What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Economic impact of delirium in Australia: a cost of illness study | Pezzullo, L. Streatfeild, J. Hickson, J. Teodorczuk, A. Agar, M. R. Caplan, G. A. | BMJ Open | 2019 |
delirium & cognitive disorders |
| Delirium Predisposing and Triggering Factors in Nursing Home Residents: A Cohort Trial-Nested Case-Control Study | Pérez-Ros, P. Martínez-Arnau, F. M. Baixauli-Alacreu, S. Caballero-Pérez, M. García-Gollarte, J. F. Tarazona-Santabalbina, F. | Journal of Alzheimer's Disease | 2019 |
urinary catheter |
| Preoperative C-Reactive Protein/Albumin Ratio, a Risk Factor for Postoperative Delirium in Elderly Patients After Total Joint Arthroplasty | Peng, J. Wu, G. Chen, J. Chen, H. | Journal of Arthroplasty | 2019 |
aged |
| Combination of lithium and electroconvulsive therapy (ECT) is associated with higher odds of delirium and cognitive problems in a large national sample across the United States | Patel, R. S. Bachu, A. Youssef, N. A. | Brain Stimul | 2019 |
Bipolar disorder |
| The long-term prognosis of patients with delirium in the acute phase of stroke: PRospective Observational POLIsh Study (PROPOLIS) | Pasinska, P. Wilk, A. Kowalska, K. Szyper-Maciejowska, A. Klimkowicz-Mrowiec, A. | J Neurol | 2019 |
Delirium |
| Postoperative Delirium is Associated with Negative Outcomes and Long-Term Mortality in Elderly Koreans: A Retrospective Observational Study | Park, E. A. Kim, M. Y. | Medicina (Kaunas) | 2019 |
delirium |
| Development of a Tool for the Assessment of Nurses' Attitudes Toward Delirium | Papastavrou, E. Papaioannou, M. Evripidou, M. Tsangari, H. Kouta, C. Merkouris, A. | J Nurs Meas | 2019 |
attitude |
| The risk factors associated with delirium after lumbar spine surgery in elderly patients | Pan, Z. Huang, K. Huang, W. Kim, K. H. Wu, H. Yu, Y. Kim, K. N. Yi, S. Shin, D. A. Vora, D. Gragnaniello, C. Phan, K. Tasiou, A. Winder, M. J. Koga, H. Azimi, P. Kang, S. Y. Ha, Y. | Quantitative Imaging in Medicine and Surgery | 2019 |
angiotensin receptor antagonist |
| Incidence, risk factors, and cumulative risk of delirium among ICU patients: A case-control study | Pan, Y. Yan, J. Jiang, Z. Luo, J. Zhang, J. Yang, K. | International Journal of Nursing Sciences | 2019 |
analgesic agent |
| Perioperative dexmedetomidine reduces delirium in elderly patients after non-cardiac surgery: a systematic review and meta-analysis of randomized-controlled trials | Pan, H. Liu, C. Ma, X. Xu, Y. Zhang, M. Wang, Y. | Can J Anaesth | 2019 | |
| International analgesia, sedation, and delirium practices: A prospective cohort study | Owen, G. D. Stollings, J. L. Rakhit, S. Wang, L. Yu, C. Hosay, M. A. Stewart, J. W. Frutos-Vivar, F. Peñuelas, O. Esteban, A. Anzueto, A. R. Raymondos, K. Rios, F. Thille, A. W. González, M. Du, B. Maggiore, S. M. Matamis, D. Abroug, F. Amin, P. Zeggwag | Journal of Intensive Care | 2019 |
NCT02731898 |
| Validation of 3-minute diagnostic interview for CAM-defined Delirium to detect postoperative delirium in the recovery room: A prospective diagnostic study | Olbert, M. Eckert, S. Morgeli, R. Kruppa, J. Spies, C. D. | Eur J Anaesthesiol | 2019 | |
| Antipsychotics for Preventing Delirium in Hospitalized Adults: A Systematic Review | Oh, E. S. Needham, D. M. Nikooie, R. Wilson, L. M. Zhang, A. Robinson, K. A. Neufeld, K. J. | Ann Intern Med | 2019 | |
| Prevention of Early Postoperative Decline: A Randomized, Controlled Feasibility Trial of Perioperative Cognitive Training | O'Gara, B. P. Mueller, A. Gasangwa, D. V. I. Patxot, M. Shaefi, S. Khabbaz, K. Banner-Goodspeed, V. Pascal-Leone, A. Marcantonio, E. R. Subramaniam, B. | Anesth Analg | 2019 | |
