What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Off-label use of quetiapine in nursing homes: Does medical specialty of prescribing physicians play a role? | Müller, L. Noseda, R. Bertoli, R. Bissig, M. Ceschi, A. | British Journal of Clinical Pharmacology | 2020 |
quetiapine |
| Multidisciplinary quality improvement programme for older patients admitted to a vascular surgery ward() | Mudge, A. M. McRae, P. Donovan, P. J. Reade, M. C. | Intern Med J | 2020 |
delirium |
| Cross-cultural adaptation and validation of the 3D-CAM Chinese version in surgical ICU patients | Mu, D. L. Ding, P. P. Zhou, S. Z. Liu, M. J. Sun, X. Y. Li, X. Y. Wang, D. X. | BMC Psychiatry | 2020 |
3d-cam |
| Thiamine for Prevention of Postoperative Delirium in Patients Undergoing Gastrointestinal Surgery: A Randomized Clinical Trial | Moslemi, R. Khalili, H. Mohammadi, M. Mehrabi, Z. Mohebbi, N. | J Res Pharm Pract | 2020 |
Delirium |
| How successful are we in relieving terminal dyspnea in cancer patients? A real-world multicenter prospective observational study | Mori, M. Morita, T. Matsuda, Y. Yamada, H. Kaneishi, K. Matsumoto, Y. Matsuo, N. Odagiri, T. Aruga, E. Watanabe, H. Tatara, R. Sakurai, H. Kimura, A. Katayama, H. Suga, A. Nishi, T. Shirado, A. N. Watanabe, T. Kuchiba, A. Yamaguchi, T. Iwase, S. | Supportive Care in Cancer | 2020 | |
| Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia | Morandi, A. Zambon, A. Di Santo, S. G. Mazzone, A. Cherubini, A. Mossello, E. Bo, M. Marengoni, A. Bellelli, G. | Journal of the American Medical Directors Association | 2020 |
intravenous catheter |
| Infection in older adults: a qualitative study of patient experience | Moore, A. McKelvie, S. Glogowska, M. Lasserson, D. Hayward, G. | Br J Gen Pract | 2020 |
aged |
| Aripiprazole for prevention of delirium in the neurosurgical intensive care unit: a double-blind, randomized, placebo-controlled study | Mokhtari, M. Farasatinasab, M. Jafarpour Machian, M. Yaseri, M. Ghorbani, M. Ramak Hashemi, S. M. Nikoobakht, M. Golchin, N. Mohammadi, G. Sistanizad, M. | Eur J Clin Pharmacol | 2020 |
Aripiprazole |
| Potentially Inappropriate Medications in a Psychogeriatric Inpatient Ward: An Audit Based on Beers Criteria | Moebs, I. Abeln, E. Siefert, A. Barak, Y. | Neurology and Therapy | 2020 |
adult |
| An 11-year review of hip fracture hospitalisations, health outcomes, and predictors of access to in-hospital rehabilitation for adults ≥ 65 years living with and without dementia: a population-based cohort study | Mitchell, R. Draper, B. Brodaty, H. Close, J. Ting, H. P. Lystad, R. Harris, I. Harvey, L. Sherrington, C. Cameron, I. D. Braithwaite, J. | Osteoporos Int | 2020 |
Aged care |
| Evaluation of a co-produced delirium awareness programme for undergraduate nursing students in Northern Ireland: a pre-test/post-test study | Mitchell, G. McVeigh, C. Carlisle, S. Brown-Wilson, C. | BMC Nurs | 2020 |
Co-design |
| Perioperative dexmedetomidine and postoperative delirium in non-cardiac surgery: a meta-analysis | Ming, S. Zhang, X. Gong, Z. Xie, Y. Xie, Y. | Ann Palliat Med | 2020 |
Dexmedetomidine |
| Cholinesterases and Anticholinergic Medications in Postoperative Pediatric Delirium | Meyburg, J. Ritsert, M. L. Traube, C. Plaschke, K. von Haken, R. | Pediatr Crit Care Med | 2020 | |
