Delirium Bibliography

Delirium Bibliography books graphicWhat is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title
Predictors of Delirium Development in Older Medical Inpatients: Readily Identifiable Factors at Admission.
Authors
O’Regan, Niamh A. Fitzgerald, James Adamis, Dimitrios Molloy, David William Meagher, David Timmons, Suzanne Montero-Odasso, Manuel
Year
2018
Journal
Journal of Alzheimer's Disease
Abstract

Background: Identifying patients at high risk of delirium is crucial to facilitate prevention. Although dementia is the most consistent risk factor across populations, it remains under-diagnosed. Hence understanding other markers of delirium vulnerability on admission is important.Objective: We aimed to identify predictors of incident delirium development in older medical inpatients that were readily identifiable at presentation to the emergency department.Methods: Medical inpatients of ≥70 years were assessed on admission for delirium using the Revised Delirium Rating Scale (DRS-R98) and those with prevalent delirium were excluded. Consenting non-delirious patients were then assessed daily using the DRS-R98. Data pertaining to multiple baseline delirium risk factors were collected, including pre-morbid dementia. Multivariable logistic regression was used to examine which factors predicted the development of incident delirium.Results: Of 555 patients approached, 184 (33.1%) had prevalent delirium. Following other exclusions, 191 were included in the study and 61 developed incident delirium. Predictors of incident delirium on multivariable analysis, controlling for confounders, were dementia (OR 2.54, 95% CI 1.01-6.43, p = 0.048); Barthel Index score (OR 1.15 for each unit decrease in score, 95% CI 1.06-1.25, p = 0.001), and Modified Cumulative Illness Rating Scale score (OR 1.13 for each unit increase in score, 95% CI 1.05-1.22, p = 0.001).Conclusion: Dementia is a well-known risk factor for delirium; however, it too is under-recognized and on admission can be missed. Conversely, the Barthel Index is a simple and widely used measure of functional ability that may prove useful in stratifying those at risk of in-hospital delirium on admission.

PMID

29966197

Keywords
Page(s)
775-785
Issue
3

Search:
Total Records Found: 6289, showing 100 per page
TitleAuthorsJournalYearKeywords
The Association Between Frailty and Delirium Among Hospitalized Patients: An Updated Meta-Analysis Zhang, X. M. Jiao, J. Xie, X. H. Wu, X. J. J Am Med Dir Assoc 2021

Frailty
delirium
hospitalized patients
meta-analysis
mortality

Effectiveness of Bundle Interventions on ICU Delirium: A Meta-Analysis Zhang, S. Han, Y. Xiao, Q. Li, H. Wu, Y. Crit Care Med 2021
Development and validation of a predictive score for ICU delirium in critically ill patients Zhang, H. Yuan, J. Chen, Q. Cao, Y. Wang, Z. Lu, W. Bao, J. BMC Anesthesiol 2021

Delirium
Incidence
Intensive care unit
Prediction
Risk factors

Comparison of the '4-item assessment test' and 'nursing delirium screening scale' delirium screening tools on nonintensive care unit wards: A prospective mixed-method approach Zastrow, I. Tohsche, P. Loewen, T. Vogt, B. Feige, M. Behnke, M. Wolff, A. Kiefmann, R. Olotu, C. Eur J Anaesthesiol 2021
Effects of general versus regional anaesthesia on circadian melatonin rhythm and its association with postoperative delirium in elderly patients undergoing hip fracture surgery: study protocol for a prospective cohort clinical trial Yuan, Y. Song, Y. Wang, G. Jia, Y. Zhou, Y. Mi, X. Jia, X. Wang, X. Liu, C. Li, Y. Shi, C. Han, Y. Guo, X. Zhang, W. Li, Z. BMJ Open 2021

Aged
Anesthesia, Conduction
Circadian Rhythm
Delirium/epidemiology/etiology/prevention & control
Hip Fractures/surgery
Humans
Melatonin
Postoperative Complications
Prospective Studies
adult anaesthesia
anaesthesia in orthopaedics
delirium & cognitive disorders

Association Between Dexamethasone and Delirium in Critically Ill Patients: A Retrospective Cohort Study of a Large Clinical Database Wu, Z. Li, H. Liao, K. Wang, Y. J Surg Res 2021

Delirium
Dexamethasone
Intensive care unit (ICU)
Mortality
Propensity score matching (PSM)

Perioperative risk factors for recovery room delirium after elective non-cardiovascular surgery under general anaesthesia Wu, J. Gao, S. Zhang, S. Yu, Y. Liu, S. Zhang, Z. Mei, W. Perioper Med (Lond) 2021

Delirium
General anaesthesia
Non-cardiac surgery
Postoperative recovery
Risk factors

Management of delirium within intraoperative settings for older adults with hip fracture: a scoping review White, L. B. Coyne, E. Grealish, L. J Clin Nurs 2021

Anaesthesia
delirium
hip fracture
intraoperative

Delirium screening tools validated in the context of palliative care: A systematic review Watt, C. L. Scott, M. Webber, C. Sikora, L. Bush, S. H. Kabir, M. Boland, J. W. Woodhouse, R. Sands, M. B. Lawlor, P. G. Palliat Med 2021

Adult
Delirium/diagnosis
Hospice and Palliative Care Nursing
Humans
Mass Screening
Palliative Care
Delirium
cognitive assessment screening instrument
screening
systematic review

The Relationship of Postoperative Delirium and Unplanned Perioperative Hypothermia in Surgical Patients Wagner, D. Hooper, V. Bankieris, K. Johnson, A. J Perianesth Nurs 2021

noncardiac surgery
postoperative delirium
unplanned hypothermia

Proteome-Wide Analysis using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery Vasunilashorn, S. M. Dillon, S. T. Chan, N. Y. Fong, T. G. Joseph, M. Tripp, B. Xie, Z. Ngo, L. H. Lee, C. G. Elias, J. A. Otu, H. H. Inouye, S. Marcantonio, E. R. Libermann, T. A. J Gerontol A Biol Sci Med Sci 2021

inflammation
postoperative
proteomics

Delirium in your house: a survey during General Practitioner-programmed home visits Tremolizzo, L. Bargossi, L. Storti, B. Ferrarese, C. Bellelli, G. Appollonio, I. Aging Clin Exp Res 2021

