What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Validation of the 3-minute diagnostic interview for CAM-defined Delirium in Chinese older adults | Ji, M. Wang, J. Yang, X. Huang, Y. Xiao, Y. Wu, Y. | Geriatr Nurs | 2020 |
3d-cam |
| Diagnostic Test Accuracy of the 4AT for Delirium Detection: A Systematic Review and Meta-Analysis | Jeong, E. Park, J. Lee, J. | Int J Environ Res Public Health | 2020 |
4at |
| Development and Evaluation of Clinical Practice Guideline for Delirium in Long-Term Care | Jeong, E. Park, J. Chang, S. O. | Int J Environ Res Public Health | 2020 |
aged |
| Risk prediction of delirium in hospitalized patients using machine learning: An implementation and prospective evaluation study | Jauk, S. Kramer, D. Großauer, B. Rienmüller, S. Avian, A. Berghold, A. Leodolter, W. Schulz, S. | J Am Med Inform Assoc | 2020 |
Machine learning |
| Objectively measured sleep fragmentation is associated with incident delirium in older hospitalized patients: Analysis of data collected from an randomized controlled trial | Jaiswal, S. J. Kang, D. Y. Wineinger, N. E. Owens, R. L. | J Sleep Res | 2020 |
actigraphy |
| Incidence and predictors of delirium on the intensive care unit after acute myocardial infarction, insight from a retrospective registry | Jäckel, M. Zotzmann, V. Wengenmayer, T. Duerschmied, D. Biever, P. M. Spieler, D. von Zur Mühlen, C. Stachon, P. Bode, C. Staudacher, D. L. | Catheter Cardiovasc Interv | 2020 |
NuDesc |
| Real-World Preventive Effects of Suvorexant in Intensive Care Delirium: A Retrospective Cohort Study | Izuhara, M. Izuhara, H. K. Tsuchie, K. Araki, T. Ito, T. Sato, K. Miura, S. Otsuki, K. Nagahama, M. Hayashida, M. Hashioka, S. Wake, R. Kimura, T. Tsumoto, S. Saito, Y. Inagaki, M. | J Clin Psychiatry | 2020 |
Adolescent |
| Prognostic Value of Delirium in Patients With Acute Heart Failure in the Intensive Care Unit | Iwata, E. Kondo, T. Kato, T. Okumura, T. Nishiyama, I. Kazama, S. Ishihara, T. Kondo, S. Hiraiwa, H. Tsuda, T. Ito, M. Aoyama, M. Tanimura, D. Awaji, Y. Unno, K. Murohara, T. | Canadian Journal of Cardiology | 2020 |
acute heart failure |
| Postoperative delirium after reconstructive surgery for oral tumor: a retrospective clinical study | Ishibashi-Kanno, N. Takaoka, S. Nagai, H. Okubo-Sato, M. Fukuzawa, S. Uchida, F. Yamagata, K. Yanagawa, T. Bukawa, H. | Int J Oral Maxillofac Surg | 2020 |
Delirium |
| Vitamin D status and complications, readmissions, and mortality after hip fracture | Ingstad, F. Solberg, L. B. Nordsletten, L. Thorsby, P. M. Hestnes, I. Frihagen, F. | Osteoporos Int | 2020 |
Delirium |
| Multi-disciplinary and pharmacological interventions to reduce post-operative delirium in elderly patients: A systematic review and meta-analysis | Igwe, E. O. Nealon, J. Mohammed, M. Hickey, B. Chou, K. R. Chen, J. K. Traynor, V. | Journal of Clinical Anesthesia | 2020 |
bupivacaine |
| Preoperative serum biomarkers in the prediction of postoperative delirium following abdominal surgery | Ida, M. Takeshita, Y. Kawaguchi, M. | Geriatr Gerontol Int | 2020 |
biomarker |
| Rotigotine patch prescription in inpatients with Parkinson's disease: evaluating prescription accuracy, delirium and end-of-life use | Ibrahim, H. Woodward, Z. Pooley, J. Richfield, E. W. | Age Ageing | 2020 |
