What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Characteristics associated with effectiveness in postoperative delirium research: a systematic review of randomised controlled trials with meta-regression and meta-analysis
- Authors
- Meng, L. Zhao, X. Sun, Y. Cheng, S. Bao, L. Fang, K. Yu, Q. Zheng, Y. Wang, J. Luo, M. Gunderman, D. Vuckovic, N. Sidhu, A. S. Li, J. Li, G. Wolfe, J. W. Liu, Z. Adams, D. C.
- Year
- 2024
- Journal
- Br J Anaesth
- Abstract
BACKGROUND: Postoperative delirium remains prevalent despite extensive research through randomised trials aimed at reducing its incidence. Understanding trial characteristics associated with interventions’ effectiveness facilitates data interpretation. METHODS: Trial characteristics were extracted from eligible trials identified through two systematic literature searches. Multivariable meta-regression was used to investigate trial characteristics associated with effectiveness estimated using odds ratios. Meta-analysis was used to investigate pooled effectiveness. RESULTS: We identified 201 eligible trials. Compared with China, trials from the USA/Canada (ratio of odds ratio, 1.89; 95% confidence interval, 1.45-2.45) and Europe/Australia/New Zealand (1.67; 1.29-2.18) had an 89% and 67% higher odds ratio, respectively, suggesting reduced effectiveness. The effectiveness was enhanced when the incidence of postoperative delirium increased (0.85; 0.79-0.92, per 10% increase). Trials with concerns related to deviations from intended interventions reported increased effectiveness compared with those at low risk (0.69; 0.53-0.90). Compared with usual care, certain interventions appeared to have reduced the incidence of postoperative delirium in low-risk trials with low-to-moderate certainty of evidence. However, these findings should be considered inconclusive because of challenges in grouping heterogeneous interventions, the limited number of eligible trials, the prevalence of small-scale studies, and potential publication bias. CONCLUSIONS: The effectiveness of postoperative delirium trials varied based on the region of trial origin, the incidence of delirium, and the risk of bias. The limitations caution against drawing definitive conclusions from different bodies of evidence. These findings highlight the imperative need to improve the quality of research on a global scale. SYSTEMATIC REVIEW PROTOCOL: PROSPERO (CRD42023413984).
- PMID
PMID: 38969535
- Keywords
Humans
*Randomized Controlled Trials as Topic
*Postoperative Complications/epidemiology/prevention & control
Delirium/prevention & control/epidemiology
Emergence Delirium/prevention & control/epidemiology
certainty of the evidence
intervention effectiveness
postoperative delirium
randomised controlled trial
trial characteristics
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Impact of Delirium and Its Motor Subtypes on Stroke Outcomes | Fialho Silva, I. T. Assis Lopes, P. Timotio Almeida, T. Ramos, S. C. Caliman Fontes, A. T. Guimarães Silva, D. Martins Soares, C. Oliveira Carneiro, L. Souza, I. F. B. Ferreira Abreu, F. Nascimento Silva, G. Mascarenhas de Souza, L. Brito Pinheiro, T. de | Stroke | 2021 |
cognition |
| The experience of delirium in palliative care settings for patients, family, clinicians and volunteers: A qualitative systematic review and thematic synthesis | Featherstone, I. Hosie, A. Siddiqi, N. Grassau, P. Bush, S. H. Taylor, J. Sheldon, T. Johnson, M. J. | Palliat Med | 2021 |
Delirium |