| Antipsychotics for Treating Delirium in Hospitalized Adults: A Systematic Review | Nikooie, R. Neufeld, K. J. Oh, E. S. Wilson, L. M. Zhang, A. Robinson, K. A. Needham, D. M. | Ann Intern Med | 2019 | |
| Characteristics of Hospitalized Patients Screening Positive for Delirium | Nguyen, T. H. Atayee, R. S. Derry, K. L. Hirst, J. Biondo, A. Edmonds, K. P. | Am J Hosp Palliative Care | 2019 |
Cam-icu |
| The effect of melatonin on delirium in hospitalised patients: A systematic review and meta-analyses with trial sequential analysis | Ng, K. T. Teoh, W. Y. Khor, A. J. | J Clin Anesth | 2019 |
Agitation |
| Predicting medication-associated altered mental status in hospitalized patients: Development and validation of a risk model | Muñoz, M. A. Jeon, N. Staley, B. Henriksen, C. Xu, D. Weberpals, J. Winterstein, A. G. | American Journal of Health-System Pharmacy | 2019 |
adult |
| Exploiting Machine Learning Algorithms and Methods for the Prediction of Agitated Delirium after Cardiac Surgery | Mufti, H. N. Hirsch, G. M. Abidi, S. R. Abidi, S. S. R. | JMIR Med Inform | 2019 | |
| Risk factors for postoperative delirium in patients undergoing lower extremity joint arthroplasty: a retrospective population-based cohort study | Memtsoudis, S. Cozowicz, C. Zubizarreta, N. Weinstein, S. M. Liu, J. Kim, D. H. Poultsides, L. Berger, M. M. Mazumdar, M. Poeran, J. | Reg Anesth Pain Med | 2019 |
adverse effects |
| Comparison of the incidence and severity of delirium and biochemical factors after coronary artery bypass grafting with dexmedetomidine: A randomized double-blind placebo-controlled clinical trial study | Massoumi, G. Mansouri, M. Khamesipour, S. | ARYA Atherosclerosis | 2019 |
IRCT20171104037209N1 |
| Old Habits Die Hard: Antipsychotics for Treatment of Delirium | Marcantonio, E. R. | Ann Intern Med | 2019 | |
| Episodes of psychomotor agitation among medical patients: findings from a longitudinal multicentre study | Mansutti, I. Venturini, M. Palese, A. | Aging Clin Exp Res | 2019 |
Longitudinal |
| The 4 'A's test for detecting delirium in acute medical patients: a diagnostic accuracy study | MacLullich, A. M. Shenkin, S. D. Goodacre, S. Godfrey, M. Hanley, J. Stiobhairt, A. Lavender, E. Boyd, J. Stephen, J. Weir, C. MacRaild, A. Steven, J. Black, P. Diernberger, K. Hall, P. Tieges, Z. Fox, C. Anand, A. Young, J. Siddiqi, N. Gray, A. | Health Technol Assess | 2019 |
4at |
| Promoting sleep and circadian health may prevent postoperative delirium: A systematic review and meta-analysis of randomized clinical trials | Lu, Y. Li, Y. W. Wang, L. Lydic, R. Baghdoyan, H. A. Shi, X. Y. Zhang, H. | Sleep Med Rev | 2019 |
Meta-analysis |
| A Pilot Study of the Use of Dexmedetomidine for the Control of Delirium by Reducing the Serum Concentrations of Brain-Derived Neurotrophic Factor, Neuron-Specific Enolase, and S100B in Polytrauma Patients | Li, Y. Yu, Z. X. Ji, M. S. Yan, J. Cai, Y. Liu, J. Yang, H. F. Jin, Z. C. | J Intensive Care Med | 2019 |
S100b |
| Effectiveness and harms of pharmacological interventions for the treatment of delirium in adults in intensive care units after cardiac surgery: a systematic review | Leigh, V. Stern, C. Elliott, R. Tufanaru, C. | JBI Database System Rev Implement Rep | 2019 | |
| Physical Activity and Risk of Postoperative Delirium | Lee, S. S. Lo, Y. Verghese, J. | J Am Geriatr Soc | 2019 |
cognitive reserve |
| Predictive Ability of a Serious Game to Identify Emergency Patients With Unrecognized Delirium | Lee, J. S. Tong, T. Tierney, M. C. Kiss, A. Chignell, M. | J Am Geriatr Soc | 2019 |
delirium recognition |
| Could Neutrophil-to-Lymphocyte Ratio (NLR) Serve as a Potential Marker for Delirium Prediction in Patients with Acute Ischemic Stroke? A Prospective Observational Study | Kotfis, K. Bott-Olejnik, M. Szylinska, A. Rotter, I. | J Clin Med | 2019 |
