What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients (Review)
- Authors
- Burton JK, Craig LE, Yong SQ, Siddiqi N, Teale EA, Woodhouse R, Barugh AJ, Shepherd AM, Brunton A, Freeman SC, Sutton AJ, Quinn TJ
- Year
- 2021
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is an acute neuropsychological disorder that is common in hospitalised patients. It can be distressing to patients and carers and it is associated with serious adverse outcomes. Treatment options for established delirium are limited and so prevention of delirium is desirable. Non-pharmacological interventions are thought to be important in delirium prevention. OBJECTIVES: To assess the effectiveness of non-pharmacological interventions designed to prevent delirium in hospitalised patients outside intensive care units (ICU).
Search methods: We searched ALOIS, the specialised register of the Cochrane Dementia and Cognitive Improvement Group, with additional searches conducted in MEDLINE, Embase, PsycINFO, CINAHL, LILACS, Web of Science Core Collection, ClinicalTrials.gov and the World Health Organization Portal/ICTRP to 16 September 2020. There were no language or date restrictions applied to the electronic searches, and no methodological filters were used to restrict the search.
Selection criteria: We included randomised controlled trials (RCTs) of single and multicomponent non-pharmacological interventions for preventing delirium in hospitalised adults cared for outside intensive care or high dependency settings. We only included non-pharmacological interventions which were designed and implemented to prevent delirium. DATA COLLECTION AND ANALYSIS: Two review authors independently examined titles and abstracts identified by the search for eligibility and extracted data from full-text articles. Any disagreements on eligibility and inclusion were resolved by consensus. We used standard Cochrane methodological procedures. The primary outcomes were: incidence of delirium; inpatient and later mortality; and new diagnosis of dementia. We included secondary and adverse outcomes as pre-specified in the review protocol. We used risk ratios (RRs) as measures of treatment effect for dichotomous outcomes and between-group mean differences for continuous outcomes. The certainty of the evidence was assessed using GRADE. A complementary exploratory analysis was undertaker using a Bayesian component network meta-analysis fixed-effect model to evaluate the comparative effectiveness of the individual components of multicomponent interventions and describe which components were most strongly associated with reducing the incidence of delirium.
Main results: We included 22 RCTs that recruited a total of 5718 adult participants. Fourteen trials compared a multicomponent delirium prevention intervention with usual care. Two trials compared liberal and restrictive blood transfusion thresholds. The remaining six trials each investigated a different non-pharmacological intervention. Incidence of delirium was reported in all studies. Using the Cochrane risk of bias tool, we identified risks of bias in all included trials. All were at high risk of performance bias as participants and personnel were not blinded to the interventions. Nine trials were at high risk of detection bias due to lack of blinding of outcome assessors and three more were at unclear risk in this domain. Pooled data showed that multi-component non-pharmacological interventions probably reduce the incidence of delirium compared to usual care (10.5% incidence in the intervention group, compared to 18.4% in the control group, risk ratio (RR) 0.57, 95% confidence interval (CI) 0.46 to 0.71, I2 = 39%; 14 studies; 3693 participants; moderate-certainty evidence, downgraded due to risk of bias). There may be little or no effect of multicomponent interventions on inpatient mortality compared to usual care (5.2% in the intervention group, compared to 4.5% in the control group, RR 1.17, 95% CI 0.79 to 1.74, I2 = 15%; 10 studies; 2640 participants; low-certainty evidence downgraded due to inconsistency and imprecision). No studies of multicomponent interventions reported data on new diagnoses of dementia. Multicomponent interventions may result in a small reduction of around a day in the duration of a delirium episode (mean difference (MD) -0.93, 95% CI -2.01 to 0.14 days, I2 = 65%; 351 participants; low-certainty evidence downgraded due to risk of bias and imprecision). The evidence is very uncertain about the effect of multicomponent interventions on delirium severity (standardised mean difference (SMD) -0.49, 95% CI -1.13 to 0.14, I2=64%; 147 participants; very low-certainty evidence downgraded due to risk of bias and serious imprecision). Multicomponent interventions may result in a reduction in hospital length of stay compared to usual care (MD -1.30 days, 95% CI -2.56 to -0.04 days, I2=91%; 3351 participants; low-certainty evidence downgraded due to risk of bias and inconsistency), but little to no difference in new care home admission at the time of hospital discharge (RR 0.77, 95% CI 0.55 to 1.07; 536 participants; low-certainty evidence downgraded due to risk of bias and imprecision). Reporting of other adverse outcomes was limited. Our exploratory component network meta-analysis found that re-orientation (including use of familiar objects), cognitive stimulation and sleep hygiene were associated with reduced risk of incident delirium. Attention to nutrition and hydration, oxygenation, medication review, assessment of mood and bowel and bladder care were probably associated with a reduction in incident delirium but estimates included the possibility of no benefit or harm. Reducing sensory deprivation, identification of infection, mobilisation and pain control all had summary estimates that suggested potential increases in delirium incidence, but the uncertainty in the estimates was substantial. Evidence from two trials suggests that use of a liberal transfusion threshold over a restrictive transfusion threshold probably results in little to no difference in incident delirium (RR 0.92, 95% CI 0.62 to 1.36; I2 = 9%; 294 participants; moderate-certainty evidence downgraded due to risk of bias). Six other interventions were examined, but evidence for each was limited to single studies and we identified no evidence of delirium prevention. AUTHORS’ CONCLUSIONS: There is moderate-certainty evidence regarding the benefit of multicomponent non-pharmacological interventions for the prevention of delirium in hospitalised adults, estimated to reduce incidence by 43% compared to usual care. We found no evidence of an effect on mortality. There is emerging evidence that these interventions may reduce hospital length of stay, with a trend towards reduced delirium duration, although the effect on delirium severity remains uncertain. Further research should focus on implementation and detailed analysis of the components of the interventions to support more effective, tailored practice recommendations.
