What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.
- Authors
- Miller, D. Lewis, S. R. Pritchard, M. W. Schofield-Robinson, O. J. Shelton, C. L. Alderson, P. Smith, A. F.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
BACKGROUND: The use of anaesthetics in the elderly surgical population (more than 60 years of age) is increasing. Postoperative delirium, an acute condition characterized by reduced awareness of the environment and a disturbance in attention, typically occurs between 24 and 72 hours after surgery and can affect up to 60% of elderly surgical patients. Postoperative cognitive dysfunction (POCD) is a new-onset of cognitive impairment which may persist for weeks or months after surgery.Traditionally, surgical anaesthesia has been maintained with inhalational agents. End-tidal concentrations require adjustment to balance the risks of accidental awareness and excessive dosing in elderly people. As an alternative, propofol-based total intravenous anaesthesia (TIVA) offers a more rapid recovery and reduces postoperative nausea and vomiting. Using TIVA with a target controlled infusion (TCI) allows plasma and effect-site concentrations to be calculated using an algorithm based on age, gender, weight and height of the patient.TIVA is a viable alternative to inhalational maintenance agents for surgical anaesthesia in elderly people. However, in terms of postoperative cognitive outcomes, the optimal technique is unknown. OBJECTIVES: To compare maintenance of general anaesthesia for elderly people undergoing non-cardiac surgery using propofol-based TIVA or inhalational anaesthesia on postoperative cognitive function, mortality, risk of hypotension, length of stay in the postanaesthesia care unit (PACU), and hospital stay. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2017, Issue 11), MEDLINE (1946 to November 2017), Embase (1974 to November 2017), PsycINFO (1887 to November 2017). We searched clinical trials registers for ongoing studies, and conducted backward and forward citation searching of relevant articles. SELECTION CRITERIA: We included randomized controlled trials (RCTs) with participants over 60 years of age scheduled for non-cardiac surgery under general anaesthesia. We planned to also include quasi-randomized trials. We compared maintenance of anaesthesia with propofol-based TIVA versus inhalational maintenance of anaesthesia. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed studies for inclusion, extracted data, assessed risk of bias, and synthesized findings. MAIN RESULTS: We included 28 RCTs with 4507 randomized participants undergoing different types of surgery (predominantly cardiovascular, laparoscopic, abdominal, orthopaedic and ophthalmic procedures). We found no quasi-randomized trials. Four studies are awaiting classification because we had insufficient information to assess eligibility.All studies compared maintenance with propofol-based TIVA versus inhalational maintenance of anaesthesia. Six studies were multi-arm and included additional TIVA groups, additional inhalational maintenance or both. Inhalational maintenance agents included sevoflurane (19 studies), isoflurane (eight studies), and desflurane (three studies), and was not specified in one study (reported as an abstract). Some studies also reported use of epidural analgesia/anaesthesia, fentanyl and remifentanil.We found insufficient reporting of randomization methods in many studies and all studies were at high risk of performance bias because it was not feasible to blind anaesthetists to study groups. Thirteen studies described blinding of outcome assessors. Three studies had a high of risk of attrition bias, and we noted differences in the use of analgesics between groups in six studies, and differences in baseline characteristics in five studies. Few studies reported clinical trials registration, which prevented assessment of risk of selective reporting bias.We found no evidence of a difference in incidences of postoperative delirium according to type of anaesthetic maintenance agents (odds ratio (OR) 0.59, 95% confidence interval (CI) 0.15 to 2.26; 321 participants; five studies; very low-certainty evidence); we noted during sensitivity analysis that using different time points in one study may influence direction of this result. Thirteen studies (3215 participants) reported POCD, and of these, six studies reported data that could not be pooled; we noted no difference in scores of POCD in four of these and in one study, data were at a time point incomparable to other studies. We excluded one large study from meta-analysis because study investigators had used non-standard anaesthetic management and this study was not methodologically comparable to other studies. We combined data for seven studies and found low-certainty evidence that TIVA may reduce POCD (OR 0.52, 95% CI 0.31 to 0.87; 869 participants).We found no evidence of a difference in mortality at 30 days (OR 1.21, 95% CI 0.33 to 4.45; 271 participants; three studies; very low-certainty evidence). Twelve studies reported intraoperative hypotension. We did not perform meta-analysis for 11 studies for this outcome. We noted visual inconsistencies in these data, which may be explained by possible variation in clinical management and medication used to manage hypotension in each study (downgraded to low-certainty evidence); one study reported data in a format that could not be combined and we noted little or no difference between groups in intraoperative hypotension for this study. Eight studies reported length of stay in the PACU, and we did not perform meta-analysis for seven studies. We noted visual inconsistencies in these data, which may be explained by possible differences in definition of time points for this outcome (downgraded to very low-certainty evidence); data were unclearly reported in one study. We found no evidence of a difference in length of hospital stay according to type of anaesthetic maintenance agent (mean difference (MD) 0 days, 95% CI -1.32 to 1.32; 175 participants; four studies; very low-certainty evidence).We used the GRADE approach to downgrade the certainty of the evidence for each outcome. Reasons for downgrading included: study limitations, because some included studies insufficiently reported randomization methods, had high attrition bias, or high risk of selective reporting bias; imprecision, because we found few studies; inconsistency, because we noted heterogeneity across studies. AUTHORS’ CONCLUSIONS: We are uncertain whether maintenance with propofol-based TIVA or with inhalational agents affect incidences of postoperative delirium, mortality, or length of hospital stay because certainty of the evidence was very low. We found low-certainty evidence that maintenance with propofol-based TIVA may reduce POCD. We were unable to perform meta-analysis for intraoperative hypotension or length of stay in the PACU because of heterogeneity between studies. We identified 11 ongoing studies from clinical trials register searches; inclusion of these studies in future review updates may provide more certainty for the review outcomes.
