What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients (Review)
- Authors
- Burton JK, Craig LE, Yong SQ, Siddiqi N, Teale EA, Woodhouse R, Barugh AJ, Shepherd AM, Brunton A, Freeman SC, Sutton AJ, Quinn TJ
- Year
- 2021
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is an acute neuropsychological disorder that is common in hospitalised patients. It can be distressing to patients and carers and it is associated with serious adverse outcomes. Treatment options for established delirium are limited and so prevention of delirium is desirable. Non-pharmacological interventions are thought to be important in delirium prevention. OBJECTIVES: To assess the effectiveness of non-pharmacological interventions designed to prevent delirium in hospitalised patients outside intensive care units (ICU).
Search methods: We searched ALOIS, the specialised register of the Cochrane Dementia and Cognitive Improvement Group, with additional searches conducted in MEDLINE, Embase, PsycINFO, CINAHL, LILACS, Web of Science Core Collection, ClinicalTrials.gov and the World Health Organization Portal/ICTRP to 16 September 2020. There were no language or date restrictions applied to the electronic searches, and no methodological filters were used to restrict the search.
Selection criteria: We included randomised controlled trials (RCTs) of single and multicomponent non-pharmacological interventions for preventing delirium in hospitalised adults cared for outside intensive care or high dependency settings. We only included non-pharmacological interventions which were designed and implemented to prevent delirium. DATA COLLECTION AND ANALYSIS: Two review authors independently examined titles and abstracts identified by the search for eligibility and extracted data from full-text articles. Any disagreements on eligibility and inclusion were resolved by consensus. We used standard Cochrane methodological procedures. The primary outcomes were: incidence of delirium; inpatient and later mortality; and new diagnosis of dementia. We included secondary and adverse outcomes as pre-specified in the review protocol. We used risk ratios (RRs) as measures of treatment effect for dichotomous outcomes and between-group mean differences for continuous outcomes. The certainty of the evidence was assessed using GRADE. A complementary exploratory analysis was undertaker using a Bayesian component network meta-analysis fixed-effect model to evaluate the comparative effectiveness of the individual components of multicomponent interventions and describe which components were most strongly associated with reducing the incidence of delirium.
Main results: We included 22 RCTs that recruited a total of 5718 adult participants. Fourteen trials compared a multicomponent delirium prevention intervention with usual care. Two trials compared liberal and restrictive blood transfusion thresholds. The remaining six trials each investigated a different non-pharmacological intervention. Incidence of delirium was reported in all studies. Using the Cochrane risk of bias tool, we identified risks of bias in all included trials. All were at high risk of performance bias as participants and personnel were not blinded to the interventions. Nine trials were at high risk of detection bias due to lack of blinding of outcome assessors and three more were at unclear risk in this domain. Pooled data showed that multi-component non-pharmacological interventions probably reduce the incidence of delirium compared to usual care (10.5% incidence in the intervention group, compared to 18.4% in the control group, risk ratio (RR) 0.57, 95% confidence interval (CI) 0.46 to 0.71, I2 = 39%; 14 studies; 3693 participants; moderate-certainty evidence, downgraded due to risk of bias). There may be little or no effect of multicomponent interventions on inpatient mortality compared to usual care (5.2% in the intervention group, compared to 4.5% in the control group, RR 1.17, 95% CI 0.79 to 1.74, I2 = 15%; 10 studies; 2640 participants; low-certainty evidence downgraded due to inconsistency and imprecision). No studies of multicomponent interventions reported data on new diagnoses of dementia. Multicomponent interventions may result in a small reduction of around a day in the duration of a delirium episode (mean difference (MD) -0.93, 95% CI -2.01 to 0.14 days, I2 = 65%; 351 participants; low-certainty evidence downgraded due to risk of bias and imprecision). The evidence is very uncertain about the effect of multicomponent interventions on delirium severity (standardised mean difference (SMD) -0.49, 95% CI -1.13 to 0.14, I2=64%; 147 participants; very low-certainty evidence downgraded due to risk of bias and serious imprecision). Multicomponent interventions may result in a reduction in hospital length of stay compared to usual care (MD -1.30 days, 95% CI -2.56 to -0.04 days, I2=91%; 3351 participants; low-certainty evidence downgraded due to risk of bias and inconsistency), but little to no difference in new care home admission at the time of hospital discharge (RR 0.77, 95% CI 0.55 to 1.07; 536 participants; low-certainty evidence downgraded due to risk of bias and imprecision). Reporting of other adverse outcomes was limited. Our exploratory component network meta-analysis found that re-orientation (including use of familiar objects), cognitive stimulation and sleep hygiene were associated with reduced risk of incident delirium. Attention to nutrition and hydration, oxygenation, medication review, assessment of mood and bowel and bladder care were probably associated with a reduction in incident delirium but estimates included the possibility of no benefit or harm. Reducing sensory deprivation, identification of infection, mobilisation and pain control all had summary estimates that suggested potential increases in delirium incidence, but the uncertainty in the estimates was substantial. Evidence from two trials suggests that use of a liberal transfusion threshold over a restrictive transfusion threshold probably results in little to no difference in incident delirium (RR 0.92, 95% CI 0.62 to 1.36; I2 = 9%; 294 participants; moderate-certainty evidence downgraded due to risk of bias). Six other interventions were examined, but evidence for each was limited to single studies and we identified no evidence of delirium prevention. AUTHORS’ CONCLUSIONS: There is moderate-certainty evidence regarding the benefit of multicomponent non-pharmacological interventions for the prevention of delirium in hospitalised adults, estimated to reduce incidence by 43% compared to usual care. We found no evidence of an effect on mortality. There is emerging evidence that these interventions may reduce hospital length of stay, with a trend towards reduced delirium duration, although the effect on delirium severity remains uncertain. Further research should focus on implementation and detailed analysis of the components of the interventions to support more effective, tailored practice recommendations.