- PMID
- Keywords
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Comparison of the prevalence and associated factors of hyperactive delirium in advanced cancer patients between inpatient palliative care and palliative home care | Hamano, J. Mori, M. Ozawa, T. Sasaki, J. Kawahara, M. Nakamura, A. Hashimoto, K. Hisajima, K. Koga, T. Goto, K. Fukumoto, K. Morimoto, Y. Goshima, M. Sekimoto, G. Baba, M. Oya, K. Matsunuma, R. Azuma, Y. Imai, K. Morita, T. Shinjo, T. | Cancer Med | 2020 |
advanced cancer patients |
| Treatment of delirium in palliative patients - role of neuroleptics | Hainsch-Müller, I. Aulmann, C. Djukic, I. | Internistische Praxis | 2020 |
neuroleptic agent |
| Identifying Delirium Early after Stroke: A New Prediction Tool for the Intensive Care Unit | Haight, T. N. Marsh, E. B. | J Stroke Cerebrovasc Dis | 2020 |
Adult |
| Socioeconomic Factors and Intensive Care Unit-Related Cognitive Impairment | Haddad, D. N. Mart, M. F. Wang, L. Lindsell, C. J. Raman, R. Nordness, M. F. Sharp, K. W. Pandharipande, P. P. Girard, T. D. Ely, E. W. Patel, M. B. | Ann Surg | 2020 |
Aged |
| Opioid use is Associated with ICU Delirium in Mechanically Ventilated Children | Gupta, N. Woolley, A. Talathi, S. Davlyatov, G. Colston, C. Hayes, L. | J Crit Care Med (Targu Mures) | 2020 |
intensive care unit |
| A two-year multicenter point prevalence study of older patients with hip fractures admitted to rehabilitation units in Italy | Guerzoni, V. Lanzoni, A. Pozzi, C. Paci, M. Gatti, R. Benedetti, M. G. Gentile, S. Trabucchi, M. Bellelli, G. Morandi, A. | Eur Geriatr Med | 2020 |
Delirium |
| Preoperative Cognitive Impairment and Postoperative Delirium Predict Decline in Activities of Daily Living after Cardiac Surgery-A Prospective, Observational Cohort Study | Guenther, U. Hoffmann, F. Dewald, O. Malek, R. Brimmers, K. Theuerkauf, N. Putensen, C. Popp, J. | Geriatrics (Basel) | 2020 |
activity of daily living |
| Risk Factors for Delirium and Cognitive Decline Following Coronary Artery Bypass Grafting Surgery: A Systematic Review and Meta-Analysis | Greaves, D. Psaltis, P. J. Davis, D. H. J. Ross, T. J. Ghezzi, E. S. Lampit, A. Smith, A. E. Keage, H. A. D. | J Am Heart Assoc | 2020 |
cognitive decline |
| Prevalence and risk factors of delirium in the intensive care unit: An observational study | Gravante, F. Giannarelli, D. Pucci, A. Gagliardi, A. M. Mitello, L. Montagna, A. Latina, R. | Nurs Crit Care | 2020 |
delirium |
| Health Care Professionals' Reports of Cancer Pain Cues Among Older People With Delirium: A Qualitative-Quantitative Content Analysis | Graham, C. A. Chaves, G. Harrison, R. Gauthier, L. R. Nissim, R. Zimmermann, C. Chan, V. Rodin, G. Stevens, B. Gagliese, L. | J Pain Symptom Manage | 2020 |
Cancer pain |
| Benzodiazepinics and the treatment of delirium: a literature review | Gonçalves, O. H. P. Pellissari, G. M. Paiva, H. S. | Rev Assoc Med Bras (1992) | 2020 |
Benzodiazepines/therapeutic use |
| Analysis of Delirium from the Dynamic Symptoms Model: A Literature Review | Gómez Tovar, L. O. Henao Castaño, A. M. | Critical Care Nursing Quarterly | 2020 |
conceptual framework |
| Association of delirium with long-term cognitive decline: A meta-analysis | Goldberg, T. E. Chen, C. Wang, Y. Jung, E. Swanson, A. Ing, C. Garcia, P. S. Whittington, R. A. Moitra, V. | JAMA Neurology | 2020 |
article |
| Functional and cognitive decline in older delirious adults after an emergency department visit | Giroux, M. Émond, M. Nadeau, A. Boucher, V. Carmichael, P. H. Voyer, P. Pelletier, M. Gouin, É Daoust, R. Berthelot, S. Lamontagne, M. E. Morin, M. Lemire, S. Sirois, M. J. | Age Ageing | 2020 |