- PMID
- Keywords
Aged
Anesthesia, Inhalation
Anesthesia, Intravenous
Anesthetics, Inhalation
Anesthetics, Intravenous/*adverse effects
Cognition/*drug effects
Cognition Disorders/chemically induced
Delirium/chemically induced
Desflurane
Humans
Hypotension/chemically induced
Isoflurane/adverse effects/analogs & derivatives
Methyl Ethers/adverse effects
Middle Aged
Postoperative Complications/chemically induced/mortality
Propofol/*adverse effects
Randomized Controlled Trials as Topic
Sevoflurane
*Surgical Procedures, Operative
- Page(s)
- Volume
- 8
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| American Society for Enhanced Recovery and Perioperative quality initiative joint consensus statement on the role of neuromonitoring in perioperative outcomes: Electroencephalography | Chan, M. T. V. Hedrick, T. L. Egan, T. D. García, P. S. Koch, S. Purdon, P. L. Ramsay, M. A. Miller, T. E. McEvoy, M. D. Gan, T. J. Hughes, C. G. Boncyk, C. S. Culley, D. J. Fleisher, L. A. Leung, J. M. McDonagh, D. L. Thiele, R. H. Shaw, A. Bartels, K. | Anesthesia and Analgesia | 2020 |
anesthesiologist |
| Evidence-based clinical practice guidelines for the management of sedoanalgesia and delirium in critically ill adult patients | Celis-Rodríguez, E. Díaz Cortés, J. C. Cárdenas Bolívar, Y. R. Carrizosa González, J. A. Pinilla, D. I. Ferrer Záccaro, L. E. Birchenall, C. Caballero López, J. Argüello, B. M. Castillo Abrego, G. Castorena Arellano, G. Dueñas Castell, C. Jáure | Med Intensiva | 2020 |
Agitación |
| Patient care during the COVID-19 pandemic: do not leave delirium behind | Castro, R. E. V. Garcez, F. B. Avelino-Silva, T. J. | Braz J Psychiatry | 2020 | |
| The financial and social costs of delirium | Caplan, G. A. Teodorczuk, A. Streatfeild, J. Agar, M. R. | European Geriatric Medicine | 2020 |
cost control |
| Clinical impression for identification of vulnerable older patients in the emergency department | Calf, A. H. Lubbers, S. van den Berg, A. A. van den Berg, E. Jansen, C. J. van Munster, B. C. de Rooij, S. E. Ter Maaten, J. C. | Eur J Emerg Med | 2020 | |
| Is Delirium Pediatric Confusion Assessment Method Tools Confiable? | Caino de Oliveira, F. R. Ribeiro de Araujo, O. Brunow de Carvalho, W. | Pediatr Crit Care Med | 2020 |
Brazil |
| Research in brief: Inpatient hip fractures and nomenclature of delirium and acute encephalopathy | Cacciottolo, T. M. Ferrigan, L. | Clin Med (Lond) | 2020 | |
| Prolonged Confusional state as first manifestation of COVID-19 | Butt, I. Sawlani, V. Geberhiwot, T. | Ann Clin Transl Neurol | 2020 |
Covid-19 |
| Delirium After Withdrawal From Valerian Root: A Case Report | Burke, H. Jiang, S. Chatham, P. Stern, T. A. | Psychosomatics | 2020 | |
| Deciphering delirium through semantics: a selective synopsis | Bugiani, O. | Neurol Sci | 2020 |
Ageing |
| Predicting incident delirium diagnoses using data from primary-care electronic health records | Bowman, K. Jones, L. Masoli, J. Mujica-Mota, R. Strain, D. Butchart, J. Valderas, J. M. Fortinsky, R. H. Melzer, D. Delgado, J. | Age Ageing | 2020 |
at home |
| Comparison of Self-Reported and Behavioral Pain Assessment Tools in Critically Ill Patients | Bouajram, R. H. Sebat, C. M. Love, D. Louie, E. L. Wilson, M. D. Duby, J. J. | J Intensive Care Med | 2020 |
Behavioral Pain Scale |
| Practical Training of Anesthesia Clinicians in Electroencephalogram-Based Determination of Hypnotic Depth of General Anesthesia | Bombardieri, A. M. Wildes, T. S. Stevens, T. Wolfson, M. Steinhorn, R. Ben Abdallah, A. Sleigh, J. Avidan, M. S. | Anesth Analg | 2020 |
Anesthesia, Inhalation |
