What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| The Validity and Reliability of the Japanese Version of the Cornell Assessment of Pediatric Delirium | Hoshino, H. Matsuishi, Y. Enomoto, Y. Shimojo, N. Kido, T. Matsuzaki, A. Matsubara, M. Kato, H. Hoshino, T. Traube, C. Silver, G. Kawano, S. Inoue, Y. | Pediatr Crit Care Med | 2020 | |
| The incidence and predictors of postoperative delirium (POD) after brain tumor resection in adults: A cross-sectional survey | Hong Chen, M. N. Jiang, H. Chen, B. Fan, L. Shi, W. Jin, Y. Ren, X. Lang, L. Zhu, F. | World neurosurgery | 2020 |
adult |
| A Systematic Review of Risk Factors for Sleep Disruption in Critically Ill Adults | Honarmand, K. Rafay, H. Le, J. Mohan, S. Rochwerg, B. Devlin, J. W. Skrobik, Y. Weinhouse, G. L. Drouot, X. Watson, P. L. McKinley, S. Bosma, K. J. | Critical care medicine | 2020 |
adult |
| Neurotoxicity in chronic lithium poisoning | Hlaing, P. M. Isoardi, K. Z. Page, C. B. Pillans, P. | Intern Med J | 2020 |
chronic poisoning |
| Postoperative delirium in patients undergoing surgery for bone metastases | Hindiskere, S. Kim, H. S. Han, I. | Medicine (Baltimore) | 2020 |
Aged |
| Delirium in patients of the Intensive Care Unit of a health institution in Montería, Colombia | Herrera Herrera, J. L. Oyola López, E. Llorente Pérez, Y. J. | Revista Cientifica de la Sociedad Espanola de Enfermeria Neurologica | 2020 |
adult |
| Total Hip Arthroplasty in Patients With Dementia | Hernandez, N. M. Cunningham, D. J. Jiranek, W. A. Bolognesi, M. P. Seyler, T. M. | J Arthroplasty | 2020 |
complications |
| Neurologic Features in Severe SARS-CoV-2 Infection | Helms, J. Kremer, S. Merdji, H. Clere-Jehl, R. Schenck, M. Kummerlen, C. Collange, O. Boulay, C. Fafi-Kremer, S. Ohana, M. Anheim, M. Meziani, F. | N Engl J Med | 2020 |
Adult |
| Association between delirium prediction scores and days spent with delirium | Heesakkers, H. Devlin, J. W. Slooter, A. J. C. van den Boogaard, M. | J Crit Care | 2020 |
Critical illness |
| Association of Hypoactive and Hyperactive Delirium With Cognitive Function After Critical Illness | Hayhurst, C. J. Marra, A. Han, J. H. Patel, M. B. Brummel, N. E. Thompson, J. L. Jackson, J. C. Chandrasekhar, R. Ely, E. W. Pandharipande, P. P. Hughes, C. G. | Crit Care Med | 2020 | |
| Mental disorders of geriatric inpatients: symptom characteristics and treatment outcome | Haupt, M. Jänner, M. Richert, F. | Int Psychogeriatr | 2020 |
clinical symptomatology |
| Video Glasses Reduce Preoperative Anxiety Compared With Portable Multimedia Player in Children: A Randomized Controlled Trial | Hashimoto, Y. Chaki, T. Hirata, N. Tokinaga, Y. Yoshikawa, Y. Yamakage, M. | J Perianesth Nurs | 2020 |
anesthesia |
| Assessing Risks of Polypharmacy Involving Medications With Anticholinergic Properties | Hanlon, P. Quinn, T. J. Gallacher, K. I. Myint, P. K. Jani, B. D. Nicholl, B. I. Lowrie, R. Soiza, R. L. Neal, S. R. Lee, D. Mair, F. S. | Ann Fam Med | 2020 |
anticholinergic burden |