*Crp |
| C-reactive protein for risk prediction of post-operative delirium and post-operative neurocognitive disorder | Knaak, C. Vorderwulbecke, G. Spies, C. Piper, S. K. Hadzidiakos, D. Borchers, F. Brockhaus, W. R. Radtke, F. M. Lachmann, G. | Acta Anaesthesiol Scand | 2019 |
C-reactive protein (CRP) |
| Clinical EEG slowing correlates with delirium severity and predicts poor clinical outcomes | Kimchi, E. Y. Neelagiri, A. Whitt, W. Sagi, A. R. Ryan, S. L. Gadbois, G. Groothuysen, D. Westover, M. B. | Neurology | 2019 | |
| Development of a Risk Score to Predict Postoperative Delirium in Patients With Hip Fracture | Kim, E. M. Li, G. Kim, M. | Anesth Analg | 2019 | |
| Assessment of Delirium Using the Confusion Assessment Method in Older Adult Inpatients in Malaysia | Khor, H. M. Ong, H. C. Tan, B. K. Low, C. M. Saedon, N. Tan, K. M. Chin, A. V. Kamaruzzaman, S. B. Tan, M. P. | Geriatrics (Basel) | 2019 |
Malaysia |
| The value of screening for cognition, depression, and frailty in patients referred for TAVI | Khan, M. M. Lanctôt, K. L. Fremes, S. E. Wijeysundera, H. C. Radhakrishnan, S. Gallagher, D. Gandell, D. Brenkel, M. C. Hazan, E. L. Docteur, N. G. Herrmann, N. | Clinical Interventions in Aging | 2019 |
activity of daily living assessment |
| Medication Use and Risk of Delirium in Mechanically Ventilated Patients | Jin, T. Jin, Y. Lee, S. M. | Clin Nurs Res | 2019 |
delirium |
| Delirium in medical intensive care units: Incidence, subtypes, risk factors, and outcome | Jayaswal, A. Sampath, H. Soohinda, G. Dutta, S. | Indian Journal of Psychiatry | 2019 |
benzodiazepine |
| Risk factors for postoperative delirium after elective major abdominal surgery in elderly patients: A cohort study | Janssen, T. L. Steyerberg, E. W. Faes, M. C. Wijsman, J. H. Gobardhan, P. D. Ho, G. H. van der Laan, L. | Int J Surg | 2019 |
Abdominal aortic aneurysm |
| Prevention of postoperative delirium in elderly patients planned for elective surgery: Systematic review and meta-analysis | Janssen, T. L. Alberts, A. R. Hooft, L. Mattace-Raso, F. U. S. Mosk, C. A. Van Der Laan, L. | Clinical Interventions in Aging | 2019 |
bupivacaine |
| Ramelteon for Prevention of Postoperative Delirium: A Randomized Controlled Trial in Patients Undergoing Elective Pulmonary Thromboendarterectomy | Jaiswal, S. J. Vyas, A. D. Heisel, A. J. Ackula, H. Aggarwal, A. Kim, N. H. Kerr, K. M. Madani, M. Pretorius, V. Auger, W. R. Fernandes, T. M. Malhotra, A. Owens, R. L. | Crit Care Med | 2019 | |
| Effect and analysis of ulinastatin combined with thymosin on cardiopulmonary function and delirium in sepsis patients | Huanling, S. Rongju, L. Min, J. | Pakistan Journal of Pharmaceutical Sciences | 2019 |
adult |
| Pre-emptive analgesia with continuous fascia iliaca compartment block reduces postoperative delirium in elderly patients with hip fracture. A randomized controlled trial | Hao, J. Dong, B. Zhang, J. Luo, Z. | Saudi Med J | 2019 | |
| Supratherapeutic Psychotropic Drug Levels in the Emergency Department and Their Association with Delirium Duration: A Preliminary Study | Han, J. H. Chen, A. Vasilevskis, E. E. Schnelle, J. F. Ely, E. W. Chandrasekhar, R. Morrison, R. D. Ryan, T. P. Daniels, J. S. Sutherland, J. J. Simmons, S. F. | J Am Geriatr Soc | 2019 |
adverse drug reactions |
| Post-traumatic stress disorder (PTSD) related symptoms following an experience of delirium | Grover, S. Sahoo, S. Chakrabarti, S. Avasthi, A. | J Psychosom Res | 2019 |
Delirium |
| Prediction of ICU Delirium: Validation of Current Delirium Predictive Models in Routine Clinical Practice∗ | Green, C. Bonavia, W. Toh, C. Tiruvoipati, R. | Critical Care Medicine | 2019 |
