NIDUS Delirium Bibliography

Delirium Bibliography books graphic What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title: Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients

Authors: Olsen, H. T. Nedergaard, H. K. Strøm, T. Oxlund, J. Wian, K. A. Ytrebø, L. M. Kroken, B. A. Chew, M. Korkmaz, S. Lauridsen, J. T. Toft, P.

Year: 2020

Journal: The New England journal of medicine

Abstract: BACKGROUND: In critically ill, mechanically ventilated patients, daily interruption of sedation has been shown to reduce the time on ventilation and the length of stay in the intensive care unit (ICU). Data on whether a plan of no sedation, as compared with a plan of light sedation, has an effect on mortality are lacking. METHODS: In a multicenter, randomized, controlled trial, we assigned, in a 1:1 ratio, mechanically ventilated ICU patients to a plan of no sedation (nonsedation group) or to a plan of light sedation (i.e., to a level at which the patient was arousable, defined as a score of -2 to -3 on the Richmond Agitation and Sedation Scale [RASS], on which scores range from -5 [unresponsive] to +4 [combative]) (sedation group) with daily interruption. The primary outcome was mortality at 90 days. Secondary outcomes were the number of major thromboembolic events, the number of days free from coma or delirium, acute kidney injury according to severity, the number of ICU-free days, and the number of ventilator-free days. Between-group differences were calculated as the value in the nonsedation group minus the value in the sedation group. RESULTS: A total of 710 patients underwent randomization, and 700 were included in the modified intention-to-treat analysis. The characteristics of the patients at baseline were similar in the two trial groups, except for the score on the Acute Physiology and Chronic Health Evaluation (APACHE) II, which was 1 point higher in the nonsedation group than in the sedation group, indicating a greater chance of in-hospital death. The mean RASS score in the nonsedation group increased from -1.3 on day 1 to -0.8 on day 7 and, in the sedation group, from -2.3 on day 1 to -1.8 on day 7. Mortality at 90 days was 42.4% in the nonsedation group and 37.0% in the sedated group (difference, 5.4 percentage points; 95% confidence interval [CI], -2.2 to 12.2; P = 0.65). The number of ICU-free days and of ventilator-free days did not differ significantly between the trial groups. The patients in the nonsedation group had a median of 27 days free from coma or delirium, and those in the sedation group had a median of 26 days free from coma or delirium. A major thromboembolic event occurred in 1 patient (0.3%) in the nonsedation group and in 10 patients (2.8%) in the sedation group (difference, -2.5 percentage points; 95% CI, -4.8 to -0.7 [unadjusted for multiple comparisons]). CONCLUSIONS: Among mechanically ventilated ICU patients, mortality at 90 days did not differ significantly between those assigned to a plan of no sedation and those assigned to a plan of light sedation with daily interruption. (Funded by the Danish Medical Research Council and others; NONSEDA ClinicalTrials.gov number, NCT01967680.).

PMID: 32068366

Keywords: NCT01967680
acute kidney failure
adult
agitation
APACHE
article
artificial ventilation
coma
controlled study
critically ill patient
delirium
female
human
intensive care unit
major clinical study
male
medical research
mortality
multicenter study
outcome assessment
randomization
randomized controlled trial
sedation
thromboembolism
ventilated patient

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Total Records Found: 6753, showing 100 per page
Title	Authors	Journal	Year	Keywords
Comparison of the prevalence and associated factors of hyperactive delirium in advanced cancer patients between inpatient palliative care and palliative home care	Hamano, J. Mori, M. Ozawa, T. Sasaki, J. Kawahara, M. Nakamura, A. Hashimoto, K. Hisajima, K. Koga, T. Goto, K. Fukumoto, K. Morimoto, Y. Goshima, M. Sekimoto, G. Baba, M. Oya, K. Matsunuma, R. Azuma, Y. Imai, K. Morita, T. Shinjo, T.	Cancer Med	2020	advanced cancer patients hyperactive delirium inpatient palliative care palliative home care place of care
Treatment of delirium in palliative patients - role of neuroleptics	Hainsch-Müller, I. Aulmann, C. Djukic, I.	Internistische Praxis	2020	neuroleptic agent article delirium health practitioner high risk patient human palliative therapy treatment outcome
Identifying Delirium Early after Stroke: A New Prediction Tool for the Intensive Care Unit	Haight, T. N. Marsh, E. B.	J Stroke Cerebrovasc Dis	2020	Adult Age Factors Aged Aged, 80 and over Brain Ischemia/ complications/diagnosis/psychology Comorbidity Delirium/ diagnosis/etiology/psychology Early Diagnosis Female Humans Intensive Care Units Intracranial Hemorrhages/ complications/diagnosis/psychology Male Middle Aged Predictive Value of Tests Reproducibility of Results Risk Assessment Risk Factors Stroke/ complications/diagnosis/psychology Time Factors Delirium Intensive care Outcomes Recovery Stroke
Socioeconomic Factors and Intensive Care Unit-Related Cognitive Impairment	Haddad, D. N. Mart, M. F. Wang, L. Lindsell, C. J. Raman, R. Nordness, M. F. Sharp, K. W. Pandharipande, P. P. Girard, T. D. Ely, E. W. Patel, M. B.	Ann Surg	2020	Aged Cognitive Dysfunction/ epidemiology/etiology Female Humans Intensive Care Units Male Middle Aged Prospective Studies Risk Factors Socioeconomic Factors Time Factors