| A multisite study of nurse-reported perceptions and practice of ABCDEF bundle components | Boehm, L. M. Pun, B. T. Stollings, J. L. Girard, T. D. Rock, P. Hough, C. L. Hsieh, S. J. Khan, B. A. Owens, R. L. Schmidt, G. A. Smith, S. Ely, E. W. | Intensive Crit Care Nurs | 2020 |
ABCDEF bundle |
| Cognitive impairment, clinical symptoms and functional disability in patients emerging from the minimally conscious state | Bodien, Y. G. Martens, G. Ostrow, J. Sheau, K. Giacino, J. T. | NeuroRehabilitation | 2020 |
adult |
| Effect of intravenous iron on functional outcomes in hip fracture: a randomised controlled trial | Bielza, R. Llorente, J. Thuissard, I. J. Andreu-Vázquez, C. Blanco, D. Sanjurjo, J. López, N. Herráez, M. R. Molano, C. Morales, A. Arias, E. Neira, M. Lung, A. Escalera, J. Portillo, L. Larrubia, Y. García, C. Zambrana, F. Gómez Cerezo, J. | Age Ageing | 2020 |
anaemia |
| Tapering with Pharmaceutical GHB or Benzodiazepines for Detoxification in GHB-Dependent Patients: A Matched-Subject Observational Study of Treatment-as-Usual in Belgium and The Netherlands | Beurmanjer, H. Luykx, J. J. De Wilde, B. van Rompaey, K. Buwalda, V. J. A. De Jong, C. A. J. Dijkstra, B. A. G. Schellekens, A. F. A. | CNS Drugs | 2020 | |
| Clinical characteristics and outcomes of inpatients with neurologic disease and COVID-19 in Brescia, Lombardy, Italy | Benussi, A. Pilotto, A. Premi, E. Libri, I. Giunta, M. Agosti, C. Alberici, A. Baldelli, E. Benini, M. Bonacina, S. Brambilla, L. Caratozzolo, S. Cortinovis, M. Costa, A. Piccinelli, S. C. Cottini, E. Cristillo, V. Delrio, I. Filosto, M. Gamba, M. Gazzina | Neurology | 2020 | |
| Palliative sedation: beliefs and decision-making among Spanish palliative care physicians | Benítez-Rosario, M. A. Ascanio-León, B. | Support Care Cancer | 2020 |
Cancer patients |
| A Tunisian version of the confusion assessment method for the intensive care unit (CAM-ICU): translation and validation | Ben Saida, I. Kortli, S. Amamou, B. Kacem, N. Ghardallou, M. Ely, E. W. Ben Saad, H. Boussarsar, M. | BMC Psychiatry | 2020 |
Critical illness |
| 'Socialised care futility' in the care of older people in hospital who call out repetitively: An ethnographic study | Beaver, J. Goldberg, S. E. Edgley, A. Harwood, R. H. | Int J Nurs Stud | 2020 |
Acute hospitals |
| Delirium in COVID-19: A case series and exploration of potential mechanisms for central nervous system involvement | Beach, S. R. Praschan, N. C. Hogan, C. Dotson, S. Merideth, F. Kontos, N. Fricchione, G. L. Smith, F. A. | Gen Hosp Psychiatry | 2020 |
Akinetic mutism |
| Prevalence of delirium in intensive care patients and association with sedoanalgesia, severity and mortality | Bastos, A. S. Beccaria, L. M. Silva, D. C. D. Barbosa, T. P. | Revista gaucha de enfermagem | 2020 |
adult |
| Antipsychotics and the Risk of Mortality or Cardiopulmonary Arrest in Hospitalized Adults | Basciotta, M. Zhou, W. Ngo, L. Donnino, M. Marcantonio, E. R. Herzig, S. J. | J Am Geriatr Soc | 2020 |
antipsychotics |
| Comprehensive analysis of in-hospital delirium after major surgical oncology procedures: A population-based study | Bandini, M. Marchioni, M. Preisser, F. Nazzani, S. Tian, Z. Graefen, M. Montorsi, F. Saad, F. Shariat, S. F. Schips, L. Briganti, A. Karakiewicz, P. I. | Can Urol Assoc J | 2020 |
adult |
| Sepsis Associated Delirium | Atterton, B. Paulino, M. C. Povoa, P. Martin-Loeches, I. | Medicina (Kaunas) | 2020 |
adult |
| Melatonin for delirium prevention in acute medically ill, and perioperative geriatric patients | Asleson, D. R. Chiu, A. W. | Aging Medicine | 2020 |
adult |
