What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Strategies to prevent postoperative delirium: a comprehensive evaluation of anesthesia selection and drug intervention
- Authors
- Lan, S. Liang, S. Wu, H. Deng, S. Sun, K. Ye, C. Yang, L. Ciren, L. Li, J.
- Year
- 2024
- Journal
- Front Psychiatry
- Abstract
Postoperative delirium (POD) represents a common neurological complication encountered predominantly among the elderly cohort undergoing surgical intervention for hip fractures. This phenomenon, particularly commonplace in geriatric populations with heightened preoperative risk profiles, pronounced comorbidities, and later stages of lifespan, poses complex clinical challenges. The impact of perioperative pharmacological interventions and anesthetic strategies on POD’s emergence cannot be understated, as it may profoundly affect the length of hospital stays, rehabilitation milestones, and the overall mortality hazard. The pharmacotherapeutic landscape for managing POD remains constrained, underscoring the imperative nature of preventive measures. Prudent preoperative risk stratification, meticulous intraoperative neuromonitoring guided by electroencephalographic studies, and a holistic postoperative patient welfare model are cornerstone recommendations in the quest to mitigate POD’s incidence. Nonetheless, an extensive exploration into the influence of anesthetic approaches and perioperative medications on the emergence of POD is yet to be satisfactorily charted. Our investigation endeavors to dissect the nexus between anesthetic modalities, perioperative pharmacological interventions, and POD incident rates among the elderly with hip fractures. This study spotlights pivotal determinants of POD in the wake of hip fracture surgery by evaluating and synthesizing data from peer-reviewed sources that adhere to rigorous inclusion criteria. Preliminary studies have revealed that certain anesthesia protocols and perioperative medications may increase the potential incidence of POD, such as higher depth of anesthesia or benzodiazepine use, and the incidence of POD in specific populations, such as patients with higher age, prior history of psychosis, and lower intraoperative oxygen saturation The findings from this study are instrumental in refining strategic perioperative plans tailored for the elderly recipients of hip fracture surgery, aimed at not only diminishing the incidence but also the gravity of POD. Despite these forward steps, the clinical uncertainty concerning the efficacy and safety of the specific drugs and surgical techniques in question remains. These lingering questions underscore the exigency for more extensive, empirically grounded research to consolidate the learnings of this investigation.
- PMID
PMID: 39763689
PMCID: PMC11701066
- Keywords
anesthesia delirium hip fractures perioperative medication prevention treatment
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| The effects of intraoperative magnesium sulfate administration on emergence agitation and delirium in pediatric patients: a systematic review and meta-analysis of randomized controlled trials | Koo, C. H. Koo, B. W. Han, J. Lee, H. T. Lim, D. Shin, H. J. | Paediatr Anaesth | 2021 |
complications |
| The Modified Hospital Elder Life Program (HELP) in geriatric hospitalized patients in internal wards: A double-blind randomized control trial | Kojaie-Bidgoli, A. Sharifi, F. Maghsoud, F. Alizadeh-Khoei, M. Jafari, F. Sadeghi, F. | BMC Geriatr | 2021 |
Aged |
| The economic cost of delirium: A systematic review and quality assessment | Kinchin, I. Mitchell, E. Agar, M. Trépel, D. | Alzheimers Dement | 2021 |
Cost-Benefit Analysis/*economics |
