What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Pharmacological interventions for the treatment of delirium in critically ill adults
- Authors
- Burry, L. Hutton, B. Williamson, D. R. Mehta, S. Adhikari, N. K. Cheng, W. Ely, E. W. Egerod, I. Fergusson, D. A. Rose, L.
- Year
- 2019
- Journal
- Cochrane Database Syst Rev
- Abstract
BACKGROUND: Although delirium is typically an acute reversible cognitive impairment, its presence is associated with devastating impact on both short-term and long-term outcomes for critically ill patients. Advances in our understanding of the negative impact of delirium on patient outcomes have prompted trials evaluating multiple pharmacological interventions. However, considerable uncertainty surrounds the relative benefits and safety of available pharmacological interventions for this population. OBJECTIVES: Primary objective1. To assess the effects of pharmacological interventions for treatment of delirium on duration of delirium in critically ill adults with confirmed or documented high risk of deliriumSecondary objectivesTo assess the following:1. effects of pharmacological interventions on delirium-free and coma-free days; days with coma; delirium relapse; duration of mechanical ventilation; intensive care unit (ICU) and hospital length of stay; mortality; and long-term outcomes (e.g. cognitive; discharge disposition; health-related quality of life); and2. the safety of such treatments for critically ill adult patients. SEARCH METHODS: We searched the following databases from their inception date to 21 March 2019: Ovid MEDLINE(R), Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Embase Classic+Embase, and PsycINFO using the Ovid platform. We also searched the Cochrane Library on Wiley, the International Prospective Register of Systematic Reviews (PROSPERO) (http://www.crd.york.ac.uk/PROSPERO/), the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. We performed a grey literature search of relevant databases and websites using the resources listed in Grey Matters developed by the Canadian Agency for Drugs and Technologies in Health (CADTH). We also searched trial registries and abstracts from annual scientific critical care and delirium society meetings. SELECTION CRITERIA: We sought randomized controlled trials (RCTs), including quasi-RCTs, of any pharmacological (drug) for treatment of delirium in critically ill adults. The drug intervention was to be compared to another active drug treatment, placebo, or a non-pharmacological intervention (e.g. mobilization). We did not apply any restrictions in terms of drug class, dose, route of administration, or duration of delirium or drug exposure. We defined critically ill patients as those treated in an ICU of any specialty (e.g. burn, cardiac, medical, surgical, trauma) or high-dependency unit. DATA COLLECTION AND ANALYSIS: Two review authors independently identified studies from the search results; four review authors (in pairs) performed data extraction and assessed risk of bias independently. We performed data synthesis through pairwise meta-analysis and network meta-analysis (NMA). Our hypothetical network structure was designed to be analysed at the drug class level and illustrated a network diagram of ‘nodes’ (i.e. drug classes) and ‘edges’ (i.e. comparisons between different drug classes from existing trials), thus describing a treatment network of all possible comparisons between drug classes. We assessed the quality of the body of evidence according to GRADE, as very low, low, moderate, or high. MAIN RESULTS: We screened 7674 citations, from which 14 trials with 1844 participants met our inclusion criteria. Ten RCTs were placebo-controlled, and four reported comparisons of different drugs. Drugs examined in these trials were the following: antipsychotics (n = 10), alpha2 agonists (n = 3; all dexmedetomidine), statins (n = 2), opioids (n = 1; morphine), serotonin antagonists (n = 1; ondansetron), and cholinesterase (CHE) inhibitors (n = 1; rivastigmine). Only one of these trials consistently used non-pharmacological interventions that are known to improve patient outcomes in both intervention and control groups.Eleven studies (n = 1153 participants) contributed to analysis of the primary outcome. Results of the NMA showed that the intervention with the smallest ratio of means (RoM) (i.e. most preferred) compared with placebo was the alpha2 agonist dexmedetomidine (0.58; 95% credible interval (CrI) 0.26 to 1.27; surface under the cumulative ranking curve (SUCRA) 0.895; moderate-quality evidence). In order of descending SUCRA values (best to worst), the next best interventions were atypical antipsychotics (RoM 0.80, 95% CrI 0.50 to 1.11; SUCRA 0.738; moderate-quality evidence), opioids (RoM 0.88, 95% CrI 0.37 to 2.01; SUCRA 0.578; very-low quality evidence), and typical antipsychotics (RoM 0.96, 95% CrI 0.64 to1.36; SUCRA 0.468; high-quality evidence).The NMAs of multiple secondary outcomes revealed that only the alpha2 agonist dexmedetomidine was associated with a shorter duration of mechanical ventilation (RoM 0.55, 95% CrI 0.34 to 0.89; moderate-quality evidence), and the CHE inhibitor rivastigmine was associated with a longer ICU stay (RoM 2.19, 95% CrI 1.47 to 3.27; moderate-quality evidence). Adverse events often were not reported in these trials or, when reported, were rare; pair-wise analysis of QTc prolongation in seven studies did not show significant differences between antipsychotics, ondansetron, dexmedetomidine, and placebo. AUTHORS’ CONCLUSIONS: We identified trials of varying quality that examined six different drug classes for treatment of delirium in critically ill adults. We found evidence that the alpha2 agonist dexmedetomidine may shorten delirium duration, although this small effect (compared with placebo) was seen in pairwise analyses based on a single study and was not seen in the NMA results. Alpha2 agonists also ranked best for duration of mechanical ventilation and length of ICU stay, whereas the CHE inhibitor rivastigmine was associated with longer ICU stay. We found no evidence of a difference between placebo and any drug in terms of delirium-free and coma-free days, days with coma, physical restraint use, length of stay, long-term cognitive outcomes, or mortality. No studies reported delirium relapse, resolution of symptoms, or quality of life. The ten ongoing studies and the six studies awaiting classification that we identified, once published and assessed, may alter the conclusions of the review.