Parkinson’s disease |
| Effect of Cognitive Prehabilitation on the Incidence of Postoperative Delirium among Older Adults Undergoing Major Noncardiac Surgery: The Neurobics Randomized Clinical Trial | Humeidan, M. L. Reyes, J. P. C. Mavarez-Martinez, A. Roeth, C. Nguyen, C. M. Sheridan, E. Zuleta-Alarcon, A. Otey, A. Abdel-Rasoul, M. Bergese, S. D. | JAMA Surgery | 2020 |
aged |
| Delirium in intensive care: violence, loss and humanity | Hume, V. J. | Med Humanit | 2020 |
arts in health/arts and health |
| Neuroleptic strategies for terminal agitation in patients with cancer and delirium at an acute palliative care unit: a single-centre, double-blind, parallel-group, randomised trial | Hui, D. De La Rosa, A. Wilson, A. Nguyen, T. Wu, J. Delgado-Guay, M. Azhar, A. Arthur, J. Epner, D. Haider, A. De La Cruz, M. Heung, Y. Tanco, K. Dalal, S. Reddy, A. Williams, J. Amin, S. Armstrong, T. S. Breitbart, W. Bruera, E. | Lancet Oncol | 2020 |
Aged |
| Incidence and risk factors of delirium after percutaneous coronary intervention in individuals hospitalised for acute myocardial infarction: protocol for a systematic review and meta-analysis | Huang, K. Lu, J. Zhu, Y. Cheng, T. Du, D. Qian, X. Pan, H. Wang, X. Yang, H. Lou, S. | BMJ Open | 2020 |
coronary intervention |
| Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia: A double-blind, randomised clinical trial | Hu, J. Zhu, M. Gao, Z. Zhao, S. Feng, X. Chen, J. Zhang, Y. Maze, M. | European journal of anaesthesiology | 2020 |
aged |
| Antipsychotic prescribing to people with dementia during COVID-19 | Howard, R. Burns, A. Schneider, L. | The Lancet Neurology | 2020 |
neuroleptic agent |
| A phase II study of ramelteon for the prevention of postoperative delirium in elderly patients undergoing gastrectomy | Honda, S. Furukawa, K. Makuuchi, R. Irino, T. Tokunaga, M. Tanizawa, Y. Bando, E. Kawamura, T. Shinsato, K. Matsumoto, T. Terashima, M. | Surg Today | 2020 |
Elderly patients |
| Preventative effects of ramelteon against postoperative delirium after elective liver resection | Hokuto, D. Nomi, T. Yoshikawa, T. Matsuo, Y. Kamitani, N. Sho, M. | PLoS One | 2020 |
Adult |
| Dexmedetomidine: A Novel Strategy for Patients with Intractable Pain, Opioid-Induced Hyperalgesia, or Delirium at the End of Life | Hofherr, M. L. Abrahm, J. L. Rickerson, E. | J Palliat Med | 2020 |
delirium |
| Diagnostic Performance of Delirium Assessment Tools in Critically Ill Patients: A Systematic Review and Meta-Analysis | Ho, M. H. Montgomery, A. Traynor, V. Chang, C. C. Kuo, K. N. Chang, H. C. R. Chen, K. H. | Worldviews on evidence-based nursing | 2020 |
adult |
| Alpha2 agonist dexmedetomidine may reduce duration of delirium in critically ill adults | Hill, J. Sange, C. Clegg, A. | Evidence-based nursing | 2020 |
adult |
| Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients | Helms, J. Kremer, S. Merdji, H. Schenck, M. Severac, F. Clere-Jehl, R. Studer, A. Radosavljevic, M. Kummerlen, C. Monnier, A. Boulay, C. Fafi-Kremer, S. Castelain, V. Ohana, M. Anheim, M. Schneider, F. Meziani, F. | Crit Care | 2020 |
Aged |