| Comparison of novel tools with traditional cognitive tests in detecting delirium in elderly medical patients | Meagher, D. J. O'Connell, H. Leonard, M. Williams, O. Awan, F. Exton, C. Tenorio, M. O'Connor, M. Dunne, C. P. Cullen, W. McFarland, J. Adamis, D. | World J Psychiatry | 2020 |
Assessment |
| A systematic review and meta-analysis of the accuracy of the clock drawing test (CDT) in the identification of delirium in older hospitalised patients | Meagher, D. Williams, O. A. O'Connell, H. Leonard, M. Cullen, W. Dunne, C. P. Mulligan, O. Adamis, D. | Aging & mental health | 2020 |
adult |
| Family intervention improves outcomes for patients with delirium: Systematic review and meta-analysis | McKenzie, J. Joy, A. | Australas J Ageing | 2020 |
caregivers |
| Effectiveness and Safety of Intrathecal Ziconotide: Final Results of the Patient Registry of Intrathecal Ziconotide Management (PRIZM) | McDowell, G. C. Saulino, M. F. Wallace, M. Grigsby, E. J. Rauck, R. L. Kim, P. Vanhove, G. F. Ryan, R. Huang, I. Z. Deer, T. | Pain medicine (Malden, Mass.) | 2020 |
adult |
| Management Effort for Delirium and Insomnia in Patients with Acute Ischemic Stroke (MEDIAS) Study | Matsuzono, K. Mashiko, T. Ozawa, T. Miura, K. Suzuki, M. Furuya, K. Ozawa, M. Anan, Y. Shimazaki, H. Koide, R. Tanaka, R. Fujimoto, S. | Psychiatry Clin Neurosci | 2020 | |
| High Prevalence of Oropharyngeal Dysphagia in Acutely Hospitalized Patients Aged 80 Years and Older | Mateos-Nozal, J. Montero-Errasquín, B. Sánchez García, E. Romero Rodríguez, E. Cruz-Jentoft, A. J. | J Am Med Dir Assoc | 2020 |
Dysphagia |
| Dexmedetomidine in medical cardiac intensive care units. Data from a multicenter prospective registry | Mateos Gaitan, R. Vicent, L. Rodriguez-Queralto, O. Lopez-de-Sa, E. Elorriaga, A. Pastor, G. Bañeras, J. Lorenzo, B. García-Rubira, J. C. Corbi, M. Ariza, A. Martínez-Sellés, M. | Int J Cardiol | 2020 |
Adverse effects |
| Myocardial Function in Patients With Radiation-Associated Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: A Layer-Specific Strain Analysis Study | Martinez, C. Cicenia, M. Sprynger, M. Postolache, A. Ilardi, F. Dulgheru, R. Radermecker, M. Esposito, G. Marechal, P. Marechal, V. Donis, N. Tridetti, J. Nguyen Trung, M. L. Sugimoto, T. Tsugu, T. Go, Y. Y. Coisne, A. Montaigne, D. Fattouch, K. Nchimi, A | JACC: Cardiovascular Imaging | 2020 |
CoreValve self-expandable biologic prosthesis |
| Prevalence and clinical correlates of non-convulsive status epilepticus in elderly patients with acute confusional state: A systematic literature review | Manfredonia, F. Saturno, E. Lawley, A. Gasverde, S. Cavanna, A. E. | J Neurol Sci | 2020 |
Acute confusional state |
| Downstream consequences of abnormal cognitive screening in older adults seen pretreatment in a geriatric oncology clinic | Malik, U. Alam, Z. Loucks, A. Jin, R. Yokom, D. Watt, S. Berger, A. Romanovsky, L. Puts, M. Alibhai, S. M. H. | J Geriatr Oncol | 2020 |
Cognitive impairment |
| A Study of the Psychometric Properties of the "Stanford Proxy Test for Delirium" (S-PTD): A New Screening Tool for the Detection of Delirium | Maldonado, J. R. Sher, Y. I. Benitez-Lopez, M. A. Savant, V. Garcia, R. Ament, A. De Guzman, E. | Psychosomatics | 2020 |