4at
Delirium
Dementia
General practitioner
Home visits

Dexmedetomidine for hyperactive delirium at the end of life: An open-label single arm pilot study with dose escalation in adult patients admitted to an inpatient palliative care unit Thomas, B. Lo, W. A. Nangati, Z. Barclay, G. Palliat Med 2021

Adult
Death
Delirium/drug therapy
Dexmedetomidine/therapeutic use
Humans
Hypnotics and Sedatives/therapeutic use
Inpatients
Intensive Care Units
Palliative Care
Pilot Projects
Prospective Studies
Delirium
conscious sedation
dexmedetomidine
hypnotics and sedatives
terminal care

Significant decrease in delirium referrals after changing hypnotic from benzodiazepine to suvorexant Tachibana, M. Inada, T. Ichida, M. Kojima, S. Arai, T. Naito, K. Ozaki, N. Psychogeriatrics 2021

Aged
Azepines
Benzodiazepines/therapeutic use
Delirium/chemically induced/drug therapy
Humans
Hypnotics and Sedatives/adverse effects
Referral and Consultation
Sleep Initiation and Maintenance Disorders/drug therapy
Triazoles
benzodiazepine
delirium
general hospital
hypnotic
psychiatry
suvorexant

Haloperidol, clonidine and resolution of delirium in critically ill patients: a prospective cohort study Smit, L. Dijkstra-Kersten, S. M. A. Zaal, I. J. van der Jagt, M. Slooter, A. J. C. Intensive Care Med 2021

Clonidine/therapeutic use
Cohort Studies
Critical Illness
Delirium/drug therapy
Haloperidol/therapeutic use
Humans
Intensive Care Units
Prospective Studies
Clonidine
Critical care
Delirium
Haloperidol
Intensive care unit

Acute-onset delirium in intensive care COVID patients: association of imperfect brain repair with foodborne micro-pollutants Schneider, F. Agin, A. Baldacini, M. Maurer, L. Schenck, M. Alemann, M. Solis, M. Helms, J. Villette, C. Artzner, T. Kremer, S. Heintz, D. Eur J Neurol 2021

Covid
brain
delirium
erythropoietin
hypoxia
metabolomics

Delirium in acute stroke: A prospective, cross-sectional, cohort study Rollo, E. Callea, A. Brunetti, V. Vollono, C. Marotta, J. Imperatori, C. Frisullo, G. Broccolini, A. Della Marca, G. Eur J Neurol 2021

Cam-icu
delirium
physical restraint
risk factors
stroke
stroke unit

Preoperative Cognitive Impairment and the Prevalence of Postoperative Delirium in Elderly Cancer Patients-A Prospective Observational Study Ristescu, A. I. Pintilie, G. Moscalu, M. Rusu, D. Grigoras, I. Diagnostics (Basel) 2021

Mini-Cog test
Nu-DESC score
elderly patients
postoperative delirium
preoperative cognitive impairment

Delirium in Patients with SARS-CoV-2 Infection: A Multicenter Study Rebora, P. Rozzini, R. Bianchetti, A. Blangiardo, P. Marchegiani, A. Piazzoli, A. Mazzeo, F. Cesaroni, G. Chizzoli, A. Guerini, F. Bonfanti, P. Morandi, A. Faraci, B. Gentile, S. Bna, C. Savelli, G. Citerio, G. Valsecchi, M. G. Mazzola, P. Bellelli, G. J Am Geriatr Soc 2021

Aged
Aged, 80 and over
COVID-19/ mortality
Cohort Studies
Comorbidity
Delirium/ diagnosis/ mortality
Female
Geriatric Assessment
Hospital Mortality
Humans
Inpatients/ statistics & numerical data
Intensive Care Units
Italy/epidemiology
Male
Prevalence
Risk Factors
Covid-19
delirium
hospital
mortality
older adults

Machine Learning to Develop and Internally Validate a Predictive Model for Post-operative Delirium in a Prospective, Observational Clinical Cohort Study of Older Surgical Patients Racine, A. M. Tommet, D. D'Aquila, M. L. Fong, T. G. Gou, Y. Tabloski, P. A. Metzger, E. D. Hshieh, T. T. Schmitt, E. M. Vasunilashorn, S. M. Kunze, L. Vlassakov, K. Abdeen, A. Lange, J. Earp, B. Dickerson, B. C. Marcantonio, E. R. Steingrimsson, J. Travi J Gen Intern Med 2021

Aged
Cohort Studies
Delirium/diagnosis/epidemiology
Humans
Logistic Models
Machine Learning
Prospective Studies
delirium
model prediction
post-operative
statistical learning

Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older UK Biobank Participants Pilling, L. C. Jones, L. C. Masoli, J. A. H. Delgado, J. Atkins, J. L. Bowden, J. Fortinsky, R. H. Kuchel, G. A. Melzer, D. J Am Geriatr Soc 2021

biomarker
delirium
genetic
risk factor
vitamin D

Delirium in older adults is associated with development of new dementia: a systematic review and meta-analysis Pereira, J. V. Aung Thein, M. Z. Nitchingham, A. Caplan, G. A. Int J Geriatr Psychiatry 2021

delirium
dementia
meta-analysis
older adults
systematic review

Mortality and Medical Complications of Subtrochanteric Fracture Fixation Panteli, M. Giannoudi, M. P. Lodge, C. J. West, R. M. Pountos, I. Giannoudis, P. V. J Clin Med 2021

complications
hip fractures
mortality
subtrochanteric

Predicting Delirium Risk Using an Automated Mayo Delirium Prediction Tool: Development and Validation of a Risk-Stratification Model Pagali, S. R. Miller, D. Fischer, K. Schroeder, D. Egger, N. Manning, D. M. Lapid, M. I. Pignolo, R. J. Burton, M. C. Mayo Clin Proc 2021

