What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
Title | Authors | Journal | Year | Keywords |
---|---|---|---|---|
Development and validation of a postoperative delirium prediction model for patients admitted to an intensive care unit in China: a prospective study | Xing, H. Zhou, W. Fan, Y. Wen, T. Wang, X. Chang, G. | BMJ Open | 2019 |
delirium |
Acute kidney injury as a risk factor of hyperactive delirium: A case control study | Wan, R. McKenzie, C. A. Taylor, D. Camporota, L. Ostermann, M. | J Crit Care | 2019 |
Acute kidney injury |
The Effect of Frailty on Outcome After Vascular Surgery | Visser, L. Banning, L. B. D. El Moumni, M. Zeebregts, C. J. Pol, R. A. | European Journal of Vascular and Endovascular Surgery | 2019 |
adverse outcome |
Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions | Vasunilashorn, S. M. Ngo, L. H. Inouye, S. K. Fong, T. G. Jones, R. N. Dillon, S. T. Libermann, T. A. O'Connor, M. Arnold, S. E. Xie, Z. Marcantonio, E. R. | Alzheimers Dement | 2019 |
Apolipoprotein E |
In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium | Vahidy, F. S. Bambhroliya, A. B. Meeks, J. R. Rahman, O. Ely, E. W. Slooter, A. J. C. Tyson, J. E. Miller, C. C. McCullough, L. D. Savitz, S. I. Khan, B. | PLoS One | 2019 | |
Reducing delirium and cognitive dysfunction after off-pump coronary bypass: A randomized trial | Szwed, K. Pawliszak, W. Szwed, M. Tomaszewska, M. Anisimowicz, L. Borkowska, A. | Journal of Thoracic and Cardiovascular Surgery | 2019 |
adult |
A randomized control trial comparing prophylactic dexmedetomidine versus clonidine on rates and duration of delirium in older adult patients undergoing coronary artery bypass grafting | Shokri, H. Ali, I. | Journal of Clinical Anesthesia | 2019 |
adult |
Predisposing and precipitating risk factors for delirium in palliative care patients | Seiler, A. Schubert, M. Hertler, C. Schettle, M. Blum, D. Guckenberger, M. Weller, M. Ernst, J. von Kanel, R. Boettger, S. | Palliat Support Care | 2019 |
Delirium |
Preventive effect of dexmedetomidine on postictal delirium after electroconvulsive therapy: A randomised controlled study | Qiu, Z. Zhou, S. Zhang, M. Guo, N. Huang, P. Xiang, P. Hei, Z. Li, X. | Eur J Anaesthesiol | 2019 | |
Activity-based occupational therapy intervention for delirium superimposed on dementia in nursing home setting: a feasibility study | Pozzi, C. Lanzoni, A. Lucchi, E. Salimbeni, I. DeVreese, L. P. Bellelli, G. Fabbo, A. Morandi, A. | Aging Clin Exp Res | 2019 |
Delirium |
Trials Focusing on Prevention and Treatment of Delirium After Cardiac Surgery: A systematic Review of Randomized Evidence | Pieri, M. De Simone, A. Rose, S. De Domenico, P. Lembo, R. Denaro, G. Landoni, G. Monaco, F. | Journal of Cardiothoracic and Vascular Anesthesia | 2019 |
adult |
Association of comt val158met polymorphism with delirium risk and outcomes after traumatic brain injury | Nekrosius, D. Kaminskaite, M. Jokubka, R. Pranckeviciene, A. Lideikis, K. Tamasauskas, A. Bunevicius, A. | Journal of Neuropsychiatry and Clinical Neurosciences | 2019 |
methionine |
Anticholinergic burden of long-term medication is an independent risk factor for the development of postoperative delirium: A clinical trial | Mueller, A. Spies, C. D. Eckardt, R. Weiss, B. Pohrt, A. Wernecke, K. D. Schmidt, M. | Journal of Clinical Anesthesia | 2019 |