S-ptd |
| Family Identification of Delirium in the Emergency Department in Patients With and Without Dementia: Validity of the Family Confusion Assessment Method (FAM-CAM) | Mailhot, T. Darling, C. Ela, J. Malyuta, Y. Inouye, S. K. Saczynski, J. | J Am Geriatr Soc | 2020 |
Fam-cam |
| Frailty Is Associated With Postoperative Delirium But Not With Postoperative Cognitive Decline in Older Noncardiac Surgery Patients | Mahanna-Gabrielli, E. Zhang, K. Sieber, F. E. Lin, H. M. Liu, X. Sewell, M. Deiner, S. G. Boockvar, K. S. | Anesth Analg | 2020 |
Aged |
| 2019-NCoV: What every neurologist should know? | Mahajan, N. Singla, M. Singh, B. Sajja, V. Bansal, P. Paul, B. Goel, P. Midha, R. Bansal, R. Singh, G. | Annals of Indian Academy of Neurology | 2020 |
alanine aminotransferase |
| Age, Comorbidities and Fear of Fall: mortality predictors associated with fall-related fractures | Magdalini, V. Petros, I. Constantinos, T. Garyfalia, S. P. Emmanouil, P. Christos, K. George, K. Kalliopi, A. George, S. Symeon, H. P. | Maedica (Buchar) | 2020 | |
| Stress-Induced Behavioral Quiescence and Abnormal Rest-Activity Rhythms During Critical Illness | Maas, M. B. Lizza, B. D. Kim, M. Abbott, S. M. Gendy, M. Reid, K. J. Zee, P. C. | Crit Care Med | 2020 | |
| Incidence and risk factors of delirium in icu patients | Ma, W. Zheng, J. Xu, S. Huo, Z. | International Journal of Clinical and Experimental Medicine | 2020 |
stomach tube |
| Age, preoperative higher serum cortisol levels, and lower serum acetylcholine levels predict delirium after percutaneous coronary intervention in acute coronary syndrome patients accompanied with renal dysfunction | Ma, J. Fan, M. Wang, Z. | Indian Journal of Psychiatry | 2020 |
IE33 |
| Non-Pharmacologic Multicomponent Interventions Preventing Delirium in Hospitalized People | Ludolph, P. Stoffers-Winterling, J. Kunzler, A. M. Rösch, R. Geschke, K. Vahl, C. F. Lieb, K. | J Am Geriatr Soc | 2020 |
delirium |
| Usefulness of postoperative serum translocator protein as a predictive marker for delirium after breast cancer surgery in elderly women | Lu, G. W. Chou, Y. E. Jin, W. L. Su, X. B. | J Int Med Res | 2020 |
Translocator protein |
| Characteristics, Symptom Management, and Outcomes of 101 Patients With COVID-19 Referred for Hospital Palliative Care | Lovell, N. Maddocks, M. Etkind, S. N. Taylor, K. Carey, I. Vora, V. Marsh, L. Higginson, I. J. Prentice, W. Edmonds, P. Sleeman, K. E. | J Pain Symptom Manage | 2020 |
Covid-19 |
| Characterisation of ICU sleep by a commercially available activity tracker and its agreement with patient-perceived sleep quality | Louzon, P. Andrews, J. Torres, X. Pyles, E. Ali, M. Du, Y. Devlin, J. | BMJ Open Respir Res | 2020 |
equipment evaluations |
| Surgical treatment of hip fracture in centenarians: Complications and independent risk factors of death | López, Torres, II Sanz-Ruiz, P. Montero-Fernández, N. Chana, F. Serra-Rexach, J. A. Benjumea-Carrasco, A. Vaquero-Martín, J. | Injury | 2020 |
Centenarians |
| Long-term survival of femoral neck fracture patients aged over ninety years: Arthroplasty compared with nonoperative treatment | Liu, Y. Zhang, C. W. Zhao, X. D. | BMC Musculoskeletal Disorders | 2020 |