- PMID
- Keywords
- Page(s)
- Volume
- 9
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| The short IQCODE as a predictor for delirium in hospitalized geriatric patients | Blandfort, S. Gregersen, M. Rahbek, K. Juul, S. Damsgaard, E. M. | Aging Clin Exp Res | 2019 |
Delirium predictor |
| The relationship among frailty, delirium and attentional tests to detect delirium: a cohort study | Bellelli, P. G. Biotto, M. Morandi, A. Meagher, D. Cesari, M. Mazzola, P. Annoni, G. Zambon, A. | Eur J Intern Med | 2019 |
Attention |
| Haloperidol for the treatment of delirium in critically ill patients: A systematic review with meta-analysis and Trial Sequential Analysis | Barbateskovic, M. Krauss, S. R. Collet, M. O. Andersen-Ranberg, N. C. Mathiesen, O. Jakobsen, J. C. Perner, A. Wetterslev, J. | Acta Anaesthesiologica Scandinavica | 2019 |
adult |
| The Volunteer Dementia and Delirium Care (VDDC) © Program: An Exploration of Perceived Barriers and Enablers to Implementation in an Acute and Subacute Metropolitan Hospital | Ayton, D. Moran, C. Berkovic, D. Bateman, C. Anderson, K. Blair, A. Soh, S. E. Morello, R. Ying Lim, Y. Liew, D. | Australas J Ageing | 2019 |
delirium |
| Comorbidities rather than age affect medium-term outcome in octogenarian patients after total knee arthroplasty | Andreozzi, V. Conteduca, F. Iorio, R. Di Stasio, E. Mazza, D. Drogo, P. Annibaldi, A. Ferretti, A. | Knee Surg Sports Traumatol Arthrosc | 2019 |
Comorbidity |
| Effect of the Tailored, Family-Involved Hospital Elder Life Program on Postoperative Delirium and Function in Older Adults: A Randomized Clinical Trial | Wang, Y. Y. Yue, J. R. Xie, D. M. Carter, P. Li, Q. L. Gartaganis, S. L. Chen, J. Inouye, S. K. | JAMA Intern Med | 2019 | |
| Nomogram for Predicting Postoperative Delirium After Deep Brain Stimulation Surgery for Parkinson's Disease | Wang, X. Q. Zhuang, H. X. Zhang, L. X. Chen, X. Niu, C. S. Zhao, M. | World Neurosurg | 2019 |
Deep brain stimulation |
| Automated tracking of level of consciousness and delirium in critical illness using deep learning | Sun, H. Kimchi, E. Akeju, O. Nagaraj, S. B. McClain, L. M. Zhou, D. W. Boyle, E. Zheng, W. L. Ge, W. Westover, M. B. | NPJ Digital Medicine | 2019 |
propofol |
| Impact of natural light exposure on delirium burden in adult patients receiving invasive mechanical ventilation in the ICU: a prospective study | Smonig, R. Magalhaes, E. Bouadma, L. Andremont, O. de Montmollin, E. Essardy, F. Mourvillier, B. Lebut, J. Dupuis, C. Neuville, M. Lermuzeaux, M. Timsit, J. F. Sonneville, R. | Ann Intensive Care | 2019 |
Agitation |
| Differences in 90-day mortality of delirium subtypes in the intensive care unit: A retrospective cohort study | Rood, P. J. T. van de Schoor, F. van Tertholen, K. Pickkers, P. van den Boogaard, M. | J Crit Care | 2019 |
Critical care |
| The Role of Delirium and Other Risk Factors on Mortality in Elderly Patients with Critical Limb Ischemia Undergoing Major Lower Limb Amputation | Roijers, J. P. Hopmans, C. J. Janssen, T. L. Mulder, P. G. H. Buimer, M. G. Ho, G. H. de Groot, H. G. W. Veen, E. J. van der Laan, L. | Ann Vasc Surg | 2019 | |
| Antipsychotics for preventing delirium in hospitalized adults a systematic review | Oh, E. S. Needham, D. M. Nikooie, R. Wilson, L. M. Zhang, A. Robinson, K. A. Neufeld, K. J. | Annals of Internal Medicine | 2019 |
neuroleptic agent |
| Antipsychotics for treating delirium in hospitalized adults a systematic review | Nikooie, R. Neufeld, K. J. Oh, E. S. Wilson, L. M. Zhang, A. Robinson, K. A. Needham, D. M. | Annals of Internal Medicine | 2019 |
amisulpride |
| Exploiting Machine Learning Algorithms and Methods for the Prediction of Agitated Delirium After Cardiac Surgery: Models Development and Validation Study | Mufti, H. N. Hirsch, G. M. Abidi, S. R. Abidi, S. S. R. | JMIR Med Inform | 2019 |
