What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Melatonin to prevent delirium in patients with advanced cancer: a double blind, parallel, randomized, controlled, feasibility trial
- Authors
- Lawlor, P. G. McNamara-Kilian, M. T. MacDonald, A. R. Momoli, F. Tierney, S. Lacaze-Masmonteil, N. Dasgupta, M. Agar, M. Pereira, J. L. Currow, D. C. Bush, S. H.
- Year
- 2020
- Journal
- BMC Palliat Care
- Abstract
BACKGROUND: Delirium is highly problematic in palliative care (PC). Preliminary data indicate a potential role for melatonin to prevent delirium, but no randomized controlled trials (RCTs) are reported in PC. METHODS: Patients aged ≥18 years, with advanced cancer, admitted to an inpatient Palliative Care Unit (PCU), having a Palliative Performance Scale rating ≥ 30%, and for whom consent was obtained, were included in the study. Patients with delirium on admission were excluded. The main study objectives were to assess the feasibility issues of conducting a double-blind RCT of exogenous melatonin to prevent delirium in PC: recruitment, retention, procedural acceptability, appropriateness of outcome measures, and preliminary efficacy and safety data. Study participants were randomized in a double-blind, parallel designed study to receive daily melatonin 3 mg or placebo orally at 21:00 over 28 days or less if incident delirium, death, discharge or withdrawal occurred earlier. Delirium was diagnosed using the Confusion Assessment Method. Efficacy endpoints in the melatonin and placebo groups were compared using time-to-event analysis: days from study entry to onset of incident delirium. RESULTS: Over 16 months, 60/616 (9.7%; 95% CI: 7.5-12.4%) screened subjects were enrolled. The respective melatonin (n = 30) vs placebo (n = 30) outcomes were: incident delirium in 11/30 (36.7%; 95%CI: 19.9-56.1%) vs 10/30 (33%; 95% CI: 17.3-52.8%); early discharge (6 vs 5); withdrawal (6 vs 3); death (0 vs 1); and 7 (23%) vs 11 (37%) reached the 28-day end point. The 25th percentile time-to-event were 9 and 18 days (log rank, χ(2) = 0.62, p = 0.43) in melatonin and placebo groups, respectively. No serious trial medication-related adverse effects occurred and the core study procedures were acceptable. Compared to those who remained delirium-free during their study participation, those who developed delirium (n = 21) had poorer functional (p = 0.036) and cognitive performance (p = 0.013), and in particular, poorer attentional capacity (p = 0.003) at study entry. CONCLUSIONS: A larger double-blind RCT is feasible, but both subject accrual and withdrawal rates signal a need for multisite collaboration. The apparent trend for shorter time to incident delirium in the melatonin group bodes for careful monitoring in a larger trial. TRIAL REGISTRATION: Registered on July 21st 2014 with ClinicalTrials.gov : NCT02200172 .
- PMID
- Keywords
Advanced cancer
Delirium
Feasibility study
Melatonin
Pilot
Prevention
Randomized controlled trial
Sleep
- Page(s)
- 163
- Volume
- 19
- Issue
- 1
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Implementation of ABCDEF care bundle in intensive care units: A cross-sectional survey | Liang, S. Chau, J. P. C. Lo, S. H. S. Li, S. Gao, M. | Nurs Crit Care | 2021 |
ABCDEF care bundle |
| Lymphocyte and NK Cell Counts Can Predict Sepsis-Associated Delirium in Elderly Patients | Li, D. Zhang, J. Bai, G. Chen, J. Cheng, W. Cui, N. | Front Aging Neurosci | 2021 |
NK cell |
| Safety and Efficacy of Dexmedetomidine in Acutely Ill Adults Requiring Noninvasive Ventilation: A Systematic Review and Meta-analysis of Randomized Trials | Lewis, K. Piticaru, J. Chaudhuri, D. Basmaji, J. Fan, E. Møller, M. H. Devlin, J. W. Alhazzani, W. | Chest | 2021 |