albumin |
| Subjective memory complaints predict poorer functional recovery during the first year following hip-fracture surgery among elderly adults | Liu, H. Y. Wang, H. P. Chen, C. Y. Wu, C. C. Hua, M. S. Lin, Y. E. Lin, Y. C. Shyu, Y. L. | Int J Geriatr Psychiatry | 2020 |
hip fracture |
| Delirium Severity Trajectories and Outcomes in ICU Patients: Defining a Dynamic Symptom Phenotype | Lindroth, H. Khan, B. A. Carpenter, J. S. Gao, S. Perkins, A. J. Khan, S. H. Wang, S. Jones, R. N. Boustani, M. A. | Ann Am Thorac Soc | 2020 | |
| Early mobilisation of ventilated patients in the intensive care unit: A survey of critical care clinicians in an Australian tertiary hospital | Lin, F. Phelan, S. Chaboyer, W. Mitchell, M. | Aust Crit Care | 2020 |
Attitudes |
| Perioperative Dexmedetomidine Supplement Decreases Delirium Incidence After Adult Cardiac Surgery: A Randomized, Double-Blind, Controlled Study | Likhvantsev, V. V. Landoni, G. Grebenchikov, O. A. Ovezov, A. M. Skripkin, Y. V. Lembo, R. Gaevskiy, D. I. Tereshina, A. A. Yavorovskiy, A. G. | Journal of Cardiothoracic and Vascular Anesthesia | 2020 |
adult |
| Derivation and Validation of a Risk Stratification System for Predicting Postoperative Cognitive Impairment | Liao, Y. Su, X. Ouyang, W. Li, L. Chen, S. Chou, J. Le, Y. | J Invest Surg | 2020 |
Postoperative cognitive dysfunction |
| Effects of anesthesia depth on postoperative cognitive function and inflammation: a systematic review and meta-analysis | Li, Y. Zhang, B. | Minerva Anestesiol | 2020 | |
| Prevalence, outcome and prognostic factors of neuropsychiatric systemic lupus erythematosus: A real world single center study | Li, X. Xiang, X. Sun, J. Liu, S. Liu, Y. Feng, L. Li, C. Li, Z. | Mod Rheumatol | 2020 |
Neuropsychiatric systemic lupus erythematosus |
| Postoperative Delirium Following Joint Replacement in Patients With Dementia in New South Wales, Australia: A State-Wide Retrospective Cohort Study | Li, X. Du, W. Parkinson, A. Glasgow, N. | Research in gerontological nursing | 2020 |
adult |
| Effect of dexmedetomidine on prevention of postoperative nausea and vomiting in pediatric strabismus surgery: a randomized controlled study | Li, S. Liu, T. Xia, J. Jia, J. Li, W. | BMC Ophthalmol | 2020 |
Dexmedetomidine |
| Toxicity and survival outcomes of autologous stem cell transplant in multiple myeloma patients with renal insufficiency: an institutional comparison between two eras | Li, A. Y. Atenafu, E. G. Bernard, R. S. Masih-Khan, E. Reece, D. Franke, N. Tiedemann, R. Prica, A. Trudel, S. Kukreti, V. Chen, C. I. | Bone Marrow Transplant | 2020 | |
| Risk Prediction for Adverse Outcomes for Frail Older Persons with Complex Healthcare and Social Care Needs Admitted to a Community Virtual Ward Model | Lewis, C. O'Caoimh, R. Patton, D. O'Connor, T. Moore, Z. Nugent, L. E. | Clin Interv Aging | 2020 |
case management |
| The role of melatonin and melatonin receptor agonist in the prevention of sleep disturbances and delirium in intensive care unit - a clinical review | Lewandowska, K. Małkiewicz, M. A. Siemiński, M. Cubała, W. J. Winklewski, P. J. Mędrzycka-Dąbrowska, W. A. | Sleep Med | 2020 |
Delirium |