aged |
Renal function and delirium in older fracture patients: different information from different formulas? | Mossello, E. Rivasi, G. Tortu, V. Giordano, A. Iacomelli, I. Cavallini, M. C. Rafanelli, M. Ceccofiglio, A. Cartei, A. Rostagno, C. Bari, M. D. Ungar, A. | Eur J Intern Med | 2019 |
Creatinine |
Reversibility of delirium in Ill-hospitalized cancer patients: Does underlying etiology matter? | Matsuda, Y. Maeda, I. Morita, T. Yamauchi, T. Sakashita, A. Watanabe, H. Kaneishi, K. Amano, K. Iwase, S. Ogawa, A. Yoshiuchi, K. | Cancer Med | 2019 |
cancer |
Association Between Perioperative Hypotension and Delirium in Postoperative Critically Ill Patients: A Retrospective Cohort Analysis | Maheshwari, K. Ahuja, S. Khanna, A. K. Mao, G. Perez-Protto, S. Farag, E. Turan, A. Kurz, A. Sessler, D. I. | Anesth Analg | 2019 | |
A short delirium caregiver questionnaire for triage of elderly outpatients with cognitive impairment: a development and test accuracy study | Luijendijk, H. J. Quispel-Aggenbach, D. W. P. Stroomer-van Wijk, A. J. M. Meijerink-Blom, A. H. van Walbeek, A. Zuidema, S. U. | International Psychogeriatrics | 2019 |
aged |
Intraoperative Oxidative Damage and Delirium after Cardiac Surgery | Lopez, M. G. Hughes, C. G. DeMatteo, A. O'Neal, J. B. McNeil, J. B. Shotwell, M. S. Morse, J. Petracek, M. R. Shah, A. S. Brown, N. J. Billings, F. T. th | Anesthesiology | 2019 | |
Postoperative delirium after hip surgery is a potential risk factor for incident dementia: A systematic review and meta-analysis of prospective studies | Lee, S. J. Jung, S. H. Lee, S. U. Lim, J. Y. Yoon, K. S. Lee, S. Y. | Arch Gerontol Geriatr | 2019 |
Delirium |
Evaluation of emergency department derived delirium prediction models using a hospital-wide cohort | Lee, S. Harland, K. Mohr, N. M. Matthews, G. Hess, E. P. Bellolio, M. F. Han, J. H. Weckmann, M. Carnahan, R. | Journal of Psychosomatic Research | 2019 |
aged |
The Practical Use of White Cell Inflammatory Biomarkers in Prediction of Postoperative Delirium after Cardiac Surgery | Kotfis, K. Slozowska, J. Safranow, K. Szylinska, A. Listewnik, M. | Brain Sci | 2019 |
Nlr |
Characteristics, risk factors and outcome of early-onset delirium in elderly patients with first ever acute ischemic stroke-A prospective observational cohort study | Kotfis, K. Bott-Olejnik, M. Szylińska, A. Listewnik, M. Rotter, I. | Clinical Interventions in Aging | 2019 |
NCT03944694 |
Biomarkers of Delirium Duration and Delirium Severity in the ICU | Khan, B. A. Perkins, A. J. Prasad, N. K. Shekhar, A. Campbell, N. L. Gao, S. Wang, S. Khan, S. H. Marcantonio, E. R. Twigg, H. L., 3rd Boustani, M. A. | Crit Care Med | 2019 | |
The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile | Hshieh, T. T. Vasunilashorn, S. M. D'Aquila, M. L. Arnold, S. E. Dickerson, B. C. Fong, T. G. Jones, R. N. Marcantonio, E. R. Schmitt, E. M. Xu, G. Gou, Y. Chen, F. Kunze, L. J. Vlassakov, K. V. Abdeen, A. R. Lange, J. K. Earp, B. E. Touroutoglou, A. Carl | Alzheimers Dement | 2019 |
Biomarkers |
Clock Drawing Performance Slows for Older Adults after Total Knee Replacement Surgery | Hizel, L. P. Warner, E. D. Wiggins, M. E. Tanner, J. J. Parvataneni, H. Davis, R. Penney, D. L. Libon, D. J. Tighe, P. Garvan, C. W. Price, C. C. | Anesthesia and Analgesia | 2019 |
nct01786577 |