| The short- And long-term outcomes of esophagectomy for esophageal cancer in patients older than 75 years | Aoyama, T. Hara, K. Kazama, K. Atsumi, Y. Tamagawa, H. Tamagawa, A. MacHida, D. Komori, K. Maezawa, Y. Kano, K. Hashimoto, I. Oshima, T. Murakawa, M. Numata, M. Yukawa, N. Masuda, M. Rino, Y. | Anticancer Research | 2020 |
antineoplastic agent |
| National French survey of COVID-19 symptoms in people aged 70 and over | Annweiler, C. Sacco, G. Salles, N. Aquino, J. P. Gautier, J. Berrut, G. Guérin, O. Gavazzi, G. | Clin Infect Dis | 2020 | |
| COVID-19: ICU delirium management during SARS-CoV-2 pandemic-pharmacological considerations | Andrews, L. J. Benken, S. T. | Crit Care | 2020 |
Betacoronavirus |
| The Intersection of Architecture/Medicine/Quality and the Clinical Nurse Specialist: Designing for the Prevention of Delirium | Anderson, D. C. Jacoby, S. R. Scruth, E. A. | Clinical nurse specialist CNS | 2020 | |
| The Agents Intervening against Delirium in the Intensive Care Unit-Trial (AID-ICU trial):- a detailed statistical analysis plan | Andersen-Ranberg, N. Poulsen, L. M. Perner, A. Wetterslev, J. Mathiesen, O. Mortensen, C. B. Estrup, S. Ebdrup, B. H. Hästbacka, J. Citerio, G. Caballero, J. Morgan, M. P. G. Oxenbøll-Collet, M. Weber, S. O. Andreasen, A. S. Bestle, M. H. Pedersen, H. B | Acta Anaesthesiol Scand | 2020 | |
| A systematic review of the overlap of fluid biomarkers in delirium and advanced cancer-related syndromes | Amgarth-Duff, I. Hosie, A. Caplan, G. Agar, M. | BMC Psychiatry | 2020 |
Advanced cancer |
| Toward best practice methods for delirium biomarker studies: An international modified Delphi study | Amgarth-Duff, I. Hosie, A. Caplan, G. Agar, M. | Int J Geriatr Psychiatry | 2020 |
consensus |
| Preoperative cognitive dysfunction in older elective noncardiac surgical patients in South Africa | Amado, L. A. Perrie, H. Scribante, J. Ben-Israel, K. A. | Br J Anaesth | 2020 |
Mini-Cog |
| The etiology and age-related properties of patients with delirium in coronary intensive care unit and its effects on inhospital and follow up prognosis | Altay, S. Gürdoğan, M. Kaya, Ç Kardaş, F. Zeybey, U. Çakir, B. Ebik, M. Demir, M. | Ideggyogy Sz | 2020 |
delirium in coronary intensive care unit |
| A Unique Presentation of Delirium in a Patient with Otherwise Asymptomatic COVID-19 | Alkeridy, W. A. Almaghlouth, I. Alrashed, R. Alayed, K. Binkhamis, K. Alsharidi, A. Liu-Ambrose, T. | J Am Geriatr Soc | 2020 |
Covid-19 |
| Postoperative delirium after abdominal aortic surgery: after ICU discharge surveillance should extend to the surgical ward | Alessandri, F. Bilotta, F. | Minerva Anestesiol | 2020 | |
| The prevalence of emergence delirium and its associated factors among children at a postoperative unit: A retrospective cohort at a Middle Eastern hospital | Aldakhil, S. K. Salam, M. Albelali, A. A. Alkanhal, R. M. Alnemer, M. J. Alatassi, A. | Saudi J Anaesth | 2020 |
Anesthesia |
| Optimal goal of management of delirium in end-of-life cancer care | Akechi, T. | Lancet Oncol | 2020 | |
| Multiple Peri-Operative Complications are Associated with Reduced Long Term Amputation Free Survival Following Revascularisation for Lower Limb Peripheral Artery Disease: A Population Based Linked Data Study | Aitken, S. J. Randall, D. A. Noguchi, N. Blyth, F. M. Naganathan, V. | Eur J Vasc Endovasc Surg | 2020 |
Aged |
| Neurological manifestations and complications of COVID-19: A literature review | Ahmad, I. Rathore, F. A | J Clin Neurosci | 2020 |
Clinical features |
| The role of suvorexant in the prevention of delirium during acute hospitalization: A systematic review | Adams, A. D. Pepin, M. J. Brown, J. N. | J Crit Care | 2020 |
Belsomra |
| Quetiapine for delirium prophylaxis in high-risk critically ill patients | Abraham, M. P. Hinds, M. Tayidi, I. Jeffcoach, D. R. Corder, J. M. Hamilton, L. A. Lawson, C. M. Bollig, R. W. Heidel, R. E. Daley, B. J. Taylor, J. E. McMillen, J. C. | Surgeon | 2020 |