dexmedetomidine |
| Pain Screening in the Older Adult With Delirium | Goebel, J. R. Ferolito, M. Gorman, N. | Pain Manag Nurs | 2019 | |
| Use of tailored feedback improves accuracy of delirium documentation in the Burn ICU: Results of a Performance Improvement initiative | Gloger, A. N. Nakonezny, P. A. Phelan, H. A. | J Burn Care Res | 2019 |
Accuracy |
| Validation and Psychometric Properties of the German Version of the Delirium Motor Subtype Scale (DMSS) | Garcia Nuñez, D. Boettger, S. Meyer, R. Richter, A. Schubert, M. Meagher, D. Jenewein, J. | Assessment | 2019 |
adult |
| Delirium and post-discharge dementia: results from a cohort of older adults without baseline cognitive impairment | Garcez, F. B. Apolinario, D. Campora, F. Curiati, J. A. E. Jacob-Filho, W. Avelino-Silva, T. J. | Age Ageing | 2019 |
cognitive decline |
| The effects of multimedia education on postoperative delirium in patients undergoing coronary artery bypass graft: A randomized clinical trial | Fahimi, K. Abbasi, A. Zahedi, M. Amanpour, F. Ebrahimi, H. | Nurs Crit Care | 2019 |
coronary artery bypass graft |
| Independent Association Between Type of Intra-Operative Blood Transfusion and Post-Operative Delirium After Complex Spinal Fusion for Adult Deformity Correction | Elsamadicy, A. A. Adil, S. M. Charalambous, L. Drysdale, N. Koo, A. B. Lee, M. Kundishora, A. J. Camara-Quintana, J. Kolb, L. Laurans, M. Abbed, K. Karikari, I. O. | Spine | 2019 | |
| Effects of protocol on prevention of delirium in hospitalized hip fracture patients: A quality improvement project | Durst, J. Wilson, D. | Int J Orthop Trauma Nurs | 2019 |
Delirium |
| The effect of perioperative anesthetics for prevention of postoperative delirium on general anesthesia: A network meta-analysis | Cui, Y. Li, G. Cao, R. Luan, L. Kla, K. M. | J Clin Anesth | 2019 |
Hypotension |
| Quality of recovery in elderly patients with postoperative delirium | Cristelo, D. Ferreira, M. Castro, J. Teles, A. Campos, M. Abelha, F. | Saudi Journal of Anaesthesia | 2019 |
adult |
| Delirium Reduced With Intravenous Acetaminophen in Geriatric Hip Fracture Patients | Connolly, K. P. Kleinman, R. S. Stevenson, K. L. Neuman, M. D. Mehta, S. N. | J Am Acad Orthop Surg | 2019 | |
| The effect of a multidisciplinary care bundle on the incidence of delirium after hip fracture surgery: a quality improvement study | Chuan, A. Zhao, L. Tillekeratne, N. Alani, S. Middleton, P. M. Harris, I. A. McEvoy, L. Ní Chróinín D | Anaesthesia | 2019 |
adult |
| Associations between frailty and delirium among older patients admitted to an Emergency Department | Choutko-Joaquim, S. Tacchini-Jacquier, N. Pralong D'Alessio, G. Verloo, H. | Dementia and Geriatric Cognitive Disorders Extra | 2019 |
aged |
| Effect of anesthetic method on incidence of delirium after total hip replacement arthroplasty in South Korea: a population-based study using national health insurance claims data | Choi, E. J. Choi, Y. J. Lee, S. W. Choi, Y. M. Ri, H. S. Park, J. Y. Park, S. J. Son, J. M. Lee, Y. S. | Korean J Anesthesiol | 2019 |
Delirium |
| Impact of Cognitive Impairment Across Specialties: Summary of a Report From the U13 Conference Series | Carpenter, C. R. McFarland, F. Avidan, M. Berger, M. Inouye, S. K. Karlawish, J. Lin, F. R. Marcantonio, E. Morris, J. C. Reuben, D. B. Shah, R. C. Whitson, H. E. Asthana, S. Verghese, J. | J Am Geriatr Soc | 2019 |
Aging |
| Pharmacological interventions for the treatment of delirium in critically ill adults | Burry, L. Hutton, B. Williamson, D. R. Mehta, S. Adhikari, N. K. Cheng, W. Ely, E. W. Egerod, I. Fergusson, D. A. Rose, L. | Cochrane Database Syst Rev | 2019 | |