| Detecting Delirium: A Systematic Review of Identification Instruments for Non-ICU Settings | Helfand, B. K. I. D'Aquila, M. L. Tabloski, P. Erickson, K. Yue, J. Fong, T. G. Hshieh, T. T. Metzger, E. D. Schmitt, E. M. Boudreaux, E. D. Inouye, S. K. Jones, R. N. | J Am Geriatr Soc | 2020 |
delirium |
| Radiological, Chemical and Pharmacological Cholinergic System Parameters and Neurocognitive Disorders in Older Pre-Surgical Adults | Heinrich, M. Müller, A. Lammers-Lietz, F. Borchers, F. Mörgeli, R. Kruppa, J. Zacharias, N. Winterer, G. Slooter, A. J. C. Spies, C. D. | J Gerontol A Biol Sci Med Sci | 2020 |
Anticholinergic Medication |
| Dexmedetomidine for the prevention of postoperative delirium in patients after intracranial operation for brain tumours (DEPOD study): a study protocol and statistical plan for a multicentre randomised controlled trial | He, X. Cheng, K. M. Zhang, L. Gu, H. Qu, X. Xu, Y. Ma, P. Zhou, J. X. | BMJ Open | 2020 |
adult intensive & critical care |
| Association between increased neutrophil-to-lymphocyte ratio and postoperative delirium in elderly patients with total hip arthroplasty for hip fracture | He, R. Wang, F. Shen, H. Zeng, Y. LijuanZhang | BMC Psychiatry | 2020 |
Elderly patients |
| The accuracy of delirium assessment by cardiologists treating heart failure inpatients: a single center retrospective survey | Hayashi, A. Kobayashi, S. Matsui, K. Akaho, R. Nishimura, K. | Biopsychosoc Med | 2020 |
Consultation-liaison psychiatry |
| Rates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents and beta-blockers: An electronic health records network study | Harrison, P. J. Luciano, S. Colbourne, L. | J Psychopharmacol | 2020 |
Delirium |
| Managing delirium in terminally ill patients: perspective of palliative care nurse specialists | Harris, C. Spiller, J. Finucane, A. | Br J Community Nurs | 2020 |
Clinical nurse specialists |
| Metabolomic and Lipidomic Profiling of Preoperative CSF in Elderly Hip Fracture Patients With Postoperative Delirium | Han, Y. Zhang, W. Liu, J. Song, Y. Liu, T. Li, Z. Wang, X. Yang, N. Li, Y. Han, D. Mi, X. Zhou, Y. Li, M. Guo, X. Zhong, L. Wang, G. Yuan, Y. | Front Aging Neurosci | 2020 |
cerebrospinal fluid |
| Increased Association With Malnutrition and Malnourishment in Older Adults Admitted With Hip Fractures Who Have Cognitive Impairment and Delirium, as Assessed by 4AT | Han, T. S. Lisk, R. Osmani, A. Sharmin, R. El Gammel, S. Yeong, K. Fluck, D. Fry, C. H. | Nutr Clin Pract | 2020 |
cognitive dysfunction |
| Delirium During Recovery in Patients With Severe COVID-19: Two Case Reports | Han, D. Wang, C. Feng, X. Wu, J. | Front Med (Lausanne) | 2020 |
Covid-19 |
| Mannitol Is Associated with Less Postoperative Delirium after Aortic Valve Surgery in Patients Treated with Bretschneider Cardioplegia | Hamiko, M. Charitos, E. I. Velten, M. Hilbert, T. Putensen, C. Treede, H. Duerr, G. D. | Thoracic and Cardiovascular Surgeon | 2020 |
adult |
| Comparison of the prevalence and associated factors of hyperactive delirium in advanced cancer patients between inpatient palliative care and palliative home care | Hamano, J. Mori, M. Ozawa, T. Sasaki, J. Kawahara, M. Nakamura, A. Hashimoto, K. Hisajima, K. Koga, T. Goto, K. Fukumoto, K. Morimoto, Y. Goshima, M. Sekimoto, G. Baba, M. Oya, K. Matsunuma, R. Azuma, Y. Imai, K. Morita, T. Shinjo, T. | Cancer Med | 2020 |
