What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients (Review)
- Authors
- Burton JK, Craig LE, Yong SQ, Siddiqi N, Teale EA, Woodhouse R, Barugh AJ, Shepherd AM, Brunton A, Freeman SC, Sutton AJ, Quinn TJ
- Year
- 2021
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is an acute neuropsychological disorder that is common in hospitalised patients. It can be distressing to patients and carers and it is associated with serious adverse outcomes. Treatment options for established delirium are limited and so prevention of delirium is desirable. Non-pharmacological interventions are thought to be important in delirium prevention. OBJECTIVES: To assess the effectiveness of non-pharmacological interventions designed to prevent delirium in hospitalised patients outside intensive care units (ICU).
Search methods: We searched ALOIS, the specialised register of the Cochrane Dementia and Cognitive Improvement Group, with additional searches conducted in MEDLINE, Embase, PsycINFO, CINAHL, LILACS, Web of Science Core Collection, ClinicalTrials.gov and the World Health Organization Portal/ICTRP to 16 September 2020. There were no language or date restrictions applied to the electronic searches, and no methodological filters were used to restrict the search.
Selection criteria: We included randomised controlled trials (RCTs) of single and multicomponent non-pharmacological interventions for preventing delirium in hospitalised adults cared for outside intensive care or high dependency settings. We only included non-pharmacological interventions which were designed and implemented to prevent delirium. DATA COLLECTION AND ANALYSIS: Two review authors independently examined titles and abstracts identified by the search for eligibility and extracted data from full-text articles. Any disagreements on eligibility and inclusion were resolved by consensus. We used standard Cochrane methodological procedures. The primary outcomes were: incidence of delirium; inpatient and later mortality; and new diagnosis of dementia. We included secondary and adverse outcomes as pre-specified in the review protocol. We used risk ratios (RRs) as measures of treatment effect for dichotomous outcomes and between-group mean differences for continuous outcomes. The certainty of the evidence was assessed using GRADE. A complementary exploratory analysis was undertaker using a Bayesian component network meta-analysis fixed-effect model to evaluate the comparative effectiveness of the individual components of multicomponent interventions and describe which components were most strongly associated with reducing the incidence of delirium.
Main results: We included 22 RCTs that recruited a total of 5718 adult participants. Fourteen trials compared a multicomponent delirium prevention intervention with usual care. Two trials compared liberal and restrictive blood transfusion thresholds. The remaining six trials each investigated a different non-pharmacological intervention. Incidence of delirium was reported in all studies. Using the Cochrane risk of bias tool, we identified risks of bias in all included trials. All were at high risk of performance bias as participants and personnel were not blinded to the interventions. Nine trials were at high risk of detection bias due to lack of blinding of outcome assessors and three more were at unclear risk in this domain. Pooled data showed that multi-component non-pharmacological interventions probably reduce the incidence of delirium compared to usual care (10.5% incidence in the intervention group, compared to 18.4% in the control group, risk ratio (RR) 0.57, 95% confidence interval (CI) 0.46 to 0.71, I2 = 39%; 14 studies; 3693 participants; moderate-certainty evidence, downgraded due to risk of bias). There may be little or no effect of multicomponent interventions on inpatient mortality compared to usual care (5.2% in the intervention group, compared to 4.5% in the control group, RR 1.17, 95% CI 0.79 to 1.74, I2 = 15%; 10 studies; 2640 participants; low-certainty evidence downgraded due to inconsistency and imprecision). No studies of multicomponent interventions reported data on new diagnoses of dementia. Multicomponent interventions may result in a small reduction of around a day in the duration of a delirium episode (mean difference (MD) -0.93, 95% CI -2.01 to 0.14 days, I2 = 65%; 351 participants; low-certainty evidence downgraded due to risk of bias and imprecision). The evidence is very uncertain about the effect of multicomponent interventions on delirium severity (standardised mean difference (SMD) -0.49, 95% CI -1.13 to 0.14, I2=64%; 147 participants; very low-certainty evidence downgraded due to risk of bias and serious imprecision). Multicomponent interventions may result in a reduction in hospital length of stay compared to usual care (MD -1.30 days, 95% CI -2.56 to -0.04 days, I2=91%; 3351 participants; low-certainty evidence downgraded due to risk of bias and inconsistency), but little to no difference in new care home admission at the time of hospital discharge (RR 0.77, 95% CI 0.55 to 1.07; 536 participants; low-certainty evidence downgraded due to risk of bias and imprecision). Reporting of other adverse outcomes was limited. Our exploratory component network meta-analysis found that re-orientation (including use of familiar objects), cognitive stimulation and sleep hygiene were associated with reduced risk of incident delirium. Attention to nutrition and hydration, oxygenation, medication review, assessment of mood and bowel and bladder care were probably associated with a reduction in incident delirium but estimates included the possibility of no benefit or harm. Reducing sensory deprivation, identification of infection, mobilisation and pain control all had summary estimates that suggested potential increases in delirium incidence, but the uncertainty in the estimates was substantial. Evidence from two trials suggests that use of a liberal transfusion threshold over a restrictive transfusion threshold probably results in little to no difference in incident delirium (RR 0.92, 95% CI 0.62 to 1.36; I2 = 9%; 294 participants; moderate-certainty evidence downgraded due to risk of bias). Six other interventions were examined, but evidence for each was limited to single studies and we identified no evidence of delirium prevention. AUTHORS’ CONCLUSIONS: There is moderate-certainty evidence regarding the benefit of multicomponent non-pharmacological interventions for the prevention of delirium in hospitalised adults, estimated to reduce incidence by 43% compared to usual care. We found no evidence of an effect on mortality. There is emerging evidence that these interventions may reduce hospital length of stay, with a trend towards reduced delirium duration, although the effect on delirium severity remains uncertain. Further research should focus on implementation and detailed analysis of the components of the interventions to support more effective, tailored practice recommendations.
