What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients (Review)
- Authors
- Burton JK, Craig LE, Yong SQ, Siddiqi N, Teale EA, Woodhouse R, Barugh AJ, Shepherd AM, Brunton A, Freeman SC, Sutton AJ, Quinn TJ
- Year
- 2021
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is an acute neuropsychological disorder that is common in hospitalised patients. It can be distressing to patients and carers and it is associated with serious adverse outcomes. Treatment options for established delirium are limited and so prevention of delirium is desirable. Non-pharmacological interventions are thought to be important in delirium prevention. OBJECTIVES: To assess the effectiveness of non-pharmacological interventions designed to prevent delirium in hospitalised patients outside intensive care units (ICU).
Search methods: We searched ALOIS, the specialised register of the Cochrane Dementia and Cognitive Improvement Group, with additional searches conducted in MEDLINE, Embase, PsycINFO, CINAHL, LILACS, Web of Science Core Collection, ClinicalTrials.gov and the World Health Organization Portal/ICTRP to 16 September 2020. There were no language or date restrictions applied to the electronic searches, and no methodological filters were used to restrict the search.
Selection criteria: We included randomised controlled trials (RCTs) of single and multicomponent non-pharmacological interventions for preventing delirium in hospitalised adults cared for outside intensive care or high dependency settings. We only included non-pharmacological interventions which were designed and implemented to prevent delirium. DATA COLLECTION AND ANALYSIS: Two review authors independently examined titles and abstracts identified by the search for eligibility and extracted data from full-text articles. Any disagreements on eligibility and inclusion were resolved by consensus. We used standard Cochrane methodological procedures. The primary outcomes were: incidence of delirium; inpatient and later mortality; and new diagnosis of dementia. We included secondary and adverse outcomes as pre-specified in the review protocol. We used risk ratios (RRs) as measures of treatment effect for dichotomous outcomes and between-group mean differences for continuous outcomes. The certainty of the evidence was assessed using GRADE. A complementary exploratory analysis was undertaker using a Bayesian component network meta-analysis fixed-effect model to evaluate the comparative effectiveness of the individual components of multicomponent interventions and describe which components were most strongly associated with reducing the incidence of delirium.
Main results: We included 22 RCTs that recruited a total of 5718 adult participants. Fourteen trials compared a multicomponent delirium prevention intervention with usual care. Two trials compared liberal and restrictive blood transfusion thresholds. The remaining six trials each investigated a different non-pharmacological intervention. Incidence of delirium was reported in all studies. Using the Cochrane risk of bias tool, we identified risks of bias in all included trials. All were at high risk of performance bias as participants and personnel were not blinded to the interventions. Nine trials were at high risk of detection bias due to lack of blinding of outcome assessors and three more were at unclear risk in this domain. Pooled data showed that multi-component non-pharmacological interventions probably reduce the incidence of delirium compared to usual care (10.5% incidence in the intervention group, compared to 18.4% in the control group, risk ratio (RR) 0.57, 95% confidence interval (CI) 0.46 to 0.71, I2 = 39%; 14 studies; 3693 participants; moderate-certainty evidence, downgraded due to risk of bias). There may be little or no effect of multicomponent interventions on inpatient mortality compared to usual care (5.2% in the intervention group, compared to 4.5% in the control group, RR 1.17, 95% CI 0.79 to 1.74, I2 = 15%; 10 studies; 2640 participants; low-certainty evidence downgraded due to inconsistency and imprecision). No studies of multicomponent interventions reported data on new diagnoses of dementia. Multicomponent interventions may result in a small reduction of around a day in the duration of a delirium episode (mean difference (MD) -0.93, 95% CI -2.01 to 0.14 days, I2 = 65%; 351 participants; low-certainty evidence downgraded due to risk of bias and imprecision). The evidence is very uncertain about the effect of multicomponent interventions on delirium severity (standardised mean difference (SMD) -0.49, 95% CI -1.13 to 0.14, I2=64%; 147 participants; very low-certainty evidence downgraded due to risk of bias and serious imprecision). Multicomponent interventions may result in a reduction in hospital length of stay compared to usual care (MD -1.30 days, 95% CI -2.56 to -0.04 days, I2=91%; 3351 participants; low-certainty evidence downgraded due to risk of bias and inconsistency), but little to no difference in new care home admission at the time of hospital discharge (RR 0.77, 95% CI 0.55 to 1.07; 536 participants; low-certainty evidence downgraded due to risk of bias and imprecision). Reporting of other adverse outcomes was limited. Our exploratory component network meta-analysis found that re-orientation (including use of familiar objects), cognitive stimulation and sleep hygiene were associated with reduced risk of incident delirium. Attention to nutrition and hydration, oxygenation, medication review, assessment of mood and bowel and bladder care were probably associated with a reduction in incident delirium but estimates included the possibility of no benefit or harm. Reducing sensory deprivation, identification of infection, mobilisation and pain control all had summary estimates that suggested potential increases in delirium incidence, but the uncertainty in the estimates was substantial. Evidence from two trials suggests that use of a liberal transfusion threshold over a restrictive transfusion threshold probably results in little to no difference in incident delirium (RR 0.92, 95% CI 0.62 to 1.36; I2 = 9%; 294 participants; moderate-certainty evidence downgraded due to risk of bias). Six other interventions were examined, but evidence for each was limited to single studies and we identified no evidence of delirium prevention. AUTHORS’ CONCLUSIONS: There is moderate-certainty evidence regarding the benefit of multicomponent non-pharmacological interventions for the prevention of delirium in hospitalised adults, estimated to reduce incidence by 43% compared to usual care. We found no evidence of an effect on mortality. There is emerging evidence that these interventions may reduce hospital length of stay, with a trend towards reduced delirium duration, although the effect on delirium severity remains uncertain. Further research should focus on implementation and detailed analysis of the components of the interventions to support more effective, tailored practice recommendations.
