What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Prevention of dexmedetomidine on postoperative delirium and early postoperative cognitive dysfunction in elderly patients undergoing hepatic lobectomy
- Authors
- Tang, Y. Wang, Y. Kong, G. Zhao, Y. Wei, L. Liu, J.
- Year
- 2022
- Journal
- Zhong Nan Da Xue Xue Bao Yi Xue Ban
- Abstract
OBJECTIVES: Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are common operative neurocognitive disorders, which places a heavy burden on patients, families and society. Therefore, it is very important to search for preventive drugs. Previous studies have demonstrated that perioperative use of dexmedetomidine resulted in a decrease the incidence of POD and POCD. But the specific effect of dexmedetomidine on elderly patients undergoing hepatic lobectomy and its potential mechanism are not clear. This study aims to evaluate the efficacy of intraoperative use of dexmedetomidine on preventing POD and POCD in elderly patients undergoing hepatic lobectomy and the influence on the balance between proinflammation and anti-inflammation. METHODS: This trial was designed as a single-center, prospective, randomized, controlled study. One hundred and twenty hospitalized patients from January 2019 to December 2020, aged 60-80 years old with American Society of Anesthesiologists (ASA) II-III and scheduled for hepatic lobectomy, were randomly allocated into 3 groups (n=40) using a random number table: A C group, a Dex1 group, and a Dex2 group. After anesthesia induction, saline in the C group, dexmedetomidine [0.3 μg/(kg·h)] in the Dex1 group, and dexmedetomidine [0.6 μg/(kg·h)] in the Dex2 group were infused until the end of operation. The incidences of hypotension and bradycardia were compared among the 3 groups. Confusion Assessment Method (CAM) for assessing POD and Mini Mental State Examination (MMSE) for evaluating POCD were recorded and venous blood samples were obtained for the determination of neuron specific enolase (NSE), TNF-α, IL-1β, and IL-10 at the different time below: the time before anesthesia (T0), and the first day (T1), the third day (T2), the fifth day (T3), and the seventh day (T4) after operation. RESULTS: Compared with the C group, the incidences of bradycardia in the Dex1 group or the Dex2 group increased (both P<0.05) and there was no difference in hypotension in the Dex1 group or the Dex2 group (both P>0.05). The incidences of POD in the C group, the Dex1 group, and the Dex2 group were 22.5%, 5.0%, and 7.5%, respectively. The incidences of POD in the Dex1 group or the Dex2 group declined significantly as compared to the C group (both P<0.05). However, there is no difference in the incidence of POD between the Dex1 group and the Dex2 group (P>0.05). The incidences of POCD in the C group, the Dex1 group, and the Dex2 group were 30.0%, 12.5%, and 10.0%, respectively. The incidences of POCD in the Dex1 group and the Dex2 group declined significantly as compared to the C group (both P<0.05). And no obvious difference was seen in the incidence of POCD in the Dex1 group and the Dex2 group (P>0.05). Compared with the C group, the level of TNF-α and IL-1β decreased and the level of IL-10 increased at each time points (from T1 to T4) in the Dex1 group and the Dex2 group (all P<0.05). Compared with the Dex1 group, the level of IL-1β at T2 and IL-10 from T1 to T3 elevated in the Dex2 group (all P<0.05). Compared with the T0, the concentrations of NSE in C group at each time points (from T1 to T4) and in the Dex1 group and the Dex2 group from T1 to T3 increased (all P<0.05). Compared with the C group, the level of NSE decreased from T1 to T4 in the Dex1 group and the Dex2 group (all P<0.05). CONCLUSIONS: Intraoperative dexmedetomidine infusion can reduce the incidence of POCD and POD in elderly patients undergoing hepatic lobectomy, and the protective mechanism appears to involve the down-regulation of TNF-α and IL-1β and upregulation of IL-10 expression, which lead to rebalance between proinflammation and anti-inflammation.