- PMID
- Keywords
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Is Perioperative Dexmedetomidine Associated With a Reduced Risk of Perioperative Neurocognitive Disorders Following Cardiac Surgery? A Systematic Review and Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials | Xiong, X. Chen, D. Shi, J. | Front Med (Lausanne) | 2021 |
cardiac surgery |
| The effect of pre-operative methylprednisolone on postoperative delirium in elderly patients undergoing gastrointestinal surgery: a randomized, double-blind, placebo-controlled trial | Xiang, X. B. Chen, H. Wu, Y. L. Wang, K. Yue, X. Cheng, X. Q. | J Gerontol A Biol Sci Med Sci | 2021 |
Delirium |
| Social Determinants of Health and Delirium Occurrence and Duration in Critically Ill Adults | Wu, T. T. Zegers, M. Kooken, R. Griffith, J. L. Molnar, B. E. Devlin, J. W. van den Boogaard, M. | Crit Care Explor | 2021 |
delirium |
| Implementation of a Frailty Assessment and Targeted Care Interventions and Its Association with Reduced Postoperative Complications in Elderly Surgical Patients | Wilson, S. Sutherland, E. Razak, A. O'Brien, M. Ding, C. Nguyen, T. Rosenkranz, P. Sanchez, S. E. | J Am Coll Surg | 2021 |
Frailty, Postoperative outcomes, Geriatrics, Frailty assessment |
| Prevalence of Mimics and Severe Comorbidity in Patients with Clinically Suspected Transient Global Amnesia | Werner, R. Woehrle, J. C. | Cerebrovasc Dis | 2021 |
Adult |
| The risk of delirium and falls or fractures with the use of overactive bladder anticholinergic medications | Welk, B. Etaby, K. McArthur, E. Chou, Q. | Neurourol Urodyn | 2021 |
anticholinergics |
| Hospitalization Outcomes of Delirium in Patients Admitted to Acute Care Hospitals in Their Last Year of Life: A Population-Based Retrospective Cohort Study | Webber, C. Watt, C. L. Bush, S. H. Lawlor, P. G. Talarico, R. Tanuseputro, P. | J Pain Symptom Manage | 2021 |
Adult |
| Anticholinergics and clinical outcomes amongst people with pre-existing dementia: A systematic review | Wang, K. Alan, J. Page, A. T. Dimopoulos, E. Etherton-Beer, C. | Maturitas | 2021 |
Anticholinergic |
| Association Between Intraoperative Arterial Hypotension and Postoperative Delirium After Noncardiac Surgery: A Retrospective Multicenter Cohort Study | Wachtendorf, L. J. Azimaraghi, O. Santer, P. Linhardt, F. C. Blank, M. Suleiman, A. Ahn, C. Low, Y. H. Teja, B. Kendale, S. M. Schaefer, M. S. Houle, T. T. Pollard, R. J. Subramaniam, B. Eikermann, M. Wongtangman, K. | Anesth Analg | 2021 |
Intraoperative Arterial Hypotension, Postoperative delirium, Surgery, Anesthesia |
| Dynamic assessments of hepatic encephalopathy and ammonia levels predict mortality in acute-on-chronic liver failure | Verma, N. Dhiman, R. K. Choudhury, A. Taneja, S. Duseja, A. Singh, V. Al Mahtab, M. Devarbhavi, H. Shukla, A. Ning, Q. Hamid, S. S. Butt, A. S. Jafri, W. Tan, S. S. Hu, J. Zhongping, D. Treeprasertsuk, S. Lee, G. H. Ghazinyan, H. Lesmana, L. A. Sood, A. M | Hepatol Int | 2021 |
*Acute-On-Chronic Liver Failure |
| Evaluation of the impact of cataract surgery on cognitive function in very elderly patients: a prospective, observational study | Verdina, T. Stiro, F. Bruni, F. Spedicato, G. A. Mastropasqua, R. Cavallini, G. M. | Aging Clin Exp Res | 2021 |
6-item cognitive impairment test (6CIT) |
| Physiological Assessment of Delirium Severity: The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S) | van Sleuwen, M. Sun, H. Eckhardt, C. Neelagiri, A. Tesh, R. A. Westmeijer, M. Paixao, L. Rajan, S. Velpula Krishnamurthy, P. Sikka, P. Leone, M. J. Panneerselvam, E. Quadri, S. A. Akeju, O. Kimchi, E. Y. Westover, M. B. | Crit Care Med | 2021 |
van Sleuwen, M. |
| The effect of peri-operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non-cardiac surgical patients: a randomised, double-blind placebo-controlled trial | van Norden, J. Spies, C. D. Borchers, F. Mertens, M. Kurth, J. Heidgen, J. Pohrt, A. Mueller, A. | Anaesthesia | 2021 |
Aged |