- PMID
- Keywords
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Bispectral Index Monitoring With Density Spectral Array for Delirium Detection | Luo, A. Muraida, S. Pinchotti, D. Richardson, E. Ye, E. Hollingsworth, B. Win, A. Myers, O. Langsjoen, J. Valles, E. Zolyomi, A. Quinn, D. K. | Psychosomatics | 2020 |
bispectral index monitoring |
| Delirium prediction in the intensive care unit: a temporal approach | Lucini, F. R. Fiest, K. M. Stelfox, H. T. Lee, J. | Annu Int Conf IEEE Eng Med Biol Soc | 2020 |
Alberta |
| Impact of place of residence, frailty and other factors on rehabilitation outcomes post hip fracture | Low, S. Wee, E. Dorevitch, M. | Age Ageing | 2020 |
clinical frailty scale |
| Ramelteon for Decreasing Delirium in Surgical Intensive Care Unit Patients | Lopez, C. N. Fuentes, A. Dhala, A. Balk, J. | Clinical Medicine Insights: Psychiatry | 2020 |
haloperidol |
| Different depths of sedation versus risk of delirium in adult mechanically ventilated patients: A systematic review and meta-analysis | Long, L. Ren, S. Gong, Y. Zhao, H. He, C. Shen, L. Zhao, H. Ma, P. | PLoS One | 2020 |
Adult |
| Association of Troponin Levels With Mortality in Italian Patients Hospitalized With Coronavirus Disease 2019: Results of a Multicenter Study | Lombardi, C. M. Carubelli, V. Iorio, A. Inciardi, R. M. Bellasi, A. Canale, C. Camporotondo, R. Catagnano, F. Dalla Vecchia, L. A. Giovinazzo, S. Maccagni, G. Mapelli, M. Margonato, D. Monzo, L. Nuzzi, V. Oriecuia, C. Peveri, G. Pozzi, A. Provenzale, G. S | JAMA Cardiol | 2020 |
Aged |
| Role of dexmedetomidine in the treatment of delirium in critically ill patients: a systematic review and meta-analysis | Liu, X. Xiong, J. Tang, Y. Gong, C. C. Wang, D. F. | Minerva anestesiologica | 2020 |
adult |
| Delirium Severity Trajectories and Outcomes in ICU Patients. Defining a Dynamic Symptom Phenotype | Lindroth, H. Khan, B. A. Carpenter, J. S. Gao, S. Perkins, A. J. Khan, S. H. Wang, S. Jones, R. N. Boustani, M. A. | Ann Am Thorac Soc | 2020 |
critical care |
| Risk factors for postoperative delirium in patients with triple-branched stent graft implantation | Lin, Y. Chen, Q. Zhang, H. Chen, L. W. Peng, Y. Huang, X. Chen, Y. Li, S. Lin, L. | J Cardiothorac Surg | 2020 |
Apache |
| Cerebrospinal fluid cholinergic biomarkers are associated with postoperative delirium in elderly patients undergoing Total hip/knee replacement: a prospective cohort study | Lin, X. Tang, J. Liu, C. Li, X. Cao, X. Wang, B. Dong, R. Xu, W. Yu, X. Wang, M. Bi, Y. | BMC Anesthesiol | 2020 |
Cerebrospinal fluid |
| Effect of Dexmedetomidine on Delirium in Elderly Surgical Patients: A Meta-analysis of Randomized Controlled Trials | Lin, C. Tu, H. Jie, Z. Zhou, X. Li, C. | Ann Pharmacother | 2020 |
delirium |
| The relationship between intraoperative cerebral oximetry and postoperative delirium in patients undergoing off-pump coronary artery bypass graft surgery: a retrospective study | Lim, L. Nam, K. Lee, S. Cho, Y. J. Yeom, C. W. Jung, S. Moon, J. Y. Jeon, Y. | BMC Anesthesiol | 2020 |
Cerebral oximetry |
| Effects of nonpharmacological delirium-prevention interventions on critically ill patients' clinical, psychological, and family outcomes: A systematic review and meta-analysis | Liang, S. Chau, J. P. C. Lo, S. H. S. Zhao, J. Choi, K. C. | Aust Crit Care | 2020 |
Delirium |
| Validation of PREdiction of DELIRium in ICu patients (PRE-DELIRIC) among patients in intensive care units: A retrospective cohort study | Liang, S. Chau, J. P. C. Lo, S. H. S. Bai, L. Yao, L. Choi, K. C. | Nurs Crit Care | 2020 |
Icu |
| Prognostic Impact of Delirium in Older People With/Without Dementia: A Retrospective Cohort Study in Taiwan | Liang, C. K. Chuang, H. Y. Hsiao, F. Y. Chou, M. Y. Liu, T. Y. Yang, C. C. Chen, L. K. | Journal of Nutrition, Health and Aging | 2020 |
