NIDUS Delirium Bibliography

Delirium Bibliography books graphic What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

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Title: Peripheral interleukin-6-associated microglial QUIN elevation in basolateral amygdala contributed to cognitive dysfunction in a mouse model of postoperative delirium

Authors: Mu, J. L. Liu, X. D. Dong, Y. H. Fang, Y. Y. Qiu, S. D. Zhang, F. Liu, K. X.

Year: 2022

Journal: Front Med (Lausanne)

Abstract: BACKGROUND: Developing effective approaches for postoperative delirium has been hampered due to the lack of a pathophysiologically similar animal model to offer insights into the pathogenesis. The study, therefore, aimed to develop a delirium-like mouse model and explore the underlying mechanism. METHODS: The three cycles of 10-min clamp following 5-min reopening of the superior mesenteric artery (SMA) were performed in adult male C57BL/6 mice to induce a delirium-like phenotype. Composite Z score calculated based on the results of Open Field, Y Maze and Buried Food Tests was employed to assess the delirium phenotype in mice. Microglia activities were monitored by immunofluorescence staining and comprehensive morphological analysis. Systemic administration of minocycline (MINO), IL-6 antibody or IL-6 neutralizing antibody, was applied to manipulate microglia. The expressions of Indoleamine 2,3-dioxygenase-1 (IDO-1) and quinolinic acid (QUIN) were examined by RT-PCR and High-Performance Liquid Chromatography/Mass Spectrometry, respectively. Cytokines were measured using fluorescence activated cell sorting method. RESULTS: The repeated ischemia/reperfusion (I/R) surgery caused significant anxiety (P < 0.05) and cognition decline in working memory and orientation (P < 0.05) in mice at postoperative 24 h. The composite Z score, indicating an overall disturbance of brain function, fluctuated over 24 h after I/R surgery (P < 0.001). Immunofluorescent staining showed that the percentage of microglia in the basolateral amygdala (BLA) (P < 0.05) was reactivated after I/R surgery and was negatively correlated with dwell time at Y maze (R = -0.759, P = 0.035). Inhibiting microglia activities by MINO reduced QUIN productions (P < 0.01) that improved cognitive deficits (P < 0.05). The peripheral IL-6 might cause IL-6 elevation in the BLA. Systemic administration of IL-6 antibodies suppressed I/R-induced IL-6 elevations (P < 0.05), microglial reactivations (P < 0.05), IDO-1 expressions (P < 0.01), and neuroactive metabolite QUIN productions (P < 0.05) in the BLA, resulting in a recovery of cognitive deficits (P < 0.05). Injection of IL-6 exerted opposite effects. CONCLUSION: The repeated intestinal I/R surgery-induced mouse model is a simple and reproducible one of postoperative delirium. Peripheral IL-6-associated microglial QUIN elevations in the BLA contributed to cognitive dysfunction in the model of postoperative delirium.

PMID: 36160165

Keywords: Bla
Il-6
Quin
delirium
microglia
repeated intestinal I/R

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Total Records Found: 6272, showing 100 per page
Title	Authors	Journal	Year	Keywords
Intraoperative hypotension and delirium in patients with hip fracture	Tantardini, V. Roca, F. Bahri, O. Compere, V. Dujardin, F. Chassagne, P.	Geriatr Psychol Neuropsychiatr Vieil	2020	anaesthesia delirium hip fracture low blood pressure
Evaluation of emergence agitation after general anaesthesia in rhinoplasty patients: Inhalation anaesthesia versus total intravenous anaesthesia	Talih, G. Yüksek, A. Şahin, E.	American Journal of Otolaryngology - Head and Neck Medicine and Surgery	2020	adult anesthesia induction article bleeding controlled study emergence agitation female gas flow human image quality incidence intravenous anesthesia Likert scale low flow anesthesia lung alveolus major clinical study male nausea and vomiting nose reconstruction prospective study randomized controlled trial Richmond Agitation Sedation Scale satisfaction surgeon propofol sevoflurane
Implementation of a multiprofessional, multicomponent delirium management guideline in two intensive care units, and its effect on patient outcomes and nurse workload: a pre-post design retrospective cohort study	Schubert, M. Bettex, D. Steiger, P. Schurch, R. Haller, A. Bogdanovic, J. Garcia Nunez, D. Schwarz, U. Siegemund, M.	Swiss Med Wkly	2020
Cerebrospinal Fluid Levels of Interleukin-8 in Delirium, Dementia, and Cognitively Healthy Patients	Sajjad, M. U. Blennow, K. Knapskog, A. B. Idland, A. V. Chaudhry, F. A. Wyller, T. B. Zetterberg, H. Watne, L. O.	J Alzheimers Dis	2020	Alzheimer’s disease cytokines delirium depression
Prehospital Anticholinergic Burden Is Associated With Delirium but Not With Mortality in a Population of Acutely Ill Medical Patients	Rigor, J. Rueff Rato, I. Ferreira, P. M. Pereira, R. Ribeiro, C. Teixeira, D. Mesquita Oliveira, P. Silva, A. M. Pereira, S. Costa, I. Ferreira, P. Sequeira, M. Monteiro-Soares, M. Martins-Mendes, D.	J Am Med Dir Assoc	2020	Anticholinergic delirium geriatrics mortality