| Rivastigmine for minor visual hallucinations in Parkinson's disease: A randomized controlled trial with 24 months follow-up | van Mierlo, T. J. M. Foncke, E. M. J. Post, B. Schmand, B. A. Bloem, B. R. van Harten, B. Tissingh, G. Munts, A. G. de Haan, R. J. de Bie, R. M. A. | Brain Behav | 2021 |
Cholinesterase Inhibitors |
| Effects of Orthogeriatric Care Models on Outcomes of Hip Fracture Patients: A Systematic Review and Meta-Analysis | Van Heghe, A. Mordant, G. Dupont, J. Dejaeger, M. Laurent, M. R. Gielen, E. | Calcif Tissue Int | 2021 |
Geriatric co-management |
| Automatic continuous EEG signal analysis for diagnosis of delirium in patients with sepsis | Urdanibia-Centelles, O. Nielsen, R. M. Rostrup, E. Vedel-Larsen, E. Thomsen, K. Nikolic, M. Johnsen, B. Møller, K. Lauritzen, M. Benedek, K. | Clin Neurophysiol | 2021 |
Automatic EEG |
| Evaluation of the effectiveness of delirium prevention care protocol for the patients with hip fracture: A randomised controlled study | Unal, N. Guvenc, G. Ilkin Naharci, M. | J Clin Nurs | 2021 |
nursing care |
| Association of poor sleep burden in middle age and older adults with risk for delirium during hospitalization | Ulsa, M. C. Zheng, X. Li, P. Gaba, A. Wong, P. M. Saxena, R. Scheer, F. Rutter, M. Akeju, O. Hu, K. Gao, L. | J Gerontol A Biol Sci Med Sci | 2021 |
Sleep health |
| Where should patients with or at risk of delirium be treated in an acute care system? Comparing the rates of delirium in patients receiving usual care vs alternative care: A systematic review and meta-analysis | Ukwuoma Ekeozor, C. Jeyaruban, D. Lasserson, D. | Int J Clin Pract | 2021 |
Critical Care |
| Restraint use in the acute-care hospital setting: A cross-sectional multi-centre study | Thomann, S. Zwakhalen, S. Richter, D. Bauer, S. Hahn, S. | Int J Nurs Stud | 2021 |
Cross-Sectional Studies |
| Immune, Blood Cell, and Blood Gas Biomarkers of Delirium in Elderly Individuals with Hip Fracture Surgery | Thisayakorn, P. Tangwongchai, S. Tantavisut, S. Thipakorn, Y. Sukhanonsawat, S. Wongwarawipat, T. Sirivichayakul, S. Maes, M. | Dement Geriatr Cogn Disord | 2021 |
Delirium |
| Delirium Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS) | Teng, C. Frei, C. R. | Drugs Real World Outcomes | 2021 |
Delirium, Antibiotics, FDA Adverse Event Reporting System |
| The Impact of Aging on Symptom Prevalence and Management in Terminally ill Patients With Cancer | Tatokoro, M. Matsuo, N. | J Pain Symptom Manage | 2021 |
Age |
| Subjective strain of care experienced by pulmonary and critical care medical nurses when caring for patients with delirium: a cross-sectional study | Tan, H. Zhou, L. Wu, S. Dong, Q. Yang, L. Xu, J. Zhao, S. Wang, X. Yang, H. | BMC Health Serv Res | 2021 |
Critical Care |
| Circulating MicroRNAs and Novel Proteins as Potential Biomarkers of Neurological Complications after Heart Bypass Surgery | Szwed, K. Szwed, M. Kozakiewicz, M. Karłowska-Pik, J. Soja-Kukieła, N. Bartoszewska, A. Borkowska, A. | J Clin Med | 2021 |
Cabg |
| Evaluation of the implementation of multidisciplinary fast-track program for acute geriatric hip fractures at a University Hospital in resource-limited settings | Sura-Amonrattana, U. Tharmviboonsri, T. Unnanuntana, A. Tantigate, D. Srinonprasert, V. | BMC Geriatr | 2021 |
Aged |
| Perceptions of current occupational therapy practice with older adults experiencing delirium | Strecker, C. Hitch, D. | Australas J Ageing | 2021 |
Aged |
| Changes in autonomic tone during delirium in acute stroke patients assessed by pupillometry and skin conductance | Stokholm, J. Birkmose, L. K. H. Ahmed, Aabo Csillag, C. Kjær, T. W. Christensen, T. | J Neurol Sci | 2021 |
Autonomic Nervous System |
| Expression of HO1 and PER2 can predict the incidence of delirium in trauma patients with concomitant brain injury | Steimer, M. Kaiser, S. Ulbrich, F. Kalbhenn, J. Bürkle, H. Schallner, N. | Sci Rep | 2021 |
Biomarkers, Circadian rhythms and sleep, Translational research, Neurological manifestations |