| Melatonin and its analogues for the prevention of postoperative delirium: A systematic review and meta-analysis | Han, Y. Wu, J. Qin, Z. Fu, W. Zhao, B. Li, X. Wang, W. Sha, T. Sun, M. Li, J. Zeng, Z. Chen, Z. | J Pineal Res | 2020 |
melatonin |
| Proteomic Analysis of Preoperative CSF Reveals Risk Biomarkers of Postoperative Delirium | Han, Y. Chen, W. Song, Y. Yuan, Y. Li, Z. Zhou, Y. Liu, T. Han, D. Mi, X. Li, M. Wang, G. Zhong, L. Zhou, J. Guo, X. | Front Psychiatry | 2020 |
cerebrospinal fluid |
| Inpatient gastrostomy in Huntington's disease: Nationwide analysis of utilization and outcomes compared to amyotrophic lateral sclerosis | Hamedani, A. G. Pauly, M. Thibault, D. P. Gonzalez-Alegre, P. Willis, A. W. | Clinical Parkinsonism and Related Disorders | 2020 |
Huntington’s disease Health services research Outcome research Gastrostomy |
| The Observational Scale of Level of Arousal: A brief tool for assessing and monitoring level of arousal in patients with delirium outside the ICU | Hall, R. Stíobhairt, A. Allerhand, M. MacLullich, A. M. J. Tieges, Z. | Int J Geriatr Psychiatry | 2020 |
arousal |
| Development of disturbance of consciousness is associated with increased severity in acute pancreatitis | Hágendorn, R. Vincze, Á Izbéki, F. Gajdán, L. Gódi, S. Illés, A. Sarlós, P. Farkas, N. Erőss, B. Lillik, V. Illés, D. Varjú, P. Márta, K. Török, I. Papp, M. Vitális, Z. Bod, B. Hamvas, J. Szepes, Z. Takács, T. Czakó, L. Márton, Z. Szentes | Pancreatology | 2020 |
Acute pancreatitis |
| Prophylactic Physostigmine for Extreme and Refractory Adult Emergence Delirium, Aimed at Increasing Patient Safety and Reducing Health Care Workplace Violence: A Case Report | Gutman, D. A. Hassid, M. Jeanes, Z. Redding, A. T. Romeo, D. | A and A Practice | 2020 |
adult |
| No Brain Is an Island | Guay, C. S. Avidan, M. S. | Anesth Analg | 2020 |
Brain |
| The role of physical exercise and rehabilitation in delirium | Gual, N. García-Salmones, M. Brítez, L. Crespo, N. Udina, C. Pérez, L. M. Inzitari, M. | European Geriatric Medicine | 2020 |
brain function |
| The incidence of prolonged post-electroconvulsive therapy delirium: A retrospective study | Grover, S. Kumar, A. Chakrabarti, S. Avasthi, A. | Indian J Psychiatry | 2020 |
Electroconvulsive therapy |
| Postoperative Delirium in Patients after Hip Fracture Tratment Postoperative Delirium in Patients after Hip Fracture Tratment | Grle, M. Markotić, V. Prlić, J. Grle, I. Miljko, M. | Psychiatr Danub | 2020 | |
| Intensive Care Unit Delirium, Clinical Observations, and Patients' Statements: A Case Study | Granberg-Axèll, A. Bergbom, I. | Dimensions of critical care nursing : DCCN | 2020 |
adult |
| Assessment of the Decision-Making Capacity for Clinical Research Participation in Patients With Advanced Cancer in the Last Weeks of Life | Goswami, R. Moore, J. Bruera, E. Hui, D. | Journal of Pain and Symptom Management | 2020 |
adult |
| Reducing Delirium in Hospitalized Adults Through a Structured Sleep Promotion Program | Gode, A. Kozub, E. Joerger, K. Lynch, C. Roche, M. Kirven, J. | J Nurs Care Qual | 2020 | |