Impact of Vitamin C and Thiamine Administration on Delirium-Free Days in Patients with Septic Shock	Park, J. E. Shin, T. G. Jo, I. J. Jeon, K. Suh, G. Y. Park, M. Won, H. Chung, C. R. Hwang, S. Y.	J Clin Med	2020	delirium sepsis septic shock thiamine vitamin C
Evaluation of an updated sedation protocol to reduce benzodiazepines in a pediatric intensive care unit	Michel, J. Hofbeck, M. Peper, A. K. Kumpf, M. Neunhoeffer, F.	Curr Med Res Opin	2020	Cardiac surgery analgesia congenital heart disease nurse-driven protocol pediatric delirium withdrawal
A qualitative exploration of the views of patients and their relatives regarding interventions to minimize the distress related to postoperative delirium	Meilak, C. Biswell, E. Willis, R. Partridge, J. Dhesi, J.	Int J Geriatr Psychiatry	2020	aged article clinical article communication skill family stress female human information seeking male patient counseling patient education postoperative delirium qualitative research relative semi structured interview staff training thematic analysis very elderly
Incidence and risk factors of postoperative delirium in elderly patients undergoing urological surgery: A multi-institutional prospective study	Matsuki, M. Tanaka, T. Takahashi, A. Inoue, R. Hotta, H. Itoh, N. Taguchi, K. Kato, R. Kobayashi, K. Masumori, N.	Int J Urol	2020	elderly patients multicenter prospective cohort study postoperative delirium risk factors urological surgery
Still Predicting Delirium After All These Years	Marcantonio, ER	Anesth Analg	2020
Ketamine sedation in mechanically ventilated patients: A systematic review and meta-analysis	Manasco, A. T. Stephens, R. J. Yaeger, L. H. Roberts, B. W. Fuller, B. M.	Journal of Critical Care	2020	fentanyl hypertensive factor ketamine midazolam propofol agitation article artificial ventilation delirium drug infusion human hypertension length of stay meta analysis mortality randomized controlled trial (topic) risk benefit analysis side effect systematic review tachycardia
A Study of the Psychometric Properties of the “Stanford Proxy Test for Delirium” (S-PTD): A New Screening Tool for the Detection of Delirium	Maldonado, J. R. Sher, Y. I. Benitez-Lopez, M. A. Savant, V. Garcia, R. Ament, A. De Guzman, E.	Psychosomatics	2020	adult article controlled study delirium demography diagnosis diagnostic test accuracy study early diagnosis female hospitalization human major clinical study male middle aged nurse psychiatrist sensitivity and specificity
Risk factors for postoperative delirium after colorectal surgery: a systematic review and meta-analysis	Lee, S. H. Lim, S. W.	Int J Colorectal Dis	2020	Colorectal surgery Postoperative delirium Risk factor
Results from a double blinded, randomized, placebo-controlled, feasibility trial of melatonin for the treatment of delirium in older medical inpatients	Lange, P. W. Clayton-Chubb, D. I. Watson, R. Maier, A. B.	Intern Med J	2020	Delirium Melatonin Neurocognitive Disorders Post-Operative Cognitive Decline Sepsis-Associated Encephalopathy Sleep Treatment
Risk factors and outcomes among delirium subtypes in adult ICUs: A systematic review	Krewulak, K. D. Stelfox, H. T. Ely, E. W. Fiest, K. M.	J Crit Care	2020	Critical care Delirium Risk factors Subtype Systematic review any conflicts of interest relevant to this manuscript.
Survey of analgesia and sedation in pediatric intensive care units in Japan	Koizumi, T. Kurosawa, H.	Pediatr Int	2020	analgesia delirium pediatric intensive care units sedation withdrawal syndrome
Association of neuronal repair biomarkers with delirium among survivors of critical illness	Hayhurst, C. J. Patel, M. B. McNeil, J. B. Girard, T. D. Brummel, N. E. Thompson, J. L. Chandrasekhar, R. Ware, L. B. Pandharipande, P. P. Ely, E. W. Hughes, C. G.	Journal of Critical Care	2020	NCT00392795 brain derived neurotrophic factor interleukin 6 ubiquitin carboxyl terminal esterase L1 ubiquitin thiolesterase unclassified drug adult aged APACHE article Charlson Comorbidity Index clinical trial cohort analysis controlled study critically ill patient delirium disease duration female hospital admission human intensive care unit major clinical study male observational study pathophysiology population research prevalence prospective study protein blood level respiratory failure shock survivor
Dexmedetomidine's Relationship to Delirium in Patients Undergoing Cardiac Surgery: A Systematic Review	Halpin, E. Inch, H. O'Neill, M.	Crit Care Nurs Q	2020
Management of delirium at an academic medical center: Plans for antipsychotic prescribing upon discharge	Halavonich, L. Robert, S. McGraw, D. Weeda, E. Mullinax, K. Bass, B.	Ment Health Clin	2020	antipsychotic delirium discharge disclose.