dexmedetomidine |
| Pharmacological strategies to prevent postoperative delirium: a systematic review and network meta-analysis | Lee, J. M. Cho, Y. J. Ahn, E. J. Choi, G. J. Kang, H. | Anesth Pain Med (Seoul) | 2021 |
Delirium |
| Evaluation of Melatonin Practices for Delirium in Pediatric Critically Ill Patients | Laudone, T. W. Beck, S. D. Lahr, H. J. | J Pediatr Pharmacol Ther | 2021 |
antipsychotic |
| Results from a double blinded, randomised, placebo-controlled, feasibility trial of melatonin for the treatment of delirium in older medical inpatients | Lange, P. W. Clayton-Chubb, D. I. Watson, R. Maier, A. B. | Intern Med J | 2021 |
Aged |
| Delirium, Cerebral Perfusion, and High-Frequency Vital-Sign Monitoring in the Critically Ill. The CONFOCAL-2 Feasibility Study | Khan, J. M. Wood, M. D. Lee, K. F. H. Maslove, D. Muscedere, J. English, S. W. Ball, I. Slessarev, M. Boyd, J. G. | Ann Am Thorac Soc | 2021 |
cerebral oxygenation |
| Preoperative brain MRI features and occurrence of postoperative delirium | Kant, I. M. J. de Bresser, J. van Montfort, S. J. T. Mutsaerts, Hjmm Witkamp, T. D. Buijsrogge, M. Spies, C. Hendrikse, J. Slooter, A. J. C. | J Psychosom Res | 2021 |
Aged |
| Intraoperative monitoring parameters and postoperative delirium: Results of a prospective cross-sectional trial | Jung, C. Hinken, L. Fischer-Kumbruch, M. Trübenbach, D. Fielbrand, R. Schenk, I. Diegmann, O. Krauß, T. Scheinichen, D. Schultz, B. | Medicine (Baltimore) | 2021 |
Adult |
| Development of the AL-O-A Score for Delirium Screening in Acute Internal Medicine: a Monocentric Prospective Study | John, G. Bovet, V. Verdon, V. Zender, H. Donzé, J. | J Gen Intern Med | 2021 |
adult |
| Intravenous Iron in a Prehabilitation Program for Older Surgical Patients: Prospective Cohort Study | Janssen, T. L. Steyerberg, E. W. van Gammeren, A. J. Ho, G. H. Gobardhan, P. D. van der Laan, L. | J Surg Res | 2021 |
Abdomen/surgery |
| Comparative associations between anticholinergic burden and emergency department visits for anticholinergic adverse events in older Korean adults: a nested case-control study using national claims data for validation of a novel country-specific scale | Hwang, S. Chung, J. E. Jun, K. Ah, Y. M. Kim, K. I. Lee, J. Y. | BMC Pharmacol Toxicol | 2021 |
Anticholinergic syndromes |
| Evaluation of QTc Interval Effects of Antipsychotic Medications for Intensive Care Unit Delirium in Pediatric Patients | Hutchins, L. M. Shipman, A. Zimmerman, K. O. Heath, T. S. | J Pediatr Pharmacol Ther | 2021 |
QTc interval prolongation |
| Implementing a Rapid, Two-Step Delirium Screening Protocol in Acute Care: Barriers and Facilitators | Husser, E. K. Fick, D. M. Boltz, M. Shrestha, P. Siuta, J. Malloy, S. Overstreet, A. Leslie, D. L. Ngo, L. Jung, Y. Inouye, S. K. Marcantonio, E. R. | J Am Geriatr Soc | 2021 |
delirium |
| Higher versus lower mean arterial pressure target management in older patients having non-cardiothoracic surgery: A prospective randomized controlled trial | Hu, A. M. Qiu, Y. Zhang, P. Zhao, R. Li, S. T. Zhang, Y. X. Zheng, Z. H. Hu, B. L. Yang, Y. L. Zhang, Z. J. | J Clin Anesth | 2021 |
Elderly patients |
| Personalized Blood Pressure Management During Cardiac Surgery With Cerebral Autoregulation Monitoring: A Randomized Trial | Hogue, C. W. Brown, C. H. th Hori, D. Ono, M. Nomura, Y. Balmert, L. C. Srdanovic, N. Grafman, J. Brady, K. | Semin Thorac Cardiovasc Surg | 2021 |
Blood pressure |