- PMID
- Keywords
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Perioperative Dexmedetomidine Supplement Decreases Delirium Incidence After Adult Cardiac Surgery: A Randomized, Double-Blind, Controlled Study | Likhvantsev, V. V. Landoni, G. Grebenchikov, O. A. Ovezov, A. M. Skripkin, Y. V. Lembo, R. Gaevskiy, D. I. Tereshina, A. A. Yavorovskiy, A. G. | J Cardiothorac Vasc Anesth | 2021 |
Adult |
| An observational study of hypoactive delirium in the post-anesthesia recovery unit of a pediatric hospital | Lee-Archer, P. F. von Ungern-Sternberg, B. S. Reade, M. C. Law, K. C. Long, D. | Paediatr Anaesth | 2021 |
emergence delirium |
| A prospective observational cohort pilot study of the association between midazolam use and delirium in elderly endoscopy patients | Lee, D. Petersen, F. Wu, M. Chapman, G. Hayman, M. Tomkins, K. Fernando, J. | BMC Anesthesiol | 2021 |
Anaesthesia |
| Discharge from hospital with newly administered antipsychotics after intensive care unit delirium - Incidence and contributing factors | Lambert, J. Vermassen, J. Fierens, J. Peperstraete, H. Petrovic, M. Colpaert, K. | J Crit Care | 2021 |
Antipsychotics |
| Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis | Hughes, C. G. Mailloux, P. T. Devlin, J. W. Swan, J. T. Sanders, R. D. Anzueto, A. Jackson, J. C. Hoskins, A. S. Pun, B. T. Orun, O. M. Raman, R. Stollings, J. L. Kiehl, A. L. Duprey, M. S. Bui, L. N. O'Neal, H. R., Jr. Snyder, A. Gropper, M. A. Guntupall | N Engl J Med | 2021 |
Adult |
| Repeated Preoperative Intranasal Administration of Insulin Decreases the Incidence of Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Radical Gastrointestinal Surgery: A Randomized, Placebo-Controlled, Double-Blinded Clinical Study | Huang, Q. Li, Q. Qin, F. Yuan, L. Lu, Z. Nie, H. Gong, G. | Am J Geriatr Psychiatry | 2021 |
Postoperative delirium |
| The diagnostic threshold of Cornell assessment of pediatric delirium in detection of postoperative delirium in pediatric surgical patients | Hong, H. Guo, C. Liu, Z. H. Wang, B. J. Zhou, S. Z. Mu, D. L. Wang, D. X. | BMC Pediatr | 2021 |
Child |
| Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial | Hollinger, A. Rüst, C. A. Riegger, H. Gysi, B. Tran, F. Brügger, J. Huber, J. Toft, K. Surbeck, M. Schmid, H. R. Rentsch, K. Steiner, L. Siegemund, M. | J Clin Anesth | 2021 |
Adult |
| Delirium care knowledge in critical care nurses: A multiple-choice question-based quiz | Ho, M. H. Traynor, V. Chen, K. H. Montayre, J. Lin, Y. K. Chang, H. R. | Nurs Crit Care | 2021 |
critical care nursing |
| Comparison of hospital course and outcome in hospital-acquired vs pre-existing delirium | Guillory, J. Fitz-Gerald, C. Banik, A. Sterwald, C. Ashiofu, E. Knox, E. Muyco, M. A. Verlage, M. Abdali, A. O'Malley, P. W. Rezai, A. Bush, P. Brown, E. S. North, C. S. | Ann Clin Psychiatry | 2021 | |
| Dexmedetomidine reduces postoperative cognitive and behavioral dysfunction in adults submitted to general anesthesia for non-cardiac surgery: meta-analysis of randomized clinical trials | Govêia, C. S. Miranda, D. B. Oliveira, L. V. B. Praxedes, F. B. Moreira, L. G. Guimarães, G. M. N. | Braz J Anesthesiol | 2021 |
Delirium |
| An exploration of the reliability and usability of two delirium screening tools in an Australian intensive care unit: A pilot study | Ewers, R. Bloomer, M. J. Hutchinson, A. | Intensive Crit Care Nurs | 2021 |
Confusion assessment methods -ICU |
| Haloperidol and Quetiapine for the Treatment of ICU-Associated Delirium in a Tertiary Pediatric ICU: A Propensity Score-Matched Cohort Study | Cronin, M. T. Di Gennaro, J. L. Watson, R. S. Dervan, L. A. | Paediatr Drugs | 2021 |
Antipsychotic Agents/therapeutic use |