Opioid use is Associated with ICU Delirium in Mechanically Ventilated Children	Gupta, N. Woolley, A. Talathi, S. Davlyatov, G. Colston, C. Hayes, L.	J Crit Care Med (Targu Mures)	2020	intensive care unit mechanically ventilated children pediatric delirium
A two-year multicenter point prevalence study of older patients with hip fractures admitted to rehabilitation units in Italy	Guerzoni, V. Lanzoni, A. Pozzi, C. Paci, M. Gatti, R. Benedetti, M. G. Gentile, S. Trabucchi, M. Bellelli, G. Morandi, A.	Eur Geriatr Med	2020	Delirium Dementia Elderly Fragility fractures Geriatric syndromes Hip fractures
Preoperative Cognitive Impairment and Postoperative Delirium Predict Decline in Activities of Daily Living after Cardiac Surgery-A Prospective, Observational Cohort Study	Guenther, U. Hoffmann, F. Dewald, O. Malek, R. Brimmers, K. Theuerkauf, N. Putensen, C. Popp, J.	Geriatrics (Basel)	2020	activity of daily living cardiac cognition cognitive delirium intensive care older people outcomes surgery
Risk Factors for Delirium and Cognitive Decline Following Coronary Artery Bypass Grafting Surgery: A Systematic Review and Meta-Analysis	Greaves, D. Psaltis, P. J. Davis, D. H. J. Ross, T. J. Ghezzi, E. S. Lampit, A. Smith, A. E. Keage, H. A. D.	J Am Heart Assoc	2020	cognitive decline coronary artery bypass grafting delirium meta‐analysis
Prevalence and risk factors of delirium in the intensive care unit: An observational study	Gravante, F. Giannarelli, D. Pucci, A. Gagliardi, A. M. Mitello, L. Montagna, A. Latina, R.	Nurs Crit Care	2020	delirium epidemiology intensive care units prevalence risk factors trauma units
Health Care Professionals' Reports of Cancer Pain Cues Among Older People With Delirium: A Qualitative-Quantitative Content Analysis	Graham, C. A. Chaves, G. Harrison, R. Gauthier, L. R. Nissim, R. Zimmermann, C. Chan, V. Rodin, G. Stevens, B. Gagliese, L.	J Pain Symptom Manage	2020	Cancer pain delirium older people pain assessment
Benzodiazepinics and the treatment of delirium: a literature review	Gonçalves, O. H. P. Pellissari, G. M. Paiva, H. S.	Rev Assoc Med Bras (1992)	2020	Benzodiazepines/therapeutic use Cognition Delirium/drug therapy Humans Risk Factors
Analysis of Delirium from the Dynamic Symptoms Model: A Literature Review	Gómez Tovar, L. O. Henao Castaño, A. M.	Critical Care Nursing Quarterly	2020	conceptual framework delirium Dynamic Symptoms Model experience human review symptom assessment systematic review
Association of delirium with long-term cognitive decline: A meta-analysis	Goldberg, T. E. Chen, C. Wang, Y. Jung, E. Swanson, A. Ing, C. Garcia, P. S. Whittington, R. A. Moitra, V.	JAMA Neurology	2020	article cognition cognitive defect delirium disease association effect size follow up human meta analysis priority journal prognosis risk assessment risk factor statistical analysis surgery systematic review
Functional and cognitive decline in older delirious adults after an emergency department visit	Giroux, M. Émond, M. Nadeau, A. Boucher, V. Carmichael, P. H. Voyer, P. Pelletier, M. Gouin, É Daoust, R. Berthelot, S. Lamontagne, M. E. Morin, M. Lemire, S. Sirois, M. J.	Age Ageing	2020	cognitive decline delirium emergency department functional decline older people seniors
The prevalence rates and sequelae of delirium at age older than 90 years	Gehrke, S. Bode, L. Seiler, A. Ernst, J. von Känel, R. Boettger, S.	Palliat Support Care	2020	Delirium Impact of delirium Older than 90 years Prevalence rate Sequelae
Complications of LVAD utilization in older adults	Gazda, A. J. Kwak, M. J. Akkanti, B. Nathan, S. Kumar, S. de Armas, I. S. Baer, P. Patel, B. Kar, B. Gregoric, I. D.	Heart and Lung	2020	aged article clinical feature complication controlled study female heart failure hospital mortality hospital patient human implantation incidence left ventricular assist device major clinical study male outcome assessment postoperative delirium retrospective study
Consolidated framework for advancing implementation science for the implementation process and adherence assessment of a non-pharmacological delirium prevention program	Garrido, M. A. Alvarez, E. A. Ponce, D. P. Salech, F. Tobar, D. I. Tobar, E. A.	Int J Geriatr Psychiatry	2020	Cfir adherence delirium implementation non-pharmacological intervention prevention
Delirium and Adverse Outcomes in Hospitalized Patients with COVID-19	Garcez, F. B. Aliberti, M. J. R. Poco, P. C. E. Hiratsuka, M. Takahashi, S. D. F. Coelho, V. A. Salotto, D. B. Moreira, M. L. V. Jacob-Filho, W. Avelino-Silva, T. J.	Journal of the American Geriatrics Society	2020	mechanical ventilator albumin C reactive protein D dimer adult adverse outcome aged article Brazil controlled study coronavirus disease 2019 delirium disease association female glomerulus filtration rate hospital discharge hospital mortality hospital patient human intensive care unit length of stay longitudinal study lymphocyte count lymphocytopenia major clinical study male medical record review middle aged observational study oxygen therapy prognosis retrospective study telephone interview university hospital very elderly vital sign
