What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Case-control study on the interplay between immunoparalysis and delirium after cardiac surgery | CheheiliSobbi, S. Peters van Ton, A. M. Wesselink, E. M. Looije, M. F. Gerretsen, J. Morshuis, W. J. Slooter, A. J. C. Abdo, W. F. Pickkers, P. van den Boogaard, M. | J Cardiothorac Surg | 2021 |
*Cardiac Surgical Procedures/adverse effects |
| Diagnostic accuracy of the "4 A's Test" delirium screening tool for the postoperative cardiac surgery ward | Chang, Y. Ragheb, S. M. Oravec, N. Kent, D. Nugent, K. Cornick, A. Hiebert, B. Rudolph, J. L. MacLullich, A. M. J. Arora, R. C. | J Thorac Cardiovasc Surg | 2021 |
4at |
| Meta-analysis of ICU Delirium Biomarkers and Their Alignment With the NIA-AA Research Framework | Chan, C. K. Song, Y. Greene, R. Lindroth, H. Khan, S. Rios, G. Khan, B. Wang, S | Am J Crit Care | 2021 |
Alzheimer Disease |
| Sedation strategy and ICU delirium: a multicentre, population-based propensity score-matched cohort study | Casault, C. Soo, A. Lee, C. H. Couillard, P. Niven, D. Stelfox, T. Fiest, K. | BMJ Open | 2021 |
Adult |
| Health outcomes after the implementation of multidisciplinary clinical guidelines for the care of hip fractures | Casanova Querol, T. Santiago Bautista, J. M. Lafuente Salinas, M. Güell Farré, E. Girós Torres, J. Martín-Baranera, M. Miralles Basseda, R. | Rev Clin Esp (Barc) | 2021 |
Atención continuada |
| Pharmacological and non-pharmacological interventions to prevent delirium in critically ill patients: a systematic review and network meta-analysis | Burry, L. D. Cheng, W. Williamson, D. R. Adhikari, N. K. Egerod, I. Kanji, S. Martin, C. M. Hutton, B. Rose, L. | Intensive Care Med | 2021 |
Adult |
| Dexmedetomidine for Facilitating Mechanical Ventilation Extubation in Difficult-to-Wean ICU Patients: Systematic Review and Meta-Analysis of Clinical Trials | Buckley, M. S. Smithburger, P. L. Wong, A. Fraser, G. L. Reade, M. C. Klein-Fedyshin, M. Ardiles, T. Kane-Gill, S. L. | J Intensive Care Med | 2021 |
Adult |
| Risk factors for postoperative delirium: An umbrella review of systematic reviews | Bramley, P. McArthur, K. Blayney, A. McCullagh, I. | Int J Surg | 2021 |
*Cognitive Dysfunction |
| Inadequate emergence after anesthesia for elective cancer surgery: a single-center cohort study | Braga, A. Abelha, F. | Braz J Anesthesiol | 2021 |
Cancer surgeries |
| Asthma and delirium episodes during hospitalization | Bozek, A. Fiolka, R. Zajac, M. | Aging Med (Milton) | 2021 |
asthma |
| A pragmatic assessment of proton pump inhibitors vs. histamine type 2 receptor antagonists on clinically important gastrointestinal bleeding and mortality when used for stress ulcer prophylaxis in the ICU | Boyd, C. Hassig, T. MacLaren, R. | Pharmacotherapy | 2021 |
critical illness |
| Brain Network Dysfunction in Poststroke Delirium and Spatial Neglect: An fMRI Study | Boukrina, O. Kowalczyk, M. Koush, Y. Kong, Y. Barrett, A. M. | Stroke | 2021 |
MRI, functional |
| Preventing Delirium and Promoting Long-Term Brain Health: A Clinical Trial Design for the Perioperative Cognitive Enhancement (PROTECT) Trial | Atkins, K. J. Scott, D. A. Silbert, B. Pike, K. E. Evered, L. | J Alzheimers Dis | 2021 |