Association Between Level of Arousal and 30-Day Survival in Acutely Ill Older Adults	Garcez, F. B. Jacob-Filho, W. Avelino-Silva, T. J.	J Am Med Dir Assoc	2020	Delirium arousal dementia hospitalization mortality
Drug therapy for delirium in terminally ill adults	Finucane, A. M. Jones, L. Leurent, B. Sampson, E. L. Stone, P. Tookman, A. Candy, B.	Cochrane Database Syst Rev	2020
Delirium in patients with hip fracture is associated with increased heart rate variability	Ernst, G. Watne, L. O. Rostrup, M. Neerland, B. E.	Aging Clin Exp Res	2020	Autonomic nervous system Delirium Heart rate variability Hip fracture
Risk factors for delirium after esophagectomy	Dezube, A. R. Bravo-Iniguez, C. E. Yelamanchili, N. De Leon, L. E. Tarascio, J. Jaklitsch, M. T. Wee, J. O.	J Surg Oncol	2020	delirium esophageal cancer esophagectomy perioperative factors surgical outcomes surgical technique
Delirium in a Tertiary PICU: Risk Factors and Outcomes	Dervan, L. A. Di Gennaro, J. L. Farris, R. W. D. Watson, R. S.	Pediatr Crit Care Med	2020
Validity and Reliability of the Brazilian Portuguese Version of the Pediatric Confusion Assessment Method for the ICU	de Castro, R. E. V. Prata-Barbosa, A. de Magalhaes-Barbosa, M. C. Cunha, Ajlad Cheniaux, E. Smith, H. A. B.	Pediatr Crit Care Med	2020
Outcomes for patients with delirium receiving hospital-in-the-home treatment: An Australian perspective	Chia, J. Eeles, E. M. Tattam, K. Yerkovich, S.	Australas J Ageing	2020	delirium frail elderly home care services hospital-based
A software to prevent delirium in hospitalised older adults: development and feasibility assessment	Alvarez, E. A. Garrido, M. Ponce, D. P. Pizarro, G. Cordova, A. A. Vera, F. Ruiz, R. Fernandez, R. Velasquez, J. D. Tobar, E. Salech, F.	Age Ageing	2020	delirium gerontechnology non-pharmacological interventions prevention software
Cholinesterase alterations in delirium after cardiosurgery: a German monocentric prospective study	Adam, E. H. Haas, V. Lindau, S. Zacharowski, K. Scheller, B.	BMJ Open	2020	acetylcholinesterase butyrylcholinesterase cardiac surgery cholinesterase postoperative delirium
Cornell Assessment of Pediatric Delirium: a valid, rapid, observational tool for screening delirium in the PICU*	Traube, C. Silver, G. Kearney, J. Patel, A. Atkinson, T. M. Yoon, M. J. Halpert, S. Augenstein, J. Sickles, L. E. Li, C. Greenwald, B.	Crit Care Med	2014	Adolescent Age Distribution Child Child, Preschool Cohort Studies Critical Care/methods Delirium/diagnosis/epidemiology Diagnostic and Statistical Manual of Mental Disorders Feasibility Studies Female Humans Infant Infant, Newborn Intensive Care Units, Pediatric Male Mass Screening/*methods Prevalence Psychometrics Reproducibility of Results Sensitivity and Specificity Severity of Illness Index Sex Distribution Young Adult
The Preschool Confusion Assessment Method for the ICU: Valid and Reliable Delirium Monitoring for Critically Ill Infants and Children	Smith, H. A. Gangopadhyay, M. Goben, C. M. Jacobowski, N. L. Chestnut, M. H. Savage, S. Rutherford, M. T. Denton, D. Thompson, J. L. Chandrasekhar, R. Acton, M. Newman, J. Noori, H. P. Terrell, M. K. Williams, S. R. Griffith, K. Cooper, T. J. Ely, E. W. F	Crit Care Med	2016	Child, Preschool Confusion/diagnosis Critical Illness Delirium/diagnosis Female Humans Infant Intensive Care Units, Pediatric Male *Neuropsychological Tests Observer Variation Prospective Studies Reproducibility of Results Respiration, Artificial Sensitivity and Specificity Severity of Illness Index
Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit	Smith, H. A. Boyd, J. Fuchs, D. C. Melvin, K. Berry, P. Shintani, A. Eden, S. K. Terrell, M. K. Boswell, T. Wolfram, K. Sopfe, J. Barr, F. E. Pandharipande, P. P. Ely, E. W.	Crit Care Med	2011	Child Child, Preschool Cohort Studies Confusion/diagnosis Critical Care/methods Critical Illness Delirium/diagnosis Female Humans *Intensive Care Units, Pediatric Male Neuropsychiatry/standards Observer Variation Practice Guidelines as Topic Prospective Studies Psychometrics Reference Standards Reproducibility of Results Risk Assessment Sensitivity and Specificity Severity of Illness Index
Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale	Sikich, N. Lerman, J.	Anesthesiology	2004	Anesthesia Recovery Period Child Confidence Intervals Delirium/diagnosis/psychology Humans Postoperative Complications/diagnosis/*psychology Psychometrics
From Pediatrics to Geriatrics: Toward a Unified Standardized Screening Tool for Delirium: A Thought Experiment	Schieveld, J. N. van Zwieten, J. J.	Crit Care Med	2016	Adult Age Factors Aged Child Delirium/*diagnosis Humans Mass Screening
Diagnostic considerations regarding pediatric delirium: a review and a proposal for an algorithm for pediatric intensive care units	Schieveld, J. N. van der Valk, J. A. Smeets, I. Berghmans, E. Wassenberg, R. Leroy, P. L. Vos, G. D. van Os, J.	Intensive Care Med	2009	Age Factors Algorithms Child Child, Preschool Consciousness Disorders/diagnosis/etiology Critical Care/methods Decision Trees Delirium/*diagnosis/epidemiology/etiology/therapy Diagnosis, Differential Diagnostic and Statistical Manual of Mental Disorders Early Diagnosis Humans Intensive Care Units, Pediatric Pain Measurement Pediatrics/methods Psychiatric Status Rating Scales Psychometrics Risk Assessment/methods Risk Factors Severity of Illness Index Vital Signs