cognitive decline |
| The prevalence rates and sequelae of delirium at age older than 90 years | Gehrke, S. Bode, L. Seiler, A. Ernst, J. von Känel, R. Boettger, S. | Palliat Support Care | 2020 |
Delirium |
| Complications of LVAD utilization in older adults | Gazda, A. J. Kwak, M. J. Akkanti, B. Nathan, S. Kumar, S. de Armas, I. S. Baer, P. Patel, B. Kar, B. Gregoric, I. D. | Heart and Lung | 2020 |
aged |
| Consolidated framework for advancing implementation science for the implementation process and adherence assessment of a non-pharmacological delirium prevention program | Garrido, M. A. Alvarez, E. A. Ponce, D. P. Salech, F. Tobar, D. I. Tobar, E. A. | Int J Geriatr Psychiatry | 2020 |
Cfir |
| Delirium and Adverse Outcomes in Hospitalized Patients with COVID-19 | Garcez, F. B. Aliberti, M. J. R. Poco, P. C. E. Hiratsuka, M. Takahashi, S. D. F. Coelho, V. A. Salotto, D. B. Moreira, M. L. V. Jacob-Filho, W. Avelino-Silva, T. J. | Journal of the American Geriatrics Society | 2020 |
mechanical ventilator |
| The Effects of Melatonin Supplementation on Sleep Quality and Assessment of the Serum Melatonin in ICU Patients: A Randomized Controlled Trial | Gandolfi, J. V. Di Bernardo, A. P. A. Chanes, D. A. V. Martin, D. F. Joles, V. B. Amendola, C. P. Sanches, L. C. Ciorlia, G. L. Lobo, S. M. | Critical care medicine | 2020 |
adult |
| Atypical presentation of COVID-19 in hospitalised older adults | Gan, J. M. Kho, J. Akhunbay-Fudge, M. Choo, H. M. Wright, M. Batt, F. Mandal, A. K. J. Chauhan, R. Missouris, C. G. | Ir J Med Sci | 2020 |
Atypical symptoms |
| Delirium in elderly patients: Prospective prevalence across hospital services | Fuchs, S. Bode, L. Ernst, J. Marquetand, J. von Känel, R. Böttger, S. | Gen Hosp Psychiatry | 2020 |
>65 years |
| Ascertainment of delirium status using natural language processing from electronic health records | Fu, S. Lopes, G. S. Pagali, S. R. Thorsteinsdottir, B. LeBrasseur, N. K. Wen, A. Liu, H. Rocca, W. A. Olson, J. E. St Sauver, J. Sohn, S. | J Gerontol A Biol Sci Med Sci | 2020 |
confusion assessment method |
| A Multi-Phase Quality Improvement Initiative for the Treatment of Active Delirium in Older Persons | Friedman, J. I. Li, L. Kirpalani, S. Zhong, X. Freeman, R. Cheng, Y. T. Alfonso, F. L. McAlpine, G. Vakil, A. Macon, B. Francaviglia, P. Cassara, M. LoPachin, V. Reina, K. Davis, K. Reich, D. Craven, C. K. Mazumdar, M. Siu, A. L. | J Am Geriatr Soc | 2020 |
Confusion Assessment Method |
| Delirium diagnostic tool-provisional (DDT-Pro) scores in delirium, subsyndromal delirium and no delirium | Franco, J. G. Trzepacz, P. T. Sepúlveda, E. Ocampo, M. V. Velásquez-Tirado, J. D. Zaraza, D. R. Restrepo, C. Giraldo, A. M. Serna, P. A. Zuluaga, A. López, C. | Gen Hosp Psychiatry | 2020 |
Cluster analysis |
| A multimodal sevoflurane-based sedation regimen in combination with targeted temperature management in post-cardiac arrest patients reduces the incidence of delirium: An observational propensity score-matched study | Foudraine, N. A. Algargoush, A. van Osch, F. H. Bos, A. T. | Resuscitation | 2020 |
Cardiac arrest |
| Association of Plasma Neurofilament Light with Postoperative Delirium | Fong, T. G. Vasunilashorn, S. M. Ngo, L. Libermann, T. A. Dillon, S. T. Schmitt, E. M. Pascual-Leone, A. Arnold, S. E. Jones, R. N. Marcantonio, E. R. Inouye, S. K. | Ann Neurol | 2020 |
Aged |