Postoperative delirium after lung resection for primary lung cancer: Risk factors, risk scoring system, and prognosis | Hayashi, K. Motoishi, M. Sawai, S. Horimoto, K. Hanaoka, J. | PLoS One | 2019 | |
Intraoperative Low Alpha Power in the Electroencephalogram Is Associated With Postoperative Subsyndromal Delirium | Gutierrez, R. Egaña, J. I. Saez, I. Reyes, F. Briceño, C. Venegas, M. Lavado, I. Penna, A. | Frontiers in Systems Neuroscience | 2019 |
electroencephalograph |
Post-operative delirium associated with metabolic alterations following hemi-arthroplasty in older patients | Guo, Y. Li, Y. Zhang, Y. Fang, S. Xu, X. Zhao, A. Zhang, J. Li, J. V. Ma, D. Jia, W. Jiang, W. | Age Ageing | 2019 |
hip fracture |
Validation of the Delirium Diagnostic Tool-Provisional (DDT-Pro) With Medical Inpatients and Comparison With the Confusion Assessment Method Algorithm | Franco, J. G. Ocampo, M. V. Velásquez-Tirado, J. D. Zaraza, D. R. Giraldo, A. M. Serna, P. A. López, C. Zuluaga, A. Sepúlveda, E. Kean, J. Trzepacz, P. T. | Journal of Neuropsychiatry and Clinical Neurosciences | 2019 |
administrative personnel |
Efficacy and safety of haloperidol for delirium prevention in adult patients: An updated meta-analysis with trial sequential analysis of randomized controlled trials | Chen, Z. Chen, R. Zheng, D. Su, Y. Wen, S. Guo, H. Ye, Z. Deng, Y. Liu, G. Zuo, L. Wei, X. Hou, Y. | Journal of Clinical Anesthesia | 2019 |
adult |
Change in Serum Level of Interleukin 6 and Delirium After Coronary Artery Bypass Graft | Chen, Y. Lu, S. Wu, Y. Shen, Y. Zhao, H. Ding, S. Feng, X. Sun, L. Tao, X. Li, J. Ma, R. Liu, W. Wu, F. Feng, Y. | Am J Crit Care | 2019 | |
Preoperative cardiac function parameters as valuable predictors for nurses to recognise delirium after cardiac surgery: a prospective cohort study | Cai, S. Latour, J. M. Lin, Y. Pan, W. Zheng, J. Xue, Y. Gao, J. Lv, M. Zhang, X. Luo, Z. Wang, C. Zhang, Y. | Eur J Cardiovasc Nurs | 2019 |
Cardiac surgery |
Bedside mental status and outcome in elderly patients admitted for acute coronary syndromes | Briet, C. Blanchart, K. Lemaitre, A. Roux, I. Lavergne, K. Rocamora, A. Bignon, M. Ardouin, P. Sabatier, R. Roule, V. Beygui, F. | Heart | 2019 |
acute coronary syndrome |
Delirium Screening in Aphasic Patients With the Intensive Care Delirium Screening Checklist (ICDSC): A Prospective Cohort Study | Bosselmann, C. Zurloh, J. Stefanou, M. I. Stadler, V. Weber, Y. Lerche, H. Poli, S. Ziemann, U. Mengel, A. | Front Neurol | 2019 |
intensive care delirium screening checklist |
Impact of Frailty on 30-Day Morbidity and Mortality of Patients With Intertrochanteric Femur Fractures | Boissonneault, A. Mener, A. Schwartz, A. Wilson, J. Staley, C. Schenker, M. | Orthopedics | 2019 | |
The utility of nursing instruments for daily screening for delirium: Delirium causes substantial functional impairment | Bode, L. Isler, F. Fuchs, S. Marquetand, J. Petry, H. Ernst, J. Schubert, M. Garcia Nunez, D. von Kanel, R. Boettger, S. | Palliat Support Care | 2019 |
Assessment |
The short IQCODE as a predictor for delirium in hospitalized geriatric patients | Blandfort, S. Gregersen, M. Rahbek, K. Juul, S. Damsgaard, E. M. | Aging Clin Exp Res | 2019 |
Delirium predictor |
The relationship among frailty, delirium and attentional tests to detect delirium: a cohort study | Bellelli, P. G. Biotto, M. Morandi, A. Meagher, D. Cesari, M. Mazzola, P. Annoni, G. Zambon, A. | Eur J Intern Med | 2019 |
