What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Atherosclerosis is associated with delirium after coronary artery bypass graft surgery. | Rudolph JL, Babikian VL, Birjiniuk V, Crittenden MD, Treanor PR, Pochay VE, Khuri SF, Marcantonio ER | Journal of the American Geriatrics Society | 2005 |
Aged, Arteriosclerosis, classification, Boston, epidemiology, Comorbidity, Coronary Artery Bypass, adverse effects, Delirium, etiology, Hospitals, Veterans, Humans, Incidence, Length of Stay, Male, Middle Aged, Postoperative Complications, Predictive Value of Tests, Risk Factors, Severity of Illness Index |
| Altered mental status: cause determines treatment. | Washburn LA | JAAPA : official journal of the American Academy of Physician Assistants | 2005 |
Delirium, diagnosis, Humans |
| A multifactorial intervention to reduce prevalence of delirium and shorten hospital length of stay. | Naughton BJ, Saltzman S, Ramadan F, Chadha N, Priore R, Mylotte JM | Journal of the American Geriatrics Society | 2005 |
Aged, Aged, 80 and over, Cognition Disorders, Delirium, complications, Emergency Service, Hospital, Female, Health Services for the Aged, Humans, Intervention Studies, Length of Stay, Male, Patient Admission, Prevalence, Psychotropic Drugs, therapeutic use |
| Fast, systematic, and continuous delirium assessment in hospitalized patients: the nursing delirium screening scale. | Gaudreau JD, Gagnon P, Harel F, Tremblay A, Roy MA | Journal of pain and symptom management | 2005 |
Adolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, Delirium, classification, Female, Hospitalization, Humans, Male, Mass Screening, methods, Mental Status Schedule, Middle Aged, Nursing Diagnosis, methods, Psychiatric Status Rating Scales, Psychometrics, methods, Reproducibility of Results, Sensitivity and Specificity, Severity of Illness Index, Single-Blind Method |
| Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. | Kalisvaart KJ, de Jonghe JF, Bogaards MJ, Vreeswijk R, Egberts TC, Burger BJ, Eikelenboom P, van Gool WA | Journal of the American Geriatrics Society | 2005 |
Aged, Aged, 80 and over, Antipsychotic Agents, adverse effects, Delirium, prevention & control, Double-Blind Method, Female, Haloperidol, adverse effects, Hip Fractures, surgery, Humans, Male, Mental Status Schedule, Osteoarthritis, Hip, surgery, Outcome Assessment (Health Care), Postoperative Complications, prevention & control, Psychiatric Status Rating Scales, Risk Factors, Treatment Outcome |
| A multifactorial intervention program reduces the duration of delirium, length of hospitalization, and mortality in delirious patients. | Lundström M, Edlund A, Karlsson S, Brännström B, Bucht G, Gustafson Y | Journal of the American Geriatrics Society | 2005 |
Aged, Analysis of Variance, Delirium, epidemiology, Female, Geriatric Nursing, education, Geriatrics, education, Hospital Mortality, Humans, Inservice Training, Intervention Studies, Length of Stay, Logistic Models, Male, Nursing Care, organization & administration, Patient Care Management, organization & administration, Prevalence, Professional-Patient Relations, Prospective Studies, Sweden, epidemiology |
| Delirium-O-Meter: a nurses' rating scale for monitoring delirium severity in geriatric patients. | de Jonghe JF, Kalisvaart KJ, Timmers JF, Kat MG, Jackson JC | International journal of geriatric psychiatry | 2005 |
Aged, Aged, 80 and over, Delirium, diagnosis, Dementia, psychology, Epidemiologic Methods, Female, Geriatric Assessment, methods, Humans, Male, Mental Disorders, psychology, Observer Variation, Psychiatric Status Rating Scales |
| Delirium as detected by the CAM-ICU predicts restraint use among mechanically ventilated medical patients. | Micek ST, Anand NJ, Laible BR, Shannon WD, Kollef MH | Critical care medicine | 2005 |
Adult, Aged, Analgesics, Opioid, adverse effects, Delirium, diagnosis, Female, Fentanyl, adverse effects, Hospital Mortality, Humans, Hypnotics and Sedatives, adverse effects, Incidence, Length of Stay, Male, Midazolam, adverse effects, Middle Aged, Missouri, epidemiology, Prospective Studies, Psychiatric Status Rating Scales, Respiration, Artificial, Restraint, Physical, adverse effects |
| Delirium is associated with poor rehabilitation outcome in elderly patients treated for femoral neck fractures. | Olofsson B, Lundström M, Borssén B, Nyberg L, Gustafson Y | Scandinavian journal of caring sciences | 2005 |
Activities of Daily Living, Aged, Aged, 80 and over, Delirium, epidemiology, Dementia, complications, Depression, complications, Female, Femoral Neck Fractures, complications, Follow-Up Studies, Fracture Fixation, Internal, methods, Geriatric Assessment, Health Services Needs and Demand, Hospitals, University, Humans, Length of Stay, statistics & numerical data, Male, Mental Health, Postoperative Care, methods, Quality of Health Care, Questionnaires, Risk Factors, Sweden, epidemiology, Treatment Outcome |
| 'Fishing with the dead'--recall of memories from the ICU. | Magarey JM, McCutcheon HH | Intensive & critical care nursing : the official journal of the British Association of Critical Care Nurses | 2005 |
Adult, Aged, Aged, 80 and over, Attitude to Health, Australia, Confusion, psychology, Conscious Sedation, adverse effects, Delusions, psychology, Dreams, psychology, Fear, Female, Hallucinations, psychology, Hospitals, Public, Hospitals, Teaching, Humans, Intensive Care, psychology, Length of Stay, Male, Mental Recall, Middle Aged, Nursing Methodology Research, Qualitative Research, Questionnaires, Retrospective Studies |
| Aripiprazole in the treatment of delirium. | Alao AO, Soderberg M, Pohl EL, Koss M | International journal of psychiatry in medicine | 2005 |