| Preoperative Cognitive Assessment Recommendations for the Older Adult | Glover, N. P. Tola, D. H. Norcross, W. Naumuk, L. Tocchi, C. | J Perianesth Nurs | 2020 |
Mini-Cog |
| Use of Direct In-Person Observation in the Care of Hospitalized Older Adults with Cognitive Impairment: A Systematic Review | Gilmore-Bykovskyi, A. L. Fuhr, H. Jin, Y. Benson, C. | J Gerontol Nurs | 2020 | |
| The consistent burden in published estimates of delirium occurrence in medical inpatients over four decades: a systematic review and meta-analysis study | Gibb, K. Seeley, A. Quinn, T. Siddiqi, N. Shenkin, S. Rockwood, K. Davis, D. | Age Ageing | 2020 |
delirium |
| Loss of Independence in Older Patients after Operation for Colorectal Cancer | Gearhart, S. L. Do, E. M. Owodunni, O. Gabre-Kidan, A. A. Magnuson, T. | J Am Coll Surg | 2020 | |
| Time to Block: Early Regional Anesthesia Improves Pain Control in Geriatric Hip Fractures | Garlich, J. M. Pujari, A. Debbi, E. M. Yalamanchili, D. R. Moak, Z. B. Stephenson, S. K. Stephan, S. R. Polakof, L. S. Johnson, C. R. Noorzad, A. S. Little, M. T. M. Moon, C. N. Black, J. T. Anand, K. K. Lin, C. A. | J Bone Joint Surg Am | 2020 |
Brain |
| Encephalopathy in patients with COVID-19: A review | Garg, R. K. Paliwal, V. K. Gupta, A. | J Med Virol | 2020 |
Brain |
| Prevalence and risk factors of postoperative delirium after spinal surgery: a meta-analysis | Gao, H. Ma, H. J. Li, Y. J. Yin, C. Li, Z. | J Orthop Surg Res | 2020 |
Delirium |
| Prognostic factors for discharge to home and residing at home 12 months after hip fracture: an Anoia hip study | Gamboa-Arango, A. Duaso, E. Malafarina, V. Formiga, F. Marimón, P. Sandiumenge, M. Salgado, M. T. Escalante, E. Lumbreras, C. Tarrida, A. | Aging Clinical and Experimental Research | 2020 |
aged |
| Safety of the muscarinic receptor-antagonist (R,R)-penehyclidine fumarate in healthy subjects: A phase 1 randomized, double-blind, single-dose escalation study | Fu, C. Zhang, X. Pei, Q. Guo, C. Yang, X. Yang, S. Huang, J. Yang, G. | Int J Clin Pharmacol Ther | 2020 |
Administration, Oral |
| Discriminant Performance of Dysexecutive and Frontal Release Signs for Delirium in Patients With High Dementia Prevalence: Implications for Neural Network Impairment | Franco, J. G. Trzepacz, P. T. Velásquez-Tirado, J. D. Ocampo, M. V. Serna, P. A. Giraldo, A. M. López, C. Zuluaga, A. Zaraza-Morales, D. | Psychosomatics | 2020 |
abnormal reflex |
| Survey of psychiatrists and psychiatry residents in Colombia about their preventive and therapeutic practices in delirium | Franco, J. G. Oviedo Lugo, G. F. Patarroyo Rodriguez, L. Bernal Miranda, J. Molano, J. C. Rojas Moreno, M. Cardeño, C. Velasquez Tirado, J. D. | Revista Colombiana de Psiquiatria | 2020 |
Antipsychotics Delirium Health education Primary prevention Quality of healthcare Therapeutics |
| Adverse Events, Functional Decline, and Access to Allied Health Therapies for Patients With Dementia During Acute Hospitalization | Fox, A. MacAndrew, M. Wyles, K. Yelland, C. Beattie, E. | J Appl Gerontol | 2020 |
acute care |