Anesthesia and analgesia |
| Prevalence of Severe Neurocognitive Impairment and Its Association with Socio-Demographics and Functionality Among Ugandan Older Persons: A Hospital-Based Study | Atim, L. M. Kaggwa, M. M. Mamun, M. A. Ashaba, S. Maling, S. | Clin Interv Aging | 2021 |
Aged |
| Clinical Aspects of Palliative Sedation in Prospective Studies. A Systematic Review | Arantzamendi, M. Belar, A. Payne, S. Rijpstra, M. Preston, N. Menten, J. Van der Elst, M. Radbruch, L. Hasselaar, J. Centeno, C. | J Pain Symptom Manage | 2021 |
*Hospice and Palliative Care Nursing |
| Psychometric Properties of Nursing Delirium Screening Scale in Patients Admitted to Intensive Care Units | Amirajam, Z. Asadi-Noran, E. Molaei, B. Adiban, V. Heidarzadeh, M. Hassanpour-Darghah, M. | Indian J Crit Care Med | 2021 |
Delirium |
| Delirium researchers' perspectives of the challenges in delirium biomarker research: A qualitative study | Amgarth-Duff, I. Hosie, A. Caplan, G. A. Agar, M. | PLoS One | 2021 |
Biomarkers/blood |
| Addition of Valerian and Lemon Balm Extract to Quetiapine Reduces Agitation in Critically Ill Patients with Delirium: A Pilot Randomized Clinical Trial | Alikiaie, B. Shahmoradi, E. Yekdaneh, A. Mousavi, S. | Indian J Crit Care Med | 2021 |
Delirium |
| Spinal block and delirium in oncologic patients after laparoscopic surgery in the Trendelenburg position: A randomized controlled trial | Mitsunaga, J. K. Junior Calsavara, V. F. Onari, E. S. Arantes, V. M. Akamine, C. P. Handa, A. M. Quezada, M. M. C. Ito, F. Y. Porto, A. C. S. Giroud Joaquim, E. H. Nakamura, G. | PLoS One | 2021 | |
| Perioperative Vascular Biomarker Profiling in Elective Surgery Patients Developing Postoperative Delirium: A Prospective Cohort Study | Menzenbach, J. Frede, S. Petras, J. Guttenthaler, V. Kirfel, A. Neumann, C. Mayr, A. Wittmann, M. Coburn, M. Klaschik, S. Hilbert, T. | Biomedicines | 2021 |
Ccl2 |
| Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery | McKay, T. B. Rhee, J. Colon, K. Adelsberger, K. Turco, I. Mueller, A. Qu, J. Akeju, O. | J Cardiothorac Vasc Anesth | 2021 |
Fgf |
| Stratified delirium risk using prescription medication data in a state-wide cohort | McCoy, T. H., Jr. Castro, V. M. Hart, K. L. Perlis, R. H. | Gen Hosp Psychiatry | 2021 |
Cohort study |
| Nutritional Risk at intensive care unit admission and outcomes in survivors of critical illness | Mart, M. F. Girard, T. D. Thompson, J. L. Whitten-Vile, H. Raman, R. Pandharipande, P. P. Heyland, D. K. Ely, E. W. Brummel, N. E. | Clin Nutr | 2021 |
Activities of daily living |
| Risk Factors for Delirium Are Different in the Very Old: A Comparative One-Year Prospective Cohort Study of 5,831 Patients | Marquetand, J. Bode, L. Fuchs, S. Hildenbrand, F. Ernst, J. von Kaenel, R. Boettger, S. | Front Psychiatry | 2021 |
comparison |
| Plasma interleukin-6 is a potential predictive biomarker for postoperative delirium among acute type a aortic dissection patients treated with open surgical repair | Lv, X. C. Lin, Y. Wu, Q. S. Wang, L. Hou, Y. T. Dong, Y. Chen, L. W. | J Cardiothorac Surg | 2021 |