| The association of post-operative delirium with patient-reported outcomes and mortality after lung transplantation | DeBolt, C. L. Gao, Y. Sutter, N. Soong, A. Leard, L. Jeffrey, G. Kleinhenz, M. E. Calabrese, D. Greenland, J. Venado, A. Hays, S. R. Shah, R. Kukreja, J. Trinh, B. Kolaitis, N. A. Douglas, V. Diamond, J. M. Smith, P. Singer, J. | Clin Transplant | 2021 |
Critical care medicine |
| Does rocking motion calm delirious patients in ICU? A multicentre randomised clinical trial protocol (RockingICU) | Collet, M. O. Nielsen, G. M. Bang, B. Laerkner, E. Fischer, S. Langvad, A. Thorn, L. Lange, T. Egerod, I. | Acta Anaesthesiol Scand | 2021 |
delirium |
| Do specific delirium aetiologies have different associations with death? A longitudinal cohort of hospitalised patients | Chalmers, L. A. Searle, S. D. Whitby, J. Tsui, A. Davis, D. | Eur Geriatr Med | 2021 |
Aetiology |
| Development and External Validation of a Delirium Prediction Model for Hospitalized Patients With Coronavirus Disease 2019 | Castro, V. M. Sacks, C. A. Perlis, R. H. McCoy, T. H. | J Acad Consult Liaison Psychiatry | 2021 |
Covid-19 |
| Incidence and risk factors of delirium in surgical intensive care unit | Ali, M. A. Hashmi, M. Ahmed, W. Raza, S. A. Khan, M. F. Salim, B. | Trauma Surg Acute Care Open | 2021 |
brain |
| Economic Impact of Poststroke Delirium and Associated Risk Factors: Findings From a Prospective Cohort Study | Zipser, C. M. Deuel, J. W. Held, J. P. O. Ernst, J. Schubert, M. Weller, M. Luft, A. R. von Känel, R. Boettger, S. | Stroke | 2021 |
costs |
| Development and validation of a delirium risk assessment tool in older patients admitted to the Emergency Department Observation Unit | Zucchelli, A. Apuzzo, R. Paolillo, C. Prestipino, V. De Bianchi, S. Romanelli, G. Padovani, A. Marengoni, A. Bellelli, G. | Aging Clin Exp Res | 2021 |
Delirium |
| Differences in efficacy and safety of midazolam vs. dexmedetomidine in critically ill patients: A meta-analysis of randomized controlled trial | Zhou, W. J. Liu, M. Fan, X. P. | Exp Ther Med | 2021 |
critically ill |
| Risk factors of postoperative delirium after liver transplantation: a systematic review and meta-analysis | Zhou, J. Xu, X. Liang, Y. Zhang, X. Tu, H. Chu, H. | Minerva Anestesiol | 2021 | |
| Derivation and validation of a novel comorbidity-based delirium risk index to predict postoperative delirium using national administrative healthcare database | Zhong, X. Lin, J. Y. Li, L. Barrett, A. M. Poeran, J. Mazumdar, M. | Health Serv Res | 2021 |
Lasso |
| The Association Between Frailty and Delirium Among Hospitalized Patients: An Updated Meta-Analysis | Zhang, X. M. Jiao, J. Xie, X. H. Wu, X. J. | J Am Med Dir Assoc | 2021 |
Frailty |
| Effectiveness of Bundle Interventions on ICU Delirium: A Meta-Analysis | Zhang, S. Han, Y. Xiao, Q. Li, H. Wu, Y. | Crit Care Med | 2021 | |
| Development and validation of a predictive score for ICU delirium in critically ill patients | Zhang, H. Yuan, J. Chen, Q. Cao, Y. Wang, Z. Lu, W. Bao, J. | BMC Anesthesiol | 2021 |
Delirium |
| Comparison of the '4-item assessment test' and 'nursing delirium screening scale' delirium screening tools on nonintensive care unit wards: A prospective mixed-method approach | Zastrow, I. Tohsche, P. Loewen, T. Vogt, B. Feige, M. Behnke, M. Wolff, A. Kiefmann, R. Olotu, C. | Eur J Anaesthesiol | 2021 | |
| Effects of general versus regional anaesthesia on circadian melatonin rhythm and its association with postoperative delirium in elderly patients undergoing hip fracture surgery: study protocol for a prospective cohort clinical trial | Yuan, Y. Song, Y. Wang, G. Jia, Y. Zhou, Y. Mi, X. Jia, X. Wang, X. Liu, C. Li, Y. Shi, C. Han, Y. Guo, X. Zhang, W. Li, Z. | BMJ Open | 2021 |
Aged |
