, blood, Tyrosine, blood |
| Markers of cerebral damage during delirium in elderly patients with hip fracture. | van Munster BC, Korse CM, de Rooij SE, Bonfrer JM, Zwinderman AH, Korevaar JC | BMC neurology | 2009 |
Aged, Aged, 80 and over, Biological Markers, blood, Brain Injuries, blood, Delirium, blood, Female, Hip Fractures, blood, Humans, Male, Nerve Growth Factors, blood, Phosphopyruvate Hydratase, blood, Retrospective Studies, S100 Calcium Binding Protein beta Subunit, S100 Proteins, blood |
| Implementation of a delirium assessment tool in the ICU can influence haloperidol use. | van den Boogaard M, Pickkers P, van der Hoeven H, Roodbol G, van Achterberg T, Schoonhoven L | Critical care (London, England) | 2009 |
Adult, Aged, Antipsychotic Agents, administration & dosage, Delirium, diagnosis, Female, Guideline Adherence, Haloperidol, administration & dosage, Humans, Inservice Training, Intensive Care Units, Leadership, Male, Middle Aged, Reminder Systems, Reproducibility of Results |
| The association between delirium and the apolipoprotein E epsilon 4 allele: new study results and a meta-analysis. | van Munster BC, Korevaar JC, Zwinderman AH, Leeflang MM, de Rooij SE | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2009 |
Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Alleles, Apolipoprotein E4, genetics, Cognition Disorders, complications, Delirium, complications, Female, Genotype, Geriatric Assessment, Humans, Male, Patients, psychology |
| Telephone interview for cognitive status: Creating a crosswalk with the Mini-Mental State Examination. | Fong TG, Fearing MA, Jones RN, Shi P, Marcantonio ER, Rudolph JL, Yang FM, Kiely DK, Inouye SK | Alzheimer's & dementia : the journal of the Alzheimer's Association | 2009 |
Aged, Aged, 80 and over, Alzheimer Disease, diagnosis, Cognition Disorders, diagnosis, Disability Evaluation, Female, Geriatric Assessment, methods, Health Status, Humans, Interviews as Topic, methods, Male, Mass Screening, methods, Models, Statistical, Neuropsychological Tests, Predictive Value of Tests, Psychiatric Status Rating Scales, Remote Consultation, methods, Reproducibility of Results, Sensitivity and Specificity |
| The role of genetics in delirium in the elderly patient. | van Munster BC, de Rooij SE, Korevaar JC | Dementia and geriatric cognitive disorders | 2009 |
Aged, psychology, Delirium, genetics, Genotype, Humans, Research |
| The evaluation of delirium post-stroke. | Mc Manus J, Pathansali R, Hassan H, Ouldred E, Cooper D, Stewart R, Macdonald A, Jackson S | International journal of geriatric psychiatry | 2009 |
Adult, Aged, Aged, 80 and over, Delirium, diagnosis, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, standards, Risk Assessment, Sensitivity and Specificity, Stroke, psychology, Young Adult |
| Assessment of the risk of postoperative delirium in elderly patients using E-PASS and the NEECHAM Confusion Scale. | Hattori H, Kamiya J, Shimada H, Akiyama H, Yasui A, Kuroiwa K, Oda K, Ando M, Kawamura T, Harada A, Kitagawa Y, Fukata S | International journal of geriatric psychiatry | 2009 |
Activities of Daily Living, Aged, Aged, 80 and over, Delirium, diagnosis, Female, Humans, Male, Postoperative Complications, diagnosis, Psychiatric Status Rating Scales, Quality of Life, Risk Factors |
| Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study). | Shehabi Y, Grant P, Wolfenden H, Hammond N, Bass F, Campbell M, Chen J | Anesthesiology | 2009 |
Adrenergic alpha-Agonists, adverse effects, Aged, Analgesics, Opioid, adverse effects, Delirium, chemically induced, Dexmedetomidine, adverse effects, Double-Blind Method, Female, Humans, Hypnotics and Sedatives, adverse effects, Intensive Care Units, Intra-Aortic Balloon Pumping, Male, Morphine, adverse effects, Pain, Postoperative, drug therapy, Postoperative Care, Propofol, administration & dosage |
| Non-pharmacological interventions in the prevention of delirium. | Tabet N, Howard R | Age and ageing | 2009 |
Aged, Aged, 80 and over, Caregivers, education, Clinical Trials as Topic, Delirium, prevention & control, Humans, Randomized Controlled Trials as Topic, Risk Factors |
| Benzodiazepines for delirium. | Lonergan E, Luxenberg J, Areosa Sastre A | The Cochrane database of systematic reviews | 2009 |