Adult |
| Association of early and later depressive symptoms with functional outcome after ischemic stroke | Lopatkiewicz, A. M. Pera, J. Slowik, A. Dziedzic, T. | J Neural Transm (Vienna) | 2021 |
Cognitive decline |
| Development and validation of a postoperative delirium prediction model for pediatric patients: A prospective, observational, single-center study | Lin, N. Liu, K. Feng, J. Chen, R. Ying, Y. Lv, D. Zhou, Y. Xu, H. | Medicine (Baltimore) | 2021 |
Adolescent |
| Patients' experiences of delirium: A systematic review and meta-summary of qualitative research | Kuusisto-Gussmann, E. Höckelmann, C. von der Lühe, V. Schmädig, R. Baltes, M. Stephan, A. | J Adv Nurs | 2021 |
delirium |
| Effects of case-based confusion assessment methods for intensive care unit training on delirium knowledge and delirium assessment accuracy of intensive care units: A quasi-experimental study | Kim, Y. N. Kim, D. H. | Nurse Educ Today | 2021 |
Critical Illness |
| Bridging the Gap Between the Intensive Care Unit and the Acute Medical Care Unit | Kim, E. Kast, C. Afroz-Hossain, A. Qiu, M. Pappas, K. Sinvani, L. | Am J Crit Care | 2021 | |
| Preoperative MRI brain phenotypes are related to postoperative delirium in older individuals | Kant, I. M. J. Slooter, A. J. C. Jaarsma-Coes, M. van Montfort, S. J. T. Witkamp, T. D. Pasma, W. Hendrikse, J. de Bresser, J. | Neurobiol Aging | 2021 |
Brain phenotypes |
| Pre-Existing Psychiatric Illness Is Associated With an Increased Risk of Delirium in Patients With Acute Respiratory Distress Syndrome | Kalra, S. S. Jaber, J. Alzghoul, B. N. Hyde, R. Parikh, S. Urbine, D. Reddy, R. | J Intensive Care Med | 2021 |
Ards |
| Development and internal validation of a predictive model of cognitive decline 36 months following elective surgery | Jones, R. N. Tommet, D. Steingrimsson, J. Racine, A. M. Fong, T. G. Gou, Y. Hshieh, T. T. Metzger, E. D. Schmitt, E. M. Tabloski, P. A. Travison, T. G. Vasunilashorn, S. M. Abdeen, A. Earp, B. Kunze, L. Lange, J. Vlassakov, K. Dickerson, B. C. Marcantonio | Alzheimers Dement (Amst) | 2021 |
cognitive decline |
| The performance of the Dutch Safety Management System frailty tool to predict the risk of readmission or mortality in older hospitalised cardiac patients | Jepma, P. Verweij, L. Tijssen, A. Heymans, M. W. Flierman, I. Latour, C. H. M. Peters, R. J. G. Scholte Op Reimer, W. J. M. Buurman, B. M. Ter Riet, G. | BMC Geriatr | 2021 |
Aged |
| Outcomes of transcatheter aortic valve replacement in patients with cognitive dysfunction | Jain, V. Kalra, A. Panhwar, M. S. Bansal, A. Nowacki, A. Bhatia, K. Gupta, T. Ineman, N. L. Khan, S. U. Krishnaswamy, A. Reed, G. W. Puri, R. Kapadia, S. R. Svensson, L. G. Kanaa, N. A. Lahorra, J. A. | J Am Geriatr Soc | 2021 |
cognitive impairment |
| The Importance of Delirium and Delirium Prevention in Older Adults During Lockdowns | Inouye, S. K. | JAMA | 2021 |
Aged |
| Association of Pain With Atrial Fibrillation and Delirium After Cardiac Surgery: A DECADE Sub-Study | Ince, I. Chiu, A. Sagir, A. Chahar, P. Lin, J. Douglas, A. Adi, A. Fang, J. Mao, G. Turan, A. | J Cardiothorac Vasc Anesth | 2021 |