On the utility of diagnostic instruments for pediatric delirium in critical illness: an evaluation of the Pediatric Anesthesia Emergence Delirium Scale, the Delirium Rating Scale 88, and the Delirium Rating Scale-Revised R-98	Janssen, N. J. Tan, E. Y. Staal, M. Janssen, E. P. Leroy, P. L. Lousberg, R. van Os, J. Schieveld, J. N.	Intensive Care Med	2011	Anesthesia Recovery Period Child Critical Illness Delirium/*diagnosis Female Humans Intensive Care Units, Pediatric Male Prospective Studies Psychiatric Status Rating Scales Reproducibility of Results Risk Assessment Severity of Illness Index
Validation of the SOS-PD scale for assessment of pediatric delirium: a multicenter study	Ista, E. van Beusekom, B. van Rosmalen, J. Kneyber, M. C. J. Lemson, J. Brouwers, A. Dieleman, G. C. Dierckx, B. de Hoog, M. Tibboel, D. van Dijk, M.	Crit Care	2018	Adolescent Child Child, Preschool Delirium/classification/diagnosis/mortality Female Humans Infant Male Netherlands Pediatrics/methods/statistics & numerical data Prospective Studies Psychometrics/instrumentation/methods/standards Reproducibility of Results Research Design/standards/statistics & numerical data Assessment tool Benzodiazepine Iatrogenic withdrawal syndrome (IWS) Picu Pediatric delirium Sedation
Sophia Observation withdrawal Symptoms-Paediatric Delirium scale: A tool for early screening of delirium in the PICU	Ista, E. Te Beest, H. van Rosmalen, J. de Hoog, M. Tibboel, D. van Beusekom, B. van Dijk, M.	Aust Crit Care	2018	Adolescent Child Child, Preschool Critical Illness Delirium/diagnosis Humans Infant Intensive Care Units, Pediatric Male Mass Screening/methods Prospective Studies Reproducibility of Results Sensitivity and Specificity Assessment tool Benzodiazepine Iatrogenic withdrawal syndrome (IWS) Picu Paediatric Delirium Sedation
Psychometric evaluation of the Sophia Observation withdrawal symptoms scale in critically ill children	Ista, E. de Hoog, M. Tibboel, D. Duivenvoorden, H. J. van Dijk, M.	Pediatr Crit Care Med	2013	Adolescent Analgesics, Opioid/adverse effects Benzodiazepines/adverse effects Child Child, Preschool Critical Illness Female Hospitals, University Humans Infant Infant, Newborn Intensive Care Units, Pediatric Male Prospective Studies Psychometrics Risk Factors Sensitivity and Specificity Severity of Illness Index Substance Withdrawal Syndrome/diagnosis/psychology
Clinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals	Harris, J. Ramelet, A. S. van Dijk, M. Pokorna, P. Wielenga, J. Tume, L. Tibboel, D. Ista, E.	Intensive Care Med	2016	Child Child, Preschool Consensus Critical Illness Delirium/diagnosis/therapy Emergence Delirium/diagnosis/therapy Humans Hypnotics and Sedatives/therapeutic use Infant Infant, Newborn Intensive Care Units/standards Pain Management/methods Pain Measurement/methods Practice Guidelines as Topic Psychomotor Agitation/diagnosis/drug therapy Stress, Psychological Substance Withdrawal Syndrome/diagnosis/therapy Assessment Delirium Distress Pain Sedation Withdrawal syndrome
Assessment scales for delirium: A review	Grover, S. Kate, N.	World J Psychiatry	2012	Cognition Delirium Diagnosis Screening
Diagnostic accuracy of delirium diagnosis in pediatric intensive care: a systematic review	Daoud, A. Duff, J. P. Joffe, A. R. Alberta Sepsis, Network	Crit Care	2014	Anesthesia/adverse effects Child Delirium/diagnosis/etiology/psychology Humans Intensive Care Units, Pediatric/standards Psychiatric Status Rating Scales/standards
Diagnostic accuracy of delirium diagnosis in pediatric intensive care: a systematic review	Daoud, A. Duff, J. P. Joffe, A. R. Alberta Sepsis, Network	Crit Care	2014	Anesthesia/adverse effects Child Delirium/diagnosis/etiology/psychology Humans Intensive Care Units, Pediatric/standards Psychiatric Status Rating Scales/standards
Delirium is prevalent in older hospital inpatients and associated with adverse outcomes: Results of a prospective multi-centre study on World Delirium Awareness Day	Welch, C. McCluskey, L. Wilson, D. Chapman, G. E. Jackson, T. A. Treml, J. Davis, D. Cunningham, E. Copeland, C. Quinn, T. Pinkney, T. Mahida, R. Nightingale, P. Richardson, S. Todd, O. Willott, R. Torsney, K. Ni Lochlainn, M. Giridharan, K. Cox, N. Masol	BMC Medicine	2019	adult adverse outcome aged article awareness clinical practice delirium female frailty hospital admission hospital patient human length of stay major clinical study male mortality rate observational study prospective study United Kingdom
Olanzapine Versus Haloperidol for Treatment of Delirium in Patients with Advanced Cancer: A Phase III Randomized Clinical Trial	van der Vorst, Mjdl Neefjes, E. C. W. Boddaert, M. S. A. Verdegaal, Batt Beeker, A. Teunissen, S. C. C. Beekman, A. T. F. Wilschut, J. A. Berkhof, J. Zuurmond, W. W. A. Verheul, H. M. W.	Oncologist	2019	Advanced cancer Delirium Efficacy Haloperidol Olanzapine Phase III Safety article.