Aged
Aged, 80 and over
Clinical Decision Rules
Delirium/ diagnosis/ etiology
Female
Health Status Indicators
Hospitalization
Humans
Logistic Models
Male
Middle Aged
Reproducibility of Results
Retrospective Studies
Risk Assessment
Risk Factors

Effectiveness of Quetiapine as a Sedative Adjunct in Mechanically Ventilated Adults Without Delirium Ohman, K. L. Schultheis, J. M. Kram, S. J. Cox, C. E. Gilstrap, D. L. Yang, Z. Kram, B. L. Ann Pharmacother 2021

Adjuvants, Pharmaceutic/administration & dosage/ therapeutic use
Adult
Analgesics, Opioid/administration & dosage/therapeutic use
Benzodiazepines/administration & dosage/therapeutic use
Cohort Studies
Delirium
Dexmedetomidine/administration & dosage/therapeutic use
Dose-Response Relationship, Drug
Female
Humans
Hypnotics and Sedatives/administration & dosage/ therapeutic use
Intensive Care Units
Male
Middle Aged
Pain/drug therapy
Propofol/administration & dosage/therapeutic use
Quetiapine Fumarate/ therapeutic use
Respiration, Artificial
Retrospective Studies
antipsychotics
antipsychotics (atypical)
critical care
mechanical
sedatives
ventilators

Development of a postoperative delirium risk scoring tool using data from the Australian and New Zealand Hip Fracture Registry: an analysis of 6672 patients 2017-2018 Oberai, T. Oosterhoff, J. H. F. Woodman, R. Doornberg, J. N. Kerkhoffs, G. Jaarsma, R. Arch Gerontol Geriatr 2021

Aged, 80 and over
Australia/epidemiology
Delirium/diagnosis/epidemiology/etiology
Hip Fractures/epidemiology/surgery
Humans
Male
New Zealand/epidemiology
Postoperative Complications/epidemiology/etiology
Registries
Risk Factors
Tool Use Behavior
Delirium
hip fractures
multivariate
risk score

Does implementation of a tailored intervention increase adherence to a National Safety and Quality Standard? A study to improve delirium care Oberai, T. Laver, K. Woodman, R. Crotty, M. Kerkhoffs, G. Jaarsma, R. Int J Qual Health Care 2021

elderly
health policy
hospital care
quality improvement
standards

Delirium in Burn Patients: Developing a Mobile Application for Assessment and Diagnosis Mohseni Moallem Kolaei, N. Ayatollahi, H. Elyasi, F. J Burn Care Res 2021
Combination of delirium and coma predicts psychiatric symptoms at twelve months in critically ill patients: A longitudinal cohort study Miyamoto, K. Shibata, M. Shima, N. Nakashima, T. Kida, M. Matsumoto, H. Oka, N. Yazaki, A. Uchigaki, A. Takemoto, A. Kato, S. J Crit Care 2021

Activity of daily living disability
Coma
Delirium
Post intensive care syndrome
Psychiatric symptoms

Implementation of the Family HELP Protocol: A Feasibility Project for a West Texas ICU McClay, R. Healthcare (Basel) 2021

Icu
bedside nurse
critical care
delirium
family HELP
hospital elder life program

Prevention and Management of Delirium in the Intensive Care Unit Mart, M. F. Williams Roberson, S. Salas, B. Pandharipande, P. P. Ely, E. W. Semin Respir Crit Care Med 2021
Haloperidol for preventing delirium in ICU patients: a systematic review and meta-analysis Marra, A. Vargas, M. Buonanno, P. Iacovazzo, C. Kotfis, K. Servillo, G. Eur Rev Med Pharmacol Sci 2021

Delirium
Disorders
Factors
Prospective
Trauma

Delirium in trauma patients: a 1-year prospective cohort study of 2026 patients Marquetand, J. Gehrke, S. Bode, L. Fuchs, S. Hildenbrand, F. Ernst, J. von Känel, R. Boettger, S. Eur J Trauma Emerg Surg 2021

Delirium
Disorders
Factors
Prospective
Trauma

Subsyndromal Delirium in Cardiac Surgery Patients: Risk Factors and Outcomes of the Different Trajectories Mailhot, T. Cossette, S. Maheu-Cadotte, M. A. Fontaine, G. Denault, A. Y. J Cardiovasc Nurs 2021
Low-Dose Trazodone for Delirium in Patients with Cancer Who Received Specialist Palliative Care: A Multicenter Prospective Study Maeda, I. Inoue, S. Uemura, K. Tanimukai, H. Hatano, Y. Yokomichi, N. Amano, K. Tagami, K. Yoshiuchi, K. Ogawa, A. Iwase, S J Palliat Med 2021

cancer
delirium
palliative care units
psycho-oncology
trazodone

Preoperative anxiety predicted the incidence of postoperative delirium in patients undergoing total hip arthroplasty: a prospective cohort study Ma, J. Li, C. Zhang, W. Zhou, L. Shu, S. Wang, S. Wang, D. Chai, X. BMC Anesthesiol 2021

Anxiety
Cognitive ability
Delirium
Hip surgery

Perioperative Dexmedetomidine Supplement Decreases Delirium Incidence After Adult Cardiac Surgery: A Randomized, Double-Blind, Controlled Study Likhvantsev, V. V. Landoni, G. Grebenchikov, O. A. Ovezov, A. M. Skripkin, Y. V. Lembo, R. Gaevskiy, D. I. Tereshina, A. A. Yavorovskiy, A. G. J Cardiothorac Vasc Anesth 2021

Adult
Cardiac Surgical Procedures/adverse effects
Delirium/epidemiology/prevention & control
Dexmedetomidine
Double-Blind Method
Humans
Hypnotics and Sedatives/adverse effects
Incidence
anesthesia
cardiac surgery
cardiopulmonary bypass
outcomes
postoperative delirium