aged |
| Effects of modified version of the Hospital Elder Life Program on post-discharge cognitive function and activities of daily living among older adults undergoing total knee arthroplasty | Liang, C. K. Chu, C. S. Hsu, Y. H. Chou, M. Y. Wang, Y. C. Lin, Y. T. Renn, J. H. Liu, T. Y. Yang, C. C. | Arch Gerontol Geriatr | 2020 |
Cognitive decline |
| Incidence and Risk Factors for Delirium in Older Patients Following Intensive Care Unit Admission: A Prospective Observational Study | Li, X. Zhang, L. Gong, F. Ai, Y. | The journal of nursing research : JNR | 2020 |
aged |
| Surviving and Thriving 1 Year After Cardiac Surgery: Frailty and Delirium Matter | Li, H. C. Wei, Y. C. Hsu, R. B. Chi, N. H. Wang, S. S. Chen, Y. S. Chen, S. Y. Chen, C. C. H. Inouye, S. K. | Annals of Thoracic Surgery | 2020 |
ADL disability |
| Pharmacist Identification of Medication Therapy Problems Involving Cognition Among Older Adults Followed by a Home-Based Care Team | Levine, A. M. P. Emonds, E. E. Smith, M. A. Rickles, N. M. Kuchel, G. A. Steffens, D. C. Ohlheiser, A. Fortinsky, R. H. | Drugs and Aging | 2020 |
aged |
| Multicomponent Interventions for the Prevention of Delirium in Hospitalized Older People: A Meta-Analysis | León-Salas, B. Trujillo-Martín, M. M. Martínez Del Castillo, L. P. García-García, J. Pérez-Ros, P. Rivas-Ruiz, F. Serrano-Aguilar, P. | J Am Geriatr Soc | 2020 |
delirium |
| Pharmacologic interventions for prevention of delirium in hospitalized older people: A meta-analysis | León-Salas, B. Trujillo-Martín, M. M. Del Castillo, L. P. M. García, J. G. Pérez-Ros, P. Ruiz, F. R. Serrano-Aguilar, P. | Arch Gerontol Geriatr | 2020 |
Aged |
| "You've got to keep moving, keep going": Understanding older patients' experiences and perceptions of delirium and nonpharmacological delirium prevention strategies in the acute hospital setting | Lee-Steere, K. Liddle, J. Mudge, A. Bennett, S. McRae, P. Barrimore, S. E. | J Clin Nurs | 2020 |
Aged |
| The Effect of Intraoperative Magnesium Sulphate Infusion on Emergence Agitation after Ambulatory Ophthalmic Surgery in Children | Lee, Y. J. Kim, B. Y. Park, J. H. Kim, S. Y. Park, H. Y. Do, S. H. | J Clin Med | 2020 |
ambulatory surgery |
| Effects of the ABCDE bundle on the prevention of post-intensive care syndrome: A retrospective study | Lee, Y. Kim, K. Lim, C. Kim, J. S. | Journal of advanced nursing | 2020 |
adult |
| Effect of Antipsychotics and Non-Pharmacotherapy for the Management of Delirium in People Receiving Palliative Care | Lee, K. Y. Tan, E. C. K. Hanrahan, J. R. Chircop, C. Michael, F. Ong, J. A. | J Pain Palliat Care Pharmacother | 2020 |
Delirium |
| Effect of magnesium supplementation on emergence delirium and postoperative pain in children undergoing strabismus surgery: a prospective randomised controlled study | Lee, J. H. Choi, S. Lee, M. Jang, Y. E. Kim, E. H. Kim, J. T. Kim, H. S. | BMC Anesthesiol | 2020 |
Emergence delirium |
| Neurologic Complications in Patients With Cancer | Lee, E. Q. | Continuum (Minneapolis, Minn.) | 2020 |
adult |
| Melatonin to prevent delirium in patients with advanced cancer: a double blind, parallel, randomized, controlled, feasibility trial | Lawlor, P. G. McNamara-Kilian, M. T. MacDonald, A. R. Momoli, F. Tierney, S. Lacaze-Masmonteil, N. Dasgupta, M. Agar, M. Pereira, J. L. Currow, D. C. Bush, S. H. | BMC Palliat Care | 2020 |
Advanced cancer |
| Cognitive function and health-related quality of life 1 year after acute brain injury: An observational study | Larsen, L. K. Møller, K. Petersen, M. Egerod, I. | Acta Anaesthesiol Scand | 2020 |
Acute brain injury |