| Unrecognized Incident Delirium in Older Emergency Department Patients | Boucher, V. Lamontagne, M. E. Nadeau, A. Carmichael, P. H. Yadav, K. Voyer, P. Pelletier, M. Gouin, E. Daoust, R. Berthelot, S. Morin, M. Lemire, S. Minh Vu, T. T. Lee, J. Emond, M. | J Emerg Med | 2019 |
delirium |
| Delirium in the intensive care setting dependent on the Richmond Agitation and Sedation Scale (RASS): Inattention and visuo-spatial impairment as potential screening domains | Boettger, S. Meyer, R. Richter, A. Rudiger, A. Schubert, M. Jenewein, J. Nunez, D. G. | Palliat Support Care | 2019 |
Drs-r-98 |
| Analgesic and psychoactive medications and the risk of falls in relation to delirium in single-bed rooms compared to multiple-bed rooms in geriatric inpatients | Blandfort, S. Gregersen, M. Rahbek, K. Juul, S. Damsgaard, E. M. | Aging Clin Exp Res | 2019 |
Analgesic |
| "They take a lot of pressure off us": Volunteers reducing staff and family care burden and contributing to quality of care for older patients with cognitive impairment in rural hospitals | Blair, A. Bateman, C. Anderson, K. | Australas J Ageing | 2019 |
delirium |
| Portal Hypertension Is Associated With Congestive Encephalopathy and Delirium After Cardiac Surgery | Benkreira, A. Beaubien-Souligny, W. Mailhot, T. Bouabdallaoui, N. Robillard, P. Desjardins, G. Lamarche, Y. Cossette, S. Denault, A. | Can J Cardiol | 2019 | |
| Occurrence and Practices for Pain, Agitation, and Delirium in Intensive Care Unit Patients | Arroyo-Novoa, C. M. Figueroa-Ramos, M. I. Puntillo, K. A. | P R Health Sci J | 2019 |
Agitation |
| Arabic intensive care delirium screening checklist's validity and reliability: A multicenter study | Al-Qadheeb, N. S. Nazer, L. H. Aisa, T. M. Osman, H. O. Rugaan, A. S. Alzahrani, A. S. Ghonimat, I. M. Mohammed, A. M. Maghrabi, K. Alrowaished, A. A. Hussein, N. H. Maslamani, Y. A. Falatah, S. Skrobik, Y. | J Crit Care | 2019 |
Arabic |
| The association of preoperative delirium with postoperative outcomes following hip surgery in the elderly | Agrawal, S. Turk, R. Burton, B. N. Ingrande, J. Gabriel, R. A. | J Clin Anesth | 2019 |
Acs nsqip |
| Factors associated with falling in elderly hospital patients. | Salgado R, Lord SR, Packer J, Ehrlich F | Gerontology | 1994 |
Accidental Falls, Aged, Aged, 80 and over, Case-Control Studies, Cerebrovascular Disorders, complications, Cognition Disorders, complications, Female, Hospitalization, Humans, Male, Postural Balance, Psychotropic Drugs, therapeutic use, Retrospective Studies, Risk Factors |
| Delirium and physical restraint in the hospitalized elderly. | Sullivan-Marx EM | Image--the journal of nursing scholarship | 1994 |
Aged, Cognition Disorders, psychology, Delirium, nursing, Female, Hospitalization, Humans, Inpatients, psychology, Male, Nursing Assessment, Psychomotor Agitation, Restraint, Physical, Risk Factors |
| Increasing the recognition of delirium in elderly patients. | Rockwood K, Cosway S, Stolee P, Kydd D, Carver D, Jarrett P, O'Brien B | Journal of the American Geriatrics Society | 1994 |
Aged, Cognition, Confusion, Delirium, diagnosis, Educational Status, Female, Humans, Inpatients, Male, Medical Staff, Hospital, Psychiatric Status Rating Scales |
| The relationship of postoperative delirium with psychoactive medications. | Marcantonio ER, Juarez G, Goldman L, Mangione CM, Ludwig LE, Lind L, Katz N, Cook EF, Orav EJ, Lee TH | JAMA | 1994 |
Aged, Analgesia, Epidural, Analgesia, Patient-Controlled, Benzodiazepines, administration & dosage, Case-Control Studies, Cholinergic Antagonists, administration & dosage, Delirium, diagnosis, Humans, Logistic Models, Matched-Pair Analysis, Mental Status Schedule, Middle Aged, Narcotics, administration & dosage, Postoperative Period, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors |
| Detection of psychiatric disorders in elderly medical inpatients. | Bowler C, Boyle A, Branford M, Cooper SA, Harper R, Lindesay J | Age and ageing | 1994 |
Aged, Aged, 80 and over, Delirium, diagnosis, Delirium, Dementia, Amnestic, Cognitive Disorders, diagnosis, Dementia, diagnosis, Female, Geriatrics, Hospital Units, Humans, Inpatients, Male, Mental Disorders, diagnosis, Middle Aged, Nursing Assessment |
| Predictors of formal home health care use in elderly patients after hospitalization. | Solomon DH, Wagner DR, Marenberg ME, Acampora D, Cooney LM, Inouye SK | Journal of the American Geriatrics Society | 1993 |
Activities of Daily Living, Age Factors, Aged, Aged, 80 and over, Comorbidity, Confidence Intervals, Educational Status, Female, Forecasting, Geriatric Assessment, Health Planning, Health Services Research, Home Care Services, statistics & numerical data, Hospitalization, Humans, Male, Patient Discharge, Patient Readmission, Proportional Hazards Models, Prospective Studies, Risk Factors, Severity of Illness Index, Social Support |
| Cognitive performance in a high-functioning community-dwelling elderly population. | Inouye SK, Albert MS, Mohs R, Sun K, Berkman LF | Journal of gerontology | 1993 |
Aged, psychology, Cognition, Female, Humans, Male, Memory, Socioeconomic Factors |
| Hazards of hospitalization of the elderly. | Creditor MC | Annals of internal medicine | 1993 |
Accidental Falls, Activities of Daily Living, Aged, Aging, physiology, Bed Rest, adverse effects, Frail Elderly, Hospitalization, Humans, Iatrogenic Disease, Nursing Homes, Risk Factors |
| Acute confusion in the elderly. | Foreman MD | Annual review of nursing research | 1993 |
Acute Disease, Age Factors, Aged, Confusion, diagnosis, Forecasting, Geriatric Assessment, Geriatric Nursing, methods, Humans, Incidence, Mental Status Schedule, Nursing Assessment, Nursing Research, trends, Prevalence, Prognosis, Risk Factors, Terminology as Topic |
| Adverse events in the hospitalized elderly. | Foreman MD, Theis SL, Anderson MA | Clinical nursing research | 1993 |
Age Factors, Aged, Confusion, epidemiology, Drug Hypersensitivity, epidemiology, Female, Hospitalization, Humans, Incidence, Male, Pressure Ulcer, epidemiology |
| Delirium in hospitalized elderly patients: recognition, evaluation, and management. | Inouye SK | Connecticut medicine | 1993 |
Aged, Delirium, diagnosis, Diagnosis, Differential, Geriatric Assessment, Hospitalization, Humans, Neurologic Examination |
| A predictive model for delirium in hospitalized elderly medical patients based on admission characteristics. | Inouye SK, Viscoli CM, Horwitz RI, Hurst LD, Tinetti ME | Annals of internal medicine | 1993 |
Aged, Aged, 80 and over, Cognition Disorders, complications, Decision Support Techniques, Dehydration, complications, Delirium, complications, Female, Hospitalization, Humans, Male, Patient Admission, Prospective Studies, Risk Factors, Severity of Illness Index, Vision Disorders, complications |
| A predictive index for functional decline in hospitalized elderly medical patients. | Inouye SK, Wagner DR, Acampora D, Horwitz RI, Cooney LM, Hurst LD, Tinetti ME | Journal of general internal medicine | 1993 |
Activities of Daily Living, Aged, Aged, 80 and over, Chi-Square Distribution, Cohort Studies, Connecticut, Female, Geriatric Assessment, Hospital Bed Capacity, 500 and over, Hospitals, University, utilization, Humans, Likelihood Functions, Male, Multivariate Analysis, Prevalence, Proportional Hazards Models, Prospective Studies, Reproducibility of Results, Risk Factors, Single-Blind Method |