Benzodiazepines, therapeutic use, Delirium, drug therapy, Dexmedetomidine, therapeutic use, Humans, Lorazepam, therapeutic use |
| Delirium accelerates cognitive decline in Alzheimer disease. | Fong TG, Jones RN, Shi P, Marcantonio ER, Yap L, Rudolph JL, Yang FM, Kiely DK, Inouye SK | Neurology | 2009 |
Age Distribution, Aged, Aged, 80 and over, Alzheimer Disease, epidemiology, Cognition Disorders, diagnosis, Cohort Studies, Comorbidity, Delirium, epidemiology, Disease Progression, Female, Humans, Incidence, Male, Massachusetts, Neuropsychological Tests, Prospective Studies, Registries, Sex Characteristics, Time Factors |
| Cytokines and IGF-I in delirious and non-delirious acutely ill older medical inpatients. | Adamis D, Lunn M, Martin FC, Treloar A, Gregson N, Hamilton G, Macdonald AJ | Age and ageing | 2009 |
APACHE, Acute Disease, Age Factors, Aged, Aged, 80 and over, Apolipoprotein E4, genetics, Biological Markers, blood, Cognition, Cytokines, blood, Delirium, blood, Female, Humans, Insulin-Like Growth Factor I, analysis, Interferon-gamma, blood, Interleukin 1 Receptor Antagonist Protein, blood, Longitudinal Studies, Male, Prospective Studies |
| Predicting the onset of delirium in the post-operative patient. | Noimark D | Age and ageing | 2009 |
Aged, Delirium, complications, Forecasting, Frail Elderly, Geriatric Assessment, Humans, Postoperative Complications, etiology, Preoperative Care, Risk Assessment, Risk Factors, Surgical Procedures, Operative, adverse effects |
| Measures of executive function and depression identify patients at risk for postoperative delirium. | Greene NH, Attix DK, Weldon BC, Smith PJ, McDonagh DL, Monk TG | Anesthesiology | 2009 |
Aged, Cognition, physiology, Cognition Disorders, complications, Cohort Studies, Delirium, diagnosis, Depression, complications, Female, Humans, Incidence, Male, Middle Aged, Neuropsychological Tests, Postoperative Complications, diagnosis, Predictive Value of Tests, Preoperative Care, Prospective Studies, Risk Factors, Surgical Procedures, Elective, adverse effects, Treatment Outcome |
| Executive function and depression as independent risk factors for postoperative delirium. | Smith PJ, Attix DK, Weldon BC, Greene NH, Monk TG | Anesthesiology | 2009 |
Adolescent, Adult, Aged, Aged, 80 and over, Cognition, physiology, Cognition Disorders, complications, Delirium, etiology, Depression, complications, Female, Humans, Male, Middle Aged, Postoperative Complications, Predictive Value of Tests, Retrospective Studies, Risk Factors, Surgical Procedures, Elective, adverse effects, Young Adult |
| Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery--a randomized controlled trial. | Gamberini M, Bolliger D, Lurati Buse GA, Burkhart CS, Grapow M, Gagneux A, Filipovic M, Seeberger MD, Pargger H, Siegemund M, Carrel T, Seiler WO, Berres M, Strebel SP, Monsch AU, Steiner LA | Critical care medicine | 2009 |
Administration, Oral, Age Factors, Aged, Aged, 80 and over, Cardiac Surgical Procedures, adverse effects, Cardiopulmonary Bypass, adverse effects, Delirium, epidemiology, Double-Blind Method, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Incidence, Male, Mental Status Schedule, Neuroprotective Agents, administration & dosage, Phenylcarbamates, administration & dosage, Postoperative Complications, prevention & control, Preoperative Care, methods, Probability, Reference Values, Risk Assessment, Surgical Procedures, Elective, adverse effects, Treatment Outcome |
| Comparison of delirium assessment tools in a mixed intensive care unit. | van Eijk MM, van Marum RJ, Klijn IA, de Wit N, Kesecioglu J, Slooter AJ | Critical care medicine | 2009 |
Aged, Delirium, diagnosis, Diagnostic Techniques, Neurological, Female, Humans, Intensive Care Units, Male, Middle Aged, Prospective Studies |
| The impact of delirium on clinical outcomes in mechanically ventilated surgical and trauma patients. | Lat I, McMillian W, Taylor S, Janzen JM, Papadopoulos S, Korth L, Ehtisham A, Nold J, Agarwal S, Azocar R, Burke P | Critical care medicine | 2009 |
Adult, Aged, Critical Illness, Delirium, epidemiology, Female, Humans, Incidence, Male, Middle Aged, Postoperative Complications, epidemiology, Prospective Studies, Respiration, Artificial, Risk Factors, Wounds and Injuries, complications |