- PMID
- Keywords
Aged
Aged, 80 and over
Bradycardia
*Cognitive Dysfunction/etiology/prevention & control
*Delirium/drug therapy/epidemiology/prevention & control
*Dexmedetomidine/therapeutic use
Humans
*Hypotension/complications/drug therapy
Interleukin-10
Middle Aged
*Postoperative Cognitive Complications/prevention & control
Postoperative Complications/epidemiology
Prospective Studies
Tumor Necrosis Factor-alpha
dexmedetomidine
elderly patients
hepatic lobectomy
postoperative cognitive dysfunction
postoperative delirium
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients | Helms, J. Kremer, S. Merdji, H. Schenck, M. Severac, F. Clere-Jehl, R. Studer, A. Radosavljevic, M. Kummerlen, C. Monnier, A. Boulay, C. Fafi-Kremer, S. Castelain, V. Ohana, M. Anheim, M. Schneider, F. Meziani, F. | Crit Care | 2020 |
Aged |
| Detecting Delirium: A Systematic Review of Identification Instruments for Non-ICU Settings | Helfand, B. K. I. D'Aquila, M. L. Tabloski, P. Erickson, K. Yue, J. Fong, T. G. Hshieh, T. T. Metzger, E. D. Schmitt, E. M. Boudreaux, E. D. Inouye, S. K. Jones, R. N. | J Am Geriatr Soc | 2020 |
delirium |
| Radiological, Chemical and Pharmacological Cholinergic System Parameters and Neurocognitive Disorders in Older Pre-Surgical Adults | Heinrich, M. Müller, A. Lammers-Lietz, F. Borchers, F. Mörgeli, R. Kruppa, J. Zacharias, N. Winterer, G. Slooter, A. J. C. Spies, C. D. | J Gerontol A Biol Sci Med Sci | 2020 |
Anticholinergic Medication |
| Dexmedetomidine for the prevention of postoperative delirium in patients after intracranial operation for brain tumours (DEPOD study): a study protocol and statistical plan for a multicentre randomised controlled trial | He, X. Cheng, K. M. Zhang, L. Gu, H. Qu, X. Xu, Y. Ma, P. Zhou, J. X. | BMJ Open | 2020 |
adult intensive & critical care |
| Association between increased neutrophil-to-lymphocyte ratio and postoperative delirium in elderly patients with total hip arthroplasty for hip fracture | He, R. Wang, F. Shen, H. Zeng, Y. LijuanZhang | BMC Psychiatry | 2020 |
Elderly patients |
| The accuracy of delirium assessment by cardiologists treating heart failure inpatients: a single center retrospective survey | Hayashi, A. Kobayashi, S. Matsui, K. Akaho, R. Nishimura, K. | Biopsychosoc Med | 2020 |
Consultation-liaison psychiatry |
| Rates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents and beta-blockers: An electronic health records network study | Harrison, P. J. Luciano, S. Colbourne, L. | J Psychopharmacol | 2020 |
Delirium |
| Managing delirium in terminally ill patients: perspective of palliative care nurse specialists | Harris, C. Spiller, J. Finucane, A. | Br J Community Nurs | 2020 |
Clinical nurse specialists |
| Metabolomic and Lipidomic Profiling of Preoperative CSF in Elderly Hip Fracture Patients With Postoperative Delirium | Han, Y. Zhang, W. Liu, J. Song, Y. Liu, T. Li, Z. Wang, X. Yang, N. Li, Y. Han, D. Mi, X. Zhou, Y. Li, M. Guo, X. Zhong, L. Wang, G. Yuan, Y. | Front Aging Neurosci | 2020 |
cerebrospinal fluid |
| Increased Association With Malnutrition and Malnourishment in Older Adults Admitted With Hip Fractures Who Have Cognitive Impairment and Delirium, as Assessed by 4AT | Han, T. S. Lisk, R. Osmani, A. Sharmin, R. El Gammel, S. Yeong, K. Fluck, D. Fry, C. H. | Nutr Clin Pract | 2020 |
cognitive dysfunction |
| Delirium During Recovery in Patients With Severe COVID-19: Two Case Reports | Han, D. Wang, C. Feng, X. Wu, J. | Front Med (Lausanne) | 2020 |
Covid-19 |
| Mannitol Is Associated with Less Postoperative Delirium after Aortic Valve Surgery in Patients Treated with Bretschneider Cardioplegia | Hamiko, M. Charitos, E. I. Velten, M. Hilbert, T. Putensen, C. Treede, H. Duerr, G. D. | Thoracic and Cardiovascular Surgeon | 2020 |