| The Risk of Preoperative Central Nervous System-Acting Medications on Delirium Following Hip or Knee Surgery: A Matched Case-Control Study | Kassie, G. M. Roughead, E. E. Nguyen, T. A. Pratt, N. L. Kalisch Ellett, L. M. | Drug Saf | 2021 |
Preoperative Central Nervous System Delirium Hip or Knee Surgery Matched Case-Control Study |
| Association between ankle brachial index and development of postoperative intensive care unit delirium in patients with peripheral arterial disease | Kang, J. An, J. H. Jeon, H. J. Park, Y. J. | Sci Rep | 2021 |
Aged |
| Incidence and predictors of delirium on the intensive care unit in patients with acute kidney injury, insight from a retrospective registry | Jäckel, M. Aicher, N. Rilinger, J. Bemtgen, X. Widmeier, E. Wengenmayer, T. Duerschmied, D. Biever, P. M. Stachon, P. Bode, C. Staudacher, D. L. | Sci Rep | 2021 |
Acute Kidney Injury/*diagnosis/epidemiology |
| Advantages of score-based delirium detection compared to a clinical delirium assessment-a retrospective, monocentric cohort study | Jäckel, M. Aicher, N. Bemtgen, X. Rilinger, J. Zotzmann, V. Biever, P. M. Supady, A. Stachon, P. Duerschmied, D. Wengenmayer, T. Bode, C. Staudacher, D. L. | PLoS One | 2021 |
score-based delirium detection clinical delirium monocentric cohort study |
| A Comparison of Dexmedetomidine and Propofol on Emergence Delirium in Children Undergoing Cleft Palate Surgery With Sevoflurane-Based Anesthesia | Huang, L. Wang, L. Peng, W. Qin, C. | J Craniofac Surg | 2021 |
Emergence Delirium Children Cleft Palate Surgery Sevoflurane |
| Automated machine learning-based model predicts postoperative delirium using readily extractable perioperative collected electronic data | Hu, X. Y. Liu, H. Zhao, X. Sun, X. Zhou, J. Gao, X. Guan, H. L. Zhou, Y. Zhao, Q. Han, Y. Cao, J. L. | CNS Neurosci Ther | 2021 |
delirium |
| Feasibility of low-dose dexmedetomidine for prevention of postoperative delirium after intracranial operations: a pilot randomized controlled trial | He, X. Cheng, K. M. Duan, Y. Q. Xu, S. S. Gao, H. R. Miao, M. Y. Li, H. L. Chen, K. Yang, Y. L. Zhang, L. Gu, H. Q. Zhou, J. X. | BMC Neurol | 2021 |
Delirium |
| Reliability and validity of the Japanese version of the 4A's Test for delirium screening in the elderly patient | Hasegawa, T. Seo, T. Kubota, Y. Sudo, T. Yokota, K. Miyazaki, N. Muranaka, A. Hirano, S. Yamauchi, A. Nagashima, K. Iyo, M. Sakai, I. | Asian J Psychiatr | 2021 |
Attention |
| Neural autoantibodies in delirium | Hansen, N. Krasiuk, I. Titsch, T. | J Autoimmun | 2021 |
Cognitive dysfunction |
| Risk Factors for Delirium in the Palliative Care Population: A Systematic Review and Meta-Analysis | Guo, D. Lin, T. Deng, C. Zheng, Y. Gao, L. Yue, J. | Front Psychiatry | 2021 |
delirium |
| Incidence, risk factors, and consequences of emergence delirium after elective brain tumor resection | Gu, W. J. Zhou, J. X. Ji, R. Q. Zhou, L. Y. Wang, C. M. | Surgeon | 2021 |
Emergence delirium |
| A scientometric study of publications on delirium from 2001 to 2020 | Grover, S. Gupta, B. M | Asian J Psychiatr | 2021 |
Aged |
| The neuropsychological profile of delirium vulnerability: A systematic review and meta-analysis | Ghezzi, E. S. Ross, T. J. Sharman, R. Davis, D. Boord, M. S. Thanabalan, T. Thomas, J. Keage, H. A. D. | Neurosci Biobehav Rev | 2021 |
ageing |
| Cognitive Functionality of Patients with Delirium after Stroke | Dostović, Z. Ibrahimagić, OĆ Smajlović, D. Kunić, S. Čustović, A. | Psychiatr Danub | 2021 |
Cognition |
| Sleep quality and emergence delirium in children undergoing strabismus surgery: a comparison between preschool- and school-age patients | Do, W. Kim, H. S. Kim, S. H. Kang, H. Lee, D. Baik, J. Lee, H. J. Hong, J. M. | BMC Anesthesiol | 2021 |
