What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.
- Authors
- Miller, D. Lewis, S. R. Pritchard, M. W. Schofield-Robinson, O. J. Shelton, C. L. Alderson, P. Smith, A. F.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
BACKGROUND: The use of anaesthetics in the elderly surgical population (more than 60 years of age) is increasing. Postoperative delirium, an acute condition characterized by reduced awareness of the environment and a disturbance in attention, typically occurs between 24 and 72 hours after surgery and can affect up to 60% of elderly surgical patients. Postoperative cognitive dysfunction (POCD) is a new-onset of cognitive impairment which may persist for weeks or months after surgery.Traditionally, surgical anaesthesia has been maintained with inhalational agents. End-tidal concentrations require adjustment to balance the risks of accidental awareness and excessive dosing in elderly people. As an alternative, propofol-based total intravenous anaesthesia (TIVA) offers a more rapid recovery and reduces postoperative nausea and vomiting. Using TIVA with a target controlled infusion (TCI) allows plasma and effect-site concentrations to be calculated using an algorithm based on age, gender, weight and height of the patient.TIVA is a viable alternative to inhalational maintenance agents for surgical anaesthesia in elderly people. However, in terms of postoperative cognitive outcomes, the optimal technique is unknown. OBJECTIVES: To compare maintenance of general anaesthesia for elderly people undergoing non-cardiac surgery using propofol-based TIVA or inhalational anaesthesia on postoperative cognitive function, mortality, risk of hypotension, length of stay in the postanaesthesia care unit (PACU), and hospital stay. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2017, Issue 11), MEDLINE (1946 to November 2017), Embase (1974 to November 2017), PsycINFO (1887 to November 2017). We searched clinical trials registers for ongoing studies, and conducted backward and forward citation searching of relevant articles. SELECTION CRITERIA: We included randomized controlled trials (RCTs) with participants over 60 years of age scheduled for non-cardiac surgery under general anaesthesia. We planned to also include quasi-randomized trials. We compared maintenance of anaesthesia with propofol-based TIVA versus inhalational maintenance of anaesthesia. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed studies for inclusion, extracted data, assessed risk of bias, and synthesized findings. MAIN RESULTS: We included 28 RCTs with 4507 randomized participants undergoing different types of surgery (predominantly cardiovascular, laparoscopic, abdominal, orthopaedic and ophthalmic procedures). We found no quasi-randomized trials. Four studies are awaiting classification because we had insufficient information to assess eligibility.All studies compared maintenance with propofol-based TIVA versus inhalational maintenance of anaesthesia. Six studies were multi-arm and included additional TIVA groups, additional inhalational maintenance or both. Inhalational maintenance agents included sevoflurane (19 studies), isoflurane (eight studies), and desflurane (three studies), and was not specified in one study (reported as an abstract). Some studies also reported use of epidural analgesia/anaesthesia, fentanyl and remifentanil.We found insufficient reporting of randomization methods in many studies and all studies were at high risk of performance bias because it was not feasible to blind anaesthetists to study groups. Thirteen studies described blinding of outcome assessors. Three studies had a high of risk of attrition bias, and we noted differences in the use of analgesics between groups in six studies, and differences in baseline characteristics in five studies. Few studies reported clinical trials registration, which prevented assessment of risk of selective reporting bias.We found no evidence of a difference in incidences of postoperative delirium according to type of anaesthetic maintenance agents (odds ratio (OR) 0.59, 95% confidence interval (CI) 0.15 to 2.26; 321 participants; five studies; very low-certainty evidence); we noted during sensitivity analysis that using different time points in one study may influence direction of this result. Thirteen studies (3215 participants) reported POCD, and of these, six studies reported data that could not be pooled; we noted no difference in scores of POCD in four of these and in one study, data were at a time point incomparable to other studies. We excluded one large study from meta-analysis because study investigators had used non-standard anaesthetic management and this study was not methodologically comparable to other studies. We combined data for seven studies and found low-certainty evidence that TIVA may reduce POCD (OR 0.52, 95% CI 0.31 to 0.87; 869 participants).We found no evidence of a difference in mortality at 30 days (OR 1.21, 95% CI 0.33 to 4.45; 271 participants; three studies; very low-certainty evidence). Twelve studies reported intraoperative hypotension. We did not perform meta-analysis for 11 studies for this outcome. We noted visual inconsistencies in these data, which may be explained by possible variation in clinical management and medication used to manage hypotension in each study (downgraded to low-certainty evidence); one study reported data in a format that could not be combined and we noted little or no difference between groups in intraoperative hypotension for this study. Eight studies reported length of stay in the PACU, and we did not perform meta-analysis for seven studies. We noted visual inconsistencies in these data, which may be explained by possible differences in definition of time points for this outcome (downgraded to very low-certainty evidence); data were unclearly reported in one study. We found no evidence of a difference in length of hospital stay according to type of anaesthetic maintenance agent (mean difference (MD) 0 days, 95% CI -1.32 to 1.32; 175 participants; four studies; very low-certainty evidence).We used the GRADE approach to downgrade the certainty of the evidence for each outcome. Reasons for downgrading included: study limitations, because some included studies insufficiently reported randomization methods, had high attrition bias, or high risk of selective reporting bias; imprecision, because we found few studies; inconsistency, because we noted heterogeneity across studies. AUTHORS’ CONCLUSIONS: We are uncertain whether maintenance with propofol-based TIVA or with inhalational agents affect incidences of postoperative delirium, mortality, or length of hospital stay because certainty of the evidence was very low. We found low-certainty evidence that maintenance with propofol-based TIVA may reduce POCD. We were unable to perform meta-analysis for intraoperative hypotension or length of stay in the PACU because of heterogeneity between studies. We identified 11 ongoing studies from clinical trials register searches; inclusion of these studies in future review updates may provide more certainty for the review outcomes.