adult |
| Comparison of the prevalence and associated factors of hyperactive delirium in advanced cancer patients between inpatient palliative care and palliative home care | Hamano, J. Mori, M. Ozawa, T. Sasaki, J. Kawahara, M. Nakamura, A. Hashimoto, K. Hisajima, K. Koga, T. Goto, K. Fukumoto, K. Morimoto, Y. Goshima, M. Sekimoto, G. Baba, M. Oya, K. Matsunuma, R. Azuma, Y. Imai, K. Morita, T. Shinjo, T. | Cancer Med | 2020 |
advanced cancer patients |
| Treatment of delirium in palliative patients - role of neuroleptics | Hainsch-Müller, I. Aulmann, C. Djukic, I. | Internistische Praxis | 2020 |
neuroleptic agent |
| Identifying Delirium Early after Stroke: A New Prediction Tool for the Intensive Care Unit | Haight, T. N. Marsh, E. B. | J Stroke Cerebrovasc Dis | 2020 |
Adult |
| Socioeconomic Factors and Intensive Care Unit-Related Cognitive Impairment | Haddad, D. N. Mart, M. F. Wang, L. Lindsell, C. J. Raman, R. Nordness, M. F. Sharp, K. W. Pandharipande, P. P. Girard, T. D. Ely, E. W. Patel, M. B. | Ann Surg | 2020 |
Aged |
| Opioid use is Associated with ICU Delirium in Mechanically Ventilated Children | Gupta, N. Woolley, A. Talathi, S. Davlyatov, G. Colston, C. Hayes, L. | J Crit Care Med (Targu Mures) | 2020 |
intensive care unit |
| A two-year multicenter point prevalence study of older patients with hip fractures admitted to rehabilitation units in Italy | Guerzoni, V. Lanzoni, A. Pozzi, C. Paci, M. Gatti, R. Benedetti, M. G. Gentile, S. Trabucchi, M. Bellelli, G. Morandi, A. | Eur Geriatr Med | 2020 |
Delirium |
| Preoperative Cognitive Impairment and Postoperative Delirium Predict Decline in Activities of Daily Living after Cardiac Surgery-A Prospective, Observational Cohort Study | Guenther, U. Hoffmann, F. Dewald, O. Malek, R. Brimmers, K. Theuerkauf, N. Putensen, C. Popp, J. | Geriatrics (Basel) | 2020 |
activity of daily living |
| Risk Factors for Delirium and Cognitive Decline Following Coronary Artery Bypass Grafting Surgery: A Systematic Review and Meta-Analysis | Greaves, D. Psaltis, P. J. Davis, D. H. J. Ross, T. J. Ghezzi, E. S. Lampit, A. Smith, A. E. Keage, H. A. D. | J Am Heart Assoc | 2020 |
cognitive decline |
| Prevalence and risk factors of delirium in the intensive care unit: An observational study | Gravante, F. Giannarelli, D. Pucci, A. Gagliardi, A. M. Mitello, L. Montagna, A. Latina, R. | Nurs Crit Care | 2020 |
delirium |
| Health Care Professionals' Reports of Cancer Pain Cues Among Older People With Delirium: A Qualitative-Quantitative Content Analysis | Graham, C. A. Chaves, G. Harrison, R. Gauthier, L. R. Nissim, R. Zimmermann, C. Chan, V. Rodin, G. Stevens, B. Gagliese, L. | J Pain Symptom Manage | 2020 |
Cancer pain |
| Benzodiazepinics and the treatment of delirium: a literature review | Gonçalves, O. H. P. Pellissari, G. M. Paiva, H. S. | Rev Assoc Med Bras (1992) | 2020 |
Benzodiazepines/therapeutic use |
| Analysis of Delirium from the Dynamic Symptoms Model: A Literature Review | Gómez Tovar, L. O. Henao Castaño, A. M. | Critical Care Nursing Quarterly | 2020 |
conceptual framework |
| Association of delirium with long-term cognitive decline: A meta-analysis | Goldberg, T. E. Chen, C. Wang, Y. Jung, E. Swanson, A. Ing, C. Garcia, P. S. Whittington, R. A. Moitra, V. | JAMA Neurology | 2020 |
article |
| Functional and cognitive decline in older delirious adults after an emergency department visit | Giroux, M. Émond, M. Nadeau, A. Boucher, V. Carmichael, P. H. Voyer, P. Pelletier, M. Gouin, É Daoust, R. Berthelot, S. Lamontagne, M. E. Morin, M. Lemire, S. Sirois, M. J. | Age Ageing | 2020 |