| Association Between Dexamethasone and Delirium in Critically Ill Patients: A Retrospective Cohort Study of a Large Clinical Database | Wu, Z. Li, H. Liao, K. Wang, Y. | J Surg Res | 2021 |
Delirium |
| Perioperative risk factors for recovery room delirium after elective non-cardiovascular surgery under general anaesthesia | Wu, J. Gao, S. Zhang, S. Yu, Y. Liu, S. Zhang, Z. Mei, W. | Perioper Med (Lond) | 2021 |
Delirium |
| Management of delirium within intraoperative settings for older adults with hip fracture: a scoping review | White, L. B. Coyne, E. Grealish, L. | J Clin Nurs | 2021 |
Anaesthesia |
| Delirium screening tools validated in the context of palliative care: A systematic review | Watt, C. L. Scott, M. Webber, C. Sikora, L. Bush, S. H. Kabir, M. Boland, J. W. Woodhouse, R. Sands, M. B. Lawlor, P. G. | Palliat Med | 2021 |
Adult |
| The Relationship of Postoperative Delirium and Unplanned Perioperative Hypothermia in Surgical Patients | Wagner, D. Hooper, V. Bankieris, K. Johnson, A. | J Perianesth Nurs | 2021 |
noncardiac surgery |
| Proteome-Wide Analysis using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery | Vasunilashorn, S. M. Dillon, S. T. Chan, N. Y. Fong, T. G. Joseph, M. Tripp, B. Xie, Z. Ngo, L. H. Lee, C. G. Elias, J. A. Otu, H. H. Inouye, S. Marcantonio, E. R. Libermann, T. A. | J Gerontol A Biol Sci Med Sci | 2021 |
inflammation |
| Delirium in your house: a survey during General Practitioner-programmed home visits | Tremolizzo, L. Bargossi, L. Storti, B. Ferrarese, C. Bellelli, G. Appollonio, I. | Aging Clin Exp Res | 2021 |
4at |
| Dexmedetomidine for hyperactive delirium at the end of life: An open-label single arm pilot study with dose escalation in adult patients admitted to an inpatient palliative care unit | Thomas, B. Lo, W. A. Nangati, Z. Barclay, G. | Palliat Med | 2021 |
Adult |
| Significant decrease in delirium referrals after changing hypnotic from benzodiazepine to suvorexant | Tachibana, M. Inada, T. Ichida, M. Kojima, S. Arai, T. Naito, K. Ozaki, N. | Psychogeriatrics | 2021 |
Aged |
| Haloperidol, clonidine and resolution of delirium in critically ill patients: a prospective cohort study | Smit, L. Dijkstra-Kersten, S. M. A. Zaal, I. J. van der Jagt, M. Slooter, A. J. C. | Intensive Care Med | 2021 |
Clonidine/therapeutic use |
| Acute-onset delirium in intensive care COVID patients: association of imperfect brain repair with foodborne micro-pollutants | Schneider, F. Agin, A. Baldacini, M. Maurer, L. Schenck, M. Alemann, M. Solis, M. Helms, J. Villette, C. Artzner, T. Kremer, S. Heintz, D. | Eur J Neurol | 2021 |
Covid |
| Delirium in acute stroke: A prospective, cross-sectional, cohort study | Rollo, E. Callea, A. Brunetti, V. Vollono, C. Marotta, J. Imperatori, C. Frisullo, G. Broccolini, A. Della Marca, G. | Eur J Neurol | 2021 |
Cam-icu |
| Preoperative Cognitive Impairment and the Prevalence of Postoperative Delirium in Elderly Cancer Patients-A Prospective Observational Study | Ristescu, A. I. Pintilie, G. Moscalu, M. Rusu, D. Grigoras, I. | Diagnostics (Basel) | 2021 |
Mini-Cog test |
| Delirium in Patients with SARS-CoV-2 Infection: A Multicenter Study | Rebora, P. Rozzini, R. Bianchetti, A. Blangiardo, P. Marchegiani, A. Piazzoli, A. Mazzeo, F. Cesaroni, G. Chizzoli, A. Guerini, F. Bonfanti, P. Morandi, A. Faraci, B. Gentile, S. Bna, C. Savelli, G. Citerio, G. Valsecchi, M. G. Mazzola, P. Bellelli, G. | J Am Geriatr Soc | 2021 |
Aged |