Attention |
Haloperidol for the treatment of delirium in critically ill patients: A systematic review with meta-analysis and Trial Sequential Analysis | Barbateskovic, M. Krauss, S. R. Collet, M. O. Andersen-Ranberg, N. C. Mathiesen, O. Jakobsen, J. C. Perner, A. Wetterslev, J. | Acta Anaesthesiologica Scandinavica | 2019 |
adult |
The Volunteer Dementia and Delirium Care (VDDC) © Program: An Exploration of Perceived Barriers and Enablers to Implementation in an Acute and Subacute Metropolitan Hospital | Ayton, D. Moran, C. Berkovic, D. Bateman, C. Anderson, K. Blair, A. Soh, S. E. Morello, R. Ying Lim, Y. Liew, D. | Australas J Ageing | 2019 |
delirium |
Comorbidities rather than age affect medium-term outcome in octogenarian patients after total knee arthroplasty | Andreozzi, V. Conteduca, F. Iorio, R. Di Stasio, E. Mazza, D. Drogo, P. Annibaldi, A. Ferretti, A. | Knee Surg Sports Traumatol Arthrosc | 2019 |
Comorbidity |
Effect of the Tailored, Family-Involved Hospital Elder Life Program on Postoperative Delirium and Function in Older Adults: A Randomized Clinical Trial | Wang, Y. Y. Yue, J. R. Xie, D. M. Carter, P. Li, Q. L. Gartaganis, S. L. Chen, J. Inouye, S. K. | JAMA Intern Med | 2019 | |
Nomogram for Predicting Postoperative Delirium After Deep Brain Stimulation Surgery for Parkinson's Disease | Wang, X. Q. Zhuang, H. X. Zhang, L. X. Chen, X. Niu, C. S. Zhao, M. | World Neurosurg | 2019 |
Deep brain stimulation |
Automated tracking of level of consciousness and delirium in critical illness using deep learning | Sun, H. Kimchi, E. Akeju, O. Nagaraj, S. B. McClain, L. M. Zhou, D. W. Boyle, E. Zheng, W. L. Ge, W. Westover, M. B. | NPJ Digital Medicine | 2019 |
propofol |
Impact of natural light exposure on delirium burden in adult patients receiving invasive mechanical ventilation in the ICU: a prospective study | Smonig, R. Magalhaes, E. Bouadma, L. Andremont, O. de Montmollin, E. Essardy, F. Mourvillier, B. Lebut, J. Dupuis, C. Neuville, M. Lermuzeaux, M. Timsit, J. F. Sonneville, R. | Ann Intensive Care | 2019 |
Agitation |
Differences in 90-day mortality of delirium subtypes in the intensive care unit: A retrospective cohort study | Rood, P. J. T. van de Schoor, F. van Tertholen, K. Pickkers, P. van den Boogaard, M. | J Crit Care | 2019 |
Critical care |
The Role of Delirium and Other Risk Factors on Mortality in Elderly Patients with Critical Limb Ischemia Undergoing Major Lower Limb Amputation | Roijers, J. P. Hopmans, C. J. Janssen, T. L. Mulder, P. G. H. Buimer, M. G. Ho, G. H. de Groot, H. G. W. Veen, E. J. van der Laan, L. | Ann Vasc Surg | 2019 | |
Antipsychotics for preventing delirium in hospitalized adults a systematic review | Oh, E. S. Needham, D. M. Nikooie, R. Wilson, L. M. Zhang, A. Robinson, K. A. Neufeld, K. J. | Annals of Internal Medicine | 2019 |
neuroleptic agent |
Antipsychotics for treating delirium in hospitalized adults a systematic review | Nikooie, R. Neufeld, K. J. Oh, E. S. Wilson, L. M. Zhang, A. Robinson, K. A. Needham, D. M. | Annals of Internal Medicine | 2019 |
amisulpride |
Exploiting Machine Learning Algorithms and Methods for the Prediction of Agitated Delirium After Cardiac Surgery: Models Development and Validation Study | Mufti, H. N. Hirsch, G. M. Abidi, S. R. Abidi, S. S. R. | JMIR Med Inform | 2019 |