cardiac surgery |
| Predictors and prognosis of delirium among older subjects in cardiac intensive care unit: focus on potentially preventable forms | Mossello, E. Baroncini, C. Pecorella, L. Giulietti, C. Chiti, M. Caldi, F. Cavallini, M. C. Simoni, D. Baldasseroni, S. Fumagalli, S. Valoti, P. Stroppa, S. Parenti, K. Ungar, A. Masotti, G. Marchionni, N. Di Bari, M. | Eur Heart J Acute Cardiovasc Care | 2019 |
*Delirium |
| Dysfunction of the blood-brain barrier in postoperative delirium patients, referring to the axonal damage biomarker phosphorylated neurofilament heavy subunit | Mietani, K. Sumitani, M. Ogata, T. Shimojo, N. Inoue, R. Abe, H. Kawamura, G. Yamada, Y. | PLoS One | 2019 | |
| The 4 ‘a’s test for detecting delirium in acute medical patients: A diagnostic accuracy study | Maclullich, A. M. J. Shenkin, S. D. Goodacre, S. Godfrey, M. Hanley, J. Stíobhairt, A. Lavender, E. Boyd, J. Stephen, J. Weir, C. Macraild, A. Steven, J. Black, P. Diernberger, K. Hall, P. Tieges, Z. Fox, C. Anand, A. Young, J. Siddiqi, N. Gray, A. | Health Technology Assessment | 2019 |
ISRCTN53388093 |
| Initiation and continuation of antipsychotic medicines in older people following non-psychiatric hospital admission | Kalisch Ellett, L. M. Pratt, N. L. Apajee, J. Roughead, E. E. | Int J Clin Pharm | 2019 |
Antipsychotic |
| Staged Implementation of Awakening and Breathing, Coordination, Delirium Monitoring and Management, and Early Mobilization Bundle Improves Patient Outcomes and Reduces Hospital Costs | Hsieh, S. J. Otusanya, O. Gershengorn, H. B. Hope, A. A. Dayton, C. Levi, D. Garcia, M. Prince, D. Mills, M. Fein, D. Colman, S. Gong, M. N. | Critical Care Medicine | 2019 |
adult |
| The Prevalence of Delirium in An Older Acute Surgical Population and Its Effect on Outcome | Hewitt, J. Owen, S. Carter, B. R. Stechman, M. J. Tay, H. S. Greig, M. McCormack, C. Pearce, L. McCarthy, K. Myint, P. K. Moug, S. J. | Geriatrics | 2019 |
Cognitive impairment |
| Care challenges in older general hospital patients : Impact of cognitive impairment and other patient-related factors | Hendlmeier, I. Bickel, H. Hessler-Kaufmann, J. B. Schaufele, M. | Z Gerontol Geriatr | 2019 |
Adverse events |
| Efficacy of music on sedation, analgesia and delirium in critically ill patients. A systematic review of randomized controlled trials | Garcia Guerra, G. Almeida, L. Zorzela, L. King-Jones, S. Joffe, A. R. Hartling, L. Jou, H. Vohra, S. | J Crit Care | 2019 |
Analgesia |
| Postoperative Pressure Ulcers After Geriatric Hip Fracture Surgery Are Predicted by Defined Preoperative Comorbidities and Postoperative Complications | Galivanche, A. R. Kebaish, K. J. Adrados, M. Ottesen, T. D. Varthi, A. G. Rubin, L. E. Grauer, J. N. | The Journal of the American Academy of Orthopaedic Surgeons | 2019 |
adult |
| The Healthy Heart-Mind Trial: Randomized Controlled Trial of Melatonin for Prevention of Delirium | Ford, A. H. Flicker, L. Kelly, R. Patel, H. Passage, J. Wibrow, B. Anstey, M. Edwards, M. Almeida, O. P. | J Am Geriatr Soc | 2019 |
cardiothoracic |
| The Caregiver Burden of Delirium in Older Adults With Alzheimer Disease and Related Disorders | Fong, T. G. Racine, A. M. Fick, D. M. Tabloski, P. Gou, Y. Schmitt, E. M. Hshieh, T. T. Metzger, E. Bertrand, S. E. Marcantonio, E. R. Jones, R. N. Inouye, S. K. | J Am Geriatr Soc | 2019 |
Alzheimer disease |
| Geriatric Events Among Older Adults Undergoing Nonelective Surgery Are Associated with Poor Outcomes | Dworsky, J. Q. Childers, C. P. Copeland, T. Maggard-Gibbons, M. Tan, H. J. Saliba, D. Russell, M. M. | Am Surg | 2019 | |