The Effects of Melatonin Supplementation on Sleep Quality and Assessment of the Serum Melatonin in ICU Patients: A Randomized Controlled Trial	Gandolfi, J. V. Di Bernardo, A. P. A. Chanes, D. A. V. Martin, D. F. Joles, V. B. Amendola, C. P. Sanches, L. C. Ciorlia, G. L. Lobo, S. M.	Critical care medicine	2020	adult anxiety article artificial ventilation clinical trial controlled study critically ill patient delirium double blind procedure drug therapy enzyme linked immunosorbent assay female hospitalization human human tissue major clinical study male maximum plasma concentration multicenter study night sleep nurse pain prevalence questionnaire randomized controlled trial sleep quality tertiary care center analgesic agent melatonin placebo sedative agent
Atypical presentation of COVID-19 in hospitalised older adults	Gan, J. M. Kho, J. Akhunbay-Fudge, M. Choo, H. M. Wright, M. Batt, F. Mandal, A. K. J. Chauhan, R. Missouris, C. G.	Ir J Med Sci	2020	Atypical symptoms Covid-19 Coronavirus Older adults
Delirium in elderly patients: Prospective prevalence across hospital services	Fuchs, S. Bode, L. Ernst, J. Marquetand, J. von Känel, R. Böttger, S.	Gen Hosp Psychiatry	2020	>65 years Admission Delirium Discharge Elderly Hospital services
Ascertainment of delirium status using natural language processing from electronic health records	Fu, S. Lopes, G. S. Pagali, S. R. Thorsteinsdottir, B. LeBrasseur, N. K. Wen, A. Liu, H. Rocca, W. A. Olson, J. E. St Sauver, J. Sohn, S.	J Gerontol A Biol Sci Med Sci	2020	confusion assessment method delirium electronic health records natural language processing
A Multi-Phase Quality Improvement Initiative for the Treatment of Active Delirium in Older Persons	Friedman, J. I. Li, L. Kirpalani, S. Zhong, X. Freeman, R. Cheng, Y. T. Alfonso, F. L. McAlpine, G. Vakil, A. Macon, B. Francaviglia, P. Cassara, M. LoPachin, V. Reina, K. Davis, K. Reich, D. Craven, C. K. Mazumdar, M. Siu, A. L.	J Am Geriatr Soc	2020	Confusion Assessment Method active delirium treatment program delirium prevention program electronic medical record
Delirium diagnostic tool-provisional (DDT-Pro) scores in delirium, subsyndromal delirium and no delirium	Franco, J. G. Trzepacz, P. T. Sepúlveda, E. Ocampo, M. V. Velásquez-Tirado, J. D. Zaraza, D. R. Restrepo, C. Giraldo, A. M. Serna, P. A. Zuluaga, A. López, C.	Gen Hosp Psychiatry	2020	Cluster analysis Delirium phenotype Geriatric assessment Psychiatric nosology Psychiatric status rating scales Subsyndromal delirium
A multimodal sevoflurane-based sedation regimen in combination with targeted temperature management in post-cardiac arrest patients reduces the incidence of delirium: An observational propensity score-matched study	Foudraine, N. A. Algargoush, A. van Osch, F. H. Bos, A. T.	Resuscitation	2020	Cardiac arrest Delirium Post-anoxic encephalopathy Temperature management Volatile anaesthetics
Association of Plasma Neurofilament Light with Postoperative Delirium	Fong, T. G. Vasunilashorn, S. M. Ngo, L. Libermann, T. A. Dillon, S. T. Schmitt, E. M. Pascual-Leone, A. Arnold, S. E. Jones, R. N. Marcantonio, E. R. Inouye, S. K.	Ann Neurol	2020	Aged Aged, 80 and over Cognition Cognitive Dysfunction/etiology/psychology Cohort Studies Elective Surgical Procedures/adverse effects/psychology Emergence Delirium/ blood/psychology Female Glial Fibrillary Acidic Protein/blood Humans Incidence Male Neurofilament Proteins/ blood Neuropsychological Tests Postoperative Complications/psychology Prospective Studies Psychomotor Performance tau Proteins/blood
Course and Recognition of Poststroke Delirium: A Prospective Noninferiority Trial of Delirium Screening Tools	Fleischmann, R. Warwas, S. Andrasch, T. Kunz, R. Witt, C. Mengel, A. von Sarnowski, B.	Stroke	2020	delirium incidence risk factors screening sensitivity and specificity stroke
The collateral history: an overlooked core clinical skill	Fitzpatrick, D. Doyle, K. Finn, G. Gallagher, P.	Eur Geriatr Med	2020	Clinical training Cognitive impairment Collateral history Delirium Dementia Informant history
Management of delirium superimposed on dementia in a dementia service	FitzGerald, J. Yan, M. Bandecar, A. Ratnasabapathy, V. Rubinsztein, J. Hatfield, C. Ruhi, S.	Progress in Neurology and Psychiatry	2020	adult article automutilation clinical audit cohort analysis delirium dementia female health service home care hospital discharge hospitalization human intensive care unit Lewy body male mental health mental health service middle aged outcome assessment Parkinson disease patient care phenotype posttraumatic stress disorder priority journal psychiatry quality control schizophrenia
Partnering With Family Members to Detect Delirium in Critically Ill Patients	Fiest, K. M. Krewulak, K. D. Ely, E. W. Davidson, J. E. Ismail, Z. Sept, B. G. Stelfox, H. T.	Crit Care Med	2020	adult article brain injury checklist clinical assessment cognition controlled study critically ill patient diagnostic accuracy diagnostic test accuracy study health care quality human informed consent intensive care psychosis intensive care unit major clinical study male nurse patient care receiver operating characteristic Richmond Agitation Sedation Scale sensitivity and specificity spouse tertiary health care university hospital validation study