Diverging Awareness of Postoperative Delirium and Cognitive Dysfunction in German Health Care Providers	Sturm, H. Wildermuth, R. Stolz, R. Bertram, L. Eschweiler, G. W. Thomas, C. Rapp, M. Joos, S.	Clin Interv Aging	2019	Pocd clinical pathways cross-sectoral care delirium prevention dementia postoperative cognitive dysfunction risk screening
An evaluation of the Danish version of the Pediatric Anesthesia Emergence Delirium scale	Simonsen, B. Y. Skovby, P. Lisby, M.	Acta Anaesthesiol Scand	2019
Incidence and Risk Factors for Delirium in Elderly Patients with Critical Limb Ischaemia	Roijers, J. P. Rakke, Y. S. Hopmans, C. J. Buimer, M. G. de Groot, H. G. W. Ho, G. H. Veen, E. J. Mulder, P. G. H. van der Laan, L.	Eur J Vasc Endovasc Surg	2019	Critical limb ischaemia Delirium Risk factors
Initiative for Prevention and Early Identification of Delirium in Medical-Surgical Units: Lessons Learned in the Past Five Years	Rohatgi, N. Weng, Y. Bentley, J. Lansberg, M. G. Shepard, J. Mazur, D. Ahuja, N. Hopkins, J.	Am J Med	2019	Delirium Medical-surgical units Prevention Quality improvement
Elevation of Preoperative Ammonia Level Is Not Associated With the Incidence of Postoperative Delirium in Patients with Liver Transplantation: A Propensity Score Matching Analysis	Ri, H. S. Choi, Y. J. Park, J. Y. Jin, S. J. Lee, Y. S. Son, J. M. Yoon, S. Z. Shin, H. W. Choi, B. H. Lee, T. B.	Transplant Proc	2019
Fluctuations of consciousness after stroke: Associations with the confusion assessment method for the intensive care unit (CAM-ICU) and potential undetected delirium	Reznik, M. E. Daiello, L. A. Thompson, B. B. Wendell, L. C. Mahta, A. Potter, N. S. Yaghi, S. Levy, M. M. Fehnel, C. R. Furie, K. L. Jones, R. N.	J Crit Care	2019	Consciousness Delirium Sepsis Stroke
Postoperative serum albumin decrease independently predicts delirium in elderly subjects after total joint arthroplasty	Qi, J. Liu, C. Chen, L. Chen, J.	Curr Pharm Des	2019	Postoperative delirium albumin elderly risk factor total joint arthroplasty
Dexmedetomidine versus propofol sedation in reducing delirium among older adults in the ICU: A systematic review and meta-analysis	Pereira, J. V. Sanjanwala, R. M. Mohammed, M. K. Le, M. L. Arora, R. C.	Eur J Anaesthesiol	2019
Delirium Rates in Advanced Cancer Patients Admitted to Different Palliative Care Settings: Does It Make the Difference?	Pallotti, M. C. Lopez-Fidalgo Ph, D. J. Biasco, G. Celin, D. Centeno, C. Paragona, M. Moroni, M. Noguera, A.	J Palliat Med	2019	cancer patients course delirium precipitants rates
Randomized Controlled Trial of Enhanced Recovery Program Dedicated to Elderly Patients after Colorectal Surgery	Ostermann, S. Morel, P. Chalé, J. J. Bucher, P. Konrad, B. Meier, R. P. H. Ris, F. Schiffer, E. R. C.	Diseases of the Colon and Rectum	2019	NCT01646190 nasogastric tube amiodarone antibiotic agent anticoagulant agent creatinine opiate adult respiratory distress syndrome advanced cancer aged anus fissure article atrial fibrillation bladder catheterization bleeding blood transfusion body mass cardiopulmonary arrest Charlson Comorbidity Index clinical pathway colorectal surgery constipation controlled study creatinine blood level defecation delirium disseminated intravascular clotting dyspnea elective surgery enhanced recovery after surgery female functional status gastrointestinal hemorrhage geriatrics heart failure heart infarction hematoma high volume hospital hospital readmission human hypovolemic shock ileus incisional hernia infectious complication intestine function intestine obstruction intubation kidney failure larynx edema length of stay lung insufficiency major clinical study male mortality rate multiple organ failure nutritional status open surgery operation duration outcome assessment perioperative period pleura effusion pneumonia postoperative complication postoperative ileus postoperative pain practice guideline preoperative radiotherapy protocol compliance pyelonephritis randomized controlled trial reoperation small intestine obstruction surgical infection surgical stress surgical technique survival prediction thrombocytopenia total parenteral nutrition university hospital urinary tract infection urine retention
The effect of ketamine on emergence agitation in children: A systematic review and meta-analysis	Ng, K. T. Sarode, D. Lai, Y. S. Teoh, W. Y. Wang, C. Y.	Paediatr Anaesth	2019	emergence agitation emergence delirium ketamine meta-analysis pain systematic review
BIS index monitoring and perioperative neurocognitive disorders in older adults: a systematic review and meta-analysis	Miao, M. Xu, Y. Sun, M. Chang, E. Cong, X. Zhang, J.	Aging Clin Exp Res	2019	Bispectral index Meta-analysis Older adults Perioperative neurocognitive disorders Postoperative delirium
Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients	McNeil, J. B. Hughes, C. G. Girard, T. Ware, L. B. Ely, E. W. Chandrasekhar, R. Han, J. H.	PLoS One	2019
Randomized controlled trial of acupuncture to prevent emergence delirium in children undergoing myringotomy tube placement	Martin, C. S. Yanez, N. D. Treggiari, M. M. Piper, L. Cusick, J. Lalwani, K.	Minerva Anestesiol	2019
Detecting delirium in patients with acute stroke: a systematic review of test accuracy	Mansutti, I. Saiani, L. Palese, A.	BMC Neurol	2019	Instruments Intracerebral Haemorrhage Ischaemic stroke Post-stroke delirium Sensitivity Specificity Systematic review Tools
