What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.
- Authors
- Miller, D. Lewis, S. R. Pritchard, M. W. Schofield-Robinson, O. J. Shelton, C. L. Alderson, P. Smith, A. F.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
BACKGROUND: The use of anaesthetics in the elderly surgical population (more than 60 years of age) is increasing. Postoperative delirium, an acute condition characterized by reduced awareness of the environment and a disturbance in attention, typically occurs between 24 and 72 hours after surgery and can affect up to 60% of elderly surgical patients. Postoperative cognitive dysfunction (POCD) is a new-onset of cognitive impairment which may persist for weeks or months after surgery.Traditionally, surgical anaesthesia has been maintained with inhalational agents. End-tidal concentrations require adjustment to balance the risks of accidental awareness and excessive dosing in elderly people. As an alternative, propofol-based total intravenous anaesthesia (TIVA) offers a more rapid recovery and reduces postoperative nausea and vomiting. Using TIVA with a target controlled infusion (TCI) allows plasma and effect-site concentrations to be calculated using an algorithm based on age, gender, weight and height of the patient.TIVA is a viable alternative to inhalational maintenance agents for surgical anaesthesia in elderly people. However, in terms of postoperative cognitive outcomes, the optimal technique is unknown. OBJECTIVES: To compare maintenance of general anaesthesia for elderly people undergoing non-cardiac surgery using propofol-based TIVA or inhalational anaesthesia on postoperative cognitive function, mortality, risk of hypotension, length of stay in the postanaesthesia care unit (PACU), and hospital stay. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2017, Issue 11), MEDLINE (1946 to November 2017), Embase (1974 to November 2017), PsycINFO (1887 to November 2017). We searched clinical trials registers for ongoing studies, and conducted backward and forward citation searching of relevant articles. SELECTION CRITERIA: We included randomized controlled trials (RCTs) with participants over 60 years of age scheduled for non-cardiac surgery under general anaesthesia. We planned to also include quasi-randomized trials. We compared maintenance of anaesthesia with propofol-based TIVA versus inhalational maintenance of anaesthesia. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed studies for inclusion, extracted data, assessed risk of bias, and synthesized findings. MAIN RESULTS: We included 28 RCTs with 4507 randomized participants undergoing different types of surgery (predominantly cardiovascular, laparoscopic, abdominal, orthopaedic and ophthalmic procedures). We found no quasi-randomized trials. Four studies are awaiting classification because we had insufficient information to assess eligibility.All studies compared maintenance with propofol-based TIVA versus inhalational maintenance of anaesthesia. Six studies were multi-arm and included additional TIVA groups, additional inhalational maintenance or both. Inhalational maintenance agents included sevoflurane (19 studies), isoflurane (eight studies), and desflurane (three studies), and was not specified in one study (reported as an abstract). Some studies also reported use of epidural analgesia/anaesthesia, fentanyl and remifentanil.We found insufficient reporting of randomization methods in many studies and all studies were at high risk of performance bias because it was not feasible to blind anaesthetists to study groups. Thirteen studies described blinding of outcome assessors. Three studies had a high of risk of attrition bias, and we noted differences in the use of analgesics between groups in six studies, and differences in baseline characteristics in five studies. Few studies reported clinical trials registration, which prevented assessment of risk of selective reporting bias.We found no evidence of a difference in incidences of postoperative delirium according to type of anaesthetic maintenance agents (odds ratio (OR) 0.59, 95% confidence interval (CI) 0.15 to 2.26; 321 participants; five studies; very low-certainty evidence); we noted during sensitivity analysis that using different time points in one study may influence direction of this result. Thirteen studies (3215 participants) reported POCD, and of these, six studies reported data that could not be pooled; we noted no difference in scores of POCD in four of these and in one study, data were at a time point incomparable to other studies. We excluded one large study from meta-analysis because study investigators had used non-standard anaesthetic management and this study was not methodologically comparable to other studies. We combined data for seven studies and found low-certainty evidence that TIVA may reduce POCD (OR 0.52, 95% CI 0.31 to 0.87; 869 participants).We found no evidence of a difference in mortality at 30 days (OR 1.21, 95% CI 0.33 to 4.45; 271 participants; three studies; very low-certainty evidence). Twelve studies reported intraoperative hypotension. We did not perform meta-analysis for 11 studies for this outcome. We noted visual inconsistencies in these data, which may be explained by possible variation in clinical management and medication used to manage hypotension in each study (downgraded to low-certainty evidence); one study reported data in a format that could not be combined and we noted little or no difference between groups in intraoperative hypotension for this study. Eight studies reported length of stay in the PACU, and we did not perform meta-analysis for seven studies. We noted visual inconsistencies in these data, which may be explained by possible differences in definition of time points for this outcome (downgraded to very low-certainty evidence); data were unclearly reported in one study. We found no evidence of a difference in length of hospital stay according to type of anaesthetic maintenance agent (mean difference (MD) 0 days, 95% CI -1.32 to 1.32; 175 participants; four studies; very low-certainty evidence).We used the GRADE approach to downgrade the certainty of the evidence for each outcome. Reasons for downgrading included: study limitations, because some included studies insufficiently reported randomization methods, had high attrition bias, or high risk of selective reporting bias; imprecision, because we found few studies; inconsistency, because we noted heterogeneity across studies. AUTHORS’ CONCLUSIONS: We are uncertain whether maintenance with propofol-based TIVA or with inhalational agents affect incidences of postoperative delirium, mortality, or length of hospital stay because certainty of the evidence was very low. We found low-certainty evidence that maintenance with propofol-based TIVA may reduce POCD. We were unable to perform meta-analysis for intraoperative hypotension or length of stay in the PACU because of heterogeneity between studies. We identified 11 ongoing studies from clinical trials register searches; inclusion of these studies in future review updates may provide more certainty for the review outcomes.