| Neurological manifestations associated with COVID-19: a review and a call for action | Leonardi, M. Padovani, A. McArthur, J. C. | Journal of Neurology | 2020 |
acroparesthesia |
| "You've got to keep moving, keep going": Understanding older patients' experiences and perceptions of delirium and nonpharmacological delirium prevention strategies in the acute hospital setting | Lee-Steere, K. Liddle, J. Mudge, A. Bennett, S. McRae, P. Barrimore, S. E. | J Clin Nurs | 2020 |
adult |
| The effect of dexmedetomidine on postoperative behaviour change in children: a randomised controlled trial | Lee-Archer, P. F. von Ungern-Sternberg, B. S. Reade, M. Betts, M. Haenke, D. Keys, A. Rance, T. Gibbons, K. Long, D. | Anaesthesia | 2020 |
behaviour changes |
| Developing delirium best practice: a systematic review of education interventions for healthcare professionals working in inpatient settings | Lee, S. Y. Fisher, J. Wand, A. P. F. Milisen, K. Detroyer, E. Sockalingam, S. Agar, M. Hosie, A. Teodorczuk, A. | European Geriatric Medicine | 2020 |
behavior change |
| Outcomes of the Extreme Elderly Undergoing Anaesthesia and Surgery amongst Southeast Asians | Lee, S. J. Ng, O. Thong, S. Y. | Anesthesiology Research and Practice | 2020 |
dynamic hip screw |
| Predictors of New-Onset Physical Restraint Use in Critically Ill Adults | Lawson, T. N. Tan, A. Thrane, S. E. Happ, M. B. Mion, L. C. Tate, J. Balas, M. C. | Am J Crit Care | 2020 | |
| Decision-making for older patients undergoing emergency laparotomy: defining patient and clinician values and priorities | Law, J. Welch, C. Javanmard-Emamghissi, H. Clark, M. Bisset, C. N. O'Neil, P. Moug, S. J. | Colorectal Dis | 2020 |
Emergency laparotomy |
| Delirium prevalence and prevention in patients with acute brain injury: A prospective before-and-after intervention study | Larsen, L. K. Møller, K. Petersen, M. Egerod, I. | Intensive & critical care nursing | 2020 |
adult |
| Comparison of Hydromorphone versus Fentanyl-based Sedation in Extracorporeal Membrane Oxygenation: A Propensity-Matched Analysis | Landolf, K. M. Rivosecchi, R. M. Goméz, H. Sciortino, C. M. Murray, H. N. Padmanabhan, R. R. Sanchez, P. G. Harano, T. Sappington, P. L. | Pharmacotherapy | 2020 |
acute respiratory distress syndrome |
| Collaborative Delirium Prevention in the Age of COVID-19 | LaHue, S. C. James, T. C. Newman, J. C. Esmaili, A. M. Ormseth, C. H. Ely, E. W. | J Am Geriatr Soc | 2020 |
Aged |
| Intra-operative hyperoxia and the risk of delirium in elderly patients after cardiac surgery | Kupiec, A. Adamik, B. Forkasiewicz-Gardynik, K. Goździk, W. | Aging (Albany NY) | 2020 |
cardiac surgery |
| Clinical profile and predictor of adverse outcome in children with acute encephalitis syndrome: A cross-sectional study | Kuntal, M. Swarnkar, K. | Journal of Krishna Institute of Medical Sciences University | 2020 |
immunoglobulin M |
| Intraoperative Optimization of Both Depth of Anesthesia and Cerebral Oxygenation in Elderly Patients Undergoing Coronary Artery Bypass Graft Surgery-A Randomized Controlled Pilot Trial | Kunst, G. Gauge, N. Salaunkey, K. Spazzapan, M. Amoako, D. Ferreira, N. Green, D. W. Ballard, C. | J Cardiothorac Vasc Anesth | 2020 |
cardiac anesthesia |