Associations of 4AT with mobility, length of stay and mortality in hospital and discharge destination among patients admitted with hip fractures	Lisk, R. Yeong, K. Enwere, P. Jenkinson, J. Robin, J. Irvin-Sellers, M. Fluck, D. Osmani, A. Sharmin, R. Sharma, P. Fry, C. H. Han, T. S.	Age Ageing	2019	Nhs cognitive function geriatrics health economics older people
Effectiveness of an advanced practice nurse-led delirium education and training programme	Lieow, J. L. M. Chen, F. S. M. Song, G. Tang, P. S. Kowitlawakul, Y. Mukhopadhyay, A.	Int Nurs Rev	2019	Advanced Practice Nurses Critical Care Delirium Screening Education Intensive Care Unit Nursing
Comparison of emergence agitation between succinylcholine and rocuronium-sugammadex in adults following closed reduction of a nasal bone fracture: A prospective randomized controlled trial	Lee, S. J. Sung, T. Y. Cho, C. K.	BMC Anesthesiology	2019	adult article case report clinical article closed reduction (procedure) drug therapy effect size emergence agitation female general anesthesia human incidence male neuromuscular blocking nose fracture outcome assessment prospective study randomized controlled trial risk factor rocuronium sodium chloride sugammadex suxamethonium
Risk factors for post-intensive care syndrome: A systematic review and meta-analysis	Lee, M. Kang, J. Jeong, Y. J.	Aust Crit Care	2019	Intensive care units Meta-analysis Post-intensive care syndrome Risk factors Survivors
Effect of Perioperative Low-Dose Dexmedetomidine on Postoperative Delirium After Living-Donor Liver Transplantation: A Randomized Controlled Trial	Lee, H. Yang, S. M. Chung, J. Oh, H. W. Yi, N. J. Suh, K. S. Oh, S. Y. Ryu, H. G.	Transplant Proc	2019
The Association of Perioperative Serum Lactate Levels with Postoperative Delirium in Elderly Trauma Patients	Lee, C. Lee, J. Cho, H. Song, J. Jung, H. Ma, X. Hwang, J.	BioMed Research International	2019	lactic acid aged article cohort analysis controlled study disease association female hospital admission human injury intensive care unit lactate blood level major clinical study male perioperative period postoperative delirium retrospective study
Frailty defined by 19 items as a predictor of short-term functional recovery in patients with hip fracture	Inoue, T. Misu, S. Tanaka, T. Kakehi, T. Kakiuchi, M. Chuman, Y. Ono, R.	Injury	2019	aged article atrial fibrillation clinical outcome cohort analysis convalescence deep vein thrombosis delirium female frailty Functional Independence Measure functional status assessment hip fracture hospital discharge human major clinical study male Modified Frailty Index multicenter study observational study pneumonia postoperative complication priority journal retrospective study urinary tract infection very elderly
Using language descriptors to recognise delirium: a survey of clinicians and medical coders to identify delirium-suggestive words	Holmes, N. E. Amjad, S. Young, M. Berlowitz, D. J. Bellomo, R.	Crit Care Resusc	2019	Clinical Coding Critical Care/standards Cross-Sectional Studies Delirium/diagnosis Health Knowledge, Attitudes, Practice Humans Intensive Care Units Language Medical Staff/statistics & numerical data Physicians/statistics & numerical data *Surveys and Questionnaires
Diagnostic test accuracy meta-analysis of PRE-DELIRIC (PREdiction of DELIRium in ICu patients): A delirium prediction model in intensive care practice	Ho, M. H. Chen, K. H. Montayre, J. Liu, M. F. Chang, C. C. Traynor, V. Shen Hsiao, S. T. Chang, H. R. Chiu, H. Y.	Intensive Crit Care Nurs	2019	Delirium Diagnostic test Meta-analysis Pre-deliric Sensitivity and specificity
Delirium management: Let's get physical? A systematic review and meta-analysis	Haley, M. N. Casey, P. Kane, R. Y. Darzins, P. Lawler, K.	Australas J Ageing	2019	delirium exercise physical activity physical mobility physical therapy
Delirium post-cardiac surgery: Incidence and associated factors	Habeeb-Allah, A. Alshraideh, J. A.	Nurs Crit Care	2019	associated factors cardiac surgery delirium incidence post-operative delirium
EEG Correlates of Delirium in Children and Young Adults With CD19-Directed CAR T Cell Treatment-Related Neurotoxicity	Gust, J. Annesley, C. E. Gardner, R. A. Bozarth, X.	J Clin Neurophysiol	2019
Process of implementing and delivering the Prevention of Delirium system of care: a mixed method preliminary study	Godfrey, M. Green, J. Smith, J. Cheater, F. Inouye, S. K. Hurst, K. Young, J.	BMC Geriatr	2019	Delirium prevention Hospital care Hospital volunteers Implementation Older people
Association between postoperative delirium and postoperative cerebral oxygen desaturation in older patients after cardiac surgery	Eertmans, W. De Deyne, C. Genbrugge, C. Marcus, B. Bouneb, S. Beran, M. Fret, T. Gutermann, H. Boer, W. Vander Laenen, M. Heylen, R. Mesotten, D. Vanelderen, P. Jans, F.	Br J Anaesth	2019	cardiac surgery cerebral oxygen saturation delirium intensive care unit near-infrared spectroscopy neurological outcome postoperative delirium
Frailty and hospital outcomes within a low socioeconomic population	Clark, S. Shaw, C. Padayachee, A. Howard, S. Hay, K. Frakking, T. T.	QJM	2019