- PMID
- Keywords
Aged
Anesthesia, Inhalation
Anesthesia, Intravenous
Anesthetics, Inhalation
Anesthetics, Intravenous/*adverse effects
Cognition/*drug effects
Cognition Disorders/chemically induced
Delirium/chemically induced
Desflurane
Humans
Hypotension/chemically induced
Isoflurane/adverse effects/analogs & derivatives
Methyl Ethers/adverse effects
Middle Aged
Postoperative Complications/chemically induced/mortality
Propofol/*adverse effects
Randomized Controlled Trials as Topic
Sevoflurane
*Surgical Procedures, Operative
- Page(s)
- Volume
- 8
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Implementation of ABCDEF care bundle in intensive care units: A cross-sectional survey | Liang, S. Chau, J. P. C. Lo, S. H. S. Li, S. Gao, M. | Nurs Crit Care | 2021 |
ABCDEF care bundle |
| Lymphocyte and NK Cell Counts Can Predict Sepsis-Associated Delirium in Elderly Patients | Li, D. Zhang, J. Bai, G. Chen, J. Cheng, W. Cui, N. | Front Aging Neurosci | 2021 |
NK cell |
| Safety and Efficacy of Dexmedetomidine in Acutely Ill Adults Requiring Noninvasive Ventilation: A Systematic Review and Meta-analysis of Randomized Trials | Lewis, K. Piticaru, J. Chaudhuri, D. Basmaji, J. Fan, E. Møller, M. H. Devlin, J. W. Alhazzani, W. | Chest | 2021 |
dexmedetomidine |
| Pharmacological strategies to prevent postoperative delirium: a systematic review and network meta-analysis | Lee, J. M. Cho, Y. J. Ahn, E. J. Choi, G. J. Kang, H. | Anesth Pain Med (Seoul) | 2021 |
Delirium |
| Evaluation of Melatonin Practices for Delirium in Pediatric Critically Ill Patients | Laudone, T. W. Beck, S. D. Lahr, H. J. | J Pediatr Pharmacol Ther | 2021 |
antipsychotic |
| Results from a double blinded, randomised, placebo-controlled, feasibility trial of melatonin for the treatment of delirium in older medical inpatients | Lange, P. W. Clayton-Chubb, D. I. Watson, R. Maier, A. B. | Intern Med J | 2021 |
Aged |
| Delirium, Cerebral Perfusion, and High-Frequency Vital-Sign Monitoring in the Critically Ill. The CONFOCAL-2 Feasibility Study | Khan, J. M. Wood, M. D. Lee, K. F. H. Maslove, D. Muscedere, J. English, S. W. Ball, I. Slessarev, M. Boyd, J. G. | Ann Am Thorac Soc | 2021 |
cerebral oxygenation |
| Preoperative brain MRI features and occurrence of postoperative delirium | Kant, I. M. J. de Bresser, J. van Montfort, S. J. T. Mutsaerts, Hjmm Witkamp, T. D. Buijsrogge, M. Spies, C. Hendrikse, J. Slooter, A. J. C. | J Psychosom Res | 2021 |
Aged |
| Intraoperative monitoring parameters and postoperative delirium: Results of a prospective cross-sectional trial | Jung, C. Hinken, L. Fischer-Kumbruch, M. Trübenbach, D. Fielbrand, R. Schenk, I. Diegmann, O. Krauß, T. Scheinichen, D. Schultz, B. | Medicine (Baltimore) | 2021 |
Adult |
| Development of the AL-O-A Score for Delirium Screening in Acute Internal Medicine: a Monocentric Prospective Study | John, G. Bovet, V. Verdon, V. Zender, H. Donzé, J. | J Gen Intern Med | 2021 |
adult |
| Intravenous Iron in a Prehabilitation Program for Older Surgical Patients: Prospective Cohort Study | Janssen, T. L. Steyerberg, E. W. van Gammeren, A. J. Ho, G. H. Gobardhan, P. D. van der Laan, L. | J Surg Res | 2021 |
Abdomen/surgery |
| Comparative associations between anticholinergic burden and emergency department visits for anticholinergic adverse events in older Korean adults: a nested case-control study using national claims data for validation of a novel country-specific scale | Hwang, S. Chung, J. E. Jun, K. Ah, Y. M. Kim, K. I. Lee, J. Y. | BMC Pharmacol Toxicol | 2021 |
Anticholinergic syndromes |
| Evaluation of QTc Interval Effects of Antipsychotic Medications for Intensive Care Unit Delirium in Pediatric Patients | Hutchins, L. M. Shipman, A. Zimmerman, K. O. Heath, T. S. | J Pediatr Pharmacol Ther | 2021 |
