What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Pharmacological interventions for the treatment of delirium in critically ill adults
- Authors
- Burry, L. Hutton, B. Williamson, D. R. Mehta, S. Adhikari, N. K. Cheng, W. Ely, E. W. Egerod, I. Fergusson, D. A. Rose, L.
- Year
- 2019
- Journal
- Cochrane Database Syst Rev
- Abstract
BACKGROUND: Although delirium is typically an acute reversible cognitive impairment, its presence is associated with devastating impact on both short-term and long-term outcomes for critically ill patients. Advances in our understanding of the negative impact of delirium on patient outcomes have prompted trials evaluating multiple pharmacological interventions. However, considerable uncertainty surrounds the relative benefits and safety of available pharmacological interventions for this population. OBJECTIVES: Primary objective1. To assess the effects of pharmacological interventions for treatment of delirium on duration of delirium in critically ill adults with confirmed or documented high risk of deliriumSecondary objectivesTo assess the following:1. effects of pharmacological interventions on delirium-free and coma-free days; days with coma; delirium relapse; duration of mechanical ventilation; intensive care unit (ICU) and hospital length of stay; mortality; and long-term outcomes (e.g. cognitive; discharge disposition; health-related quality of life); and2. the safety of such treatments for critically ill adult patients. SEARCH METHODS: We searched the following databases from their inception date to 21 March 2019: Ovid MEDLINE(R), Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Embase Classic+Embase, and PsycINFO using the Ovid platform. We also searched the Cochrane Library on Wiley, the International Prospective Register of Systematic Reviews (PROSPERO) (http://www.crd.york.ac.uk/PROSPERO/), the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. We performed a grey literature search of relevant databases and websites using the resources listed in Grey Matters developed by the Canadian Agency for Drugs and Technologies in Health (CADTH). We also searched trial registries and abstracts from annual scientific critical care and delirium society meetings. SELECTION CRITERIA: We sought randomized controlled trials (RCTs), including quasi-RCTs, of any pharmacological (drug) for treatment of delirium in critically ill adults. The drug intervention was to be compared to another active drug treatment, placebo, or a non-pharmacological intervention (e.g. mobilization). We did not apply any restrictions in terms of drug class, dose, route of administration, or duration of delirium or drug exposure. We defined critically ill patients as those treated in an ICU of any specialty (e.g. burn, cardiac, medical, surgical, trauma) or high-dependency unit. DATA COLLECTION AND ANALYSIS: Two review authors independently identified studies from the search results; four review authors (in pairs) performed data extraction and assessed risk of bias independently. We performed data synthesis through pairwise meta-analysis and network meta-analysis (NMA). Our hypothetical network structure was designed to be analysed at the drug class level and illustrated a network diagram of ‘nodes’ (i.e. drug classes) and ‘edges’ (i.e. comparisons between different drug classes from existing trials), thus describing a treatment network of all possible comparisons between drug classes. We assessed the quality of the body of evidence according to GRADE, as very low, low, moderate, or high. MAIN RESULTS: We screened 7674 citations, from which 14 trials with 1844 participants met our inclusion criteria. Ten RCTs were placebo-controlled, and four reported comparisons of different drugs. Drugs examined in these trials were the following: antipsychotics (n = 10), alpha2 agonists (n = 3; all dexmedetomidine), statins (n = 2), opioids (n = 1; morphine), serotonin antagonists (n = 1; ondansetron), and cholinesterase (CHE) inhibitors (n = 1; rivastigmine). Only one of these trials consistently used non-pharmacological interventions that are known to improve patient outcomes in both intervention and control groups.Eleven studies (n = 1153 participants) contributed to analysis of the primary outcome. Results of the NMA showed that the intervention with the smallest ratio of means (RoM) (i.e. most preferred) compared with placebo was the alpha2 agonist dexmedetomidine (0.58; 95% credible interval (CrI) 0.26 to 1.27; surface under the cumulative ranking curve (SUCRA) 0.895; moderate-quality evidence). In order of descending SUCRA values (best to worst), the next best interventions were atypical antipsychotics (RoM 0.80, 95% CrI 0.50 to 1.11; SUCRA 0.738; moderate-quality evidence), opioids (RoM 0.88, 95% CrI 0.37 to 2.01; SUCRA 0.578; very-low quality evidence), and typical antipsychotics (RoM 0.96, 95% CrI 0.64 to1.36; SUCRA 0.468; high-quality evidence).The NMAs of multiple secondary outcomes revealed that only the alpha2 agonist dexmedetomidine was associated with a shorter duration of mechanical ventilation (RoM 0.55, 95% CrI 0.34 to 0.89; moderate-quality evidence), and the CHE inhibitor rivastigmine was associated with a longer ICU stay (RoM 2.19, 95% CrI 1.47 to 3.27; moderate-quality evidence). Adverse events often were not reported in these trials or, when reported, were rare; pair-wise analysis of QTc prolongation in seven studies did not show significant differences between antipsychotics, ondansetron, dexmedetomidine, and placebo. AUTHORS’ CONCLUSIONS: We identified trials of varying quality that examined six different drug classes for treatment of delirium in critically ill adults. We found evidence that the alpha2 agonist dexmedetomidine may shorten delirium duration, although this small effect (compared with placebo) was seen in pairwise analyses based on a single study and was not seen in the NMA results. Alpha2 agonists also ranked best for duration of mechanical ventilation and length of ICU stay, whereas the CHE inhibitor rivastigmine was associated with longer ICU stay. We found no evidence of a difference between placebo and any drug in terms of delirium-free and coma-free days, days with coma, physical restraint use, length of stay, long-term cognitive outcomes, or mortality. No studies reported delirium relapse, resolution of symptoms, or quality of life. The ten ongoing studies and the six studies awaiting classification that we identified, once published and assessed, may alter the conclusions of the review.