| Establishment of an enhanced recovery after surgery protocol in minimally invasive heart valve surgery | Kubitz, J. C. Schulte-Uentrop, L. Zoellner, C. Lemke, M. Messner-Schmitt, A. Kalbacher, D. Sill, B. Reichenspurner, H. Koell, B. Girdauskas, E. | PLoS One | 2020 | |
| Preoperative cognitive impairment associated with oversedation during recovery from anesthesia | Kruthiventi, S. C. Laporta, M. L. Deljou, A. Knopman, D. S. Petersen, R. C. Schroeder, D. R. Sprung, J. Weingarten, T. N. | J Anesth | 2020 |
Anesthesia |
| Non-contact monitoring of agitation and use of a sheltering device in patients with dementia in emergency departments: a feasibility study | Kroll, L. Böhning, N. Müßigbrodt, H. Stahl, M. Halkin, P. Liehr, B. Grunow, C. Kujumdshieva-Böhning, B. Freise, C. Hopfenmüller, W. Friesdorf, W. Jockers-Scherübl, M. Somasundaram, R. | BMC Psychiatry | 2020 |
Dementia, agitation |
| COVID-19: ICU delirium management during SARS-CoV-2 pandemic | Kotfis, K. Williams Roberson, S. Wilson, J. E. Dabrowski, W. Pun, B. T. Ely, E. W. | Crit Care | 2020 |
Betacoronavirus |
| COVID-19: What do we need to know about ICU delirium during the SARS-CoV-2 pandemic? | Kotfis, K. Williams Roberson, S. Wilson, J. Pun, B. Ely, E. W. Jeżowska, I. Jezierska, M. Dabrowski, W. | Anaesthesiol Intensive Ther | 2020 |
Pics |
| The impact of acute kidney injury in the perioperative period on the incidence of postoperative delirium in patients undergoing coronary artery bypass grafting—observational cohort study | Kotfis, K. Ślozowska, J. Listewnik, M. Szylińska, A. Rotter, I. | International Journal of Environmental Research and Public Health | 2020 |
creatinine |
| Association between Preoperative Obstructive Sleep Apnea and Preoperative Positive Airway Pressure with Postoperative Intensive Care Unit Delirium | King, C. R. Fritz, B. A. Escallier, K. Ju, Y. E. S. Lin, N. McKinnon, S. Avidan, M. S. Palanca, B. J. | JAMA Network Open | 2020 |
adult |
| Risk factors and outcomes of sepsis-associated delirium in intensive care unit patients: A secondary data analysis | Kim, Y. Jin, Y. Jin, T. Lee, S. M. | Intensive Crit Care Nurs | 2020 |
Delirium |
| Factors affecting the post-anesthetic recovery score and length of stay in the recovery room in elderly patients with hypertension | Kim, S. Kwon, M. | Medico-Legal Update | 2020 |
aged |
| Comparative efficacy and acceptability of pharmacological interventions for the treatment and prevention of delirium: A systematic review and network meta-analysis | Kim, M. S. Rhim, H. C. Park, A. Kim, H. Han, K. M. Patkar, A. A. Pae, C. U. Han, C. | J Psychiatr Res | 2020 |
Antipsychotics |
| Pre-operative hemoglobin level and use of sedative-hypnotics are independent risk factors for post-operative delirium following total knee arthroplasty | Kijima, E. Kayama, T. Saito, M. Kurosaka, D. Ikeda, R. Hayashi, H. Kubota, D. Hyakutake, T. Marumo, K. | BMC Musculoskelet Disord | 2020 |
Anemia |
| Decreasing Delirium Through Music: A Randomized Pilot Trial | Khan, S. H. Xu, C. Purpura, R. Durrani, S. Lindroth, H. Wang, S. Gao, S. Heiderscheit, A. Chlan, L. Boustani, M. Khan, B. A. | Am J Crit Care | 2020 | |