| Machine Learning to Develop and Internally Validate a Predictive Model for Post-operative Delirium in a Prospective, Observational Clinical Cohort Study of Older Surgical Patients | Racine, A. M. Tommet, D. D'Aquila, M. L. Fong, T. G. Gou, Y. Tabloski, P. A. Metzger, E. D. Hshieh, T. T. Schmitt, E. M. Vasunilashorn, S. M. Kunze, L. Vlassakov, K. Abdeen, A. Lange, J. Earp, B. Dickerson, B. C. Marcantonio, E. R. Steingrimsson, J. Travi | J Gen Intern Med | 2021 |
Aged |
| Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older UK Biobank Participants | Pilling, L. C. Jones, L. C. Masoli, J. A. H. Delgado, J. Atkins, J. L. Bowden, J. Fortinsky, R. H. Kuchel, G. A. Melzer, D. | J Am Geriatr Soc | 2021 |
biomarker |
| Delirium in older adults is associated with development of new dementia: a systematic review and meta-analysis | Pereira, J. V. Aung Thein, M. Z. Nitchingham, A. Caplan, G. A. | Int J Geriatr Psychiatry | 2021 |
delirium |
| Mortality and Medical Complications of Subtrochanteric Fracture Fixation | Panteli, M. Giannoudi, M. P. Lodge, C. J. West, R. M. Pountos, I. Giannoudis, P. V. | J Clin Med | 2021 |
complications |
| Predicting Delirium Risk Using an Automated Mayo Delirium Prediction Tool: Development and Validation of a Risk-Stratification Model | Pagali, S. R. Miller, D. Fischer, K. Schroeder, D. Egger, N. Manning, D. M. Lapid, M. I. Pignolo, R. J. Burton, M. C. | Mayo Clin Proc | 2021 |
Aged |
| Effectiveness of Quetiapine as a Sedative Adjunct in Mechanically Ventilated Adults Without Delirium | Ohman, K. L. Schultheis, J. M. Kram, S. J. Cox, C. E. Gilstrap, D. L. Yang, Z. Kram, B. L. | Ann Pharmacother | 2021 |
Adjuvants, Pharmaceutic/administration & dosage/ therapeutic use |
| Development of a postoperative delirium risk scoring tool using data from the Australian and New Zealand Hip Fracture Registry: an analysis of 6672 patients 2017-2018 | Oberai, T. Oosterhoff, J. H. F. Woodman, R. Doornberg, J. N. Kerkhoffs, G. Jaarsma, R. | Arch Gerontol Geriatr | 2021 |
Aged, 80 and over |
| Does implementation of a tailored intervention increase adherence to a National Safety and Quality Standard? A study to improve delirium care | Oberai, T. Laver, K. Woodman, R. Crotty, M. Kerkhoffs, G. Jaarsma, R. | Int J Qual Health Care | 2021 |
elderly |
| Delirium in Burn Patients: Developing a Mobile Application for Assessment and Diagnosis | Mohseni Moallem Kolaei, N. Ayatollahi, H. Elyasi, F. | J Burn Care Res | 2021 | |
| Combination of delirium and coma predicts psychiatric symptoms at twelve months in critically ill patients: A longitudinal cohort study | Miyamoto, K. Shibata, M. Shima, N. Nakashima, T. Kida, M. Matsumoto, H. Oka, N. Yazaki, A. Uchigaki, A. Takemoto, A. Kato, S. | J Crit Care | 2021 |
Activity of daily living disability |
| Implementation of the Family HELP Protocol: A Feasibility Project for a West Texas ICU | McClay, R. | Healthcare (Basel) | 2021 |
Icu |
| Prevention and Management of Delirium in the Intensive Care Unit | Mart, M. F. Williams Roberson, S. Salas, B. Pandharipande, P. P. Ely, E. W. | Semin Respir Crit Care Med | 2021 | |
| Haloperidol for preventing delirium in ICU patients: a systematic review and meta-analysis | Marra, A. Vargas, M. Buonanno, P. Iacovazzo, C. Kotfis, K. Servillo, G. | Eur Rev Med Pharmacol Sci | 2021 |
Delirium |
| Delirium in trauma patients: a 1-year prospective cohort study of 2026 patients | Marquetand, J. Gehrke, S. Bode, L. Fuchs, S. Hildenbrand, F. Ernst, J. von Känel, R. Boettger, S. | Eur J Trauma Emerg Surg | 2021 |
Delirium |
| Subsyndromal Delirium in Cardiac Surgery Patients: Risk Factors and Outcomes of the Different Trajectories | Mailhot, T. Cossette, S. Maheu-Cadotte, M. A. Fontaine, G. Denault, A. Y. | J Cardiovasc Nurs | 2021 | |