Perioperative outcomes in geriatric patients undergoing hip fracture surgery with different anesthesia techniques: A systematic review and meta-analysis	Chen, D. X. Yang, L. Ding, L. Li, S. Y. Qi, Y. N. Li, Q.	Medicine	2019	Aged Aged, 80 and over Anesthesia/methods/mortality Hip Fractures/mortality/surgery Hospital Mortality Humans Postoperative Complications/mortality
Postoperative delirium is associated with increased plasma neurofilament light	Casey, C. P. Lindroth, H. Mohanty, R. Farahbakhsh, Z. Ballweg, T. Twadell, S. Miller, S. Krause, B. Prabhakaran, V. Blennow, K. Zetterberg, H. Sanders, R. D.	Brain	2019	adult article cognitive defect cohort analysis controlled study dose response female fractional anisotropy hippocampus human human tissue incidence inflammation major clinical study male nerve degeneration nerve injury neurofilament neurotoxicity nuclear magnetic resonance imaging postoperative delirium preoperative evaluation prospective study protein expression radial diffusivity surgical patient white matter biological marker endogenous compound interleukin 8
Differential clinical characteristics, management and outcome of delirium among ward compared with intensive care unit patients	Canet, E. Amjad, S. Robbins, R. Lewis, J. Matalanis, M. Jones, D. Bellomo, R.	Intern Med J	2019	agitation anti-psychotics delirium intensive care unit *ward
An Evaluation of Risperidone Dosing for Pediatric Delirium in Children Less Than or Equal to 2 Years of Age	Campbell, C. T. Grey, E. Munoz-Pareja, J. Manasco, K. B.	Annals of Pharmacotherapy	2019	article child clinical article controlled study delirium drug megadose drug therapy drug withdrawal female human institutional review male outcome assessment pediatric intensive care unit psychosis retrospective study sedation treatment duration university hospital fentanyl ketamine midazolam morphine risperidone
Inpatient Rehabilitation Delirium Screening: Impact on Acute Care Transfers and Functional Outcomes	Bushi, S. Barrett, A. M. Oh-Park, M.	PMR	2019	Acute Care Transfer Delirium Rehabilitation
Routine Management of Postoperative Delirium Outside the ICU: Results of an International Survey among Anaesthesiologists	Bilotta, F. Weiss, B. Neuner, B. Kramer, S. Aldecoa, C. Bettelli, G. Sanders, R. D. Delp, S. M. Spies, C. D.	Acta Anaesthesiol Scand	2019	Postoperative delirium anaesthesiologists practice survey
Impact of delirium on short-term outcomes in hip fracture patients under a program of approach to delirium	Bielza, R. Zambrana, F. Fernandez de la Puente, E. Sanjurjo, J. Andreu, C. Thuissard, I. J. Gomez Cerezo, J.	Geriatr Gerontol Int	2019	delirium dementia orthopedics
Outcome Differences by Delirium Motor Subtype in Patients with Ischemic Stroke	Yang, H. W. Lee, M. Shin, J. W. Jeong, H. S. Kim, J. Kim, J. L.	Psychiatry Investig	2019	Delirium Ischemic stroke Motor subtype Outcomes
Serial Ottawa 3DY assessments to detect delirium in older emergency department community dwellers	Yadav, K. Boucher, V. Carmichael, P. H. Voyer, P. Eagles, D. Pelletier, M. Gouin, E. Daoust, R. Vu, T. T. M. Berthelot, S. Emond, M.	Age Ageing	2019	delirium detection emergency department older people
Development and validation of a postoperative delirium prediction model for patients admitted to an intensive care unit in China: a prospective study	Xing, H. Zhou, W. Fan, Y. Wen, T. Wang, X. Chang, G.	BMJ Open	2019	delirium intensive care models, statistical postoperative
Acute kidney injury as a risk factor of hyperactive delirium: A case control study	Wan, R. McKenzie, C. A. Taylor, D. Camporota, L. Ostermann, M.	J Crit Care	2019	Acute kidney injury Critical care Delirium Intensive care
The Effect of Frailty on Outcome After Vascular Surgery	Visser, L. Banning, L. B. D. El Moumni, M. Zeebregts, C. J. Pol, R. A.	European Journal of Vascular and Endovascular Surgery	2019	adverse outcome aged article body mass Charlson Comorbidity Index clinical evaluation cognition cognitive defect cohort analysis comorbidity comparative study delirium elective surgery female fitness frail elderly frailty functional status functional status assessment Groningen Frailty Indicator health care facility hearing high risk patient hospital discharge hospital readmission human hypertension major clinical study male morbidity mortality rate nutrition observational study outcome assessment people by smoking status physical mobility priority journal prospective study psychosocial disorder sex sex ratio social psychology surgical patient vascular surgery vision
Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions	Vasunilashorn, S. M. Ngo, L. H. Inouye, S. K. Fong, T. G. Jones, R. N. Dillon, S. T. Libermann, T. A. O'Connor, M. Arnold, S. E. Xie, Z. Marcantonio, E. R.	Alzheimers Dement	2019	Apolipoprotein E C-reactive protein Delirium Gene-protein interaction Inflammation
In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium	Vahidy, F. S. Bambhroliya, A. B. Meeks, J. R. Rahman, O. Ely, E. W. Slooter, A. J. C. Tyson, J. E. Miller, C. C. McCullough, L. D. Savitz, S. I. Khan, B.	PLoS One	2019
Reducing delirium and cognitive dysfunction after off-pump coronary bypass: A randomized trial	Szwed, K. Pawliszak, W. Szwed, M. Tomaszewska, M. Anisimowicz, L. Borkowska, A.	Journal of Thoracic and Cardiovascular Surgery	2019	adult artery formation (physiology) article brain clinical outcome complication controlled study coronary artery disease embolism female flooding human incidence major clinical study male neurologic disease off pump coronary surgery post hoc analysis postoperative cognitive dysfunction postoperative delirium randomized controlled trial single blind procedure surgery vein graft carbon dioxide
