What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Pharmacological interventions for the treatment of delirium in critically ill adults
- Authors
- Burry, L. Hutton, B. Williamson, D. R. Mehta, S. Adhikari, N. K. Cheng, W. Ely, E. W. Egerod, I. Fergusson, D. A. Rose, L.
- Year
- 2019
- Journal
- Cochrane Database Syst Rev
- Abstract
BACKGROUND: Although delirium is typically an acute reversible cognitive impairment, its presence is associated with devastating impact on both short-term and long-term outcomes for critically ill patients. Advances in our understanding of the negative impact of delirium on patient outcomes have prompted trials evaluating multiple pharmacological interventions. However, considerable uncertainty surrounds the relative benefits and safety of available pharmacological interventions for this population. OBJECTIVES: Primary objective1. To assess the effects of pharmacological interventions for treatment of delirium on duration of delirium in critically ill adults with confirmed or documented high risk of deliriumSecondary objectivesTo assess the following:1. effects of pharmacological interventions on delirium-free and coma-free days; days with coma; delirium relapse; duration of mechanical ventilation; intensive care unit (ICU) and hospital length of stay; mortality; and long-term outcomes (e.g. cognitive; discharge disposition; health-related quality of life); and2. the safety of such treatments for critically ill adult patients. SEARCH METHODS: We searched the following databases from their inception date to 21 March 2019: Ovid MEDLINE(R), Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Embase Classic+Embase, and PsycINFO using the Ovid platform. We also searched the Cochrane Library on Wiley, the International Prospective Register of Systematic Reviews (PROSPERO) (http://www.crd.york.ac.uk/PROSPERO/), the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. We performed a grey literature search of relevant databases and websites using the resources listed in Grey Matters developed by the Canadian Agency for Drugs and Technologies in Health (CADTH). We also searched trial registries and abstracts from annual scientific critical care and delirium society meetings. SELECTION CRITERIA: We sought randomized controlled trials (RCTs), including quasi-RCTs, of any pharmacological (drug) for treatment of delirium in critically ill adults. The drug intervention was to be compared to another active drug treatment, placebo, or a non-pharmacological intervention (e.g. mobilization). We did not apply any restrictions in terms of drug class, dose, route of administration, or duration of delirium or drug exposure. We defined critically ill patients as those treated in an ICU of any specialty (e.g. burn, cardiac, medical, surgical, trauma) or high-dependency unit. DATA COLLECTION AND ANALYSIS: Two review authors independently identified studies from the search results; four review authors (in pairs) performed data extraction and assessed risk of bias independently. We performed data synthesis through pairwise meta-analysis and network meta-analysis (NMA). Our hypothetical network structure was designed to be analysed at the drug class level and illustrated a network diagram of ‘nodes’ (i.e. drug classes) and ‘edges’ (i.e. comparisons between different drug classes from existing trials), thus describing a treatment network of all possible comparisons between drug classes. We assessed the quality of the body of evidence according to GRADE, as very low, low, moderate, or high. MAIN RESULTS: We screened 7674 citations, from which 14 trials with 1844 participants met our inclusion criteria. Ten RCTs were placebo-controlled, and four reported comparisons of different drugs. Drugs examined in these trials were the following: antipsychotics (n = 10), alpha2 agonists (n = 3; all dexmedetomidine), statins (n = 2), opioids (n = 1; morphine), serotonin antagonists (n = 1; ondansetron), and cholinesterase (CHE) inhibitors (n = 1; rivastigmine). Only one of these trials consistently used non-pharmacological interventions that are known to improve patient outcomes in both intervention and control groups.Eleven studies (n = 1153 participants) contributed to analysis of the primary outcome. Results of the NMA showed that the intervention with the smallest ratio of means (RoM) (i.e. most preferred) compared with placebo was the alpha2 agonist dexmedetomidine (0.58; 95% credible interval (CrI) 0.26 to 1.27; surface under the cumulative ranking curve (SUCRA) 0.895; moderate-quality evidence). In order of descending SUCRA values (best to worst), the next best interventions were atypical antipsychotics (RoM 0.80, 95% CrI 0.50 to 1.11; SUCRA 0.738; moderate-quality evidence), opioids (RoM 0.88, 95% CrI 0.37 to 2.01; SUCRA 0.578; very-low quality evidence), and typical antipsychotics (RoM 0.96, 95% CrI 0.64 to1.36; SUCRA 0.468; high-quality evidence).The NMAs of multiple secondary outcomes revealed that only the alpha2 agonist dexmedetomidine was associated with a shorter duration of mechanical ventilation (RoM 0.55, 95% CrI 0.34 to 0.89; moderate-quality evidence), and the CHE inhibitor rivastigmine was associated with a longer ICU stay (RoM 2.19, 95% CrI 1.47 to 3.27; moderate-quality evidence). Adverse events often were not reported in these trials or, when reported, were rare; pair-wise analysis of QTc prolongation in seven studies did not show significant differences between antipsychotics, ondansetron, dexmedetomidine, and placebo. AUTHORS’ CONCLUSIONS: We identified trials of varying quality that examined six different drug classes for treatment of delirium in critically ill adults. We found evidence that the alpha2 agonist dexmedetomidine may shorten delirium duration, although this small effect (compared with placebo) was seen in pairwise analyses based on a single study and was not seen in the NMA results. Alpha2 agonists also ranked best for duration of mechanical ventilation and length of ICU stay, whereas the CHE inhibitor rivastigmine was associated with longer ICU stay. We found no evidence of a difference between placebo and any drug in terms of delirium-free and coma-free days, days with coma, physical restraint use, length of stay, long-term cognitive outcomes, or mortality. No studies reported delirium relapse, resolution of symptoms, or quality of life. The ten ongoing studies and the six studies awaiting classification that we identified, once published and assessed, may alter the conclusions of the review.