Adult, Aged, Antipsychotic Agents, therapeutic use, Cognition Disorders, complications, Delirium, complications, Female, Humans, Male, Neuropsychological Tests, Piperazines, therapeutic use, Quinolones, therapeutic use |
| Risk factors for delirium in acutely admitted elderly patients: a prospective cohort study. | Korevaar JC, van Munster BC, de Rooij SE | BMC geriatrics | 2005 |
Acute Disease, Aged, Aged, 80 and over, Delirium, diagnosis, Female, Humans, Male, Patient Admission, Prospective Studies, Risk Factors |
| After adoption: sustaining the innovation. A case study of disseminating the hospital elder life program. | Bradley EH, Webster TR, Baker D, Schlesinger M, Inouye SK | Journal of the American Geriatrics Society | 2005 |
Aged, Data Collection, Health Services for the Aged, economics, Hospitalization, Humans, Interviews as Topic, Leadership, Longitudinal Studies, United States |
| Consequences of preventing delirium in hospitalized older adults on nursing home costs. | Leslie DL, Zhang Y, Bogardus ST, Holford TR, Leo-Summers LS, Inouye SK | Journal of the American Geriatrics Society | 2005 |
Activities of Daily Living, Aged, Case-Control Studies, Costs and Cost Analysis, statistics & numerical data, Dementia, economics, Female, Geriatrics, economics, Hospitalization, Humans, Long-Term Care, economics, Longitudinal Studies, Male, Nursing Homes, economics, Randomized Controlled Trials as Topic, Regression Analysis |
| A model for management of delirious postacute care patients. | Bergmann MA, Murphy KM, Kiely DK, Jones RN, Marcantonio ER | Journal of the American Geriatrics Society | 2005 |
Aged, Delirium, etiology, Humans, Mental Status Schedule, Nursing Assessment, Nursing Diagnosis, Nursing Records, Patient Admission, Patient Care Planning, Patient Discharge, Referral and Consultation, Rehabilitation Centers, Rehabilitation Nursing, Self Care, Skilled Nursing Facilities |
| When patients lack capacity: the roles that patients with terminal diagnoses would choose for their physicians and loved ones in making medical decisions. | Nolan MT, Hughes M, Narendra DP, Sood JR, Terry PB, Astrow AB, Kub J, Thompson RE, Sulmasy DP | Journal of pain and symptom management | 2005 |
Advance Directives, Aged, Choice Behavior, Decision Making, Family, Female, Humans, Male, Mental Competency, Middle Aged, Patient Satisfaction, Physicians, Terminal Care, psychology |
| Premature death associated with delirium at 1-year follow-up. | Leslie DL, Zhang Y, Holford TR, Bogardus ST, Leo-Summers LS, Inouye SK | Archives of internal medicine | 2005 |
Aged, Aged, 80 and over, Analysis of Variance, Case-Control Studies, Cause of Death, Connecticut, epidemiology, Delirium, complications, Female, Follow-Up Studies, Humans, Male, Regression Analysis, Risk Factors, Time Factors |
| Delirium in Parkinson's disease patients. a five-year follow-up study. | Serrano-Dueñas M, Bleda MJ | Parkinsonism & related disorders | 2005 |
Aged, Analysis of Variance, Antiparkinson Agents, therapeutic use, Case-Control Studies, Delirium, etiology, Dementia, complications, Female, Follow-Up Studies, Humans, Levodopa, therapeutic use, Male, Neuropsychological Tests, Parkinson Disease, complications, Prospective Studies, Psychiatric Status Rating Scales, Regression Analysis, Risk Factors, Survival Analysis |
| Recovery room delirium predicts postoperative delirium after hip-fracture repair. | Sharma PT, Sieber FE, Zakriya KJ, Pauldine RW, Gerold KB, Hang J, Smith TH | Anesthesia and analgesia | 2005 |
Aged, Aged, 80 and over, Delirium, etiology, Female, Hip Fractures, urine, Humans, Male, Middle Aged, Postoperative Complications, etiology, Recovery Room |
| Capacity, consent, and selection bias in a study of delirium. | Adamis D, Martin FC, Treloar A, Macdonald AJ | Journal of medical ethics | 2005 |
Aged, Delirium, psychology, Female, Humans, Informed Consent, Male, Mental Competency, Patient Selection, Research Design, Selection Bias |
| Hospital at home: feasibility and outcomes of a program to provide hospital-level care at home for acutely ill older patients. | Leff B, Burton L, Mader SL, Naughton B, Burl J, Inouye SK, Greenough WB, Guido S, Langston C, Frick KD, Steinwachs D, Burton JR | Annals of internal medicine | 2005 |
Acute Disease, therapy, Aged, Aged, 80 and over, Cellulitis, complications, Community-Acquired Infections, complications, Feasibility Studies, Female, Health Services for the Aged, economics, Home Care Services, Hospital-Based, economics, Hospitalization, economics, Humans, Length of Stay, Lung Diseases, Obstructive, complications, Male, Outcome Assessment (Health Care), Pneumonia, complications, Program Evaluation, Prospective Studies, Selection Bias, United States |
| Prediction of delirium in fractured neck of femur as part of routine preoperative nursing care. | Freter SH, George J, Dunbar MJ, Morrison M, Macknight C, Rockwood K | Age and ageing | 2005 |
Aged, Aged, 80 and over, Cognition Disorders, complications, Delirium, etiology, Female, Femoral Neck Fractures, complications, Geriatric Assessment, Humans, Male, Nursing Assessment, Predictive Value of Tests, Preoperative Care, Risk Factors |
| Are preoperative depressive symptoms associated with postoperative delirium in geriatric surgical patients? | Leung JM, Sands LP, Mullen EA, Wang Y, Vaurio L | The journals of gerontology. Series A, Biological sciences and medical sciences | 2005 |
Aged, Aged, 80 and over, Delirium, epidemiology, Depression, complications, Female, Humans, Male, Multivariate Analysis, Postoperative Complications, epidemiology, Preoperative Care, Prognosis |
| Donepezil in the prevention and treatment of post-surgical delirium. | Liptzin B, Laki A, Garb JL, Fingeroth R, Krushell R | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2005 |