| Time trends of delirium rates in the intensive care unit | Khan, S. H. Lindroth, H. Hendrie, K. Wang, S. Imran, S. Perkins, A. J. Gao, S. Vahidy, F. S. Boustani, M. Khan, B. A. | Heart Lung | 2020 |
Delirium |
| Neurological complications in recipients after living donor liver transplantation | Khalil, M. Elbanhawy, I. Elsherbiny, A. Amer, H. Ahmed, S. | Neurology India | 2020 |
ammonia |
| International drive to illuminate delirium: A developing public health blueprint for action | Khachaturian, A. S. Hayden, K. M. Devlin, J. W. Fleisher, L. A. Lock, S. L. Cunningham, C. Oh, E. S. Fong, T. G. Fick, D. M. Marcantonio, E. R. Iyengar, V. Rockwood, K. Kuchel, G. A. Eckenhoff, R. G. MacLullich, A. M. J. Jones, R. N. Davis, D. D'Antonio, | Alzheimers Dement | 2020 | |
| Relationship Between Delirium and Ventilatory Outcomes in the Medical Intensive Care Unit | Kerber, K. Zangmeister, J. McNett, M. | Crit Care Nurse | 2020 | |
| Delirium after cardiac arrest: Phenotype, prediction, and outcome | Keijzer, H. M. Klop, M. van Putten, M. J. A. M. Hofmeijer, J. | Resuscitation | 2020 |
clonazepam |
| Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium | Kealy, J. Murray, C. Griffin, E. W. Lopez-Rodriguez, A. B. Healy, D. Tortorelli, L. S. Lowry, J. P. Watne, L. O. Cunningham, C. | J Neurosci | 2020 | |
| Incidental Durotomy is Associated with Increased Risk of Delirium in Patients Aged 65 and Older | Kazarian, E. R. Lopez, W. Y. Eizember, S. Blucher, J. A. Culley, D. J. Javedan, H. Kang, J. D. Schoenfeld, A. J. | Spine (Phila Pa 1976) | 2020 | |
| Scheduled intravenous acetaminophen versus nonsteroidal anti-inflammatory drugs (NSAIDs) for better short-term outcomes after esophagectomy for esophageal cancer | Kawakami, J. Abe, T. Higaki, E. Hosoi, T. Fukaya, M. Komori, K. Ito, S. Nakatochi, M. Nagino, M. Shimizu, Y. | Surg Today | 2020 |
Esophageal surgery |
| Experience of morphine therapy for refractory dyspnea as palliative care in advanced heart failure patients | Kawaguchi, J. Hamatani, Y. Hirayama, A. Nishimura, K. Nakai, E. Nakamura, E. Miyata, M. Kawano, Y. Takada, Y. Anchi, Y. Funabashi, S. Kuroda, K. Azechi, M. Takahama, H. Anzai, T. Yasuda, S. Kitaoka, H. Izumi, C. | J Cardiol | 2020 |
Dyspnea |
| Delirium and Developmental Disability: Improving Specificity of a Pediatric Delirium Screen∗ | Kaur, S. Silver, G. Samuels, S. Rosen, A. H. Weiss, M. Mauer, E. A. Gerber, L. M. Greenwald, B. M. Traube, C. | Pediatric Critical Care Medicine | 2020 |
article |
| Hyperactive Terminal Delirium in Hospice Patients: A Retrospective Cohort Study | Kates, J. | J Hosp Palliat Nurs | 2020 | |
| Incidence & Risk Factors of Postoperative Delirium After Spinal Surgery in Older Patients | Kang, T. Park, S. Y. Lee, J. H. Lee, S. H. Park, J. H. Kim, S. K. Suh, S. W. | Sci Rep | 2020 | |
| C-reactive protein to albumin ratio as a novel inflammatory biomarker for postoperative delirium in patients undergoing transcatheter aortic valve replacement | Kalyoncuoğlu, M. Biter, H. İ Durmuş, G. Baştan, B. Can, M. M. | Haseki Tip Bulteni | 2020 |
biological marker |
| Emergence delirium in children undergoing dental surgery under general anesthesia | Jooma, Z. Perrie, H. Scribante, J. Kleyenstuber, T. | Paediatr Anaesth | 2020 |
Paediatric Anesthesia Emergence Delirium score |