*Emergence delirium |
| Multicomponent nursing program to prevent delirium in critically ill patients: a randomized clinical trial | Contreras, C. C. T. Esteban, A. N. P. Parra, M. D. Romero, M. K. R. Silva, C. G. D. Buitrago, N. P. D. | Rev Gaucha Enferm | 2021 |
*Critical Illness |
| Longitudinal validation of an electronic health record delirium prediction model applied at admission in COVID-19 patients | Castro, V. M. Hart, K. L. Sacks, C. A. Murphy, S. N. Perlis, R. H. McCoy, T. H., Jr. | Gen Hosp Psychiatry | 2021 |
Covid-19 |
| Independent, Differential Effects of Delirium on Disability and Mortality Risk After Hip Fracture | Cartei, A. Mossello, E. Ceccofiglio, A. Rubbieri, G. Polidori, G. Ranalli, C. Cammilli, A. Curcio, M. Cavallini, M. C. Mannarino, G. M. Ungar, A. Toccafondi, G. Peris, A. Marchionni, N. Rostagno, C. | J Am Med Dir Assoc | 2021 |
Delirium |
| Melatonin and melatonin-receptor agonists to prevent delirium in hospitalized older adults: An umbrella review | Blodgett, T. J. Blodgett, N. P. | Geriatr Nurs | 2021 |
Circadian Rhythm |
| Barriers to completing the 4AT for delirium and its clinical implementation in two hospitals: a mixed-methods study | Alhaidari, A. A. O. Matsis, K. P. | Eur Geriatr Med | 2021 |
Delirium |
| The relationship between sensory stimuli and the physical environment in complex healthcare settings: A systematic literature review | Bayramzadeh, S. Ahmadpour, S. Aghaei, P. | Intensive Crit Care Nurs | 2021 |
*Communication |
| Simultaneous bilateral total knee arthroplasty is safe and effective for patients in different ages | Ariga, A. Kohno, Y. Nakagawa, Y. Watanabe, T. Katagiri, H. Ohara, T. Shioda, M. Ozeki, N. Amemiya, M. Okawa, A. Sekiya, I. Koga, H. | J Orthop Sci | 2021 |
Age groups |
| Machine Learning Algorithm Using Electronic Chart-Derived Data to Predict Delirium After Elderly Hip Fracture Surgeries: A Retrospective Case-Control Study | Zhao, H. You, J. Peng, Y. Feng, Y. | Front Surg | 2021 |
delirium |
| The Effect of Data Length on the Assessment of Dynamic Cerebral Autoregulation with Transfer Function Analysis in Neurological ICU Patients | Zhang, W. Lu, H. Zhang, P. Mo, X. Ou, A. Liu, J. Zhong, J. | Neurocrit Care | 2021 |
Data length |
| Clinical Features and Outcomes of Neuropsychiatric Systemic Lupus Erythematosus in China | Zhang, S. Li, M. Zhang, L. Wang, Z. Wang, Q. You, H. Wang, Y. Li, M. Zeng, X. | J Immunol Res | 2021 |
Adult |
| Noncontact Monitoring of Heart Rate and Heart Rate Variability in Geriatric Patients Using Photoplethysmography Imaging | Yu, X. Laurentius, T. Bollheimer, C. Leonhardt, S. Antink, C. H. | IEEE J Biomed Health Inform | 2021 |
Aged |
| Non-Contact Measurement of Heart Rate Variability in Frail Geriatric Patients: Response to Early Geriatric Rehabilitation and Comparison with Healthy Old Community-Dwelling Individuals - A Pilot Study | Yu, X. Hoog Antink, C. Leonhardt, S. Bollheimer, L. C. Laurentius, T. | Gerontology | 2021 |
Frailty |
| Aggressive patient behaviours and unplanned nursing staff leave - is there an association? | Yu, J. J. Holbeach, E. | Int J Ment Health Nurs | 2021 |
Aggression |
| The Significant Prognostic Factors in Prolonged Intensive/High Care Unit Stay After Living Donor Liver Transplantation | Yoshiya, S. Harada, N. Tomiyama, T. Takeishi, K. Toshima, T. Iguchi, T. Itoh, S. Ninomiya, M. Yoshizumi, T. Mori, M. | Transplant Proc | 2021 |
Adult |
| Mode displaying mouse cursors for reducing input language mode confusion: Utility and user attitude evaluation | Yoo, T. Lee, H. Hyun, S. Park, W. | Appl Ergon | 2021 |
Confusion |
| Incidence and influencing factors of post-intensive care cognitive impairment | Yao, L. Li, Y. Yin, R. Yang, L. Ding, N. Li, B. Shen, X. Zhang, Z. | Intensive Crit Care Nurs | 2021 |