Aged, Aged, 80 and over, Cholinesterase Inhibitors, therapeutic use, Delirium, drug therapy, Double-Blind Method, Female, Humans, Indans, therapeutic use, Male, Middle Aged, Pilot Projects, Piperidines, therapeutic use, Postoperative Complications |
| Predictors and outcomes of delirium. | Minden SL, Carbone LA, Barsky A, Borus JF, Fife A, Fricchione GL, Orav EJ | General hospital psychiatry | 2005 |
Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal, surgery, Delirium, diagnosis, Female, Humans, Male, Middle Aged, Postoperative Period, Thoracic Surgical Procedures, psychology, Treatment Outcome, United States, epidemiology |
| Cognitively impaired older adults: from hospital to home. | Naylor MD, Stephens C, Bowles KH, Bixby MB | The American journal of nursing | 2005 |
Aftercare, Aged, Aged, 80 and over, Alzheimer Disease, epidemiology, Caregivers, Continuity of Patient Care, Female, Geriatric Nursing, Health Services for the Aged, utilization, Home Care Services, Humans, Male, Needs Assessment, Patient Discharge, Pennsylvania, epidemiology |
| Incidence, clinical features and subtypes of delirium in elderly patients treated for hip fractures. | Santana Santos F, Wahlund LO, Varli F, Tadeu Velasco I, Eriksdotter Jonhagen M | Dementia and geriatric cognitive disorders | 2005 |
Age Factors, Aged, Aged, 80 and over, Delirium, epidemiology, Female, Fracture Fixation, Internal, adverse effects, Hip Fractures, complications, Humans, Hypnotics and Sedatives, adverse effects, Male, Midazolam, adverse effects, Middle Aged, Nursing Homes, Postoperative Complications, epidemiology, Psychiatric Status Rating Scales, Risk Factors, Sex Factors |
| Postoperative delirium in elderly patients after major abdominal surgery. | Olin K, Eriksdotter-Jönhagen M, Jansson A, Herrington MK, Kristiansson M, Permert J | The British journal of surgery | 2005 |
Abdomen, surgery, Aged, Cognition Disorders, diagnosis, Delirium, etiology, Female, Humans, Male, Postoperative Complications, etiology, Prospective Studies |
| Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. | Thomason JW, Shintani A, Peterson JF, Pun BT, Jackson JC, Ely EW | Critical care (London, England) | 2005 |
Cohort Studies, Delirium, epidemiology, Female, Hospital Mortality, Humans, Intensive Care, statistics & numerical data, Intensive Care Units, statistics & numerical data, Length of Stay, statistics & numerical data, Male, Middle Aged, Outcome and Process Assessment (Health Care), Proportional Hazards Models, Prospective Studies, Risk Factors, Tennessee, epidemiology |
| Efficacy of a comprehensive geriatric intervention in older patients hospitalized for hip fracture: a randomized, controlled trial. | Vidán M, Serra JA, Moreno C, Riquelme G, Ortiz J | Journal of the American Geriatrics Society | 2005 |
Aged, Female, Health Services for the Aged, Hip Fractures, complications, Hospitalization, Humans, Length of Stay, Male, Patient Care Team, Treatment Outcome |
| Enzymes of drug metabolism during delirium. | White S, Calver BL, Newsway V, Wade R, Patel S, Bayer A, O'Mahony MS | Age and ageing | 2005 |
Acetylcholinesterase, blood, Aged, Aged, 80 and over, Butyrylcholinesterase, blood, C-Reactive Protein, analysis, Carboxylic Ester Hydrolases, blood, Case-Control Studies, Delirium, blood, Esterases, blood, Female, Humans, Male, Pharmaceutical Preparations, metabolism, Pseudocholinesterase, blood, Serum Albumin, analysis |
| Plasma insulin growth factor-1 and incident delirium in older people. | Wilson K, Broadhurst C, Diver M, Jackson M, Mottram P | International journal of geriatric psychiatry | 2005 |
APACHE, Aged, Delirium, blood, Humans, Incidence, Insulin-Like Growth Factor I, analysis, Mental Disorders, blood, Odds Ratio, Prospective Studies, Risk Factors |
| A chart-based method for identification of delirium: validation compared with interviewer ratings using the confusion assessment method. | Inouye SK, Leo-Summers L, Zhang Y, Bogardus ST, Leslie DL, Agostini JV | Journal of the American Geriatrics Society | 2005 |
Aged, Aged, 80 and over, Delirium, diagnosis, Female, Humans, Interview, Psychological, Male, Medical Records, Prospective Studies, Psychological Tests, Reproducibility of Results, Sensitivity and Specificity, Severity of Illness Index |
| The performance of the Clock Drawing Test in elderly medical inpatients: does it have utility in the identification of delirium? | Adamis D, Morrison C, Treloar A, Macdonald AJ, Martin FC | Journal of geriatric psychiatry and neurology | 2005 |
Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Delirium, diagnosis, Female, Humans, Male, Neuropsychological Tests, Prospective Studies, Severity of Illness Index |
| Psychometric properties of the Flemish translation of the NEECHAM Confusion Scale. | Milisen K, Foreman MD, Hendrickx A, Godderis J, Abraham IL, Broos PL, De Geest S | BMC psychiatry | 2005 |
Aged, 80 and over, Belgium, Confusion, diagnosis, Data Collection, methods, Delirium, diagnosis, Female, Geriatric Assessment, Hip Fractures, complications, Humans, Male, Nursing Diagnosis, methods, Predictive Value of Tests, Principal Component Analysis, Psychiatric Status Rating Scales, statistics & numerical data, Psychometrics, Reproducibility of Results, Sensitivity and Specificity, Severity of Illness Index, Translations |
| Use of serial Mini-Mental State Examinations to diagnose and monitor delirium in elderly hospital patients. | O'Keeffe ST, Mulkerrin EC, Nayeem K, Varughese M, Pillay I | Journal of the American Geriatrics Society | 2005 |
Aged, psychology, Delirium, diagnosis, Geriatric Assessment, methods, Hospitalization, Humans, Mental Status Schedule, Prospective Studies, Sensitivity and Specificity |
| Dissemination of the hospital elder life program: implementation, adaptation, and successes. | Inouye SK, Baker DI, Fugal P, Bradley EH, | Journal of the American Geriatrics Society | 2006 |