| Post-operative delirium in older hip fracture patients: a new onset or was it already there? | Costa-Martins, I. Carreteiro, J. Santos, A. Costa-Martins, M. Artilheiro, V. Duque, S. Campos, L. Chedas, M. | Eur Geriatr Med | 2021 |
Cognitive assessment |
| The Use of Tablet Computers to Reduce Preoperative Anxiety in Children Before Anesthesia: A Randomized Controlled Study | Clausen, N. G. Madsen, D. Rosenkilde, C. Hasfeldt-Hansen, D. Larsen, L. G. Hansen, T. G. | J Perianesth Nurs | 2021 |
emergence delirium |
| A gap existed between physicians' perceptions and performance of pain, agitation-sedation and delirium assessments in Chinese intensive care units | Chen, K. Yang, Y. L. Li, H. L. Xiao, D. Wang, Y. Zhang, L. Zhou, J. X. | BMC Anesthesiol | 2021 |
Analgesia |
| Association of Depressive Symptoms With Postoperative Delirium and CSF Biomarkers for Alzheimer's Disease Among Hip Fracture Patients | Chan, C. K. Sieber, F. E. Blennow, K. Inouye, S. K. Kahn, G. Leoutsakos, J. S. Marcantonio, E. R. Neufeld, K. J. Rosenberg, P. B. Wang, N. Y. Zetterberg, H. Lyketsos, C. G. Oh, E. S. | Am J Geriatr Psychiatry | 2021 |
Alzheimer’s disease |
| Delirium as a predictor of mortality and disability among hospitalized patients in Zambia | Banerdt, J. K. Mateyo, K. Wang, L. Lindsell, C. J. Riviello, E. D. Saylor, D. Heimburger, D. C. Ely, E. W. | PLoS One | 2021 | |
| Incidence and Risk Factors of Emergence Delirium after Anesthesia in Elderly Patients at a Postanesthesia Care Unit in Ethiopia: Prospective Observational Study | Assefa, M. T. Chekol, W. B. Melesse, D. Y. Nigatu, Y. A. | Patient Relat Outcome Meas | 2021 |
delirium |
| Impact of SARS-CoV-2 Infection on Cognitive Function: A Systematic Review | Alnefeesi, Y. Siegel, A. Lui, L. M. W. Teopiz, K. M. Ho, R. C. M. Lee, Y. Nasri, F. Gill, H. Lin, K. Cao, B. Rosenblat, J. D. McIntyre, R. S. | Front Psychiatry | 2021 |
Covid-19 |
| Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study | Zhou, J. Liu, C. Sun, Y. Huang, W. Ye, K. | Brain Behav Immun | 2021 |
Adult |
| Probable delirium is a presenting symptom of COVID-19 in frail, older adults: a cohort study of 322 hospitalised and 535 community-based older adults | Zazzara, M. B. Penfold, R. S. Roberts, A. L. Lee, K. A. Dooley, H. Sudre, C. H. Welch, C. Bowyer, R. C. E. Visconti, A. Mangino, M. Freidin, M. B. El-Sayed Moustafa, J. S. Small, K. S. Murray, B. Modat, M. Graham, M. S. Wolf, J. Ourselin, S. Martin, F. C. | Age Ageing | 2021 |
Aged |
| Association between intensive care unit delirium and delusional memory after critical care in mechanically ventilated patients | Yoshino, Y. Unoki, T. Sakuramoto, H. Ouchi, A. Hoshino, H. Matsuishi, Y. Mizutani, T. | Nurs Open | 2021 |
delirium |
| Delirium screening for patients in the intensive care unit: A prospective validation study of the iCAM-ICU by nurse researchers and bedside nurses in routine practice | Yang, F. Ji, M. Wu, Y. Feng, Y. Li, J. Ren, D. Ely, E. W. | Int J Nurs Stud | 2021 |
Confusion |
| Six-Minute Walk Test Predicts Postoperative Delirium After Transcatheter Aortic Valve Replacement | Yamashita, A. Suzuki, S. Otsuka, T. Matsuda, H. Ando, H. Sugimura, K. Maekawa, E. Meguro, K. Ako, J. Okamoto, H. | J Cardiothorac Vasc Anesth | 2021 |
Clinical Frailty Scale |
| Topological data analysis (TDA) enhances bispectral EEG (BSEEG) algorithm for detection of delirium | Yamanashi, T. Kajitani, M. Iwata, M. Crutchley, K. J. Marra, P. Malicoat, J. R. Williams, J. C. Leyden, L. R. Long, H. Lo, D. Schacher, C. J. Hiraoka, K. Tsunoda, T. Kobayashi, K. Ikai, Y. Kaneko, K. Umeda, Y. Kadooka, Y. Shinozaki, G. | Sci Rep | 2021 | |
| New Cutoff Scores for Delirium Screening Tools to Predict Patient Mortality | Yamanashi, T. Iwata, M. Crutchley, K. J. Sullivan, E. J. Malicoat, J. R. Anderson, Z. M. Marra, P. S. Chang, G. Kaneko, K. Shinozaki, E. Lee, S. Shinozaki, G. | J Am Geriatr Soc | 2021 |