Apache |
| Validation of the Simplified Palliative Prognostic Index to Predict Survival for Advanced Cancer Patients in Home Hospice Setting | Yang, H. J. Yoon, S. J. Kim, J. S. Kim, S. S. Jung, J. G. Suh, W. Y. Lee, S. Kim, H. G. Lee, Y. W. | Korean J Fam Med | 2021 |
Hospice Care |
| Oral corticosteroid dosage and clinical presentation of psychiatric conditions after steroid use: A consultation-liaison psychiatry service's experience | Yagi, Y. Takahashi, Y. Ogata, Y. Yamana, H. Kumakura, Y. Ichihashi, K. Kasai, K. Kondo, S. | Neuropsychopharmacol Rep | 2021 |
consultation-liaison psychiatry |
| Machine learning-assisted screening for cognitive impairment in the emergency department | Yadgir, S. R. Engstrom, C. Jacobsohn, G. C. Green, R. K. Jones, C. M. C. Cushman, J. T. Caprio, T. V. Kind, A. J. H. Lohmeier, M. Shah, M. N. Patterson, B. W. | J Am Geriatr Soc | 2021 |
cognitive impairment |
| Effects of perioperative rosuvastatin on postoperative delirium in elderly patients: A randomized, double-blind, and placebo-controlled trial | Xu, X. Q. Luo, J. Z. Li, X. Y. Tang, H. Q. Lu, W. H. | World J Clin Cases | 2021 |
Elderly |
| Is Perioperative Dexmedetomidine Associated With a Reduced Risk of Perioperative Neurocognitive Disorders Following Cardiac Surgery? A Systematic Review and Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials | Xiong, X. Chen, D. Shi, J. | Front Med (Lausanne) | 2021 |
cardiac surgery |
| The effect of pre-operative methylprednisolone on postoperative delirium in elderly patients undergoing gastrointestinal surgery: a randomized, double-blind, placebo-controlled trial | Xiang, X. B. Chen, H. Wu, Y. L. Wang, K. Yue, X. Cheng, X. Q. | J Gerontol A Biol Sci Med Sci | 2021 |
Delirium |
| Social Determinants of Health and Delirium Occurrence and Duration in Critically Ill Adults | Wu, T. T. Zegers, M. Kooken, R. Griffith, J. L. Molnar, B. E. Devlin, J. W. van den Boogaard, M. | Crit Care Explor | 2021 |
delirium |
| Implementation of a Frailty Assessment and Targeted Care Interventions and Its Association with Reduced Postoperative Complications in Elderly Surgical Patients | Wilson, S. Sutherland, E. Razak, A. O'Brien, M. Ding, C. Nguyen, T. Rosenkranz, P. Sanchez, S. E. | J Am Coll Surg | 2021 |
Frailty, Postoperative outcomes, Geriatrics, Frailty assessment |
| Prevalence of Mimics and Severe Comorbidity in Patients with Clinically Suspected Transient Global Amnesia | Werner, R. Woehrle, J. C. | Cerebrovasc Dis | 2021 |
Adult |
| The risk of delirium and falls or fractures with the use of overactive bladder anticholinergic medications | Welk, B. Etaby, K. McArthur, E. Chou, Q. | Neurourol Urodyn | 2021 |
anticholinergics |
| Hospitalization Outcomes of Delirium in Patients Admitted to Acute Care Hospitals in Their Last Year of Life: A Population-Based Retrospective Cohort Study | Webber, C. Watt, C. L. Bush, S. H. Lawlor, P. G. Talarico, R. Tanuseputro, P. | J Pain Symptom Manage | 2021 |
Adult |
| Anticholinergics and clinical outcomes amongst people with pre-existing dementia: A systematic review | Wang, K. Alan, J. Page, A. T. Dimopoulos, E. Etherton-Beer, C. | Maturitas | 2021 |
Anticholinergic |
| Association Between Intraoperative Arterial Hypotension and Postoperative Delirium After Noncardiac Surgery: A Retrospective Multicenter Cohort Study | Wachtendorf, L. J. Azimaraghi, O. Santer, P. Linhardt, F. C. Blank, M. Suleiman, A. Ahn, C. Low, Y. H. Teja, B. Kendale, S. M. Schaefer, M. S. Houle, T. T. Pollard, R. J. Subramaniam, B. Eikermann, M. Wongtangman, K. | Anesth Analg | 2021 |
Intraoperative Arterial Hypotension, Postoperative delirium, Surgery, Anesthesia |