| Clinical Features and Outcomes of Patients with Dementia Compared to an Aging Cohort Hospitalized During the Initial New York City COVID-19 Wave | Harb, A. A. Chen, R. Chase, H. S. Natarajan, K. Noble, J. M. | J Alzheimers Dis | 2021 |
Aged |
| Perioperative Multidisciplinary Delirium Prevention: A Longitudinal Case Report | Hamlet, K. M. Pasternak, E. Rabai, F. Mufti, M. Hernaiz Alonso, C. Price, C. C. | A A Pract | 2021 | |
| Cerebrospinal Fluid Concentration of Neurogranin in Hip Fracture Patients with Delirium | Halaas, N. B. Zetterberg, H. Idland, A. V. Knapskog, A. B. Watne, L. O. Blennow, K. | J Alzheimers Dis | 2021 |
Alzheimer’s disease |
| A retrospective study of factors associated with persistent delirium | Goto, H. Yamauchi, T. Okumura, K. Matsuoka, K. Toritsuka, M. Yasuno, F. Uemura, H. Kuki, K. Makinodan, M. Kishimoto, T. | Psychogeriatrics | 2021 |
Case-Control Studies |
| Association Between Early Tracheostomy and Delirium in Older Adults in the United States | Gazda, A. J. Kwak, M. J. Jani, P. Dinh, K. Hussain, R. Dronavalli, G. Warner, M. Salas De Armas, I. Kumar, S. Nathan, S. Kar, B. Gregoric, I. D. Patel, B. Akkanti, B. | J Cardiothorac Vasc Anesth | 2021 |
delirium |
| Poor outcomes of delirium in the intensive care units are amplified by increasing age: A retrospective cohort study | Gao, W. Zhang, Y. P. Jin, J. F. | World J Emerg Med | 2021 |
Aging |
| Postoperative Delirium is Associated With Prolonged Head and Neck Resection and Reconstruction Surgery: An Institutional Study | Edwards, D. A. Medhavy, A. Hoffman, O. G. Hoffman, G. R. | J Oral Maxillofac Surg | 2021 |
Aged |
| Delirium Assessment in Critically Ill Older Adults: Considerations During the COVID-19 Pandemic | Duggan, M. C. Van, J. Ely, E. W. | Crit Care Clin | 2021 |
Aged |
| Delirium occurrence in older Irish adults admitted to an acute medical hospital: a prospective cohort study | Dolan, C. Mohd Zubir, M. Melvin, V. McCarthy, G. Meagher, D. Adamis, D. | Ir J Psychol Med | 2021 |
Delirium |
| Clinical utility of brain computed tomography in prediction of post-stroke delirium | Czyzycki, M. Glen, A. Slowik, A. Chrzan, R. Dziedzic, T. | J Neural Transm (Vienna) | 2021 |
Brain atrophy |
| Risk factors for long-term cognitive impairment in ICU survivors: A multicenter, prospective cohort study | Collet, M. O. Egerod, I. Thomsen, T. Wetterslev, J. Lange, T. Ebdrup, B. H. Perner, A. | Acta Anaesthesiol Scand | 2021 | |
| Integration of family caregivers in delirium prevention care for hospitalized older adults: A case study analysis | Cohen, C. Pereira, F. Kampel, T. Bélanger, L. | J Adv Nurs | 2021 |
Aged |
| Investigating how electroencephalogram measures associate with delirium: A systematic review | Boord, M. S. Moezzi, B. Davis, D. Ross, T. J. Coussens, S. Psaltis, P. J. Bourke, A. Keage, H. A. D. | Clin Neurophysiol | 2021 |
Delirium |
| Pharmacologic Management of Intensive Care Unit Delirium: Clinical Prescribing Practices and Outcomes in More Than 8500 Patient Encounters | Boncyk, C. S. Farrin, E. Stollings, J. L. Rumbaugh, K. Wilson, J. E. Marshall, M. Feng, X. Shotwell, M. S. Pandharipande, P. P. Hughes, C. G. | Anesth Analg | 2021 | |
| Predictors of delirium in older patients at the emergency department: a prospective multicentre derivation study | Béland, E. Nadeau, A. Carmichael, P. H. Boucher, V. Voyer, P. Pelletier, M. Gouin, É Daoust, R. Berthelot, S. Lamontagne, M. E. Morin, M. Lemire, S. Vu, T. T. M. Émond, M. | CJEM | 2021 |
Delirium |
| Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort | Atkins, J. L. Pilling, L. C. Heales, C. J. Savage, S. Kuo, C. L. Kuchel, G. A. Steffens, D. C. Melzer, D. | J Alzheimers Dis | 2021 |