| Course and Recognition of Poststroke Delirium: A Prospective Noninferiority Trial of Delirium Screening Tools | Fleischmann, R. Warwas, S. Andrasch, T. Kunz, R. Witt, C. Mengel, A. von Sarnowski, B. | Stroke | 2020 |
delirium |
| The collateral history: an overlooked core clinical skill | Fitzpatrick, D. Doyle, K. Finn, G. Gallagher, P. | Eur Geriatr Med | 2020 |
Clinical training |
| Management of delirium superimposed on dementia in a dementia service | FitzGerald, J. Yan, M. Bandecar, A. Ratnasabapathy, V. Rubinsztein, J. Hatfield, C. Ruhi, S. | Progress in Neurology and Psychiatry | 2020 |
adult |
| Partnering With Family Members to Detect Delirium in Critically Ill Patients | Fiest, K. M. Krewulak, K. D. Ely, E. W. Davidson, J. E. Ismail, Z. Sept, B. G. Stelfox, H. T. | Crit Care Med | 2020 |
adult |
| The correlation of intraoperative hypotension and postoperative cognitive impairment: a meta-analysis of randomized controlled trials | Feng, X. Hu, J. Hua, F. Zhang, J. Zhang, L. Xu, G. | BMC Anesthesiol | 2020 |
Intraoperative hypotension |
| The effect of joints range of motion exercises on delirium prevention in patients admitted to intensive care units | Farzammanesh, A. Jahani, S. Rashidi, M. Maraghi, E. Ravanbakhsh, M. | International Journal of Pharmaceutical and Phytopharmacological Research | 2020 |
IRCT20180114038362N1 |
| Sleep and Delirium in Older Adults | Farasat, S. Dorsch, J. J. Pearce, A. K. Moore, A. A. Martin, J. L. Malhotra, A. Kamdar, B. B. | Curr Sleep Med Rep | 2020 |
Acetylcholine |
| Association between use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and postoperative delirium | Farag, E. Farag, E. Liang, C. Liang, C. Mascha, E. J. Mascha, E. J. Argalious, M. Y. Ezell, J. Maheshwari, K. Esa, W. A. S. Troianos, C. A. Sessler, D. I. | Anesthesiology | 2020 |
adult |
| Delirium in cardiology: An old problem, a new emergency | Falsini, G. Romanelli, S. Insana, L. Frongillo, D. Grotti, S. Angioli, P. Ducci, K. Liistro, F. Calchetti, B. Rossi, R. Bolognese, L. | Giornale Italiano di Cardiologia | 2020 |
attitude to illness |
| Surveying work-as-done in post-operative delirium risk factors collection and diagnosis monitoring | Falegnami, A. Patriarca, R. Costantino, F. Di Gravio, G. Bilotta, F. | Appl Ergon | 2020 |
RiskSOAP |
| Psychiatric disorders, delirium and mortality in patients referred for consultation in a burn center: A four-year retrospective study | Erdoğan, E. Delibaş, D. H. | Medical Journal of Bakirkoy | 2020 |
antidepressant agent |
| Delirium in Older People with COVID-19: Clinical Scenario and Literature Review | Emmerton, D. Abdelhafiz, A. | SN Compr Clin Med | 2020 |
Covid-19 |
| "It should not be that difficult to manage a condition that is so frequent": A qualitative study on hospital nurses' experience of delirium guidelines | Emme, C. | J Clin Nurs | 2020 |
Adult |
| Where should patients with or at risk of delirium be treated in an acute care system? Comparing the rates of delirium in patients receiving usual care versus alternative care: a systematic review and meta-analysis | Ekeozor, C. U. Jeyaruban, D. Lasserson, D. | Int J Clin Pract | 2020 |
Acute care |
| Effect of General Versus Spinal Anesthesia on Postoperative Delirium and Early Cognitive Dysfunction in Elderly Patients | Ehsani, R. Djalali Motlagh, S. Zaman, B. Sehat Kashani, S. Ghodraty, M. R. | Anesth Pain Med | 2020 |
Delirium |
| Anticholinergic Drug Burden and Delirium: A Systematic Review | Egberts, A. Moreno-Gonzalez, R. Alan, H. Ziere, G. Mattace-Raso, F. U. S. | Journal of the American Medical Directors Association | 2020 |
adult |