QTc interval prolongation |
| Implementing a Rapid, Two-Step Delirium Screening Protocol in Acute Care: Barriers and Facilitators | Husser, E. K. Fick, D. M. Boltz, M. Shrestha, P. Siuta, J. Malloy, S. Overstreet, A. Leslie, D. L. Ngo, L. Jung, Y. Inouye, S. K. Marcantonio, E. R. | J Am Geriatr Soc | 2021 |
delirium |
| Higher versus lower mean arterial pressure target management in older patients having non-cardiothoracic surgery: A prospective randomized controlled trial | Hu, A. M. Qiu, Y. Zhang, P. Zhao, R. Li, S. T. Zhang, Y. X. Zheng, Z. H. Hu, B. L. Yang, Y. L. Zhang, Z. J. | J Clin Anesth | 2021 |
Elderly patients |
| Personalized Blood Pressure Management During Cardiac Surgery With Cerebral Autoregulation Monitoring: A Randomized Trial | Hogue, C. W. Brown, C. H. th Hori, D. Ono, M. Nomura, Y. Balmert, L. C. Srdanovic, N. Grafman, J. Brady, K. | Semin Thorac Cardiovasc Surg | 2021 |
Blood pressure |
| Clinical Features and Outcomes of Patients with Dementia Compared to an Aging Cohort Hospitalized During the Initial New York City COVID-19 Wave | Harb, A. A. Chen, R. Chase, H. S. Natarajan, K. Noble, J. M. | J Alzheimers Dis | 2021 |
Aged |
| Perioperative Multidisciplinary Delirium Prevention: A Longitudinal Case Report | Hamlet, K. M. Pasternak, E. Rabai, F. Mufti, M. Hernaiz Alonso, C. Price, C. C. | A A Pract | 2021 | |
| Cerebrospinal Fluid Concentration of Neurogranin in Hip Fracture Patients with Delirium | Halaas, N. B. Zetterberg, H. Idland, A. V. Knapskog, A. B. Watne, L. O. Blennow, K. | J Alzheimers Dis | 2021 |
Alzheimer’s disease |
| A retrospective study of factors associated with persistent delirium | Goto, H. Yamauchi, T. Okumura, K. Matsuoka, K. Toritsuka, M. Yasuno, F. Uemura, H. Kuki, K. Makinodan, M. Kishimoto, T. | Psychogeriatrics | 2021 |
Case-Control Studies |
| Association Between Early Tracheostomy and Delirium in Older Adults in the United States | Gazda, A. J. Kwak, M. J. Jani, P. Dinh, K. Hussain, R. Dronavalli, G. Warner, M. Salas De Armas, I. Kumar, S. Nathan, S. Kar, B. Gregoric, I. D. Patel, B. Akkanti, B. | J Cardiothorac Vasc Anesth | 2021 |
delirium |
| Poor outcomes of delirium in the intensive care units are amplified by increasing age: A retrospective cohort study | Gao, W. Zhang, Y. P. Jin, J. F. | World J Emerg Med | 2021 |
Aging |
| Postoperative Delirium is Associated With Prolonged Head and Neck Resection and Reconstruction Surgery: An Institutional Study | Edwards, D. A. Medhavy, A. Hoffman, O. G. Hoffman, G. R. | J Oral Maxillofac Surg | 2021 |
Aged |
| Delirium Assessment in Critically Ill Older Adults: Considerations During the COVID-19 Pandemic | Duggan, M. C. Van, J. Ely, E. W. | Crit Care Clin | 2021 |
Aged |
| Delirium occurrence in older Irish adults admitted to an acute medical hospital: a prospective cohort study | Dolan, C. Mohd Zubir, M. Melvin, V. McCarthy, G. Meagher, D. Adamis, D. | Ir J Psychol Med | 2021 |
Delirium |
| Clinical utility of brain computed tomography in prediction of post-stroke delirium | Czyzycki, M. Glen, A. Slowik, A. Chrzan, R. Dziedzic, T. | J Neural Transm (Vienna) | 2021 |
Brain atrophy |
| Risk factors for long-term cognitive impairment in ICU survivors: A multicenter, prospective cohort study | Collet, M. O. Egerod, I. Thomsen, T. Wetterslev, J. Lange, T. Ebdrup, B. H. Perner, A. | Acta Anaesthesiol Scand | 2021 | |
| Integration of family caregivers in delirium prevention care for hospitalized older adults: A case study analysis | Cohen, C. Pereira, F. Kampel, T. Bélanger, L. | J Adv Nurs | 2021 |
Aged |
| Investigating how electroencephalogram measures associate with delirium: A systematic review | Boord, M. S. Moezzi, B. Davis, D. Ross, T. J. Coussens, S. Psaltis, P. J. Bourke, A. Keage, H. A. D. | Clin Neurophysiol | 2021 |