Cohort |
| Awareness of Delirium by ICU Nurses | Asmar, I. T. Yaseen, K. S. Jaghama, M. K. Khawaja, Y. F. Alwredat, A. A. Sadaqa, M. H. | Crit Care Nurs Q | 2021 | |
| Psychiatric Clinical Profiles and Pharmacological Interactions in COVID-19 Inpatients Referred to a Consultation Liaison Psychiatry Unit: a Cross-Sectional Study | Arbelo, N. López-Pelayo, H. Sagué, M. Madero, S. Pinzón-Espinosa, J. Gomes-da-Costa, S. Ilzarbe, L. Anmella, G. Llach, C. D. Imaz, M. L. Cámara, M. M. Pintor, L. | Psychiatr Q | 2021 |
Covid-19 |
| Octogenarian patients' sleep and delirium experiences in hospital and four years after aortic valve replacement: a qualitative interview study | Amofah, H. A. Broström, A. Instenes, I. Fridlund, B. Haaverstad, R. Kuiper, K. Ranhoff, A. H. Norekvål, T. M. | BMJ Open | 2021 |
Aged, 80 and over |
| Delirium and quality of life in critically ill patients: a prospective cohort study | Luz, L. F. D. S. Santos, M. C. D. Ramos, T. A. Almeida, C. B. Rover, M. C. Dal'Pizzol, C. P. Pohren, C. L. D. S. Martins, A. V. D. S. Boniatti, M. M. | Rev Bras Ter Intensiva | 2020 |
adult |
| Bispectral Index Monitoring With Density Spectral Array for Delirium Detection | Luo, A. Muraida, S. Pinchotti, D. Richardson, E. Ye, E. Hollingsworth, B. Win, A. Myers, O. Langsjoen, J. Valles, E. Zolyomi, A. Quinn, D. K. | Psychosomatics | 2020 |
bispectral index monitoring |
| Delirium prediction in the intensive care unit: a temporal approach | Lucini, F. R. Fiest, K. M. Stelfox, H. T. Lee, J. | Annu Int Conf IEEE Eng Med Biol Soc | 2020 |
Alberta |
| Impact of place of residence, frailty and other factors on rehabilitation outcomes post hip fracture | Low, S. Wee, E. Dorevitch, M. | Age Ageing | 2020 |
clinical frailty scale |
| Ramelteon for Decreasing Delirium in Surgical Intensive Care Unit Patients | Lopez, C. N. Fuentes, A. Dhala, A. Balk, J. | Clinical Medicine Insights: Psychiatry | 2020 |
haloperidol |
| Different depths of sedation versus risk of delirium in adult mechanically ventilated patients: A systematic review and meta-analysis | Long, L. Ren, S. Gong, Y. Zhao, H. He, C. Shen, L. Zhao, H. Ma, P. | PLoS One | 2020 |
Adult |
| Association of Troponin Levels With Mortality in Italian Patients Hospitalized With Coronavirus Disease 2019: Results of a Multicenter Study | Lombardi, C. M. Carubelli, V. Iorio, A. Inciardi, R. M. Bellasi, A. Canale, C. Camporotondo, R. Catagnano, F. Dalla Vecchia, L. A. Giovinazzo, S. Maccagni, G. Mapelli, M. Margonato, D. Monzo, L. Nuzzi, V. Oriecuia, C. Peveri, G. Pozzi, A. Provenzale, G. S | JAMA Cardiol | 2020 |
Aged |
| Role of dexmedetomidine in the treatment of delirium in critically ill patients: a systematic review and meta-analysis | Liu, X. Xiong, J. Tang, Y. Gong, C. C. Wang, D. F. | Minerva anestesiologica | 2020 |
adult |
| Delirium Severity Trajectories and Outcomes in ICU Patients. Defining a Dynamic Symptom Phenotype | Lindroth, H. Khan, B. A. Carpenter, J. S. Gao, S. Perkins, A. J. Khan, S. H. Wang, S. Jones, R. N. Boustani, M. A. | Ann Am Thorac Soc | 2020 |
critical care |
| Risk factors for postoperative delirium in patients with triple-branched stent graft implantation | Lin, Y. Chen, Q. Zhang, H. Chen, L. W. Peng, Y. Huang, X. Chen, Y. Li, S. Lin, L. | J Cardiothorac Surg | 2020 |
Apache |
| Cerebrospinal fluid cholinergic biomarkers are associated with postoperative delirium in elderly patients undergoing Total hip/knee replacement: a prospective cohort study | Lin, X. Tang, J. Liu, C. Li, X. Cao, X. Wang, B. Dong, R. Xu, W. Yu, X. Wang, M. Bi, Y. | BMC Anesthesiol | 2020 |
Cerebrospinal fluid |