atrial fibrillation |
| Higher versus lower mean arterial pressure target management in older patients having non-cardiothoracic surgery: A prospective randomized controlled trial | Hu, A. M. Qiu, Y. Zhang, P. Zhao, R. Li, S. T. Zhang, Y. X. Zheng, Z. H. Hu, B. L. Yang, Y. L. Zhang, Z. J. | J Clin Anesth | 2021 |
Aged |
| Are Patients Taking Benzodiazepines at Increased Risk for Complications Following Primary Total Knee Arthroplasty? | Hernandez, N. M. Cunningham, D. J. Hinton, Z. W. Wu, C. J. Seyler, T. M. | J Arthroplasty | 2021 |
Arthroplasty, Replacement, Knee/adverse effects |
| Preoperative medication use and development of postoperative delirium and cognitive dysfunction | Heinrich, M. Nottbrock, A. Borchers, F. Mörgeli, R. Kruppa, J. Winterer, G. Slooter, A. J. C. Spies, C. | Clin Transl Sci | 2021 | |
| Radiological, Chemical, and Pharmacological Cholinergic System Parameters and Neurocognitive Disorders in Older Presurgical Adults | Heinrich, M. Müller, A. Lammers-Lietz, F. Borchers, F. Mörgeli, R. Kruppa, J. Zacharias, N. Winterer, G. Slooter, A. J. C. Spies, C. D. | J Gerontol A Biol Sci Med Sci | 2021 |
Anticholinergic medication |
| Predictors and Sequelae of Postoperative Delirium in a Geriatric Patient Population With Hip Fracture | Haynes, M. S. Alder, K. D. Toombs, C. Amakiri, I. C. Rubin, L. E. Grauer, J. N | J Am Acad Orthop Surg Glob Res Rev | 2021 |
Postoperative Delirium Hip fracture Dementia Geriatric Preoperative dementia |
| Visual Analytics in Delirium Management | Hackl, W. O. Netzer, M. Nantschev, R. Schaller, M. Ammenwerth, E. | Stud Health Technol Inform | 2021 |
Aged |
| Characterizing Sleep Disruption and Delirium in Children After Cardiac Surgery: A Feasibility Study | Gregory, J. L. Brown, A. T. Kudchadkar, S. R. | Pediatr Crit Care Med | 2021 | |
| One-Year Medicare Costs Associated With Delirium in Older Patients Undergoing Major Elective Surgery | Gou, R. Y. Hshieh, T. T. Marcantonio, E. R. Cooper, Z. Jones, R. N. Travison, T. G. Fong, T. G. Abdeen, A. Lange, J. Earp, B. Schmitt, E. M. Leslie, D. L. Inouye, S. K. | JAMA Surg | 2021 | |
| Implementing Delirium Screening in an Intermediate Care Unit | Gaa, C. A. Akintade, B. F. | J Dr Nurs Pract | 2021 |
confusion assessment method |
| Malocclusion of Molar Teeth Is Associated with Activities of Daily Living Loss and Delirium in Elderly Critically Ill Older Patients | Fujinami, Y. Hifumi, T. Ono, Y. Saito, M. Okazaki, T. Shinohara, N. Akiyama, K. Kunikata, M. Inoue, S. Kotani, J. Kuroda, Y. | J Clin Med | 2021 |
ICU prognosis |
| Electroencephalography of mechanically ventilated patients at high risk of delirium | Eskioglou, E. Iaquaniello, C. Alvarez, V. Rüegg, S. Schindler, K. Rossetti, A. O. Oddo, M. | Acta Neurol Scand | 2021 |
Eeg |
| Risk Factors and Antipsychotic Usage Patterns Associated With Terminal Delirium in a Veteran Long-Term Care Hospice Population | Ellsworth, E. M. Bacigalupo, K. J. Palla, K. R. Limaye, S. S. Walkosz, M. J. Szczecinski, S. T. Suda, K. J. | Fed Pract | 2021 | |