Delirium |
| Comparing outcomes after peripheral nerve block versus general anesthesia for lower extremity amputation: a nationwide exploratory retrospective cohort study in Japan | Abe, H. Sumitani, M. Matsui, H. Aso, S. Inoue, R. Fushimi, K. Uchida, K. Yasunaga, H. Yamada, Y. | Reg Anesth Pain Med | 2020 |
lower extremity |
| Development of delirium: Association with old age, severe burns, and intensive care | Abdelrahman, I. Vieweg, R. Irschik, S. Steinvall, I. Sjöberg, F. Elmasry, M. | Burns | 2020 |
Burns |
| Factors Associated With Postoperative Confusion and Prolonged Hospital Stay Following Deep Brain Stimulation Surgery for Parkinson Disease | Abboud, H. Genc, G. Saad, S. Thompson, N. Oravivattanakul, S. Alsallom, F. Yu, X. X. Floden, D. Gostkowski, M. Ahmed, A. Ezzeldin, A. Marouf, H. M. Mansour, O. Y. Fernandez, H. H. | Neurosurgery | 2020 |
Dbs |
| Mortality and complications after emergency laparotomy in patients above 80 years | Aakre, E. K. Ulvik, A. Hufthammer, K. O. Jammer, I. | Acta Anaesthesiol Scand | 2020 |
elderly |
| Evaluation of an emergency department falls pathway for older people: A patient chart review | O' Keeffe A O' Grady S Cronin, F. Dolan, C. O' Hea A O' Shea KL Naughton, C. | Int Emerg Nurs | 2020 | |
| Rapid in-person cognitive screening in the preoperative setting: Test considerations and recommendations from the Society for Perioperative Assessment and Quality Improvement (SPAQI) | Arias, F. Wiggins, M. Urman, R. D. Armstrong, R. Pfeifer, K. Bader, A. M. Libon, D. J. Chopra, A. Price, C. C. | Journal of Clinical Anesthesia | 2020 |
anesthesiology |
| Updated nomenclature of delirium and acute encephalopathy: statement of ten Societies | Slooter, A. J. C. Otte, W. M. Devlin, J. W. Arora, R. C. Bleck, T. P. Claassen, J. Duprey, M. S. Ely, E. W. Kaplan, P. W. Latronico, N. Morandi, A. Neufeld, K. J. Sharshar, T. MacLullich, A. M. J. Stevens, R. D. | Intensive Care Medicine | 2020 |
acute brain disease |
| Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients | Olsen, H. T. Nedergaard, H. K. Strøm, T. Oxlund, J. Wian, K. A. Ytrebø, L. M. Kroken, B. A. Chew, M. Korkmaz, S. Lauridsen, J. T. Toft, P. | The New England journal of medicine | 2020 |
NCT01967680 |
| Ketamine Safety and Use in the Emergency Department for Pain and Agitation/Delirium: A Health System Experience | Mo, H. Campbell, M. J. Fertel, B. S. Lam, S. W. Wells, E. J. Casserly, E. Meldon, S. W. | The western journal of emergency medicine | 2020 |
adult |
| Impact of skeletal muscle mass on postoperative delirium in patients undergoing free flap repair after oral cancer resection | Makiguchi, T. Yamaguchi, T. Nakamura, H. Ogawa, M. Harimoto, N. Shirabe, K. Yokoo, S. | Journal of plastic surgery and hand surgery | 2020 |
adult |
| Identifying delirium in Parkinson disease: A pilot study | Lawson, R. A. Richardson, S. J. Yarnall, A. J. Burn, D. J. Allan, L. M. | International Journal of Geriatric Psychiatry | 2020 |
aged |
| Presurgical cognitive impairment is associated with postoperative delirium and postoperative cognitive dysfunction | Knaak, C. Brockhaus, W. R. Spies, C. Borchers, F. Piper, S. K. Radtke, F. M. Lachmann, G. | Minerva anestesiologica | 2020 |
aged |
| The effects of elective aortic repair, colorectal cancer surgery and subsequent postoperative delirium on long-term quality of life, cognitive functioning and depressive symptoms in older patients | Janssen, T. L. de Vries, J. Lodder, P. Faes, M. C. Ho, G. H. Gobardhan, P. D. van der Laan, L. | Aging & mental health | 2020 |