advanced cancer patients |
| Treatment of delirium in palliative patients - role of neuroleptics | Hainsch-Müller, I. Aulmann, C. Djukic, I. | Internistische Praxis | 2020 |
neuroleptic agent |
| Identifying Delirium Early after Stroke: A New Prediction Tool for the Intensive Care Unit | Haight, T. N. Marsh, E. B. | J Stroke Cerebrovasc Dis | 2020 |
Adult |
| Socioeconomic Factors and Intensive Care Unit-Related Cognitive Impairment | Haddad, D. N. Mart, M. F. Wang, L. Lindsell, C. J. Raman, R. Nordness, M. F. Sharp, K. W. Pandharipande, P. P. Girard, T. D. Ely, E. W. Patel, M. B. | Ann Surg | 2020 |
Aged |
| Opioid use is Associated with ICU Delirium in Mechanically Ventilated Children | Gupta, N. Woolley, A. Talathi, S. Davlyatov, G. Colston, C. Hayes, L. | J Crit Care Med (Targu Mures) | 2020 |
intensive care unit |
| A two-year multicenter point prevalence study of older patients with hip fractures admitted to rehabilitation units in Italy | Guerzoni, V. Lanzoni, A. Pozzi, C. Paci, M. Gatti, R. Benedetti, M. G. Gentile, S. Trabucchi, M. Bellelli, G. Morandi, A. | Eur Geriatr Med | 2020 |
Delirium |
| Preoperative Cognitive Impairment and Postoperative Delirium Predict Decline in Activities of Daily Living after Cardiac Surgery-A Prospective, Observational Cohort Study | Guenther, U. Hoffmann, F. Dewald, O. Malek, R. Brimmers, K. Theuerkauf, N. Putensen, C. Popp, J. | Geriatrics (Basel) | 2020 |
activity of daily living |
| Risk Factors for Delirium and Cognitive Decline Following Coronary Artery Bypass Grafting Surgery: A Systematic Review and Meta-Analysis | Greaves, D. Psaltis, P. J. Davis, D. H. J. Ross, T. J. Ghezzi, E. S. Lampit, A. Smith, A. E. Keage, H. A. D. | J Am Heart Assoc | 2020 |
cognitive decline |
| Prevalence and risk factors of delirium in the intensive care unit: An observational study | Gravante, F. Giannarelli, D. Pucci, A. Gagliardi, A. M. Mitello, L. Montagna, A. Latina, R. | Nurs Crit Care | 2020 |
delirium |
| Health Care Professionals' Reports of Cancer Pain Cues Among Older People With Delirium: A Qualitative-Quantitative Content Analysis | Graham, C. A. Chaves, G. Harrison, R. Gauthier, L. R. Nissim, R. Zimmermann, C. Chan, V. Rodin, G. Stevens, B. Gagliese, L. | J Pain Symptom Manage | 2020 |
Cancer pain |
| Benzodiazepinics and the treatment of delirium: a literature review | Gonçalves, O. H. P. Pellissari, G. M. Paiva, H. S. | Rev Assoc Med Bras (1992) | 2020 |
Benzodiazepines/therapeutic use |
| Analysis of Delirium from the Dynamic Symptoms Model: A Literature Review | Gómez Tovar, L. O. Henao Castaño, A. M. | Critical Care Nursing Quarterly | 2020 |
conceptual framework |
| Association of delirium with long-term cognitive decline: A meta-analysis | Goldberg, T. E. Chen, C. Wang, Y. Jung, E. Swanson, A. Ing, C. Garcia, P. S. Whittington, R. A. Moitra, V. | JAMA Neurology | 2020 |
article |
| Functional and cognitive decline in older delirious adults after an emergency department visit | Giroux, M. Émond, M. Nadeau, A. Boucher, V. Carmichael, P. H. Voyer, P. Pelletier, M. Gouin, É Daoust, R. Berthelot, S. Lamontagne, M. E. Morin, M. Lemire, S. Sirois, M. J. | Age Ageing | 2020 |