- PMID
- Keywords
- Page(s)
- Volume
- 9
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Assessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties | Hanlon, P. Quinn, T. J. Gallacher, K. I. Myint, P. K. Jani, B. D. Nicholl, B. I. Lowrie, R. Soiza, R. L. Neal, S. R. Lee, D. Mair, F. S. | Ann Fam Med | 2020 |
anticholinergic burden |
| Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis | Han, Y. Wu, J. Qin, Z. Fu, W. Zhao, B. Li, X. Wang, W. Sha, T. Sun, M. Li, J. Zeng, Z. Chen, Z. | J Pineal Res | 2020 |
melatonin |
| Proteomic Analysis of Preoperative CSF Reveals Risk Biomarkers of Postoperative Delirium | Han, Y. Chen, W. Song, Y. Yuan, Y. Li, Z. Zhou, Y. Liu, T. Han, D. Mi, X. Li, M. Wang, G. Zhong, L. Zhou, J. Guo, X. | Front Psychiatry | 2020 |
cerebrospinal fluid |
| Inpatient gastrostomy in Huntington's disease: Nationwide analysis of utilization and outcomes compared to amyotrophic lateral sclerosis | Hamedani, A. G. Pauly, M. Thibault, D. P. Gonzalez-Alegre, P. Willis, A. W. | Clinical Parkinsonism and Related Disorders | 2020 |
Huntington’s disease Health services research Outcome research Gastrostomy |
| The Observational Scale of Level of Arousal: A brief tool for assessing and monitoring level of arousal in patients with delirium outside the ICU | Hall, R. Stíobhairt, A. Allerhand, M. MacLullich, A. M. J. Tieges, Z. | Int J Geriatr Psychiatry | 2020 |
arousal |
| Development of disturbance of consciousness is associated with increased severity in acute pancreatitis | Hágendorn, R. Vincze, Á Izbéki, F. Gajdán, L. Gódi, S. Illés, A. Sarlós, P. Farkas, N. Erőss, B. Lillik, V. Illés, D. Varjú, P. Márta, K. Török, I. Papp, M. Vitális, Z. Bod, B. Hamvas, J. Szepes, Z. Takács, T. Czakó, L. Márton, Z. Szentes | Pancreatology | 2020 |
Acute pancreatitis |
| Prophylactic Physostigmine for Extreme and Refractory Adult Emergence Delirium, Aimed at Increasing Patient Safety and Reducing Health Care Workplace Violence: A Case Report | Gutman, D. A. Hassid, M. Jeanes, Z. Redding, A. T. Romeo, D. | A and A Practice | 2020 |
adult |
| No Brain Is an Island | Guay, C. S. Avidan, M. S. | Anesth Analg | 2020 |
Brain |
| The role of physical exercise and rehabilitation in delirium | Gual, N. García-Salmones, M. Brítez, L. Crespo, N. Udina, C. Pérez, L. M. Inzitari, M. | European Geriatric Medicine | 2020 |
brain function |
| The incidence of prolonged post-electroconvulsive therapy delirium: A retrospective study | Grover, S. Kumar, A. Chakrabarti, S. Avasthi, A. | Indian J Psychiatry | 2020 |
Electroconvulsive therapy |
| Postoperative Delirium in Patients after Hip Fracture Tratment Postoperative Delirium in Patients after Hip Fracture Tratment | Grle, M. Markotić, V. Prlić, J. Grle, I. Miljko, M. | Psychiatr Danub | 2020 | |
| Intensive Care Unit Delirium, Clinical Observations, and Patients' Statements: A Case Study | Granberg-Axèll, A. Bergbom, I. | Dimensions of critical care nursing : DCCN | 2020 |
adult |
| Assessment of the Decision-Making Capacity for Clinical Research Participation in Patients With Advanced Cancer in the Last Weeks of Life | Goswami, R. Moore, J. Bruera, E. Hui, D. | Journal of Pain and Symptom Management | 2020 |
adult |
| Reducing Delirium in Hospitalized Adults Through a Structured Sleep Promotion Program | Gode, A. Kozub, E. Joerger, K. Lynch, C. Roche, M. Kirven, J. | J Nurs Care Qual | 2020 | |
| Preoperative Cognitive Assessment Recommendations for the Older Adult | Glover, N. P. Tola, D. H. Norcross, W. Naumuk, L. Tocchi, C. | J Perianesth Nurs | 2020 |