| The One-Two Punch of Delirium and Dementia During the COVID-19 Pandemic and Beyond | LaHue, S. C. Douglas, V. C. Miller, B. L. | Front Neurol | 2020 |
Alzheimer’s disease and related dementias (ADRD) |
| Postoperative Delirium is a Risk Factor of Poor Evolution Three Years After Cardiac Surgery: An Observational Cohort Study | Labaste, F. Porterie, J. Bousquet, P. Marcheix, B. Sanchez-Verlaan, P. Frances, B. Valet, P. Dray, C. Minville, V. | Clin Interv Aging | 2020 |
cardiac surgery |
| Delirium among Hospitalized Older Adults with Acute Heart Failure Exacerbation | Kwak, M. J. Avritscher, E. Holmes, H. M. Jantea, R. Flores, R. Rianon, N. Chung, T. H. Balan, P. Dhoble, A. | J Card Fail | 2020 |
Acute Heart Failure |
| Association between polypharmacy and the persistence of delirium: a retrospective cohort study | Kurisu, K. Miyabe, D. Furukawa, Y. Shibayama, O. Yoshiuchi, K. | Biopsychosoc Med | 2020 |
Classification and regression tree |
| Elevated Procalcitonin as a Risk Factor for Postoperative Delirium in the Elderly after Cardiac Surgery-A Prospective Observational Study | Kupiec, A. Adamik, B. Kozera, N. Gozdzik, W. | J Clin Med | 2020 |
cardiac surgery |
| The CAM-ICU-7 and ICDSC as measures of delirium severity in critically ill adult patients | Krewulak, K. D. Rosgen, B. K. Ely, E. W. Stelfox, H. T. Fiest, K. M. | PLoS One | 2020 |
Adult |
| Adaptation and Validation of a Chart-Based Delirium Detection Tool for the ICU (CHART-DEL-ICU) | Krewulak, K. D. Hiploylee, C. Ely, E. W. Stelfox, H. T. Inouye, S. K. Fiest, K. M. | J Am Geriatr Soc | 2020 |
Confusion Assessment Method for Intensive Care Unit (CAM-ICU) |
| Effectiveness of an intensive care unit family education intervention on delirium knowledge: a pre-test post-test quasi-experimental study | Krewulak, K. D. Bull, M. J. Wesley Ely, E. Davidson, J. E. Stelfox, H. T. Fiest, K. M. | Can J Anaesth | 2020 |
Critical care |
| Assessment and Management of Delirium in Critically Ill Veterans | Kresevic, D. M. Miller, D. Fuseck, C. W. Wade, M. Whitney, L. Conley, M. Rimac, J. Jacono, F. O'Leary-Wilson, H. L. Burant, C. J. | Critical care nurse | 2020 |
article |
| Delirium Post-Stroke: Short- and Long-Term Effect on Depression, Anxiety, Apathy and Aggression (Research Study-Part of PROPOLIS Study) | Kowalska, K. Droś, J. Mazurek, M. Pasińska, P. Gorzkowska, A. Klimkowicz-Mrowiec, A. | J Clin Med | 2020 |
aggression |
| Intrathecal Morphine Is Associated with Less Delirium Following Hip Fracture Surgery: A Register Study | Koning, M. V. van der Sijp, M. Stolker, R. J. Niggebrugge, A. | Anesth Pain Med | 2020 |
Delirium |
| Evaluation of Pediatric Delirium Awareness and Management in Pediatric Intensive Care Units in Turkey | Konca, C. Anil, A. B. Küllüoglu, E. P. Luleyap, D. Anil, M. Tekin, M. | Journal of Pediatric Intensive Care | 2020 |
Awareness Delirium Management Pediatric Turkey |
| Preventive effect of ramelteon on emergence agitation after general anaesthesia in paediatric patients undergoing tonsillectomy: a randomised, placebo-controlled clinical trial | Komazaki, M. Mihara, T. Nakamura, N. Ka, K. Goto, T. | Sci Rep | 2020 | |
| Delirium in burn patients: developing a mobile application for assessment and diagnosis | Kolaei, N. M. M. Ayatollahi, H. Elyasi, F. | J Burn Care Res | 2020 |
Burn |
| Delirium at the end of life | Knoepfel, S. Bode, L. Gehrke, S. Spiller, T. Fuchs, S. Ernst, J. von Känel, R. Boettger, S. | Palliat Support Care | 2020 |
Delirium at the end of life |
| Protocol for the effectiveness of an anesthesiology control tower system in improving perioperative quality metrics and clinical outcomes: The tectonics randomized, pragmatic trial | King, C. R. Abraham, J. Kannampallil, T. G. Fritz, B. A. Abdallah, A. B. Chen, Y. Henrichs, B. Politi, M. Torres, B. A. Mickle, A. Budelier, T. P. McKinnon, S. Gregory, S. Kheterpal, S. Wildes, T. Avidan, M. S. Tectonics Research, Group | F1000Research | 2020 |