cognitive decline |
| The prevalence rates and sequelae of delirium at age older than 90 years | Gehrke, S. Bode, L. Seiler, A. Ernst, J. von Känel, R. Boettger, S. | Palliat Support Care | 2020 |
Delirium |
| Complications of LVAD utilization in older adults | Gazda, A. J. Kwak, M. J. Akkanti, B. Nathan, S. Kumar, S. de Armas, I. S. Baer, P. Patel, B. Kar, B. Gregoric, I. D. | Heart and Lung | 2020 |
aged |
| Consolidated framework for advancing implementation science for the implementation process and adherence assessment of a non-pharmacological delirium prevention program | Garrido, M. A. Alvarez, E. A. Ponce, D. P. Salech, F. Tobar, D. I. Tobar, E. A. | Int J Geriatr Psychiatry | 2020 |
Cfir |
| Delirium and Adverse Outcomes in Hospitalized Patients with COVID-19 | Garcez, F. B. Aliberti, M. J. R. Poco, P. C. E. Hiratsuka, M. Takahashi, S. D. F. Coelho, V. A. Salotto, D. B. Moreira, M. L. V. Jacob-Filho, W. Avelino-Silva, T. J. | Journal of the American Geriatrics Society | 2020 |
mechanical ventilator |
| The Effects of Melatonin Supplementation on Sleep Quality and Assessment of the Serum Melatonin in ICU Patients: A Randomized Controlled Trial | Gandolfi, J. V. Di Bernardo, A. P. A. Chanes, D. A. V. Martin, D. F. Joles, V. B. Amendola, C. P. Sanches, L. C. Ciorlia, G. L. Lobo, S. M. | Critical care medicine | 2020 |
adult |
| Atypical presentation of COVID-19 in hospitalised older adults | Gan, J. M. Kho, J. Akhunbay-Fudge, M. Choo, H. M. Wright, M. Batt, F. Mandal, A. K. J. Chauhan, R. Missouris, C. G. | Ir J Med Sci | 2020 |
Atypical symptoms |
| Delirium in elderly patients: Prospective prevalence across hospital services | Fuchs, S. Bode, L. Ernst, J. Marquetand, J. von Känel, R. Böttger, S. | Gen Hosp Psychiatry | 2020 |
>65 years |
| Ascertainment of delirium status using natural language processing from electronic health records | Fu, S. Lopes, G. S. Pagali, S. R. Thorsteinsdottir, B. LeBrasseur, N. K. Wen, A. Liu, H. Rocca, W. A. Olson, J. E. St Sauver, J. Sohn, S. | J Gerontol A Biol Sci Med Sci | 2020 |
confusion assessment method |
| A Multi-Phase Quality Improvement Initiative for the Treatment of Active Delirium in Older Persons | Friedman, J. I. Li, L. Kirpalani, S. Zhong, X. Freeman, R. Cheng, Y. T. Alfonso, F. L. McAlpine, G. Vakil, A. Macon, B. Francaviglia, P. Cassara, M. LoPachin, V. Reina, K. Davis, K. Reich, D. Craven, C. K. Mazumdar, M. Siu, A. L. | J Am Geriatr Soc | 2020 |
Confusion Assessment Method |
| Delirium diagnostic tool-provisional (DDT-Pro) scores in delirium, subsyndromal delirium and no delirium | Franco, J. G. Trzepacz, P. T. Sepúlveda, E. Ocampo, M. V. Velásquez-Tirado, J. D. Zaraza, D. R. Restrepo, C. Giraldo, A. M. Serna, P. A. Zuluaga, A. López, C. | Gen Hosp Psychiatry | 2020 |
Cluster analysis |
| A multimodal sevoflurane-based sedation regimen in combination with targeted temperature management in post-cardiac arrest patients reduces the incidence of delirium: An observational propensity score-matched study | Foudraine, N. A. Algargoush, A. van Osch, F. H. Bos, A. T. | Resuscitation | 2020 |
Cardiac arrest |