abdominal aortic aneurysm |
| American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Postoperative Delirium Prevention | Hughes, C. G. Boncyk, C. S. Culley, D. J. Fleisher, L. A. Leung, J. M. McDonagh, D. L. Gan, T. J. McEvoy, M. D. Miller, T. E. | Anesthesia and analgesia | 2020 |
adult |
| Healthcare professionals' reports of cancer pain cues among older people with delirium: a qualitative-quantitative content analysis | Graham, C. A. Chaves, G. Harrison, R. Gauthier, L. R. Nissim, R. Zimmermann, C. Chan, V. Rodin, G. Stevens, B. Gagliese, L. | Journal of pain and symptom management | 2020 |
adult |
| Preoperative Cognitive Abnormality, Intraoperative Electroencephalogram Suppression, and Postoperative Delirium: A Mediation Analysis | Fritz, B. A. King, C. R. Ben Abdallah, A. Lin, N. Mickle, A. M. Budelier, T. P. Oberhaus, J. Park, D. Maybrier, H. R. Wildes, T. S. Avidan, M. S. Apakama, G. Aranake-Chrisinger, A. Bolzenius, J. Burton, J. Cui, V. Emmert, D. A. Goswami, S. Graetz, T. J. G | Anesthesiology | 2020 |
adult |
| Delirium screening and mortality in patients with dementia admitted to acute hospitals | Codling, D. Hood, C. Bassett, P. Smithard, D. Crawford, M. J. | Aging & mental health | 2020 |
aged |
| Do Neuroleptics Still Have a Role in Patients With Delirium? | Nikooie, R. Oh, E. S. Zhang, A. Robinson, K. A. Needham, D. M. | Annals of internal medicine | 2020 |
adult |
| Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery | Li, C. J. Wang, B. J. Mu, D. L. Hu, J. Guo, C. Li, X. Y. Ma, D. Wang, D. X. | British Journal of Surgery | 2020 |
ChiCTRIPR15007654 |
| Risk factors for adverse drug reactions in older inpatients of geriatric wards at admission: Multicenter study | Kojima, T. Matsui, T. Suzuki, Y. Takeya, Y. Tomita, N. Kozaki, K. Kuzuya, M. Rakugi, H. Arai, H. Akishita, M. | Geriatrics and Gerontology International | 2020 |
albumin |
| Real-world effectiveness of ramelteon and suvorexant for delirium prevention in 948 patients with delirium risk factors | Hatta, K. Kishi, Y. Wada, K. Takeuchi, T. Hashimoto, N. Suda, K. Taira, T. Tsuchida, K. Ohmori, T. Akizuki, N. Nishio, Y. Nakanishi, Y. Usui, C. Kurata, A. Horikawa, N. Eguchi, H. Ito, S. Muto, H. Nakamura, H. Uchimura, N. | Journal of Clinical Psychiatry | 2020 |
corticosteroid derivative |
| Independent Association Between Type of Intraoperative Blood Transfusion and Postoperative Delirium After Complex Spinal Fusion for Adult Deformity Correction | Elsamadicy, A. A. Adil, S. M. Charalambous, L. Drysdale, N. Koo, A. B. Lee, M. Kundishora, A. J. Camara-Quintana, J. Kolb, L. Laurans, M. Abbed, K. Karikari, I. O. | Spine | 2020 |
adult |
| Practices related to assessment of sedation, analgesia and delirium among critical care pediatricians in Brazil | Colleti Junior, J. Araujo, O. R. Andrade, A. B. Carvalho, W. B. | Einstein (Sao Paulo, Brazil) | 2020 |
analgesia |
| Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study | Chen, N. Zhou, M. Dong, X. Qu, J. Gong, F. Han, Y. Qiu, Y. Wang, J. Liu, Y. Wei, Y. Xia, J. Yu, T. Zhang, X. Zhang, L. | The Lancet | 2020 |
adult |
| Association between postoperative delirium and mortality in elderly patients undergoing hip fractures surgery: a meta-analysis | Bai, J. Liang, Y. Zhang, P. Liang, X. He, J. Wang, J. Wang, Y. | Osteoporosis International | 2020 |
article |
| Impact of frailty on short-term outcomes in patients undergoing transsphenoidal pituitary surgery | Asemota, A. O. Gallia, G. L. | Journal of Neurosurgery | 2020 |
acute heart infarction |
| Randomised controlled trial to investigate the relationship between mild hypercapnia and cerebral oxygen saturation in patients undergoing major surgery | Wong, C. Churilov, L. Cowie, D. Tan, C. O. Hu, R. Tremewen, D. Pearce, B. Pillai, P. Karalapillai, D. Bellomo, R. Weinberg, L. | BMJ Open | 2020 |