- PMID
- Keywords
Aged
Anesthesia, Inhalation
Anesthesia, Intravenous
Anesthetics, Inhalation
Anesthetics, Intravenous/*adverse effects
Cognition/*drug effects
Cognition Disorders/chemically induced
Delirium/chemically induced
Desflurane
Humans
Hypotension/chemically induced
Isoflurane/adverse effects/analogs & derivatives
Methyl Ethers/adverse effects
Middle Aged
Postoperative Complications/chemically induced/mortality
Propofol/*adverse effects
Randomized Controlled Trials as Topic
Sevoflurane
*Surgical Procedures, Operative
- Page(s)
- Volume
- 8
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Patterns of Potentially Inappropriate Bladder Antimuscarinic Use in People with Dementia: A Retrospective Cohort Study | Green, A. R. Segal, J. Boyd, C. M. Huang, J. Roth, D. L. | Drugs Real World Outcomes | 2020 | |
| Incidence, determinants and consequences of delirium in older patients after transcatheter aortic valve implantation | Goudzwaard, J. A. de Ronde-Tillmans, Mjag de Jager, T. A. J. Lenzen, M. J. Nuis, R. J. van Mieghem, N. M. Daemen, J. de Jaegere, P. P. T. Mattace-Raso, F. U. S. | Age Ageing | 2020 |
aortic stenosis |
| Neuromonitoring of delirium with quantitative pupillometry in sedated mechanically ventilated critically ill patients | Favre, E. Bernini, A. Morelli, P. Pasquier, J. Miroz, J. P. Abed-Maillard, S. Ben-Hamouda, N. Oddo, M. | Crit Care | 2020 |
Cholinergic |
| Cognitive Outcomes of Long-term Benzodiazepine and Related Drug (BDZR) Use in People Living With Mild to Moderate Alzheimer's Disease: Results From NILVAD | Dyer, A. H. Murphy, C. Lawlor, B. Kennelly, S. P. | J Am Med Dir Assoc | 2020 |
Dementia |
| 'Nonagenarians' with a hip fracture: is a different orthogeriatric treatment strategy necessary? | de Groot, R. Nijmeijer, W. S. Folbert, E. C. Vollenbroek-Hutten, M. M. R. Hegeman, J. H. | Arch Osteoporos | 2020 |
Frail elderly |
| Comparison of single minimum dose administration of dexmedetomidine and midazolam for prevention of emergence delirium in children: a randomized controlled trial | Cho, E. A. Cha, Y. B. Shim, J. G. Ahn, J. H. Lee, S. H. Ryu, K. H. | J Anesth | 2020 |
Dexmedetomidine |
| Innovative care models across settings: Providing nursing care to older adults | Cacchione, P. Z. | Geriatr Nurs | 2020 |
Evercare/Optum |
| Is the bispectral index monitoring protective against postoperative cognitive decline? A systematic review with meta-analysis | Bocskai, T. Kovacs, M. Szakacs, Z. Gede, N. Hegyi, P. Varga, G. Pap, I. Toth, I. Revesz, P. Szanyi, I. Nemeth, A. Gerlinger, I. Karadi, K. Lujber, L. | PLoS One | 2020 |
Anesthesia |
| Postanesthesia care unit delirium following robot-assisted vs open retropubic radical prostatectomy: A prospective observational study | Beck, S. Hoop, D. Ragab, H. Rademacher, C. Messner-Schmitt, A. von Breunig, F. Haese, A. Graefen, M. Zollner, C. Fischer, M. | Int J Med Robot | 2020 |
Trendelenburg position |
| The impact of Hospital Elder Life Program interventions, on 30-day readmission Rates of older hospitalized patients | Zachary, W. Kirupananthan, A. Cotter, S. Barbara, G. H. Cooke, R. C., 3rd Sipho, M. | Arch Gerontol Geriatr | 2020 |
Cost savings |
| Prevalence and risk factors for postoperative delirium in patients with colorectal carcinoma: a systematic review and meta-analysis | Yang, Z. Wang, X. F. Yang, L. F. Fang, C. Gu, X. K. Guo, H. W. | Int J Colorectal Dis | 2020 |
Coloretal cancer |
| Incidence, risk factors, and outcomes for sepsis-associated delirium in patients with mechanical ventilation: A sub-analysis of a multicenter randomized controlled trial | Yamamoto, T. Mizobata, Y. Kawazoe, Y. Miyamoto, K. Ohta, Y. Morimoto, T. Yamamura, H. | Journal of Critical Care | 2020 |