| Shifting the focus: A QI project to improve the management of delirium in patients with hip fracture | Dormandy, L. Mufti, S. Higgins, E. Bailey, C. Dixon, M. | Future Healthc J | 2019 |
Neck of femur fracture |
| Impact of a delirium prevention project among older hospitalized patients who underwent orthopedic surgery: a retrospective cohort study | Choi, J. Y. Kim, K. I. Kang, M. G. Lee, Y. K. Koo, K. H. Oh, J. H. Park, Y. H. Suh, J. Kim, N. H. Yoo, H. J. Koo, J. Moon, H. M. Kim, E. H. Park, K. Kim, C. H. | BMC Geriatr | 2019 |
Delirium |
| Melatonin for the prevention of postoperative delirium in older adults: a systematic review and meta-analysis | Campbell, A. M. Axon, D. R. Martin, J. R. Slack, M. K. Mollon, L. Lee, J. K. | BMC Geriatr | 2019 |
Delirium |
| Assessment of a Geriatric Hip Fracture Program: Analysis of Harmful Adverse Events Using the Global Trigger Tool | Blood, T. D. Deren, M. E. Goodman, A. D. Hayda, R. A. Trafton, P. G. | Journal of Bone and Joint Surgery - American Volume | 2019 |
acute blood loss anemia |
| Clinical management of delirium: The response depends on the subtypes. An observational cohort study in 602 patients | Zipser, C. M. Knoepfel, S. Hayoz, P. Schubert, M. Ernst, J. von Kanel, R. Boettger, S. | Palliat Support Care | 2019 |
Antipsychotics |
| Predisposing and precipitating factors for delirium in neurology: a prospective cohort study of 1487 patients | Zipser, C. M. Deuel, J. Ernst, J. Schubert, M. Weller, M. von Kanel, R. Boettger, S. | J Neurol | 2019 |
Delirium |
| Risk factors for postoperative delirium after spinal surgery: a systematic review and meta-analysis | Zhu, C. Wang, B. Yin, J. Xue, Q. Gao, S. Xing, L. Wang, H. Liu, W. Liu, X. | Aging Clin Exp Res | 2019 |
Delirium |
| Dexmedetomidine for the prevention of postoperative delirium in elderly patients undergoing noncardiac surgery: A meta-analysis of randomized controlled trials | Zeng, H. Li, Z. He, J. Fu, W. | PLoS One | 2019 | |
| Risk factors for delirium: Are therapeutic interventions part of it? | Xing, J. Yuan, Z. Jie, Y. Liu, Y. Wang, M. Sun, Y. | Neuropsychiatric Disease and Treatment | 2019 |
arterial line |
| Intraoperative hyperglycemia increases the incidence of postoperative delirium | Windmann, V. Spies, C. Knaak, C. Wollersheim, T. Piper, S. K. Vorderwulbecke, G. Kurpanik, M. Kuenz, S. Lachmann, G. | Minerva Anestesiol | 2019 | |
| External Validation of Two Models to Predict Delirium in Critically Ill Adults Using Either the Confusion Assessment Method-ICU or the Intensive Care Delirium Screening Checklist for Delirium Assessment | Wassenaar, A. Schoonhoven, L. Devlin, J. W. van Haren, F. M. P. Slooter, A. J. C. Jorens, P. G. van der Jagt, M. Simons, K. S. Egerod, I. Burry, L. D. Beishuizen, A. Matos, J. Donders, A. R. T. Pickkers, P. van den Boogaard, M. | Crit Care Med | 2019 |
adult |
| Risk Factors and Incidence of Postoperative Delirium in Patients Undergoing Laryngectomy | Wang, Y. Yu, H. Qiao, H. Li, C. Chen, K. Shen, X. | Otolaryngol Head Neck Surg | 2019 |
head and neck cancer |
| Regional cerebral oxygen saturation and postoperative delirium in endovascular surgery: a prospective cohort study | Wang, X. Feng, K. Liu, H. Liu, Y. Ye, M. Zhao, G. Wang, T. | Trials | 2019 |
Delirium |
| The impact of analgosedation on mortality and delirium in critically ill patients: A systematic review and meta-analysis | Wang, C. T. Mao, Y. Zhao, L. Ma, B. | Intensive Crit Care Nurs | 2019 |
Analgesia-based sedation |
| Incidence and risk factors of postoperative delirium in patients admitted to the ICU after elective intracranial surgery: A prospective cohort study | Wang, C. M. Huang, H. W. Wang, Y. M. He, X. Sun, X. M. Zhou, Y. M. Zhang, G. B. Gu, H. Q. Zhou, J. X. | Eur J Anaesthesiol | 2019 | |