| Outcomes of video-assisted thoracoscopic surgery lobectomy in septuagenarians | Fong, L. S. Ko, V. McLaughlin, A. Okiwelu, N. L. Newman, M. A. Passage, J. Sanders, L. H. A. Joshi, P. V. | ANZ J Surg | 2020 |
lobectomy |
| Depressive and/or anxiety scoring instruments used as screening tools for predicting postoperative delirium after cardiac surgery: A pilot study | Falk, A. Eriksson, M. Stenman, M. | Intensive Crit Care Nurs | 2020 |
Cardiac surgery |
| Preoperative Depression and Plasma Cortisol Levels as Predictors of Delirium after Cardiac Surgery | Eshmawey, M. Arlt, S. Ledschbor-Frahnert, C. Guenther, U. Popp, J. | Dementia and Geriatric Cognitive Disorders | 2020 |
hydrocortisone |
| Dexmedetomidine versus nalbuphine in prevention of emergence agitation following adenotonsillectomy in pediatrics | Elagamy, A. E. Mahran, M. G. Mahmoud, A. Z. | Egyptian Journal of Anaesthesia | 2020 |
NCT04058899 |
| Predicting Intense Levels of Child Anxiety During Anesthesia Induction at Hospital Arrival | Eijlers, R. Staals, L. M. Legerstee, J. S. Berghmans, J. M. Strabbing, E. M. van der Schroeff, M. P. Wijnen, R. M. H. Kind, L. S. Hillegers, M. H. J. Dierckx, B. Utens, Emwj | J Clin Psychol Med Settings | 2020 |
Anxiety |
| A systematic review and meta-analysis evaluating geriatric consultation on older trauma patients | Eagles, D. Godwin, B. Cheng, W. Moors, J. Figueira, S. Khoury, L. Fournier, K. Lampron, J. | J Trauma Acute Care Surg | 2020 | |
| Association between incident delirium and 28- and 90-day mortality in critically ill adults: a secondary analysis | Duprey, M. S. van den Boogaard, M. van der Hoeven, J. G. Pickkers, P. Briesacher, B. A. Saczynski, J. S. Griffith, J. L. Devlin, J. W. | Crit Care | 2020 |
Coma |
| Delirium in Meningitis and Encephalitis: Emergence and Prediction in a 6-Year Cohort | Dittrich, T. Marsch, S. Rüegg, S. De Marchis, G. M. Tschudin-Sutter, S. Sutter, R. | J Intensive Care Med | 2020 |
delirium |
| Neuropsychiatric aspects of COVID-19 pandemic: A selective review | Dinakaran, D. Manjunatha, N. Naveen Kumar, C. Suresh, B. M. | Asian J Psychiatr | 2020 |
Covid-19 |
| Psychometric properties of the intensive care delirium screening checklist when used by bedside nurses in clinical practice: a prospective descriptive study | Detroyer, E. Timmermans, A. Segers, D. Meyfroidt, G. Dubois, J. Van Assche, A. Joosten, E. Milisen, K. | BMC Nurs | 2020 |
Delirium |
| Delirium in a tertiary PICU: Risk factors and outcomes* | Dervan, L. A. Di Gennaro, J. L. Farris, R. W. D. Watson, R. S. | Pediatric Critical Care Medicine | 2020 |
age |
| Factors associated with ABCDE bundle adherence in critically ill adults requiring mechanical ventilation: An observational design | DeMellow, J. M. Kim, T. Y. Romano, P. S. Drake, C. Balas, M. C. | Intensive Crit Care Nurs | 2020 |
ABCDE bundle |
| Clinical practice in the management of postoperative delirium by Chinese anesthesiologists: a cross-sectional survey designed by the European Society of Anaesthesiology | Delp, S. Mei, W. Spies, C. D. Neuner, B. Aldecoa, C. Bettelli, G. Bilotta, F. Sanders, R. D. Kramer, S. Weiss, B. | J Int Med Res | 2020 |