| Dynamic assessments of hepatic encephalopathy and ammonia levels predict mortality in acute-on-chronic liver failure | Verma, N. Dhiman, R. K. Choudhury, A. Taneja, S. Duseja, A. Singh, V. Al Mahtab, M. Devarbhavi, H. Shukla, A. Ning, Q. Hamid, S. S. Butt, A. S. Jafri, W. Tan, S. S. Hu, J. Zhongping, D. Treeprasertsuk, S. Lee, G. H. Ghazinyan, H. Lesmana, L. A. Sood, A. M | Hepatol Int | 2021 |
*Acute-On-Chronic Liver Failure |
| Evaluation of the impact of cataract surgery on cognitive function in very elderly patients: a prospective, observational study | Verdina, T. Stiro, F. Bruni, F. Spedicato, G. A. Mastropasqua, R. Cavallini, G. M. | Aging Clin Exp Res | 2021 |
6-item cognitive impairment test (6CIT) |
| Physiological Assessment of Delirium Severity: The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S) | van Sleuwen, M. Sun, H. Eckhardt, C. Neelagiri, A. Tesh, R. A. Westmeijer, M. Paixao, L. Rajan, S. Velpula Krishnamurthy, P. Sikka, P. Leone, M. J. Panneerselvam, E. Quadri, S. A. Akeju, O. Kimchi, E. Y. Westover, M. B. | Crit Care Med | 2021 |
van Sleuwen, M. |
| The effect of peri-operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non-cardiac surgical patients: a randomised, double-blind placebo-controlled trial | van Norden, J. Spies, C. D. Borchers, F. Mertens, M. Kurth, J. Heidgen, J. Pohrt, A. Mueller, A. | Anaesthesia | 2021 |
Aged |
| Rivastigmine for minor visual hallucinations in Parkinson's disease: A randomized controlled trial with 24 months follow-up | van Mierlo, T. J. M. Foncke, E. M. J. Post, B. Schmand, B. A. Bloem, B. R. van Harten, B. Tissingh, G. Munts, A. G. de Haan, R. J. de Bie, R. M. A. | Brain Behav | 2021 |
Cholinesterase Inhibitors |
| Effects of Orthogeriatric Care Models on Outcomes of Hip Fracture Patients: A Systematic Review and Meta-Analysis | Van Heghe, A. Mordant, G. Dupont, J. Dejaeger, M. Laurent, M. R. Gielen, E. | Calcif Tissue Int | 2021 |
Geriatric co-management |
| Automatic continuous EEG signal analysis for diagnosis of delirium in patients with sepsis | Urdanibia-Centelles, O. Nielsen, R. M. Rostrup, E. Vedel-Larsen, E. Thomsen, K. Nikolic, M. Johnsen, B. Møller, K. Lauritzen, M. Benedek, K. | Clin Neurophysiol | 2021 |
Automatic EEG |
| Evaluation of the effectiveness of delirium prevention care protocol for the patients with hip fracture: A randomised controlled study | Unal, N. Guvenc, G. Ilkin Naharci, M. | J Clin Nurs | 2021 |
nursing care |
| Association of poor sleep burden in middle age and older adults with risk for delirium during hospitalization | Ulsa, M. C. Zheng, X. Li, P. Gaba, A. Wong, P. M. Saxena, R. Scheer, F. Rutter, M. Akeju, O. Hu, K. Gao, L. | J Gerontol A Biol Sci Med Sci | 2021 |
Sleep health |
| Where should patients with or at risk of delirium be treated in an acute care system? Comparing the rates of delirium in patients receiving usual care vs alternative care: A systematic review and meta-analysis | Ukwuoma Ekeozor, C. Jeyaruban, D. Lasserson, D. | Int J Clin Pract | 2021 |
Critical Care |
| Restraint use in the acute-care hospital setting: A cross-sectional multi-centre study | Thomann, S. Zwakhalen, S. Richter, D. Bauer, S. Hahn, S. | Int J Nurs Stud | 2021 |
Cross-Sectional Studies |
| Immune, Blood Cell, and Blood Gas Biomarkers of Delirium in Elderly Individuals with Hip Fracture Surgery | Thisayakorn, P. Tangwongchai, S. Tantavisut, S. Thipakorn, Y. Sukhanonsawat, S. Wongwarawipat, T. Sirivichayakul, S. Maes, M. | Dement Geriatr Cogn Disord | 2021 |
Delirium |
| Delirium Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS) | Teng, C. Frei, C. R. | Drugs Real World Outcomes | 2021 |
Delirium, Antibiotics, FDA Adverse Event Reporting System |