fentanyl |
| Effects of different BP management strategies on postoperative delirium in elderly patients undergoing hip replacement: A single center randomized controlled trial | Xu, X. Hu, X. Wu, Y. Li, Y. Zhang, Y. Zhang, M. Yang, Q. | J Clin Anesth | 2020 |
Blood pressure |
| Preoperative prognostic nutritional index predicts postoperative delirium in elderly patients after hip fracture surgery | Xing, H. Xiang, D. Li, Y. Ji, X. Xie, G. | Psychogeriatrics | 2020 |
elderly |
| The effects of early femoral nerve block intervention on preoperative pain management and incidence of postoperative delirium geriatric patients undergoing trochanteric femur fracture surgery: A randomized controlled trial | Uysal, A. I. Altiparmak, B. Yasar, E. Turan, M. Canbek, U. Yilmaz, N. Gumus Demirbilek, S. | Ulus Travma Acil Cerrahi Derg | 2020 | |
| A smartphone-based test for the assessment of attention deficits in delirium: A case-control diagnostic test accuracy study in older hospitalised patients | Tieges, Z. Stott, D. J. Shaw, R. Tang, E. Rutter, L. M. Nouzova, E. Duncan, N. Clarke, C. Weir, C. J. Assi, V. Ensor, H. Barnett, J. H. Evans, J. Green, S. Hendry, K. Thomson, M. McKeever, J. Middleton, D. G. Parks, S. Walsh, T. Weir, A. J. Wilson, E. Qua | PLoS One | 2020 | |
| A 'real-world' analysis of risk factors for post liver transplant delirium and the effect on length of stay | Tavabie, O. D. Colwill, M. Adamson, R. McPhail, M. J. W. Bernal, W. Jassem, W. Prachialias, A. Heneghan, M. Aluvihare, V. R. Agarwal, K. | Eur J Gastroenterol Hepatol | 2020 | |
| Intraoperative hypotension and delirium in patients with hip fracture | Tantardini, V. Roca, F. Bahri, O. Compere, V. Dujardin, F. Chassagne, P. | Geriatr Psychol Neuropsychiatr Vieil | 2020 |
anaesthesia |
| Evaluation of emergence agitation after general anaesthesia in rhinoplasty patients: Inhalation anaesthesia versus total intravenous anaesthesia | Talih, G. Yüksek, A. Şahin, E. | American Journal of Otolaryngology - Head and Neck Medicine and Surgery | 2020 |
adult |
| Implementation of a multiprofessional, multicomponent delirium management guideline in two intensive care units, and its effect on patient outcomes and nurse workload: a pre-post design retrospective cohort study | Schubert, M. Bettex, D. Steiger, P. Schurch, R. Haller, A. Bogdanovic, J. Garcia Nunez, D. Schwarz, U. Siegemund, M. | Swiss Med Wkly | 2020 | |
| Cerebrospinal Fluid Levels of Interleukin-8 in Delirium, Dementia, and Cognitively Healthy Patients | Sajjad, M. U. Blennow, K. Knapskog, A. B. Idland, A. V. Chaudhry, F. A. Wyller, T. B. Zetterberg, H. Watne, L. O. | J Alzheimers Dis | 2020 |
Alzheimer’s disease |
| Prehospital Anticholinergic Burden Is Associated With Delirium but Not With Mortality in a Population of Acutely Ill Medical Patients | Rigor, J. Rueff Rato, I. Ferreira, P. M. Pereira, R. Ribeiro, C. Teixeira, D. Mesquita Oliveira, P. Silva, A. M. Pereira, S. Costa, I. Ferreira, P. Sequeira, M. Monteiro-Soares, M. Martins-Mendes, D. | J Am Med Dir Assoc | 2020 |
Anticholinergic |
| Impact of Vitamin C and Thiamine Administration on Delirium-Free Days in Patients with Septic Shock | Park, J. E. Shin, T. G. Jo, I. J. Jeon, K. Suh, G. Y. Park, M. Won, H. Chung, C. R. Hwang, S. Y. | J Clin Med | 2020 |
delirium |
| Evaluation of an updated sedation protocol to reduce benzodiazepines in a pediatric intensive care unit | Michel, J. Hofbeck, M. Peper, A. K. Kumpf, M. Neunhoeffer, F. | Curr Med Res Opin | 2020 |