| Association of Plasma Neurofilament Light with Postoperative Delirium | Fong, T. G. Vasunilashorn, S. M. Ngo, L. Libermann, T. A. Dillon, S. T. Schmitt, E. M. Pascual-Leone, A. Arnold, S. E. Jones, R. N. Marcantonio, E. R. Inouye, S. K. | Ann Neurol | 2020 |
Aged |
| Course and Recognition of Poststroke Delirium: A Prospective Noninferiority Trial of Delirium Screening Tools | Fleischmann, R. Warwas, S. Andrasch, T. Kunz, R. Witt, C. Mengel, A. von Sarnowski, B. | Stroke | 2020 |
delirium |
| The collateral history: an overlooked core clinical skill | Fitzpatrick, D. Doyle, K. Finn, G. Gallagher, P. | Eur Geriatr Med | 2020 |
Clinical training |
| Management of delirium superimposed on dementia in a dementia service | FitzGerald, J. Yan, M. Bandecar, A. Ratnasabapathy, V. Rubinsztein, J. Hatfield, C. Ruhi, S. | Progress in Neurology and Psychiatry | 2020 |
adult |
| Partnering With Family Members to Detect Delirium in Critically Ill Patients | Fiest, K. M. Krewulak, K. D. Ely, E. W. Davidson, J. E. Ismail, Z. Sept, B. G. Stelfox, H. T. | Crit Care Med | 2020 |
adult |
| The correlation of intraoperative hypotension and postoperative cognitive impairment: a meta-analysis of randomized controlled trials | Feng, X. Hu, J. Hua, F. Zhang, J. Zhang, L. Xu, G. | BMC Anesthesiol | 2020 |
Intraoperative hypotension |
| The effect of joints range of motion exercises on delirium prevention in patients admitted to intensive care units | Farzammanesh, A. Jahani, S. Rashidi, M. Maraghi, E. Ravanbakhsh, M. | International Journal of Pharmaceutical and Phytopharmacological Research | 2020 |
IRCT20180114038362N1 |
| Sleep and Delirium in Older Adults | Farasat, S. Dorsch, J. J. Pearce, A. K. Moore, A. A. Martin, J. L. Malhotra, A. Kamdar, B. B. | Curr Sleep Med Rep | 2020 |
Acetylcholine |
| Association between use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and postoperative delirium | Farag, E. Farag, E. Liang, C. Liang, C. Mascha, E. J. Mascha, E. J. Argalious, M. Y. Ezell, J. Maheshwari, K. Esa, W. A. S. Troianos, C. A. Sessler, D. I. | Anesthesiology | 2020 |
adult |
| Delirium in cardiology: An old problem, a new emergency | Falsini, G. Romanelli, S. Insana, L. Frongillo, D. Grotti, S. Angioli, P. Ducci, K. Liistro, F. Calchetti, B. Rossi, R. Bolognese, L. | Giornale Italiano di Cardiologia | 2020 |
attitude to illness |
| Surveying work-as-done in post-operative delirium risk factors collection and diagnosis monitoring | Falegnami, A. Patriarca, R. Costantino, F. Di Gravio, G. Bilotta, F. | Appl Ergon | 2020 |
RiskSOAP |
| Psychiatric disorders, delirium and mortality in patients referred for consultation in a burn center: A four-year retrospective study | Erdoğan, E. Delibaş, D. H. | Medical Journal of Bakirkoy | 2020 |
antidepressant agent |
| Delirium in Older People with COVID-19: Clinical Scenario and Literature Review | Emmerton, D. Abdelhafiz, A. | SN Compr Clin Med | 2020 |
Covid-19 |
| "It should not be that difficult to manage a condition that is so frequent": A qualitative study on hospital nurses' experience of delirium guidelines | Emme, C. | J Clin Nurs | 2020 |
Adult |
| Where should patients with or at risk of delirium be treated in an acute care system? Comparing the rates of delirium in patients receiving usual care versus alternative care: a systematic review and meta-analysis | Ekeozor, C. U. Jeyaruban, D. Lasserson, D. | Int J Clin Pract | 2020 |