| Association between preoperative nutritional status and postoperative delirium in individuals with coronary artery bypass graft surgery: A prospective cohort study | Velayati, A. Vahdat Shariatpanahi, M. Shahbazi, E. Vahdat Shariatpanahi, Z. | Nutrition | 2019 |
adductor pollicis muscle |
| Prevalence and risk factors for delirium in elderly patients with severe burns: a retrospective cohort study | van Yperen, D. T. Raats, J. W. Dokter, J. Ziere, G. Roukema, G. R. van Baar, M. E. van der Vlies, C. H. | J Burn Care Res | 2019 |
Elderly |
| Delirium After Transcatheter Aortic Valve Implantation Under General Anesthesia: Incidence, Predictors, and Relation to Long-Term Survival | van der Wulp, K. van Wely, M. van Heijningen, L. van Bakel, B. Schoon, Y. Verkroost, M. Gehlmann, H. Van Garsse, L. Vart, P. Kievit, P. Rikkert, M. O. Morshuis, W. van Royen, N. | J Am Geriatr Soc | 2019 |
general anesthesia |
| Impact of a Premorbid Psychiatric Disorder on the Incidence of Delirium during ICU Stay, Morbidity, and Long-Term Mortality | van der Kuur, A. Bethlehem, C. Bruins, N. de Jager, C. van Alst, C. Haagsma, O. G. Keijzers, A. Boerma, E. C. | Crit Care Res Pract | 2019 | |
| Identifying determinants for the application of physical or chemical restraint in the management of psychomotor agitation on the critical care unit | Teece, A. Baker, J. Smith, H. | J Clin Nurs | 2019 |
agitation |
| Impact of a nurse engagement intervention on pain, agitation and delirium assessment in a community intensive care unit | Tan, C. M. Camargo, M. Miller, F. Ross, K. Maximous, R. Yung, P. Marshall, C. Fleming, D. Law, M. Tsang, J. L. | BMJ Open Qual | 2019 |
critical care |
| Predictors of delirium after cardiac surgery in patients with sleep disordered breathing | Tafelmeier, M. Knapp, M. Lebek, S. Floerchinger, B. Camboni, D. Creutzenberg, M. Wittmann, S. Zeman, F. Schmid, C. Maier, L. S. Wagner, S. Arzt, M. | Eur Respir J | 2019 | |
| The relationship between obstructive sleep apnoea and postoperative delirium and pain: an observational study of a surgical cohort | Strutz, P. K. Kronzer, V. Tzeng, W. Arrington, B. McKinnon, S. L. Ben Abdallah, A. Haroutounian, S. Avidan, M. S. | Anaesthesia | 2019 |
delirium |
| Ultra-brief Screeners for Detecting Delirium Superimposed on Dementia | Steensma, E. Zhou, W. Ngo, L. Gallagher, J. Inouye, S. Leslie, D. Boltz, M. Kolanowski, A. Mion, L. Marcantonio, E. R. Fick, D. | J Am Med Dir Assoc | 2019 |
Delirium |
| Etiology and Related Factors of Postoperative Delirium in Orthopedic Surgery | Song, K. J. Ko, J. H. Kwon, T. Y. Choi, B. W. | Clin Orthop Surg | 2019 |
Delirium |
| Preoperative transcranial Doppler and cerebral oximetry as predictors of delirium following valvular heart surgery: a case-control study | Soh, S. Shim, J. K. Song, J. W. Choi, N. Kwak, Y. L. | J Clin Monit Comput | 2019 |
Cardiac surgical procedures |
| Identification of Patients With High Mortality Risk and Prediction of Outcomes in Delirium by Bispectral EEG | Shinozaki, G. Bormann, N. L. Chan, A. C. Zarei, K. Sparr, N. A. Klisares, M. J. Jellison, S. S. Heinzman, J. T. Dahlstrom, E. B. Duncan, G. N. Gaul, L. N. Wanzek, R. J. Cramer, E. M. Wimmel, C. G. Sabbagh, S. Yuki, K. Weckmann, M. T. Yamada, T. Karam, M. | J Clin Psychiatry | 2019 | |
| Postoperative Delirium Is Associated with Long-term Decline in Activities of Daily Living | Shi, Z. Mei, X. Li, C. Chen, Y. Zheng, H. Wu, Y. Zheng, H. Liu, L. Marcantonio, E. R. Xie, Z. Shen, Y. | Anesthesiology | 2019 | |
| Managing Delirium and Agitation in the Older Emergency Department Patient: The ADEPT Tool | Shenvi, C. Kennedy, M. Austin, C. A. Wilson, M. P. Gerardi, M. Schneider, S. | Ann Emerg Med | 2019 | |