| The Impact of Aging on Symptom Prevalence and Management in Terminally ill Patients With Cancer | Tatokoro, M. Matsuo, N. | J Pain Symptom Manage | 2021 |
Age |
| Subjective strain of care experienced by pulmonary and critical care medical nurses when caring for patients with delirium: a cross-sectional study | Tan, H. Zhou, L. Wu, S. Dong, Q. Yang, L. Xu, J. Zhao, S. Wang, X. Yang, H. | BMC Health Serv Res | 2021 |
Critical Care |
| Circulating MicroRNAs and Novel Proteins as Potential Biomarkers of Neurological Complications after Heart Bypass Surgery | Szwed, K. Szwed, M. Kozakiewicz, M. Karłowska-Pik, J. Soja-Kukieła, N. Bartoszewska, A. Borkowska, A. | J Clin Med | 2021 |
Cabg |
| Evaluation of the implementation of multidisciplinary fast-track program for acute geriatric hip fractures at a University Hospital in resource-limited settings | Sura-Amonrattana, U. Tharmviboonsri, T. Unnanuntana, A. Tantigate, D. Srinonprasert, V. | BMC Geriatr | 2021 |
Aged |
| Perceptions of current occupational therapy practice with older adults experiencing delirium | Strecker, C. Hitch, D. | Australas J Ageing | 2021 |
Aged |
| Changes in autonomic tone during delirium in acute stroke patients assessed by pupillometry and skin conductance | Stokholm, J. Birkmose, L. K. H. Ahmed, Aabo Csillag, C. Kjær, T. W. Christensen, T. | J Neurol Sci | 2021 |
Autonomic Nervous System |
| Expression of HO1 and PER2 can predict the incidence of delirium in trauma patients with concomitant brain injury | Steimer, M. Kaiser, S. Ulbrich, F. Kalbhenn, J. Bürkle, H. Schallner, N. | Sci Rep | 2021 |
Biomarkers, Circadian rhythms and sleep, Translational research, Neurological manifestations |
| An implementation science approach to geriatric screening in an emergency department | Southerland, L. T. Hunold, K. M. Van Fossen, J. Caterino, J. M. Gulker, P. Stephens, J. A. Bischof, J. J. Farrell, E. Carpenter, C. R. Mion, L. C. | J Am Geriatr Soc | 2021 |
Cfir |
| Effectiveness of the ABCDEF bundle on delirium, functional outcomes and quality of life in intensive care patients: a study protocol for a randomised controlled trial with embedded process evaluation | Sosnowski, K. Mitchell, M. Cooke, M. White, H. Morrison, L. Lin, F. | BMJ Open | 2021 |
Critical Care |
| Effects of general versus subarachnoid anaesthesia on circadian melatonin rhythm and postoperative delirium in elderly patients undergoing hip fracture surgery: A prospective cohort clinical trial | Song, Y. Liu, Y. Yuan, Y. Jia, X. Zhang, W. Wang, G. Jia, Y. Wang, X. Liu, L. Li, W. Li, X. Cai, N. Liu, C. Li, Y. Han, Y. Zhou, Y. Mi, X. Shi, C. Wang, J. Q. Vuylsteke, A. Guo, X. Li, Z. | EBioMedicine | 2021 |
Circadian rhythm |
| Comparison of the Effects of Haloperidol and Dexmedetomidine on Delirium and Agitation in Patients with a Traumatic Brain Injury Admitted to the Intensive Care Unit | Soltani, F. Tabatabaei, S. Jannatmakan, F. Nasajian, N. Amiri, F. Darkhor, R. Moravej, M. | Anesth Pain Med | 2021 |
Delirium |
| Comparison of postoperative delirium within 24 hours between ketamine and propofol infusion during cardiopulmonary bypass machine: A randomized controlled trial | Siripoonyothai, S. Sindhvananda, W. | Ann Card Anaesth | 2021 |
*Cardiac surgery |
| Improving delirium detection in intensive care units: Multicomponent education and training program | Sinvani, L. Delle Site, C. Laumenede, T. Patel, V. Ardito, S. Ilyas, A. Hertz, C. Wolf-Klein, G. Pekmezaris, R. Hajizadeh, N. Thomas, L. | J Am Geriatr Soc | 2021 |
critical care nursing |
| Outcome, demography and resource utilization in ICU Patients with delirium and malignancy | Sieber, M. Rudiger, A. Schüpbach, R. Krüger, B. Schubert, M. Bettex, D. | Sci Rep | 2021 |