Acute care |
| Effect of General Versus Spinal Anesthesia on Postoperative Delirium and Early Cognitive Dysfunction in Elderly Patients | Ehsani, R. Djalali Motlagh, S. Zaman, B. Sehat Kashani, S. Ghodraty, M. R. | Anesth Pain Med | 2020 |
Delirium |
| Anticholinergic Drug Burden and Delirium: A Systematic Review | Egberts, A. Moreno-Gonzalez, R. Alan, H. Ziere, G. Mattace-Raso, F. U. S. | Journal of the American Medical Directors Association | 2020 |
adult |
| Antipsychotics and Lorazepam During Delirium: Are We Harming Older Patients? A Real-Life Data Study | Egberts, A. Alan, H. Ziere, G. Mattace-Raso, F. U. S. | Drugs and Aging | 2020 |
acutely ill patient |
| Delirium in Internal Medicine Departments in a Tertiary Hospital in Israel: Occurrence, Detection Rates, Risk Factors, and Outcomes | Efraim, N. T. Zikrin, E. Shacham, D. Katz, D. Makulin, E. Barski, L. Zeller, L. Bartal, C. Freud, T. Lebedinski, S. Press, Y. | Front Med (Lausanne) | 2020 |
delirium |
| Development and validation of an aetiology in delirium diagnostic support tool | Eeles, E. Huang, L. Dakin, L. Ling, C. Dunn, E. Fraser, J. Dissanayaka, N. N. | Age Ageing | 2020 |
aetiology |
| Association of Geriatric Events With Perioperative Outcomes After Elective Inpatient Surgery | Dworsky, J. Q. Shellito, A. D. Childers, C. P. Copeland, T. P. Maggard-Gibbons, M. Tan, H. J. Saliba, D. Russell, M. M. | J Surg Res | 2020 |
Elderly |
| Is there an association between subjective sleep quality and daily delirium occurrence in critically ill adults? A post hoc analysis of a randomised controlled trial | Duprey, M. S. Devlin, J. W. Skrobik, Y. | BMJ Open Respir Res | 2020 |
clinical epidemiology |
| Approaches to Optimize Medication Data Analysis in Clinical Cohort Studies | Duprey, M. S. Devlin, J. W. Briesacher, B. A. Travison, T. G. Griffith, J. L. Inouye, S. K. | J Am Geriatr Soc | 2020 |
delirium |
| Delirium definition influences prediction of functional survival in patients one-year postcardiac surgery | Dubiel, C. Hiebert, B. M. Stammers, A. N. Sanjanwala, R. M. Tangri, N. Singal, R. K. Manji, R. A. Rudolph, J. L. Arora, R. C. | J Thorac Cardiovasc Surg | 2020 |
cardiac surgery |
| Prevalence and outcome of delirium among acute general medical inpatients in Cape Town, South Africa | Du Plooy, N. Day, C. Manning, K. Abdullah, F. James, K. Grace, L. Vorajee, N. April, C. Peter, J. Peter, J. Raubenheimer, P. J. | South African Medical Journal | 2020 |
indwelling urinary catheter |
| Delirium Post-Stroke-Influence on Post-Stroke Dementia (Research Study-Part of the PROPOLIS Study) | Droś, J. Kowalska, K. Pasińska, P. Szyper-Maciejowska, A. Gorzkowska, A. Klimkowicz-Mrowiec, A. | J Clin Med | 2020 |
cognitive impairment |
| Providing Evidence-Based Care, Day and Night: A Quality Improvement Initiative to Improve Intensive Care Unit Patient Sleep Quality | Douglas, S. L. Hobbs, H. A. Sibley, S. R. Digby, G. C. | J Intensive Care Med | 2020 |
critical care |
| An Implementation-Effectiveness Study of a Perioperative Delirium Prevention Initiative for Older Adults | Donovan, A. L. Braehler, M. R. Robinowitz, D. L. Lazar, A. A. Finlayson, E. Rogers, S. Douglas, V. C. Whitlock, E. L. | Anesth Analg | 2020 |