| Delirium detection in older acute medical inpatients: a multicentre prospective comparative diagnostic test accuracy study of the 4AT and the confusion assessment method | Shenkin, S. D. Fox, C. Godfrey, M. Siddiqi, N. Goodacre, S. Young, J. Anand, A. Gray, A. Hanley, J. MacRaild, A. Steven, J. Black, P. L. Tieges, Z. Boyd, J. Stephen, J. Weir, C. J. MacLullich, A. M. J. | BMC Med | 2019 |
*4at |
| Occurrence Rate of Delirium in Acute Stroke Settings: Systematic Review and Meta-Analysis | Shaw, R. C. Walker, G. Elliott, E. Quinn, T. J. | Stroke | 2019 |
delirium |
| Delirium in an Acute Stroke Setting, Occurrence, and Risk Factors | Shaw, R. Drozdowska, B. Taylor-Rowan, M. Elliott, E. Cuthbertson, G. Stott, D. J. Quinn, T. J. | Stroke | 2019 |
cognitive dysfunction |
| The relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium | Shariatpanahi, M. V. Velayati, A. Jamalian, S. A. Babevaynejad, M. Shariatpanahi, Z. V. | Neuropsychiatric Disease and Treatment | 2019 |
cobalamin |
| The effect of volunteers' care and support on the health outcomes of older adults in acute care: A systematic scoping review | Saunders, R. Seaman, K. Graham, R. Christiansen, A. | J Clin Nurs | 2019 |
Volunteers |
| Mitochondrial DNA Haplogroups and Delirium During Sepsis | Samuels, D. C. Hulgan, T. Fessel, J. P. Billings, F. T. th Thompson, J. L. Chandrasekhar, R. Girard, T. D. | Crit Care Med | 2019 | |
| Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial | Rosa, R. G. Falavigna, M. da Silva, D. B. Sganzerla, D. Santos, M. M. S. Kochhann, R. de Moura, R. M. Eugenio, C. S. Haack, Tdsr Barbosa, M. G. Robinson, C. C. Schneider, D. de Oliveira, D. M. Jeffman, R. W. Cavalcanti, A. B. Machado, F. R. Azevedo, L. C. | JAMA | 2019 |
Anxiety |
| Deconstructing Poststroke Delirium in a Prospective Cohort of Patients With Intracerebral Hemorrhage | Reznik, M. E. Drake, J. Margolis, S. A. Moody, S. Murray, K. Costa, S. Mahta, A. Wendell, L. C. Thompson, B. B. Rao, S. S. Barrett, A. M. Boukrina, O. Daiello, L. A. Asaad, W. F. Furie, K. L. Jones, R. N. | Crit Care Med | 2019 | |
| Impact of intraoperative blood pressure, blood pressure fluctuation, and pulse pressure on postoperative delirium in elderly patients with hip fracture: A prospective cohort study | Radinovic, K. Markovic Denic, L. Milan, Z. Cirkovic, A. Baralic, M. Bumbasirevic, V. | Injury | 2019 |
Blood pressure |
| Economic impact of delirium in Australia: a cost of illness study | Pezzullo, L. Streatfeild, J. Hickson, J. Teodorczuk, A. Agar, M. R. Caplan, G. A. | BMJ Open | 2019 |
delirium & cognitive disorders |
| Delirium Predisposing and Triggering Factors in Nursing Home Residents: A Cohort Trial-Nested Case-Control Study | Pérez-Ros, P. Martínez-Arnau, F. M. Baixauli-Alacreu, S. Caballero-Pérez, M. García-Gollarte, J. F. Tarazona-Santabalbina, F. | Journal of Alzheimer's Disease | 2019 |
urinary catheter |
| Preoperative C-Reactive Protein/Albumin Ratio, a Risk Factor for Postoperative Delirium in Elderly Patients After Total Joint Arthroplasty | Peng, J. Wu, G. Chen, J. Chen, H. | Journal of Arthroplasty | 2019 |
aged |
| Combination of lithium and electroconvulsive therapy (ECT) is associated with higher odds of delirium and cognitive problems in a large national sample across the United States | Patel, R. S. Bachu, A. Youssef, N. A. | Brain Stimul | 2019 |
Bipolar disorder |
| The long-term prognosis of patients with delirium in the acute phase of stroke: PRospective Observational POLIsh Study (PROPOLIS) | Pasinska, P. Wilk, A. Kowalska, K. Szyper-Maciejowska, A. Klimkowicz-Mrowiec, A. | J Neurol | 2019 |
Delirium |
| Postoperative Delirium is Associated with Negative Outcomes and Long-Term Mortality in Elderly Koreans: A Retrospective Observational Study | Park, E. A. Kim, M. Y. | Medicina (Kaunas) | 2019 |