An observational study of hypoactive delirium in the post-anesthesia recovery unit of a pediatric hospital Lee-Archer, P. F. von Ungern-Sternberg, B. S. Reade, M. C. Law, K. C. Long, D. Paediatr Anaesth 2021

emergence delirium
pediatrics
postoperative complications

A prospective observational cohort pilot study of the association between midazolam use and delirium in elderly endoscopy patients Lee, D. Petersen, F. Wu, M. Chapman, G. Hayman, M. Tomkins, K. Fernando, J. BMC Anesthesiol 2021

Anaesthesia
Delirium
Elderly
Endoscopy
Midazolam
Sedation

Discharge from hospital with newly administered antipsychotics after intensive care unit delirium - Incidence and contributing factors Lambert, J. Vermassen, J. Fierens, J. Peperstraete, H. Petrovic, M. Colpaert, K. J Crit Care 2021

Antipsychotics
Delirium
Haloperidol
Intensive care unit
Polypharmacy
Transitions of care

Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis Hughes, C. G. Mailloux, P. T. Devlin, J. W. Swan, J. T. Sanders, R. D. Anzueto, A. Jackson, J. C. Hoskins, A. S. Pun, B. T. Orun, O. M. Raman, R. Stollings, J. L. Kiehl, A. L. Duprey, M. S. Bui, L. N. O'Neal, H. R., Jr. Snyder, A. Gropper, M. A. Guntupall N Engl J Med 2021

Adult
Cognition/drug effects
Conscious Sedation/ methods
Critical Illness
Dexmedetomidine/administration & dosage
Double-Blind Method
Humans
Hypnotics and Sedatives/administration & dosage/adverse effects
Kaplan-Meier Estimate
Propofol/administration & dosage
Respiration, Artificial
Sepsis/mortality/ therapy

Repeated Preoperative Intranasal Administration of Insulin Decreases the Incidence of Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Radical Gastrointestinal Surgery: A Randomized, Placebo-Controlled, Double-Blinded Clinical Study Huang, Q. Li, Q. Qin, F. Yuan, L. Lu, Z. Nie, H. Gong, G. Am J Geriatr Psychiatry 2021

Postoperative delirium
elderly
insulin
intranasal

The diagnostic threshold of Cornell assessment of pediatric delirium in detection of postoperative delirium in pediatric surgical patients Hong, H. Guo, C. Liu, Z. H. Wang, B. J. Zhou, S. Z. Mu, D. L. Wang, D. X. BMC Pediatr 2021

Child
Child, Preschool
Critical Illness
Delirium/diagnosis
Diagnostic and Statistical Manual of Mental Disorders
Humans
Prospective Studies
Reproducibility of Results
Chinese version
Cornell assessment of pediatric delirium
Pediatric delirium
Surgery
Threshold

Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial Hollinger, A. Rüst, C. A. Riegger, H. Gysi, B. Tran, F. Brügger, J. Huber, J. Toft, K. Surbeck, M. Schmid, H. R. Rentsch, K. Steiner, L. Siegemund, M. J Clin Anesth 2021

Adult
Cognitive Dysfunction/etiology/prevention & control
Delirium/prevention & control
Double-Blind Method
Haloperidol/adverse effects
Humans
Ketamine
Cortisol
Dos
Mmse
Nse
Nu-DESC
S100β

Delirium care knowledge in critical care nurses: A multiple-choice question-based quiz Ho, M. H. Traynor, V. Chen, K. H. Montayre, J. Lin, Y. K. Chang, H. R. Nurs Crit Care 2021

critical care nursing
delirium
evidence-based practice
instrument development
knowledge

Comparison of hospital course and outcome in hospital-acquired vs pre-existing delirium Guillory, J. Fitz-Gerald, C. Banik, A. Sterwald, C. Ashiofu, E. Knox, E. Muyco, M. A. Verlage, M. Abdali, A. O'Malley, P. W. Rezai, A. Bush, P. Brown, E. S. North, C. S. Ann Clin Psychiatry 2021
Dexmedetomidine reduces postoperative cognitive and behavioral dysfunction in adults submitted to general anesthesia for non-cardiac surgery: meta-analysis of randomized clinical trials Govêia, C. S. Miranda, D. B. Oliveira, L. V. B. Praxedes, F. B. Moreira, L. G. Guimarães, G. M. N. Braz J Anesthesiol 2021

Delirium
Dexmedetomidine
General anesthesia
Meta-analysis
Psychomotor agitation

An exploration of the reliability and usability of two delirium screening tools in an Australian intensive care unit: A pilot study Ewers, R. Bloomer, M. J. Hutchinson, A. Intensive Crit Care Nurs 2021

Confusion assessment methods -ICU
Delirium
Delirium screening tools
Intensive CARE Delirium Screening Checklist
Intensive care units
Nursing assessment

Haloperidol and Quetiapine for the Treatment of ICU-Associated Delirium in a Tertiary Pediatric ICU: A Propensity Score-Matched Cohort Study Cronin, M. T. Di Gennaro, J. L. Watson, R. S. Dervan, L. A. Paediatr Drugs 2021

Antipsychotic Agents/therapeutic use
Child
Cohort Studies
Delirium/ drug therapy
Female
Haloperidol/ administration & dosage/adverse effects
Humans
Intensive Care Units, Pediatric
Male
Propensity Score
Quetiapine Fumarate/ therapeutic use
Respiration, Artificial
Retrospective Studies

Post-operative delirium in older hip fracture patients: a new onset or was it already there? Costa-Martins, I. Carreteiro, J. Santos, A. Costa-Martins, M. Artilheiro, V. Duque, S. Campos, L. Chedas, M. Eur Geriatr Med 2021