cognitive decline |
| The prevalence rates and sequelae of delirium at age older than 90 years | Gehrke, S. Bode, L. Seiler, A. Ernst, J. von Känel, R. Boettger, S. | Palliat Support Care | 2020 |
Delirium |
| Complications of LVAD utilization in older adults | Gazda, A. J. Kwak, M. J. Akkanti, B. Nathan, S. Kumar, S. de Armas, I. S. Baer, P. Patel, B. Kar, B. Gregoric, I. D. | Heart and Lung | 2020 |
aged |
| Consolidated framework for advancing implementation science for the implementation process and adherence assessment of a non-pharmacological delirium prevention program | Garrido, M. A. Alvarez, E. A. Ponce, D. P. Salech, F. Tobar, D. I. Tobar, E. A. | Int J Geriatr Psychiatry | 2020 |
Cfir |
| Delirium and Adverse Outcomes in Hospitalized Patients with COVID-19 | Garcez, F. B. Aliberti, M. J. R. Poco, P. C. E. Hiratsuka, M. Takahashi, S. D. F. Coelho, V. A. Salotto, D. B. Moreira, M. L. V. Jacob-Filho, W. Avelino-Silva, T. J. | Journal of the American Geriatrics Society | 2020 |
mechanical ventilator |
| The Effects of Melatonin Supplementation on Sleep Quality and Assessment of the Serum Melatonin in ICU Patients: A Randomized Controlled Trial | Gandolfi, J. V. Di Bernardo, A. P. A. Chanes, D. A. V. Martin, D. F. Joles, V. B. Amendola, C. P. Sanches, L. C. Ciorlia, G. L. Lobo, S. M. | Critical care medicine | 2020 |
adult |
| Atypical presentation of COVID-19 in hospitalised older adults | Gan, J. M. Kho, J. Akhunbay-Fudge, M. Choo, H. M. Wright, M. Batt, F. Mandal, A. K. J. Chauhan, R. Missouris, C. G. | Ir J Med Sci | 2020 |
Atypical symptoms |
| Delirium in elderly patients: Prospective prevalence across hospital services | Fuchs, S. Bode, L. Ernst, J. Marquetand, J. von Känel, R. Böttger, S. | Gen Hosp Psychiatry | 2020 |
>65 years |
| Ascertainment of delirium status using natural language processing from electronic health records | Fu, S. Lopes, G. S. Pagali, S. R. Thorsteinsdottir, B. LeBrasseur, N. K. Wen, A. Liu, H. Rocca, W. A. Olson, J. E. St Sauver, J. Sohn, S. | J Gerontol A Biol Sci Med Sci | 2020 |
confusion assessment method |
| A Multi-Phase Quality Improvement Initiative for the Treatment of Active Delirium in Older Persons | Friedman, J. I. Li, L. Kirpalani, S. Zhong, X. Freeman, R. Cheng, Y. T. Alfonso, F. L. McAlpine, G. Vakil, A. Macon, B. Francaviglia, P. Cassara, M. LoPachin, V. Reina, K. Davis, K. Reich, D. Craven, C. K. Mazumdar, M. Siu, A. L. | J Am Geriatr Soc | 2020 |
Confusion Assessment Method |
| Delirium diagnostic tool-provisional (DDT-Pro) scores in delirium, subsyndromal delirium and no delirium | Franco, J. G. Trzepacz, P. T. Sepúlveda, E. Ocampo, M. V. Velásquez-Tirado, J. D. Zaraza, D. R. Restrepo, C. Giraldo, A. M. Serna, P. A. Zuluaga, A. López, C. | Gen Hosp Psychiatry | 2020 |
Cluster analysis |
| A multimodal sevoflurane-based sedation regimen in combination with targeted temperature management in post-cardiac arrest patients reduces the incidence of delirium: An observational propensity score-matched study | Foudraine, N. A. Algargoush, A. van Osch, F. H. Bos, A. T. | Resuscitation | 2020 |
Cardiac arrest |
| Association of Plasma Neurofilament Light with Postoperative Delirium | Fong, T. G. Vasunilashorn, S. M. Ngo, L. Libermann, T. A. Dillon, S. T. Schmitt, E. M. Pascual-Leone, A. Arnold, S. E. Jones, R. N. Marcantonio, E. R. Inouye, S. K. | Ann Neurol | 2020 |
Aged |
| Course and Recognition of Poststroke Delirium: A Prospective Noninferiority Trial of Delirium Screening Tools | Fleischmann, R. Warwas, S. Andrasch, T. Kunz, R. Witt, C. Mengel, A. von Sarnowski, B. | Stroke | 2020 |
delirium |