| Effect of Dexmedetomidine on Delirium in Elderly Surgical Patients: A Meta-analysis of Randomized Controlled Trials | Lin, C. Tu, H. Jie, Z. Zhou, X. Li, C. | Ann Pharmacother | 2020 |
delirium |
| The relationship between intraoperative cerebral oximetry and postoperative delirium in patients undergoing off-pump coronary artery bypass graft surgery: a retrospective study | Lim, L. Nam, K. Lee, S. Cho, Y. J. Yeom, C. W. Jung, S. Moon, J. Y. Jeon, Y. | BMC Anesthesiol | 2020 |
Cerebral oximetry |
| Effects of nonpharmacological delirium-prevention interventions on critically ill patients' clinical, psychological, and family outcomes: A systematic review and meta-analysis | Liang, S. Chau, J. P. C. Lo, S. H. S. Zhao, J. Choi, K. C. | Aust Crit Care | 2020 |
Delirium |
| Validation of PREdiction of DELIRium in ICu patients (PRE-DELIRIC) among patients in intensive care units: A retrospective cohort study | Liang, S. Chau, J. P. C. Lo, S. H. S. Bai, L. Yao, L. Choi, K. C. | Nurs Crit Care | 2020 |
Icu |
| Prognostic Impact of Delirium in Older People With/Without Dementia: A Retrospective Cohort Study in Taiwan | Liang, C. K. Chuang, H. Y. Hsiao, F. Y. Chou, M. Y. Liu, T. Y. Yang, C. C. Chen, L. K. | Journal of Nutrition, Health and Aging | 2020 |
aged |
| Effects of modified version of the Hospital Elder Life Program on post-discharge cognitive function and activities of daily living among older adults undergoing total knee arthroplasty | Liang, C. K. Chu, C. S. Hsu, Y. H. Chou, M. Y. Wang, Y. C. Lin, Y. T. Renn, J. H. Liu, T. Y. Yang, C. C. | Arch Gerontol Geriatr | 2020 |
Cognitive decline |
| Incidence and Risk Factors for Delirium in Older Patients Following Intensive Care Unit Admission: A Prospective Observational Study | Li, X. Zhang, L. Gong, F. Ai, Y. | The journal of nursing research : JNR | 2020 |
aged |
| Surviving and Thriving 1 Year After Cardiac Surgery: Frailty and Delirium Matter | Li, H. C. Wei, Y. C. Hsu, R. B. Chi, N. H. Wang, S. S. Chen, Y. S. Chen, S. Y. Chen, C. C. H. Inouye, S. K. | Annals of Thoracic Surgery | 2020 |
ADL disability |
| Pharmacist Identification of Medication Therapy Problems Involving Cognition Among Older Adults Followed by a Home-Based Care Team | Levine, A. M. P. Emonds, E. E. Smith, M. A. Rickles, N. M. Kuchel, G. A. Steffens, D. C. Ohlheiser, A. Fortinsky, R. H. | Drugs and Aging | 2020 |
aged |
| Multicomponent Interventions for the Prevention of Delirium in Hospitalized Older People: A Meta-Analysis | León-Salas, B. Trujillo-Martín, M. M. Martínez Del Castillo, L. P. García-García, J. Pérez-Ros, P. Rivas-Ruiz, F. Serrano-Aguilar, P. | J Am Geriatr Soc | 2020 |
delirium |
| Pharmacologic interventions for prevention of delirium in hospitalized older people: A meta-analysis | León-Salas, B. Trujillo-Martín, M. M. Del Castillo, L. P. M. García, J. G. Pérez-Ros, P. Ruiz, F. R. Serrano-Aguilar, P. | Arch Gerontol Geriatr | 2020 |
Aged |
| "You've got to keep moving, keep going": Understanding older patients' experiences and perceptions of delirium and nonpharmacological delirium prevention strategies in the acute hospital setting | Lee-Steere, K. Liddle, J. Mudge, A. Bennett, S. McRae, P. Barrimore, S. E. | J Clin Nurs | 2020 |
Aged |
| The Effect of Intraoperative Magnesium Sulphate Infusion on Emergence Agitation after Ambulatory Ophthalmic Surgery in Children | Lee, Y. J. Kim, B. Y. Park, J. H. Kim, S. Y. Park, H. Y. Do, S. H. | J Clin Med | 2020 |
ambulatory surgery |
| Effects of the ABCDE bundle on the prevention of post-intensive care syndrome: A retrospective study | Lee, Y. Kim, K. Lim, C. Kim, J. S. | Journal of advanced nursing | 2020 |