Cognitive assessment
Hip fracture
Post-operative delirium
Pre-operative delirium

The Use of Tablet Computers to Reduce Preoperative Anxiety in Children Before Anesthesia: A Randomized Controlled Study Clausen, N. G. Madsen, D. Rosenkilde, C. Hasfeldt-Hansen, D. Larsen, L. G. Hansen, T. G. J Perianesth Nurs 2021

emergence delirium
general anesthesia
pediatric anesthesia
preoperative anxiety

A gap existed between physicians' perceptions and performance of pain, agitation-sedation and delirium assessments in Chinese intensive care units Chen, K. Yang, Y. L. Li, H. L. Xiao, D. Wang, Y. Zhang, L. Zhou, J. X. BMC Anesthesiol 2021

Analgesia
Critical care
Practice
Prevalence
Sedation
Survey

Association of Depressive Symptoms With Postoperative Delirium and CSF Biomarkers for Alzheimer's Disease Among Hip Fracture Patients Chan, C. K. Sieber, F. E. Blennow, K. Inouye, S. K. Kahn, G. Leoutsakos, J. S. Marcantonio, E. R. Neufeld, K. J. Rosenberg, P. B. Wang, N. Y. Zetterberg, H. Lyketsos, C. G. Oh, E. S. Am J Geriatr Psychiatry 2021

Alzheimer’s disease
amyloid
csf
delirium
depression
hip fracture
mild behavioral impairment
tau

Delirium as a predictor of mortality and disability among hospitalized patients in Zambia Banerdt, J. K. Mateyo, K. Wang, L. Lindsell, C. J. Riviello, E. D. Saylor, D. Heimburger, D. C. Ely, E. W. PLoS One 2021
Incidence and Risk Factors of Emergence Delirium after Anesthesia in Elderly Patients at a Postanesthesia Care Unit in Ethiopia: Prospective Observational Study Assefa, M. T. Chekol, W. B. Melesse, D. Y. Nigatu, Y. A. Patient Relat Outcome Meas 2021

delirium
emergence delirium
incidence and associated factors
postanesthesia care

Impact of SARS-CoV-2 Infection on Cognitive Function: A Systematic Review Alnefeesi, Y. Siegel, A. Lui, L. M. W. Teopiz, K. M. Ho, R. C. M. Lee, Y. Nasri, F. Gill, H. Lin, K. Cao, B. Rosenblat, J. D. McIntyre, R. S. Front Psychiatry 2021

Covid-19
brain health
cognitive function
cytokines
delirium
depression
neuroinflammation
neurotropism

Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study Zhou, J. Liu, C. Sun, Y. Huang, W. Ye, K. Brain Behav Immun 2021

Adult
Aged
Angiotensin-Converting Enzyme 2/genetics/metabolism
Biomarkers/blood
COVID-19/ psychology
Cognition
Cognitive Dysfunction/ physiopathology
Cohort Studies
European Continental Ancestry Group/genetics
Female
Hospitalization/ trends
Humans
Male
Middle Aged
Pandemics
Risk Factors
SARS-CoV-2/genetics/metabolism
Serine Endopeptidases/genetics/metabolism
Alzheimer’s disease
Covid-19
Cognitive disorders
Dementia
Pre-existing conditions
Risk factors

Probable delirium is a presenting symptom of COVID-19 in frail, older adults: a cohort study of 322 hospitalised and 535 community-based older adults Zazzara, M. B. Penfold, R. S. Roberts, A. L. Lee, K. A. Dooley, H. Sudre, C. H. Welch, C. Bowyer, R. C. E. Visconti, A. Mangino, M. Freidin, M. B. El-Sayed Moustafa, J. S. Small, K. S. Murray, B. Modat, M. Graham, M. S. Wolf, J. Ourselin, S. Martin, F. C. Age Ageing 2021

Aged
COVID-19/epidemiology/psychology/therapy
COVID-19 Nucleic Acid Testing/methods/statistics & numerical data
Cohort Studies
Delirium/diagnosis/epidemiology/etiology
Female
Frail Elderly
Frailty/diagnosis/epidemiology/etiology
Geriatric Assessment/methods
Hospitalization/statistics & numerical data
Humans
London/epidemiology
Male
Prevalence
Risk Assessment/ methods
Risk Factors
SARS-CoV-2/ isolation & purification
Covid-19
delirium
frailty
older people

Association between intensive care unit delirium and delusional memory after critical care in mechanically ventilated patients Yoshino, Y. Unoki, T. Sakuramoto, H. Ouchi, A. Hoshino, H. Matsuishi, Y. Mizutani, T. Nurs Open 2021

delirium
delusional memory
intensive care unit
mechanical ventilation

Delirium screening for patients in the intensive care unit: A prospective validation study of the iCAM-ICU by nurse researchers and bedside nurses in routine practice Yang, F. Ji, M. Wu, Y. Feng, Y. Li, J. Ren, D. Ely, E. W. Int J Nurs Stud 2021

Confusion
Delirium assessment
Diagnostic accuracy
Health information technology
Sensitivity and specificity

Six-Minute Walk Test Predicts Postoperative Delirium After Transcatheter Aortic Valve Replacement Yamashita, A. Suzuki, S. Otsuka, T. Matsuda, H. Ando, H. Sugimura, K. Maekawa, E. Meguro, K. Ako, J. Okamoto, H. J Cardiothorac Vasc Anesth 2021

Clinical Frailty Scale
postoperative delirium
six-minute walk test
transcatheter aortic valve replacement

Topological data analysis (TDA) enhances bispectral EEG (BSEEG) algorithm for detection of delirium Yamanashi, T. Kajitani, M. Iwata, M. Crutchley, K. J. Marra, P. Malicoat, J. R. Williams, J. C. Leyden, L. R. Long, H. Lo, D. Schacher, C. J. Hiraoka, K. Tsunoda, T. Kobayashi, K. Ikai, Y. Kaneko, K. Umeda, Y. Kadooka, Y. Shinozaki, G. Sci Rep 2021
New Cutoff Scores for Delirium Screening Tools to Predict Patient Mortality Yamanashi, T. Iwata, M. Crutchley, K. J. Sullivan, E. J. Malicoat, J. R. Anderson, Z. M. Marra, P. S. Chang, G. Kaneko, K. Shinozaki, E. Lee, S. Shinozaki, G. J Am Geriatr Soc 2021