Cardiac surgery |
| A qualitative exploration of the views of patients and their relatives regarding interventions to minimize the distress related to postoperative delirium | Meilak, C. Biswell, E. Willis, R. Partridge, J. Dhesi, J. | Int J Geriatr Psychiatry | 2020 |
aged |
| Incidence and risk factors of postoperative delirium in elderly patients undergoing urological surgery: A multi-institutional prospective study | Matsuki, M. Tanaka, T. Takahashi, A. Inoue, R. Hotta, H. Itoh, N. Taguchi, K. Kato, R. Kobayashi, K. Masumori, N. | Int J Urol | 2020 |
elderly patients |
| Still Predicting Delirium After All These Years | Marcantonio, ER | Anesth Analg | 2020 | |
| Ketamine sedation in mechanically ventilated patients: A systematic review and meta-analysis | Manasco, A. T. Stephens, R. J. Yaeger, L. H. Roberts, B. W. Fuller, B. M. | Journal of Critical Care | 2020 |
fentanyl |
| A Study of the Psychometric Properties of the “Stanford Proxy Test for Delirium” (S-PTD): A New Screening Tool for the Detection of Delirium | Maldonado, J. R. Sher, Y. I. Benitez-Lopez, M. A. Savant, V. Garcia, R. Ament, A. De Guzman, E. | Psychosomatics | 2020 |
adult |
| Risk factors for postoperative delirium after colorectal surgery: a systematic review and meta-analysis | Lee, S. H. Lim, S. W. | Int J Colorectal Dis | 2020 |
Colorectal surgery |
| Results from a double blinded, randomized, placebo-controlled, feasibility trial of melatonin for the treatment of delirium in older medical inpatients | Lange, P. W. Clayton-Chubb, D. I. Watson, R. Maier, A. B. | Intern Med J | 2020 |
Delirium |
| Risk factors and outcomes among delirium subtypes in adult ICUs: A systematic review | Krewulak, K. D. Stelfox, H. T. Ely, E. W. Fiest, K. M. | J Crit Care | 2020 |
Critical care |
| Survey of analgesia and sedation in pediatric intensive care units in Japan | Koizumi, T. Kurosawa, H. | Pediatr Int | 2020 |
analgesia |
| Association of neuronal repair biomarkers with delirium among survivors of critical illness | Hayhurst, C. J. Patel, M. B. McNeil, J. B. Girard, T. D. Brummel, N. E. Thompson, J. L. Chandrasekhar, R. Ware, L. B. Pandharipande, P. P. Ely, E. W. Hughes, C. G. | Journal of Critical Care | 2020 |
NCT00392795 |
| Dexmedetomidine's Relationship to Delirium in Patients Undergoing Cardiac Surgery: A Systematic Review | Halpin, E. Inch, H. O'Neill, M. | Crit Care Nurs Q | 2020 | |
| Management of delirium at an academic medical center: Plans for antipsychotic prescribing upon discharge | Halavonich, L. Robert, S. McGraw, D. Weeda, E. Mullinax, K. Bass, B. | Ment Health Clin | 2020 |
antipsychotic |
| Association Between Level of Arousal and 30-Day Survival in Acutely Ill Older Adults | Garcez, F. B. Jacob-Filho, W. Avelino-Silva, T. J. | J Am Med Dir Assoc | 2020 |
Delirium |
| Drug therapy for delirium in terminally ill adults | Finucane, A. M. Jones, L. Leurent, B. Sampson, E. L. Stone, P. Tookman, A. Candy, B. | Cochrane Database Syst Rev | 2020 | |
| Delirium in patients with hip fracture is associated with increased heart rate variability | Ernst, G. Watne, L. O. Rostrup, M. Neerland, B. E. | Aging Clin Exp Res | 2020 |
Autonomic nervous system |
| Risk factors for delirium after esophagectomy | Dezube, A. R. Bravo-Iniguez, C. E. Yelamanchili, N. De Leon, L. E. Tarascio, J. Jaklitsch, M. T. Wee, J. O. | J Surg Oncol | 2020 |
delirium |
| Delirium in a Tertiary PICU: Risk Factors and Outcomes | Dervan, L. A. Di Gennaro, J. L. Farris, R. W. D. Watson, R. S. | Pediatr Crit Care Med | 2020 | |