NCT02032030 |
| Sleep disturbance and delirium in patients with acromegaly in the early postoperative period after transsphenoidal pituitary surgery | Kim, S. H. Kim, N. Min, K. T. Kim, E. H. Oh, H. Choi, S. H. | Medicine (Baltimore) | 2020 |
Acromegaly/ surgery |
| Frontal electroencephalogram activity during emergence from general anaesthesia in children with and without emergence delirium | Kim, J. Lee, H. C. Byun, S. H. Lim, H. Lee, M. Choung, Y. Kim, E. | Br J Anaesth | 2020 |
brain waves |
| Safety and efficacy of pharmacologic agents used for rapid tranquilization of emergency department patients with acute agitation or excited delirium | Kim, H. K. Leonard, J. B. Corwell, B. N. Connors, N. J. | 2020 |
acute agitation |
|
| Effect of Timing of Intravenous Fentanyl Administration on the Incidence of Posttonsillectomy Nausea and Vomiting | Kim, H. J. Kim, M. S. Kim, H. Y. Park, W. K. Kim, W. S. Kim, S. Kim, H. J. | Laryngoscope | 2020 |
Postoperative nausea and vomiting |
| Effect on Quality of Care of a Delirium Prevention Campaign for Surgical Intensive Care Nurses | Kim, H. Lee, S. M. | Publish Ahead of Print | 2020 | |
| Ultrasound-Guided Pecto-Intercostal Fascial Block for Postoperative Pain Management in Cardiac Surgery: A Prospective, Randomized, Placebo-Controlled Trial | Khera, T. Murugappan, K. R. Leibowitz, A. Bareli, N. Shankar, P. Gilleland, S. Wilson, K. Oren-Grinberg, A. Novack, V. Venkatachalam, S. Rangasamy, V. Subramaniam, B. | J Cardiothorac Vasc Anesth | 2020 |
3-minute diagnostic Confusion Assessment Method |
| Delirium Incidence, Duration, and Severity in Critically Ill Patients With Coronavirus Disease 2019 | Khan, S. H. Lindroth, H. Perkins, A. J. Jamil, Y. Wang, S. Roberts, S. Farber, M. Rahman, O. Gao, S. Marcantonio, E. R. Boustani, M. Machado, R. Khan, B. A. | Crit Care Explor | 2020 |
brain diseases |
| Delirium, Cerebral Perfusion and High Frequency Vital Sign Monitoring in the Critically Ill: The CONFOCAL-2 Feasibility Study | Khan, J. M. Wood, M. D. Lee, K. F. H. Maslove, D. Muscedere, J. English, S. W. Ball, I. Slessarev, M. Boyd, J. G. | Annals of the American Thoracic Society | 2020 |
NCT03141619 |
| Melatonin for delirium prevention in hospitalized patients: A systematic review and meta-analysis | Khaing, K. Nair, B. R. | J Psychiatr Res | 2020 |
Delirium |
| Delirium in Older Patients With COVID-19 Presenting to the Emergency Department | Kennedy, M. Helfand, B. K. I. Gou, R. Y. Gartaganis, S. L. Webb, M. Moccia, J. M. Bruursema, S. N. Dokic, B. McCulloch, B. Ring, H. Margolin, J. D. Zhang, E. Anderson, R. Babine, R. L. Hshieh, T. Wong, A. H. Taylor, R. A. Davenport, K. Teresi, B. Fong, T. | JAMA Netw Open | 2020 |
Aged |
| Protocol for the Prognosticating Delirium Recovery Outcomes Using Wakefulness and Sleep Electroencephalography (P-DROWS-E) study: A prospective observational study of delirium in elderly cardiac surgical patients | Kendall Smith, S. Nguyen, T. Labonte, A. K. Kafashan, M. Hyche, O. Guay, C. S. Wilson, E. Chan, C. W. Luong, A. Brian Hickman, L. Fritz, B. A. Emmert, D. Graetz, T. J. Melby, S. J. Lucey, B. P. Ju, Y. E. S. Wildes, T. S. Avidan, M. S. Palanca, B. J. A. | BMJ Open | 2020 |
aged |
| Prevalence of Geriatric Syndromes and the Need for Hospice Care in Older Patients of the Emergency Department: A Study in an Asian Medical Center | Ke, Y. T. Peng, A. C. Shu, Y. M. Chung, M. H. Tsai, K. T. Chen, P. J. Weng, T. C. Hsu, C. C. Lin, H. J. Huang, C. C. | Emergency Medicine International | 2020 |
advance care planning |