- PMID
- Keywords
- Page(s)
- Volume
- 9
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| The influence of a serious game's narrative on students' attitudes and learning experiences regarding delirium: an interview study | Buijs-Spanjers, K. R. Harmsen, A. Hegge, H. H. Spook, J. E. de Rooij, S. E. Jaarsma, Dadc | BMC Med Educ | 2020 |
Delirium |
| Preoperative prognostic factors associated with postoperative delirium in older people undergoing surgery: protocol for a systematic review and individual patient data meta-analysis | Buchan, T. A. Sadeghirad, B. Schmutz, N. Goettel, N. Foroutan, F. Couban, R. Mbuagbaw, L. Dodsworth, B. T. | Syst Rev | 2020 |
Elderly |
| Impact of Therapeutic Music Listening on Intensive Care Unit Patients: A Pilot Study | Browning, S. G. Watters, R. Thomson-Smith, C. | Nurs Clin North Am | 2020 |
Aged |
| Association between delirium in the intensive care unit and subsequent neuropsychiatric disorders | Brown, K. N. Soo, A. Faris, P. Patten, S. B. Fiest, K. M. Stelfox, H. T. | Crit Care | 2020 |
Aged |
| Association of Positive Delirium Screening with Incident Dementia in Skilled Nursing Facilities | Briesacher, B. A. Koethe, B. Olivieri-Mui, B. Saczynski, J. S. Fick, D. M. Devlin, J. W. Marcantonio, E. R. | J Am Geriatr Soc | 2020 |
delirium |
| Economic Burden of Postoperative Neurocognitive Disorders Among US Medicare Patients | Boone, M. D. Sites, B. von Recklinghausen, F. M. Mueller, A. Taenzer, A. H. Shaefi, S. | JAMA Netw Open | 2020 |
Aged |
| Hospital Elder Life Program in Long-Term Care (HELP-LTC): A Cluster Randomized Controlled Trial | Boockvar, K. S. Judon, K. M. Eimicke, J. P. Teresi, J. A. Inouye, S. K. | J Am Geriatr Soc | 2020 |
delirium |
| Pain Incidence, Treatment, and Associated Symptoms in Hospitalized Persons with Dementia | Boltz, M. Resnick, B. Kuzmik, A. Mogle, J. Jones, J. R. Arendacs, R. BeLue, R. Cacchione, P. Galvin, J. E. | Pain Manag Nurs | 2020 | |
| Disparities in Physical and Psychological Symptoms in Hospitalized African American and White Persons with Dementia | Boltz, M. BeLue, R. Resnick, B. Kuzmik, A. Galik, E. Jones, J. R. Arendacs, R. Sinvani, L. Mogle, J. Galvin, J. E. | J Aging Health | 2020 |
African Americans |
| The prevalence rates and adversities of delirium: Too common and disadvantageous | Boettger, S. Zipser, C. M. Bode, L. Spiller, T. Deuel, J. Osterhoff, G. Ernst, J. Petry, H. Volbracht, J. von Känel, R. | Palliat Support Care | 2020 |
Delirium |
| Assessing delirium with nursing care instruments: Evaluation of the cognitive and associated domains | Bode, L. Fuchs, S. Gehrke, S. Ernst, J. Schubert, M. Nuñez, D. G. von Känel, R. Boettger, S. | Palliat Support Care | 2020 |
Assessment |
| Iranian Nurses Perception and Practices for Delirium Assessment in Intensive Care Units | Biyabanaki, F. Arab, M. Dehghan, M. | Indian J Crit Care Med | 2020 |
Assessment |
| How to fight against overtreatment? Example of neuroleptic prescriptions for acute delirium | Bianchi, C. Blondet, F. Aebischer, O. Méan, M. | Revue Medicale Suisse | 2020 |
neuroleptic agent |
| Clinical Presentation of COVID19 in Dementia Patients | Bianchetti, A. Rozzini, R. Guerini, F. Boffelli, S. Ranieri, P. Minelli, G. Bianchetti, L. Trabucchi, M. | Journal of Nutrition, Health and Aging | 2020 |
aged |
| Validation of two nurse-based screening tools for delirium in elderly patients in general medical wards | Bergjan, M. Zilezinski, M. Schwalbach, T. Franke, C. Erdur, H. Audebert, H. J. Hauß, A. | BMC Nurs | 2020 |