| Validity and Reliability of the Brazilian Portuguese Version of the Pediatric Confusion Assessment Method for the ICU | de Castro, R. E. V. Prata-Barbosa, A. de Magalhaes-Barbosa, M. C. Cunha, Ajlad Cheniaux, E. Smith, H. A. B. | Pediatr Crit Care Med | 2020 | |
| Outcomes for patients with delirium receiving hospital-in-the-home treatment: An Australian perspective | Chia, J. Eeles, E. M. Tattam, K. Yerkovich, S. | Australas J Ageing | 2020 |
delirium |
| A software to prevent delirium in hospitalised older adults: development and feasibility assessment | Alvarez, E. A. Garrido, M. Ponce, D. P. Pizarro, G. Cordova, A. A. Vera, F. Ruiz, R. Fernandez, R. Velasquez, J. D. Tobar, E. Salech, F. | Age Ageing | 2020 |
delirium |
| Cholinesterase alterations in delirium after cardiosurgery: a German monocentric prospective study | Adam, E. H. Haas, V. Lindau, S. Zacharowski, K. Scheller, B. | BMJ Open | 2020 |
acetylcholinesterase |
| Cornell Assessment of Pediatric Delirium: a valid, rapid, observational tool for screening delirium in the PICU* | Traube, C. Silver, G. Kearney, J. Patel, A. Atkinson, T. M. Yoon, M. J. Halpert, S. Augenstein, J. Sickles, L. E. Li, C. Greenwald, B. | Crit Care Med | 2014 |
Adolescent |
| The Preschool Confusion Assessment Method for the ICU: Valid and Reliable Delirium Monitoring for Critically Ill Infants and Children | Smith, H. A. Gangopadhyay, M. Goben, C. M. Jacobowski, N. L. Chestnut, M. H. Savage, S. Rutherford, M. T. Denton, D. Thompson, J. L. Chandrasekhar, R. Acton, M. Newman, J. Noori, H. P. Terrell, M. K. Williams, S. R. Griffith, K. Cooper, T. J. Ely, E. W. F | Crit Care Med | 2016 |
Child, Preschool |
| Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit | Smith, H. A. Boyd, J. Fuchs, D. C. Melvin, K. Berry, P. Shintani, A. Eden, S. K. Terrell, M. K. Boswell, T. Wolfram, K. Sopfe, J. Barr, F. E. Pandharipande, P. P. Ely, E. W. | Crit Care Med | 2011 |
Child |
| Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale | Sikich, N. Lerman, J. | Anesthesiology | 2004 |
*Anesthesia Recovery Period |
| From Pediatrics to Geriatrics: Toward a Unified Standardized Screening Tool for Delirium: A Thought Experiment | Schieveld, J. N. van Zwieten, J. J. | Crit Care Med | 2016 |
Adult |
| Diagnostic considerations regarding pediatric delirium: a review and a proposal for an algorithm for pediatric intensive care units | Schieveld, J. N. van der Valk, J. A. Smeets, I. Berghmans, E. Wassenberg, R. Leroy, P. L. Vos, G. D. van Os, J. | Intensive Care Med | 2009 |
Age Factors |
| On the utility of diagnostic instruments for pediatric delirium in critical illness: an evaluation of the Pediatric Anesthesia Emergence Delirium Scale, the Delirium Rating Scale 88, and the Delirium Rating Scale-Revised R-98 | Janssen, N. J. Tan, E. Y. Staal, M. Janssen, E. P. Leroy, P. L. Lousberg, R. van Os, J. Schieveld, J. N. | Intensive Care Med | 2011 |
*Anesthesia Recovery Period |
| Validation of the SOS-PD scale for assessment of pediatric delirium: a multicenter study | Ista, E. van Beusekom, B. van Rosmalen, J. Kneyber, M. C. J. Lemson, J. Brouwers, A. Dieleman, G. C. Dierckx, B. de Hoog, M. Tibboel, D. van Dijk, M. | Crit Care | 2018 |
Adolescent |
| Sophia Observation withdrawal Symptoms-Paediatric Delirium scale: A tool for early screening of delirium in the PICU | Ista, E. Te Beest, H. van Rosmalen, J. de Hoog, M. Tibboel, D. van Beusekom, B. van Dijk, M. | Aust Crit Care | 2018 |
Adolescent |
| Psychometric evaluation of the Sophia Observation withdrawal symptoms scale in critically ill children | Ista, E. de Hoog, M. Tibboel, D. Duivenvoorden, H. J. van Dijk, M. | Pediatr Crit Care Med | 2013 |
Adolescent |
| Clinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals | Harris, J. Ramelet, A. S. van Dijk, M. Pokorna, P. Wielenga, J. Tume, L. Tibboel, D. Ista, E. | Intensive Care Med | 2016 |
Child |
| Assessment scales for delirium: A review | Grover, S. Kate, N. | World J Psychiatry | 2012 |
Cognition |
| Diagnostic accuracy of delirium diagnosis in pediatric intensive care: a systematic review | Daoud, A. Duff, J. P. Joffe, A. R. Alberta Sepsis, Network | Crit Care | 2014 |
Anesthesia/adverse effects |
| Diagnostic accuracy of delirium diagnosis in pediatric intensive care: a systematic review | Daoud, A. Duff, J. P. Joffe, A. R. Alberta Sepsis, Network | Crit Care | 2014 |
Anesthesia/adverse effects |
| Delirium is prevalent in older hospital inpatients and associated with adverse outcomes: Results of a prospective multi-centre study on World Delirium Awareness Day | Welch, C. McCluskey, L. Wilson, D. Chapman, G. E. Jackson, T. A. Treml, J. Davis, D. Cunningham, E. Copeland, C. Quinn, T. Pinkney, T. Mahida, R. Nightingale, P. Richardson, S. Todd, O. Willott, R. Torsney, K. Ni Lochlainn, M. Giridharan, K. Cox, N. Masol | BMC Medicine | 2019 |
adult |
| Olanzapine Versus Haloperidol for Treatment of Delirium in Patients with Advanced Cancer: A Phase III Randomized Clinical Trial | van der Vorst, Mjdl Neefjes, E. C. W. Boddaert, M. S. A. Verdegaal, Batt Beeker, A. Teunissen, S. C. C. Beekman, A. T. F. Wilschut, J. A. Berkhof, J. Zuurmond, W. W. A. Verheul, H. M. W. | Oncologist | 2019 |
Advanced cancer |
| Diverging Awareness of Postoperative Delirium and Cognitive Dysfunction in German Health Care Providers | Sturm, H. Wildermuth, R. Stolz, R. Bertram, L. Eschweiler, G. W. Thomas, C. Rapp, M. Joos, S. | Clin Interv Aging | 2019 |
Pocd |
| An evaluation of the Danish version of the Pediatric Anesthesia Emergence Delirium scale | Simonsen, B. Y. Skovby, P. Lisby, M. | Acta Anaesthesiol Scand | 2019 | |
| Incidence and Risk Factors for Delirium in Elderly Patients with Critical Limb Ischaemia | Roijers, J. P. Rakke, Y. S. Hopmans, C. J. Buimer, M. G. de Groot, H. G. W. Ho, G. H. Veen, E. J. Mulder, P. G. H. van der Laan, L. | Eur J Vasc Endovasc Surg | 2019 |
Critical limb ischaemia |
| Initiative for Prevention and Early Identification of Delirium in Medical-Surgical Units: Lessons Learned in the Past Five Years | Rohatgi, N. Weng, Y. Bentley, J. Lansberg, M. G. Shepard, J. Mazur, D. Ahuja, N. Hopkins, J. | Am J Med | 2019 |
Delirium |
| Elevation of Preoperative Ammonia Level Is Not Associated With the Incidence of Postoperative Delirium in Patients with Liver Transplantation: A Propensity Score Matching Analysis | Ri, H. S. Choi, Y. J. Park, J. Y. Jin, S. J. Lee, Y. S. Son, J. M. Yoon, S. Z. Shin, H. W. Choi, B. H. Lee, T. B. | Transplant Proc | 2019 | |
| Fluctuations of consciousness after stroke: Associations with the confusion assessment method for the intensive care unit (CAM-ICU) and potential undetected delirium | Reznik, M. E. Daiello, L. A. Thompson, B. B. Wendell, L. C. Mahta, A. Potter, N. S. Yaghi, S. Levy, M. M. Fehnel, C. R. Furie, K. L. Jones, R. N. | J Crit Care | 2019 |
Consciousness |
| Postoperative serum albumin decrease independently predicts delirium in elderly subjects after total joint arthroplasty | Qi, J. Liu, C. Chen, L. Chen, J. | Curr Pharm Des | 2019 |
Postoperative delirium |
| Dexmedetomidine versus propofol sedation in reducing delirium among older adults in the ICU: A systematic review and meta-analysis | Pereira, J. V. Sanjanwala, R. M. Mohammed, M. K. Le, M. L. Arora, R. C. | Eur J Anaesthesiol | 2019 | |