| The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [11C]PBR28 binding and exploration of its link to post-operative delirium | Katsumi, Y. Racine, A. M. Torrado-Carvajal, A. Loggia, M. L. Hooker, J. M. Greve, D. N. Hightower, B. G. Catana, C. Cavallari, M. Arnold, S. E. Fong, T. G. Vasunilashorn, S. M. Marcantonio, E. R. Schmitt, E. M. Xu, G. Libermann, T. A. Barrett, L. F. Inouy | NeuroImage: Clinical | 2020 |
PET-MRI scanner |
| Association between visitation restriction during the COVID-19 pandemic and delirium incidence among emergency admission patients: a single-center retrospective observational cohort study in Japan | Kandori, K. Okada, Y. Ishii, W. Narumiya, H. Maebayashi, Y. Iizuka, R. | Journal of Intensive Care | 2020 |
adult |
| Intensive Care Unit Nurses’ Beliefs About Delirium Assessment and Management | Kimberly J. Oosterhouse, RN, PhD Catherine Vincent, RN, PhD Marquis D. Foreman, RN, PhD Valerie A. Gruss, PhD, APRN Colleen Corte, RN, PhD Barbara Berger, RN, PhD | AACN Adv Crit Care | 2016 |
beliefs; critical care nurses; delirium; older adult; vignettes |
| Using Concept Unique Identifiers to Filter Electronic Health Records for Delirium Cases | Kimberly J. Oosterhouse, PhD, RN, Cynthia D. Young, MSN, RN, Manushi Desai, MBA, RN, Steven Birch, BS, Ron Price, Jr, BA, Kathleen L. Bobay, PhD, RN, FAAN | CIN: Computers, Informatics, Nursing | 2021 |
Concept unique identifiers, Delirium, |
| Delirium incidence, risk factors, and treatments in older adults receiving chemotherapy: A systematic review and meta-analysis | Jung, P. Puts, M. Frankel, N. Syed, A. T. Alam, Z. Yeung, L. Malik, U. Rosario, C. Ayala, A. P. Hudson, J. Alibhai, S. M. H. | J Geriatr Oncol | 2020 |
Aged |
| Postoperative delirium: perioperative assessment, risk reduction, and management | Jin, Z. Hu, J. Ma, D. | Br J Anaesth | 2020 |
Blood Transfusion |
| Platelet-to-lymphocyte ratio as a predictive index for delirium in critically ill patients: A retrospective observational study | Jiang, X. Shen, Y. Fang, Q. Zhang, W. Cheng, X. | Medicine (Baltimore) | 2020 |
Aged |
| Validation of the 3-minute diagnostic interview for CAM-defined Delirium in Chinese older adults | Ji, M. Wang, J. Yang, X. Huang, Y. Xiao, Y. Wu, Y. | Geriatr Nurs | 2020 |
3d-cam |
| Diagnostic Test Accuracy of the 4AT for Delirium Detection: A Systematic Review and Meta-Analysis | Jeong, E. Park, J. Lee, J. | Int J Environ Res Public Health | 2020 |
4at |
| Development and Evaluation of Clinical Practice Guideline for Delirium in Long-Term Care | Jeong, E. Park, J. Chang, S. O. | Int J Environ Res Public Health | 2020 |
aged |
| Risk prediction of delirium in hospitalized patients using machine learning: An implementation and prospective evaluation study | Jauk, S. Kramer, D. Großauer, B. Rienmüller, S. Avian, A. Berghold, A. Leodolter, W. Schulz, S. | J Am Med Inform Assoc | 2020 |
Machine learning |
| Objectively measured sleep fragmentation is associated with incident delirium in older hospitalized patients: Analysis of data collected from an randomized controlled trial | Jaiswal, S. J. Kang, D. Y. Wineinger, N. E. Owens, R. L. | J Sleep Res | 2020 |
actigraphy |
| Incidence and predictors of delirium on the intensive care unit after acute myocardial infarction, insight from a retrospective registry | Jäckel, M. Zotzmann, V. Wengenmayer, T. Duerschmied, D. Biever, P. M. Spieler, D. von Zur Mühlen, C. Stachon, P. Bode, C. Staudacher, D. L. | Catheter Cardiovasc Interv | 2020 |
NuDesc |
| Real-World Preventive Effects of Suvorexant in Intensive Care Delirium: A Retrospective Cohort Study | Izuhara, M. Izuhara, H. K. Tsuchie, K. Araki, T. Ito, T. Sato, K. Miura, S. Otsuki, K. Nagahama, M. Hayashida, M. Hashioka, S. Wake, R. Kimura, T. Tsumoto, S. Saito, Y. Inagaki, M. | J Clin Psychiatry | 2020 |
Adolescent |