cardiac surgery |
Predictors and prognosis of delirium among older subjects in cardiac intensive care unit: focus on potentially preventable forms | Mossello, E. Baroncini, C. Pecorella, L. Giulietti, C. Chiti, M. Caldi, F. Cavallini, M. C. Simoni, D. Baldasseroni, S. Fumagalli, S. Valoti, P. Stroppa, S. Parenti, K. Ungar, A. Masotti, G. Marchionni, N. Di Bari, M. | Eur Heart J Acute Cardiovasc Care | 2019 |
*Delirium |
Dysfunction of the blood-brain barrier in postoperative delirium patients, referring to the axonal damage biomarker phosphorylated neurofilament heavy subunit | Mietani, K. Sumitani, M. Ogata, T. Shimojo, N. Inoue, R. Abe, H. Kawamura, G. Yamada, Y. | PLoS One | 2019 | |
The 4 ‘a’s test for detecting delirium in acute medical patients: A diagnostic accuracy study | Maclullich, A. M. J. Shenkin, S. D. Goodacre, S. Godfrey, M. Hanley, J. Stíobhairt, A. Lavender, E. Boyd, J. Stephen, J. Weir, C. Macraild, A. Steven, J. Black, P. Diernberger, K. Hall, P. Tieges, Z. Fox, C. Anand, A. Young, J. Siddiqi, N. Gray, A. | Health Technology Assessment | 2019 |
ISRCTN53388093 |
Initiation and continuation of antipsychotic medicines in older people following non-psychiatric hospital admission | Kalisch Ellett, L. M. Pratt, N. L. Apajee, J. Roughead, E. E. | Int J Clin Pharm | 2019 |
Antipsychotic |
Staged Implementation of Awakening and Breathing, Coordination, Delirium Monitoring and Management, and Early Mobilization Bundle Improves Patient Outcomes and Reduces Hospital Costs | Hsieh, S. J. Otusanya, O. Gershengorn, H. B. Hope, A. A. Dayton, C. Levi, D. Garcia, M. Prince, D. Mills, M. Fein, D. Colman, S. Gong, M. N. | Critical Care Medicine | 2019 |
adult |
The Prevalence of Delirium in An Older Acute Surgical Population and Its Effect on Outcome | Hewitt, J. Owen, S. Carter, B. R. Stechman, M. J. Tay, H. S. Greig, M. McCormack, C. Pearce, L. McCarthy, K. Myint, P. K. Moug, S. J. | Geriatrics | 2019 |
Cognitive impairment |
Care challenges in older general hospital patients : Impact of cognitive impairment and other patient-related factors | Hendlmeier, I. Bickel, H. Hessler-Kaufmann, J. B. Schaufele, M. | Z Gerontol Geriatr | 2019 |
Adverse events |
Efficacy of music on sedation, analgesia and delirium in critically ill patients. A systematic review of randomized controlled trials | Garcia Guerra, G. Almeida, L. Zorzela, L. King-Jones, S. Joffe, A. R. Hartling, L. Jou, H. Vohra, S. | J Crit Care | 2019 |
Analgesia |
Postoperative Pressure Ulcers After Geriatric Hip Fracture Surgery Are Predicted by Defined Preoperative Comorbidities and Postoperative Complications | Galivanche, A. R. Kebaish, K. J. Adrados, M. Ottesen, T. D. Varthi, A. G. Rubin, L. E. Grauer, J. N. | The Journal of the American Academy of Orthopaedic Surgeons | 2019 |
adult |
The Healthy Heart-Mind Trial: Randomized Controlled Trial of Melatonin for Prevention of Delirium | Ford, A. H. Flicker, L. Kelly, R. Patel, H. Passage, J. Wibrow, B. Anstey, M. Edwards, M. Almeida, O. P. | J Am Geriatr Soc | 2019 |
cardiothoracic |
The Caregiver Burden of Delirium in Older Adults With Alzheimer Disease and Related Disorders | Fong, T. G. Racine, A. M. Fick, D. M. Tabloski, P. Gou, Y. Schmitt, E. M. Hshieh, T. T. Metzger, E. Bertrand, S. E. Marcantonio, E. R. Jones, R. N. Inouye, S. K. | J Am Geriatr Soc | 2019 |
Alzheimer disease |