Aged, Cross-Sectional Studies, Delirium, prevention & control, Diffusion of Innovation, Health Services for the Aged, Hospitalization, Humans, Outcome Assessment (Health Care), Program Development, Program Evaluation |
| Here's HELP to prevent delirium in the hospital. | Sandhaus S, Harrell F, Valenti D | Nursing | 2006 |
Activities of Daily Living, Aged, Communication, Delirium, etiology, Food Service, Hospital, Geriatric Assessment, Geriatric Nursing, organization & administration, Health Services Needs and Demand, Humans, Inpatients, Models, Nursing, Nurse’s Role, Nursing Assessment, Nursing Evaluation Research, Patient Care Planning, Recreation, Relaxation Therapy, Risk Factors, Spirituality, Volunteers, education |
| Clinical characteristics and risk factors of delirium in demented and not demented elderly medical inpatients. | Margiotta A, Bianchetti A, Ranieri P, Trabucchi M | The journal of nutrition, health & aging | 2006 |
APACHE, Aged, Aged, 80 and over, Cognition, physiology, Comorbidity, Cross-Sectional Studies, Delirium, epidemiology, Dementia, epidemiology, Female, Geriatric Assessment, Hospitalization, Humans, Length of Stay, Male, Psychiatric Status Rating Scales, Psychomotor Disorders, epidemiology, Risk Factors |
| An 18-month prospective cohort study of functional outcome of delirium in elderly patients: activities of daily living. | Vida S, Galbaud du Fort G, Kakuma R, Arsenault L, Platt RW, Wolfson CM | International psychogeriatrics / IPA | 2006 |
Activities of Daily Living, classification, Aged, Aged, 80 and over, Alzheimer Disease, diagnosis, Cohort Studies, Delirium, diagnosis, Emergency Service, Hospital, Female, Humans, Hypertension, diagnosis, Male, Outcome Assessment (Health Care), Parkinson Disease, diagnosis, Prognosis, Prospective Studies, Quebec, Sex Factors, Stroke, diagnosis |
| Delirium in hospitalized older patients with cancer. | Bond SM, Neelon VJ, Belyea MJ | Oncology nursing forum | 2006 |
APACHE, Acute Disease, Aged, Aged, 80 and over, Delirium, diagnosis, Female, Hospitalization, Humans, Male, Neoplasms, epidemiology, Oncology Nursing, Patient Discharge, Prevalence, Risk Factors |
| Dysgraphia in elderly delirious medical inpatients. | Adamis D, Reich S, Treloar A, Macdonald AJ, Martin FC | Aging clinical and experimental research | 2006 |
APACHE, Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Agraphia, etiology, Cognition Disorders, complications, Delirium, complications, Female, Geriatric Assessment, methods, Humans, Incidence, Inpatients, Intelligence Tests, Male, Prospective Studies, Sensitivity and Specificity |
| Detection of delirium by bedside nurses using the confusion assessment method. | Lemiengre J, Nelis T, Joosten E, Braes T, Foreman M, Gastmans C, Milisen K | Journal of the American Geriatrics Society | 2006 |
Aged, 80 and over, Algorithms, Confusion, diagnosis, Delirium, diagnosis, Female, Geriatric Assessment, Humans, Male, Nursing Assessment, Prospective Studies, Psychiatric Status Rating Scales, Reproducibility of Results, Sensitivity and Specificity |
| Reliability of a structured assessment for nonclinicians to detect delirium among new admissions to postacute care. | Simon SE, Bergmann MA, Jones RN, Murphy KM, Orav EJ, Marcantonio ER | Journal of the American Medical Directors Association | 2006 |
Aged, Aged, 80 and over, Boston, epidemiology, Delirium, diagnosis, Female, Geriatric Assessment, methods, Humans, Interview, Psychological, methods, Male, Mental Status Schedule, standards, Nursing Assessment, methods, Observer Variation, Patient Admission, Prevalence, Prospective Studies, Psychiatric Status Rating Scales, Sensitivity and Specificity, Severity of Illness Index, Single-Blind Method, Skilled Nursing Facilities, Subacute Care |
| Falls in the general hospital: association with delirium, advanced age, and specific surgical procedures. | Lakatos BE, Capasso V, Mitchell MT, Kilroy SM, Lussier-Cushing M, Sumner L, Repper-Delisi J, Kelleher EP, Delisle LA, Cruz C, Stern TA | Psychosomatics | 2009 |
Accidental Falls, prevention & control, Age Factors, Aged, Aged, 80 and over, Cross-Sectional Studies, Delirium, diagnosis, Diagnosis, Differential, Female, Hospitals, General, statistics & numerical data, Humans, Injury Severity Score, Male, Massachusetts, Middle Aged, Postoperative Complications, diagnosis, Recurrence, prevention & control, Retrospective Studies, Risk Factors, Wounds and Injuries, epidemiology |
| Phenomenological subtypes of delirium in older persons: patterns, prevalence, and prognosis. | Yang FM, Marcantonio ER, Inouye SK, Kiely DK, Rudolph JL, Fearing MA, Jones RN | Psychosomatics | 2009 |
Aged, Aged, 80 and over, Comorbidity, Cross-Sectional Studies, Delirium, classification, Female, Humans, Incidence, Longitudinal Studies, Male, Motor Activity, Neuropsychological Tests, Prognosis, Psychomotor Disorders, classification, Survival Rate |
| Use of antipsychotic medications for the management of delirium: an audit of current practice in the acute care setting. | Tropea J, Slee J, Holmes AC, Gorelik A, Brand CA | International psychogeriatrics / IPA | 2009 |
Aged, Aged, 80 and over, Antipsychotic Agents, therapeutic use, Delirium, drug therapy, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Utilization, statistics & numerical data, Episode of Care, Female, Guideline Adherence, statistics & numerical data, Hospitalization, statistics & numerical data, Humans, Male, Medical Audit, Quality Assurance, Health Care, statistics & numerical data, Utilization Review, statistics & numerical data, Victoria |
| In harm's way: Moving the older trauma patient toward a better outcome. | Campbell JW, Degolia PA, Fallon WF, Rader EL | Geriatrics | 2009 |