| Does cognitive decline/dementia increase Delirium risk after stroke? | Ding, G. Hua, S. Chen, J. Yang, S. Xie, R. | Psychogeriatrics | 2021 |
Cognitive Dysfunction |
| Heterogeneity in design and analysis of ICU delirium randomized trials: a systematic review | Colantuoni, E. Koneru, M. Akhlaghi, N. Li, X. Hashem, M. D. Dinglas, V. D. Neufeld, K. J. Harhay, M. O. Needham, D. M. | Trials | 2021 |
Adult |
| The frequency and quality of delirium documentation in discharge summaries | Chuen, V. L. Chan, A. C. H. Ma, J. Alibhai, S. M. H. Chau, V. | BMC Geriatr | 2021 |
Delirium/diagnosis/epidemiology |
| Using data linkage for national surveillance of clinical quality indicators for dementia care among Australian aged care users | Cations, M. Lang, C. Ward, S. A. Caughey, G. E. Crotty, M. Whitehead, C. Ahern, S. Maddison, J. Inacio, M. C. | Sci Rep | 2021 | |
| Geriatric fracture centre vs usual care after proximal femur fracture in older patients: what are the benefits? Results of a large international prospective multicentre study | Blauth, M. Joeris, A. Rometsch, E. Espinoza-Rebmann, K. Wattanapanom, P. Jarayabhand, R. Poeze, M. Wong, M. K. Kwek, E. B. K. Hegeman, J. H. Perez-Uribarri, C. Guerado, E. Revak, T. J. Zohner, S. Joseph, D. Gosch, M. | BMJ Open | 2021 |
Aged |
| Effects of dexmedetomidine on neurocognitive disturbance after elective non-cardiac surgery in senile patients: a systematic review and meta-analysis | Bi, X. Wei, J. Zhang, X. | J Int Med Res | 2021 |
China |
| Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients (Review) | Burton JK, Craig LE, Yong SQ, Siddiqi N, Teale EA, Woodhouse R, Barugh AJ, Shepherd AM, Brunton A, Freeman SC, Sutton AJ, Quinn TJ | Cochrane Database of Systematic Reviews | 2021 | |
| Incidence and risk factors for postoperative delirium after liver transplantation: a systematic review and meta-analysis | Zhou, S. Deng, F. Zhang, J. Chen, G. | Eur Rev Med Pharmacol Sci | 2021 | |
| The perioperative application of continuous cerebral autoregulation monitoring for cerebral protection in elderly patients | Zhang, Y. Tan, J. Li, P. Zhang, X. Yang, Y. Liu, Y. Fu, Q. Cao, J. Mi, W. Zhang, H. Li, H. | Ann Palliat Med | 2021 |
Aged |
| Prospective Randomized Controlled Pilot Study of High-Intensity Lightbox Phototherapy to Prevent ICU-Acquired Delirium Incidence | Zhang, K. S. Pelleg, T. Hussain, S. Kollipara, V. Loschner, A. Foroozesh, M. B. Rubio, E. Biscardi, F. Ie, S. R. | Cureus | 2021 |
bright light therapy |
| Neurocognitive disorders in the elderly: altered functional resting-state hyperconnectivities in postoperative delirium patients | Winterer, J. M. Ofosu, K. Borchers, F. Hadzidiakos, D. Lammers-Lietz, F. Spies, C. Winterer, G. Zacharias, N. | Transl Psychiatry | 2021 |
Aged |
| Relationships between preoperative cortical thickness, postoperative electroencephalogram slowing, and postoperative delirium | White, M. F. Tanabe, S. Casey, C. Parker, M. Bo, A. Kunkel, D. Nair, V. Pearce, R. A. Lennertz, R. Prabhakaran, V. Lindroth, H. Sanders, R. D. | Br J Anaesth | 2021 |
cortical slowing |