Delirium |
| Pharmacologic Management of Intensive Care Unit Delirium: Clinical Prescribing Practices and Outcomes in More Than 8500 Patient Encounters | Boncyk, C. S. Farrin, E. Stollings, J. L. Rumbaugh, K. Wilson, J. E. Marshall, M. Feng, X. Shotwell, M. S. Pandharipande, P. P. Hughes, C. G. | Anesth Analg | 2021 | |
| Predictors of delirium in older patients at the emergency department: a prospective multicentre derivation study | Béland, E. Nadeau, A. Carmichael, P. H. Boucher, V. Voyer, P. Pelletier, M. Gouin, É Daoust, R. Berthelot, S. Lamontagne, M. E. Morin, M. Lemire, S. Vu, T. T. M. Émond, M. | CJEM | 2021 |
Delirium |
| Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort | Atkins, J. L. Pilling, L. C. Heales, C. J. Savage, S. Kuo, C. L. Kuchel, G. A. Steffens, D. C. Melzer, D. | J Alzheimers Dis | 2021 |
Cohort |
| Awareness of Delirium by ICU Nurses | Asmar, I. T. Yaseen, K. S. Jaghama, M. K. Khawaja, Y. F. Alwredat, A. A. Sadaqa, M. H. | Crit Care Nurs Q | 2021 | |
| Psychiatric Clinical Profiles and Pharmacological Interactions in COVID-19 Inpatients Referred to a Consultation Liaison Psychiatry Unit: a Cross-Sectional Study | Arbelo, N. López-Pelayo, H. Sagué, M. Madero, S. Pinzón-Espinosa, J. Gomes-da-Costa, S. Ilzarbe, L. Anmella, G. Llach, C. D. Imaz, M. L. Cámara, M. M. Pintor, L. | Psychiatr Q | 2021 |
Covid-19 |
| Octogenarian patients' sleep and delirium experiences in hospital and four years after aortic valve replacement: a qualitative interview study | Amofah, H. A. Broström, A. Instenes, I. Fridlund, B. Haaverstad, R. Kuiper, K. Ranhoff, A. H. Norekvål, T. M. | BMJ Open | 2021 |
Aged, 80 and over |
| Delirium and quality of life in critically ill patients: a prospective cohort study | Luz, L. F. D. S. Santos, M. C. D. Ramos, T. A. Almeida, C. B. Rover, M. C. Dal'Pizzol, C. P. Pohren, C. L. D. S. Martins, A. V. D. S. Boniatti, M. M. | Rev Bras Ter Intensiva | 2020 |
adult |
| Bispectral Index Monitoring With Density Spectral Array for Delirium Detection | Luo, A. Muraida, S. Pinchotti, D. Richardson, E. Ye, E. Hollingsworth, B. Win, A. Myers, O. Langsjoen, J. Valles, E. Zolyomi, A. Quinn, D. K. | Psychosomatics | 2020 |
bispectral index monitoring |
| Delirium prediction in the intensive care unit: a temporal approach | Lucini, F. R. Fiest, K. M. Stelfox, H. T. Lee, J. | Annu Int Conf IEEE Eng Med Biol Soc | 2020 |
Alberta |
| Impact of place of residence, frailty and other factors on rehabilitation outcomes post hip fracture | Low, S. Wee, E. Dorevitch, M. | Age Ageing | 2020 |
clinical frailty scale |
| Ramelteon for Decreasing Delirium in Surgical Intensive Care Unit Patients | Lopez, C. N. Fuentes, A. Dhala, A. Balk, J. | Clinical Medicine Insights: Psychiatry | 2020 |
haloperidol |
| Different depths of sedation versus risk of delirium in adult mechanically ventilated patients: A systematic review and meta-analysis | Long, L. Ren, S. Gong, Y. Zhao, H. He, C. Shen, L. Zhao, H. Ma, P. | PLoS One | 2020 |
Adult |
| Association of Troponin Levels With Mortality in Italian Patients Hospitalized With Coronavirus Disease 2019: Results of a Multicenter Study | Lombardi, C. M. Carubelli, V. Iorio, A. Inciardi, R. M. Bellasi, A. Canale, C. Camporotondo, R. Catagnano, F. Dalla Vecchia, L. A. Giovinazzo, S. Maccagni, G. Mapelli, M. Margonato, D. Monzo, L. Nuzzi, V. Oriecuia, C. Peveri, G. Pozzi, A. Provenzale, G. S | JAMA Cardiol | 2020 |
Aged |
| Role of dexmedetomidine in the treatment of delirium in critically ill patients: a systematic review and meta-analysis | Liu, X. Xiong, J. Tang, Y. Gong, C. C. Wang, D. F. | Minerva anestesiologica | 2020 |
adult |
| Delirium Severity Trajectories and Outcomes in ICU Patients. Defining a Dynamic Symptom Phenotype | Lindroth, H. Khan, B. A. Carpenter, J. S. Gao, S. Perkins, A. J. Khan, S. H. Wang, S. Jones, R. N. Boustani, M. A. | Ann Am Thorac Soc | 2020 |