Aged, Burns, complications, Delirium, complications, Frail Elderly, Geriatrics, Humans, Nutrition Assessment, Pain, complications, Patient Discharge, Wounds and Injuries, prevention & control |
| Predictors of mortality in patients with delirium tremens. | Khan A, Levy P, DeHorn S, Miller W, Compton S | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine | 2008 |
Alcohol Withdrawal Delirium, drug therapy, Benzodiazepines, therapeutic use, Case-Control Studies, Chi-Square Distribution, Comorbidity, Emergency Service, Hospital, Female, Hospitalization, Humans, Logistic Models, Male, Odds Ratio, Restraint, Physical, Risk Factors |
| Maximizing clinical research participation in vulnerable older persons: identification of barriers and motivators. | Marcantonio ER, Aneja J, Jones RN, Alsop DC, Fong TG, Crosby GJ, Culley DJ, Cupples LA, Inouye SK | Journal of the American Geriatrics Society | 2008 |
Aged, Aged, 80 and over, Biomedical Research, Female, Health Surveys, Humans, Interview, Psychological, Magnetic Resonance Imaging, Male, Motivation, Neuropsychological Tests, Patient Acceptance of Health Care, psychology, Patient Selection, Phlebotomy, psychology, Spinal Puncture, psychology |
| Risk factors for hospitalization among community-dwelling primary care older patients: development and validation of a predictive model. | Inouye SK, Zhang Y, Jones RN, Shi P, Cupples LA, Calderon HN, Marcantonio ER | Medical care | 2008 |
Aged, Aged, 80 and over, Emergency Service, Hospital, Female, Forecasting, Geriatrics, Hospitalization, trends, Humans, Male, Massachusetts, Models, Theoretical, Prospective Studies, Referral and Consultation, trends, Risk Factors |
| The Confusion Assessment Method: a systematic review of current usage. | Wei LA, Fearing MA, Sternberg EJ, Inouye SK | Journal of the American Geriatrics Society | 2008 |
Aged, Algorithms, Confusion, diagnosis, Delirium, diagnosis, Emergency Service, Hospital, Humans, Institutionalization, Intensive Care Units, Neuropsychological Tests, statistics & numerical data, Psychometrics, statistics & numerical data, Reproducibility of Results |
| Improving sedative-hypnotic prescribing in older hospitalized patients: provider-perceived benefits and barriers of a computer-based reminder. | Agostini JV, Concato J, Inouye SK | Journal of general internal medicine | 2008 |
Accidental Falls, statistics & numerical data, Aged, Aged, 80 and over, Boston, Delirium, chemically induced, Drug Therapy, Computer-Assisted, Drug Utilization, Female, Forecasting, Geriatric Assessment, Health Care Surveys, Hospitalization, Hospitals, University, Humans, Hypnotics and Sedatives, adverse effects, Male, Medication Errors, prevention & control, Point-of-Care Systems, Quality of Health Care, Reminder Systems, Risk Assessment |
| Participation in activity and risk for incident delirium. | Yang FM, Inouye SK, Fearing MA, Kiely DK, Marcantonio ER, Jones RN | Journal of the American Geriatrics Society | 2008 |
Activities of Daily Living, Aged, Aged, 80 and over, Cohort Studies, Delirium, diagnosis, Educational Status, Exercise, Female, Humans, Leisure Activities, Logistic Models, Male, Mathematical Computing, Neuropsychological Tests, statistics & numerical data, Prospective Studies, Psychometrics, statistics & numerical data, Risk Factors, Social Behavior |
| Statins and postoperative delirium. | Marcantonio ER | CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne | 2008 |
Atherosclerosis, epidemiology, Causality, Delirium, epidemiology, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, adverse effects, Pharmacoepidemiology, methods, Postoperative Complications, epidemiology, Risk Factors |
| Time-course of cytokines during delirium in elderly patients with hip fractures. | van Munster BC, Korevaar JC, Zwinderman AH, Levi M, Wiersinga WJ, De Rooij SE | Journal of the American Geriatrics Society | 2008 |
Aged, Aged, 80 and over, Arthroplasty, Replacement, Hip, Cohort Studies, Cytokines, blood, Delirium, immunology, Female, Femoral Neck Fractures, immunology, Fracture Fixation, Internal, Hip Fractures, immunology, Humans, Interleukin-6, blood, Interleukin-8, blood, Male, Netherlands, Patient Admission, Postoperative Complications, immunology, Prospective Studies, Psychomotor Agitation, immunology, Statistics as Topic, Time Factors |
| Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence. | Hshieh TT, Fong TG, Marcantonio ER, Inouye SK | The journals of gerontology. Series A, Biological sciences and medical sciences | 2008 |
Acetylcholine, deficiency, Brain, metabolism, Delirium, etiology, Dementia, physiopathology, Humans, Neurotransmitter Agents, physiology, Receptors, Neurotransmitter, physiology |
| Prevalence, detection and treatment of delirium in terminal cancer inpatients: a prospective survey. | Fang CK, Chen HW, Liu SI, Lin CJ, Tsai LY, Lai YL | Japanese journal of clinical oncology | 2008 |
Adult, Aged, Aged, 80 and over, Critical Illness, therapy, Delirium, diagnosis, Diagnosis, Differential, Female, Health Surveys, Hospice Care, statistics & numerical data, Humans, Inpatients, psychology, Male, Middle Aged, Neoplasms, therapy, Palliative Care, statistics & numerical data, Prevalence, Prospective Studies, Survival Rate, Taiwan, epidemiology |
| Hazards of hospitalization: residence prior to admission predicts outcomes. | Friedman SM, Mendelson DA, Bingham KW, McCann RM | The Gerontologist | 2008 |
Accidental Falls, statistics & numerical data, Activities of Daily Living, Aged, Aged, 80 and over, Assisted Living Facilities, Delirium, Depression, Female, Geriatric Assessment, statistics & numerical data, Hospitalization, statistics & numerical data, Humans, Logistic Models, Male, New York, Nursing Homes, Pressure Ulcer, Prognosis, Prospective Studies, Risk |