delirium |
| Establishment and validation of a delirium prediction model for neurosurgery patients in intensive care | Wang, J. Ji, Y. Wang, N. Chen, W. Bao, Y. Qin, Q. Ma, C. Xiao, Q. Li, S. | Int J Nurs Pract | 2020 |
delirium |
| Early mobilisation after transfemoral transcatheter aortic valve implantation: results of the MobiTAVI trial | Vendrik, J. Vlastra, W. van Mourik, M. S. Delewi, R. Beijk, M. A. Lemkes, J. Wykrzykowska, J. J. de Winter, R. J. Henriques, J. S. Piek, J. J. Vis, M. M. Koch, K. T. Baan, J., Jr. | Neth Heart J | 2020 |
Ambulation |
| Influence of sedation on delirium recognition in critically ill patients: A multinational cohort study | van den Boogaard, M. Wassenaar, A. van Haren, F. M. P. Slooter, A. J. C. Jorens, P. G. van der Jagt, M. Simons, K. S. Egerod, I. Burry, L. D. Beishuizen, A. Pickkers, P. Devlin, J. W. | Aust Crit Care | 2020 |
Assessment |
| Intraoperative reduction of vasopressors using processed electroencephalographic monitoring in patients undergoing elective cardiac surgery: a randomized clinical trial | Sponholz, C. Schuwirth, C. Koenig, L. Hoyer, H. Coldewey, S. M. Schelenz, C. Doenst, T. Kortgen, A. Bauer, M. | J Clin Monit Comput | 2020 |
Adverse events |
| Enhanced rehabilitation and care models for adults with dementia following hip fracture surgery | Smith, T. O. Gilbert, A. W. Sreekanta, A. Sahota, O. Griffin, X. L. Cross, J. L. Fox, C. Lamb, S. E. | Cochrane Database Syst Rev | 2020 | |
| Prospective Evaluation of Delirium in Geriatric Patients Undergoing Emergency General Surgery | Saljuqi, A. T. Hanna, K. Asmar, S. Tang, A. Zeeshan, M. Gries, L. Ditillo, M. Kulvatunyou, N. Castanon, L. Joseph, B. | J Am Coll Surg | 2020 | |
| Predisposing and Precipitating Factors Associated With Postoperative Delirium in Patients Undergoing Cardiac Surgery at a Veterans Affairs Medical Center: A Pilot Retrospective Analysis | Russell, M. D. Pinkerton, C. Sherman, K. A. Ebert, T. J. Pagel, P. S. | J Cardiothorac Vasc Anesth | 2020 |
Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition |
| Dopaminergic Hyperactivity in Neurological Patients with Delirium | Ramirez-Bermudez, J. Perez-Neri, I. Montes, S. Nente, F. Ramirez-Abascal, M. Carrillo-Mezo, R. Perez-Esparza, R. Soto-Hernandez, J. L. Espinola-Nadurille, M. Bayliss, L. De Jesus Flores Rivera, J. Rios, C. | Arch Med Res | 2020 |
Autoimmune limbic encephalitis |
| Effects of intravenous and mask induction on post-operative emergence delirium in pediatric patients undergoing tonsillectomy with or without adenoidectomy | Peker, K. Polat, R. | Ir J Med Sci | 2020 |
Intravenous induction |
| Safety and Tolerability of Rapid Administration Undiluted Levetiracetam | Morgan, O. Medenwald, B. | Neurocrit Care | 2020 |
Anticonvulsants |
| New use of psychotropic medication after hospitalization among people with dementia | Mollers, T. Perna, L. Stocker, H. Ihle, P. Schubert, I. Schottker, B. Frolich, L. Brenner, H. | Int J Geriatr Psychiatry | 2020 |
claims data |
| A logistic regression analysis comparing minimalistic approach and intubation anaesthesia in patients undergoing transfemoral transcatheter aortic valve replacement | Maier, A. Hammerich, B. Humburger, F. Brieschal, T. Heidt, T. Bothe, W. Schrofel, H. Kaier, K. Zehender, M. Reinohl, J. Bode, C. von Zur Muhlen, C. Stachon, P. | PLoS One | 2020 | |
| Anticipating Postoperative Delirium During Burst Suppression Using Electroencephalography | Ma, O. Crepeau, A. Z. Dutta, A. Bliss, D. | IEEE Trans Biomed Eng | 2020 |
adult |