critical care |
| Risk factors for postoperative delirium in patients with triple-branched stent graft implantation | Lin, Y. Chen, Q. Zhang, H. Chen, L. W. Peng, Y. Huang, X. Chen, Y. Li, S. Lin, L. | J Cardiothorac Surg | 2020 |
Apache |
| Cerebrospinal fluid cholinergic biomarkers are associated with postoperative delirium in elderly patients undergoing Total hip/knee replacement: a prospective cohort study | Lin, X. Tang, J. Liu, C. Li, X. Cao, X. Wang, B. Dong, R. Xu, W. Yu, X. Wang, M. Bi, Y. | BMC Anesthesiol | 2020 |
Cerebrospinal fluid |
| Effect of Dexmedetomidine on Delirium in Elderly Surgical Patients: A Meta-analysis of Randomized Controlled Trials | Lin, C. Tu, H. Jie, Z. Zhou, X. Li, C. | Ann Pharmacother | 2020 |
delirium |
| The relationship between intraoperative cerebral oximetry and postoperative delirium in patients undergoing off-pump coronary artery bypass graft surgery: a retrospective study | Lim, L. Nam, K. Lee, S. Cho, Y. J. Yeom, C. W. Jung, S. Moon, J. Y. Jeon, Y. | BMC Anesthesiol | 2020 |
Cerebral oximetry |
| Effects of nonpharmacological delirium-prevention interventions on critically ill patients' clinical, psychological, and family outcomes: A systematic review and meta-analysis | Liang, S. Chau, J. P. C. Lo, S. H. S. Zhao, J. Choi, K. C. | Aust Crit Care | 2020 |
Delirium |
| Validation of PREdiction of DELIRium in ICu patients (PRE-DELIRIC) among patients in intensive care units: A retrospective cohort study | Liang, S. Chau, J. P. C. Lo, S. H. S. Bai, L. Yao, L. Choi, K. C. | Nurs Crit Care | 2020 |
Icu |
| Prognostic Impact of Delirium in Older People With/Without Dementia: A Retrospective Cohort Study in Taiwan | Liang, C. K. Chuang, H. Y. Hsiao, F. Y. Chou, M. Y. Liu, T. Y. Yang, C. C. Chen, L. K. | Journal of Nutrition, Health and Aging | 2020 |
aged |
| Effects of modified version of the Hospital Elder Life Program on post-discharge cognitive function and activities of daily living among older adults undergoing total knee arthroplasty | Liang, C. K. Chu, C. S. Hsu, Y. H. Chou, M. Y. Wang, Y. C. Lin, Y. T. Renn, J. H. Liu, T. Y. Yang, C. C. | Arch Gerontol Geriatr | 2020 |
Cognitive decline |
| Incidence and Risk Factors for Delirium in Older Patients Following Intensive Care Unit Admission: A Prospective Observational Study | Li, X. Zhang, L. Gong, F. Ai, Y. | The journal of nursing research : JNR | 2020 |
aged |
| Surviving and Thriving 1 Year After Cardiac Surgery: Frailty and Delirium Matter | Li, H. C. Wei, Y. C. Hsu, R. B. Chi, N. H. Wang, S. S. Chen, Y. S. Chen, S. Y. Chen, C. C. H. Inouye, S. K. | Annals of Thoracic Surgery | 2020 |
ADL disability |
| Pharmacist Identification of Medication Therapy Problems Involving Cognition Among Older Adults Followed by a Home-Based Care Team | Levine, A. M. P. Emonds, E. E. Smith, M. A. Rickles, N. M. Kuchel, G. A. Steffens, D. C. Ohlheiser, A. Fortinsky, R. H. | Drugs and Aging | 2020 |
aged |
| Multicomponent Interventions for the Prevention of Delirium in Hospitalized Older People: A Meta-Analysis | León-Salas, B. Trujillo-Martín, M. M. Martínez Del Castillo, L. P. García-García, J. Pérez-Ros, P. Rivas-Ruiz, F. Serrano-Aguilar, P. | J Am Geriatr Soc | 2020 |
delirium |
| Pharmacologic interventions for prevention of delirium in hospitalized older people: A meta-analysis | León-Salas, B. Trujillo-Martín, M. M. Del Castillo, L. P. M. García, J. G. Pérez-Ros, P. Ruiz, F. R. Serrano-Aguilar, P. | Arch Gerontol Geriatr | 2020 |
Aged |
| "You've got to keep moving, keep going": Understanding older patients' experiences and perceptions of delirium and nonpharmacological delirium prevention strategies in the acute hospital setting | Lee-Steere, K. Liddle, J. Mudge, A. Bennett, S. McRae, P. Barrimore, S. E. | J Clin Nurs | 2020 |