| Functional recovery after hip fracture: the combined effects of depressive symptoms, cognitive impairment, and delirium. | Givens JL, Sanft TB, Marcantonio ER | Journal of the American Geriatrics Society | 2008 |
Activities of Daily Living, Aged, Cognition Disorders, epidemiology, Delirium, epidemiology, Depression, epidemiology, Female, Hip Fractures, mortality, Humans, Institutionalization, statistics & numerical data, Logistic Models, Male, Multivariate Analysis, Prevalence, Prospective Studies, Recovery of Function, Survival Rate, Treatment Outcome, United States, epidemiology |
| High risk of cognitive and functional decline after postoperative delirium. A three-year prospective study. | Bickel H, Gradinger R, Kochs E, Förstl H | Dementia and geriatric cognitive disorders | 2008 |
Aged, Aged, 80 and over, Arthroplasty, Replacement, Hip, statistics & numerical data, Cognition Disorders, epidemiology, Delirium, epidemiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Patient Discharge, Postoperative Complications, epidemiology, Predictive Value of Tests, Prospective Studies, Risk Factors |
| Delirium is associated with early postoperative cognitive dysfunction. | Rudolph JL, Marcantonio ER, Culley DJ, Silverstein JH, Rasmussen LS, Crosby GJ, Inouye SK | Anaesthesia | 2008 |
Aged, Cognition Disorders, epidemiology, Delirium, epidemiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Postoperative Complications, epidemiology, Postoperative Period, Prognosis, Risk Assessment |
| Risk factors for intensive care delirium: a systematic review. | Van Rompaey B, Schuurmans MJ, Shortridge-Baggett LM, Truijen S, Bossaert L | Intensive & critical care nursing : the official journal of the British Association of Critical Care Nurses | 2008 |
APACHE, Causality, Delirium, diagnosis, Health Facility Environment, Humans, Hypertension, complications, Incidence, Intensive Care, organization & administration, Intensive Care Units, organization & administration, Length of Stay, Mass Screening, Multivariate Analysis, Nursing Assessment, Prospective Studies, Research Design, Retrospective Studies, Risk Assessment, Syndrome |
| One-year health care costs associated with delirium in the elderly population. | Leslie DL, Marcantonio ER, Zhang Y, Leo-Summers L, Inouye SK | Archives of internal medicine | 2008 |
Aged, Aged, 80 and over, Delirium, economics, Female, Follow-Up Studies, Health Care Costs, Hospitalization, economics, Humans, Linear Models, Male, Time Factors |
| Reversibility of delirium in terminally ill patients and predictors of mortality. | Leonard M, Raju B, Conroy M, Donnelly S, Trzepacz PT, Saunders J, Meagher D | Palliative medicine | 2008 |
Aged, Aged, 80 and over, Delirium, diagnosis, Female, Humans, Male, Middle Aged, Prognosis, Recovery of Function, Severity of Illness Index, Survival Rate, Terminally Ill |
| A pilot study of rivastigmine in the treatment of delirium after stroke: a safe alternative. | Oldenbeuving AW, de Kort PL, Jansen BP, Kappelle LJ, Roks G | BMC neurology | 2008 |
Administration, Oral, Aged, Aged, 80 and over, Brain Ischemia, complications, Cholinesterase Inhibitors, administration & dosage, Delirium, drug therapy, Diarrhea, chemically induced, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Neuropsychological Tests, statistics & numerical data, Phenylcarbamates, administration & dosage, Pilot Projects, Psychiatric Status Rating Scales, statistics & numerical data, Stroke, complications, Treatment Outcome |
| Is preoperative anxiety and depression associated with onset of delirium after cardiac surgery in older patients? A prospective cohort study. | Detroyer E, Dobbels F, Verfaillie E, Meyfroidt G, Sergeant P, Milisen K | Journal of the American Geriatrics Society | 2008 |
Aged, Anxiety, complications, Cardiac Surgical Procedures, Delirium, epidemiology, Depression, complications, Female, Humans, Male, Middle Aged, Postoperative Complications, etiology, Prevalence, Prospective Studies |
| The 6- and 12-month outcomes of older medical inpatients who recover from subsyndromal delirium. | Cole MG, McCusker J, Ciampi A, Belzile E | Journal of the American Geriatrics Society | 2008 |
Activities of Daily Living, Aged, Aged, 80 and over, Cognition, Delirium, mortality, Female, Follow-Up Studies, Hospitalization, Humans, Male, Recovery of Function, Time Factors, Treatment Outcome |
| Delirium resolution in hospitalized older patients with cancer. | Bond SM, Neelon VJ | Cancer nursing | 2008 |
APACHE, Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Aging, Delirium, drug therapy, Female, Hospitalization, Humans, Length of Stay, Male, Neoplasms, complications, Psychological Tests, Psychometrics, Risk Factors |
| Pre-operative inflammatory markers and the risk of postoperative delirium in elderly patients. | Lemstra AW, Kalisvaart KJ, Vreeswijk R, van Gool WA, Eikelenboom P | International journal of geriatric psychiatry | 2008 |
Aged, Aged, 80 and over, Biological Markers, blood, C-Reactive Protein, metabolism, Case-Control Studies, Cognition Disorders, diagnosis, Delirium, diagnosis, Female, Hip Fractures, surgery, Humans, Inflammation, complications, Insulin-Like Growth Factor I, metabolism, Interleukin-6, metabolism, Male, Netherlands, Postoperative Complications, metabolism, Prospective Studies |
| Older people with delirium: worthless and childlike. | Neville S | International journal of nursing practice | 2008 |
Aged, Delirium, nursing, Geriatric Nursing, Humans |
| The 6 and 12 month outcomes of older medical inpatients who recover from delirium. | Cole MG, You Y, McCusker J, Ciampi A, Belzile E | International journal of geriatric psychiatry | 2008 |
Activities of Daily Living, Aged, Aged, 80 and over, Cognition Disorders, etiology, Delirium, psychology, Epidemiologic Methods, Female, Hospitalization, Humans, Male, Prognosis, Psychiatric Status Rating Scales |