A randomized control trial comparing prophylactic dexmedetomidine versus clonidine on rates and duration of delirium in older adult patients undergoing coronary artery bypass grafting	Shokri, H. Ali, I.	Journal of Clinical Anesthesia	2019	adult aged analgesia article artificial ventilation body weight bradycardia controlled study coronary artery bypass graft drug therapy extubation female hospital mortality hospitalization human incidence infusion rate inotropism intensive care unit major clinical study male mean arterial pressure morphine addiction mortality rate postoperative delirium prospective study randomized controlled trial sedation surgery university hospital clonidine dexmedetomidine haloperidol morphine
Predisposing and precipitating risk factors for delirium in palliative care patients	Seiler, A. Schubert, M. Hertler, C. Schettle, M. Blum, D. Guckenberger, M. Weller, M. Ernst, J. von Kanel, R. Boettger, S.	Palliat Support Care	2019	Delirium Palliative care patients Palliative treatment Precipitating factors Predisposing factors Risk factors
Preventive effect of dexmedetomidine on postictal delirium after electroconvulsive therapy: A randomised controlled study	Qiu, Z. Zhou, S. Zhang, M. Guo, N. Huang, P. Xiang, P. Hei, Z. Li, X.	Eur J Anaesthesiol	2019
Activity-based occupational therapy intervention for delirium superimposed on dementia in nursing home setting: a feasibility study	Pozzi, C. Lanzoni, A. Lucchi, E. Salimbeni, I. DeVreese, L. P. Bellelli, G. Fabbo, A. Morandi, A.	Aging Clin Exp Res	2019	Delirium Dementia Nursing home Occupational therapy Tailor-made activity
Trials Focusing on Prevention and Treatment of Delirium After Cardiac Surgery: A systematic Review of Randomized Evidence	Pieri, M. De Simone, A. Rose, S. De Domenico, P. Lembo, R. Denaro, G. Landoni, G. Monaco, F.	Journal of Cardiothoracic and Vascular Anesthesia	2019	adult anesthesia cardiopulmonary bypass controlled study double blind procedure Europe female heart surgery human intensive care ischemic preconditioning male Medline North America operating room postoperative delirium prevention randomized controlled trial (topic) review Scopus surgery systematic review dexmedetomidine glucocorticoid inhalation anesthetic agent ketamine local anesthetic agent neuroleptic agent opiate propofol
Association of comt val158met polymorphism with delirium risk and outcomes after traumatic brain injury	Nekrosius, D. Kaminskaite, M. Jokubka, R. Pranckeviciene, A. Lideikis, K. Tamasauskas, A. Bunevicius, A.	Journal of Neuropsychiatry and Clinical Neurosciences	2019	methionine valine adult age alcohol abuse allele article cognition cohort analysis COMT gene delirium female functional status gene genetic association genotype Glasgow coma scale Glasgow Outcome on Discharge Scale human injury severity major clinical study male Montreal cognitive assessment observational study patient monitoring patient risk priority journal prospective study rating scale risk factor single nucleotide polymorphism traumatic brain injury
Anticholinergic burden of long-term medication is an independent risk factor for the development of postoperative delirium: A clinical trial	Mueller, A. Spies, C. D. Eckardt, R. Weiss, B. Pohrt, A. Wernecke, K. D. Schmidt, M.	Journal of Clinical Anesthesia	2019	aged article cancer patient cancer surgery complication controlled study ethics female female genital tract cancer Germany human intervention study major clinical study male non invasive procedure outcome assessment polypharmacy postoperative delirium preoperative evaluation randomized controlled trial risk assessment risk factor university hospital cholinergic receptor blocking agent
Renal function and delirium in older fracture patients: different information from different formulas?	Mossello, E. Rivasi, G. Tortu, V. Giordano, A. Iacomelli, I. Cavallini, M. C. Rafanelli, M. Ceccofiglio, A. Cartei, A. Rostagno, C. Bari, M. D. Ungar, A.	Eur J Intern Med	2019	Creatinine Cystatin C Delirium Glomerular filtration rate
Reversibility of delirium in Ill-hospitalized cancer patients: Does underlying etiology matter?	Matsuda, Y. Maeda, I. Morita, T. Yamauchi, T. Sakashita, A. Watanabe, H. Kaneishi, K. Amano, K. Iwase, S. Ogawa, A. Yoshiuchi, K.	Cancer Med	2019	cancer cause delirium palliative care reversibility
Association Between Perioperative Hypotension and Delirium in Postoperative Critically Ill Patients: A Retrospective Cohort Analysis	Maheshwari, K. Ahuja, S. Khanna, A. K. Mao, G. Perez-Protto, S. Farag, E. Turan, A. Kurz, A. Sessler, D. I.	Anesth Analg	2019
A short delirium caregiver questionnaire for triage of elderly outpatients with cognitive impairment: a development and test accuracy study	Luijendijk, H. J. Quispel-Aggenbach, D. W. P. Stroomer-van Wijk, A. J. M. Meijerink-Blom, A. H. van Walbeek, A. Zuidema, S. U.	International Psychogeriatrics	2019	aged article caregiver cognitive defect controlled study diagnostic test accuracy study disease course emergency health service female gerontopsychiatry hallucination human major clinical study male outcome assessment outpatient patient referral questionnaire sensitivity and specificity sleep telephone