| A prospective study of delirium in elderly patients admitted to a psychiatric hospital. | Koponen HJ, Riekkinen PJ | Psychological medicine | 1993 |
Aged, Brain, physiopathology, Brain Diseases, complications, Delirium, diagnosis, Female, Follow-Up Studies, Hospitalization, Humans, Male, Patient Admission, Patient Discharge, Prospective Studies, Psychiatric Status Rating Scales |
| Challenge for the 90s: a safe and cost-effective sitter program. | Lipkis-Orlando R, Mian P, Levy G, Lussier-Cushing M | Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses | 1993 |
Cost-Benefit Analysis, Humans, Job Description, Mental Disorders, nursing, Nurses’ Aides, Psychiatric Nursing, economics |
| Delirium in hospitalized elderly patients. | Pompei P | Hospital practice (Office ed.) | 1993 |
Aged, Aged, 80 and over, Blood Glucose, Cognition, Delirium, complications, Female, Glucose, therapeutic use, Hospitalization, Humans, Lung Diseases, Obstructive, complications, Mental Status Schedule, Prognosis |
| Acute delirium and functional decline in the hospitalized elderly patient. | Murray AM, Levkoff SE, Wetle TT, Beckett L, Cleary PD, Schor JD, Lipsitz LA, Rowe JW, Evans DA | Journal of gerontology | 1993 |
Activities of Daily Living, Acute Disease, Aged, Boston, Delirium, physiopathology, Female, Geriatric Assessment, Hospitalization, Hospitals, Teaching, Humans, Linear Models, Male, Nursing Homes, Prospective Studies, Risk Factors |
| A controlled trial of a nursing-centered intervention in hospitalized elderly medical patients: the Yale Geriatric Care Program. | Inouye SK, Wagner DR, Acampora D, Horwitz RI, Cooney LM, Tinetii ME | Journal of the American Geriatrics Society | 1993 |
Activities of Daily Living, Aged, Aged, 80 and over, Connecticut, Female, Geriatric Assessment, Geriatric Nursing, organization & administration, Hospital Bed Capacity, 500 and over, Hospitals, University, organization & administration, Humans, Intervention Studies, Male, Models, Nursing, Nursing Service, Hospital, organization & administration, Outcome Assessment (Health Care), Patient Care Team, Prospective Studies |
| Hospital Outcomes Project for the Elderly (HOPE): rationale and design for a prospective pooled analysis. | Margitić SE, Inouye SK, Thomas JL, Cassel CK, Regenstreif DI, Kowal J | Journal of the American Geriatrics Society | 1993 |
Activities of Daily Living, Aged, Aged, 80 and over, Female, Health Services Research, methods, Hospitalization, Humans, Male, Outcome Assessment (Health Care), Prospective Studies, United States |
| The Yale Geriatric Care Program: a model of care to prevent functional decline in hospitalized elderly patients. | Inouye SK, Acampora D, Miller RL, Fulmer T, Hurst LD, Cooney LM | Journal of the American Geriatrics Society | 1993 |
Activities of Daily Living, Aged, Connecticut, Education, Nursing, Continuing, Geriatric Assessment, Geriatric Nursing, methods, Hospitals, University, organization & administration, Humans, Intervention Studies, Models, Nursing, Nursing Service, Hospital, organization & administration, Outcome and Process Assessment (Health Care), Patient Care Team, Prospective Studies |
| Interrupted care. The effects of paging on pediatric resident activities. | Blum NJ, Lieu TA | American journal of diseases of children (1960) | 1992 |
Burnout, Professional, epidemiology, Evaluation Studies as Topic, Hospital Communication Systems, statistics & numerical data, Hospitals, Pediatric, Hospitals, University, Humans, Internship and Residency, statistics & numerical data, Medical Staff, Hospital, psychology, Pediatrics, standards, Philadelphia, epidemiology, Prospective Studies, Quality of Health Care, Risk Factors |