Mini-Cog |
| Use of Direct In-Person Observation in the Care of Hospitalized Older Adults with Cognitive Impairment: A Systematic Review | Gilmore-Bykovskyi, A. L. Fuhr, H. Jin, Y. Benson, C. | J Gerontol Nurs | 2020 | |
| The consistent burden in published estimates of delirium occurrence in medical inpatients over four decades: a systematic review and meta-analysis study | Gibb, K. Seeley, A. Quinn, T. Siddiqi, N. Shenkin, S. Rockwood, K. Davis, D. | Age Ageing | 2020 |
delirium |
| Loss of Independence in Older Patients after Operation for Colorectal Cancer | Gearhart, S. L. Do, E. M. Owodunni, O. Gabre-Kidan, A. A. Magnuson, T. | J Am Coll Surg | 2020 | |
| Time to Block: Early Regional Anesthesia Improves Pain Control in Geriatric Hip Fractures | Garlich, J. M. Pujari, A. Debbi, E. M. Yalamanchili, D. R. Moak, Z. B. Stephenson, S. K. Stephan, S. R. Polakof, L. S. Johnson, C. R. Noorzad, A. S. Little, M. T. M. Moon, C. N. Black, J. T. Anand, K. K. Lin, C. A. | J Bone Joint Surg Am | 2020 |
Brain |
| Encephalopathy in patients with COVID-19: A review | Garg, R. K. Paliwal, V. K. Gupta, A. | J Med Virol | 2020 |
Brain |
| Prevalence and risk factors of postoperative delirium after spinal surgery: a meta-analysis | Gao, H. Ma, H. J. Li, Y. J. Yin, C. Li, Z. | J Orthop Surg Res | 2020 |
Delirium |
| Prognostic factors for discharge to home and residing at home 12 months after hip fracture: an Anoia hip study | Gamboa-Arango, A. Duaso, E. Malafarina, V. Formiga, F. Marimón, P. Sandiumenge, M. Salgado, M. T. Escalante, E. Lumbreras, C. Tarrida, A. | Aging Clinical and Experimental Research | 2020 |
aged |
| Safety of the muscarinic receptor-antagonist (R,R)-penehyclidine fumarate in healthy subjects: A phase 1 randomized, double-blind, single-dose escalation study | Fu, C. Zhang, X. Pei, Q. Guo, C. Yang, X. Yang, S. Huang, J. Yang, G. | Int J Clin Pharmacol Ther | 2020 |
Administration, Oral |
| Discriminant Performance of Dysexecutive and Frontal Release Signs for Delirium in Patients With High Dementia Prevalence: Implications for Neural Network Impairment | Franco, J. G. Trzepacz, P. T. Velásquez-Tirado, J. D. Ocampo, M. V. Serna, P. A. Giraldo, A. M. López, C. Zuluaga, A. Zaraza-Morales, D. | Psychosomatics | 2020 |
abnormal reflex |
| Survey of psychiatrists and psychiatry residents in Colombia about their preventive and therapeutic practices in delirium | Franco, J. G. Oviedo Lugo, G. F. Patarroyo Rodriguez, L. Bernal Miranda, J. Molano, J. C. Rojas Moreno, M. Cardeño, C. Velasquez Tirado, J. D. | Revista Colombiana de Psiquiatria | 2020 |
Antipsychotics Delirium Health education Primary prevention Quality of healthcare Therapeutics |
| Adverse Events, Functional Decline, and Access to Allied Health Therapies for Patients With Dementia During Acute Hospitalization | Fox, A. MacAndrew, M. Wyles, K. Yelland, C. Beattie, E. | J Appl Gerontol | 2020 |
acute care |
| Outcomes of video-assisted thoracoscopic surgery lobectomy in septuagenarians | Fong, L. S. Ko, V. McLaughlin, A. Okiwelu, N. L. Newman, M. A. Passage, J. Sanders, L. H. A. Joshi, P. V. | ANZ J Surg | 2020 |
lobectomy |
| Depressive and/or anxiety scoring instruments used as screening tools for predicting postoperative delirium after cardiac surgery: A pilot study | Falk, A. Eriksson, M. Stenman, M. | Intensive Crit Care Nurs | 2020 |
Cardiac surgery |
| Preoperative Depression and Plasma Cortisol Levels as Predictors of Delirium after Cardiac Surgery | Eshmawey, M. Arlt, S. Ledschbor-Frahnert, C. Guenther, U. Popp, J. | Dementia and Geriatric Cognitive Disorders | 2020 |