| Prognostic Value of Delirium in Patients With Acute Heart Failure in the Intensive Care Unit | Iwata, E. Kondo, T. Kato, T. Okumura, T. Nishiyama, I. Kazama, S. Ishihara, T. Kondo, S. Hiraiwa, H. Tsuda, T. Ito, M. Aoyama, M. Tanimura, D. Awaji, Y. Unno, K. Murohara, T. | Canadian Journal of Cardiology | 2020 |
acute heart failure |
| Postoperative delirium after reconstructive surgery for oral tumor: a retrospective clinical study | Ishibashi-Kanno, N. Takaoka, S. Nagai, H. Okubo-Sato, M. Fukuzawa, S. Uchida, F. Yamagata, K. Yanagawa, T. Bukawa, H. | Int J Oral Maxillofac Surg | 2020 |
Delirium |
| Vitamin D status and complications, readmissions, and mortality after hip fracture | Ingstad, F. Solberg, L. B. Nordsletten, L. Thorsby, P. M. Hestnes, I. Frihagen, F. | Osteoporos Int | 2020 |
Delirium |
| Multi-disciplinary and pharmacological interventions to reduce post-operative delirium in elderly patients: A systematic review and meta-analysis | Igwe, E. O. Nealon, J. Mohammed, M. Hickey, B. Chou, K. R. Chen, J. K. Traynor, V. | Journal of Clinical Anesthesia | 2020 |
bupivacaine |
| Preoperative serum biomarkers in the prediction of postoperative delirium following abdominal surgery | Ida, M. Takeshita, Y. Kawaguchi, M. | Geriatr Gerontol Int | 2020 |
biomarker |
| Rotigotine patch prescription in inpatients with Parkinson's disease: evaluating prescription accuracy, delirium and end-of-life use | Ibrahim, H. Woodward, Z. Pooley, J. Richfield, E. W. | Age Ageing | 2020 |
Parkinson’s disease |
| Effect of Cognitive Prehabilitation on the Incidence of Postoperative Delirium among Older Adults Undergoing Major Noncardiac Surgery: The Neurobics Randomized Clinical Trial | Humeidan, M. L. Reyes, J. P. C. Mavarez-Martinez, A. Roeth, C. Nguyen, C. M. Sheridan, E. Zuleta-Alarcon, A. Otey, A. Abdel-Rasoul, M. Bergese, S. D. | JAMA Surgery | 2020 |
aged |
| Delirium in intensive care: violence, loss and humanity | Hume, V. J. | Med Humanit | 2020 |
arts in health/arts and health |
| Neuroleptic strategies for terminal agitation in patients with cancer and delirium at an acute palliative care unit: a single-centre, double-blind, parallel-group, randomised trial | Hui, D. De La Rosa, A. Wilson, A. Nguyen, T. Wu, J. Delgado-Guay, M. Azhar, A. Arthur, J. Epner, D. Haider, A. De La Cruz, M. Heung, Y. Tanco, K. Dalal, S. Reddy, A. Williams, J. Amin, S. Armstrong, T. S. Breitbart, W. Bruera, E. | Lancet Oncol | 2020 |
Aged |
| Incidence and risk factors of delirium after percutaneous coronary intervention in individuals hospitalised for acute myocardial infarction: protocol for a systematic review and meta-analysis | Huang, K. Lu, J. Zhu, Y. Cheng, T. Du, D. Qian, X. Pan, H. Wang, X. Yang, H. Lou, S. | BMJ Open | 2020 |
coronary intervention |
| Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia: A double-blind, randomised clinical trial | Hu, J. Zhu, M. Gao, Z. Zhao, S. Feng, X. Chen, J. Zhang, Y. Maze, M. | European journal of anaesthesiology | 2020 |
aged |
| Antipsychotic prescribing to people with dementia during COVID-19 | Howard, R. Burns, A. Schneider, L. | The Lancet Neurology | 2020 |
neuroleptic agent |
| A phase II study of ramelteon for the prevention of postoperative delirium in elderly patients undergoing gastrectomy | Honda, S. Furukawa, K. Makuuchi, R. Irino, T. Tokunaga, M. Tanizawa, Y. Bando, E. Kawamura, T. Shinsato, K. Matsumoto, T. Terashima, M. | Surg Today | 2020 |
Elderly patients |
| Preventative effects of ramelteon against postoperative delirium after elective liver resection | Hokuto, D. Nomi, T. Yoshikawa, T. Matsuo, Y. Kamitani, N. Sho, M. | PLoS One | 2020 |
Adult |
| Dexmedetomidine: A Novel Strategy for Patients with Intractable Pain, Opioid-Induced Hyperalgesia, or Delirium at the End of Life | Hofherr, M. L. Abrahm, J. L. Rickerson, E. | J Palliat Med | 2020 |