Cam-icu |
| Intraoperative dexmedetomidine for prevention of postoperative delirium in elderly patients with mild cognitive impairment | Xin, X. Chen, J. Hua, W. Wang, H. | Int J Geriatr Psychiatry | 2021 |
Aged |
| The risk factors for postoperative delirium in adult patients after hip fracture surgery: a systematic review and meta-analysis | Wu, J. Yin, Y. Jin, M. Li, B. | Int J Geriatr Psychiatry | 2021 |
Blood Transfusion |
| Preoperative Delirium Nursing Model Initiatives to Determine the Incidence of Postoperative Delirium Among Elderly Orthopaedic Patients | Wu, H. Kapur, A. Gibson, B. Bubb, K. Alrawashdeh, M. Cipkala-Gaffin, J. | Orthop Nurs | 2021 | |
| Challenges of Delirium Management in Patients with Traumatic Brain Injury: From Pathophysiology to Clinical Practice | Williams Roberson, S. Patel, M. B. Dabrowski, W. Ely, E. W. Pakulski, C. Kotfis, K. | Curr Neuropharmacol | 2021 |
barbiturates |
| A Systematic Review of Delirium Biomarkers and Their Alignment with the NIA-AA Research Framework | Wang, S. Lindroth, H. Chan, C. Greene, R. Serrano-Andrews, P. Khan, S. Rios, G. Jabbari, S. Lim, J. Saykin, A. J. Khan, B. | J Am Geriatr Soc | 2021 |
Alzheimerʼs disease |
| Development and validation of the Terminal Delirium-Related Distress Scale to assess irreversible terminal delirium | Uchida, M. Akechi, T. Morita, T. Shima, Y. Igarashi, N. Miyashita, M. | Palliat Support Care | 2021 |
Cancer |
| Targeted metabolomics analysis of postoperative delirium | Tripp, B. A. Dillon, S. T. Yuan, M. Asara, J. M. Vasunilashorn, S. M. Fong, T. G. Metzger, E. D. Inouye, S. K. Xie, Z. Ngo, L. H. Marcantonio, E. R. Libermann, T. A. Otu, H. H. | Sci Rep | 2021 | |
| Hospitalized older adult: predictors of functional decline | Tavares, J. P. A. Nunes, Lanv Grácio, J. C. G. | Rev Lat Am Enfermagem | 2021 |
Activities of Daily Living |
| Postoperative delirium in patients undergoing tumor resection with reconstructive surgery for oral cancer | Takahashi, N. Hiraki, A. Kawahara, K. Nagata, M. Yoshida, R. Matsuoka, Y. Tanaka, T. Obayashi, Y. Sakata, J. Nakashima, H. Arita, H. Shinohara, M. Nakayama, H. | Mol Clin Oncol | 2021 |
early postoperative ambulation |
| Prevalence of ICU Delirium in Postoperative Pediatric Cardiac Surgery Patients | Staveski, S. L. Pickler, R. H. Khoury, P. R. Ollberding, N. J. Donnellan, A. L. Mauney, J. A. Lincoln, P. A. Baird, J. D. Gilliland, F. L. Merritt, A. D. Presnell, L. B. Lanese, A. R. Lisanti, A. J. Large, B. J. Fineman, L. D. Gibson, K. H. Mohler, L. A. | Pediatr Crit Care Med | 2021 |
Adolescent |
| Physostigmine for prevention of postoperative delirium and long-term cognitive dysfunction in liver surgery: A double-blinded randomised controlled trial | Spies, C. D. Knaak, C. Mertens, M. Brockhaus, W. R. Shadenok, A. Wiebach, J. Kunzmann, K. Feldheiser, A. Pratschke, J. Müller, O. Kipping, V. Fabian, M. Abels, W. Borchers, F. Akyüz, L. Ely, E. W. Wernecke, K. D. Menon, D. K. Piper, S. K. | Eur J Anaesthesiol | 2021 | |
| Intraoperative clonidine to prevent postoperative emergence delirium following sevoflurane anesthesia in pediatric patients: a randomized clinical trial | Sousa-Júnior, F. A. Souza, A. S. R. Lima, L. C. Santos Í, G. M. Menezes, L. A. P. Ratis, Papl Couceiro, T. C. M. | Braz J Anesthesiol | 2021 |
Anesthesia |
| Training hospital inpatient nursing to know (THINK) delirium: A nursing educational program | Solberg, L. M. Campbell, C. S. Jones, K. Vaughn, I. Suryadevara, U. Fernandez, C. Shorr, R. | Geriatr Nurs | 2021 |
Delirium |
| Delirium is associated with an increased morbidity and in-hospital mortality in cancer patients: Results from a prospective cohort study | Seiler, A. Blum, D. Deuel, J. W. Hertler, C. Schettle, M. Zipser, C. M. Ernst, J. Schubert, M. von Känel, R. Boettger, S. | Palliat Support Care | 2021 |