| Can haloperidol prophylaxis reduce the incidence of delirium in critically ill patients in intensive care units? A systematic review and meta-analysis | Lin, P. Zhang, J. Shi, F. Liang, Z. A. | Heart Lung | 2020 |
Delirium |
| Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit | Li, Y. Ma, J. Jin, Y. Li, N. Zheng, R. Mu, W. Wang, J. Si, J. H. Chen, J. Shang, H. C. | Cochrane Database Syst Rev | 2020 | |
| Delirium prevalence and prevention in patients with acute brain injury: A prospective before-and-after intervention study | Larsen, L. K. Moller, K. Petersen, M. Egerod, I. | Intensive Crit Care Nurs | 2020 |
Brain injuries |
| Postoperative anaemia might be a risk factor for postoperative delirium and prolonged hospital stay: A secondary analysis of a prospective cohort study | Kunz, J. V. Spies, C. D. Bichmann, A. Sieg, M. Mueller, A. | PLoS One | 2020 | |
| Development of a Simple and Practical Delirium Screening Tool for Use in Surgical Wards | Kubota, K. Suzuki, A. Ohde, S. Yamada, U. Fujitani, I. Koitabashi, A. | J Nurs Res | 2020 |
adult |
| Psychometric evaluation of the family caregiver ICU delirium knowledge questionnaire | Krewulak, K. D. Bull, M. J. Ely, E. W. Stelfox, H. T. Fiest, K. M. | BMC Health Serv Res | 2020 |
Critical care |
| The Impact of Acute Kidney Injury in the Perioperative Period on the Incidence of Postoperative Delirium in Patients Undergoing Coronary Artery Bypass Grafting-Observational Cohort Study | Kotfis, K. Slozowska, J. Listewnik, M. Szylinska, A. Rotter, I. | Int J Environ Res Public Health | 2020 |
Aki |
| Delirium point prevalence studies in inpatient settings: A systematic review and meta-analysis | Koirala, B. Hansen, B. R. Hosie, A. Budhathoki, C. Seal, S. Beaman, A. Davidson, P. M. | J Clin Nurs | 2020 |
delirium |
| Validity and Reliability of the Memorial Delirium Assessment Scale-Thai Version (MDAS-T) for Assessment of Delirium in Palliative Care Patients | Klankluang, W. Pukrittayakamee, P. Atsariyasing, W. Siriussawakul, A. Chanthong, P. Tongsai, S. Tayjasanant, S. | Oncologist | 2020 |
Delirium |
| The Impact of an Attending Intensivist on the Clinical Outcomes of Patients Admitted to the Cardiac Surgical Intensive Care Unit after Coronary Artery Bypass Grafting | Kim, D. J. Sohn, B. Kim, H. Chang, H. W. Lee, J. H. Kim, J. S. Lim, C. Park, K. H. | Korean J Thorac Cardiovasc Surg | 2020 |
Coronary artery bypass grafting |
| Working Collaboratively: Outcomes of Geriatrician Input in Older Patients Undergoing Emergency Laparotomy in a District General Hospital | Khan, K. A. Subramanian, T. Richters, M. Mubarik, A. Saad Abdalla Al-Zawi, A. Thorn, C. C. Chalstrey, S. Gunasekera, S. | Cureus | 2020 |
ageing & frailty |
| Postoperative delirium: the findings from a multidisciplinary survey | Jin, Z. Rahman, A. Pattnaik, S. Smith, M. | Psychogeriatrics | 2020 |
education |
| Postoperative delirium after reconstructive surgery for oral tumor: a retrospective clinical study | Ishibashi-Kanno, N. Takaoka, S. Nagai, H. Okubo-Sato, M. Fukuzawa, S. Uchida, F. Yamagata, K. Yanagawa, T. Bukawa, H. | Int J Oral Maxillofac Surg | 2020 |
Delirium |
| Joining Forces against Delirium - From Organ-System Care to Whole-Human Care | Inouye, S. K. | N Engl J Med | 2020 |
Aged |
| Incidence of and risk factors for postoperative delirium in older adult patients undergoing noncardiac surgery: a prospective study | Iamaroon, A. Wongviriyawong, T. Sura-Arunsumrit, P. Wiwatnodom, N. Rewuri, N. Chaiwat, O. | BMC Geriatr | 2020 |
Collaborative approach |
| Delirium misdiagnosis risk in psychiatry: a machine learning-logistic regression predictive algorithm | Hercus, C. Hudaib, A. R. | BMC Health Serv Res | 2020 |
Delirium |