Medical research, Oncology, Delirium, ICU delirium, ICDSC, Malignancies |
| Prevalence of postoperative delirium with different combinations of intraoperative general anesthetic agents in patients undergoing cardiac surgery: A retrospective propensity-score-matched study | Shin, H. J. Choi, S. L. Na, H. S. | Medicine (Baltimore) | 2021 |
Aged |
| Is Comprehensive Geriatric Assessment Admission Avoidance Hospital at Home an Alternative to Hospital Admission for Older Persons? : A Randomized Trial | Shepperd, S. Butler, C. Cradduck-Bamford, A. Ellis, G. Gray, A. Hemsley, A. Khanna, P. Langhorne, P. Mort, S. Ramsay, S. Schiff, R. Stott, D. J. Wilkinson, A. Yu, L. M. Young, J. | Ann Intern Med | 2021 |
Aged |
| Delirium and abnormal autonomic nervous system response to head-up tilt testing | Shanahan, E. Ryan, S. Leahy, A. Sheehy, T. Costelloe, A. Roy, A. Galvin, R. Peters, C. Lyons, D. O'Connor, M. | Exp Gerontol | 2021 |
Aged, 80 and over |
| Understanding frailty among older people living in old age homes and the community in Nepal: A cross-sectional study | Shah, R. Carandang, R. R. Shibanuma, A. Ong, K. I. C. Kiriya, J. Jimba, M. | PLoS One | 2021 |
Activities of Daily Living |
| Death in delirious palliative-care patients occurs irrespective of age: A prospective, observational cohort study of 229 delirious palliative-care patients | Seiler, A. Blum, D. Hertler, C. Schettle, M. Zipser, C. M. Bode, L. Gehrke, S. Ernst, J. Schubert, M. von Känel, R. Boettger, S. | Palliat Support Care | 2021 |
Aged |
| Delirium Variability is Influenced by the Sound Environment (DEVISE Study): How Changes in the Intensive Care Unit soundscape affect delirium incidence | Sangari, A. Emhardt, E. A. Salas, B. Avery, A. Freundlich, R. E. Fabbri, D. Shotwell, M. S. Schlesinger, J. J. | J Med Syst | 2021 |
Critical Care |
| Delirium in Intensive Care Units: Perceptions of Physicians and Nurses | Salameh, B. Al Razeeni, D. M. Mansor, K. Abdallah, J. M. Ayed, A. Salem, H. | Crit Care Nurs Q | 2021 |
Critical Care |
| How to deal with the consent of adults with cognitive impairment involved in European geriatric living labs? | Sacco, G. Noublanche, F. Blazek, F. Hue, C. Carballido, L. Asfar, M. Allain, P. Annweiler, C. | Philos Ethics Humanit Med | 2021 |
Aged |
| Management of preoperative pain in elderly patients with moderate to severe cognitive deficits and hip fracture: a retrospective, monocentric study in an orthogeriatric unit | Ruel, M. Boussat, B. Boudissa, M. Garnier, V. Bioteau, C. Tonetti, J. Pailhe, R. Gavazzi, G. Drevet, S. | BMC Geriatr | 2021 |
Aged |
| Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial | Rozemeijer, S. de Grooth, H. J. Elbers, P. W. G. Girbes, A. R. J. den Uil, C. A. Dubois, E. A. Wils, E. J. Rettig, T. C. D. van Zanten, A. R. H. Vink, R. van den Bogaard, B. Bosman, R. J. Oudemans-van Straaten, H. M. de Man, A. M. E. | Trials | 2021 |
Ascorbic Acid |
| Synergistic Impact of Systolic Blood Pressure and Perfusion Status on Mortality in Acute Heart Failure | Rossello, X. Bueno, H. Gil, V. Jacob, J. Martín-Sánchez, F. J. Llorens, P. Herrero Puente, P. Alquézar-Arbé, A. Espinosa, B. Raposeiras-Roubín, S. Müller, C. E. Mebazaa, A. Maggioni, A. P. Pocock, S. Chioncel, O. Miró, Ò | Circ Heart Fail | 2021 |
Acute Disease |
| The Impact of Nursing Delirium Preventive Interventions in the ICU: A Multicenter Cluster-randomized Controlled Clinical Trial | Rood, P. J. T. Zegers, M. Ramnarain, D. Koopmans, M. Klarenbeek, T. Ewalds, E. van der Steen, M. S. Oldenbeuving, A. W. Kuiper, M. A. Teerenstra, S. Adang, E. van Loon, L. M. Wassenaar, A. Vermeulen, H. Pickkers, P. van den Boogaard, M. | Am J Respir Crit Care Med | 2021 |
Aged |