Cam-icu
Doss
Drs-r-98
delirium
mortality

Intraoperative dexmedetomidine for prevention of postoperative delirium in elderly patients with mild cognitive impairment Xin, X. Chen, J. Hua, W. Wang, H. Int J Geriatr Psychiatry 2021

Aged
Anesthesia, General
Cognitive Dysfunction/etiology/prevention & control
Delirium/prevention & control
Dexmedetomidine/therapeutic use
Humans
Postoperative Complications/prevention & control
blood‐brain barrier
dexmedetomidine
elderly
mild cognitive impairment
neuroinflammation
postoperative delirium

The risk factors for postoperative delirium in adult patients after hip fracture surgery: a systematic review and meta-analysis Wu, J. Yin, Y. Jin, M. Li, B. Int J Geriatr Psychiatry 2021

Blood Transfusion
Delirium/epidemiology/etiology
Hip Fractures/surgery
Humans
Incidence
Postoperative Complications/epidemiology
Risk Factors
adult patients
hip fracture surgery
postoperative delirium

Preoperative Delirium Nursing Model Initiatives to Determine the Incidence of Postoperative Delirium Among Elderly Orthopaedic Patients Wu, H. Kapur, A. Gibson, B. Bubb, K. Alrawashdeh, M. Cipkala-Gaffin, J. Orthop Nurs 2021
Challenges of Delirium Management in Patients with Traumatic Brain Injury: From Pathophysiology to Clinical Practice Williams Roberson, S. Patel, M. B. Dabrowski, W. Ely, E. W. Pakulski, C. Kotfis, K. Curr Neuropharmacol 2021

barbiturates
critical care
delirium
dexmedetomidine
electroencephalography
post-traumatic delirium
traumatic brain injury
xanthohumol

A Systematic Review of Delirium Biomarkers and Their Alignment with the NIA-AA Research Framework Wang, S. Lindroth, H. Chan, C. Greene, R. Serrano-Andrews, P. Khan, S. Rios, G. Jabbari, S. Lim, J. Saykin, A. J. Khan, B. J Am Geriatr Soc 2021

Alzheimerʼs disease
biomarkers
delirium
inflammation
mild cognitive impairment
neuroimaging
preclinical Alzheimerʼʼs disease

Development and validation of the Terminal Delirium-Related Distress Scale to assess irreversible terminal delirium Uchida, M. Akechi, T. Morita, T. Shima, Y. Igarashi, N. Miyashita, M. Palliat Support Care 2021

Cancer
Delirium
End of life
Palliative care
Terminal delirium

Targeted metabolomics analysis of postoperative delirium Tripp, B. A. Dillon, S. T. Yuan, M. Asara, J. M. Vasunilashorn, S. M. Fong, T. G. Metzger, E. D. Inouye, S. K. Xie, Z. Ngo, L. H. Marcantonio, E. R. Libermann, T. A. Otu, H. H. Sci Rep 2021
Hospitalized older adult: predictors of functional decline Tavares, J. P. A. Nunes, Lanv Grácio, J. C. G. Rev Lat Am Enfermagem 2021

Activities of Daily Living
Aged
Aged, 80 and over
Delirium
Female
Hospitalization
Humans
Male
Patient Discharge
Prospective Studies
Risk Factors

Postoperative delirium in patients undergoing tumor resection with reconstructive surgery for oral cancer Takahashi, N. Hiraki, A. Kawahara, K. Nagata, M. Yoshida, R. Matsuoka, Y. Tanaka, T. Obayashi, Y. Sakata, J. Nakashima, H. Arita, H. Shinohara, M. Nakayama, H. Mol Clin Oncol 2021

early postoperative ambulation
oral cancer
postoperative delirium
reconstructive surgery
tumor resection

Prevalence of ICU Delirium in Postoperative Pediatric Cardiac Surgery Patients Staveski, S. L. Pickler, R. H. Khoury, P. R. Ollberding, N. J. Donnellan, A. L. Mauney, J. A. Lincoln, P. A. Baird, J. D. Gilliland, F. L. Merritt, A. D. Presnell, L. B. Lanese, A. R. Lisanti, A. J. Large, B. J. Fineman, L. D. Gibson, K. H. Mohler, L. A. Pediatr Crit Care Med 2021

Adolescent
Cardiac Surgical Procedures/adverse effects
Child
Delirium/diagnosis/epidemiology/etiology
Humans
Intensive Care Units, Pediatric
North America/epidemiology
Prevalence
Prospective Studies
Risk Factors

Physostigmine for prevention of postoperative delirium and long-term cognitive dysfunction in liver surgery: A double-blinded randomised controlled trial Spies, C. D. Knaak, C. Mertens, M. Brockhaus, W. R. Shadenok, A. Wiebach, J. Kunzmann, K. Feldheiser, A. Pratschke, J. Müller, O. Kipping, V. Fabian, M. Abels, W. Borchers, F. Akyüz, L. Ely, E. W. Wernecke, K. D. Menon, D. K. Piper, S. K. Eur J Anaesthesiol 2021
Intraoperative clonidine to prevent postoperative emergence delirium following sevoflurane anesthesia in pediatric patients: a randomized clinical trial Sousa-Júnior, F. A. Souza, A. S. R. Lima, L. C. Santos Í, G. M. Menezes, L. A. P. Ratis, Papl Couceiro, T. C. M. Braz J Anesthesiol 2021

Anesthesia
Children
Clonidine
Emergence delirium
Psychomotor agitation
Tonsillectomy

Training hospital inpatient nursing to know (THINK) delirium: A nursing educational program Solberg, L. M. Campbell, C. S. Jones, K. Vaughn, I. Suryadevara, U. Fernandez, C. Shorr, R. Geriatr Nurs 2021