Aged |
| Effectiveness of a multidisciplinary comprehensive intervention model based on the Hospital Elderly Life Program to prevent delirium in patients with severe acute pancreatitis | Dong, Z. Song, J. Ge, M. Lin, C. Zhang, J. Chen, J. Wu, Y. | Ann Palliat Med | 2020 |
Pancreatitis |
| Does Preoperative Comprehensive Geriatric Assessment and Frailty Predict Postoperative Complications? | Dogrul, R. T. Dogrul, A. B. Konan, A. Caglar, O. Sumer, F. Caliskan, H. Kizilarslanoglu, M. C. Kilic, M. K. Balci, C. Arik, G. Aycicek, G. S. Ozsurekci, C. Halil, M. Cankurtaran, M. Yavuz, B. B. | World journal of surgery | 2020 |
aged |
| Preoperative Acute Pain Is Associated with Postoperative Delirium | Ding, X. Gao, X. Chen, Q. Jiang, X. Li, Y. Xu, J. Qin, G. Lu, S. Huang, D. | Pain Med | 2020 |
C-Reactive Protein |
| Effects of electroencephalography and regional cerebral oxygen saturation monitoring on perioperative neurocognitive disorders: a systematic review and meta-analysis | Ding, L. Chen, D. X. Li, Q. | BMC Anesthesiol | 2020 |
Electroencephalography |
| The Addition of Intravenous Propofol and Ketorolac to a Sevoflurane Anesthetic Lessens Emergence Agitation in Children Having Bilateral Myringotomy with Tympanostomy Tube Insertion: A Prospective Observational Study | d'Eon, B. Hackmann, T. Wright, A. S. | Children (Basel) | 2020 |
emergence agitation |
| Preoperative Nutritional Status and Risk for Subsyndromal Delirium in Older Adults Following Joint Replacement Surgery | Denny, D. L. Trotter, T. Lindseth, G. | Orthopedic nursing | 2020 |
aged |
| Non-pharmacological interventions to reduce the incidence and duration of delirium in critically ill patients: A systematic review and network meta-analysis | Deng, L. X. Cao, L. Zhang, L. N. Peng, X. B. Zhang, L. | J Crit Care | 2020 |
Delirium prevention |
| Multidimensional nursing interventions effect on delirium and hospital admission duration | Dehghani, S. Asadizaker, M. Adineh, M. Maraghi, E. Akbarian, S. Ramezani, B. | International Journal of Pharmaceutical and Phytopharmacological Research | 2020 |
IRCT20181005041233N1 |
| Effects of pain, sedation and delirium monitoring on clinical and economic outcome: A retrospective study | Deffland, M. Spies, C. Weiss, B. Keller, N. Jenny, M. Kruppa, J. Balzer, F. | PLoS ONE | 2020 |
NCT02265263 |
| The association of post-operative delirium with health-related quality of life and mortality after lung transplantation | DeBolt, C. Gao, Y. Sutter, N. Soong, A. Trinh, B. N. Kukreja, J. Kleinhenz, M. Venado, A. Leard, L. E. Hays, S. Greenland, J. R. Shah, R. J. Douglas, V. Kolaitis, N. A. Diamond, J. M. Smith, P. J. Singer, J. P. | American Journal of Respiratory and Critical Care Medicine | 2020 |
adult |
| Development and validation of a delirium risk prediction preoperative model for cardiac surgery patients (DELIPRECAS): An observational multicentre study | de la Varga-Martínez, O. Gómez-Pesquera, E. Muñoz-Moreno, M. F. Marcos-Vidal, J. M. López-Gómez, A. Rodenas-Gómez, F. Ramasco, F. Álvarez-Refojo, F. Tamayo, E. Gómez-Sánchez, E. | J Clin Anesth | 2020 |
Cardiac surgery |