The correlation of intraoperative hypotension and postoperative cognitive impairment: a meta-analysis of randomized controlled trials	Feng, X. Hu, J. Hua, F. Zhang, J. Zhang, L. Xu, G.	BMC Anesthesiol	2020	Intraoperative hypotension Meta-analysis Postoperative cognitive dysfunction Postoperative delirium
The effect of joints range of motion exercises on delirium prevention in patients admitted to intensive care units	Farzammanesh, A. Jahani, S. Rashidi, M. Maraghi, E. Ravanbakhsh, M.	International Journal of Pharmaceutical and Phytopharmacological Research	2020	IRCT20180114038362N1 adult article checklist clinical outcome controlled study exercise female hospital admission hospital discharge human intensive care psychosis joint mobilization major clinical study male randomized controlled trial range of motion
Sleep and Delirium in Older Adults	Farasat, S. Dorsch, J. J. Pearce, A. K. Moore, A. A. Martin, J. L. Malhotra, A. Kamdar, B. B.	Curr Sleep Med Rep	2020	Acetylcholine Aging Delirium Dopamine Intensive care Sleep
Association between use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and postoperative delirium	Farag, E. Farag, E. Liang, C. Liang, C. Mascha, E. J. Mascha, E. J. Argalious, M. Y. Ezell, J. Maheshwari, K. Esa, W. A. S. Troianos, C. A. Sessler, D. I.	Anesthesiology	2020	adult Alzheimer disease article clinical trial cohort analysis controlled study drug therapy female human incidence intensive care unit major clinical study male neurosurgery postoperative delirium preoperative evaluation randomized controlled trial angiotensin angiotensin receptor antagonist dipeptidyl carboxypeptidase dipeptidyl carboxypeptidase inhibitor endogenous compound
Delirium in cardiology: An old problem, a new emergency	Falsini, G. Romanelli, S. Insana, L. Frongillo, D. Grotti, S. Angioli, P. Ducci, K. Liistro, F. Calchetti, B. Rossi, R. Bolognese, L.	Giornale Italiano di Cardiologia	2020	attitude to illness cardiology delirium human patient care prognosis prophylaxis review
Surveying work-as-done in post-operative delirium risk factors collection and diagnosis monitoring	Falegnami, A. Patriarca, R. Costantino, F. Di Gravio, G. Bilotta, F.	Appl Ergon	2020	RiskSOAP Stamp Team awareness
Psychiatric disorders, delirium and mortality in patients referred for consultation in a burn center: A four-year retrospective study	Erdoğan, E. Delibaş, D. H.	Medical Journal of Bakirkoy	2020	antidepressant agent benzodiazepine derivative neuroleptic agent psychotropic agent acute stress disorder adjustment disorder adult adult respiratory distress syndrome aged anxiety disorder article bipolar disorder burn burn unit cause of death consultation delirium depression drug dependence female heart arrest high risk patient human length of stay major clinical study male mental disease morbidity mortality multiple organ failure psychiatric diagnosis psychosis retrospective study sepsis
Delirium in Older People with COVID-19: Clinical Scenario and Literature Review	Emmerton, D. Abdelhafiz, A.	SN Compr Clin Med	2020	Covid-19 Delirium Hospitalised Management Older people
"It should not be that difficult to manage a condition that is so frequent": A qualitative study on hospital nurses' experience of delirium guidelines	Emme, C.	J Clin Nurs	2020	Adult Delirium/ nursing Disease Management Female Focus Groups Guideline Adherence Health Knowledge, Attitudes, Practice Humans Male Middle Aged Nursing Staff, Hospital/ organization & administration/psychology Qualitative Research barriers clinical guidelines delirium evidence-based practice hospitalised patients interviews nursing
Where should patients with or at risk of delirium be treated in an acute care system? Comparing the rates of delirium in patients receiving usual care versus alternative care: a systematic review and meta-analysis	Ekeozor, C. U. Jeyaruban, D. Lasserson, D.	Int J Clin Pract	2020	Acute care Comparing, Usual care Delirium Hospitalised patients Interventions Prevention Systematic review
Effect of General Versus Spinal Anesthesia on Postoperative Delirium and Early Cognitive Dysfunction in Elderly Patients	Ehsani, R. Djalali Motlagh, S. Zaman, B. Sehat Kashani, S. Ghodraty, M. R.	Anesth Pain Med	2020	Delirium General Anesthesia Pocd Spinal Anesthesia
Anticholinergic Drug Burden and Delirium: A Systematic Review	Egberts, A. Moreno-Gonzalez, R. Alan, H. Ziere, G. Mattace-Raso, F. U. S.	Journal of the American Medical Directors Association	2020	adult Cinahl Cochrane Library delirium Embase female follow up human male Medline PsycINFO review scoring system summer systematic review Web of Science cholinergic receptor blocking agent
Antipsychotics and Lorazepam During Delirium: Are We Harming Older Patients? A Real-Life Data Study	Egberts, A. Alan, H. Ziere, G. Mattace-Raso, F. U. S.	Drugs and Aging	2020	acutely ill patient aged article controlled study delirium drug combination drug therapy female hospital mortality hospitalization human incidence institutionalization major clinical study male medical record review prescription retrospective study risk assessment very elderly lorazepam neuroleptic agent
Delirium in Internal Medicine Departments in a Tertiary Hospital in Israel: Occurrence, Detection Rates, Risk Factors, and Outcomes	Efraim, N. T. Zikrin, E. Shacham, D. Katz, D. Makulin, E. Barski, L. Zeller, L. Bartal, C. Freud, T. Lebedinski, S. Press, Y.	Front Med (Lausanne)	2020	delirium detection rate occurence outcomes risk facors