| Alteration of consciousness as initial presentation in COVID-19: Observation | Joob, B. Wiwanitkit, V. | Annals of Indian Academy of Neurology | 2020 |
altered state of consciousness |
| A systematic review of the impact of delirium on allied health interventions: A surprising lack of data | Johnson, D. Maylin, E. Hayes, L. Hair, C. Kraemer, T. Lau, M. Brodtmann, A. Sahathevan, R. | Neurology Asia | 2020 |
arthroplasty |
| Etiology, Clinical Profile and Outcome of Encephalopathy in Elderly | John, B. Loomba, V. John, M. | J Assoc Physicians India | 2020 |
Aged |
| Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial | Jin, L. Yao, R. Heng, L. Pang, B. Sun, F. G. Shen, Y. Zhong, J. F. Zhao, P. P. Wu, C. Y. Li, B. P. | Medicine (Baltimore) | 2020 |
Aged |
| Cognitive Impairment Level and Elderly Hip Fracture: Implications in Rehabilitation Nursing | Jiménez Mola, S. Calvo-Lobo, C. Idoate Gil, J. Seco Calvo, J. | Rehabil Nurs | 2020 | |
| Long-term outcomes of major abdominal surgery and postoperative delirium after multimodal prehabilitation of older patients | Janssen, T. L. Steyerberg, E. W. van Hoof-de Lepper, Ccha Seerden, T. C. J. de Lange, D. C. Wijsman, J. H. Ho, G. H. Gobardhan, P. D. van der Laan, L. | Surg Today | 2020 |
Functional outcomes |
| Young age and severity of motor function are risk factors for psychosis after subthalamic nucleus deep brain stimulation for Parkinson's disease | Ito, M. Sasaki, F. Katsuta, N. Sekimoto, S. Jo, T. Nakamura, R. Nakajima, A. Oyama, G. Shimo, Y. Iwamuro, H. Umemura, A. Ohnuma, T. Hattori, N. | Psychiatry and Clinical Neurosciences | 2020 |
dopamine receptor stimulating agent |
| Impact of frailty and mild cognitive impairment on delirium after cardiac surgery in older patients | Itagaki, A. Sakurada, K. Matsuhama, M. Yajima, J. Yamashita, T. Kohzuki, M. | J Cardiol | 2020 |
Cardiac surgery |
| Preoperative Risk Assessment for Delirium After Hepatic Resection in the Elderly: a Prospective Multicenter Study | Ishihara, A. Tanaka, S. Ueno, M. Iida, H. Kaibori, M. Nomi, T. Hirokawa, F. Ikoma, H. Nakai, T. Eguchi, H. Shinkawa, H. Hayami, S. Maehira, H. Shibata, T. Kubo, S. | J Gastrointest Surg | 2020 |
Frailty |
| Emergence Delirium in Elderly Patients as a Potential Predictor of Subsequent Postoperative Delirium: A Descriptive Correlational Study | Huang, J. Qi, H. Lv, K. Chen, X. Zhuang, Y. Yang, L. | J Perianesth Nurs | 2020 |
correlation |
| Does Alzheimer's Disease and Related Dementias Modify Delirium Severity and Hospital Outcomes? | Hshieh, T. T. Fong, T. G. Schmitt, E. M. Marcantonio, E. R. Xu, G. Gou, Y. R. Travison, T. G. Metzger, E. D. Jones, R. N. Inouye, S. K. | J Am Geriatr Soc | 2020 |
Alzheimer’s disease and related dementias |
| A Multicomponent Nonpharmacological Intervention to Prevent Delirium for Hospitalized People with Advanced Cancer: A Phase II Cluster Randomized Waitlist Controlled Trial (The PRESERVE Pilot Study) | Hosie, A. Phillips, J. Lam, L. Kochovska, S. Noble, B. Brassil, M. Kurrle, S. Cumming, A. Caplan, G. A. Chye, R. Ely, E. W. Lawlor, P. G. Bush, S. H. Davis, J. M. Lovell, M. Parr, C. Williams, S. Hauser, K. McArdle, S. Jacquier, K. Phillipson, C. Kuwahata | J Palliat Med | 2020 |
cancer |