Confusion |
| Prevalence and management of delirium in intensive care units in the Netherlands: An observational multicentre study | Berger, E. Wils, E. J. Vos, P. van Santen, S. Koets, J. Slooter, A. J. C. van der Woude, M. Koopmans, M. Rinket, M. A. Hoiting, O. Hoogendoorn, E. E. Streefkerk, J. O. de Vreede, E. W. Riekerk, B. Simons, K. S. Toscano, E. Schoonderbeek, F. J. Hofstra, L. | Intensive Crit Care Nurs | 2020 |
Critically ill |
| Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial | Bellapart, J. Appadurai, V. Lassig-Smith, M. Stuart, J. Zappala, C. Boots, R. | Crit Care Res Pract | 2020 | |
| Delirium, functional decline and quality of life after transcatheter aortic valve implantation: An explorative study | Beishuizen, S. J. Festen, S. Loonstra, Y. E. van der Werf, H. W. de Rooij, S. E. van Munster, B. C. | Geriatr Gerontol Int | 2020 |
activities of daily living |
| Clinical outcomes in patients admitted to hospital with cervical spine fractures or with hip fractures | Baxter, J. Lisk, R. Osmani, A. Yeong, K. Robin, J. Fluck, D. Fry, C. H. Han, T. S. | Intern Emerg Med | 2020 |
Discharge destination |
| Frequency and Implications of Complications in the ICU After Status Epilepticus: No Calm After the Storm | Baumann, S. M. Semmlack, S. De Marchis, G. M. Hunziker, S. Rüegg, S. Marsch, S. Sutter, R. | Critical care medicine | 2020 |
adult |
| Neurological Complications and Noninvasive Multimodal Neuromonitoring in Critically Ill Mechanically Ventilated COVID-19 Patients | Battaglini, D. Santori, G. Chandraptham, K. Iannuzzi, F. Bastianello, M. Tarantino, F. Ball, L. Giacobbe, D. R. Vena, A. Bassetti, M. Inglese, M. Uccelli, A. Rocco, P. R. M. Patroniti, N. Brunetti, I. Pelosi, P. Robba, C. | Front Neurol | 2020 |
Covid-19 |
| Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study | Ballweg, T. White, M. Parker, M. Casey, C. Bo, A. Farahbakhsh, Z. Kayser, A. Blair, A. Lindroth, H. Pearce, R. A. Blennow, K. Zetterberg, H. Lennertz, R. Sanders, R. D. | Br J Anaesth | 2020 |
biomarker |
| Neurocovid: Pharmacological Recommendations for Delirium Associated With COVID-19 | Baller, E. B. Hogan, C. S. Fusunyan, M. A. Ivkovic, A. Luccarelli, J. W. Madva, E. Nisavic, M. Praschan, N. Quijije, N. V. Beach, S. R. Smith, F. A. | Psychosomatics | 2020 |
Adrenergic alpha-2 Receptor Agonists/ therapeutic use |
| An Implementation Assessment of the Virtual Acute Care for Elders Program From the Perspective of Key Stakeholders | Balentine, C. J. Morris, M. Knight, S. J. Turan, J. M. Flood, K. L. Gutierrez-Meza, D. Macdonald, C. L. Bhatia, S. Brown, C. J. | Ann Surg | 2020 | |
| The 'third wave': impending cognitive and functional decline in COVID-19 survivors | Baker, H. A. Safavynia, S. A. Evered, L. A. | Br J Anaesth | 2020 |
Covid-19 |
| Presence of urinary symptoms in bacteremic urinary tract infection: a retrospective cohort study of Escherichia coli bacteremia | Bai, A. D. Bonares, M. J. Thrall, S. Bell, C. M. Morris, A. M. | BMC Infect Dis | 2020 |
Aged |
| Risk Factors of Postoperative Delirium in Older Adult Spine Surgery Patients: A Meta-Analysis | Baek, W. Kim, Y. M. Lee, H. | AORN J | 2020 |
delirium |
| Psychosocial volunteer support for older adults with cognitive impairment: development of MyCare Ageing using a codesign approach via action research | Ayton, D. O'Donnell, R. Vicary, D. Bateman, C. Moran, C. Srikanth, V. K. Lustig, J. Banaszak-Holl, J. Hunter, P. Pritchard, E. Morris, H. Savaglio, M. Parikh, S. Skouteris, H. | BMJ Open | 2020 |