| Antipsychotics and Lorazepam During Delirium: Are We Harming Older Patients? A Real-Life Data Study | Egberts, A. Alan, H. Ziere, G. Mattace-Raso, F. U. S. | Drugs and Aging | 2020 |
acutely ill patient |
| Delirium in Internal Medicine Departments in a Tertiary Hospital in Israel: Occurrence, Detection Rates, Risk Factors, and Outcomes | Efraim, N. T. Zikrin, E. Shacham, D. Katz, D. Makulin, E. Barski, L. Zeller, L. Bartal, C. Freud, T. Lebedinski, S. Press, Y. | Front Med (Lausanne) | 2020 |
delirium |
| Development and validation of an aetiology in delirium diagnostic support tool | Eeles, E. Huang, L. Dakin, L. Ling, C. Dunn, E. Fraser, J. Dissanayaka, N. N. | Age Ageing | 2020 |
aetiology |
| Association of Geriatric Events With Perioperative Outcomes After Elective Inpatient Surgery | Dworsky, J. Q. Shellito, A. D. Childers, C. P. Copeland, T. P. Maggard-Gibbons, M. Tan, H. J. Saliba, D. Russell, M. M. | J Surg Res | 2020 |
Elderly |
| Is there an association between subjective sleep quality and daily delirium occurrence in critically ill adults? A post hoc analysis of a randomised controlled trial | Duprey, M. S. Devlin, J. W. Skrobik, Y. | BMJ Open Respir Res | 2020 |
clinical epidemiology |
| Approaches to Optimize Medication Data Analysis in Clinical Cohort Studies | Duprey, M. S. Devlin, J. W. Briesacher, B. A. Travison, T. G. Griffith, J. L. Inouye, S. K. | J Am Geriatr Soc | 2020 |
delirium |
| Delirium definition influences prediction of functional survival in patients one-year postcardiac surgery | Dubiel, C. Hiebert, B. M. Stammers, A. N. Sanjanwala, R. M. Tangri, N. Singal, R. K. Manji, R. A. Rudolph, J. L. Arora, R. C. | J Thorac Cardiovasc Surg | 2020 |
cardiac surgery |
| Prevalence and outcome of delirium among acute general medical inpatients in Cape Town, South Africa | Du Plooy, N. Day, C. Manning, K. Abdullah, F. James, K. Grace, L. Vorajee, N. April, C. Peter, J. Peter, J. Raubenheimer, P. J. | South African Medical Journal | 2020 |
indwelling urinary catheter |
| Delirium Post-Stroke-Influence on Post-Stroke Dementia (Research Study-Part of the PROPOLIS Study) | Droś, J. Kowalska, K. Pasińska, P. Szyper-Maciejowska, A. Gorzkowska, A. Klimkowicz-Mrowiec, A. | J Clin Med | 2020 |
cognitive impairment |
| Providing Evidence-Based Care, Day and Night: A Quality Improvement Initiative to Improve Intensive Care Unit Patient Sleep Quality | Douglas, S. L. Hobbs, H. A. Sibley, S. R. Digby, G. C. | J Intensive Care Med | 2020 |
critical care |
| An Implementation-Effectiveness Study of a Perioperative Delirium Prevention Initiative for Older Adults | Donovan, A. L. Braehler, M. R. Robinowitz, D. L. Lazar, A. A. Finlayson, E. Rogers, S. Douglas, V. C. Whitlock, E. L. | Anesth Analg | 2020 |
Aged |
| Effectiveness of a multidisciplinary comprehensive intervention model based on the Hospital Elderly Life Program to prevent delirium in patients with severe acute pancreatitis | Dong, Z. Song, J. Ge, M. Lin, C. Zhang, J. Chen, J. Wu, Y. | Ann Palliat Med | 2020 |
Pancreatitis |
| Does Preoperative Comprehensive Geriatric Assessment and Frailty Predict Postoperative Complications? | Dogrul, R. T. Dogrul, A. B. Konan, A. Caglar, O. Sumer, F. Caliskan, H. Kizilarslanoglu, M. C. Kilic, M. K. Balci, C. Arik, G. Aycicek, G. S. Ozsurekci, C. Halil, M. Cankurtaran, M. Yavuz, B. B. | World journal of surgery | 2020 |
aged |
| Preoperative Acute Pain Is Associated with Postoperative Delirium | Ding, X. Gao, X. Chen, Q. Jiang, X. Li, Y. Xu, J. Qin, G. Lu, S. Huang, D. | Pain Med | 2020 |
C-Reactive Protein |