Cancer patients |
| Delirium Triage Screen/Brief Confusion Assessment Method in Adult Orthopaedic and Hematological Patients: A Validation Study | Sederstrom, J. R. Aliory, C. D. Hanneman, E. M. Buras, M. R. | Orthop Nurs | 2021 | |
| "SQiD, the Single Question in Delirium; can a single question help clinicians to detect delirium in hospitalised cancer patients?" running heading Single Question in Delirium" (Bcan-D-20-01665) | Sands, M. B. Sharma, S. Carpenter, L. Hartshorn, A. Lee, J. T. Lujic, S. Congdon, M. E. Buchanan, A. M. Agar, M. Vardy, J. L. | BMC Cancer | 2021 |
Cancer |
| Factors Impacting Early Mobilization Following Hip Fracture: An Observational Study | Said, C. M. Delahunt, M. Ciavarella, V. Al Maliki, D. Boys, A. M. Vogrin, S. Berney, S. | J Geriatr Phys Ther | 2021 | |
| Risk factors of postoperative delirium in the knee and hip replacement patients: a systematic review and meta-analysis | Rong, X. Ding, Z. C. Yu, H. D. Yao, S. Y. Zhou, Z. K. | J Orthop Surg Res | 2021 |
Hip replacement |
| Characteristics of Younger and Older Adults with Hospital-Acquired Delirium: a Claims Data Study Spanning 14 years | Rohatgi, N. Weng, Y. Ahuja, N. Lansberg, M. G. | J Gen Intern Med | 2021 |
Aged |
| Factors Associated with Hospital-Acquired Delirium in Patients 18-65 Years Old | Rohatgi, N. Weng, Y. Ahuja, N. Lansberg, M. G. | J Gen Intern Med | 2021 |
Adolescent |
| Implementation of a multicomponent intervention sign to reduce delirium in orthopaedic inpatients (MIND-ORIENT): a quality improvement project | Reppas-Rindlisbacher, C. Siddhpuria, S. Wong, E. K. Lee, J. Y. Gabor, C. Curkovic, A. Khalili, Y. Mavrak, C. De Freitas, S. Eshak, K. Patterson, C. | BMJ Open Qual | 2021 |
evidence-based practice |
| Anticholinergic Burden Does Not Influence Delirium Subtype or the Delirium-Mortality Association in Hospitalized Older Adults: Results from a Prospective Cohort Study | Rawle, M. J. McCue, L. Sampson, E. L. Davis, D. Vickerstaff, V. | Drugs Aging | 2021 | |
| Incidence and Risk Factors of Delirium in the Intensive Care Unit: A Prospective Cohort | Rahimi-Bashar, F. Abolhasani, G. Manouchehrian, N. Jiryaee, N. Vahedian-Azimi, A. Sahebkar, A. | Biomed Res Int | 2021 |
Adult |
| Implementing Delirium Prevention in the Era of COVID-19 | Radhakrishnan, N. S. Mufti, M. Ortiz, D. Maye, S. T. Melara, J. Lim, D. Rosenberg, E. I. Price, C. C. | J Alzheimers Dis | 2021 |
Aged |
| Prevalence and risk factors of delirium in psychogeriatric outpatients | Quispel-Aggenbach, D. W. P. Schep-de Ruiter, E. P. R. van Bergen, W. Bolling, J. R. Zuidema, S. U. Luijendijk, H. J. | Int J Geriatr Psychiatry | 2021 |
Aged |
| Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study | Pun, B. T. Badenes, R. Heras La Calle, G. Orun, O. M. Chen, W. Raman, R. Simpson, B. K. Wilson-Linville, S. Hinojal Olmedillo, B. Vallejo de la Cueva, A. van der Jagt, M. Navarro Casado, R. Leal Sanz, P. Orhun, G. Ferrer Gómez, C. Núñez Vázquez, K. Pi | Lancet Respir Med | 2021 |
Aged |
| Risk prediction models for emergence delirium in paediatric general anaesthesia: a systematic review | Petre, M. A. Saha, B. Kasuya, S. Englesakis, M. Gai, N. Peliowski, A. Aoyama, K. | BMJ Open | 2021 |
Anesthesia, General/ adverse effects |
| The Effects of Propofol or Dexmedetomidine Sedation on Postoperative Recovery in Elderly Patients Receiving Lower Limb Surgery under Spinal Anesthesia: A Retrospective Propensity Score-Matched Analysis | Park, J. W. Kim, E. K. Lee, H. T. Park, S. Do, S. H. | J Clin Med | 2021 |
dexmedetomidine |
| High proportion of thiamine deficiency in referred cancer patients with delirium: a retrospective descriptive study | Onishi, H. Sato, I. Uchida, N. Takahashi, T. Furuya, D. Ebihara, Y. Yoshioka, A. Ito, H. Ishida, M. | Eur J Clin Nutr | 2021 | |