adult |
| Effect of Antipsychotics and Non-Pharmacotherapy for the Management of Delirium in People Receiving Palliative Care | Lee, K. Y. Tan, E. C. K. Hanrahan, J. R. Chircop, C. Michael, F. Ong, J. A. | J Pain Palliat Care Pharmacother | 2020 |
Delirium |
| Effect of magnesium supplementation on emergence delirium and postoperative pain in children undergoing strabismus surgery: a prospective randomised controlled study | Lee, J. H. Choi, S. Lee, M. Jang, Y. E. Kim, E. H. Kim, J. T. Kim, H. S. | BMC Anesthesiol | 2020 |
Emergence delirium |
| Neurologic Complications in Patients With Cancer | Lee, E. Q. | Continuum (Minneapolis, Minn.) | 2020 |
adult |
| Melatonin to prevent delirium in patients with advanced cancer: a double blind, parallel, randomized, controlled, feasibility trial | Lawlor, P. G. McNamara-Kilian, M. T. MacDonald, A. R. Momoli, F. Tierney, S. Lacaze-Masmonteil, N. Dasgupta, M. Agar, M. Pereira, J. L. Currow, D. C. Bush, S. H. | BMC Palliat Care | 2020 |
Advanced cancer |
| Cognitive function and health-related quality of life 1 year after acute brain injury: An observational study | Larsen, L. K. Møller, K. Petersen, M. Egerod, I. | Acta Anaesthesiol Scand | 2020 |
Acute brain injury |
| The One-Two Punch of Delirium and Dementia During the COVID-19 Pandemic and Beyond | LaHue, S. C. Douglas, V. C. Miller, B. L. | Front Neurol | 2020 |
Alzheimer’s disease and related dementias (ADRD) |
| Postoperative Delirium is a Risk Factor of Poor Evolution Three Years After Cardiac Surgery: An Observational Cohort Study | Labaste, F. Porterie, J. Bousquet, P. Marcheix, B. Sanchez-Verlaan, P. Frances, B. Valet, P. Dray, C. Minville, V. | Clin Interv Aging | 2020 |
cardiac surgery |
| Delirium among Hospitalized Older Adults with Acute Heart Failure Exacerbation | Kwak, M. J. Avritscher, E. Holmes, H. M. Jantea, R. Flores, R. Rianon, N. Chung, T. H. Balan, P. Dhoble, A. | J Card Fail | 2020 |
Acute Heart Failure |
| Association between polypharmacy and the persistence of delirium: a retrospective cohort study | Kurisu, K. Miyabe, D. Furukawa, Y. Shibayama, O. Yoshiuchi, K. | Biopsychosoc Med | 2020 |
Classification and regression tree |
| Elevated Procalcitonin as a Risk Factor for Postoperative Delirium in the Elderly after Cardiac Surgery-A Prospective Observational Study | Kupiec, A. Adamik, B. Kozera, N. Gozdzik, W. | J Clin Med | 2020 |
cardiac surgery |
| The CAM-ICU-7 and ICDSC as measures of delirium severity in critically ill adult patients | Krewulak, K. D. Rosgen, B. K. Ely, E. W. Stelfox, H. T. Fiest, K. M. | PLoS One | 2020 |
Adult |
| Adaptation and Validation of a Chart-Based Delirium Detection Tool for the ICU (CHART-DEL-ICU) | Krewulak, K. D. Hiploylee, C. Ely, E. W. Stelfox, H. T. Inouye, S. K. Fiest, K. M. | J Am Geriatr Soc | 2020 |
Confusion Assessment Method for Intensive Care Unit (CAM-ICU) |
| Effectiveness of an intensive care unit family education intervention on delirium knowledge: a pre-test post-test quasi-experimental study | Krewulak, K. D. Bull, M. J. Wesley Ely, E. Davidson, J. E. Stelfox, H. T. Fiest, K. M. | Can J Anaesth | 2020 |
Critical care |
| Assessment and Management of Delirium in Critically Ill Veterans | Kresevic, D. M. Miller, D. Fuseck, C. W. Wade, M. Whitney, L. Conley, M. Rimac, J. Jacono, F. O'Leary-Wilson, H. L. Burant, C. J. | Critical care nurse | 2020 |
article |
| Delirium Post-Stroke: Short- and Long-Term Effect on Depression, Anxiety, Apathy and Aggression (Research Study-Part of PROPOLIS Study) | Kowalska, K. Droś, J. Mazurek, M. Pasińska, P. Gorzkowska, A. Klimkowicz-Mrowiec, A. | J Clin Med | 2020 |