hydrocortisone |
| Dexmedetomidine versus nalbuphine in prevention of emergence agitation following adenotonsillectomy in pediatrics | Elagamy, A. E. Mahran, M. G. Mahmoud, A. Z. | Egyptian Journal of Anaesthesia | 2020 |
NCT04058899 |
| Predicting Intense Levels of Child Anxiety During Anesthesia Induction at Hospital Arrival | Eijlers, R. Staals, L. M. Legerstee, J. S. Berghmans, J. M. Strabbing, E. M. van der Schroeff, M. P. Wijnen, R. M. H. Kind, L. S. Hillegers, M. H. J. Dierckx, B. Utens, Emwj | J Clin Psychol Med Settings | 2020 |
Anxiety |
| A systematic review and meta-analysis evaluating geriatric consultation on older trauma patients | Eagles, D. Godwin, B. Cheng, W. Moors, J. Figueira, S. Khoury, L. Fournier, K. Lampron, J. | J Trauma Acute Care Surg | 2020 | |
| Association between incident delirium and 28- and 90-day mortality in critically ill adults: a secondary analysis | Duprey, M. S. van den Boogaard, M. van der Hoeven, J. G. Pickkers, P. Briesacher, B. A. Saczynski, J. S. Griffith, J. L. Devlin, J. W. | Crit Care | 2020 |
Coma |
| Delirium in Meningitis and Encephalitis: Emergence and Prediction in a 6-Year Cohort | Dittrich, T. Marsch, S. Rüegg, S. De Marchis, G. M. Tschudin-Sutter, S. Sutter, R. | J Intensive Care Med | 2020 |
delirium |
| Neuropsychiatric aspects of COVID-19 pandemic: A selective review | Dinakaran, D. Manjunatha, N. Naveen Kumar, C. Suresh, B. M. | Asian J Psychiatr | 2020 |
Covid-19 |
| Psychometric properties of the intensive care delirium screening checklist when used by bedside nurses in clinical practice: a prospective descriptive study | Detroyer, E. Timmermans, A. Segers, D. Meyfroidt, G. Dubois, J. Van Assche, A. Joosten, E. Milisen, K. | BMC Nurs | 2020 |
Delirium |
| Delirium in a tertiary PICU: Risk factors and outcomes* | Dervan, L. A. Di Gennaro, J. L. Farris, R. W. D. Watson, R. S. | Pediatric Critical Care Medicine | 2020 |
age |
| Factors associated with ABCDE bundle adherence in critically ill adults requiring mechanical ventilation: An observational design | DeMellow, J. M. Kim, T. Y. Romano, P. S. Drake, C. Balas, M. C. | Intensive Crit Care Nurs | 2020 |
ABCDE bundle |
| Clinical practice in the management of postoperative delirium by Chinese anesthesiologists: a cross-sectional survey designed by the European Society of Anaesthesiology | Delp, S. Mei, W. Spies, C. D. Neuner, B. Aldecoa, C. Bettelli, G. Bilotta, F. Sanders, R. D. Kramer, S. Weiss, B. | J Int Med Res | 2020 |
China |
| Development of a Palliative Care Toolkit for the COVID-19 Pandemic | deLima Thomas, J. Leiter, R. E. Abrahm, J. L. Shameklis, J. C. Kiser, S. B. Gelfand, S. L. Sciacca, K. R. Reville, B. Siegert, C. A. Zhang, H. Lai, L. Sato, R. Smith, L. N. Kamdar, M. M. Greco, L. Lee, K. A. Tulsky, J. A. Lawton, A. J. | J Pain Symptom Manage | 2020 |
Covid-19 |
| Adherence to recommended practices for perioperative anesthesia care for older adults among US anesthesiologists: Results from the ASA Committee on Geriatric Anesthesia-Perioperative Brain Health Initiative ASA member survey | Deiner, S. Fleisher, L. A. Leung, J. M. Peden, C. Miller, T. Neuman, M. D. Neuman, M. D. Akhtar, S. Arora, S. Bentov, I. Bhandary, S. Brzezinski, M. Burstrom, R. E. Deiner, S. Evans, K. Leung, J. Lewis, M. C. Mahboobi, S. McSwain, J. Rooke, A. Whittington | Perioperative Medicine | 2020 |
aged |
| Evaluation of an Educational Intervention Utilizing Nurse "Champions" and Nurses' Documentation of Intensive Care Unit Delirium | DeForge, C. E. Yip, N. H. Dzierba, A. L. Ryan, P. G. Larson, E. L. | Dimens Crit Care Nurs | 2020 |