| Heart rate variability and delirium in acute non-cardioembolic stroke: a prospective, cross-sectional, cohort study | Rollo, E. Marotta, J. Callea, A. Brunetti, V. Vollono, C. Scala, I. Imperatori, C. Frisullo, G. Broccolini, A. Della Marca, G. | Neurol Sci | 2021 |
Autonomic |
| The training needs of Korean intensive care unit nurses regarding delirium | Roh, Y. S. | Intensive Crit Care Nurs | 2021 |
Clinical Competence |
| Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people-results from a nested, longitudinal cohort study | Richardson, S. J. Lawson, R. Davis, D. H. J. Stephan, B. C. M. Robinson, L. Matthews, F. E. Brayne, C. Barnes, L. E. Taylor, J. P. Parker, S. G. Allan, L. M. | Age Ageing | 2021 |
Aged |
| Recurrent delirium over 12 months predicts dementia: results of the Delirium and Cognitive Impact in Dementia (DECIDE) study | Richardson, S. J. Davis, D. H. J. Stephan, B. C. M. Robinson, L. Brayne, C. Barnes, L. E. Taylor, J. P. Parker, S. G. Allan, L. M. | Age Ageing | 2021 |
Cognition |
| Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated With Postoperative Delirium | Rhee, J. Kuznetsov, A. McKay, T. Lyons, M. Houstis, N. Mekkonen, J. Ethridge, B. Ibala, R. Hahm, E. Gitlin, J. Guseh, J. S. Kitchen, R. Rosenzweig, A. Shaefi, S. Flaczyk, A. Qu, J. Akeju, O. | Front Aging Neurosci | 2021 |
*il-6 |
| Comparison of Esophagectomy outcomes between a National Center, a National Audit Collaborative, and an International database using the Esophageal Complications Consensus Group (ECCG) standardized definitions | Reynolds, J. V. Donlon, N. Elliott, J. A. Donohoe, C. Ravi, N. Kuppusamy, M. K. Low, D. E. | Dis Esophagus | 2021 |
Aged |
| Health Profiles, Health Services Use, and Transition to Dementia in Inpatients With Late-Life Depression and Other Mental Illnesses | Reppermund, S. Heintze, T. Srasuebkul, P. Trollor, J. N. | J Am Med Dir Assoc | 2021 |
Aged |
| A Survey of Nurses' Perspectives on Delirium Screening in Older Adult Medical Inpatients With Limited English Proficiency | Reppas-Rindlisbacher, C. Panov, E. D. Cuperfain, A. B. Rawal, S. | J Gerontol Nurs | 2021 |
Aged |
| Post-hospital falls incidence and risk factors among older adults: a systematic review and meta-analysis | Qian, X. X. Chen, Z. Fong, D. Y. T. Ho, M. Chau, P. H. | Age Ageing | 2021 |
incidence |
| The prevalence of serotonin syndrome in an intensive care unit: A prospective observational study | Prakash, S. Rathore, C. Rana, K. | J Crit Care | 2021 |
Adult |
| Associations of subclinical heart failure and atrial fibrillation with mild cognitive impairment: a cross-sectional study in a subclinical heart failure screening programme | Potter, E. L. Ramkumar, S. Wright, L. Marwick, T. H. | BMJ Open | 2021 |
Aged |
| A One-Day Prospective National Observational Study on Sedation-Analgesia of Patients with Brain Injury in French Intensive Care Units: The SEDA-BIP-ICU (Sedation-Analgesia in Brain Injury Patient in ICU) Study | Poignant, S. Vigué, B. Balram, P. Biais, M. Carillon, R. Cottenceau, V. Dahyot-Fizelier, C. Degos, V. Geeraerts, T. Jeanjean, P. Vega, E. Lasocki, S. Espitalier, F. Laffon, M. | Neurocrit Care | 2021 |
Brain injury |
| Risk factors and adverse clinical outcomes of postoperative delirium in Thai elderly patients: A prospective cohort study | Pipanmekaporn, T. Punjasawadwong, Y. Wongpakaran, N. Wongpakaran, T. Suwannachai, K. Chittawatanarat, K. Mueankwan, S. | Perspect Psychiatr Care | 2021 |
Aged |
| Multifaceted intervention including Facebook-groups to improve guideline-adherence in ICU: A quasi-experimental interrupted time series study | Petosic, A. Småstuen, M. C. Beeckman, D. Flaatten, H. Sunde, K. Wøien, H. | Acta Anaesthesiol Scand | 2021 |
agitation/sedation |