Aged |
| The Effect of Intraoperative Magnesium Sulphate Infusion on Emergence Agitation after Ambulatory Ophthalmic Surgery in Children | Lee, Y. J. Kim, B. Y. Park, J. H. Kim, S. Y. Park, H. Y. Do, S. H. | J Clin Med | 2020 |
ambulatory surgery |
| Effects of the ABCDE bundle on the prevention of post-intensive care syndrome: A retrospective study | Lee, Y. Kim, K. Lim, C. Kim, J. S. | Journal of advanced nursing | 2020 |
adult |
| Effect of Antipsychotics and Non-Pharmacotherapy for the Management of Delirium in People Receiving Palliative Care | Lee, K. Y. Tan, E. C. K. Hanrahan, J. R. Chircop, C. Michael, F. Ong, J. A. | J Pain Palliat Care Pharmacother | 2020 |
Delirium |
| Effect of magnesium supplementation on emergence delirium and postoperative pain in children undergoing strabismus surgery: a prospective randomised controlled study | Lee, J. H. Choi, S. Lee, M. Jang, Y. E. Kim, E. H. Kim, J. T. Kim, H. S. | BMC Anesthesiol | 2020 |
Emergence delirium |
| Neurologic Complications in Patients With Cancer | Lee, E. Q. | Continuum (Minneapolis, Minn.) | 2020 |
adult |
| Melatonin to prevent delirium in patients with advanced cancer: a double blind, parallel, randomized, controlled, feasibility trial | Lawlor, P. G. McNamara-Kilian, M. T. MacDonald, A. R. Momoli, F. Tierney, S. Lacaze-Masmonteil, N. Dasgupta, M. Agar, M. Pereira, J. L. Currow, D. C. Bush, S. H. | BMC Palliat Care | 2020 |
Advanced cancer |
| Cognitive function and health-related quality of life 1 year after acute brain injury: An observational study | Larsen, L. K. Møller, K. Petersen, M. Egerod, I. | Acta Anaesthesiol Scand | 2020 |
Acute brain injury |
| The One-Two Punch of Delirium and Dementia During the COVID-19 Pandemic and Beyond | LaHue, S. C. Douglas, V. C. Miller, B. L. | Front Neurol | 2020 |
Alzheimer’s disease and related dementias (ADRD) |
| Postoperative Delirium is a Risk Factor of Poor Evolution Three Years After Cardiac Surgery: An Observational Cohort Study | Labaste, F. Porterie, J. Bousquet, P. Marcheix, B. Sanchez-Verlaan, P. Frances, B. Valet, P. Dray, C. Minville, V. | Clin Interv Aging | 2020 |
cardiac surgery |
| Delirium among Hospitalized Older Adults with Acute Heart Failure Exacerbation | Kwak, M. J. Avritscher, E. Holmes, H. M. Jantea, R. Flores, R. Rianon, N. Chung, T. H. Balan, P. Dhoble, A. | J Card Fail | 2020 |
Acute Heart Failure |
| Association between polypharmacy and the persistence of delirium: a retrospective cohort study | Kurisu, K. Miyabe, D. Furukawa, Y. Shibayama, O. Yoshiuchi, K. | Biopsychosoc Med | 2020 |
Classification and regression tree |
| Elevated Procalcitonin as a Risk Factor for Postoperative Delirium in the Elderly after Cardiac Surgery-A Prospective Observational Study | Kupiec, A. Adamik, B. Kozera, N. Gozdzik, W. | J Clin Med | 2020 |
cardiac surgery |
| The CAM-ICU-7 and ICDSC as measures of delirium severity in critically ill adult patients | Krewulak, K. D. Rosgen, B. K. Ely, E. W. Stelfox, H. T. Fiest, K. M. | PLoS One | 2020 |
Adult |
| Adaptation and Validation of a Chart-Based Delirium Detection Tool for the ICU (CHART-DEL-ICU) | Krewulak, K. D. Hiploylee, C. Ely, E. W. Stelfox, H. T. Inouye, S. K. Fiest, K. M. | J Am Geriatr Soc | 2020 |
Confusion Assessment Method for Intensive Care Unit (CAM-ICU) |
| Effectiveness of an intensive care unit family education intervention on delirium knowledge: a pre-test post-test quasi-experimental study | Krewulak, K. D. Bull, M. J. Wesley Ely, E. Davidson, J. E. Stelfox, H. T. Fiest, K. M. | Can J Anaesth | 2020 |
Critical care |