Cognitive interventions |
| Effect of early cognitive interventions on delirium in critically ill patients: a systematic review | Deemer, K. Zjadewicz, K. Fiest, K. Oviatt, S. Parsons, M. Myhre, B. Posadas-Calleja, J. | Can J Anaesth | 2020 |
Cognitive interventions |
| C-Reactive Protein and Procalcitonin Levels May Not Predict Delirium in Critically Ill Children | Dechnik, A. Mauer, E. A. Gerber, L. M. Traube, C. | Pediatr Crit Care Med | 2020 | |
| ‘Nonagenarians’ with a hip fracture: is a different orthogeriatric treatment strategy necessary? | de Groot, R. Nijmeijer, W. S. Folbert, E. C. Vollenbroek-Hutten, M. M. R. Hegeman, J. H. | Archives of Osteoporosis | 2020 |
cannulated screw |
| A quality improvement project for delirium prevention and management over the Greater Manchester Critical Care Network | Davis, J. Berry, K. McIntyre, R. Conway, D. Thomas, A. Hanison, J. | Journal of the Intensive Care Society | 2020 |
Delirium Critical Care Critical Illness Delirium Care Bundles Patient Care Bundles |
| Relationship Between Pain, Opioid Treatment, and Delirium in Older Emergency Department Patients | Daoust, R. Paquet, J. Boucher, V. Pelletier, M. Gouin, É Émond, M. | Acad Emerg Med | 2020 | |
| Impact of Early Reinitiation of Neuropsychiatric Medications on Agitation and Delirium in the Intensive Care Unit: A Retrospective Study | Cucci, M. D. Cunningham, B. S. Patel, J. S. Shimer, A. T. Mofleh, D. I. Mullen, C. L. | Ann Pharmacother | 2020 |
agitation |
| Valproic Acid for the Management of Agitation and Delirium in the Intensive Care Setting: A Retrospective Analysis | Crowley, K. E. Urben, L. Hacobian, G. Geiger, K. L. | Clin Ther | 2020 |
agitation |
| Multimodal Pain Management and Postoperative Outcomes in Lumbar Spine Fusion Surgery: A Population-based Cohort Study | Cozowicz, C. Bekeris, J. Poeran, J. Zubizarreta, N. Schwenk, E. Girardi, F. Memtsoudis, S. G. | Spine (Phila Pa 1976) | 2020 | |
| Systematic symptom and problem assessment at admission to the palliative care ward - Perspectives and prognostic impacts | Coym, A. Ullrich, A. Hackspiel, L. K. Ahrenholz, M. Bokemeyer, C. Oechsle, K. | BMC Palliative Care | 2020 |
adult |
| What are we asking for when requesting "Specialling" for the confused hospitalised older person? A concept analysis | Coyle, M. A. Wilson, V. Lapkin, S. Traynor, V. | Int J Older People Nurs | 2020 |
acute care |
| Delirium accompanies kidney dysfunction in hospitalized elderly patients | Coppolino, G. Castagna, A. Provenzano, M. Ruberto, C. Leonardi, G. Greco, L. Battaglia, G. G. Cerra, R. P. Andreucci, M. Bolignano, D. Ruotolo, G. | Journal of Gerontology and Geriatrics | 2020 |
low density lipoprotein cholesterol |
| An observational study of older patient specialling in acute hospital settings | Cook, J. Palesy, D. Lapkin, S. Chenoweth, L. | Int J Older People Nurs | 2020 |
acute hospital |
| Fundamental care for people with cognitive impairment in the hospital setting: A study combining positive organisational scholarship and video-reflexive ethnography | Collier, A. De Bellis, A. Hosie, A. Dadich, A. Symonds, T. Prendergast, J. Rodrigues, J. Bevan, A. | J Clin Nurs | 2020 |
Gait speed |
| Comparison of multidimensional frailty score, grip strength, and gait speed in older surgical patients | Choi, J. Y. Kim, K. I. Choi, Y. Ahn, S. H. Kang, E. Oh, H. K. Kim, D. W. Kim, E. K. Yoon, Y. S. Kang, S. B. Kim, H. H. Han, H. S. Kim, C. H. | J Cachexia Sarcopenia Muscle | 2020 |