Delirium
Dementia
Non-pharmacologic interventions
Nursing education

Delirium is associated with an increased morbidity and in-hospital mortality in cancer patients: Results from a prospective cohort study Seiler, A. Blum, D. Deuel, J. W. Hertler, C. Schettle, M. Zipser, C. M. Ernst, J. Schubert, M. von Känel, R. Boettger, S. Palliat Support Care 2021

Cancer patients
Delirium
Morbidity
Mortality
Precipitating factors
Predisposing factors

Delirium Triage Screen/Brief Confusion Assessment Method in Adult Orthopaedic and Hematological Patients: A Validation Study Sederstrom, J. R. Aliory, C. D. Hanneman, E. M. Buras, M. R. Orthop Nurs 2021
"SQiD, the Single Question in Delirium; can a single question help clinicians to detect delirium in hospitalised cancer patients?" running heading Single Question in Delirium" (Bcan-D-20-01665) Sands, M. B. Sharma, S. Carpenter, L. Hartshorn, A. Lee, J. T. Lujic, S. Congdon, M. E. Buchanan, A. M. Agar, M. Vardy, J. L. BMC Cancer 2021

Cancer
Delirium
Detection
Hospital
Oncology
Screening

Factors Impacting Early Mobilization Following Hip Fracture: An Observational Study Said, C. M. Delahunt, M. Ciavarella, V. Al Maliki, D. Boys, A. M. Vogrin, S. Berney, S. J Geriatr Phys Ther 2021
Risk factors of postoperative delirium in the knee and hip replacement patients: a systematic review and meta-analysis Rong, X. Ding, Z. C. Yu, H. D. Yao, S. Y. Zhou, Z. K. J Orthop Surg Res 2021

Hip replacement
Knee replacement
Postoperative delirium
Risk factors

Characteristics of Younger and Older Adults with Hospital-Acquired Delirium: a Claims Data Study Spanning 14 years Rohatgi, N. Weng, Y. Ahuja, N. Lansberg, M. G. J Gen Intern Med 2021

Aged
Delirium/diagnosis/epidemiology
Geriatric Assessment
Hospitals
Humans

Factors Associated with Hospital-Acquired Delirium in Patients 18-65 Years Old Rohatgi, N. Weng, Y. Ahuja, N. Lansberg, M. G. J Gen Intern Med 2021

Adolescent
Adult
Aged
Delirium/diagnosis/epidemiology
Hospitalization
Hospitals
Humans
Middle Aged
Risk Factors
Young Adult

Implementation of a multicomponent intervention sign to reduce delirium in orthopaedic inpatients (MIND-ORIENT): a quality improvement project Reppas-Rindlisbacher, C. Siddhpuria, S. Wong, E. K. Lee, J. Y. Gabor, C. Curkovic, A. Khalili, Y. Mavrak, C. De Freitas, S. Eshak, K. Patterson, C. BMJ Open Qual 2021

evidence-based practice
geriatrics
healthcare quality improvement
hip fractures
nurses

Anticholinergic Burden Does Not Influence Delirium Subtype or the Delirium-Mortality Association in Hospitalized Older Adults: Results from a Prospective Cohort Study Rawle, M. J. McCue, L. Sampson, E. L. Davis, D. Vickerstaff, V. Drugs Aging 2021
Incidence and Risk Factors of Delirium in the Intensive Care Unit: A Prospective Cohort Rahimi-Bashar, F. Abolhasani, G. Manouchehrian, N. Jiryaee, N. Vahedian-Azimi, A. Sahebkar, A. Biomed Res Int 2021

Adult
Analgesics/administration & dosage
Anti-Bacterial Agents/administration & dosage
Delirium/diagnosis/ epidemiology/mortality
Female
Humans
Hypnotics and Sedatives/administration & dosage
Incidence
Intensive Care Units
Male
Middle Aged
Prospective Studies
Risk Factors
Severity of Illness Index

Implementing Delirium Prevention in the Era of COVID-19 Radhakrishnan, N. S. Mufti, M. Ortiz, D. Maye, S. T. Melara, J. Lim, D. Rosenberg, E. I. Price, C. C. J Alzheimers Dis 2021

Aged
Alzheimer Disease/ diagnosis/psychology/ therapy
COVID-19/epidemiology/ prevention & control/psychology
Delirium/epidemiology/ prevention & control/psychology
Humans
Male
Alzheimer’s disease
Covid-19
dementia
hospitalization
quality of health care
tertiary care centers

Prevalence and risk factors of delirium in psychogeriatric outpatients Quispel-Aggenbach, D. W. P. Schep-de Ruiter, E. P. R. van Bergen, W. Bolling, J. R. Zuidema, S. U. Luijendijk, H. J. Int J Geriatr Psychiatry 2021

Aged
Delirium/epidemiology/etiology
Geriatric Psychiatry
Humans
Outpatients
Prevalence
Risk Factors
delirium
elderly
older patient

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study Pun, B. T. Badenes, R. Heras La Calle, G. Orun, O. M. Chen, W. Raman, R. Simpson, B. K. Wilson-Linville, S. Hinojal Olmedillo, B. Vallejo de la Cueva, A. van der Jagt, M. Navarro Casado, R. Leal Sanz, P. Orhun, G. Ferrer Gómez, C. Núñez Vázquez, K. Pi Lancet Respir Med 2021

Aged
COVID-19/ psychology
Coma/ epidemiology/virology
Critical Illness/psychology
Delirium/ epidemiology/virology
Female
Humans
Hypnotics and Sedatives/therapeutic use
Intensive Care Units/statistics & numerical data
Male
Middle Aged
Prevalence
Respiration, Artificial/psychology/statistics & numerical data
Retrospective Studies
Risk Factors
SARS-CoV-2

Risk prediction models for emergence delirium in paediatric general anaesthesia: a systematic review Petre, M. A. Saha, B. Kasuya, S. Englesakis, M. Gai, N. Peliowski, A. Aoyama, K. BMJ Open 2021