| Effects of electroencephalography and regional cerebral oxygen saturation monitoring on perioperative neurocognitive disorders: a systematic review and meta-analysis | Ding, L. Chen, D. X. Li, Q. | BMC Anesthesiol | 2020 |
Electroencephalography |
| The Addition of Intravenous Propofol and Ketorolac to a Sevoflurane Anesthetic Lessens Emergence Agitation in Children Having Bilateral Myringotomy with Tympanostomy Tube Insertion: A Prospective Observational Study | d'Eon, B. Hackmann, T. Wright, A. S. | Children (Basel) | 2020 |
emergence agitation |
| Preoperative Nutritional Status and Risk for Subsyndromal Delirium in Older Adults Following Joint Replacement Surgery | Denny, D. L. Trotter, T. Lindseth, G. | Orthopedic nursing | 2020 |
aged |
| Non-pharmacological interventions to reduce the incidence and duration of delirium in critically ill patients: A systematic review and network meta-analysis | Deng, L. X. Cao, L. Zhang, L. N. Peng, X. B. Zhang, L. | J Crit Care | 2020 |
Delirium prevention |
| Multidimensional nursing interventions effect on delirium and hospital admission duration | Dehghani, S. Asadizaker, M. Adineh, M. Maraghi, E. Akbarian, S. Ramezani, B. | International Journal of Pharmaceutical and Phytopharmacological Research | 2020 |
IRCT20181005041233N1 |
| Effects of pain, sedation and delirium monitoring on clinical and economic outcome: A retrospective study | Deffland, M. Spies, C. Weiss, B. Keller, N. Jenny, M. Kruppa, J. Balzer, F. | PLoS ONE | 2020 |
NCT02265263 |
| The association of post-operative delirium with health-related quality of life and mortality after lung transplantation | DeBolt, C. Gao, Y. Sutter, N. Soong, A. Trinh, B. N. Kukreja, J. Kleinhenz, M. Venado, A. Leard, L. E. Hays, S. Greenland, J. R. Shah, R. J. Douglas, V. Kolaitis, N. A. Diamond, J. M. Smith, P. J. Singer, J. P. | American Journal of Respiratory and Critical Care Medicine | 2020 |
adult |
| Development and validation of a delirium risk prediction preoperative model for cardiac surgery patients (DELIPRECAS): An observational multicentre study | de la Varga-Martínez, O. Gómez-Pesquera, E. Muñoz-Moreno, M. F. Marcos-Vidal, J. M. López-Gómez, A. Rodenas-Gómez, F. Ramasco, F. Álvarez-Refojo, F. Tamayo, E. Gómez-Sánchez, E. | J Clin Anesth | 2020 |
Cardiac surgery |
| The Effect of Multiple Assessments on Delirium Detection: a Pilot Study | de Freitas, S. A. Wong, E. Lee, J. Y. Reppas-Rindlisbacher, C. Gabor, C. Curkovic, A. Patterson, C. J. | Can Geriatr J | 2020 |
3d-cam |
| Delirium Detection Based on the Clinical Experience of Pediatric Intensivists | de Castro, R. E. V. de Magalhães-Barbosa, M. C. Cunha, Ajlad Cheniaux, E. Prata-Barbosa, A. | Pediatr Crit Care Med | 2020 | |
| Kidney Function Modifies the Effect of Intraoperative Opioid Dosage on Postoperative Delirium | Davani, A. B. Snyder, S. H. Oh, E. S. Mears, S. C. Crews, D. C. Wang, N. Y. Sieber, F. E. | J Am Geriatr Soc | 2020 |
analgesics, opioids |
| One-year mortality rate after fragility hip fractures and associated risk in Nan, Thailand | Daraphongsataporn, N. Saloa, S. Sriruanthong, K. Philawuth, N. Waiwattana, K. Chonyuen, P. Pimolbutr, K. Sucharitpongpan, W. | Osteoporosis and Sarcopenia | 2020 |
aged |
| Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related? | Daou, M. Telias, I. Younes, M. Brochard, L. Wilcox, M. E. | Front Neurol | 2020 |
ICU acquired delirium |
| Delirium prevention and treatment in the emergency department (ED): a systematic review protocol | Dahlstrom, E. B. Han, J. H. Healy, H. Kennedy, M. Arendts, G. Lee, J. Carpenter, C. Lee, S. | BMJ Open | 2020 |