| The collateral history: an overlooked core clinical skill | Fitzpatrick, D. Doyle, K. Finn, G. Gallagher, P. | Eur Geriatr Med | 2020 |
Clinical training |
| Management of delirium superimposed on dementia in a dementia service | FitzGerald, J. Yan, M. Bandecar, A. Ratnasabapathy, V. Rubinsztein, J. Hatfield, C. Ruhi, S. | Progress in Neurology and Psychiatry | 2020 |
adult |
| Partnering With Family Members to Detect Delirium in Critically Ill Patients | Fiest, K. M. Krewulak, K. D. Ely, E. W. Davidson, J. E. Ismail, Z. Sept, B. G. Stelfox, H. T. | Crit Care Med | 2020 |
adult |
| The correlation of intraoperative hypotension and postoperative cognitive impairment: a meta-analysis of randomized controlled trials | Feng, X. Hu, J. Hua, F. Zhang, J. Zhang, L. Xu, G. | BMC Anesthesiol | 2020 |
Intraoperative hypotension |
| The effect of joints range of motion exercises on delirium prevention in patients admitted to intensive care units | Farzammanesh, A. Jahani, S. Rashidi, M. Maraghi, E. Ravanbakhsh, M. | International Journal of Pharmaceutical and Phytopharmacological Research | 2020 |
IRCT20180114038362N1 |
| Sleep and Delirium in Older Adults | Farasat, S. Dorsch, J. J. Pearce, A. K. Moore, A. A. Martin, J. L. Malhotra, A. Kamdar, B. B. | Curr Sleep Med Rep | 2020 |
Acetylcholine |
| Association between use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and postoperative delirium | Farag, E. Farag, E. Liang, C. Liang, C. Mascha, E. J. Mascha, E. J. Argalious, M. Y. Ezell, J. Maheshwari, K. Esa, W. A. S. Troianos, C. A. Sessler, D. I. | Anesthesiology | 2020 |
adult |
| Delirium in cardiology: An old problem, a new emergency | Falsini, G. Romanelli, S. Insana, L. Frongillo, D. Grotti, S. Angioli, P. Ducci, K. Liistro, F. Calchetti, B. Rossi, R. Bolognese, L. | Giornale Italiano di Cardiologia | 2020 |
attitude to illness |
| Surveying work-as-done in post-operative delirium risk factors collection and diagnosis monitoring | Falegnami, A. Patriarca, R. Costantino, F. Di Gravio, G. Bilotta, F. | Appl Ergon | 2020 |
RiskSOAP |
| Psychiatric disorders, delirium and mortality in patients referred for consultation in a burn center: A four-year retrospective study | Erdoğan, E. Delibaş, D. H. | Medical Journal of Bakirkoy | 2020 |
antidepressant agent |
| Delirium in Older People with COVID-19: Clinical Scenario and Literature Review | Emmerton, D. Abdelhafiz, A. | SN Compr Clin Med | 2020 |
Covid-19 |
| "It should not be that difficult to manage a condition that is so frequent": A qualitative study on hospital nurses' experience of delirium guidelines | Emme, C. | J Clin Nurs | 2020 |
Adult |
| Where should patients with or at risk of delirium be treated in an acute care system? Comparing the rates of delirium in patients receiving usual care versus alternative care: a systematic review and meta-analysis | Ekeozor, C. U. Jeyaruban, D. Lasserson, D. | Int J Clin Pract | 2020 |
Acute care |
| Effect of General Versus Spinal Anesthesia on Postoperative Delirium and Early Cognitive Dysfunction in Elderly Patients | Ehsani, R. Djalali Motlagh, S. Zaman, B. Sehat Kashani, S. Ghodraty, M. R. | Anesth Pain Med | 2020 |
Delirium |
| Anticholinergic Drug Burden and Delirium: A Systematic Review | Egberts, A. Moreno-Gonzalez, R. Alan, H. Ziere, G. Mattace-Raso, F. U. S. | Journal of the American Medical Directors Association | 2020 |
adult |
| Antipsychotics and Lorazepam During Delirium: Are We Harming Older Patients? A Real-Life Data Study | Egberts, A. Alan, H. Ziere, G. Mattace-Raso, F. U. S. | Drugs and Aging | 2020 |
acutely ill patient |