| Delirium in the acute care setting: characteristics, diagnosis and treatment. | Maldonado JR | Critical care clinics | 2008 |
Aged, Algorithms, Delirium, diagnosis, Female, Geriatrics, Humans, Intelligence Tests, Length of Stay, Long-Term Care, methods, Male, Mental Disorders, chemically induced, Psychotropic Drugs, adverse effects, Reflex, Abnormal, Risk Factors, Severity of Illness Index, Torsades de Pointes, chemically induced |
| Chemokines are associated with delirium after cardiac surgery. | Rudolph JL, Ramlawi B, Kuchel GA, McElhaney JE, Xie D, Sellke FW, Khabbaz K, Levkoff SE, Marcantonio ER | The journals of gerontology. Series A, Biological sciences and medical sciences | 2008 |
Aged, Biological Markers, blood, Cardiac Surgical Procedures, Case-Control Studies, Chemokines, blood, Delirium, blood, Female, Flow Cytometry, Humans, Male, Middle Aged, Postoperative Complications, blood, Prospective Studies, Risk Factors |
| Delirium issues in palliative care settings. | Leonard M, Agar M, Mason C, Lawlor P | Journal of psychosomatic research | 2008 |
Cognition Disorders, epidemiology, Delirium, epidemiology, Humans, Hypnotics and Sedatives, therapeutic use, Palliative Care, methods, Patient Care, standards |
| Drug treatment of delirium: past, present and future. | Bourne RS, Tahir TA, Borthwick M, Sampson EL | Journal of psychosomatic research | 2008 |
Antipsychotic Agents, therapeutic use, Benzodiazepines, therapeutic use, Cholinesterase Inhibitors, therapeutic use, Delirium, classification, Drug Therapy, trends, Forecasting, Humans |
| Educating staff working in long-term care about delirium: the Trojan horse for improving quality of care? | Siddiqi N, Young J, Cheater FM, Harding RA | Journal of psychosomatic research | 2008 |
Delirium, physiopathology, Health Education, Health Personnel, education, Humans, Long-Term Care, Quality of Health Care, standards |
| Delirium phenomenology: what can we learn from the symptoms of delirium? | Gupta N, de Jonghe J, Schieveld J, Leonard M, Meagher D | Journal of psychosomatic research | 2008 |
Delirium, diagnosis, Diagnosis, Differential, Humans, International Classification of Diseases |
| Delirium detection in clinical practice and research: critique of current tools and suggestions for future development. | Kean J, Ryan K | Journal of psychosomatic research | 2008 |
Biomedical Research, statistics & numerical data, Delirium, diagnosis, Diagnosis, Differential, Forecasting, Humans, Mass Screening, methods, Physician’s Practice Patterns, statistics & numerical data |
| Defining delirium for the International Classification of Diseases, 11th Revision. | Meagher DJ, Maclullich AM, Laurila JV | Journal of psychosomatic research | 2008 |
Arousal, physiology, Cognition Disorders, epidemiology, Delirium, classification, Dementia, epidemiology, Diagnostic and Statistical Manual of Mental Disorders, Humans, International Classification of Diseases, Sleep Disorders, Circadian Rhythm, epidemiology |
| Neuroimaging studies of delirium: a systematic review. | Soiza RL, Sharma V, Ferguson K, Shenkin SD, Seymour DG, Maclullich AM | Journal of psychosomatic research | 2008 |
Brain, pathology, Delirium, diagnosis, Humans, Magnetic Resonance Imaging |
| The ethics of consent in delirium studies. | Holt R, Siddiqi N, Young J | Journal of psychosomatic research | 2008 |
Delirium, drug therapy, Drug Therapy, ethics, Drug and Narcotic Control, Ethics, Medical, Humans, Informed Consent, ethics, Personal Autonomy, Proxy |
| Designing clinical trials for the treatment of delirium. | Trzepacz PT, Bourne R, Zhang S | Journal of psychosomatic research | 2008 |
Delirium, drug therapy, Drug Therapy, methods, Humans, Randomized Controlled Trials as Topic, Research Design |
| Associations between caregiver-perceived delirium in patients with cancer and generalized anxiety in their caregivers. | Buss MK, Vanderwerker LC, Inouye SK, Zhang B, Block SD, Prigerson HG | Journal of palliative medicine | 2007 |
Adaptation, Psychological, Adult, Aged, Aged, 80 and over, Anxiety Disorders, psychology, Caregivers, psychology, Cognition, Cross-Sectional Studies, Delirium, etiology, Female, Health Surveys, Humans, Male, Mental Health, Middle Aged, Neoplasms, complications, Palliative Care, Perception, Psychological Tests, Psychometrics, Risk Assessment, Risk Factors, Stress, Psychological |
| Depressive symptoms and the risk of incident delirium in older hospitalized adults. | McAvay GJ, Van Ness PH, Bogardus ST, Zhang Y, Leslie DL, Leo-Summers LS, Inouye SK | Journal of the American Geriatrics Society | 2007 |
Aged, Aged, 80 and over, Cognition, Delirium, diagnosis, Depression, complications, Female, Hospitalization, Humans, Inpatients, psychology, Male, Proportional Hazards Models, Risk Factors |
| Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. | Inouye SK, Studenski S, Tinetti ME, Kuchel GA | Journal of the American Geriatrics Society | 2007 |
Accidental Falls, Activities of Daily Living, Aged, Aging, Biomedical Research, Cognition Disorders, complications, Delirium, etiology, Frail Elderly, Geriatrics, Health Policy, Humans, Mobility Limitation, Morbidity, Pressure Ulcer, etiology, Risk Factors, Syndrome, United States, Urinary Incontinence, etiology |
| Recognizing delirium superimposed on dementia: assessing nurses' knowledge using case vignettes. | Fick DM, Hodo DM, Lawrence F, Inouye SK | Journal of gerontological nursing | 2007 |
Adult, Aged, Causality, Clinical Competence, standards, Cross-Sectional Studies, Delirium, classification, Dementia, classification, Diagnosis, Differential, Female, Geriatric Assessment, methods, Geriatric Nursing, education, Geriatric Psychiatry, education, Humans, Knowledge, Male, Middle Aged, Nursing Assessment, methods, Nursing Education Research, Nursing Staff, Hospital, education, Patient Care Planning, Psychiatric Nursing, education, Questionnaires, Southeastern United States |