| Low-Dose Trazodone for Delirium in Patients with Cancer Who Received Specialist Palliative Care: A Multicenter Prospective Study | Maeda, I. Inoue, S. Uemura, K. Tanimukai, H. Hatano, Y. Yokomichi, N. Amano, K. Tagami, K. Yoshiuchi, K. Ogawa, A. Iwase, S | J Palliat Med | 2021 |
cancer |
| Preoperative anxiety predicted the incidence of postoperative delirium in patients undergoing total hip arthroplasty: a prospective cohort study | Ma, J. Li, C. Zhang, W. Zhou, L. Shu, S. Wang, S. Wang, D. Chai, X. | BMC Anesthesiol | 2021 |
Anxiety |
| Perioperative Dexmedetomidine Supplement Decreases Delirium Incidence After Adult Cardiac Surgery: A Randomized, Double-Blind, Controlled Study | Likhvantsev, V. V. Landoni, G. Grebenchikov, O. A. Ovezov, A. M. Skripkin, Y. V. Lembo, R. Gaevskiy, D. I. Tereshina, A. A. Yavorovskiy, A. G. | J Cardiothorac Vasc Anesth | 2021 |
Adult |
| An observational study of hypoactive delirium in the post-anesthesia recovery unit of a pediatric hospital | Lee-Archer, P. F. von Ungern-Sternberg, B. S. Reade, M. C. Law, K. C. Long, D. | Paediatr Anaesth | 2021 |
emergence delirium |
| A prospective observational cohort pilot study of the association between midazolam use and delirium in elderly endoscopy patients | Lee, D. Petersen, F. Wu, M. Chapman, G. Hayman, M. Tomkins, K. Fernando, J. | BMC Anesthesiol | 2021 |
Anaesthesia |
| Discharge from hospital with newly administered antipsychotics after intensive care unit delirium - Incidence and contributing factors | Lambert, J. Vermassen, J. Fierens, J. Peperstraete, H. Petrovic, M. Colpaert, K. | J Crit Care | 2021 |
Antipsychotics |
| Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis | Hughes, C. G. Mailloux, P. T. Devlin, J. W. Swan, J. T. Sanders, R. D. Anzueto, A. Jackson, J. C. Hoskins, A. S. Pun, B. T. Orun, O. M. Raman, R. Stollings, J. L. Kiehl, A. L. Duprey, M. S. Bui, L. N. O'Neal, H. R., Jr. Snyder, A. Gropper, M. A. Guntupall | N Engl J Med | 2021 |
Adult |
| Repeated Preoperative Intranasal Administration of Insulin Decreases the Incidence of Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Radical Gastrointestinal Surgery: A Randomized, Placebo-Controlled, Double-Blinded Clinical Study | Huang, Q. Li, Q. Qin, F. Yuan, L. Lu, Z. Nie, H. Gong, G. | Am J Geriatr Psychiatry | 2021 |
Postoperative delirium |
| The diagnostic threshold of Cornell assessment of pediatric delirium in detection of postoperative delirium in pediatric surgical patients | Hong, H. Guo, C. Liu, Z. H. Wang, B. J. Zhou, S. Z. Mu, D. L. Wang, D. X. | BMC Pediatr | 2021 |
Child |
| Ketamine vs. haloperidol for prevention of cognitive dysfunction and postoperative delirium: A phase IV multicentre randomised placebo-controlled double-blind clinical trial | Hollinger, A. Rüst, C. A. Riegger, H. Gysi, B. Tran, F. Brügger, J. Huber, J. Toft, K. Surbeck, M. Schmid, H. R. Rentsch, K. Steiner, L. Siegemund, M. | J Clin Anesth | 2021 |
Adult |
| Delirium care knowledge in critical care nurses: A multiple-choice question-based quiz | Ho, M. H. Traynor, V. Chen, K. H. Montayre, J. Lin, Y. K. Chang, H. R. | Nurs Crit Care | 2021 |
critical care nursing |
| Comparison of hospital course and outcome in hospital-acquired vs pre-existing delirium | Guillory, J. Fitz-Gerald, C. Banik, A. Sterwald, C. Ashiofu, E. Knox, E. Muyco, M. A. Verlage, M. Abdali, A. O'Malley, P. W. Rezai, A. Bush, P. Brown, E. S. North, C. S. | Ann Clin Psychiatry | 2021 | |
| Dexmedetomidine reduces postoperative cognitive and behavioral dysfunction in adults submitted to general anesthesia for non-cardiac surgery: meta-analysis of randomized clinical trials | Govêia, C. S. Miranda, D. B. Oliveira, L. V. B. Praxedes, F. B. Moreira, L. G. Guimarães, G. M. N. | Braz J Anesthesiol | 2021 |