Gait speed |
| Sleep Disturbance Strongly Related to the Development of Postoperative Delirium in Proximal Femoral Fracture Patients Aged 60 or Older | Cho, M. R. Song, S. K. Ryu, C. H. | Hip Pelvis | 2020 |
Delirium |
| Variation in the Management of Pain, Agitation, and Delirium in Intensive Care Units in British Columbia | Chiu, J. A. Shergill, M. Dhingra, V. Ronco, J. J. LeBlanc, A. Pamplin, C. McKeown, S. Dodek, P. M. | Am J Crit Care | 2020 | |
| Is hospitalisation a risk factor for cognitive decline in the elderly? | Chinnappa-Quinn, L. Bennett, M. Makkar, S. R. Kochan, N. A. Crawford, J. D. Sachdev, P. S. | Curr Opin Psychiatry | 2020 | |
| Clinical studies on the relationship of the short duration of use of midazolam with the occurrence of delirium in icu patients with mechanical ventilation | Chen, Z. F. | Farmacia | 2020 |
midazolam |
| Preoperative Circulating MiR-210, a Risk Factor for Postoperative Delirium among Elderly Patients with Gastric Cancer Undergoing Curative Resection | Chen, Y. Zheng, J. Chen, J. | Curr Pharm Des | 2020 |
Gastric cancer |
| The Incidence and Predictors of Postoperative Delirium After Brain Tumor Resection in Adults: A Cross-Sectional Survey | Chen, H. Jiang, H. Chen, B. Fan, L. Shi, W. Jin, Y. Ren, X. Lang, L. Zhu, F. | World Neurosurg | 2020 |
Delirium |
| Baclofen has a risk of encephalopathy in older adults receiving dialysis | Chauvin, K. J. Blake, P. G. Garg, A. X. Weir, M. A. Bathini, L. Dixon, S. N. McArthur, E. Sontrop, J. M. Moist, L. Kim, R. B. Muanda, F. T. | Kidney Int | 2020 |
baclofen |
| Delirium Among Hospitalized Older Adults in Thailand: An Integrative Review | Chang, H. C. R. Neal, K. Traynor, V. Ho, M. H. Kankom, W. | J Gerontol Nurs | 2020 | |
| American Society for Enhanced Recovery and Perioperative quality initiative joint consensus statement on the role of neuromonitoring in perioperative outcomes: Electroencephalography | Chan, M. T. V. Hedrick, T. L. Egan, T. D. García, P. S. Koch, S. Purdon, P. L. Ramsay, M. A. Miller, T. E. McEvoy, M. D. Gan, T. J. Hughes, C. G. Boncyk, C. S. Culley, D. J. Fleisher, L. A. Leung, J. M. McDonagh, D. L. Thiele, R. H. Shaw, A. Bartels, K. | Anesthesia and Analgesia | 2020 |
anesthesiologist |
| Evidence-based clinical practice guidelines for the management of sedoanalgesia and delirium in critically ill adult patients | Celis-Rodríguez, E. Díaz Cortés, J. C. Cárdenas Bolívar, Y. R. Carrizosa González, J. A. Pinilla, D. I. Ferrer Záccaro, L. E. Birchenall, C. Caballero López, J. Argüello, B. M. Castillo Abrego, G. Castorena Arellano, G. Dueñas Castell, C. Jáure | Med Intensiva | 2020 |
Agitación |
| Patient care during the COVID-19 pandemic: do not leave delirium behind | Castro, R. E. V. Garcez, F. B. Avelino-Silva, T. J. | Braz J Psychiatry | 2020 | |
| The financial and social costs of delirium | Caplan, G. A. Teodorczuk, A. Streatfeild, J. Agar, M. R. | European Geriatric Medicine | 2020 |
cost control |
| Clinical impression for identification of vulnerable older patients in the emergency department | Calf, A. H. Lubbers, S. van den Berg, A. A. van den Berg, E. Jansen, C. J. van Munster, B. C. de Rooij, S. E. Ter Maaten, J. C. | Eur J Emerg Med | 2020 | |
| Is Delirium Pediatric Confusion Assessment Method Tools Confiable? | Caino de Oliveira, F. R. Ribeiro de Araujo, O. Brunow de Carvalho, W. | Pediatr Crit Care Med | 2020 |
Brazil |
| Research in brief: Inpatient hip fractures and nomenclature of delirium and acute encephalopathy | Cacciottolo, T. M. Ferrigan, L. | Clin Med (Lond) | 2020 | |