| Association between discontinuation of benzodiazepine receptor agonists and post-operative delirium among inpatients with liaison intervention: A retrospective cohort study | Omichi, C. Ayani, N. Oya, N. Matsumoto, Y. Tanaka, M. Morimoto, T. Kadotani, H. Narumoto, J. | Compr Psychiatry | 2021 |
Benzodiazepines/adverse effects |
| The Independent Association of Prestroke Psychiatric Symptoms and Acute Phase Delirium with Poststroke Mortality at One Year in Nigeria | Ojagbemi, A. Bello, T. Owolabi, M. Baiyewu, O. | J Stroke Cerebrovasc Dis | 2021 |
Delirium/diagnosis/ mortality/psychology |
| Depression predicts long-term cognitive impairment in survivors of critical illness | Nordness, M. F. Bipin Patel, M. Erickson, C. R. Kiehl, A. Jackson, J. C. Raman, R. Pandharipande, P. P. Ely, E. W. Wilson, J. E. | J Trauma Acute Care Surg | 2021 |
Aged |
| Effects of uncomfortable care and histamine H2-antagonists on delirium in acute stroke: A propensity score analysis | Nakamizo, T. Kanda, T. Kudo, Y. Sugawara, E. Hashimoto, E. Okazaki, A. Usuda, M. Nagai, T. Hara, H. Johkura, K. | J Neurol Sci | 2021 |
Delirium/epidemiology/etiology |
| Family automated voice reorientation (FAVoR) intervention for mechanically ventilated patients in the intensive care unit: Study protocol for a randomized controlled trial | Munro, C. L. Liang, Z. Ji, M. Elías, M. N. Chen, X. Calero, K. Ely, E. W. | Contemp Clin Trials | 2021 |
Cognition |
| Evaluation of a delirium awareness podcast for undergraduate nursing students in Northern Ireland: a pre-/post-test study | Mitchell, G. Scott, J. Carter, G. Wilson, C. B. | BMC Nurs | 2021 |
Constructivist pedagogy |
| Impact of delirium in acute cardiac care unit after transcatheter aortic valve replacement | Luque, T. Noriega, F. J. McInerney, A. Travieso, A. Corrochano, D. Tirado-Conte, G. Ferrera, C. Fossati, S. Jimenez-Quevedo, P. Nuñez-Gil, I. Gonzalo, N. Escaned, J. Macaya, C. Fernández-Ortiz, A. Nombela-Franco, L. Viana-Tejedor, A. | Int J Cardiol | 2021 |
Aortic Valve/surgery |
| Preoperative Prognostic Nutritional Index Value is Related to Postoperative Delirium in Elderly Patients After Noncardiac Surgery: A Retrospective Cohort Study | Liu, H. Dai, M. Guan, H. Gao, X. Zhou, Y. Sun, X. Zhou, J. Hu, X. Li, X. Song, Y. Han, Y. Cao, J. | Risk Manag Healthc Policy | 2021 |
elderly patients |
| Implementation of ABCDEF care bundle in intensive care units: A cross-sectional survey | Liang, S. Chau, J. P. C. Lo, S. H. S. Li, S. Gao, M. | Nurs Crit Care | 2021 |
ABCDEF care bundle |
| Lymphocyte and NK Cell Counts Can Predict Sepsis-Associated Delirium in Elderly Patients | Li, D. Zhang, J. Bai, G. Chen, J. Cheng, W. Cui, N. | Front Aging Neurosci | 2021 |
NK cell |
| Safety and Efficacy of Dexmedetomidine in Acutely Ill Adults Requiring Noninvasive Ventilation: A Systematic Review and Meta-analysis of Randomized Trials | Lewis, K. Piticaru, J. Chaudhuri, D. Basmaji, J. Fan, E. Møller, M. H. Devlin, J. W. Alhazzani, W. | Chest | 2021 |
dexmedetomidine |
| Pharmacological strategies to prevent postoperative delirium: a systematic review and network meta-analysis | Lee, J. M. Cho, Y. J. Ahn, E. J. Choi, G. J. Kang, H. | Anesth Pain Med (Seoul) | 2021 |
Delirium |
| Evaluation of Melatonin Practices for Delirium in Pediatric Critically Ill Patients | Laudone, T. W. Beck, S. D. Lahr, H. J. | J Pediatr Pharmacol Ther | 2021 |
antipsychotic |
| Results from a double blinded, randomised, placebo-controlled, feasibility trial of melatonin for the treatment of delirium in older medical inpatients | Lange, P. W. Clayton-Chubb, D. I. Watson, R. Maier, A. B. | Intern Med J | 2021 |
Aged |