Geriatric Events Among Older Adults Undergoing Nonelective Surgery Are Associated with Poor Outcomes | Dworsky, J. Q. Childers, C. P. Copeland, T. Maggard-Gibbons, M. Tan, H. J. Saliba, D. Russell, M. M. | Am Surg | 2019 | |
Shifting the focus: A QI project to improve the management of delirium in patients with hip fracture | Dormandy, L. Mufti, S. Higgins, E. Bailey, C. Dixon, M. | Future Healthc J | 2019 |
Neck of femur fracture |
Impact of a delirium prevention project among older hospitalized patients who underwent orthopedic surgery: a retrospective cohort study | Choi, J. Y. Kim, K. I. Kang, M. G. Lee, Y. K. Koo, K. H. Oh, J. H. Park, Y. H. Suh, J. Kim, N. H. Yoo, H. J. Koo, J. Moon, H. M. Kim, E. H. Park, K. Kim, C. H. | BMC Geriatr | 2019 |
Delirium |
Melatonin for the prevention of postoperative delirium in older adults: a systematic review and meta-analysis | Campbell, A. M. Axon, D. R. Martin, J. R. Slack, M. K. Mollon, L. Lee, J. K. | BMC Geriatr | 2019 |
Delirium |
Assessment of a Geriatric Hip Fracture Program: Analysis of Harmful Adverse Events Using the Global Trigger Tool | Blood, T. D. Deren, M. E. Goodman, A. D. Hayda, R. A. Trafton, P. G. | Journal of Bone and Joint Surgery - American Volume | 2019 |
acute blood loss anemia |
Clinical management of delirium: The response depends on the subtypes. An observational cohort study in 602 patients | Zipser, C. M. Knoepfel, S. Hayoz, P. Schubert, M. Ernst, J. von Kanel, R. Boettger, S. | Palliat Support Care | 2019 |
Antipsychotics |
Predisposing and precipitating factors for delirium in neurology: a prospective cohort study of 1487 patients | Zipser, C. M. Deuel, J. Ernst, J. Schubert, M. Weller, M. von Kanel, R. Boettger, S. | J Neurol | 2019 |
Delirium |
Risk factors for postoperative delirium after spinal surgery: a systematic review and meta-analysis | Zhu, C. Wang, B. Yin, J. Xue, Q. Gao, S. Xing, L. Wang, H. Liu, W. Liu, X. | Aging Clin Exp Res | 2019 |
Delirium |
Dexmedetomidine for the prevention of postoperative delirium in elderly patients undergoing noncardiac surgery: A meta-analysis of randomized controlled trials | Zeng, H. Li, Z. He, J. Fu, W. | PLoS One | 2019 | |
Risk factors for delirium: Are therapeutic interventions part of it? | Xing, J. Yuan, Z. Jie, Y. Liu, Y. Wang, M. Sun, Y. | Neuropsychiatric Disease and Treatment | 2019 |
arterial line |
Intraoperative hyperglycemia increases the incidence of postoperative delirium | Windmann, V. Spies, C. Knaak, C. Wollersheim, T. Piper, S. K. Vorderwulbecke, G. Kurpanik, M. Kuenz, S. Lachmann, G. | Minerva Anestesiol | 2019 | |
External Validation of Two Models to Predict Delirium in Critically Ill Adults Using Either the Confusion Assessment Method-ICU or the Intensive Care Delirium Screening Checklist for Delirium Assessment | Wassenaar, A. Schoonhoven, L. Devlin, J. W. van Haren, F. M. P. Slooter, A. J. C. Jorens, P. G. van der Jagt, M. Simons, K. S. Egerod, I. Burry, L. D. Beishuizen, A. Matos, J. Donders, A. R. T. Pickkers, P. van den Boogaard, M. | Crit Care Med | 2019 |
adult |
Risk Factors and Incidence of Postoperative Delirium in Patients Undergoing Laryngectomy | Wang, Y. Yu, H. Qiao, H. Li, C. Chen, K. Shen, X. | Otolaryngol Head Neck Surg | 2019 |
head and neck cancer |
Regional cerebral oxygen saturation and postoperative delirium in endovascular surgery: a prospective cohort study | Wang, X. Feng, K. Liu, H. Liu, Y. Ye, M. Zhao, G. Wang, T. | Trials | 2019 |