| An implementation science approach to geriatric screening in an emergency department | Southerland, L. T. Hunold, K. M. Van Fossen, J. Caterino, J. M. Gulker, P. Stephens, J. A. Bischof, J. J. Farrell, E. Carpenter, C. R. Mion, L. C. | J Am Geriatr Soc | 2021 |
Cfir |
| Effectiveness of the ABCDEF bundle on delirium, functional outcomes and quality of life in intensive care patients: a study protocol for a randomised controlled trial with embedded process evaluation | Sosnowski, K. Mitchell, M. Cooke, M. White, H. Morrison, L. Lin, F. | BMJ Open | 2021 |
Critical Care |
| Effects of general versus subarachnoid anaesthesia on circadian melatonin rhythm and postoperative delirium in elderly patients undergoing hip fracture surgery: A prospective cohort clinical trial | Song, Y. Liu, Y. Yuan, Y. Jia, X. Zhang, W. Wang, G. Jia, Y. Wang, X. Liu, L. Li, W. Li, X. Cai, N. Liu, C. Li, Y. Han, Y. Zhou, Y. Mi, X. Shi, C. Wang, J. Q. Vuylsteke, A. Guo, X. Li, Z. | EBioMedicine | 2021 |
Circadian rhythm |
| Comparison of the Effects of Haloperidol and Dexmedetomidine on Delirium and Agitation in Patients with a Traumatic Brain Injury Admitted to the Intensive Care Unit | Soltani, F. Tabatabaei, S. Jannatmakan, F. Nasajian, N. Amiri, F. Darkhor, R. Moravej, M. | Anesth Pain Med | 2021 |
Delirium |
| Comparison of postoperative delirium within 24 hours between ketamine and propofol infusion during cardiopulmonary bypass machine: A randomized controlled trial | Siripoonyothai, S. Sindhvananda, W. | Ann Card Anaesth | 2021 |
*Cardiac surgery |
| Improving delirium detection in intensive care units: Multicomponent education and training program | Sinvani, L. Delle Site, C. Laumenede, T. Patel, V. Ardito, S. Ilyas, A. Hertz, C. Wolf-Klein, G. Pekmezaris, R. Hajizadeh, N. Thomas, L. | J Am Geriatr Soc | 2021 |
critical care nursing |
| Outcome, demography and resource utilization in ICU Patients with delirium and malignancy | Sieber, M. Rudiger, A. Schüpbach, R. Krüger, B. Schubert, M. Bettex, D. | Sci Rep | 2021 |
Medical research, Oncology, Delirium, ICU delirium, ICDSC, Malignancies |
| Prevalence of postoperative delirium with different combinations of intraoperative general anesthetic agents in patients undergoing cardiac surgery: A retrospective propensity-score-matched study | Shin, H. J. Choi, S. L. Na, H. S. | Medicine (Baltimore) | 2021 |
Aged |
| Is Comprehensive Geriatric Assessment Admission Avoidance Hospital at Home an Alternative to Hospital Admission for Older Persons? : A Randomized Trial | Shepperd, S. Butler, C. Cradduck-Bamford, A. Ellis, G. Gray, A. Hemsley, A. Khanna, P. Langhorne, P. Mort, S. Ramsay, S. Schiff, R. Stott, D. J. Wilkinson, A. Yu, L. M. Young, J. | Ann Intern Med | 2021 |
Aged |
| Delirium and abnormal autonomic nervous system response to head-up tilt testing | Shanahan, E. Ryan, S. Leahy, A. Sheehy, T. Costelloe, A. Roy, A. Galvin, R. Peters, C. Lyons, D. O'Connor, M. | Exp Gerontol | 2021 |
Aged, 80 and over |
| Understanding frailty among older people living in old age homes and the community in Nepal: A cross-sectional study | Shah, R. Carandang, R. R. Shibanuma, A. Ong, K. I. C. Kiriya, J. Jimba, M. | PLoS One | 2021 |
Activities of Daily Living |
| Death in delirious palliative-care patients occurs irrespective of age: A prospective, observational cohort study of 229 delirious palliative-care patients | Seiler, A. Blum, D. Hertler, C. Schettle, M. Zipser, C. M. Bode, L. Gehrke, S. Ernst, J. Schubert, M. von Känel, R. Boettger, S. | Palliat Support Care | 2021 |
Aged |
| Delirium Variability is Influenced by the Sound Environment (DEVISE Study): How Changes in the Intensive Care Unit soundscape affect delirium incidence | Sangari, A. Emhardt, E. A. Salas, B. Avery, A. Freundlich, R. E. Fabbri, D. Shotwell, M. S. Schlesinger, J. J. | J Med Syst | 2021 |
Critical Care |