China |
| Development of a Palliative Care Toolkit for the COVID-19 Pandemic | deLima Thomas, J. Leiter, R. E. Abrahm, J. L. Shameklis, J. C. Kiser, S. B. Gelfand, S. L. Sciacca, K. R. Reville, B. Siegert, C. A. Zhang, H. Lai, L. Sato, R. Smith, L. N. Kamdar, M. M. Greco, L. Lee, K. A. Tulsky, J. A. Lawton, A. J. | J Pain Symptom Manage | 2020 |
Covid-19 |
| Adherence to recommended practices for perioperative anesthesia care for older adults among US anesthesiologists: Results from the ASA Committee on Geriatric Anesthesia-Perioperative Brain Health Initiative ASA member survey | Deiner, S. Fleisher, L. A. Leung, J. M. Peden, C. Miller, T. Neuman, M. D. Neuman, M. D. Akhtar, S. Arora, S. Bentov, I. Bhandary, S. Brzezinski, M. Burstrom, R. E. Deiner, S. Evans, K. Leung, J. Lewis, M. C. Mahboobi, S. McSwain, J. Rooke, A. Whittington | Perioperative Medicine | 2020 |
aged |
| Evaluation of an Educational Intervention Utilizing Nurse "Champions" and Nurses' Documentation of Intensive Care Unit Delirium | DeForge, C. E. Yip, N. H. Dzierba, A. L. Ryan, P. G. Larson, E. L. | Dimens Crit Care Nurs | 2020 |
Cognitive interventions |
| Effect of early cognitive interventions on delirium in critically ill patients: a systematic review | Deemer, K. Zjadewicz, K. Fiest, K. Oviatt, S. Parsons, M. Myhre, B. Posadas-Calleja, J. | Can J Anaesth | 2020 |
Cognitive interventions |
| C-Reactive Protein and Procalcitonin Levels May Not Predict Delirium in Critically Ill Children | Dechnik, A. Mauer, E. A. Gerber, L. M. Traube, C. | Pediatr Crit Care Med | 2020 | |
| ‘Nonagenarians’ with a hip fracture: is a different orthogeriatric treatment strategy necessary? | de Groot, R. Nijmeijer, W. S. Folbert, E. C. Vollenbroek-Hutten, M. M. R. Hegeman, J. H. | Archives of Osteoporosis | 2020 |
cannulated screw |
| A quality improvement project for delirium prevention and management over the Greater Manchester Critical Care Network | Davis, J. Berry, K. McIntyre, R. Conway, D. Thomas, A. Hanison, J. | Journal of the Intensive Care Society | 2020 |
Delirium Critical Care Critical Illness Delirium Care Bundles Patient Care Bundles |
| Relationship Between Pain, Opioid Treatment, and Delirium in Older Emergency Department Patients | Daoust, R. Paquet, J. Boucher, V. Pelletier, M. Gouin, É Émond, M. | Acad Emerg Med | 2020 | |
| Impact of Early Reinitiation of Neuropsychiatric Medications on Agitation and Delirium in the Intensive Care Unit: A Retrospective Study | Cucci, M. D. Cunningham, B. S. Patel, J. S. Shimer, A. T. Mofleh, D. I. Mullen, C. L. | Ann Pharmacother | 2020 |
agitation |
| Valproic Acid for the Management of Agitation and Delirium in the Intensive Care Setting: A Retrospective Analysis | Crowley, K. E. Urben, L. Hacobian, G. Geiger, K. L. | Clin Ther | 2020 |
agitation |
| Multimodal Pain Management and Postoperative Outcomes in Lumbar Spine Fusion Surgery: A Population-based Cohort Study | Cozowicz, C. Bekeris, J. Poeran, J. Zubizarreta, N. Schwenk, E. Girardi, F. Memtsoudis, S. G. | Spine (Phila Pa 1976) | 2020 | |