| Assessment and Management of Delirium in Critically Ill Veterans | Kresevic, D. M. Miller, D. Fuseck, C. W. Wade, M. Whitney, L. Conley, M. Rimac, J. Jacono, F. O'Leary-Wilson, H. L. Burant, C. J. | Critical care nurse | 2020 |
article |
| Delirium Post-Stroke: Short- and Long-Term Effect on Depression, Anxiety, Apathy and Aggression (Research Study-Part of PROPOLIS Study) | Kowalska, K. Droś, J. Mazurek, M. Pasińska, P. Gorzkowska, A. Klimkowicz-Mrowiec, A. | J Clin Med | 2020 |
aggression |
| Intrathecal Morphine Is Associated with Less Delirium Following Hip Fracture Surgery: A Register Study | Koning, M. V. van der Sijp, M. Stolker, R. J. Niggebrugge, A. | Anesth Pain Med | 2020 |
Delirium |
| Evaluation of Pediatric Delirium Awareness and Management in Pediatric Intensive Care Units in Turkey | Konca, C. Anil, A. B. Küllüoglu, E. P. Luleyap, D. Anil, M. Tekin, M. | Journal of Pediatric Intensive Care | 2020 |
Awareness Delirium Management Pediatric Turkey |
| Preventive effect of ramelteon on emergence agitation after general anaesthesia in paediatric patients undergoing tonsillectomy: a randomised, placebo-controlled clinical trial | Komazaki, M. Mihara, T. Nakamura, N. Ka, K. Goto, T. | Sci Rep | 2020 | |
| Delirium in burn patients: developing a mobile application for assessment and diagnosis | Kolaei, N. M. M. Ayatollahi, H. Elyasi, F. | J Burn Care Res | 2020 |
Burn |
| Delirium at the end of life | Knoepfel, S. Bode, L. Gehrke, S. Spiller, T. Fuchs, S. Ernst, J. von Känel, R. Boettger, S. | Palliat Support Care | 2020 |
Delirium at the end of life |
| Protocol for the effectiveness of an anesthesiology control tower system in improving perioperative quality metrics and clinical outcomes: The tectonics randomized, pragmatic trial | King, C. R. Abraham, J. Kannampallil, T. G. Fritz, B. A. Abdallah, A. B. Chen, Y. Henrichs, B. Politi, M. Torres, B. A. Mickle, A. Budelier, T. P. McKinnon, S. Gregory, S. Kheterpal, S. Wildes, T. Avidan, M. S. Tectonics Research, Group | F1000Research | 2020 |
NCT02032030 |
| Sleep disturbance and delirium in patients with acromegaly in the early postoperative period after transsphenoidal pituitary surgery | Kim, S. H. Kim, N. Min, K. T. Kim, E. H. Oh, H. Choi, S. H. | Medicine (Baltimore) | 2020 |
Acromegaly/ surgery |
| Frontal electroencephalogram activity during emergence from general anaesthesia in children with and without emergence delirium | Kim, J. Lee, H. C. Byun, S. H. Lim, H. Lee, M. Choung, Y. Kim, E. | Br J Anaesth | 2020 |
brain waves |
| Safety and efficacy of pharmacologic agents used for rapid tranquilization of emergency department patients with acute agitation or excited delirium | Kim, H. K. Leonard, J. B. Corwell, B. N. Connors, N. J. | 2020 |
acute agitation |
|
| Effect of Timing of Intravenous Fentanyl Administration on the Incidence of Posttonsillectomy Nausea and Vomiting | Kim, H. J. Kim, M. S. Kim, H. Y. Park, W. K. Kim, W. S. Kim, S. Kim, H. J. | Laryngoscope | 2020 |
Postoperative nausea and vomiting |
| Effect on Quality of Care of a Delirium Prevention Campaign for Surgical Intensive Care Nurses | Kim, H. Lee, S. M. | Publish Ahead of Print | 2020 | |
| Ultrasound-Guided Pecto-Intercostal Fascial Block for Postoperative Pain Management in Cardiac Surgery: A Prospective, Randomized, Placebo-Controlled Trial | Khera, T. Murugappan, K. R. Leibowitz, A. Bareli, N. Shankar, P. Gilleland, S. Wilson, K. Oren-Grinberg, A. Novack, V. Venkatachalam, S. Rangasamy, V. Subramaniam, B. | J Cardiothorac Vasc Anesth | 2020 |
3-minute diagnostic Confusion Assessment Method |
| Delirium Incidence, Duration, and Severity in Critically Ill Patients With Coronavirus Disease 2019 | Khan, S. H. Lindroth, H. Perkins, A. J. Jamil, Y. Wang, S. Roberts, S. Farber, M. Rahman, O. Gao, S. Marcantonio, E. R. Boustani, M. Machado, R. Khan, B. A. | Crit Care Explor | 2020 |