dementia |
| The Volunteer Dementia and Delirium Care (VDDC)©: A pre-implementation study exploring perceived acceptability to implementing the program in an acute and subacute metropolitan hospital | Ayton, D. Moran, C. Berkovic, D. Bateman, C. Anderson, K. Blair, A. Soh, S. E. Morello, R. Lim, Y. Y. Liew, D. | Australas J Ageing | 2020 |
delirium |
| A call to action for delirium research: Meta-analysis and regression of delirium associated mortality | Aung Thein, M. Z. Pereira, J. V. Nitchingham, A. Caplan, G. A. | BMC Geriatr | 2020 |
Aged |
| Accuracy and Feasibility of Clinically Applied Frailty Instruments before Surgery: A Systematic Review and Meta-analysis | Aucoin, S. D. Hao, M. Sohi, R. Shaw, J. Bentov, I. Walker, D. McIsaac, D. I. | Anesthesiology | 2020 |
Aged |
| Could COVID delirium bring on dementia? | Arnold, C. | Nature | 2020 |
COVID-19/ complications/epidemiology/ psychology |
| Neighborhood-Level Social Disadvantage and Risk of Delirium Following Major Surgery | Arias, F. Chen, F. Fong, T. G. Shiff, H. Alegria, M. Marcantonio, E. R. Gou, Y. Jones, R. N. Travison, T. G. Schmitt, E. M. Kind, A. J. H. Inouye, S. K. | J Am Geriatr Soc | 2020 |
Area Deprivation Index |
| Delirium is independently associated with early mortality in elderly patients starting hemodialysis | Arai, Y. Shioji, S. Tanaka, H. Kondo, I. Sakamoto, E. Suzuki, M. Katagiri, D. Tada, M. Hinoshita, F. | Clin Exp Nephrol | 2020 |
Chronic kidney disease |
| COVID-19 inpatients with psychiatric disorders: Real-world clinical recommendations from an expert team in consultation-liaison psychiatry | Anmella, G. Arbelo, N. Fico, G. Murru, A. Llach, C. D. Madero, S. Gomes-da-Costa, S. Imaz, M. L. López-Pelayo, H. Vieta, E. Pintor, L. | J Affect Disord | 2020 |
Aged |
| Relationship Between Intensive Care Unit Delirium Severity and 2-Year Mortality and Health Care Utilization | Andrews, P. S. Wang, S. Perkins, A. J. Gao, S. Khan, S. Lindroth, H. Boustani, M. Khan, B. | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2020 |
adult |
| Impact of a Pharmacist-Led Intensive Care Unit Sleep Improvement Protocol on Sleep Duration and Quality | Andrews, J. L. Louzon, P. R. Torres, X. Pyles, E. Ali, M. H. Du, Y. Devlin, J. W. | Ann Pharmacother | 2020 |
activity tracker |
| A Case of Concurrent Delirium and Catatonia in a Woman With Coronavirus Disease 2019 | Amouri, J. Andrews, P. S. Heckers, S. Ely, E. W. Wilson, J. E. | Psychosomatics | 2020 | |
| Delirium pathway: a North Hampshire experience | Al-Rawi, Y. A. | Progress in Neurology and Psychiatry | 2020 |
aged |
| Incidence and risk factors for acute delirium in older patients with a hip fracture: A retrospective cohort study | Aldwikat, R. K. Manias, E. Nicholson, P. | Nurs Health Sci | 2020 |
hip fracture |
| Delirium, insulin-like growth factor I, growth hormone in older inpatients | Adamis, D. Coada, I. Eikelenboom, P. Chu, C. S. Finn, K. Melvin, V. Williams, J. Meagher, D. J. McCarthy, G. | World J Psychiatry | 2020 |
Cognition |
| Critical Review and Meta-Analysis of Postoperative Sedation after Adult Cardiac Surgery: Dexmedetomidine Versus Propofol | Abowali, H. A. Paganini, M. Enten, G. Elbadawi, A. Camporesi, E. M. | J Cardiothorac Vasc Anesth | 2020 |
adult open cardiac surgery |
| Polypharmacy at admission prolongs length of hospitalization in gastrointestinal surgery patients | Abe, N. Kakamu, T. Kumagai, T. Hidaka, T. Masuishi, Y. Endo, S. Kasuga, H. Fukushima, T. | Geriatr Gerontol Int | 2020 |