Delirium |
The impact of analgosedation on mortality and delirium in critically ill patients: A systematic review and meta-analysis | Wang, C. T. Mao, Y. Zhao, L. Ma, B. | Intensive Crit Care Nurs | 2019 |
Analgesia-based sedation |
Incidence and risk factors of postoperative delirium in patients admitted to the ICU after elective intracranial surgery: A prospective cohort study | Wang, C. M. Huang, H. W. Wang, Y. M. He, X. Sun, X. M. Zhou, Y. M. Zhang, G. B. Gu, H. Q. Zhou, J. X. | Eur J Anaesthesiol | 2019 | |
Association between preoperative nutritional status and postoperative delirium in individuals with coronary artery bypass graft surgery: A prospective cohort study | Velayati, A. Vahdat Shariatpanahi, M. Shahbazi, E. Vahdat Shariatpanahi, Z. | Nutrition | 2019 |
adductor pollicis muscle |
Prevalence and risk factors for delirium in elderly patients with severe burns: a retrospective cohort study | van Yperen, D. T. Raats, J. W. Dokter, J. Ziere, G. Roukema, G. R. van Baar, M. E. van der Vlies, C. H. | J Burn Care Res | 2019 |
Elderly |
Delirium After Transcatheter Aortic Valve Implantation Under General Anesthesia: Incidence, Predictors, and Relation to Long-Term Survival | van der Wulp, K. van Wely, M. van Heijningen, L. van Bakel, B. Schoon, Y. Verkroost, M. Gehlmann, H. Van Garsse, L. Vart, P. Kievit, P. Rikkert, M. O. Morshuis, W. van Royen, N. | J Am Geriatr Soc | 2019 |
general anesthesia |
Impact of a Premorbid Psychiatric Disorder on the Incidence of Delirium during ICU Stay, Morbidity, and Long-Term Mortality | van der Kuur, A. Bethlehem, C. Bruins, N. de Jager, C. van Alst, C. Haagsma, O. G. Keijzers, A. Boerma, E. C. | Crit Care Res Pract | 2019 | |
Identifying determinants for the application of physical or chemical restraint in the management of psychomotor agitation on the critical care unit | Teece, A. Baker, J. Smith, H. | J Clin Nurs | 2019 |
agitation |
Impact of a nurse engagement intervention on pain, agitation and delirium assessment in a community intensive care unit | Tan, C. M. Camargo, M. Miller, F. Ross, K. Maximous, R. Yung, P. Marshall, C. Fleming, D. Law, M. Tsang, J. L. | BMJ Open Qual | 2019 |
critical care |
Predictors of delirium after cardiac surgery in patients with sleep disordered breathing | Tafelmeier, M. Knapp, M. Lebek, S. Floerchinger, B. Camboni, D. Creutzenberg, M. Wittmann, S. Zeman, F. Schmid, C. Maier, L. S. Wagner, S. Arzt, M. | Eur Respir J | 2019 | |
The relationship between obstructive sleep apnoea and postoperative delirium and pain: an observational study of a surgical cohort | Strutz, P. K. Kronzer, V. Tzeng, W. Arrington, B. McKinnon, S. L. Ben Abdallah, A. Haroutounian, S. Avidan, M. S. | Anaesthesia | 2019 |
delirium |
Ultra-brief Screeners for Detecting Delirium Superimposed on Dementia | Steensma, E. Zhou, W. Ngo, L. Gallagher, J. Inouye, S. Leslie, D. Boltz, M. Kolanowski, A. Mion, L. Marcantonio, E. R. Fick, D. | J Am Med Dir Assoc | 2019 |
Delirium |
Etiology and Related Factors of Postoperative Delirium in Orthopedic Surgery | Song, K. J. Ko, J. H. Kwon, T. Y. Choi, B. W. | Clin Orthop Surg | 2019 |
Delirium |
Preoperative transcranial Doppler and cerebral oximetry as predictors of delirium following valvular heart surgery: a case-control study | Soh, S. Shim, J. K. Song, J. W. Choi, N. Kwak, Y. L. | J Clin Monit Comput | 2019 |