| Delirium in Intensive Care Units: Perceptions of Physicians and Nurses | Salameh, B. Al Razeeni, D. M. Mansor, K. Abdallah, J. M. Ayed, A. Salem, H. | Crit Care Nurs Q | 2021 |
Critical Care |
| How to deal with the consent of adults with cognitive impairment involved in European geriatric living labs? | Sacco, G. Noublanche, F. Blazek, F. Hue, C. Carballido, L. Asfar, M. Allain, P. Annweiler, C. | Philos Ethics Humanit Med | 2021 |
Aged |
| Management of preoperative pain in elderly patients with moderate to severe cognitive deficits and hip fracture: a retrospective, monocentric study in an orthogeriatric unit | Ruel, M. Boussat, B. Boudissa, M. Garnier, V. Bioteau, C. Tonetti, J. Pailhe, R. Gavazzi, G. Drevet, S. | BMC Geriatr | 2021 |
Aged |
| Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial | Rozemeijer, S. de Grooth, H. J. Elbers, P. W. G. Girbes, A. R. J. den Uil, C. A. Dubois, E. A. Wils, E. J. Rettig, T. C. D. van Zanten, A. R. H. Vink, R. van den Bogaard, B. Bosman, R. J. Oudemans-van Straaten, H. M. de Man, A. M. E. | Trials | 2021 |
Ascorbic Acid |
| Synergistic Impact of Systolic Blood Pressure and Perfusion Status on Mortality in Acute Heart Failure | Rossello, X. Bueno, H. Gil, V. Jacob, J. Martín-Sánchez, F. J. Llorens, P. Herrero Puente, P. Alquézar-Arbé, A. Espinosa, B. Raposeiras-Roubín, S. Müller, C. E. Mebazaa, A. Maggioni, A. P. Pocock, S. Chioncel, O. Miró, Ò | Circ Heart Fail | 2021 |
Acute Disease |
| The Impact of Nursing Delirium Preventive Interventions in the ICU: A Multicenter Cluster-randomized Controlled Clinical Trial | Rood, P. J. T. Zegers, M. Ramnarain, D. Koopmans, M. Klarenbeek, T. Ewalds, E. van der Steen, M. S. Oldenbeuving, A. W. Kuiper, M. A. Teerenstra, S. Adang, E. van Loon, L. M. Wassenaar, A. Vermeulen, H. Pickkers, P. van den Boogaard, M. | Am J Respir Crit Care Med | 2021 |
Aged |
| Heart rate variability and delirium in acute non-cardioembolic stroke: a prospective, cross-sectional, cohort study | Rollo, E. Marotta, J. Callea, A. Brunetti, V. Vollono, C. Scala, I. Imperatori, C. Frisullo, G. Broccolini, A. Della Marca, G. | Neurol Sci | 2021 |
Autonomic |
| The training needs of Korean intensive care unit nurses regarding delirium | Roh, Y. S. | Intensive Crit Care Nurs | 2021 |
Clinical Competence |
| Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people-results from a nested, longitudinal cohort study | Richardson, S. J. Lawson, R. Davis, D. H. J. Stephan, B. C. M. Robinson, L. Matthews, F. E. Brayne, C. Barnes, L. E. Taylor, J. P. Parker, S. G. Allan, L. M. | Age Ageing | 2021 |
Aged |
| Recurrent delirium over 12 months predicts dementia: results of the Delirium and Cognitive Impact in Dementia (DECIDE) study | Richardson, S. J. Davis, D. H. J. Stephan, B. C. M. Robinson, L. Brayne, C. Barnes, L. E. Taylor, J. P. Parker, S. G. Allan, L. M. | Age Ageing | 2021 |
Cognition |
| Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated With Postoperative Delirium | Rhee, J. Kuznetsov, A. McKay, T. Lyons, M. Houstis, N. Mekkonen, J. Ethridge, B. Ibala, R. Hahm, E. Gitlin, J. Guseh, J. S. Kitchen, R. Rosenzweig, A. Shaefi, S. Flaczyk, A. Qu, J. Akeju, O. | Front Aging Neurosci | 2021 |
*il-6 |
| Comparison of Esophagectomy outcomes between a National Center, a National Audit Collaborative, and an International database using the Esophageal Complications Consensus Group (ECCG) standardized definitions | Reynolds, J. V. Donlon, N. Elliott, J. A. Donohoe, C. Ravi, N. Kuppusamy, M. K. Low, D. E. | Dis Esophagus | 2021 |
Aged |
| Health Profiles, Health Services Use, and Transition to Dementia in Inpatients With Late-Life Depression and Other Mental Illnesses | Reppermund, S. Heintze, T. Srasuebkul, P. Trollor, J. N. | J Am Med Dir Assoc | 2021 |
Aged |
| A Survey of Nurses' Perspectives on Delirium Screening in Older Adult Medical Inpatients With Limited English Proficiency | Reppas-Rindlisbacher, C. Panov, E. D. Cuperfain, A. B. Rawal, S. | J Gerontol Nurs | 2021 |
Aged |