| Prolonged Confusional state as first manifestation of COVID-19 | Butt, I. Sawlani, V. Geberhiwot, T. | Ann Clin Transl Neurol | 2020 |
Covid-19 |
| Delirium After Withdrawal From Valerian Root: A Case Report | Burke, H. Jiang, S. Chatham, P. Stern, T. A. | Psychosomatics | 2020 | |
| Deciphering delirium through semantics: a selective synopsis | Bugiani, O. | Neurol Sci | 2020 |
Ageing |
| Predicting incident delirium diagnoses using data from primary-care electronic health records | Bowman, K. Jones, L. Masoli, J. Mujica-Mota, R. Strain, D. Butchart, J. Valderas, J. M. Fortinsky, R. H. Melzer, D. Delgado, J. | Age Ageing | 2020 |
at home |
| Comparison of Self-Reported and Behavioral Pain Assessment Tools in Critically Ill Patients | Bouajram, R. H. Sebat, C. M. Love, D. Louie, E. L. Wilson, M. D. Duby, J. J. | J Intensive Care Med | 2020 |
Behavioral Pain Scale |
| Practical Training of Anesthesia Clinicians in Electroencephalogram-Based Determination of Hypnotic Depth of General Anesthesia | Bombardieri, A. M. Wildes, T. S. Stevens, T. Wolfson, M. Steinhorn, R. Ben Abdallah, A. Sleigh, J. Avidan, M. S. | Anesth Analg | 2020 |
Anesthesia, Inhalation |
| A multisite study of nurse-reported perceptions and practice of ABCDEF bundle components | Boehm, L. M. Pun, B. T. Stollings, J. L. Girard, T. D. Rock, P. Hough, C. L. Hsieh, S. J. Khan, B. A. Owens, R. L. Schmidt, G. A. Smith, S. Ely, E. W. | Intensive Crit Care Nurs | 2020 |
ABCDEF bundle |
| Cognitive impairment, clinical symptoms and functional disability in patients emerging from the minimally conscious state | Bodien, Y. G. Martens, G. Ostrow, J. Sheau, K. Giacino, J. T. | NeuroRehabilitation | 2020 |
adult |
| Effect of intravenous iron on functional outcomes in hip fracture: a randomised controlled trial | Bielza, R. Llorente, J. Thuissard, I. J. Andreu-Vázquez, C. Blanco, D. Sanjurjo, J. López, N. Herráez, M. R. Molano, C. Morales, A. Arias, E. Neira, M. Lung, A. Escalera, J. Portillo, L. Larrubia, Y. García, C. Zambrana, F. Gómez Cerezo, J. | Age Ageing | 2020 |
anaemia |
| Tapering with Pharmaceutical GHB or Benzodiazepines for Detoxification in GHB-Dependent Patients: A Matched-Subject Observational Study of Treatment-as-Usual in Belgium and The Netherlands | Beurmanjer, H. Luykx, J. J. De Wilde, B. van Rompaey, K. Buwalda, V. J. A. De Jong, C. A. J. Dijkstra, B. A. G. Schellekens, A. F. A. | CNS Drugs | 2020 | |
| Clinical characteristics and outcomes of inpatients with neurologic disease and COVID-19 in Brescia, Lombardy, Italy | Benussi, A. Pilotto, A. Premi, E. Libri, I. Giunta, M. Agosti, C. Alberici, A. Baldelli, E. Benini, M. Bonacina, S. Brambilla, L. Caratozzolo, S. Cortinovis, M. Costa, A. Piccinelli, S. C. Cottini, E. Cristillo, V. Delrio, I. Filosto, M. Gamba, M. Gazzina | Neurology | 2020 | |
| Palliative sedation: beliefs and decision-making among Spanish palliative care physicians | Benítez-Rosario, M. A. Ascanio-León, B. | Support Care Cancer | 2020 |
Cancer patients |
| A Tunisian version of the confusion assessment method for the intensive care unit (CAM-ICU): translation and validation | Ben Saida, I. Kortli, S. Amamou, B. Kacem, N. Ghardallou, M. Ely, E. W. Ben Saad, H. Boussarsar, M. | BMC Psychiatry | 2020 |
Critical illness |
| 'Socialised care futility' in the care of older people in hospital who call out repetitively: An ethnographic study | Beaver, J. Goldberg, S. E. Edgley, A. Harwood, R. H. | Int J Nurs Stud | 2020 |
Acute hospitals |