delirium |
| Diagnostic Performance of Delirium Assessment Tools in Critically Ill Patients: A Systematic Review and Meta-Analysis | Ho, M. H. Montgomery, A. Traynor, V. Chang, C. C. Kuo, K. N. Chang, H. C. R. Chen, K. H. | Worldviews on evidence-based nursing | 2020 |
adult |
| Alpha2 agonist dexmedetomidine may reduce duration of delirium in critically ill adults | Hill, J. Sange, C. Clegg, A. | Evidence-based nursing | 2020 |
adult |
| Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients | Helms, J. Kremer, S. Merdji, H. Schenck, M. Severac, F. Clere-Jehl, R. Studer, A. Radosavljevic, M. Kummerlen, C. Monnier, A. Boulay, C. Fafi-Kremer, S. Castelain, V. Ohana, M. Anheim, M. Schneider, F. Meziani, F. | Crit Care | 2020 |
Aged |
| Detecting Delirium: A Systematic Review of Identification Instruments for Non-ICU Settings | Helfand, B. K. I. D'Aquila, M. L. Tabloski, P. Erickson, K. Yue, J. Fong, T. G. Hshieh, T. T. Metzger, E. D. Schmitt, E. M. Boudreaux, E. D. Inouye, S. K. Jones, R. N. | J Am Geriatr Soc | 2020 |
delirium |
| Radiological, Chemical and Pharmacological Cholinergic System Parameters and Neurocognitive Disorders in Older Pre-Surgical Adults | Heinrich, M. Müller, A. Lammers-Lietz, F. Borchers, F. Mörgeli, R. Kruppa, J. Zacharias, N. Winterer, G. Slooter, A. J. C. Spies, C. D. | J Gerontol A Biol Sci Med Sci | 2020 |
Anticholinergic Medication |
| Dexmedetomidine for the prevention of postoperative delirium in patients after intracranial operation for brain tumours (DEPOD study): a study protocol and statistical plan for a multicentre randomised controlled trial | He, X. Cheng, K. M. Zhang, L. Gu, H. Qu, X. Xu, Y. Ma, P. Zhou, J. X. | BMJ Open | 2020 |
adult intensive & critical care |
| Association between increased neutrophil-to-lymphocyte ratio and postoperative delirium in elderly patients with total hip arthroplasty for hip fracture | He, R. Wang, F. Shen, H. Zeng, Y. LijuanZhang | BMC Psychiatry | 2020 |
Elderly patients |
| The accuracy of delirium assessment by cardiologists treating heart failure inpatients: a single center retrospective survey | Hayashi, A. Kobayashi, S. Matsui, K. Akaho, R. Nishimura, K. | Biopsychosoc Med | 2020 |
Consultation-liaison psychiatry |
| Rates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents and beta-blockers: An electronic health records network study | Harrison, P. J. Luciano, S. Colbourne, L. | J Psychopharmacol | 2020 |
Delirium |
| Managing delirium in terminally ill patients: perspective of palliative care nurse specialists | Harris, C. Spiller, J. Finucane, A. | Br J Community Nurs | 2020 |
Clinical nurse specialists |
| Metabolomic and Lipidomic Profiling of Preoperative CSF in Elderly Hip Fracture Patients With Postoperative Delirium | Han, Y. Zhang, W. Liu, J. Song, Y. Liu, T. Li, Z. Wang, X. Yang, N. Li, Y. Han, D. Mi, X. Zhou, Y. Li, M. Guo, X. Zhong, L. Wang, G. Yuan, Y. | Front Aging Neurosci | 2020 |
cerebrospinal fluid |
| Increased Association With Malnutrition and Malnourishment in Older Adults Admitted With Hip Fractures Who Have Cognitive Impairment and Delirium, as Assessed by 4AT | Han, T. S. Lisk, R. Osmani, A. Sharmin, R. El Gammel, S. Yeong, K. Fluck, D. Fry, C. H. | Nutr Clin Pract | 2020 |
cognitive dysfunction |
| Delirium During Recovery in Patients With Severe COVID-19: Two Case Reports | Han, D. Wang, C. Feng, X. Wu, J. | Front Med (Lausanne) | 2020 |
Covid-19 |
| Mannitol Is Associated with Less Postoperative Delirium after Aortic Valve Surgery in Patients Treated with Bretschneider Cardioplegia | Hamiko, M. Charitos, E. I. Velten, M. Hilbert, T. Putensen, C. Treede, H. Duerr, G. D. | Thoracic and Cardiovascular Surgeon | 2020 |
adult |