aggression |
| Intrathecal Morphine Is Associated with Less Delirium Following Hip Fracture Surgery: A Register Study | Koning, M. V. van der Sijp, M. Stolker, R. J. Niggebrugge, A. | Anesth Pain Med | 2020 |
Delirium |
| Evaluation of Pediatric Delirium Awareness and Management in Pediatric Intensive Care Units in Turkey | Konca, C. Anil, A. B. Küllüoglu, E. P. Luleyap, D. Anil, M. Tekin, M. | Journal of Pediatric Intensive Care | 2020 |
Awareness Delirium Management Pediatric Turkey |
| Preventive effect of ramelteon on emergence agitation after general anaesthesia in paediatric patients undergoing tonsillectomy: a randomised, placebo-controlled clinical trial | Komazaki, M. Mihara, T. Nakamura, N. Ka, K. Goto, T. | Sci Rep | 2020 | |
| Delirium in burn patients: developing a mobile application for assessment and diagnosis | Kolaei, N. M. M. Ayatollahi, H. Elyasi, F. | J Burn Care Res | 2020 |
Burn |
| Delirium at the end of life | Knoepfel, S. Bode, L. Gehrke, S. Spiller, T. Fuchs, S. Ernst, J. von Känel, R. Boettger, S. | Palliat Support Care | 2020 |
Delirium at the end of life |
| Protocol for the effectiveness of an anesthesiology control tower system in improving perioperative quality metrics and clinical outcomes: The tectonics randomized, pragmatic trial | King, C. R. Abraham, J. Kannampallil, T. G. Fritz, B. A. Abdallah, A. B. Chen, Y. Henrichs, B. Politi, M. Torres, B. A. Mickle, A. Budelier, T. P. McKinnon, S. Gregory, S. Kheterpal, S. Wildes, T. Avidan, M. S. Tectonics Research, Group | F1000Research | 2020 |
NCT02032030 |
| Sleep disturbance and delirium in patients with acromegaly in the early postoperative period after transsphenoidal pituitary surgery | Kim, S. H. Kim, N. Min, K. T. Kim, E. H. Oh, H. Choi, S. H. | Medicine (Baltimore) | 2020 |
Acromegaly/ surgery |
| Frontal electroencephalogram activity during emergence from general anaesthesia in children with and without emergence delirium | Kim, J. Lee, H. C. Byun, S. H. Lim, H. Lee, M. Choung, Y. Kim, E. | Br J Anaesth | 2020 |
brain waves |
| Safety and efficacy of pharmacologic agents used for rapid tranquilization of emergency department patients with acute agitation or excited delirium | Kim, H. K. Leonard, J. B. Corwell, B. N. Connors, N. J. | 2020 |
acute agitation |
|
| Effect of Timing of Intravenous Fentanyl Administration on the Incidence of Posttonsillectomy Nausea and Vomiting | Kim, H. J. Kim, M. S. Kim, H. Y. Park, W. K. Kim, W. S. Kim, S. Kim, H. J. | Laryngoscope | 2020 |
Postoperative nausea and vomiting |
| Effect on Quality of Care of a Delirium Prevention Campaign for Surgical Intensive Care Nurses | Kim, H. Lee, S. M. | Publish Ahead of Print | 2020 | |
| Ultrasound-Guided Pecto-Intercostal Fascial Block for Postoperative Pain Management in Cardiac Surgery: A Prospective, Randomized, Placebo-Controlled Trial | Khera, T. Murugappan, K. R. Leibowitz, A. Bareli, N. Shankar, P. Gilleland, S. Wilson, K. Oren-Grinberg, A. Novack, V. Venkatachalam, S. Rangasamy, V. Subramaniam, B. | J Cardiothorac Vasc Anesth | 2020 |
3-minute diagnostic Confusion Assessment Method |
| Delirium Incidence, Duration, and Severity in Critically Ill Patients With Coronavirus Disease 2019 | Khan, S. H. Lindroth, H. Perkins, A. J. Jamil, Y. Wang, S. Roberts, S. Farber, M. Rahman, O. Gao, S. Marcantonio, E. R. Boustani, M. Machado, R. Khan, B. A. | Crit Care Explor | 2020 |
brain diseases |