| Delirium in COVID-19: A case series and exploration of potential mechanisms for central nervous system involvement | Beach, S. R. Praschan, N. C. Hogan, C. Dotson, S. Merideth, F. Kontos, N. Fricchione, G. L. Smith, F. A. | Gen Hosp Psychiatry | 2020 |
Akinetic mutism |
| Prevalence of delirium in intensive care patients and association with sedoanalgesia, severity and mortality | Bastos, A. S. Beccaria, L. M. Silva, D. C. D. Barbosa, T. P. | Revista gaucha de enfermagem | 2020 |
adult |
| Antipsychotics and the Risk of Mortality or Cardiopulmonary Arrest in Hospitalized Adults | Basciotta, M. Zhou, W. Ngo, L. Donnino, M. Marcantonio, E. R. Herzig, S. J. | J Am Geriatr Soc | 2020 |
antipsychotics |
| Comprehensive analysis of in-hospital delirium after major surgical oncology procedures: A population-based study | Bandini, M. Marchioni, M. Preisser, F. Nazzani, S. Tian, Z. Graefen, M. Montorsi, F. Saad, F. Shariat, S. F. Schips, L. Briganti, A. Karakiewicz, P. I. | Can Urol Assoc J | 2020 |
adult |
| Sepsis Associated Delirium | Atterton, B. Paulino, M. C. Povoa, P. Martin-Loeches, I. | Medicina (Kaunas) | 2020 |
adult |
| Melatonin for delirium prevention in acute medically ill, and perioperative geriatric patients | Asleson, D. R. Chiu, A. W. | Aging Medicine | 2020 |
adult |
| The short- And long-term outcomes of esophagectomy for esophageal cancer in patients older than 75 years | Aoyama, T. Hara, K. Kazama, K. Atsumi, Y. Tamagawa, H. Tamagawa, A. MacHida, D. Komori, K. Maezawa, Y. Kano, K. Hashimoto, I. Oshima, T. Murakawa, M. Numata, M. Yukawa, N. Masuda, M. Rino, Y. | Anticancer Research | 2020 |
antineoplastic agent |
| National French survey of COVID-19 symptoms in people aged 70 and over | Annweiler, C. Sacco, G. Salles, N. Aquino, J. P. Gautier, J. Berrut, G. Guérin, O. Gavazzi, G. | Clin Infect Dis | 2020 | |
| COVID-19: ICU delirium management during SARS-CoV-2 pandemic-pharmacological considerations | Andrews, L. J. Benken, S. T. | Crit Care | 2020 |
Betacoronavirus |
| The Intersection of Architecture/Medicine/Quality and the Clinical Nurse Specialist: Designing for the Prevention of Delirium | Anderson, D. C. Jacoby, S. R. Scruth, E. A. | Clinical nurse specialist CNS | 2020 | |
| The Agents Intervening against Delirium in the Intensive Care Unit-Trial (AID-ICU trial):- a detailed statistical analysis plan | Andersen-Ranberg, N. Poulsen, L. M. Perner, A. Wetterslev, J. Mathiesen, O. Mortensen, C. B. Estrup, S. Ebdrup, B. H. Hästbacka, J. Citerio, G. Caballero, J. Morgan, M. P. G. Oxenbøll-Collet, M. Weber, S. O. Andreasen, A. S. Bestle, M. H. Pedersen, H. B | Acta Anaesthesiol Scand | 2020 | |
| A systematic review of the overlap of fluid biomarkers in delirium and advanced cancer-related syndromes | Amgarth-Duff, I. Hosie, A. Caplan, G. Agar, M. | BMC Psychiatry | 2020 |
Advanced cancer |
| Toward best practice methods for delirium biomarker studies: An international modified Delphi study | Amgarth-Duff, I. Hosie, A. Caplan, G. Agar, M. | Int J Geriatr Psychiatry | 2020 |
consensus |
| Preoperative cognitive dysfunction in older elective noncardiac surgical patients in South Africa | Amado, L. A. Perrie, H. Scribante, J. Ben-Israel, K. A. | Br J Anaesth | 2020 |
Mini-Cog |
| The etiology and age-related properties of patients with delirium in coronary intensive care unit and its effects on inhospital and follow up prognosis | Altay, S. Gürdoğan, M. Kaya, Ç Kardaş, F. Zeybey, U. Çakir, B. Ebik, M. Demir, M. | Ideggyogy Sz | 2020 |
delirium in coronary intensive care unit |