Development and validation of an aetiology in delirium diagnostic support tool	Eeles, E. Huang, L. Dakin, L. Ling, C. Dunn, E. Fraser, J. Dissanayaka, N. N.	Age Ageing	2020	aetiology algorithm delirium diagnosis differential older people
Association of Geriatric Events With Perioperative Outcomes After Elective Inpatient Surgery	Dworsky, J. Q. Shellito, A. D. Childers, C. P. Copeland, T. P. Maggard-Gibbons, M. Tan, H. J. Saliba, D. Russell, M. M.	J Surg Res	2020	Elderly Elective surgery Frailty Geriatric events Geriatric surgery Older adults
Is there an association between subjective sleep quality and daily delirium occurrence in critically ill adults? A post hoc analysis of a randomised controlled trial	Duprey, M. S. Devlin, J. W. Skrobik, Y.	BMJ Open Respir Res	2020	clinical epidemiology
Approaches to Optimize Medication Data Analysis in Clinical Cohort Studies	Duprey, M. S. Devlin, J. W. Briesacher, B. A. Travison, T. G. Griffith, J. L. Inouye, S. K.	J Am Geriatr Soc	2020	delirium medication older adults pharmacoepidemiology research methods
Delirium definition influences prediction of functional survival in patients one-year postcardiac surgery	Dubiel, C. Hiebert, B. M. Stammers, A. N. Sanjanwala, R. M. Tangri, N. Singal, R. K. Manji, R. A. Rudolph, J. L. Arora, R. C.	J Thorac Cardiovasc Surg	2020	cardiac surgery delirium functional decline postoperative outcomes
Prevalence and outcome of delirium among acute general medical inpatients in Cape Town, South Africa	Du Plooy, N. Day, C. Manning, K. Abdullah, F. James, K. Grace, L. Vorajee, N. April, C. Peter, J. Peter, J. Raubenheimer, P. J.	South African Medical Journal	2020	indwelling urinary catheter creatinine hemoglobin potassium sodium urea adult aphasia article cardiovascular disease central nervous system disease cognitive defect cohort analysis confusion assessment method delirium depression DSM-IV female Glasgow coma scale hearing impairment heart failure hospital admission hospital mortality hospital patient hospital readmission human Human immunodeficiency virus infection ICD-10 immobility interview length of stay leukocyte count major clinical study male moderate renal impairment mortality neurologic disease observational study respiratory failure risk factor urea blood level
Delirium Post-Stroke-Influence on Post-Stroke Dementia (Research Study-Part of the PROPOLIS Study)	Droś, J. Kowalska, K. Pasińska, P. Szyper-Maciejowska, A. Gorzkowska, A. Klimkowicz-Mrowiec, A.	J Clin Med	2020	cognitive impairment post-stroke delirium post-stroke dementia stroke
Providing Evidence-Based Care, Day and Night: A Quality Improvement Initiative to Improve Intensive Care Unit Patient Sleep Quality	Douglas, S. L. Hobbs, H. A. Sibley, S. R. Digby, G. C.	J Intensive Care Med	2020	critical care nursing care quality improvement sleep
An Implementation-Effectiveness Study of a Perioperative Delirium Prevention Initiative for Older Adults	Donovan, A. L. Braehler, M. R. Robinowitz, D. L. Lazar, A. A. Finlayson, E. Rogers, S. Douglas, V. C. Whitlock, E. L.	Anesth Analg	2020	Aged Electronic Health Records/ standards Emergence Delirium/etiology/ prevention & control Female Humans Male Perioperative Care/methods/ standards Practice Guidelines as Topic/ standards Treatment Outcome
Effectiveness of a multidisciplinary comprehensive intervention model based on the Hospital Elderly Life Program to prevent delirium in patients with severe acute pancreatitis	Dong, Z. Song, J. Ge, M. Lin, C. Zhang, J. Chen, J. Wu, Y.	Ann Palliat Med	2020	Pancreatitis aged cognitive function delirium geriatric nursing self-care
Does Preoperative Comprehensive Geriatric Assessment and Frailty Predict Postoperative Complications?	Dogrul, R. T. Dogrul, A. B. Konan, A. Caglar, O. Sumer, F. Caliskan, H. Kizilarslanoglu, M. C. Kilic, M. K. Balci, C. Arik, G. Aycicek, G. S. Ozsurekci, C. Halil, M. Cankurtaran, M. Yavuz, B. B.	World journal of surgery	2020	aged anesthesiologist article Charlson Comorbidity Index complication controlled study delirium female frailty geriatric assessment Geriatric Depression Scale human Katz index major clinical study male Mini Mental State Examination morbidity mortality nutritional assessment postoperative complication preoperative evaluation surgery systolic blood pressure
Preoperative Acute Pain Is Associated with Postoperative Delirium	Ding, X. Gao, X. Chen, Q. Jiang, X. Li, Y. Xu, J. Qin, G. Lu, S. Huang, D.	Pain Med	2020	C-Reactive Protein Postoperative Delirium Preoperative Pain
Effects of electroencephalography and regional cerebral oxygen saturation monitoring on perioperative neurocognitive disorders: a systematic review and meta-analysis	Ding, L. Chen, D. X. Li, Q.	BMC Anesthesiol	2020	Electroencephalography Perioperative neurocognitive disorders Postoperative cognitive decline Postoperative delirium Regional cerebral oxygen saturation
The Addition of Intravenous Propofol and Ketorolac to a Sevoflurane Anesthetic Lessens Emergence Agitation in Children Having Bilateral Myringotomy with Tympanostomy Tube Insertion: A Prospective Observational Study	d'Eon, B. Hackmann, T. Wright, A. S.	Children (Basel)	2020	emergence agitation ketorolac myringotomy pediatric propofol sevoflurane