accident & emergency medicine |
| Pathomechanisms of Non-Traumatic Acute Brain Injury in Critically Ill Patients | Dabrowski, W. Siwicka-Gieroba, D. Gasinska-Blotniak, M. Zaid, S. Jezierska, M. Pakulski, C. Williams Roberson, S. Wesley Ely, E. Kotfis, K. | Medicina (Kaunas) | 2020 |
critical illness |
| Low molecular weight heparin in COVID-19 patients prevents delirium and shortens hospitalization | D’Ardes, D. Carrarini, C. Russo, M. Dono, F. Speranza, R. Digiovanni, A. Martinotti, G. Di Iorio, A. Onofrj, M. Cipollone, F. Bonanni, L. | Neurological Sciences | 2020 |
adult |
| Postoperative delirium: why, what, and how to confront it at your institution | Curtis, M. S. Forman, N. A. Donovan, A. L. Whitlock, E. L. | Curr Opin Anaesthesiol | 2020 |
Aged |
| Delirium due to intoxication with quetiapine: A systematic literature review | Crombez, S. van Den Wijngaert, V. Demyttenaere, K. de Fruyt, J. | Tijdschrift voor Psychiatrie | 2020 |
physostigmine |
| Postoperative delirium in patients with head and neck oral cancer in the West of Scotland | Crawford, J. E. Zubair, F. Baniulyte, G. Wales, C. J. Ansell, M. Thomson, E. Hislop, S. MacIver, C. Devine, J. McCaul, J. Young, D. McMahon, J. | Br J Oral Maxillofac Surg | 2020 |
Eras |
| Diagnosis, prevention, and management of delirium in the intensive cardiac care unit | Cortés-Beringola, A. Vicent, L. Martín-Asenjo, R. Puerto, E. Domínguez-Pérez, L. Maruri, R. Moreno, G. Vidán, M. T. Fernando, Arribas Bueno, H. | Am Heart J | 2020 | |
| Serum DBI and biomarkers of neuroinflammation in Alzheimer's disease and delirium | Conti, E. Andreoni, S. Tomaselli, D. Storti, B. Brovelli, F. Acampora, R. Da Re, F. Appollonio, I. Ferrarese, C. Tremolizzo, L. | Neurol Sci | 2020 |
Alzheimer’s disease |
| A complication of coronavirus disease 2019: delirium | Cipriani, G. Danti, S. Nuti, A. Carlesi, C. Lucetti, C. Di Fiorino, M. | Acta Neurol Belg | 2020 |
Betacoronavirus |
| Post-operative delirium and cognitive decline in kidney transplantation | Chu, N. M. Chen, X. Segev, D. L. McAdams-DeMarco, M. | Journal of the American Society of Nephrology | 2020 |
adult |
| Vitamin D and Delirium in Older Adults: A Case-Control Study in Geriatric Acute Care Unit | Chouët, J. Sacco, G. Karras, S. N. Llewellyn, D. J. Sánchez-Rodríguez, D. Annweiler, C. | Front Neurol | 2020 |
cognition |
| Risk factors for postoperative delirium in elderly patients after spinal fusion surgery | Choi, S. Jung, I. Yoo, B. Lee, S. Kim, M. C. | Anesth Pain Med (Seoul) | 2020 |
Aged |
| Multimodal Education Program to Improve Nurses' Knowledge and Confidence on Delirium Recognition in a Surgical-Trauma Intermediate-Care Setting | Choi, M. DeGennaro, R. Blevins, C. | Journal of doctoral nursing practice | 2020 |
adult |
| Development and validation of delirium prediction model for critically ill adults parameterized to ICU admission acuity | Cherak, S. J. Soo, A. Brown, K. N. Ely, E. W. Stelfox, H. T. Fiest, K. M. | PLoS One | 2020 |
Apache |
| Association of Glucose Variability and ICU Delirium of Patients after Liver Transplantation | Cheng, J. L. Dong, M. L. Zhang, Z. W. Liao, X. L. Yang, J. Y. Kang, Y. | Journal of Sichuan University. Medical science edition | 2020 |
adverse event |
| Modified Frailty Index Independently Predicts Postoperative Delirium and Delayed Neurocognitive Recovery After Elective Total Joint Arthroplasty | Chen, Y. Qin, J. | J Arthroplasty | 2020 |
delayed neurocognitive recovery |