delirium |
| Development of a Tool for the Assessment of Nurses' Attitudes Toward Delirium | Papastavrou, E. Papaioannou, M. Evripidou, M. Tsangari, H. Kouta, C. Merkouris, A. | J Nurs Meas | 2019 |
attitude |
| The risk factors associated with delirium after lumbar spine surgery in elderly patients | Pan, Z. Huang, K. Huang, W. Kim, K. H. Wu, H. Yu, Y. Kim, K. N. Yi, S. Shin, D. A. Vora, D. Gragnaniello, C. Phan, K. Tasiou, A. Winder, M. J. Koga, H. Azimi, P. Kang, S. Y. Ha, Y. | Quantitative Imaging in Medicine and Surgery | 2019 |
angiotensin receptor antagonist |
| Incidence, risk factors, and cumulative risk of delirium among ICU patients: A case-control study | Pan, Y. Yan, J. Jiang, Z. Luo, J. Zhang, J. Yang, K. | International Journal of Nursing Sciences | 2019 |
analgesic agent |
| Perioperative dexmedetomidine reduces delirium in elderly patients after non-cardiac surgery: a systematic review and meta-analysis of randomized-controlled trials | Pan, H. Liu, C. Ma, X. Xu, Y. Zhang, M. Wang, Y. | Can J Anaesth | 2019 | |
| International analgesia, sedation, and delirium practices: A prospective cohort study | Owen, G. D. Stollings, J. L. Rakhit, S. Wang, L. Yu, C. Hosay, M. A. Stewart, J. W. Frutos-Vivar, F. Peñuelas, O. Esteban, A. Anzueto, A. R. Raymondos, K. Rios, F. Thille, A. W. González, M. Du, B. Maggiore, S. M. Matamis, D. Abroug, F. Amin, P. Zeggwag | Journal of Intensive Care | 2019 |
NCT02731898 |
| Validation of 3-minute diagnostic interview for CAM-defined Delirium to detect postoperative delirium in the recovery room: A prospective diagnostic study | Olbert, M. Eckert, S. Morgeli, R. Kruppa, J. Spies, C. D. | Eur J Anaesthesiol | 2019 | |
| Antipsychotics for Preventing Delirium in Hospitalized Adults: A Systematic Review | Oh, E. S. Needham, D. M. Nikooie, R. Wilson, L. M. Zhang, A. Robinson, K. A. Neufeld, K. J. | Ann Intern Med | 2019 | |
| Prevention of Early Postoperative Decline: A Randomized, Controlled Feasibility Trial of Perioperative Cognitive Training | O'Gara, B. P. Mueller, A. Gasangwa, D. V. I. Patxot, M. Shaefi, S. Khabbaz, K. Banner-Goodspeed, V. Pascal-Leone, A. Marcantonio, E. R. Subramaniam, B. | Anesth Analg | 2019 | |
| Antipsychotics for Treating Delirium in Hospitalized Adults: A Systematic Review | Nikooie, R. Neufeld, K. J. Oh, E. S. Wilson, L. M. Zhang, A. Robinson, K. A. Needham, D. M. | Ann Intern Med | 2019 | |
| Characteristics of Hospitalized Patients Screening Positive for Delirium | Nguyen, T. H. Atayee, R. S. Derry, K. L. Hirst, J. Biondo, A. Edmonds, K. P. | Am J Hosp Palliative Care | 2019 |
Cam-icu |
| The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis | Ng, K. T. Teoh, W. Y. Khor, A. J. | J Clin Anesth | 2019 |
Agitation |
| Predicting medication-associated altered mental status in hospitalized patients: Development and validation of a risk model | Muñoz, M. A. Jeon, N. Staley, B. Henriksen, C. Xu, D. Weberpals, J. Winterstein, A. G. | American Journal of Health-System Pharmacy | 2019 |
adult |
| Exploiting Machine Learning Algorithms and Methods for the Prediction of Agitated Delirium after Cardiac Surgery | Mufti, H. N. Hirsch, G. M. Abidi, S. R. Abidi, S. S. R. | JMIR Med Inform | 2019 | |
| Risk factors for postoperative delirium in patients undergoing lower extremity joint arthroplasty: a retrospective population-based cohort study | Memtsoudis, S. Cozowicz, C. Zubizarreta, N. Weinstein, S. M. Liu, J. Kim, D. H. Poultsides, L. Berger, M. M. Mazumdar, M. Poeran, J. | Reg Anesth Pain Med | 2019 |
adverse effects |