Preoperative Nutritional Status and Risk for Subsyndromal Delirium in Older Adults Following Joint Replacement Surgery	Denny, D. L. Trotter, T. Lindseth, G.	Orthopedic nursing	2020	aged article cognition controlled study correlational study delirium female human major clinical study male nutritional assessment nutritional status preoperative evaluation prevention replacement arthroplasty risk assessment
Non-pharmacological interventions to reduce the incidence and duration of delirium in critically ill patients: A systematic review and network meta-analysis	Deng, L. X. Cao, L. Zhang, L. N. Peng, X. B. Zhang, L.	J Crit Care	2020	Delirium prevention Intensive care unit Network meta-analysis Non-pharmacological interventions
Multidimensional nursing interventions effect on delirium and hospital admission duration	Dehghani, S. Asadizaker, M. Adineh, M. Maraghi, E. Akbarian, S. Ramezani, B.	International Journal of Pharmaceutical and Phytopharmacological Research	2020	IRCT20181005041233N1 adult article controlled study coronary care unit delirium disease duration emergency ward female hospital admission hospitalization human major clinical study male middle aged Mini Mental State Examination nursing intervention prevalence randomized controlled trial
Effects of pain, sedation and delirium monitoring on clinical and economic outcome: A retrospective study	Deffland, M. Spies, C. Weiss, B. Keller, N. Jenny, M. Kruppa, J. Balzer, F.	PLoS ONE	2020	NCT02265263 adult aged article artificial ventilation clinical effectiveness clinical evaluation clinical outcome cohort analysis controlled study delirium disease severity economics female Germany hospital admission hospital discharge human intensive care unit length of stay machine learning major clinical study male observational study pain patient compliance reimbursement retrospective study sedation
The association of post-operative delirium with health-related quality of life and mortality after lung transplantation	DeBolt, C. Gao, Y. Sutter, N. Soong, A. Trinh, B. N. Kukreja, J. Kleinhenz, M. Venado, A. Leard, L. E. Hays, S. Greenland, J. R. Shah, R. J. Douglas, V. Kolaitis, N. A. Diamond, J. M. Smith, P. J. Singer, J. P.	American Journal of Respiratory and Critical Care Medicine	2020	adult conference abstract controlled study depression female gender human human tissue intensive care unit Kaplan Meier method lung disease lung transplantation major clinical study male medical record mixed cell culture mortality risk postoperative delirium primary graft dysfunction quality of life Short Form 12 surgery
Development and validation of a delirium risk prediction preoperative model for cardiac surgery patients (DELIPRECAS): An observational multicentre study	de la Varga-Martínez, O. Gómez-Pesquera, E. Muñoz-Moreno, M. F. Marcos-Vidal, J. M. López-Gómez, A. Rodenas-Gómez, F. Ramasco, F. Álvarez-Refojo, F. Tamayo, E. Gómez-Sánchez, E.	J Clin Anesth	2020	Cardiac surgery Delirium Prevention Risk factors
The Effect of Multiple Assessments on Delirium Detection: a Pilot Study	de Freitas, S. A. Wong, E. Lee, J. Y. Reppas-Rindlisbacher, C. Gabor, C. Curkovic, A. Patterson, C. J.	Can Geriatr J	2020	3d-cam delirium multiple observations orthopedic point-prevalence
Delirium Detection Based on the Clinical Experience of Pediatric Intensivists	de Castro, R. E. V. de Magalhães-Barbosa, M. C. Cunha, Ajlad Cheniaux, E. Prata-Barbosa, A.	Pediatr Crit Care Med	2020
Kidney Function Modifies the Effect of Intraoperative Opioid Dosage on Postoperative Delirium	Davani, A. B. Snyder, S. H. Oh, E. S. Mears, S. C. Crews, D. C. Wang, N. Y. Sieber, F. E.	J Am Geriatr Soc	2020	analgesics, opioids delirium, postoperative hip fracture kidney
One-year mortality rate after fragility hip fractures and associated risk in Nan, Thailand	Daraphongsataporn, N. Saloa, S. Sriruanthong, K. Philawuth, N. Waiwattana, K. Chonyuen, P. Pimolbutr, K. Sucharitpongpan, W.	Osteoporosis and Sarcopenia	2020	aged article cohort analysis delirium electronic medical record end stage renal disease female fragility fracture health statistics hip fracture hospital discharge human major clinical study male medical record review mortality rate pneumonia retrospective study risk factor Thailand
Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related?	Daou, M. Telias, I. Younes, M. Brochard, L. Wilcox, M. E.	Front Neurol	2020	ICU acquired delirium circadian rhythm intervention mechanisms sleep
Delirium prevention and treatment in the emergency department (ED): a systematic review protocol	Dahlstrom, E. B. Han, J. H. Healy, H. Kennedy, M. Arendts, G. Lee, J. Carpenter, C. Lee, S.	BMJ Open	2020	accident & emergency medicine delirium & cognitive disorders geriatric medicine
Pathomechanisms of Non-Traumatic Acute Brain Injury in Critically Ill Patients	Dabrowski, W. Siwicka-Gieroba, D. Gasinska-Blotniak, M. Zaid, S. Jezierska, M. Pakulski, C. Williams Roberson, S. Wesley Ely, E. Kotfis, K.	Medicina (Kaunas)	2020	critical illness delirium gastrointestinal microbiome hyperoxia hypoxia kynurenine pathway neuroinflammation neurotransmitter agents tryptophan
Low molecular weight heparin in COVID-19 patients prevents delirium and shortens hospitalization	D’Ardes, D. Carrarini, C. Russo, M. Dono, F. Speranza, R. Digiovanni, A. Martinotti, G. Di Iorio, A. Onofrj, M. Cipollone, F. Bonanni, L.	Neurological Sciences	2020	adult article cognitive defect cohort analysis comorbidity complication controlled study coronavirus disease 2019 drug therapy female hospitalization human intensive care unit length of stay major clinical study male prevention C reactive protein endogenous compound enoxaparin