| Systematic symptom and problem assessment at admission to the palliative care ward - Perspectives and prognostic impacts | Coym, A. Ullrich, A. Hackspiel, L. K. Ahrenholz, M. Bokemeyer, C. Oechsle, K. | BMC Palliative Care | 2020 |
adult |
| What are we asking for when requesting "Specialling" for the confused hospitalised older person? A concept analysis | Coyle, M. A. Wilson, V. Lapkin, S. Traynor, V. | Int J Older People Nurs | 2020 |
acute care |
| Delirium accompanies kidney dysfunction in hospitalized elderly patients | Coppolino, G. Castagna, A. Provenzano, M. Ruberto, C. Leonardi, G. Greco, L. Battaglia, G. G. Cerra, R. P. Andreucci, M. Bolignano, D. Ruotolo, G. | Journal of Gerontology and Geriatrics | 2020 |
low density lipoprotein cholesterol |
| An observational study of older patient specialling in acute hospital settings | Cook, J. Palesy, D. Lapkin, S. Chenoweth, L. | Int J Older People Nurs | 2020 |
acute hospital |
| Fundamental care for people with cognitive impairment in the hospital setting: A study combining positive organisational scholarship and video-reflexive ethnography | Collier, A. De Bellis, A. Hosie, A. Dadich, A. Symonds, T. Prendergast, J. Rodrigues, J. Bevan, A. | J Clin Nurs | 2020 |
Gait speed |
| Comparison of multidimensional frailty score, grip strength, and gait speed in older surgical patients | Choi, J. Y. Kim, K. I. Choi, Y. Ahn, S. H. Kang, E. Oh, H. K. Kim, D. W. Kim, E. K. Yoon, Y. S. Kang, S. B. Kim, H. H. Han, H. S. Kim, C. H. | J Cachexia Sarcopenia Muscle | 2020 |
Gait speed |
| Sleep Disturbance Strongly Related to the Development of Postoperative Delirium in Proximal Femoral Fracture Patients Aged 60 or Older | Cho, M. R. Song, S. K. Ryu, C. H. | Hip Pelvis | 2020 |
Delirium |
| Variation in the Management of Pain, Agitation, and Delirium in Intensive Care Units in British Columbia | Chiu, J. A. Shergill, M. Dhingra, V. Ronco, J. J. LeBlanc, A. Pamplin, C. McKeown, S. Dodek, P. M. | Am J Crit Care | 2020 | |
| Is hospitalisation a risk factor for cognitive decline in the elderly? | Chinnappa-Quinn, L. Bennett, M. Makkar, S. R. Kochan, N. A. Crawford, J. D. Sachdev, P. S. | Curr Opin Psychiatry | 2020 | |
| Clinical studies on the relationship of the short duration of use of midazolam with the occurrence of delirium in icu patients with mechanical ventilation | Chen, Z. F. | Farmacia | 2020 |
midazolam |
| Preoperative Circulating MiR-210, a Risk Factor for Postoperative Delirium among Elderly Patients with Gastric Cancer Undergoing Curative Resection | Chen, Y. Zheng, J. Chen, J. | Curr Pharm Des | 2020 |
Gastric cancer |
| The Incidence and Predictors of Postoperative Delirium After Brain Tumor Resection in Adults: A Cross-Sectional Survey | Chen, H. Jiang, H. Chen, B. Fan, L. Shi, W. Jin, Y. Ren, X. Lang, L. Zhu, F. | World Neurosurg | 2020 |
Delirium |
| Baclofen has a risk of encephalopathy in older adults receiving dialysis | Chauvin, K. J. Blake, P. G. Garg, A. X. Weir, M. A. Bathini, L. Dixon, S. N. McArthur, E. Sontrop, J. M. Moist, L. Kim, R. B. Muanda, F. T. | Kidney Int | 2020 |
baclofen |