Cardiac surgical procedures |
Identification of Patients With High Mortality Risk and Prediction of Outcomes in Delirium by Bispectral EEG | Shinozaki, G. Bormann, N. L. Chan, A. C. Zarei, K. Sparr, N. A. Klisares, M. J. Jellison, S. S. Heinzman, J. T. Dahlstrom, E. B. Duncan, G. N. Gaul, L. N. Wanzek, R. J. Cramer, E. M. Wimmel, C. G. Sabbagh, S. Yuki, K. Weckmann, M. T. Yamada, T. Karam, M. | J Clin Psychiatry | 2019 | |
Postoperative Delirium Is Associated with Long-term Decline in Activities of Daily Living | Shi, Z. Mei, X. Li, C. Chen, Y. Zheng, H. Wu, Y. Zheng, H. Liu, L. Marcantonio, E. R. Xie, Z. Shen, Y. | Anesthesiology | 2019 | |
Managing Delirium and Agitation in the Older Emergency Department Patient: The ADEPT Tool | Shenvi, C. Kennedy, M. Austin, C. A. Wilson, M. P. Gerardi, M. Schneider, S. | Ann Emerg Med | 2019 | |
Delirium detection in older acute medical inpatients: a multicentre prospective comparative diagnostic test accuracy study of the 4AT and the confusion assessment method | Shenkin, S. D. Fox, C. Godfrey, M. Siddiqi, N. Goodacre, S. Young, J. Anand, A. Gray, A. Hanley, J. MacRaild, A. Steven, J. Black, P. L. Tieges, Z. Boyd, J. Stephen, J. Weir, C. J. MacLullich, A. M. J. | BMC Med | 2019 |
*4at |
Occurrence Rate of Delirium in Acute Stroke Settings: Systematic Review and Meta-Analysis | Shaw, R. C. Walker, G. Elliott, E. Quinn, T. J. | Stroke | 2019 |
delirium |
Delirium in an Acute Stroke Setting, Occurrence, and Risk Factors | Shaw, R. Drozdowska, B. Taylor-Rowan, M. Elliott, E. Cuthbertson, G. Stott, D. J. Quinn, T. J. | Stroke | 2019 |
cognitive dysfunction |
The relationship between serum cobalamin, folic acid, and homocysteine and the risk of post-cardiac surgery delirium | Shariatpanahi, M. V. Velayati, A. Jamalian, S. A. Babevaynejad, M. Shariatpanahi, Z. V. | Neuropsychiatric Disease and Treatment | 2019 |
cobalamin |
The effect of volunteers' care and support on the health outcomes of older adults in acute care: A systematic scoping review | Saunders, R. Seaman, K. Graham, R. Christiansen, A. | J Clin Nurs | 2019 |
Volunteers |
Mitochondrial DNA Haplogroups and Delirium During Sepsis | Samuels, D. C. Hulgan, T. Fessel, J. P. Billings, F. T. th Thompson, J. L. Chandrasekhar, R. Girard, T. D. | Crit Care Med | 2019 | |
Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial | Rosa, R. G. Falavigna, M. da Silva, D. B. Sganzerla, D. Santos, M. M. S. Kochhann, R. de Moura, R. M. Eugenio, C. S. Haack, Tdsr Barbosa, M. G. Robinson, C. C. Schneider, D. de Oliveira, D. M. Jeffman, R. W. Cavalcanti, A. B. Machado, F. R. Azevedo, L. C. | JAMA | 2019 |
Anxiety |
Deconstructing Poststroke Delirium in a Prospective Cohort of Patients With Intracerebral Hemorrhage | Reznik, M. E. Drake, J. Margolis, S. A. Moody, S. Murray, K. Costa, S. Mahta, A. Wendell, L. C. Thompson, B. B. Rao, S. S. Barrett, A. M. Boukrina, O. Daiello, L. A. Asaad, W. F. Furie, K. L. Jones, R. N. | Crit Care Med | 2019 | |
Impact of intraoperative blood pressure, blood pressure fluctuation, and pulse pressure on postoperative delirium in elderly patients with hip fracture: A prospective cohort study | Radinovic, K. Markovic Denic, L. Milan, Z. Cirkovic, A. Baralic, M. Bumbasirevic, V. | Injury | 2019 |
Blood pressure |