Adult |
| Stroke-related delirium | Al-Khaled, M. | Journal of the Neurological Sciences | 2021 |
article |
| Practice Variability in Screening and Treating Pediatric Critical Illness Delirium: Survey | Aljabari, S. Carter, C. Waheed, S. Anderson, J. E. | Journal of Pediatric Intensive Care | 2020 |
child |
| Perioperative complications of pediatric otorhinolaryngological operations | Aleksandrovich, Y. Rybianov, V. Pshenisnov, K. V. Razumov, S. | Saudi Journal of Anaesthesia | 2020 |
Complications ENT Heart rate variability Pediatric Perioperative |
| Prevention as Intervention: Reducing Incident Delirium in Heart Failure | Albert, B. L. | Journal of doctoral nursing practice | 2019 |
acute heart failure |
| The prevalence of prescribing medications associated with geriatric syndromes among discharged elderly patients | Akkawi, M. E. Taufek, N. H. M. Hadi, A. D. A. Nik Lah, N. N. N. F. | Journal of Pharmacy and Bioallied Sciences | 2020 |
Elderly patients Geriatric Syndromes Medication prescribing |
| Incidence and predictors of delirium after cardiac arrest – A retrospective registry | Aicher, N. Jäckel, M. Faye, C. Wengenmayer, T. Bode, C. Staudacher, D. L. | Resuscitation | 2020 |
noradrenalin |
| Is ketamine safe for the pre-hospital sedation of patients with excited delirium secondary to sympathomimetic toxicity? | Adams, Y. | Australasian Journal of Paramedicine | 2019 |
adrenergic receptor stimulating agent |
| Prospective, multi-centric benchmark study assessing delirium: prevalence, incidence and its correlates in hospitalized elderly Lebanese patients | Zrour, C. Haddad, R. Zoghbi, M. Kharsa, Z. Hijazi, M. Naja, W. | Aging Clin Exp Res | 2020 |
Correlated factors |
| Knowledge and attitudes of adolescents with psychiatric disorders and their caregivers towards electroconvulsive therapy in China | Zong, Q. Q. Qi, H. Wang, Y. Y. Zhang, C. Balbuena, L. Ungvari, G. S. An, F. R. Xiang, Y. T. | Asian Journal of Psychiatry | 2020 |
adolescent |
| Does postoperative delirium following elective noncardiac surgery predict long-term mortality? | Ziman, N. Sands, L. P. Tang, C. Zhu, J. Leung, J. M. | Age Ageing | 2020 |
long-term mortality |
| Anxiety administrated by dexmedetomidine to prevent new-onset of postoperative atrial fibrillation in patients undergoing off-pump coronary artery bypass graft | Zi, J. Fan, Y. Dong, C. Zhao, Y. Li, D. Tan, Q. | International Heart Journal | 2020 |
1800014314 |
| Assessment of Melatonergics in Prevention of Delirium: A Systematic Review and Meta-Analysis | Zhu, Y. Jiang, Z. Huang, H. Li, W. Ren, C. Yao, R. Wang, Y. Yao, Y. Li, W. Du, B. Xi, X. | Front Neurol | 2020 |
critical care medicine |
| Geriatric Nutritional Risk Index can predict postoperative delirium and hospital length of stay in elderly patients undergoing non-cardiac surgery | Zhao, Y. Xia, X. Xie, D. Liao, Y. Wang, Y. Chen, L. Ge, N. Yue, J. | Geriatr Gerontol Int | 2020 |
Geriatric Nutritional Risk Index |
| The geriatric nutrition risk index versus the mini-nutritional assessment short form in predicting postoperative delirium and hospital length of stay among older non-cardiac surgical patients: a prospective cohort study | Zhao, Y. Ge, N. Xie, D. Gao, L. Wang, Y. Liao, Y. Yue, J. | BMC Geriatr | 2020 |
Geriatric nutritional risk index |
| Perioperative Multicomponent Interdisciplinary Program Reduces Delirium Incidence in Elderly Patients With Hip Fracture | Zhao, X. Yuan, W. | J Am Psychiatr Nurses Assoc | 2020 |