Delirium |
| An exploration of the reliability and usability of two delirium screening tools in an Australian intensive care unit: A pilot study | Ewers, R. Bloomer, M. J. Hutchinson, A. | Intensive Crit Care Nurs | 2021 |
Confusion assessment methods -ICU |
| Haloperidol and Quetiapine for the Treatment of ICU-Associated Delirium in a Tertiary Pediatric ICU: A Propensity Score-Matched Cohort Study | Cronin, M. T. Di Gennaro, J. L. Watson, R. S. Dervan, L. A. | Paediatr Drugs | 2021 |
Antipsychotic Agents/therapeutic use |
| Post-operative delirium in older hip fracture patients: a new onset or was it already there? | Costa-Martins, I. Carreteiro, J. Santos, A. Costa-Martins, M. Artilheiro, V. Duque, S. Campos, L. Chedas, M. | Eur Geriatr Med | 2021 |
Cognitive assessment |
| The Use of Tablet Computers to Reduce Preoperative Anxiety in Children Before Anesthesia: A Randomized Controlled Study | Clausen, N. G. Madsen, D. Rosenkilde, C. Hasfeldt-Hansen, D. Larsen, L. G. Hansen, T. G. | J Perianesth Nurs | 2021 |
emergence delirium |
| A gap existed between physicians' perceptions and performance of pain, agitation-sedation and delirium assessments in Chinese intensive care units | Chen, K. Yang, Y. L. Li, H. L. Xiao, D. Wang, Y. Zhang, L. Zhou, J. X. | BMC Anesthesiol | 2021 |
Analgesia |
| Association of Depressive Symptoms With Postoperative Delirium and CSF Biomarkers for Alzheimer's Disease Among Hip Fracture Patients | Chan, C. K. Sieber, F. E. Blennow, K. Inouye, S. K. Kahn, G. Leoutsakos, J. S. Marcantonio, E. R. Neufeld, K. J. Rosenberg, P. B. Wang, N. Y. Zetterberg, H. Lyketsos, C. G. Oh, E. S. | Am J Geriatr Psychiatry | 2021 |
Alzheimer’s disease |
| Delirium as a predictor of mortality and disability among hospitalized patients in Zambia | Banerdt, J. K. Mateyo, K. Wang, L. Lindsell, C. J. Riviello, E. D. Saylor, D. Heimburger, D. C. Ely, E. W. | PLoS One | 2021 | |
| Incidence and Risk Factors of Emergence Delirium after Anesthesia in Elderly Patients at a Postanesthesia Care Unit in Ethiopia: Prospective Observational Study | Assefa, M. T. Chekol, W. B. Melesse, D. Y. Nigatu, Y. A. | Patient Relat Outcome Meas | 2021 |
delirium |
| Impact of SARS-CoV-2 Infection on Cognitive Function: A Systematic Review | Alnefeesi, Y. Siegel, A. Lui, L. M. W. Teopiz, K. M. Ho, R. C. M. Lee, Y. Nasri, F. Gill, H. Lin, K. Cao, B. Rosenblat, J. D. McIntyre, R. S. | Front Psychiatry | 2021 |
Covid-19 |
| Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study | Zhou, J. Liu, C. Sun, Y. Huang, W. Ye, K. | Brain Behav Immun | 2021 |
Adult |
| Probable delirium is a presenting symptom of COVID-19 in frail, older adults: a cohort study of 322 hospitalised and 535 community-based older adults | Zazzara, M. B. Penfold, R. S. Roberts, A. L. Lee, K. A. Dooley, H. Sudre, C. H. Welch, C. Bowyer, R. C. E. Visconti, A. Mangino, M. Freidin, M. B. El-Sayed Moustafa, J. S. Small, K. S. Murray, B. Modat, M. Graham, M. S. Wolf, J. Ourselin, S. Martin, F. C. | Age Ageing | 2021 |
Aged |
| Association between intensive care unit delirium and delusional memory after critical care in mechanically ventilated patients | Yoshino, Y. Unoki, T. Sakuramoto, H. Ouchi, A. Hoshino, H. Matsuishi, Y. Mizutani, T. | Nurs Open | 2021 |
delirium |
| Delirium screening for patients in the intensive care unit: A prospective validation study of the iCAM-ICU by nurse researchers and bedside nurses in routine practice | Yang, F. Ji, M. Wu, Y. Feng, Y. Li, J. Ren, D. Ely, E. W. | Int J Nurs Stud | 2021 |
Confusion |