| Delirium in Internal Medicine Departments in a Tertiary Hospital in Israel: Occurrence, Detection Rates, Risk Factors, and Outcomes | Efraim, N. T. Zikrin, E. Shacham, D. Katz, D. Makulin, E. Barski, L. Zeller, L. Bartal, C. Freud, T. Lebedinski, S. Press, Y. | Front Med (Lausanne) | 2020 |
delirium |
| Development and validation of an aetiology in delirium diagnostic support tool | Eeles, E. Huang, L. Dakin, L. Ling, C. Dunn, E. Fraser, J. Dissanayaka, N. N. | Age Ageing | 2020 |
aetiology |
| Association of Geriatric Events With Perioperative Outcomes After Elective Inpatient Surgery | Dworsky, J. Q. Shellito, A. D. Childers, C. P. Copeland, T. P. Maggard-Gibbons, M. Tan, H. J. Saliba, D. Russell, M. M. | J Surg Res | 2020 |
Elderly |
| Is there an association between subjective sleep quality and daily delirium occurrence in critically ill adults? A post hoc analysis of a randomised controlled trial | Duprey, M. S. Devlin, J. W. Skrobik, Y. | BMJ Open Respir Res | 2020 |
clinical epidemiology |
| Approaches to Optimize Medication Data Analysis in Clinical Cohort Studies | Duprey, M. S. Devlin, J. W. Briesacher, B. A. Travison, T. G. Griffith, J. L. Inouye, S. K. | J Am Geriatr Soc | 2020 |
delirium |
| Delirium definition influences prediction of functional survival in patients one-year postcardiac surgery | Dubiel, C. Hiebert, B. M. Stammers, A. N. Sanjanwala, R. M. Tangri, N. Singal, R. K. Manji, R. A. Rudolph, J. L. Arora, R. C. | J Thorac Cardiovasc Surg | 2020 |
cardiac surgery |
| Prevalence and outcome of delirium among acute general medical inpatients in Cape Town, South Africa | Du Plooy, N. Day, C. Manning, K. Abdullah, F. James, K. Grace, L. Vorajee, N. April, C. Peter, J. Peter, J. Raubenheimer, P. J. | South African Medical Journal | 2020 |
indwelling urinary catheter |
| Delirium Post-Stroke-Influence on Post-Stroke Dementia (Research Study-Part of the PROPOLIS Study) | Droś, J. Kowalska, K. Pasińska, P. Szyper-Maciejowska, A. Gorzkowska, A. Klimkowicz-Mrowiec, A. | J Clin Med | 2020 |
cognitive impairment |
| Providing Evidence-Based Care, Day and Night: A Quality Improvement Initiative to Improve Intensive Care Unit Patient Sleep Quality | Douglas, S. L. Hobbs, H. A. Sibley, S. R. Digby, G. C. | J Intensive Care Med | 2020 |
critical care |
| An Implementation-Effectiveness Study of a Perioperative Delirium Prevention Initiative for Older Adults | Donovan, A. L. Braehler, M. R. Robinowitz, D. L. Lazar, A. A. Finlayson, E. Rogers, S. Douglas, V. C. Whitlock, E. L. | Anesth Analg | 2020 |
Aged |
| Effectiveness of a multidisciplinary comprehensive intervention model based on the Hospital Elderly Life Program to prevent delirium in patients with severe acute pancreatitis | Dong, Z. Song, J. Ge, M. Lin, C. Zhang, J. Chen, J. Wu, Y. | Ann Palliat Med | 2020 |
Pancreatitis |
| Does Preoperative Comprehensive Geriatric Assessment and Frailty Predict Postoperative Complications? | Dogrul, R. T. Dogrul, A. B. Konan, A. Caglar, O. Sumer, F. Caliskan, H. Kizilarslanoglu, M. C. Kilic, M. K. Balci, C. Arik, G. Aycicek, G. S. Ozsurekci, C. Halil, M. Cankurtaran, M. Yavuz, B. B. | World journal of surgery | 2020 |
aged |
| Preoperative Acute Pain Is Associated with Postoperative Delirium | Ding, X. Gao, X. Chen, Q. Jiang, X. Li, Y. Xu, J. Qin, G. Lu, S. Huang, D. | Pain Med | 2020 |
C-Reactive Protein |
| Effects of electroencephalography and regional cerebral oxygen saturation monitoring on perioperative neurocognitive disorders: a systematic review and meta-analysis | Ding, L. Chen, D. X. Li, Q. | BMC Anesthesiol | 2020 |
Electroencephalography |
| The Addition of Intravenous Propofol and Ketorolac to a Sevoflurane Anesthetic Lessens Emergence Agitation in Children Having Bilateral Myringotomy with Tympanostomy Tube Insertion: A Prospective Observational Study | d'Eon, B. Hackmann, T. Wright, A. S. | Children (Basel) | 2020 |