Anesthesia, General/ adverse effects
Bias
Child
Cognition/ drug effects
Cognition Disorders/chemically induced
Emergence Delirium/ chemically induced/diagnosis
Humans
Risk Assessment
Surgical Procedures, Operative
Delirium & cognitive disorders
Paediatric anaesthesia
emergence delirium

The Effects of Propofol or Dexmedetomidine Sedation on Postoperative Recovery in Elderly Patients Receiving Lower Limb Surgery under Spinal Anesthesia: A Retrospective Propensity Score-Matched Analysis Park, J. W. Kim, E. K. Lee, H. T. Park, S. Do, S. H. J Clin Med 2021

dexmedetomidine
intraoperative sedation
postoperative delirium
propofol

High proportion of thiamine deficiency in referred cancer patients with delirium: a retrospective descriptive study Onishi, H. Sato, I. Uchida, N. Takahashi, T. Furuya, D. Ebihara, Y. Yoshioka, A. Ito, H. Ishida, M. Eur J Clin Nutr 2021
Association between discontinuation of benzodiazepine receptor agonists and post-operative delirium among inpatients with liaison intervention: A retrospective cohort study Omichi, C. Ayani, N. Oya, N. Matsumoto, Y. Tanaka, M. Morimoto, T. Kadotani, H. Narumoto, J. Compr Psychiatry 2021

Benzodiazepines/adverse effects
Delirium/chemically induced/diagnosis/epidemiology
Humans
Inpatients
Receptors, GABA-A
Retrospective Studies
benzodiazepine receptor agonist
benzodiazepine withdrawal syndrome
consultation-liaison psychiatry
discontinuation
post-operative delirium

The Independent Association of Prestroke Psychiatric Symptoms and Acute Phase Delirium with Poststroke Mortality at One Year in Nigeria Ojagbemi, A. Bello, T. Owolabi, M. Baiyewu, O. J Stroke Cerebrovasc Dis 2021

Delirium/diagnosis/ mortality/psychology
Female
Humans
Longitudinal Studies
Male
Mental Disorders/diagnosis/ mortality/psychology
Mental Health
Middle Aged
Nigeria/epidemiology
Prognosis
Prospective Studies
Risk Assessment
Risk Factors
Stroke/diagnosis/ mortality/psychology
Surveys and Questionnaires
Time Factors
Mental health complications
Neurocognitive disorders
Prestroke symptoms
Stroke burden
Sub-Saharan Africa

Depression predicts long-term cognitive impairment in survivors of critical illness Nordness, M. F. Bipin Patel, M. Erickson, C. R. Kiehl, A. Jackson, J. C. Raman, R. Pandharipande, P. P. Ely, E. W. Wilson, J. E. J Trauma Acute Care Surg 2021

Aged
Cognitive Dysfunction/ etiology
Critical Illness/ psychology
Depression/ complications/etiology
Female
Humans
Intensive Care Units/statistics & numerical data
Male
Middle Aged
Neuropsychological Tests
Prospective Studies
Stress Disorders, Post-Traumatic/complications/etiology
Survivors/ psychology/statistics & numerical data

Effects of uncomfortable care and histamine H2-antagonists on delirium in acute stroke: A propensity score analysis Nakamizo, T. Kanda, T. Kudo, Y. Sugawara, E. Hashimoto, E. Okazaki, A. Usuda, M. Nagai, T. Hara, H. Johkura, K. J Neurol Sci 2021

Delirium/epidemiology/etiology
Histamine
Histamine H2 Antagonists
Humans
Intensive Care Units
Propensity Score
Prospective Studies
Stroke/complications/drug therapy
Adverse effect
Anti-ulcer agent
Clinical nursing research
Gastrointestinal haemorrhage
Immobilization
Indwelling catheter
Prevention and control
Sleep deprivation

Family automated voice reorientation (FAVoR) intervention for mechanically ventilated patients in the intensive care unit: Study protocol for a randomized controlled trial Munro, C. L. Liang, Z. Ji, M. Elías, M. N. Chen, X. Calero, K. Ely, E. W. Contemp Clin Trials 2021

Cognition
Critical illness
Delirium
Mechanical ventilation
Randomized controlled trial
Sleep

Evaluation of a delirium awareness podcast for undergraduate nursing students in Northern Ireland: a pre-/post-test study Mitchell, G. Scott, J. Carter, G. Wilson, C. B. BMC Nurs 2021

Constructivist pedagogy
Delirium
Nurse education
Nursing student
Pedagogical research
Podcast
Quantitative research methods

Impact of delirium in acute cardiac care unit after transcatheter aortic valve replacement Luque, T. Noriega, F. J. McInerney, A. Travieso, A. Corrochano, D. Tirado-Conte, G. Ferrera, C. Fossati, S. Jimenez-Quevedo, P. Nuñez-Gil, I. Gonzalo, N. Escaned, J. Macaya, C. Fernández-Ortiz, A. Nombela-Franco, L. Viana-Tejedor, A. Int J Cardiol 2021

Aortic Valve/surgery
Aortic Valve Stenosis/surgery
Delirium/diagnosis/epidemiology/etiology
Humans
Length of Stay
Postoperative Complications/diagnosis/epidemiology
Risk Factors
Transcatheter Aortic Valve Replacement/adverse effects
Treatment Outcome
Acute cardiac care
Aortic stenosis
Delirium
Transcatheter aortic valve replacement

Preoperative Prognostic Nutritional Index Value is Related to Postoperative Delirium in Elderly Patients After Noncardiac Surgery: A Retrospective Cohort Study Liu, H. Dai, M. Guan, H. Gao, X. Zhou, Y. Sun, X. Zhou, J. Hu, X. Li, X. Song, Y. Han, Y. Cao, J. Risk Manag Healthc Policy 2021

elderly patients
noncardiac surgery
nutritional status
postoperative delirium
prognostic nutritional index