brain diseases |
| Delirium, Cerebral Perfusion and High Frequency Vital Sign Monitoring in the Critically Ill: The CONFOCAL-2 Feasibility Study | Khan, J. M. Wood, M. D. Lee, K. F. H. Maslove, D. Muscedere, J. English, S. W. Ball, I. Slessarev, M. Boyd, J. G. | Annals of the American Thoracic Society | 2020 |
NCT03141619 |
| Melatonin for delirium prevention in hospitalized patients: A systematic review and meta-analysis | Khaing, K. Nair, B. R. | J Psychiatr Res | 2020 |
Delirium |
| Delirium in Older Patients With COVID-19 Presenting to the Emergency Department | Kennedy, M. Helfand, B. K. I. Gou, R. Y. Gartaganis, S. L. Webb, M. Moccia, J. M. Bruursema, S. N. Dokic, B. McCulloch, B. Ring, H. Margolin, J. D. Zhang, E. Anderson, R. Babine, R. L. Hshieh, T. Wong, A. H. Taylor, R. A. Davenport, K. Teresi, B. Fong, T. | JAMA Netw Open | 2020 |
Aged |
| Protocol for the Prognosticating Delirium Recovery Outcomes Using Wakefulness and Sleep Electroencephalography (P-DROWS-E) study: A prospective observational study of delirium in elderly cardiac surgical patients | Kendall Smith, S. Nguyen, T. Labonte, A. K. Kafashan, M. Hyche, O. Guay, C. S. Wilson, E. Chan, C. W. Luong, A. Brian Hickman, L. Fritz, B. A. Emmert, D. Graetz, T. J. Melby, S. J. Lucey, B. P. Ju, Y. E. S. Wildes, T. S. Avidan, M. S. Palanca, B. J. A. | BMJ Open | 2020 |
aged |
| Prevalence of Geriatric Syndromes and the Need for Hospice Care in Older Patients of the Emergency Department: A Study in an Asian Medical Center | Ke, Y. T. Peng, A. C. Shu, Y. M. Chung, M. H. Tsai, K. T. Chen, P. J. Weng, T. C. Hsu, C. C. Lin, H. J. Huang, C. C. | Emergency Medicine International | 2020 |
advance care planning |
| The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [11C]PBR28 binding and exploration of its link to post-operative delirium | Katsumi, Y. Racine, A. M. Torrado-Carvajal, A. Loggia, M. L. Hooker, J. M. Greve, D. N. Hightower, B. G. Catana, C. Cavallari, M. Arnold, S. E. Fong, T. G. Vasunilashorn, S. M. Marcantonio, E. R. Schmitt, E. M. Xu, G. Libermann, T. A. Barrett, L. F. Inouy | NeuroImage: Clinical | 2020 |
PET-MRI scanner |
| Association between visitation restriction during the COVID-19 pandemic and delirium incidence among emergency admission patients: a single-center retrospective observational cohort study in Japan | Kandori, K. Okada, Y. Ishii, W. Narumiya, H. Maebayashi, Y. Iizuka, R. | Journal of Intensive Care | 2020 |
adult |
| Intensive Care Unit Nurses’ Beliefs About Delirium Assessment and Management | Kimberly J. Oosterhouse, RN, PhD Catherine Vincent, RN, PhD Marquis D. Foreman, RN, PhD Valerie A. Gruss, PhD, APRN Colleen Corte, RN, PhD Barbara Berger, RN, PhD | AACN Adv Crit Care | 2016 |
beliefs; critical care nurses; delirium; older adult; vignettes |
| Using Concept Unique Identifiers to Filter Electronic Health Records for Delirium Cases | Kimberly J. Oosterhouse, PhD, RN, Cynthia D. Young, MSN, RN, Manushi Desai, MBA, RN, Steven Birch, BS, Ron Price, Jr, BA, Kathleen L. Bobay, PhD, RN, FAAN | CIN: Computers, Informatics, Nursing | 2021 |
Concept unique identifiers, Delirium, |
| Delirium incidence, risk factors, and treatments in older adults receiving chemotherapy: A systematic review and meta-analysis | Jung, P. Puts, M. Frankel, N. Syed, A. T. Alam, Z. Yeung, L. Malik, U. Rosario, C. Ayala, A. P. Hudson, J. Alibhai, S. M. H. | J Geriatr Oncol | 2020 |
Aged |
| Postoperative delirium: perioperative assessment, risk reduction, and management | Jin, Z. Hu, J. Ma, D. | Br J Anaesth | 2020 |
Blood Transfusion |
| Platelet-to-lymphocyte ratio as a predictive index for delirium in critically ill patients: A retrospective observational study | Jiang, X. Shen, Y. Fang, Q. Zhang, W. Cheng, X. | Medicine (Baltimore) | 2020 |
Aged |