| Post-hospital falls incidence and risk factors among older adults: a systematic review and meta-analysis | Qian, X. X. Chen, Z. Fong, D. Y. T. Ho, M. Chau, P. H. | Age Ageing | 2021 |
incidence |
| The prevalence of serotonin syndrome in an intensive care unit: A prospective observational study | Prakash, S. Rathore, C. Rana, K. | J Crit Care | 2021 |
Adult |
| Associations of subclinical heart failure and atrial fibrillation with mild cognitive impairment: a cross-sectional study in a subclinical heart failure screening programme | Potter, E. L. Ramkumar, S. Wright, L. Marwick, T. H. | BMJ Open | 2021 |
Aged |
| A One-Day Prospective National Observational Study on Sedation-Analgesia of Patients with Brain Injury in French Intensive Care Units: The SEDA-BIP-ICU (Sedation-Analgesia in Brain Injury Patient in ICU) Study | Poignant, S. Vigué, B. Balram, P. Biais, M. Carillon, R. Cottenceau, V. Dahyot-Fizelier, C. Degos, V. Geeraerts, T. Jeanjean, P. Vega, E. Lasocki, S. Espitalier, F. Laffon, M. | Neurocrit Care | 2021 |
Brain injury |
| Risk factors and adverse clinical outcomes of postoperative delirium in Thai elderly patients: A prospective cohort study | Pipanmekaporn, T. Punjasawadwong, Y. Wongpakaran, N. Wongpakaran, T. Suwannachai, K. Chittawatanarat, K. Mueankwan, S. | Perspect Psychiatr Care | 2021 |
Aged |
| Multifaceted intervention including Facebook-groups to improve guideline-adherence in ICU: A quasi-experimental interrupted time series study | Petosic, A. Småstuen, M. C. Beeckman, D. Flaatten, H. Sunde, K. Wøien, H. | Acta Anaesthesiol Scand | 2021 |
agitation/sedation |
| Perioperative Optimization of Senior Health in Spine Surgery: Impact on Postoperative Delirium | Pernik, M. N. Deme, P. R. Nguyen, M. L. Aoun, S. G. Adogwa, O. Hall, K. Stewart, N. A. Dosselman, L. J. El Tecle, N. E. McDonald, S. R. Bagley, C. A. Wingfield, S. A. | J Am Geriatr Soc | 2021 |
Aged |
| Postoperative delirium mediates 180-day mortality in orthopaedic trauma patients | Pedemonte, J. C. Sun, H. Franco-Garcia, E. Zhou, C. Heng, M. Quraishi, S. A. Westover, B. Akeju, O. | Br J Anaesth | 2021 |
Aged |
| Evaluating Pain, Opioids, and Delirium in Critically Ill Older Adults | Pavone, K. J. Jablonski, J. Cacchione, P. Z. Polomano, R. C. Compton, P. | Clin Nurs Res | 2021 |
Aged |
| Optimizing the Recognition and Treatment of In-Hospital Stroke: Evaluation of the 2CAN Score | Parrino, C. R. Noles, A. Lalla, R. Mehndiratta, P. Phipps, M. Cronin, C. Cole, J. Wozniak, M. Yarbrough, K. Chaturvedi, S. | J Stroke Cerebrovasc Dis | 2021 |
Aged |
| Cohort Analysis of the Association of Delirium Severity with Cerebrospinal Fluid Amyloid-Tau-Neurodegeneration Pathologies | Parker, M. White, M. Casey, C. Kunkel, D. Bo, A. Blennow, K. Zetterberg, H. Pearce, R. A. Lennertz, R. Sanders, R. D. | J Gerontol A Biol Sci Med Sci | 2021 |
Biology of aging, Biomarkers, Dementia |
| The Delirium Observation Screening Scale: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy | Park, J. Jeong, E. Lee, J | Clin Nurs Res | 2021 |
*Delirium/diagnosis |
| Higher neutrophil-to-lymphocyte ratio, mean platelet volume, and platelet distribution width are associated with postoperative delirium in patients undergoing esophagectomy: a retrospective observational study | Oyama, T. Kinoshita, H. Takekawa, D. Saito, J. Kushikata, T. Hirota, K. | J Anesth | 2021 |
Esophagectomy |
| The predictive value of the 'VMS frail older patients' for adverse outcomes in geriatric inpatients | Oud, F. M. M. Wolzak, N. K. Spies, P. E. Zaag-Loonen, H. J. V. van Munster, B. C. | Arch Gerontol Geriatr | 2021 |
Aged |
| Impact of ABCDE Bundle Implementation in the Intensive Care Unit on Specific Patient Costs | Otusanya, O. T. Hsieh, S. J. Gong, M. N. Gershengorn, H. B. | J Intensive Care Med | 2021 |
cost and cost analysis |
| Use of Suvorexant and Antipsychotics in the Treatment of Delirium After Infectious Diseases: A Retrospective Study | Okino, K. Yamada, H. Tomioka, H. Nozaki, S. Iwanami, A. Inamoto, A. | J Clin Psychopharmacol | 2021 |