| Delirium, Cerebral Perfusion, and High-Frequency Vital-Sign Monitoring in the Critically Ill. The CONFOCAL-2 Feasibility Study | Khan, J. M. Wood, M. D. Lee, K. F. H. Maslove, D. Muscedere, J. English, S. W. Ball, I. Slessarev, M. Boyd, J. G. | Ann Am Thorac Soc | 2021 |
cerebral oxygenation |
| Preoperative brain MRI features and occurrence of postoperative delirium | Kant, I. M. J. de Bresser, J. van Montfort, S. J. T. Mutsaerts, Hjmm Witkamp, T. D. Buijsrogge, M. Spies, C. Hendrikse, J. Slooter, A. J. C. | J Psychosom Res | 2021 |
Aged |
| Intraoperative monitoring parameters and postoperative delirium: Results of a prospective cross-sectional trial | Jung, C. Hinken, L. Fischer-Kumbruch, M. Trübenbach, D. Fielbrand, R. Schenk, I. Diegmann, O. Krauß, T. Scheinichen, D. Schultz, B. | Medicine (Baltimore) | 2021 |
Adult |
| Development of the AL-O-A Score for Delirium Screening in Acute Internal Medicine: a Monocentric Prospective Study | John, G. Bovet, V. Verdon, V. Zender, H. Donzé, J. | J Gen Intern Med | 2021 |
adult |
| Intravenous Iron in a Prehabilitation Program for Older Surgical Patients: Prospective Cohort Study | Janssen, T. L. Steyerberg, E. W. van Gammeren, A. J. Ho, G. H. Gobardhan, P. D. van der Laan, L. | J Surg Res | 2021 |
Abdomen/surgery |
| Comparative associations between anticholinergic burden and emergency department visits for anticholinergic adverse events in older Korean adults: a nested case-control study using national claims data for validation of a novel country-specific scale | Hwang, S. Chung, J. E. Jun, K. Ah, Y. M. Kim, K. I. Lee, J. Y. | BMC Pharmacol Toxicol | 2021 |
Anticholinergic syndromes |
| Evaluation of QTc Interval Effects of Antipsychotic Medications for Intensive Care Unit Delirium in Pediatric Patients | Hutchins, L. M. Shipman, A. Zimmerman, K. O. Heath, T. S. | J Pediatr Pharmacol Ther | 2021 |
QTc interval prolongation |
| Implementing a Rapid, Two-Step Delirium Screening Protocol in Acute Care: Barriers and Facilitators | Husser, E. K. Fick, D. M. Boltz, M. Shrestha, P. Siuta, J. Malloy, S. Overstreet, A. Leslie, D. L. Ngo, L. Jung, Y. Inouye, S. K. Marcantonio, E. R. | J Am Geriatr Soc | 2021 |
delirium |
| Higher versus lower mean arterial pressure target management in older patients having non-cardiothoracic surgery: A prospective randomized controlled trial | Hu, A. M. Qiu, Y. Zhang, P. Zhao, R. Li, S. T. Zhang, Y. X. Zheng, Z. H. Hu, B. L. Yang, Y. L. Zhang, Z. J. | J Clin Anesth | 2021 |
Elderly patients |
| Personalized Blood Pressure Management During Cardiac Surgery With Cerebral Autoregulation Monitoring: A Randomized Trial | Hogue, C. W. Brown, C. H. th Hori, D. Ono, M. Nomura, Y. Balmert, L. C. Srdanovic, N. Grafman, J. Brady, K. | Semin Thorac Cardiovasc Surg | 2021 |
Blood pressure |
| Clinical Features and Outcomes of Patients with Dementia Compared to an Aging Cohort Hospitalized During the Initial New York City COVID-19 Wave | Harb, A. A. Chen, R. Chase, H. S. Natarajan, K. Noble, J. M. | J Alzheimers Dis | 2021 |
Aged |
| Perioperative Multidisciplinary Delirium Prevention: A Longitudinal Case Report | Hamlet, K. M. Pasternak, E. Rabai, F. Mufti, M. Hernaiz Alonso, C. Price, C. C. | A A Pract | 2021 | |
| Cerebrospinal Fluid Concentration of Neurogranin in Hip Fracture Patients with Delirium | Halaas, N. B. Zetterberg, H. Idland, A. V. Knapskog, A. B. Watne, L. O. Blennow, K. | J Alzheimers Dis | 2021 |
Alzheimer’s disease |
| A retrospective study of factors associated with persistent delirium | Goto, H. Yamauchi, T. Okumura, K. Matsuoka, K. Toritsuka, M. Yasuno, F. Uemura, H. Kuki, K. Makinodan, M. Kishimoto, T. | Psychogeriatrics | 2021 |
Case-Control Studies |