| Six-Minute Walk Test Predicts Postoperative Delirium After Transcatheter Aortic Valve Replacement | Yamashita, A. Suzuki, S. Otsuka, T. Matsuda, H. Ando, H. Sugimura, K. Maekawa, E. Meguro, K. Ako, J. Okamoto, H. | J Cardiothorac Vasc Anesth | 2021 |
Clinical Frailty Scale |
| Topological data analysis (TDA) enhances bispectral EEG (BSEEG) algorithm for detection of delirium | Yamanashi, T. Kajitani, M. Iwata, M. Crutchley, K. J. Marra, P. Malicoat, J. R. Williams, J. C. Leyden, L. R. Long, H. Lo, D. Schacher, C. J. Hiraoka, K. Tsunoda, T. Kobayashi, K. Ikai, Y. Kaneko, K. Umeda, Y. Kadooka, Y. Shinozaki, G. | Sci Rep | 2021 | |
| New Cutoff Scores for Delirium Screening Tools to Predict Patient Mortality | Yamanashi, T. Iwata, M. Crutchley, K. J. Sullivan, E. J. Malicoat, J. R. Anderson, Z. M. Marra, P. S. Chang, G. Kaneko, K. Shinozaki, E. Lee, S. Shinozaki, G. | J Am Geriatr Soc | 2021 |
Cam-icu |
| Intraoperative dexmedetomidine for prevention of postoperative delirium in elderly patients with mild cognitive impairment | Xin, X. Chen, J. Hua, W. Wang, H. | Int J Geriatr Psychiatry | 2021 |
Aged |
| The risk factors for postoperative delirium in adult patients after hip fracture surgery: a systematic review and meta-analysis | Wu, J. Yin, Y. Jin, M. Li, B. | Int J Geriatr Psychiatry | 2021 |
Blood Transfusion |
| Preoperative Delirium Nursing Model Initiatives to Determine the Incidence of Postoperative Delirium Among Elderly Orthopaedic Patients | Wu, H. Kapur, A. Gibson, B. Bubb, K. Alrawashdeh, M. Cipkala-Gaffin, J. | Orthop Nurs | 2021 | |
| Challenges of Delirium Management in Patients with Traumatic Brain Injury: From Pathophysiology to Clinical Practice | Williams Roberson, S. Patel, M. B. Dabrowski, W. Ely, E. W. Pakulski, C. Kotfis, K. | Curr Neuropharmacol | 2021 |
barbiturates |
| A Systematic Review of Delirium Biomarkers and Their Alignment with the NIA-AA Research Framework | Wang, S. Lindroth, H. Chan, C. Greene, R. Serrano-Andrews, P. Khan, S. Rios, G. Jabbari, S. Lim, J. Saykin, A. J. Khan, B. | J Am Geriatr Soc | 2021 |
Alzheimerʼs disease |
| Development and validation of the Terminal Delirium-Related Distress Scale to assess irreversible terminal delirium | Uchida, M. Akechi, T. Morita, T. Shima, Y. Igarashi, N. Miyashita, M. | Palliat Support Care | 2021 |
Cancer |
| Targeted metabolomics analysis of postoperative delirium | Tripp, B. A. Dillon, S. T. Yuan, M. Asara, J. M. Vasunilashorn, S. M. Fong, T. G. Metzger, E. D. Inouye, S. K. Xie, Z. Ngo, L. H. Marcantonio, E. R. Libermann, T. A. Otu, H. H. | Sci Rep | 2021 | |
| Hospitalized older adult: predictors of functional decline | Tavares, J. P. A. Nunes, Lanv Grácio, J. C. G. | Rev Lat Am Enfermagem | 2021 |
Activities of Daily Living |
| Postoperative delirium in patients undergoing tumor resection with reconstructive surgery for oral cancer | Takahashi, N. Hiraki, A. Kawahara, K. Nagata, M. Yoshida, R. Matsuoka, Y. Tanaka, T. Obayashi, Y. Sakata, J. Nakashima, H. Arita, H. Shinohara, M. Nakayama, H. | Mol Clin Oncol | 2021 |
early postoperative ambulation |
| Prevalence of ICU Delirium in Postoperative Pediatric Cardiac Surgery Patients | Staveski, S. L. Pickler, R. H. Khoury, P. R. Ollberding, N. J. Donnellan, A. L. Mauney, J. A. Lincoln, P. A. Baird, J. D. Gilliland, F. L. Merritt, A. D. Presnell, L. B. Lanese, A. R. Lisanti, A. J. Large, B. J. Fineman, L. D. Gibson, K. H. Mohler, L. A. | Pediatr Crit Care Med | 2021 |
Adolescent |
| Physostigmine for prevention of postoperative delirium and long-term cognitive dysfunction in liver surgery: A double-blinded randomised controlled trial | Spies, C. D. Knaak, C. Mertens, M. Brockhaus, W. R. Shadenok, A. Wiebach, J. Kunzmann, K. Feldheiser, A. Pratschke, J. Müller, O. Kipping, V. Fabian, M. Abels, W. Borchers, F. Akyüz, L. Ely, E. W. Wernecke, K. D. Menon, D. K. Piper, S. K. | Eur J Anaesthesiol | 2021 | |