| Use of a computer-based reminder to improve sedative-hypnotic prescribing in older hospitalized patients. | Agostini JV, Zhang Y, Inouye SK | Journal of the American Geriatrics Society | 2007 |
Academic Medical Centers, Aged, Computer Systems, Drug Therapy, Computer-Assisted, Drug Utilization Review, Geriatric Assessment, Hospitalization, Humans, Hypnotics and Sedatives, therapeutic use, Medical Order Entry Systems, Physician’s Practice Patterns, statistics & numerical data, Point-of-Care Systems, Prospective Studies, Reminder Systems, Sleep Initiation and Maintenance Disorders, therapy |
| Recruitment of volunteers to improve vitality in the elderly: the REVIVE study. | Caplan GA, Harper EL | Internal medicine journal | 2007 |
Activities of Daily Living, psychology, Aged, Aged, 80 and over, Cost-Benefit Analysis, Delirium, economics, Female, Humans, Length of Stay, economics, Male, Volunteers |
| Independent vascular and cognitive risk factors for postoperative delirium. | Rudolph JL, Jones RN, Rasmussen LS, Silverstein JH, Inouye SK, Marcantonio ER | The American journal of medicine | 2007 |
Aged, Atherosclerosis, epidemiology, Cognition Disorders, epidemiology, Delirium, epidemiology, Female, Humans, Length of Stay, Male, Middle Aged, Myocardial Infarction, epidemiology, Risk Factors, Smoking, epidemiology, Surgical Procedures, Operative |
| Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. | Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW | JAMA : the journal of the American Medical Association | 2007 |
Aged, Coma, chemically induced, Conscious Sedation, economics, Delirium, chemically induced, Dexmedetomidine, administration & dosage, Double-Blind Method, Female, Humans, Hypnotics and Sedatives, administration & dosage, Intensive Care Units, economics, Lorazepam, administration & dosage, Male, Middle Aged, Neuropsychological Tests, Respiration, Artificial, economics |
| Efficacy of risperidone for prevention of postoperative delirium in cardiac surgery. | Prakanrattana U, Prapaitrakool S | Anaesthesia and intensive care | 2007 |
Antipsychotic Agents, therapeutic use, Coronary Artery Bypass, Delirium, epidemiology, Epidemiologic Methods, Female, Humans, Male, Middle Aged, Postoperative Complications, epidemiology, Risperidone, therapeutic use, Thailand, epidemiology, Treatment Outcome |
| Hyperactive delirium and blood glucose control in critically ill patients. | Heymann A, Sander M, Krahne D, Deja M, Weber-Carstens S, MacGuill M, Kastrup M, Wernecke KD, Nachtigall I, Spies CD | The Journal of international medical research | 2007 |
Adult, Aged, Blood Glucose, Critical Illness, Delirium, blood, Female, Humans, Male, Middle Aged, Retrospective Studies |
| Risk factors for delirium at discharge: development and validation of a predictive model. | Inouye SK, Zhang Y, Jones RN, Kiely DK, Yang F, Marcantonio ER | Archives of internal medicine | 2007 |
Aged, Delirium, epidemiology, Female, Humans, Length of Stay, Male, Models, Statistical, Patient Discharge, Risk Assessment, Risk Factors |
| Incidence, risk factors and consequences of ICU delirium. | Ouimet S, Kavanagh BP, Gottfried SB, Skrobik Y | Intensive care medicine | 2007 |
Delirium, epidemiology, Female, Humans, Incidence, Intensive Care Units, Male, Middle Aged, Prospective Studies, Risk Factors |
| Delirium in older patients in surgical intensive care units. | Balas MC, Deutschman CS, Sullivan-Marx EM, Strumpf NE, Alston RP, Richmond TS | Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing / Sigma Theta Tau | 2007 |
APACHE, Activities of Daily Living, Aged, Aged, 80 and over, Delirium, diagnosis, Dementia, complications, Depression, complications, Disease Progression, Female, Geriatric Assessment, Hospitals, University, Humans, Intensive Care Units, Length of Stay, statistics & numerical data, Male, Mental Status Schedule, Nursing Assessment, Patient Admission, Pennsylvania, epidemiology, Postoperative Complications, diagnosis, Prevalence, Prospective Studies, Questionnaires, Risk Factors |
| Characteristics associated with delirium in older patients in a medical intensive care unit. | Pisani MA, Murphy TE, Van Ness PH, Araujo KL, Inouye SK | Archives of internal medicine | 2007 |
Aged, Delirium, diagnosis, Female, Humans, Intensive Care Units, Male, Prospective Studies |
| Cytokines and acute phase response in delirium. | de Rooij SE, van Munster BC, Korevaar JC, Levi M | Journal of psychosomatic research | 2007 |
Activities of Daily Living, Acute-Phase Reaction, immunology, Aged, Aged, 80 and over, Alzheimer Disease, immunology, Cytokines, blood, Delirium, immunology, Disability Evaluation, Female, Geriatric Assessment, Humans, Interleukin-6, blood, Interleukin-8, blood, Male, Mental Status Schedule, Patient Admission, Patient Care Team, Reference Values |
| Delirium in elderly general medical inpatients: a prospective study. | Iseli RK, Brand C, Telford M, LoGiudice D | Internal medicine journal | 2007 |
Aged, Aged, 80 and over, Australia, epidemiology, Delirium, diagnosis, Female, Humans, Incidence, Male, Prevalence, Prospective Studies, Risk Factors |
| Associations of delirium with in-hospital and in 6-months mortality in elderly medical inpatients. | Adamis D, Treloar A, Darwiche FZ, Gregson N, Macdonald AJ, Martin FC | Age and ageing | 2007 |
Age Factors, Aged, Aged, 80 and over, Albumins, metabolism, Biological Markers, blood, C-Reactive Protein, metabolism, Data Interpretation, Statistical, Delirium, blood, Female, Hospital Mortality, trends, Humans, Inpatients, psychology, Interleukin-6, blood, Logistic Models, Male, Predictive Value of Tests, Prognosis, Prospective Studies |