| Association Between Early Tracheostomy and Delirium in Older Adults in the United States | Gazda, A. J. Kwak, M. J. Jani, P. Dinh, K. Hussain, R. Dronavalli, G. Warner, M. Salas De Armas, I. Kumar, S. Nathan, S. Kar, B. Gregoric, I. D. Patel, B. Akkanti, B. | J Cardiothorac Vasc Anesth | 2021 |
delirium |
| Poor outcomes of delirium in the intensive care units are amplified by increasing age: A retrospective cohort study | Gao, W. Zhang, Y. P. Jin, J. F. | World J Emerg Med | 2021 |
Aging |
| Postoperative Delirium is Associated With Prolonged Head and Neck Resection and Reconstruction Surgery: An Institutional Study | Edwards, D. A. Medhavy, A. Hoffman, O. G. Hoffman, G. R. | J Oral Maxillofac Surg | 2021 |
Aged |
| Delirium Assessment in Critically Ill Older Adults: Considerations During the COVID-19 Pandemic | Duggan, M. C. Van, J. Ely, E. W. | Crit Care Clin | 2021 |
Aged |
| Delirium occurrence in older Irish adults admitted to an acute medical hospital: a prospective cohort study | Dolan, C. Mohd Zubir, M. Melvin, V. McCarthy, G. Meagher, D. Adamis, D. | Ir J Psychol Med | 2021 |
Delirium |
| Clinical utility of brain computed tomography in prediction of post-stroke delirium | Czyzycki, M. Glen, A. Slowik, A. Chrzan, R. Dziedzic, T. | J Neural Transm (Vienna) | 2021 |
Brain atrophy |
| Risk factors for long-term cognitive impairment in ICU survivors: A multicenter, prospective cohort study | Collet, M. O. Egerod, I. Thomsen, T. Wetterslev, J. Lange, T. Ebdrup, B. H. Perner, A. | Acta Anaesthesiol Scand | 2021 | |
| Integration of family caregivers in delirium prevention care for hospitalized older adults: A case study analysis | Cohen, C. Pereira, F. Kampel, T. Bélanger, L. | J Adv Nurs | 2021 |
Aged |
| Investigating how electroencephalogram measures associate with delirium: A systematic review | Boord, M. S. Moezzi, B. Davis, D. Ross, T. J. Coussens, S. Psaltis, P. J. Bourke, A. Keage, H. A. D. | Clin Neurophysiol | 2021 |
Delirium |
| Pharmacologic Management of Intensive Care Unit Delirium: Clinical Prescribing Practices and Outcomes in More Than 8500 Patient Encounters | Boncyk, C. S. Farrin, E. Stollings, J. L. Rumbaugh, K. Wilson, J. E. Marshall, M. Feng, X. Shotwell, M. S. Pandharipande, P. P. Hughes, C. G. | Anesth Analg | 2021 | |
| Predictors of delirium in older patients at the emergency department: a prospective multicentre derivation study | Béland, E. Nadeau, A. Carmichael, P. H. Boucher, V. Voyer, P. Pelletier, M. Gouin, É Daoust, R. Berthelot, S. Lamontagne, M. E. Morin, M. Lemire, S. Vu, T. T. M. Émond, M. | CJEM | 2021 |
Delirium |
| Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort | Atkins, J. L. Pilling, L. C. Heales, C. J. Savage, S. Kuo, C. L. Kuchel, G. A. Steffens, D. C. Melzer, D. | J Alzheimers Dis | 2021 |
Cohort |
| Awareness of Delirium by ICU Nurses | Asmar, I. T. Yaseen, K. S. Jaghama, M. K. Khawaja, Y. F. Alwredat, A. A. Sadaqa, M. H. | Crit Care Nurs Q | 2021 | |
| Psychiatric Clinical Profiles and Pharmacological Interactions in COVID-19 Inpatients Referred to a Consultation Liaison Psychiatry Unit: a Cross-Sectional Study | Arbelo, N. López-Pelayo, H. Sagué, M. Madero, S. Pinzón-Espinosa, J. Gomes-da-Costa, S. Ilzarbe, L. Anmella, G. Llach, C. D. Imaz, M. L. Cámara, M. M. Pintor, L. | Psychiatr Q | 2021 |
Covid-19 |
| Octogenarian patients' sleep and delirium experiences in hospital and four years after aortic valve replacement: a qualitative interview study | Amofah, H. A. Broström, A. Instenes, I. Fridlund, B. Haaverstad, R. Kuiper, K. Ranhoff, A. H. Norekvål, T. M. | BMJ Open | 2021 |
Aged, 80 and over |
| Delirium and quality of life in critically ill patients: a prospective cohort study | Luz, L. F. D. S. Santos, M. C. D. Ramos, T. A. Almeida, C. B. Rover, M. C. Dal'Pizzol, C. P. Pohren, C. L. D. S. Martins, A. V. D. S. Boniatti, M. M. | Rev Bras Ter Intensiva | 2020 |
adult |