| Delirium, Cerebral Perfusion and High Frequency Vital Sign Monitoring in the Critically Ill: The CONFOCAL-2 Feasibility Study | Khan, J. M. Wood, M. D. Lee, K. F. H. Maslove, D. Muscedere, J. English, S. W. Ball, I. Slessarev, M. Boyd, J. G. | Annals of the American Thoracic Society | 2020 |
NCT03141619 |
| Melatonin for delirium prevention in hospitalized patients: A systematic review and meta-analysis | Khaing, K. Nair, B. R. | J Psychiatr Res | 2020 |
Delirium |
| Delirium in Older Patients With COVID-19 Presenting to the Emergency Department | Kennedy, M. Helfand, B. K. I. Gou, R. Y. Gartaganis, S. L. Webb, M. Moccia, J. M. Bruursema, S. N. Dokic, B. McCulloch, B. Ring, H. Margolin, J. D. Zhang, E. Anderson, R. Babine, R. L. Hshieh, T. Wong, A. H. Taylor, R. A. Davenport, K. Teresi, B. Fong, T. | JAMA Netw Open | 2020 |
Aged |
| Protocol for the Prognosticating Delirium Recovery Outcomes Using Wakefulness and Sleep Electroencephalography (P-DROWS-E) study: A prospective observational study of delirium in elderly cardiac surgical patients | Kendall Smith, S. Nguyen, T. Labonte, A. K. Kafashan, M. Hyche, O. Guay, C. S. Wilson, E. Chan, C. W. Luong, A. Brian Hickman, L. Fritz, B. A. Emmert, D. Graetz, T. J. Melby, S. J. Lucey, B. P. Ju, Y. E. S. Wildes, T. S. Avidan, M. S. Palanca, B. J. A. | BMJ Open | 2020 |
aged |
| Prevalence of Geriatric Syndromes and the Need for Hospice Care in Older Patients of the Emergency Department: A Study in an Asian Medical Center | Ke, Y. T. Peng, A. C. Shu, Y. M. Chung, M. H. Tsai, K. T. Chen, P. J. Weng, T. C. Hsu, C. C. Lin, H. J. Huang, C. C. | Emergency Medicine International | 2020 |
advance care planning |
| The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [11C]PBR28 binding and exploration of its link to post-operative delirium | Katsumi, Y. Racine, A. M. Torrado-Carvajal, A. Loggia, M. L. Hooker, J. M. Greve, D. N. Hightower, B. G. Catana, C. Cavallari, M. Arnold, S. E. Fong, T. G. Vasunilashorn, S. M. Marcantonio, E. R. Schmitt, E. M. Xu, G. Libermann, T. A. Barrett, L. F. Inouy | NeuroImage: Clinical | 2020 |
PET-MRI scanner |
| Association between visitation restriction during the COVID-19 pandemic and delirium incidence among emergency admission patients: a single-center retrospective observational cohort study in Japan | Kandori, K. Okada, Y. Ishii, W. Narumiya, H. Maebayashi, Y. Iizuka, R. | Journal of Intensive Care | 2020 |
adult |
| Intensive Care Unit Nurses’ Beliefs About Delirium Assessment and Management | Kimberly J. Oosterhouse, RN, PhD Catherine Vincent, RN, PhD Marquis D. Foreman, RN, PhD Valerie A. Gruss, PhD, APRN Colleen Corte, RN, PhD Barbara Berger, RN, PhD | AACN Adv Crit Care | 2016 |
beliefs; critical care nurses; delirium; older adult; vignettes |
| Using Concept Unique Identifiers to Filter Electronic Health Records for Delirium Cases | Kimberly J. Oosterhouse, PhD, RN, Cynthia D. Young, MSN, RN, Manushi Desai, MBA, RN, Steven Birch, BS, Ron Price, Jr, BA, Kathleen L. Bobay, PhD, RN, FAAN | CIN: Computers, Informatics, Nursing | 2021 |
Concept unique identifiers, Delirium, |
| Delirium incidence, risk factors, and treatments in older adults receiving chemotherapy: A systematic review and meta-analysis | Jung, P. Puts, M. Frankel, N. Syed, A. T. Alam, Z. Yeung, L. Malik, U. Rosario, C. Ayala, A. P. Hudson, J. Alibhai, S. M. H. | J Geriatr Oncol | 2020 |
Aged |
| Postoperative delirium: perioperative assessment, risk reduction, and management | Jin, Z. Hu, J. Ma, D. | Br J Anaesth | 2020 |
Blood Transfusion |
| Platelet-to-lymphocyte ratio as a predictive index for delirium in critically ill patients: A retrospective observational study | Jiang, X. Shen, Y. Fang, Q. Zhang, W. Cheng, X. | Medicine (Baltimore) | 2020 |
Aged |