| Delirium in older patients. | Francis J | Journal of the American Geriatrics Society | 1992 |
Aged, Clinical Protocols, Delirium, diagnosis, Diagnosis, Differential, Drug-Related Side Effects and Adverse Reactions, Forecasting, Geriatrics, methods, Humans, Incidence, Prevalence, Prognosis, Risk Factors |
| Diagnostic dilemma: cognitive impairment in the elderly. | Foreman MD, Grabowski R | Journal of gerontological nursing | 1992 |
Aged, Cognition Disorders, classification, Diagnosis, Differential, Humans, Mental Status Schedule |
| Delirium in newly admitted elderly patients: a prospective study. | Jitapunkul S, Pillay I, Ebrahim S | The Quarterly journal of medicine | 1992 |
Acute Disease, psychology, Aged, Aged, 80 and over, Delirium, epidemiology, Female, Humans, Intelligence Tests, Length of Stay, London, Long-Term Care, Male, Middle Aged, Patient Admission, statistics & numerical data, Prevalence, Prospective Studies |
| Confusion in the elderly hospitalized patient. | McBride S | The Canadian nurse | 1992 |
Aged, Confusion, nursing, Geriatric Nursing, methods, Hospitalization, Humans, Patient Education as Topic |
| Delirium. The occurrence and persistence of symptoms among elderly hospitalized patients. | Levkoff SE, Evans DA, Liptzin B, Cleary PD, Lipsitz LA, Wetle TT, Reilly CH, Pilgrim DM, Schor J, Rowe J | Archives of internal medicine | 1992 |
Aged, Aged, 80 and over, Cognition, Delirium, diagnosis, Female, Hospitalization, Humans, Length of Stay, Male, Prospective Studies, Risk Factors |
| Dealing with delirium. A common problem in hospitalized elderly patients. | O'Brien ME | Postgraduate medicine | 1992 |
Aged, Delirium, diagnosis, Dementia, diagnosis, Diagnosis, Differential, Geriatrics, Hospitalization, Humans |
| Delirium in the medically ill elderly: operationalizing the DSM-III criteria. | Gottlieb GL, Johnson J, Wanich C, Sullivan E | International psychogeriatrics / IPA | 1991 |
Aged, Delirium, diagnosis, Female, Hospitalization, Humans, Male, Neuropsychological Tests, statistics & numerical data, Patient Care Team, Pennsylvania, epidemiology, Psychiatric Status Rating Scales, statistics & numerical data, Psychometrics |
| Epidemiology of delirium: an overview of research issues and findings. | Levkoff S, Cleary P, Liptzin B, Evans DA | International psychogeriatrics / IPA | 1991 |
Aged, Cross-Sectional Studies, Delirium, diagnosis, Humans, Incidence, Neuropsychological Tests, Psychiatric Status Rating Scales, United States, epidemiology |
| An empirical study of diagnostic criteria for delirium. | Liptzin B, Levkoff SE, Cleary PD, Pilgrim DM, Reilly CH, Albert M, Wetle TT | The American journal of psychiatry | 1991 |
Aged, Aged, 80 and over, Delirium, classification, Humans, Inpatients, psychology, Length of Stay, statistics & numerical data, Psychiatric Status Rating Scales, Psychometrics, Research Design, Terminology as Topic |
| Cognitive impairment and hospital use. | Weiler PG, Lubben JE, Chi I | American journal of public health | 1991 |
Activities of Daily Living, Aged, Aged, 80 and over, Cognition Disorders, etiology, Cohort Studies, Dementia, complications, Female, Hospitalization, statistics & numerical data, Humans, Intelligence Tests, Length of Stay, statistics & numerical data, Male, Odds Ratio, Random Allocation |
| Advancing age and the syndrome of delirium: ancient conundrums and modern research advances. | Miller NE, Lipowski ZJ | International psychogeriatrics / IPA | 1991 |
Aged, Arousal, physiology, Brain, physiopathology, Delirium, etiology, Electroencephalography, Humans, Length of Stay, Neuropsychological Tests, Neurotransmitter Agents, physiology |