| Delirium Among Hospitalized Older Adults in Thailand: An Integrative Review | Chang, H. C. R. Neal, K. Traynor, V. Ho, M. H. Kankom, W. | J Gerontol Nurs | 2020 | |
| American Society for Enhanced Recovery and Perioperative quality initiative joint consensus statement on the role of neuromonitoring in perioperative outcomes: Electroencephalography | Chan, M. T. V. Hedrick, T. L. Egan, T. D. García, P. S. Koch, S. Purdon, P. L. Ramsay, M. A. Miller, T. E. McEvoy, M. D. Gan, T. J. Hughes, C. G. Boncyk, C. S. Culley, D. J. Fleisher, L. A. Leung, J. M. McDonagh, D. L. Thiele, R. H. Shaw, A. Bartels, K. | Anesthesia and Analgesia | 2020 |
anesthesiologist |
| Evidence-based clinical practice guidelines for the management of sedoanalgesia and delirium in critically ill adult patients | Celis-Rodríguez, E. Díaz Cortés, J. C. Cárdenas Bolívar, Y. R. Carrizosa González, J. A. Pinilla, D. I. Ferrer Záccaro, L. E. Birchenall, C. Caballero López, J. Argüello, B. M. Castillo Abrego, G. Castorena Arellano, G. Dueñas Castell, C. Jáure | Med Intensiva | 2020 |
Agitación |
| Patient care during the COVID-19 pandemic: do not leave delirium behind | Castro, R. E. V. Garcez, F. B. Avelino-Silva, T. J. | Braz J Psychiatry | 2020 | |
| The financial and social costs of delirium | Caplan, G. A. Teodorczuk, A. Streatfeild, J. Agar, M. R. | European Geriatric Medicine | 2020 |
cost control |
| Clinical impression for identification of vulnerable older patients in the emergency department | Calf, A. H. Lubbers, S. van den Berg, A. A. van den Berg, E. Jansen, C. J. van Munster, B. C. de Rooij, S. E. Ter Maaten, J. C. | Eur J Emerg Med | 2020 | |
| Is Delirium Pediatric Confusion Assessment Method Tools Confiable? | Caino de Oliveira, F. R. Ribeiro de Araujo, O. Brunow de Carvalho, W. | Pediatr Crit Care Med | 2020 |
Brazil |
| Research in brief: Inpatient hip fractures and nomenclature of delirium and acute encephalopathy | Cacciottolo, T. M. Ferrigan, L. | Clin Med (Lond) | 2020 | |
| Prolonged Confusional state as first manifestation of COVID-19 | Butt, I. Sawlani, V. Geberhiwot, T. | Ann Clin Transl Neurol | 2020 |
Covid-19 |
| Delirium After Withdrawal From Valerian Root: A Case Report | Burke, H. Jiang, S. Chatham, P. Stern, T. A. | Psychosomatics | 2020 | |
| Deciphering delirium through semantics: a selective synopsis | Bugiani, O. | Neurol Sci | 2020 |
Ageing |
| Predicting incident delirium diagnoses using data from primary-care electronic health records | Bowman, K. Jones, L. Masoli, J. Mujica-Mota, R. Strain, D. Butchart, J. Valderas, J. M. Fortinsky, R. H. Melzer, D. Delgado, J. | Age Ageing | 2020 |
at home |
| Comparison of Self-Reported and Behavioral Pain Assessment Tools in Critically Ill Patients | Bouajram, R. H. Sebat, C. M. Love, D. Louie, E. L. Wilson, M. D. Duby, J. J. | J Intensive Care Med | 2020 |
Behavioral Pain Scale |
| Practical Training of Anesthesia Clinicians in Electroencephalogram-Based Determination of Hypnotic Depth of General Anesthesia | Bombardieri, A. M. Wildes, T. S. Stevens, T. Wolfson, M. Steinhorn, R. Ben Abdallah, A. Sleigh, J. Avidan, M. S. | Anesth Analg | 2020 |