Antipsychotics, Suvorexant, Delirium, Infectious Disease, C-reactive protein, White blood cell count |
| The assessment of risk factors for postoperative delirium using cubic spline curves in gastroenterological surgery | Okawa, Y. Tanaka, K. Nakanishi, Y. Asano, T. Noji, T. Ebihara, Y. Kurashima, Y. Nakamura, T. Murakami, S. Tsuchikawa, T. Okamura, K. Shichinohe, T. Hirano, S. | Surg Today | 2021 |
Cubic spline curve |
| Delirium and Long-Term Outcomes among Survivors of Extracorporeal Membrane Oxygenation Therapy: A Nationwide Cohort Study in South Korea | Oh, T. K. Park, H. Y. Song, I. A. | J Intensive Care Med | 2021 |
Critical Care |
| The Impact of Earplugs and Eye Masks on Sleep Quality in Surgical ICU Patients at Risk for Frequent Awakenings | Obanor, O. O. McBroom, M. M. Elia, J. M. Ahmed, F. Sasaki, J. D. Murphy, K. M. Chalk, S. Menard, G. A. Pratt, N. V. Venkatachalam, A. M. Romito, B. T. | Crit Care Med | 2021 |
Adult |
| Interventions to support recovery following an episode of delirium: A realist synthesis | O'Rourke, G. Parker, D. Anderson, R. Morgan-Trimmer, S. Allan, L | Aging Ment Health | 2021 |
Aged |
| Preoperative inflammatory mediators and postoperative delirium: systematic review and meta-analysis | Noah, A. M. Almghairbi, D. Evley, R. Moppett, I. K. | Br J Anaesth | 2021 |
Aged |
| Development of an algorithm for assessing fall risk in a Japanese inpatient population | Nakanishi, T. Ikeda, T. Nakamura, T. Yamanouchi, Y. Chikamoto, A. Usuku, K. | Sci Rep | 2021 |
Disease prevention, Geriatrics, Public health |
| Relationship among melatonin, postoperative delirium, and postoperative cognitive dysfunction | Mu, S. Wu, Y. Wu, A. | Ann Palliat Med | 2021 |
*Cognition Disorders |
| Hospital complications among older adults: Better processes could reduce the risk of delirium | Moura Junior, V. Westover, M. B. Li, F. Kimchi, E. Kennedy, M. Benson, N. M. Moura, L. M. Hsu, J. | Health Serv Manage Res | 2021 |
access/demand/utilization of services |
| Precipitated Withdrawal, Delirium, and Cerebellar Stroke: The Pharmacology of Buprenorphine Induction in Non-pharmaceutical Fentanyl and the Neuropsychiatric Manifestations of Cerebellar Stroke | Montalvo, C. von Horn, A. Lane, C. E. Weinstein, Z. M. Sharma, M. Suzuki, J. | Harv Rev Psychiatry | 2021 | |
| The effect of foot massage on the level of consciousness and delirium of intensive care patients: A randomized single-blind controlled trial | Momeni, M. Arab, M. Dehghan, M. Ahmadinejad, M. | J Bodyw Mov Ther | 2021 |
*Consciousness |
| Intravenous patient-controlled analgesia does not increase the risk of postoperative delirium compared to patient-controlled epidural analgesia: a propensity score-matched retrospective cohort study | Miyoshi, H. Nakamura, R. Noda, Y. Yokomi, H. Kamiya, S. Morio, A. Watanabe, T. Narasaki, S. Toyota, Y. Saeki, N. Hamada, H. Tsutsumi, Y. M. | Ann Palliat Med | 2021 |
Patient-controlled analgesia (PCA) |
| Standardized Semistructured Psychosocial Evaluation Before Stem Cell Transplantation Predicts Delirium After Transplant | Mishkin, A. D. Schmajuk, M. Reshef, R. Lopez-Pintado, S. Mapara, M. Y. Shapiro, P. A. | J Acad Consult Liaison Psychiatry | 2021 |
*cancer (PSY0140) |
| Pattern of Brain Injury in Patients With Thrombotic Thrombocytopenic Purpura in the Precaplacizumab Era | Mirouse, A. Legriel, S. Dumas, G. Labro, G. Veyradier, A. Zafrani, L. Valade, S. Hourmant, Y. Boutboul, D. Darmon, M. Coppo, P. Mariotte, E. Azoulay, E. | Crit Care Med | 2021 |
Adult |
| Postoperative delirium is a risk factor for complications and poor outcome after total hip and knee arthroplasty | Meyer, M. Götz, J. Parik, L. Renkawitz, T. Grifka, J. Maderbacher, G. Kappenschneider, T. Weber, M. | Acta Orthop | 2021 |
Geriatrics, Surgery, Postoperative delirium, Elective joint replacement |