| Delirium Rates in Advanced Cancer Patients Admitted to Different Palliative Care Settings: Does It Make the Difference? | Pallotti, M. C. Lopez-Fidalgo Ph, D. J. Biasco, G. Celin, D. Centeno, C. Paragona, M. Moroni, M. Noguera, A. | J Palliat Med | 2019 |
cancer patients |
| Randomized Controlled Trial of Enhanced Recovery Program Dedicated to Elderly Patients after Colorectal Surgery | Ostermann, S. Morel, P. Chalé, J. J. Bucher, P. Konrad, B. Meier, R. P. H. Ris, F. Schiffer, E. R. C. | Diseases of the Colon and Rectum | 2019 |
NCT01646190 |
| The effect of ketamine on emergence agitation in children: A systematic review and meta-analysis | Ng, K. T. Sarode, D. Lai, Y. S. Teoh, W. Y. Wang, C. Y. | Paediatr Anaesth | 2019 |
emergence agitation |
| BIS index monitoring and perioperative neurocognitive disorders in older adults: a systematic review and meta-analysis | Miao, M. Xu, Y. Sun, M. Chang, E. Cong, X. Zhang, J. | Aging Clin Exp Res | 2019 |
Bispectral index |
| Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients | McNeil, J. B. Hughes, C. G. Girard, T. Ware, L. B. Ely, E. W. Chandrasekhar, R. Han, J. H. | PLoS One | 2019 | |
| Randomized controlled trial of acupuncture to prevent emergence delirium in children undergoing myringotomy tube placement | Martin, C. S. Yanez, N. D. Treggiari, M. M. Piper, L. Cusick, J. Lalwani, K. | Minerva Anestesiol | 2019 | |
| Detecting delirium in patients with acute stroke: a systematic review of test accuracy | Mansutti, I. Saiani, L. Palese, A. | BMC Neurol | 2019 |
Instruments |
| Associations of 4AT with mobility, length of stay and mortality in hospital and discharge destination among patients admitted with hip fractures | Lisk, R. Yeong, K. Enwere, P. Jenkinson, J. Robin, J. Irvin-Sellers, M. Fluck, D. Osmani, A. Sharmin, R. Sharma, P. Fry, C. H. Han, T. S. | Age Ageing | 2019 |
Nhs |
| Effectiveness of an advanced practice nurse-led delirium education and training programme | Lieow, J. L. M. Chen, F. S. M. Song, G. Tang, P. S. Kowitlawakul, Y. Mukhopadhyay, A. | Int Nurs Rev | 2019 |
Advanced Practice Nurses |
| Comparison of emergence agitation between succinylcholine and rocuronium-sugammadex in adults following closed reduction of a nasal bone fracture: A prospective randomized controlled trial | Lee, S. J. Sung, T. Y. Cho, C. K. | BMC Anesthesiology | 2019 |
adult |
| Risk factors for post-intensive care syndrome: A systematic review and meta-analysis | Lee, M. Kang, J. Jeong, Y. J. | Aust Crit Care | 2019 |
Intensive care units |
| Effect of Perioperative Low-Dose Dexmedetomidine on Postoperative Delirium After Living-Donor Liver Transplantation: A Randomized Controlled Trial | Lee, H. Yang, S. M. Chung, J. Oh, H. W. Yi, N. J. Suh, K. S. Oh, S. Y. Ryu, H. G. | Transplant Proc | 2019 | |
| The Association of Perioperative Serum Lactate Levels with Postoperative Delirium in Elderly Trauma Patients | Lee, C. Lee, J. Cho, H. Song, J. Jung, H. Ma, X. Hwang, J. | BioMed Research International | 2019 |
lactic acid |
| Frailty defined by 19 items as a predictor of short-term functional recovery in patients with hip fracture | Inoue, T. Misu, S. Tanaka, T. Kakehi, T. Kakiuchi, M. Chuman, Y. Ono, R. | Injury | 2019 |
aged |
| Using language descriptors to recognise delirium: a survey of clinicians and medical coders to identify delirium-suggestive words | Holmes, N. E. Amjad, S. Young, M. Berlowitz, D. J. Bellomo, R. | Crit Care Resusc | 2019 |
*Clinical Coding |