Anesthesia, Inhalation |
| A multisite study of nurse-reported perceptions and practice of ABCDEF bundle components | Boehm, L. M. Pun, B. T. Stollings, J. L. Girard, T. D. Rock, P. Hough, C. L. Hsieh, S. J. Khan, B. A. Owens, R. L. Schmidt, G. A. Smith, S. Ely, E. W. | Intensive Crit Care Nurs | 2020 |
ABCDEF bundle |
| Cognitive impairment, clinical symptoms and functional disability in patients emerging from the minimally conscious state | Bodien, Y. G. Martens, G. Ostrow, J. Sheau, K. Giacino, J. T. | NeuroRehabilitation | 2020 |
adult |
| Effect of intravenous iron on functional outcomes in hip fracture: a randomised controlled trial | Bielza, R. Llorente, J. Thuissard, I. J. Andreu-Vázquez, C. Blanco, D. Sanjurjo, J. López, N. Herráez, M. R. Molano, C. Morales, A. Arias, E. Neira, M. Lung, A. Escalera, J. Portillo, L. Larrubia, Y. García, C. Zambrana, F. Gómez Cerezo, J. | Age Ageing | 2020 |
anaemia |
| Tapering with Pharmaceutical GHB or Benzodiazepines for Detoxification in GHB-Dependent Patients: A Matched-Subject Observational Study of Treatment-as-Usual in Belgium and The Netherlands | Beurmanjer, H. Luykx, J. J. De Wilde, B. van Rompaey, K. Buwalda, V. J. A. De Jong, C. A. J. Dijkstra, B. A. G. Schellekens, A. F. A. | CNS Drugs | 2020 | |
| Clinical characteristics and outcomes of inpatients with neurologic disease and COVID-19 in Brescia, Lombardy, Italy | Benussi, A. Pilotto, A. Premi, E. Libri, I. Giunta, M. Agosti, C. Alberici, A. Baldelli, E. Benini, M. Bonacina, S. Brambilla, L. Caratozzolo, S. Cortinovis, M. Costa, A. Piccinelli, S. C. Cottini, E. Cristillo, V. Delrio, I. Filosto, M. Gamba, M. Gazzina | Neurology | 2020 | |
| Palliative sedation: beliefs and decision-making among Spanish palliative care physicians | Benítez-Rosario, M. A. Ascanio-León, B. | Support Care Cancer | 2020 |
Cancer patients |
| A Tunisian version of the confusion assessment method for the intensive care unit (CAM-ICU): translation and validation | Ben Saida, I. Kortli, S. Amamou, B. Kacem, N. Ghardallou, M. Ely, E. W. Ben Saad, H. Boussarsar, M. | BMC Psychiatry | 2020 |
Critical illness |
| 'Socialised care futility' in the care of older people in hospital who call out repetitively: An ethnographic study | Beaver, J. Goldberg, S. E. Edgley, A. Harwood, R. H. | Int J Nurs Stud | 2020 |
Acute hospitals |
| Delirium in COVID-19: A case series and exploration of potential mechanisms for central nervous system involvement | Beach, S. R. Praschan, N. C. Hogan, C. Dotson, S. Merideth, F. Kontos, N. Fricchione, G. L. Smith, F. A. | Gen Hosp Psychiatry | 2020 |
Akinetic mutism |
| Prevalence of delirium in intensive care patients and association with sedoanalgesia, severity and mortality | Bastos, A. S. Beccaria, L. M. Silva, D. C. D. Barbosa, T. P. | Revista gaucha de enfermagem | 2020 |
adult |
| Antipsychotics and the Risk of Mortality or Cardiopulmonary Arrest in Hospitalized Adults | Basciotta, M. Zhou, W. Ngo, L. Donnino, M. Marcantonio, E. R. Herzig, S. J. | J Am Geriatr Soc | 2020 |
antipsychotics |