Postoperative delirium: why, what, and how to confront it at your institution	Curtis, M. S. Forman, N. A. Donovan, A. L. Whitlock, E. L.	Curr Opin Anaesthesiol	2020	Aged Delirium/ prevention & control Humans Perioperative Care Postoperative Complications
Delirium due to intoxication with quetiapine: A systematic literature review	Crombez, S. van Den Wijngaert, V. Demyttenaere, K. de Fruyt, J.	Tijdschrift voor Psychiatrie	2020	physostigmine quetiapine agitation article delirium drug intoxication human incidence systematic review
Postoperative delirium in patients with head and neck oral cancer in the West of Scotland	Crawford, J. E. Zubair, F. Baniulyte, G. Wales, C. J. Ansell, M. Thomson, E. Hislop, S. MacIver, C. Devine, J. McCaul, J. Young, D. McMahon, J.	Br J Oral Maxillofac Surg	2020	Eras Head and neck delirium free flap oral cancer postoperative care
Diagnosis, prevention, and management of delirium in the intensive cardiac care unit	Cortés-Beringola, A. Vicent, L. Martín-Asenjo, R. Puerto, E. Domínguez-Pérez, L. Maruri, R. Moreno, G. Vidán, M. T. Fernando, Arribas Bueno, H.	Am Heart J	2020
Serum DBI and biomarkers of neuroinflammation in Alzheimer's disease and delirium	Conti, E. Andreoni, S. Tomaselli, D. Storti, B. Brovelli, F. Acampora, R. Da Re, F. Appollonio, I. Ferrarese, C. Tremolizzo, L.	Neurol Sci	2020	Alzheimer’s disease Cytokines Delirium Diazepam binding inhibitor Monocytes Serum
A complication of coronavirus disease 2019: delirium	Cipriani, G. Danti, S. Nuti, A. Carlesi, C. Lucetti, C. Di Fiorino, M.	Acta Neurol Belg	2020	Betacoronavirus Covid-19 Coronavirus Infections/ complications Delirium/ virology Humans Pandemics Pneumonia, Viral/ complications SARS-CoV-2 Delirium Dementia Intensive-care unit
Post-operative delirium and cognitive decline in kidney transplantation	Chu, N. M. Chen, X. Segev, D. L. McAdams-DeMarco, M.	Journal of the American Society of Nephrology	2020	adult cognitive defect cohort analysis conference abstract controlled study executive function female human kidney transplantation major clinical study male medical record memory nephrologist postoperative delirium
Vitamin D and Delirium in Older Adults: A Case-Control Study in Geriatric Acute Care Unit	Chouët, J. Sacco, G. Karras, S. N. Llewellyn, D. J. Sánchez-Rodríguez, D. Annweiler, C.	Front Neurol	2020	cognition delirium neuroendocrinology older adults vitamin D
Risk factors for postoperative delirium in elderly patients after spinal fusion surgery	Choi, S. Jung, I. Yoo, B. Lee, S. Kim, M. C.	Anesth Pain Med (Seoul)	2020	Aged Anesthesia, general Delirium Postoperative complication Risk factors Spinal, surgery
Multimodal Education Program to Improve Nurses' Knowledge and Confidence on Delirium Recognition in a Surgical-Trauma Intermediate-Care Setting	Choi, M. DeGennaro, R. Blevins, C.	Journal of doctoral nursing practice	2020	adult article controlled study delirium education program human intermediate care unit learning nurse nursing unit pretest posttest design simulation surgical injury university hospital videorecording
Development and validation of delirium prediction model for critically ill adults parameterized to ICU admission acuity	Cherak, S. J. Soo, A. Brown, K. N. Ely, E. W. Stelfox, H. T. Fiest, K. M.	PLoS One	2020	Apache Adult Aged Critical Illness Decision Support Techniques Delirium/ diagnosis Female Hospitalization/ statistics & numerical data Humans Intensive Care Units/ statistics & numerical data Male Middle Aged Prospective Studies ROC Curve Retrospective Studies Risk Factors
Association of Glucose Variability and ICU Delirium of Patients after Liver Transplantation	Cheng, J. L. Dong, M. L. Zhang, Z. W. Liao, X. L. Yang, J. Y. Kang, Y.	Journal of Sichuan University. Medical science edition	2020	adverse event cohort analysis delirium glucose blood level human intensive care unit liver transplantation retrospective study risk factor
Modified Frailty Index Independently Predicts Postoperative Delirium and Delayed Neurocognitive Recovery After Elective Total Joint Arthroplasty	Chen, Y. Qin, J.	J Arthroplasty	2020	delayed neurocognitive recovery delirium modified frailty index osteoarthritis total joint arthroplasty
Risk predictive models for delirium in the intensive care unit: a systematic review and meta-analysis	Chen, X. Lao, Y. Zhang, Y. Qiao, L. Zhuang, Y.	Ann Palliat Med	2020	Delirium intensive care units meta-analysis prediction model
Diagnostic accuracy of the CAM-ICU and ICDSC in detecting intensive care unit delirium: A bivariate meta-analysis	Chen, T. J. Chung, Y. W. Chang, H. C. R. Chen, P. Y. Wu, C. R. Hsieh, S. H. Chiu, H. Y.	International journal of nursing studies	2020	adult artificial ventilation checklist Cinahl critically ill patient diagnostic accuracy diagnostic test accuracy study Embase female human intensive care psychosis medical intensive care unit Medline meta analysis outpatient patient selection review sensitivity and specificity standard systematic review