emergence agitation |
| Preoperative Nutritional Status and Risk for Subsyndromal Delirium in Older Adults Following Joint Replacement Surgery | Denny, D. L. Trotter, T. Lindseth, G. | Orthopedic nursing | 2020 |
aged |
| Non-pharmacological interventions to reduce the incidence and duration of delirium in critically ill patients: A systematic review and network meta-analysis | Deng, L. X. Cao, L. Zhang, L. N. Peng, X. B. Zhang, L. | J Crit Care | 2020 |
Delirium prevention |
| Multidimensional nursing interventions effect on delirium and hospital admission duration | Dehghani, S. Asadizaker, M. Adineh, M. Maraghi, E. Akbarian, S. Ramezani, B. | International Journal of Pharmaceutical and Phytopharmacological Research | 2020 |
IRCT20181005041233N1 |
| Effects of pain, sedation and delirium monitoring on clinical and economic outcome: A retrospective study | Deffland, M. Spies, C. Weiss, B. Keller, N. Jenny, M. Kruppa, J. Balzer, F. | PLoS ONE | 2020 |
NCT02265263 |
| The association of post-operative delirium with health-related quality of life and mortality after lung transplantation | DeBolt, C. Gao, Y. Sutter, N. Soong, A. Trinh, B. N. Kukreja, J. Kleinhenz, M. Venado, A. Leard, L. E. Hays, S. Greenland, J. R. Shah, R. J. Douglas, V. Kolaitis, N. A. Diamond, J. M. Smith, P. J. Singer, J. P. | American Journal of Respiratory and Critical Care Medicine | 2020 |
adult |
| Development and validation of a delirium risk prediction preoperative model for cardiac surgery patients (DELIPRECAS): An observational multicentre study | de la Varga-Martínez, O. Gómez-Pesquera, E. Muñoz-Moreno, M. F. Marcos-Vidal, J. M. López-Gómez, A. Rodenas-Gómez, F. Ramasco, F. Álvarez-Refojo, F. Tamayo, E. Gómez-Sánchez, E. | J Clin Anesth | 2020 |
Cardiac surgery |
| The Effect of Multiple Assessments on Delirium Detection: a Pilot Study | de Freitas, S. A. Wong, E. Lee, J. Y. Reppas-Rindlisbacher, C. Gabor, C. Curkovic, A. Patterson, C. J. | Can Geriatr J | 2020 |
3d-cam |
| Delirium Detection Based on the Clinical Experience of Pediatric Intensivists | de Castro, R. E. V. de Magalhães-Barbosa, M. C. Cunha, Ajlad Cheniaux, E. Prata-Barbosa, A. | Pediatr Crit Care Med | 2020 | |
| Kidney Function Modifies the Effect of Intraoperative Opioid Dosage on Postoperative Delirium | Davani, A. B. Snyder, S. H. Oh, E. S. Mears, S. C. Crews, D. C. Wang, N. Y. Sieber, F. E. | J Am Geriatr Soc | 2020 |
analgesics, opioids |
| One-year mortality rate after fragility hip fractures and associated risk in Nan, Thailand | Daraphongsataporn, N. Saloa, S. Sriruanthong, K. Philawuth, N. Waiwattana, K. Chonyuen, P. Pimolbutr, K. Sucharitpongpan, W. | Osteoporosis and Sarcopenia | 2020 |
aged |
| Abnormal Sleep, Circadian Rhythm Disruption, and Delirium in the ICU: Are They Related? | Daou, M. Telias, I. Younes, M. Brochard, L. Wilcox, M. E. | Front Neurol | 2020 |
ICU acquired delirium |
| Delirium prevention and treatment in the emergency department (ED): a systematic review protocol | Dahlstrom, E. B. Han, J. H. Healy, H. Kennedy, M. Arendts, G. Lee, J. Carpenter, C. Lee, S. | BMJ Open | 2020 |
accident & emergency medicine |
| Pathomechanisms of Non-Traumatic Acute Brain Injury in Critically Ill Patients | Dabrowski, W. Siwicka-Gieroba, D. Gasinska-Blotniak, M. Zaid, S. Jezierska, M. Pakulski, C. Williams Roberson, S. Wesley Ely, E. Kotfis, K. | Medicina (Kaunas) | 2020 |
critical illness |
| Low molecular weight heparin in COVID-19 patients prevents delirium and shortens hospitalization | D’Ardes, D. Carrarini, C. Russo, M. Dono, F. Speranza, R. Digiovanni, A. Martinotti, G. Di Iorio, A. Onofrj, M. Cipollone, F. Bonanni, L. | Neurological Sciences | 2020 |