delirium |
| Emergence delirium is associated with increased postoperative delirium in elderly: a prospective observational study | Zhang, Y. He, S. T. Nie, B. Li, X. Y. Wang, D. X. | J Anesth | 2020 |
Elderly |
| S100β as a potential biomarker of incident delirium: a systematic review and meta-analysis | Zhang, X. Lyu, Y. Wang, D. | Minerva Anestesiol | 2020 | |
| Effects of Dexmedetomidine on Postoperative Delirium and Expression of IL-1β, IL-6, and TNF-α in Elderly Patients After Hip Fracture Operation | Zhang, W. Wang, T. Wang, G. Yang, M. Zhou, Y. Yuan, Y. | Front Pharmacol | 2020 |
dexmedetomidine |
| Nomogram Model for Predicting Risk of Postoperative Delirium After Deep Brain Stimulation Surgery in Patients Older Than 50 Years with Parkinson Disease | Zhan, L. Wang, X. Q. Zhang, L. X. | World Neurosurg | 2020 |
Advanced age |
| Combining Ultrafast Anaesthesia and Minimal Invasive Implantation in HeartMate 3: A Pilot Study | Zayat, R. Ahmad, U. Twarie, L. Moza, A. Schaelte, G. Allham, O. Haneya, A. Khattab, M. Schnoering, H. Autschbach, R. | The Journal of heart and lung transplantation | 2020 |
adult |
| Exosome α-Synuclein Release in Plasma May be Associated With Postoperative Delirium in Hip Fracture Patients | Yuan, Y. Li, Z. Yang, N. Han, Y. Ji, X. Han, D. Wang, X. Li, Y. Liu, T. Yuan, F. He, J. Liu, Y. Ni, C. Zou, P. Wang, G. Guo, X. Zhou, Y. | Front Aging Neurosci | 2020 |
exosome |
| A multicentre, pragmatic, cluster randomised, controlled feasibility trial of the POD system of care | Young, J. Green, J. Farrin, A. Collinson, M. Hartley, S. Smith, J. Teale, E. Siddiqi, N. Inouye, S. K. | Age Ageing | 2020 |
delirium |
| Association of Reversal of Anticoagulation Preoperatively on 30-Day Mortality and Outcomes for Hip Fracture Surgery | Yoo, M. S. Zhu, S. Jiang, S. F. Hammer, H. L. McBride, W. J. McCarthy, C. M. Green, C. E. Ananias, M. P. | American Journal of Medicine | 2020 |
adult |
| Perioperative Complications and Prognosis of Curative Surgical Resection for Spinal Metastases in Elderly Patients | Yonezawa, N. Murakami, H. Demura, S. Kato, S. Yoshioka, K. Shinmura, K. Yokogawa, N. Shimizu, T. Oku, N. Kitagawa, R. Handa, M. Annen, R. Kurokawa, Y. Tsuchiya, H. | World Neurosurgery | 2020 |
titanium cage |
| Risk factors for delirium in intensive care unit and its duration | Yanyan, L. Dajiang, Y. Xiaoya, L. Shao, W. | Zhonghua Wei Zhong Bing Ji Jiu Yi Xue | 2020 |
sedative agent |
| Melatonergic agents in the prevention of delirium: A network meta-analysis of randomized controlled trials | Yang, C. P. Tseng, P. T. Pei-Chen Chang, J. Su, H. Satyanarayanan, S. K. Su, K. P. | Sleep Med Rev | 2020 |
Delirium |
| Oxycodone preemptive analgesia after endoscopic plasma total adenotonsillectomy in children a randomized controlled trial | Wu, J. Gui, Q. Wang, J. Ye, J. Xia, Z. Wang, S. Liu, F. Kong, F. Zhong, L. | Medicine (United States) | 2020 |
ChiCTR-INR-16009116 |
| Delirium screening practice in specialist palliative care units: a survey | Woodhouse, R. Siddiqi, N. Boland, J. W. Featherstone, I. Johnson, M. J. | BMJ Support Palliat Care | 2020 |
delirium |
| Movements and trends in intensive care pain treatment and sedation: What matters to the patient? | Wøien, H. | J Clin Nurs | 2020 |
Adult |
| Quetiapine therapy in critically injured trauma patients is associated with an increased risk of pulmonary complications | Wessels, L. E. Wallace, J. D. Calvo, R. Y. Levko, T. Bowie, J. M. Butler, W. J. Bansal, V. Sise, C. B. Martin, M. J. Sise, M. J. | Am J Surg | 2020 |