| Diagnostic test accuracy meta-analysis of PRE-DELIRIC (PREdiction of DELIRium in ICu patients): A delirium prediction model in intensive care practice | Ho, M. H. Chen, K. H. Montayre, J. Liu, M. F. Chang, C. C. Traynor, V. Shen Hsiao, S. T. Chang, H. R. Chiu, H. Y. | Intensive Crit Care Nurs | 2019 |
Delirium |
| Delirium management: Let's get physical? A systematic review and meta-analysis | Haley, M. N. Casey, P. Kane, R. Y. Darzins, P. Lawler, K. | Australas J Ageing | 2019 |
delirium |
| Delirium post-cardiac surgery: Incidence and associated factors | Habeeb-Allah, A. Alshraideh, J. A. | Nurs Crit Care | 2019 |
associated factors |
| EEG Correlates of Delirium in Children and Young Adults With CD19-Directed CAR T Cell Treatment-Related Neurotoxicity | Gust, J. Annesley, C. E. Gardner, R. A. Bozarth, X. | J Clin Neurophysiol | 2019 | |
| Process of implementing and delivering the Prevention of Delirium system of care: a mixed method preliminary study | Godfrey, M. Green, J. Smith, J. Cheater, F. Inouye, S. K. Hurst, K. Young, J. | BMC Geriatr | 2019 |
Delirium prevention |
| Association between postoperative delirium and postoperative cerebral oxygen desaturation in older patients after cardiac surgery | Eertmans, W. De Deyne, C. Genbrugge, C. Marcus, B. Bouneb, S. Beran, M. Fret, T. Gutermann, H. Boer, W. Vander Laenen, M. Heylen, R. Mesotten, D. Vanelderen, P. Jans, F. | Br J Anaesth | 2019 |
cardiac surgery |
| Frailty and hospital outcomes within a low socioeconomic population | Clark, S. Shaw, C. Padayachee, A. Howard, S. Hay, K. Frakking, T. T. | QJM | 2019 | |
| Perioperative outcomes in geriatric patients undergoing hip fracture surgery with different anesthesia techniques: A systematic review and meta-analysis | Chen, D. X. Yang, L. Ding, L. Li, S. Y. Qi, Y. N. Li, Q. | Medicine | 2019 |
Aged |
| Postoperative delirium is associated with increased plasma neurofilament light | Casey, C. P. Lindroth, H. Mohanty, R. Farahbakhsh, Z. Ballweg, T. Twadell, S. Miller, S. Krause, B. Prabhakaran, V. Blennow, K. Zetterberg, H. Sanders, R. D. | Brain | 2019 |
adult |
| Differential clinical characteristics, management and outcome of delirium among ward compared with intensive care unit patients | Canet, E. Amjad, S. Robbins, R. Lewis, J. Matalanis, M. Jones, D. Bellomo, R. | Intern Med J | 2019 |
*agitation |
| An Evaluation of Risperidone Dosing for Pediatric Delirium in Children Less Than or Equal to 2 Years of Age | Campbell, C. T. Grey, E. Munoz-Pareja, J. Manasco, K. B. | Annals of Pharmacotherapy | 2019 |
article |
| Inpatient Rehabilitation Delirium Screening: Impact on Acute Care Transfers and Functional Outcomes | Bushi, S. Barrett, A. M. Oh-Park, M. | PMR | 2019 |
Acute Care Transfer |
| Routine Management of Postoperative Delirium Outside the ICU: Results of an International Survey among Anaesthesiologists | Bilotta, F. Weiss, B. Neuner, B. Kramer, S. Aldecoa, C. Bettelli, G. Sanders, R. D. Delp, S. M. Spies, C. D. | Acta Anaesthesiol Scand | 2019 |
Postoperative delirium |
| Impact of delirium on short-term outcomes in hip fracture patients under a program of approach to delirium | Bielza, R. Zambrana, F. Fernandez de la Puente, E. Sanjurjo, J. Andreu, C. Thuissard, I. J. Gomez Cerezo, J. | Geriatr Gerontol Int | 2019 |
delirium |
| Outcome Differences by Delirium Motor Subtype in Patients with Ischemic Stroke | Yang, H. W. Lee, M. Shin, J. W. Jeong, H. S. Kim, J. Kim, J. L. | Psychiatry Investig | 2019 |
Delirium |
| Serial Ottawa 3DY assessments to detect delirium in older emergency department community dwellers | Yadav, K. Boucher, V. Carmichael, P. H. Voyer, P. Eagles, D. Pelletier, M. Gouin, E. Daoust, R. Vu, T. T. M. Berthelot, S. Emond, M. | Age Ageing | 2019 |
delirium |