adult |
| Postoperative delirium: why, what, and how to confront it at your institution | Curtis, M. S. Forman, N. A. Donovan, A. L. Whitlock, E. L. | Curr Opin Anaesthesiol | 2020 |
Aged |
| Delirium due to intoxication with quetiapine: A systematic literature review | Crombez, S. van Den Wijngaert, V. Demyttenaere, K. de Fruyt, J. | Tijdschrift voor Psychiatrie | 2020 |
physostigmine |
| Postoperative delirium in patients with head and neck oral cancer in the West of Scotland | Crawford, J. E. Zubair, F. Baniulyte, G. Wales, C. J. Ansell, M. Thomson, E. Hislop, S. MacIver, C. Devine, J. McCaul, J. Young, D. McMahon, J. | Br J Oral Maxillofac Surg | 2020 |
Eras |
| Diagnosis, prevention, and management of delirium in the intensive cardiac care unit | Cortés-Beringola, A. Vicent, L. Martín-Asenjo, R. Puerto, E. Domínguez-Pérez, L. Maruri, R. Moreno, G. Vidán, M. T. Fernando, Arribas Bueno, H. | Am Heart J | 2020 | |
| Serum DBI and biomarkers of neuroinflammation in Alzheimer's disease and delirium | Conti, E. Andreoni, S. Tomaselli, D. Storti, B. Brovelli, F. Acampora, R. Da Re, F. Appollonio, I. Ferrarese, C. Tremolizzo, L. | Neurol Sci | 2020 |
Alzheimer’s disease |
| A complication of coronavirus disease 2019: delirium | Cipriani, G. Danti, S. Nuti, A. Carlesi, C. Lucetti, C. Di Fiorino, M. | Acta Neurol Belg | 2020 |
Betacoronavirus |
| Post-operative delirium and cognitive decline in kidney transplantation | Chu, N. M. Chen, X. Segev, D. L. McAdams-DeMarco, M. | Journal of the American Society of Nephrology | 2020 |
adult |
| Vitamin D and Delirium in Older Adults: A Case-Control Study in Geriatric Acute Care Unit | Chouët, J. Sacco, G. Karras, S. N. Llewellyn, D. J. Sánchez-Rodríguez, D. Annweiler, C. | Front Neurol | 2020 |
cognition |
| Risk factors for postoperative delirium in elderly patients after spinal fusion surgery | Choi, S. Jung, I. Yoo, B. Lee, S. Kim, M. C. | Anesth Pain Med (Seoul) | 2020 |
Aged |
| Multimodal Education Program to Improve Nurses' Knowledge and Confidence on Delirium Recognition in a Surgical-Trauma Intermediate-Care Setting | Choi, M. DeGennaro, R. Blevins, C. | Journal of doctoral nursing practice | 2020 |
adult |
| Development and validation of delirium prediction model for critically ill adults parameterized to ICU admission acuity | Cherak, S. J. Soo, A. Brown, K. N. Ely, E. W. Stelfox, H. T. Fiest, K. M. | PLoS One | 2020 |
Apache |
| Association of Glucose Variability and ICU Delirium of Patients after Liver Transplantation | Cheng, J. L. Dong, M. L. Zhang, Z. W. Liao, X. L. Yang, J. Y. Kang, Y. | Journal of Sichuan University. Medical science edition | 2020 |
adverse event |
| Modified Frailty Index Independently Predicts Postoperative Delirium and Delayed Neurocognitive Recovery After Elective Total Joint Arthroplasty | Chen, Y. Qin, J. | J Arthroplasty | 2020 |
delayed neurocognitive recovery |
| Risk predictive models for delirium in the intensive care unit: a systematic review and meta-analysis | Chen, X. Lao, Y. Zhang, Y. Qiao, L. Zhuang, Y. | Ann Palliat Med | 2020 |
Delirium |
| Diagnostic accuracy of the CAM-ICU and ICDSC in detecting intensive care unit delirium: A bivariate meta-analysis | Chen, T. J. Chung, Y. W. Chang, H. C. R. Chen, P. Y. Wu, C. R. Hsieh, S. H. Chiu, H. Y. | International journal of nursing studies | 2020 |
adult |
| Atypical Sleep and Postoperative Delirium in the Cardiothoracic Surgical Intensive Care Unit: A Pilot Prospective Study | Chen, Q. Peng, Y. Lin, Y. Li, S. Huang, X. Chen, L. W. | Nat Sci Sleep | 2020 |
atypical sleep |