Antipsychotic Agents/ adverse effects |
| Combined non-intubated anaesthesia and paravertebral nerve block in comparison with intubated anaesthesia in children undergoing video-assisted thoracic surgery | Wei, W. Fan, Y. Liu, W. Zhao, T. Tian, H. Xu, Y. Tan, Y. Song, X. Ma, D. | Acta Anaesthesiol Scand | 2020 | |
| The occurrence and timing of delirium in acute care hospitalizations in the last year of life: A population-based retrospective cohort study | Webber, C. Watt, C. L. Bush, S. H. Lawlor, P. G. Talarico, R. Tanuseputro, P. | Palliat Med | 2020 |
Delirium |
| Frailty screening in hospitalised older adults: How does the brief Dutch National Safety Management Program perform compared to a more extensive approach? | Warnier, R. M. J. van Rossum, E. van Kuijk, S. M. J. Magdelijns, F. Schols, Jmga Kempen, Gijm | J Clin Nurs | 2020 |
Aged |
| Predicting postoperative delirium after microvascular decompression surgery with machine learning | Wang, Y. Lei, L. Ji, M. Tong, J. Zhou, C. M. Yang, J. J. | J Clin Anesth | 2020 |
Machine learning |
| Propensity score-adjusted three-component mixture model for drug-drug interaction data mining in FDA Adverse Event Reporting System | Wang, X. Li, L. Wang, L. Feng, W. Zhang, P. | Statistics in Medicine | 2020 |
amfebutamone |
| Comparison between Dexmedetomidine and Midazolam for Sedation in Patients with Intubation after Oral and Maxillofacial Surgery | Wang, L. Zhang, T. Huang, L. Peng, W. | Biomed Res Int | 2020 | |
| Comparison of Intranasal Dexmedetomidine and Oral Midazolam for Premedication in Pediatric Dental Patients under General Anesthesia: A Randomised Clinical Trial | Wang, L. Huang, L. Zhang, T. Peng, W. | Biomed Res Int | 2020 | |
| Accelerated magnetic seizure therapy (aMST) for treatment of major depressive disorder: A pilot study | Wang, J. Vila-Rodriguez, F. Ge, R. Gao, S. Gregory, E. Jiang, W. Yang, C. Wang, G. | J Affect Disord | 2020 |
Cognition |
| Development and validation of the delirium risk assessment score (DRAS) | Vreeswijk, R. Kalisvaart, I. Maier, A. B. Kalisvaart, K. J. | Eur Geriatr Med | 2020 |
Delirium |
| Development and validation of the delirium risk assessment score (DRAS) | Vreeswijk, R. Kalisvaart, I. Maier, A. B. Kalisvaart, K. J. | Eur Geriatr Med | 2020 |
Delirium |
| Hospital readmission following transjugular intrahepatic portosystemic shunt: A 14-year single-center experience | Vozzo, C. F. Singh, T. Bullen, J. Sarvepalli, S. McCullough, A. Kapoor, B. | Gastroenterology Report | 2020 |
politef implant |
| Anticholinergic drug exposure at intensive care unit admission affects the occurrence of delirium. A prospective cohort study | Vondeling, A. M. Knol, W. Egberts, T. C. G. Slooter, A. J. C. | Eur J Intern Med | 2020 |
Anticholinergics |
| Delirium Screening in Neurocritical Care and Stroke Unit Patients: A Pilot Study on the Influence of Neurological Deficits on CAM-ICU and ICDSC Outcome | von Hofen-Hohloch, J. Awissus, C. Fischer, M. M. Michalski, D. Rumpf, J. J. Classen, J. | Neurocrit Care | 2020 |
Cam-icu |
| Intensive Care Unit Delirium in Surgical Patients Is Associated with Upregulation in Tryptophan Metabolism | Voils, S. A. Shoulders, B. R. Singh, S. Solberg, L. M. Garrett, T. J. Frye, R. F. | Pharmacotherapy | 2020 |
critical care |
| Vitamin D and Postoperative Delirium After Coronary Artery Bypass Grafting: A Prospective Cohort Study | Velayati, A. Vahdat Shariatpanahi, M. Dehghan, S. Zayeri, F. Vahdat Shariatpanahi, Z. | Journal of Cardiothoracic and Vascular Anesthesia | 2020 |