| Why should you stay one night? Prospective observational study of enhanced recovery in elderly patients | Melegari, G. Albertini, G. Romani, A. Malaguti, S. Traccitto, F. Giuliani, E. Cavallini, G. M. Bertellini, E. Barbieri, A. | Aging Clin Exp Res | 2021 |
Aged |
| Inhaled isoflurane via the anaesthetic conserving device versus propofol for sedation of invasively ventilated patients in intensive care units in Germany and Slovenia: an open-label, phase 3, randomised controlled, non-inferiority trial | Meiser, A. Volk, T. Wallenborn, J. Guenther, U. Becher, T. Bracht, H. Schwarzkopf, K. Knafelj, R. Faltlhauser, A. Thal, S. C. Soukup, J. Kellner, P. Drüner, M. Vogelsang, H. Bellgardt, M. Sackey, P. | Lancet Respir Med | 2021 |
Isoflurane, ICU, Propofol, Invasive ventilation, RASS |
| Perioperative Considerations for Patients with a Known Diagnosis of Dementia | McSwain, J. R. Sirianni, J. M. Wilson, S. H. | Adv Anesth | 2021 |
Alzheimer’s dementia |
| The relationship between frailty and delirium: insights from the 2017 Delirium Day study | Mazzola, P. Tassistro, E. Di Santo, S. Rossi, E. Andreano, A. Valsecchi, M. G. Cherubini, A. Marengoni, A. Mossello, E. Bo, M. Inzitari, M. Di Bari, M. Udina, C. Latronico, N. Paolillo, C. Morandi, A. Bellelli, G. | Age Ageing | 2021 |
Aged |
| Absence of Longer Reorientation Times in Patients Undergoing Electroconvulsive Therapy and Concomitant Treatment with Lithium | Martins-Ascencao, R. Rodrigues-Silva, N. Trovão, N. | Clin Psychopharmacol Neurosci | 2021 |
Cognitive dysfunction |
| Period-Prevalence and Risk Factors for Delirium in a Tertiary Referral ICU: A prospective cohort study | Martinez, F. E. Ho, V. W. Brogan, G. Pickering, C. Leung, G. Parrey, J. Charlton, A. | Acute Med | 2021 |
Adult |
| Cross-Cultural Adaptation and Validation of the Italian Version of the Observational Scale of Level of Arousal | Martella, L. A. Carmisciano, L. Giannotti, C. Signori, A. Pontremoli, R. Giusti, M. Gualco, E. Beccati, V. Marengoni, A. Nencioni, A. Monacelli, F. | J Am Med Dir Assoc | 2021 |
Aged |
| Prevalence and management of delirium in community dwelling older people with dementia referred to a memory clinic | Manni, B. Federzoni, L. Zucchi, P. Mussi, C. Inzitari, M. Carda, C. A. Fabbo, A. Morandi, A. | Aging Clin Exp Res | 2021 |
Aged |
| Impact of a Real-Time, Pharmacist-Led, Intensive Care Unit-Based Feedback Intervention on Analgesia and Sedation Quality Among Mechanically Ventilated Patients | Mancheril, B. Kram, B. Schultheis, J. Kram, S. Trammel, M. Liu, B. Jordan, W. Cox, C. E. | J Nurs Care Qual | 2021 |
*Analgesia |
| A New ICU Delirium Prevention Bundle to Reduce the Incidence of Delirium: A Randomized Parallel Group Trial | Malik, A. K. Baidya, D. K. Anand, R. K. Subramaniam, R. | Indian J Crit Care Med | 2021 |
Delirium |
| Risk factors associated with the development of delirium in general ICU patients. A prospective observational study | Lobo-Valbuena, B. Gordo, F. Abella, A. Garcia-Manzanedo, S. Garcia-Arias, M. M. Torrejón, I. Varillas-Delgado, D. Molina, R. | PLoS One | 2021 |
Delirium, ICU Delirium, CAM-ICU, Clinical Frailty Scale, Length of stay, Readmission rate |
| Incidence, Predictors and Outcomes of Delirium in Complicated Type B Aortic Dissection Patients After Thoracic Endovascular Aortic Repai | Liu, J. Yang, F. Luo, S. Li, C. Liu, W. Liu, Y. Huang, W. Xie, E. Chen, L. Su, S. Yang, X. Geng, Q. Luo, J. | Clin Interv Aging | 2021 |
*Aneurysm, Dissecting/surgery |
| Dynamic Delirium Severity Trajectories and Their Association With 2-Year Healthcare Utilization and Mortality Outcomes | Lindroth, H. Mohanty, S. Ortiz, D. Gao, S. Perkins, A. J. Khan, S. H. Boustani, M. A. Khan, B. A. | Crit Care Explor | 2021 |
delirium |
| Intraoperative Oxygen Concentration and Postoperative Delirium After Laparoscopic Gastric and Colorectal Malignancies Surgery: A Randomized, Double-Blind, Controlled Trial | Lin, X. Wang, P. Liu, D. W. Guo, Y. W. Xie, C. H. Wang, B. Dong, R. Sun, L. X. Wang, M. S. Bi, Y. L. | Clin Interv Aging | 2021 |
Aged |