Atypical Sleep and Postoperative Delirium in the Cardiothoracic Surgical Intensive Care Unit: A Pilot Prospective Study	Chen, Q. Peng, Y. Lin, Y. Li, S. Huang, X. Chen, L. W.	Nat Sci Sleep	2020	atypical sleep cardiac surgery intensive care unit postoperative delirium
Delirium risk prediction models for intensive care unit patients: A systematic review	Chen, J. Yu, J. Zhang, A.	Intensive Crit Care Nurs	2020	Delirium Icu Prediction model Systematic review
The role of statins in the management of delirium: Recent advances	Chen, J. Wang, Y. Hu, X. Li, M. Xiong, K. Zhang, Z. Chen, Q.	CNS Neurol Disord Drug Targets	2020	Delirium cerebral hypoperfusion microthrombosis neurotransmitters statins systemic neuroinflammation
Analysis of Risk Factors for Postoperative Delirium After Liver Transplantation	Chen, J. Wang, H. He, Z. Li, T.	Neuropsychiatr Dis Treat	2020	ammonia hepatic encephalopathy liver transplantation postoperative delirium risk factors
Analgesia and sedation in patients with ARDS	Chanques, G. Constantin, J. M. Devlin, J. W. Ely, E. W. Fraser, G. L. Gélinas, C. Girard, T. D. Guérin, C. Jabaudon, M. Jaber, S. Mehta, S. Langer, T. Murray, M. J. Pandharipande, P. Patel, B. Payen, J. F. Puntillo, K. Rochwerg, B. Shehabi, Y. Strøm, T	Intensive Care Med	2020	Analgesia/methods/ standards Guidelines as Topic Humans Hypnotics and Sedatives/ therapeutic use Pain Management/methods Respiratory Distress Syndrome/ drug therapy Acute respiratory distress syndrome Analgesia Covid-19 Intensive care unit Mechanical ventilation Rehabilitation Sedation
Delirium Prevention, Detection, and Treatment in Emergency Medicine Settings: A Geriatric Emergency Care Applied Research (GEAR) Network Scoping Review and Consensus Statement	Carpenter, C. R. Hammouda, N. Linton, E. A. Doering, M. Ohuabunwa, U. K. Ko, K. J. Hung, W. W. Shah, M. N. Lindquist, L. A. Biese, K. Wei, D. Hoy, L. Nerbonne, L. Hwang, U. Dresden, S. M.	Academic Emergency Medicine	2020	aged applied research article consensus controlled study delirium education emergency care emergency medicine emergency physician emergency ward female geriatrician gestalt psychology human intervention study librarian male meta analysis nurse pharmacist phenotype Preferred Reporting Items for Systematic Reviews and Meta-Analyses prevalence prevention prevention study randomized controlled trial (topic) sensitivity and specificity social worker systematic review
Geriatric emergency care applied research network cognitive impairment priorities consensus conference	Carpenter, C. R. Hammouda, N. Linton, E. Doerring, M. Ohuabunwa, U. Ko, K. Hung, W. Dresden, S. M. Shah, M. N. Lindquist, L. Biese, K. Wei, D. Hwang, U.	Academic Emergency Medicine	2020	adult aging applied research care bundle clinical assessment cognitive defect conference abstract controlled study diagnostic accuracy diagnostic test accuracy study emergency care emergency medicine emergency ward female geriatrics human implementation science incidence intensive care language leadership length of stay librarian male multicenter study (topic) nurse pharmacy (discipline) phenotype physician pilot study Preferred Reporting Items for Systematic Reviews and Meta-Analyses prevention psychology randomized controlled trial (topic) research priority social work systematic review workload
Identifying and Responding to Delirium in Acute Stroke: Clinical Team Members' Understandings	Carin-Levy, G. Nicol, K. van Wijck, F. Mead, G. McVittie, C.	Qualitative health research	2020	adult article clinical article controlled study delirium female grounded theory human interview male nurse occupational therapist physiotherapist Scotland speech language pathologist stroke survivor stroke unit vignette
Antipsychotic use in the prevention and treatment of intensive care unit delirium in pediatric patients	Capino, A. C. Thomas, A. N. Baylor, S. Hughes, K. M. Miller, J. L. Johnson, P. N.	Journal of Pediatric Pharmacology and Therapeutics	2020	haloperidol midazolam neuroleptic agent olanzapine quetiapine risperidone child consciousness disorder drug efficacy dystonia extrapyramidal symptom fever human hyperpyrexia hypersalivation intensive care psychosis muscle rigidity oculogyric crisis QT prolongation review tachycardia tremor
Screening instruments for cognitive impairment in older patients in the Emergency Department: a systematic review and meta-analysis	Calf, A. H. Pouw, M. A. van Munster, B. C. Burgerhof, J. G. M. de Rooij, S. E. Smidt, N.	Age Ageing	2020	Emergency Department cognitive impairment delirium dementia older people screening
Prevalence, Predictors, and Early Outcomes of Post-operative Delirium in Patients With Type A Aortic Dissection During Intensive Care Unit Stay	Cai, S. Zhang, X. Pan, W. Latour, J. M. Zheng, J. Zhong, J. Gao, J. Lv, M. Luo, Z. Wang, C. Zhang, Y.	Front Med (Lausanne)	2020	delirium early outcomes incidence risk factors type A aortic dissection
Toxin-Induced Acute Delirium	Cai, A. Cai, X.	Neurol Clin	2020	Anticholinergic Delirium GABA withdrawal Hallucinogen Sympathomimetic Toxidrome Wernicke
Cognitive and psychosocial outcomes of mechanically ventilated intensive care patients with and without delirium	Bulic, D. Bennett, M. Georgousopoulou, E. N. Shehabi, Y. Pham, T. Looi, J. C. L. van Haren, F. M. P.	Ann Intensive Care	2020	Cognition Delirium Intensive care Long-term outcomes Post-traumatic stress disorder Psychosocial function