adult |
| New Delirium Severity Indicators: Generation and Internal Validation in the Better Assessment of Illness (BASIL) Study | Vasunilashorn, S. M. Schulman-Green, D. Tommet, D. Fong, T. G. Hshieh, T. T. Marcantonio, E. R. Metzger, E. D. Schmitt, E. M. Tabloski, P. A. Travison, T. G. Gou, Y. Helfand, B. Inouye, S. K. Jones, R. N. | Dement Geriatr Cogn Disord | 2020 |
Delirium |
| A New Severity Scoring Scale for the 3-Minute Confusion Assessment Method (3D-CAM) | Vasunilashorn, S. M. Devinney, M. J. Acker, L. Jung, Y. Ngo, L. Cooter, M. Huang, R. Marcantonio, E. R. Berger, M. | J Am Geriatr Soc | 2020 | |
| Use of a digital delirium pathway and quality improvement to improve delirium detection in the emergency department and outcomes in an acute hospital | Vardy, E. Collins, N. Grover, U. Thompson, R. Bagnall, A. Clarke, G. Heywood, S. Thompson, B. Wintle, L. Nutt, L. Hulme, S. | Age Ageing | 2020 |
acute |
| Registration of attentional function as a predictor of incident delirium (the RAPID study) | van Zuylen, M. L. Hermanides, J. Ten Hoope, W. Preckel, B. van de Beek, D. van Gool, W. A. Schoenmaker, N. | Alzheimers Dement (N Y) | 2020 |
attentional function |
| Predisposition for delirium and EEG characteristics | van Montfort, S. J. T. van Dellen, E. Wattel, L. L. Kant, I. M. J. Numan, T. Stam, C. J. Slooter, A. J. C. | Clin Neurophysiol | 2020 |
Delirium |
| Geriatric assessment in the prediction of delirium and long-term survival after transcatheter aortic valve implantation | van der Wulp, K. van Wely, M. H. Schoon, Y. Vart, P. Olde Rikkert, M. G. M. Morshuis, W. J. van Royen, N. Verkroost, M. W. A. Gehlmann, H. R. Van Garsse, L. A. F. M. Kievit, P. C. | Journal of Thoracic and Cardiovascular Surgery | 2020 |
aged |
| Complications with focus on delirium during hospital stay related to femoral nerve block compared to conventional pain management among patients with hip fracture – A randomised controlled trial | Unneby, A. Svensson, P. O. Gustafson, P. Y. Lindgren, A. P. B. M. Bergström, U. Olofsson, P. B. | Injury | 2020 |
aged |
| Preoperative Vitamin D Level is Associated with Postoperative Delirium After Cardiac Surgery in Patients Over 65 Years of Age | Tumer, N. B. Tekeli Kunt, A. Gunaydin, S. Ozisik, K. | Heart Surg Forum | 2020 | |
| Epileptic seizure discharges in patients after open chamber cardiac surgery—a prospective prevalence pilot study using continuous electroencephalography | Tschernatsch, M. Juenemann, M. Alhaidar, F. El Shazly, J. Butz, M. Meyer, M. Gerriets, T. Schönburg, M. Schramm, P. | Intensive Care Medicine | 2020 |
adult |
| Pharmacogenomic response of low dose haloperidol in critically ill adults with delirium | Trogrlić, Z. van der Jagt, M. Osse, R. J. Devlin, J. W. Nieboer, D. Koch, B. C. P. van Schaik, R. H. N. Hunfeld, N. G. M. | J Crit Care | 2020 |
Delirium |
| The Impact of Music and Noise-Cancellation on Sedation Requirements During Total Knee Replacement: A Randomized Controlled Trial | Tran, B. W. Nowrouz, M. Y. Dhillon, S. K. Xie, K. K. Breslin, K. M. Golladay, G. J. | Geriatr Orthop Surg Rehabil | 2020 |
acute pain medicine |
| The Prevalence and Impact of Undiagnosed Mild Cognitive Impairment in Elderly Patients Undergoing Thoracic Surgery: A Prospective Cohort Study | Tong, C. Huang, C. Wu, J. Xu, M. Cao, H. | J Cardiothorac Vasc Anesth | 2020 |
Mild cognitive impairment |