| Comparison of the incidence and severity of delirium and biochemical factors after coronary artery bypass grafting with dexmedetomidine: A randomized double-blind placebo-controlled clinical trial study | Massoumi, G. Mansouri, M. Khamesipour, S. | ARYA Atherosclerosis | 2019 |
IRCT20171104037209N1 |
| Old Habits Die Hard: Antipsychotics for Treatment of Delirium | Marcantonio, E. R. | Ann Intern Med | 2019 | |
| Episodes of psychomotor agitation among medical patients: findings from a longitudinal multicentre study | Mansutti, I. Venturini, M. Palese, A. | Aging Clin Exp Res | 2019 |
Longitudinal |
| The 4 'A's test for detecting delirium in acute medical patients: a diagnostic accuracy study | MacLullich, A. M. Shenkin, S. D. Goodacre, S. Godfrey, M. Hanley, J. Stiobhairt, A. Lavender, E. Boyd, J. Stephen, J. Weir, C. MacRaild, A. Steven, J. Black, P. Diernberger, K. Hall, P. Tieges, Z. Fox, C. Anand, A. Young, J. Siddiqi, N. Gray, A. | Health Technol Assess | 2019 |
4at |
| Promoting sleep and circadian health may prevent postoperative delirium: A systematic review and meta-analysis of randomized clinical trials | Lu, Y. Li, Y. W. Wang, L. Lydic, R. Baghdoyan, H. A. Shi, X. Y. Zhang, H. | Sleep Med Rev | 2019 |
Meta-analysis |
| A Pilot Study of the Use of Dexmedetomidine for the Control of Delirium by Reducing the Serum Concentrations of Brain-Derived Neurotrophic Factor, Neuron-Specific Enolase, and S100B in Polytrauma Patients | Li, Y. Yu, Z. X. Ji, M. S. Yan, J. Cai, Y. Liu, J. Yang, H. F. Jin, Z. C. | J Intensive Care Med | 2019 |
S100b |
| Effectiveness and harms of pharmacological interventions for the treatment of delirium in adults in intensive care units after cardiac surgery: a systematic review | Leigh, V. Stern, C. Elliott, R. Tufanaru, C. | JBI Database System Rev Implement Rep | 2019 | |
| Physical Activity and Risk of Postoperative Delirium | Lee, S. S. Lo, Y. Verghese, J. | J Am Geriatr Soc | 2019 |
cognitive reserve |
| Predictive Ability of a Serious Game to Identify Emergency Patients With Unrecognized Delirium | Lee, J. S. Tong, T. Tierney, M. C. Kiss, A. Chignell, M. | J Am Geriatr Soc | 2019 |
delirium recognition |
| Could Neutrophil-to-Lymphocyte Ratio (NLR) Serve as a Potential Marker for Delirium Prediction in Patients with Acute Ischemic Stroke? A Prospective Observational Study | Kotfis, K. Bott-Olejnik, M. Szylinska, A. Rotter, I. | J Clin Med | 2019 |
*Crp |
| C-reactive protein for risk prediction of post-operative delirium and post-operative neurocognitive disorder | Knaak, C. Vorderwulbecke, G. Spies, C. Piper, S. K. Hadzidiakos, D. Borchers, F. Brockhaus, W. R. Radtke, F. M. Lachmann, G. | Acta Anaesthesiol Scand | 2019 |
C-reactive protein (CRP) |
| Clinical EEG slowing correlates with delirium severity and predicts poor clinical outcomes | Kimchi, E. Y. Neelagiri, A. Whitt, W. Sagi, A. R. Ryan, S. L. Gadbois, G. Groothuysen, D. Westover, M. B. | Neurology | 2019 | |
| Development of a Risk Score to Predict Postoperative Delirium in Patients With Hip Fracture | Kim, E. M. Li, G. Kim, M. | Anesth Analg | 2019 | |
| Assessment of Delirium Using the Confusion Assessment Method in Older Adult Inpatients in Malaysia | Khor, H. M. Ong, H. C. Tan, B. K. Low, C. M. Saedon, N. Tan, K. M. Chin, A. V. Kamaruzzaman, S. B. Tan, M. P. | Geriatrics (Basel) | 2019 |
Malaysia |
| The value of screening for cognition, depression, and frailty in patients referred for TAVI | Khan, M. M. Lanctôt, K. L. Fremes, S. E. Wijeysundera, H. C. Radhakrishnan, S. Gallagher, D. Gandell, D. Brenkel, M. C. Hazan, E. L. Docteur, N. G. Herrmann, N. | Clinical Interventions in Aging | 2019 |
activity of daily living assessment |
| Medication Use and Risk of Delirium in Mechanically Ventilated Patients | Jin, T. Jin, Y. Lee, S. M. | Clin Nurs Res | 2019 |
delirium |