| Risk predictive models for delirium in the intensive care unit: a systematic review and meta-analysis | Chen, X. Lao, Y. Zhang, Y. Qiao, L. Zhuang, Y. | Ann Palliat Med | 2020 |
Delirium |
| Diagnostic accuracy of the CAM-ICU and ICDSC in detecting intensive care unit delirium: A bivariate meta-analysis | Chen, T. J. Chung, Y. W. Chang, H. C. R. Chen, P. Y. Wu, C. R. Hsieh, S. H. Chiu, H. Y. | International journal of nursing studies | 2020 |
adult |
| Atypical Sleep and Postoperative Delirium in the Cardiothoracic Surgical Intensive Care Unit: A Pilot Prospective Study | Chen, Q. Peng, Y. Lin, Y. Li, S. Huang, X. Chen, L. W. | Nat Sci Sleep | 2020 |
atypical sleep |
| Delirium risk prediction models for intensive care unit patients: A systematic review | Chen, J. Yu, J. Zhang, A. | Intensive Crit Care Nurs | 2020 |
Delirium |
| The role of statins in the management of delirium: Recent advances | Chen, J. Wang, Y. Hu, X. Li, M. Xiong, K. Zhang, Z. Chen, Q. | CNS Neurol Disord Drug Targets | 2020 |
Delirium |
| Analysis of Risk Factors for Postoperative Delirium After Liver Transplantation | Chen, J. Wang, H. He, Z. Li, T. | Neuropsychiatr Dis Treat | 2020 |
ammonia |
| Analgesia and sedation in patients with ARDS | Chanques, G. Constantin, J. M. Devlin, J. W. Ely, E. W. Fraser, G. L. Gélinas, C. Girard, T. D. Guérin, C. Jabaudon, M. Jaber, S. Mehta, S. Langer, T. Murray, M. J. Pandharipande, P. Patel, B. Payen, J. F. Puntillo, K. Rochwerg, B. Shehabi, Y. Strøm, T | Intensive Care Med | 2020 |
Analgesia/methods/ standards |
| Delirium Prevention, Detection, and Treatment in Emergency Medicine Settings: A Geriatric Emergency Care Applied Research (GEAR) Network Scoping Review and Consensus Statement | Carpenter, C. R. Hammouda, N. Linton, E. A. Doering, M. Ohuabunwa, U. K. Ko, K. J. Hung, W. W. Shah, M. N. Lindquist, L. A. Biese, K. Wei, D. Hoy, L. Nerbonne, L. Hwang, U. Dresden, S. M. | Academic Emergency Medicine | 2020 |
aged |
| Geriatric emergency care applied research network cognitive impairment priorities consensus conference | Carpenter, C. R. Hammouda, N. Linton, E. Doerring, M. Ohuabunwa, U. Ko, K. Hung, W. Dresden, S. M. Shah, M. N. Lindquist, L. Biese, K. Wei, D. Hwang, U. | Academic Emergency Medicine | 2020 |
adult |
| Identifying and Responding to Delirium in Acute Stroke: Clinical Team Members' Understandings | Carin-Levy, G. Nicol, K. van Wijck, F. Mead, G. McVittie, C. | Qualitative health research | 2020 |
adult |
| Antipsychotic use in the prevention and treatment of intensive care unit delirium in pediatric patients | Capino, A. C. Thomas, A. N. Baylor, S. Hughes, K. M. Miller, J. L. Johnson, P. N. | Journal of Pediatric Pharmacology and Therapeutics | 2020 |
haloperidol |
| Screening instruments for cognitive impairment in older patients in the Emergency Department: a systematic review and meta-analysis | Calf, A. H. Pouw, M. A. van Munster, B. C. Burgerhof, J. G. M. de Rooij, S. E. Smidt, N. | Age Ageing | 2020 |
Emergency Department |
| Prevalence, Predictors, and Early Outcomes of Post-operative Delirium in Patients With Type A Aortic Dissection During Intensive Care Unit Stay | Cai, S. Zhang, X. Pan, W. Latour, J. M. Zheng, J. Zhong, J. Gao, J. Lv, M. Luo, Z. Wang, C. Zhang, Y. | Front Med (Lausanne) | 2020 |
delirium |
| Toxin-Induced Acute Delirium | Cai, A. Cai, X. | Neurol Clin | 2020 |
Anticholinergic |
| Cognitive and psychosocial outcomes of mechanically ventilated intensive care patients with and without delirium | Bulic, D. Bennett, M. Georgousopoulou, E. N. Shehabi, Y. Pham, T. Looi, J. C. L. van Haren, F. M. P. | Ann Intensive Care | 2020 |
Cognition |