| Intraoperative clonidine to prevent postoperative emergence delirium following sevoflurane anesthesia in pediatric patients: a randomized clinical trial | Sousa-Júnior, F. A. Souza, A. S. R. Lima, L. C. Santos Í, G. M. Menezes, L. A. P. Ratis, Papl Couceiro, T. C. M. | Braz J Anesthesiol | 2021 |
Anesthesia |
| Training hospital inpatient nursing to know (THINK) delirium: A nursing educational program | Solberg, L. M. Campbell, C. S. Jones, K. Vaughn, I. Suryadevara, U. Fernandez, C. Shorr, R. | Geriatr Nurs | 2021 |
Delirium |
| Delirium is associated with an increased morbidity and in-hospital mortality in cancer patients: Results from a prospective cohort study | Seiler, A. Blum, D. Deuel, J. W. Hertler, C. Schettle, M. Zipser, C. M. Ernst, J. Schubert, M. von Känel, R. Boettger, S. | Palliat Support Care | 2021 |
Cancer patients |
| Delirium Triage Screen/Brief Confusion Assessment Method in Adult Orthopaedic and Hematological Patients: A Validation Study | Sederstrom, J. R. Aliory, C. D. Hanneman, E. M. Buras, M. R. | Orthop Nurs | 2021 | |
| "SQiD, the Single Question in Delirium; can a single question help clinicians to detect delirium in hospitalised cancer patients?" running heading Single Question in Delirium" (Bcan-D-20-01665) | Sands, M. B. Sharma, S. Carpenter, L. Hartshorn, A. Lee, J. T. Lujic, S. Congdon, M. E. Buchanan, A. M. Agar, M. Vardy, J. L. | BMC Cancer | 2021 |
Cancer |
| Factors Impacting Early Mobilization Following Hip Fracture: An Observational Study | Said, C. M. Delahunt, M. Ciavarella, V. Al Maliki, D. Boys, A. M. Vogrin, S. Berney, S. | J Geriatr Phys Ther | 2021 | |
| Risk factors of postoperative delirium in the knee and hip replacement patients: a systematic review and meta-analysis | Rong, X. Ding, Z. C. Yu, H. D. Yao, S. Y. Zhou, Z. K. | J Orthop Surg Res | 2021 |
Hip replacement |
| Characteristics of Younger and Older Adults with Hospital-Acquired Delirium: a Claims Data Study Spanning 14 years | Rohatgi, N. Weng, Y. Ahuja, N. Lansberg, M. G. | J Gen Intern Med | 2021 |
Aged |
| Factors Associated with Hospital-Acquired Delirium in Patients 18-65 Years Old | Rohatgi, N. Weng, Y. Ahuja, N. Lansberg, M. G. | J Gen Intern Med | 2021 |
Adolescent |
| Implementation of a multicomponent intervention sign to reduce delirium in orthopaedic inpatients (MIND-ORIENT): a quality improvement project | Reppas-Rindlisbacher, C. Siddhpuria, S. Wong, E. K. Lee, J. Y. Gabor, C. Curkovic, A. Khalili, Y. Mavrak, C. De Freitas, S. Eshak, K. Patterson, C. | BMJ Open Qual | 2021 |
evidence-based practice |
| Anticholinergic Burden Does Not Influence Delirium Subtype or the Delirium-Mortality Association in Hospitalized Older Adults: Results from a Prospective Cohort Study | Rawle, M. J. McCue, L. Sampson, E. L. Davis, D. Vickerstaff, V. | Drugs Aging | 2021 | |
| Incidence and Risk Factors of Delirium in the Intensive Care Unit: A Prospective Cohort | Rahimi-Bashar, F. Abolhasani, G. Manouchehrian, N. Jiryaee, N. Vahedian-Azimi, A. Sahebkar, A. | Biomed Res Int | 2021 |
Adult |
| Implementing Delirium Prevention in the Era of COVID-19 | Radhakrishnan, N. S. Mufti, M. Ortiz, D. Maye, S. T. Melara, J. Lim, D. Rosenberg, E. I. Price, C. C. | J Alzheimers Dis | 2021 |
Aged |
| Prevalence and risk factors of delirium in psychogeriatric outpatients | Quispel-Aggenbach, D. W. P. Schep-de Ruiter, E. P. R. van Bergen, W. Bolling, J. R. Zuidema, S. U. Luijendijk, H. J. | Int J Geriatr Psychiatry | 2021 |
Aged |