| COVID-19 in adults with dementia: clinical features and risk factors of mortality-a clinical cohort study on 125 patients | Vrillon, A. Mhanna, E. Aveneau, C. Lebozec, M. Grosset, L. Nankam, D. Albuquerque, F. Razou Feroldi, R. Maakaroun, B. Pissareva, I. Cherni Gherissi, D. Azuar, J. François, V. Hourrègue, C. Dumurgier, J. Volpe-Gillot, L. Paquet, C. | Alzheimers Res Ther | 2021 |
Aged, 80 and over |
| Risk Factors for Delirium after Vascular Surgery: A Systematic Review and Meta-Analysis | Visser, L. Prent, A. Banning, L. B. D. van Leeuwen, B. L. Zeebregts, C. J. Pol, R. A. | Ann Vasc Surg | 2021 | |
| Etiologies of Delirium in Consecutive COVID-19 Inpatients and the Relationship Between Severity of Delirium and COVID-19 in a Prospective Study With Follow-Up | Velásquez-Tirado, J. D. Trzepacz, P. T. Franco, J. G. | J Neuropsychiatry Clin Neurosci | 2021 |
Covid-19 |
| Increased Emergency Department Hallway Length of Stay is Associated with Development of Delirium | van Loveren, K. Singla, A. Sinvani, L. Calandrella, C. Perera, T. Brave, M. Becker, L. Li, T. | West J Emerg Med | 2021 |
Adolescent |
| Delirium in Children Undergoing Hematopoietic Cell Transplantation: A Multi-Institutional Point Prevalence Study | Traube, C. Gerber, L. M. Mauer, E. A. Small, K. Broglie, L. Chopra, Y. R. Duncan, C. N. Ebens, C. L. Fitzgerald, J. C. Freedman, J. L. Hudspeth, M. P. Hurley, C. Mahadeo, K. M. McArthur, J. Shapiro, M. C. Sharron, M. P. Wall, D. A. Zinter, M. S. Greenwald | Front Oncol | 2021 |
cancer |
| Agreement Between the Mini-Cog in the Preoperative Clinic and on the Day of Surgery and Association With Postanesthesia Care Unit Delirium: A Cohort Study of Cognitive Screening in Older Adults | Tiwary, N. Treggiari, M. M. Yanez, N. D. Kirsch, J. R. Tekkali, P. Taylor, C. C. Schenning, K. J. | Anesth Analg | 2021 |
Aged |
| A qualitative analysis of clinicians' communication strategies with family members of patients experiencing hospital-acquired delirium | Taylor, G. B. Radhakrishnan, N. Fisher, C. L. Price, C. Tighe, P. Le, T. Bylund, C. L. | Geriatr Nurs | 2021 | |
| A scalable approach for developing clinical risk prediction applications in different hospitals | Sun, H. Depraetere, K. Meesseman, L. De Roo, J. Vanbiervliet, M. De Baerdemaeker, J. Muys, H. von Dossow, V. Hulde, N. Szymanowsky, R. | J Biomed Inform | 2021 |
Acute kidney injury |
| The Relative Impact of Specific Postoperative Complications on Older Patients Undergoing Hip Fracture Repair | Stahl, C. C. Funk, L. M. Schumacher, J. R. Zarzaur, B. L. Scarborough, J. E. | Jt Comm J Qual Patient Saf | 2021 | |
| Brain MRI after critical care admission: A longitudinal imaging study | Sprung, J. Warner, D. O. Knopman, D. S. Petersen, R. C. Mielke, M. M. Jack, C. R., Jr. Martin, D. P. Hanson, A. C. Schroeder, D. R. Przybelski, S. A. Schulte, P. J. Laporta, M. L. Weingarten, T. N. Vemuri, P. | J Crit Care | 2021 |
AD-signature cortex |
| Effect of age on dexmedetomidine treatment for ventilated patients with sepsis: a post-hoc analysis of the DESIRE trial | Sato, T. Kawazoe, Y. Miyagawa, N. Yokokawa, Y. Kushimoto, S. Miyamoto, K. Ohta, Y. Morimoto, T. Yamamura, H. | Acute Med Surg | 2021 |
Delirium |
| Effects of comprehensive geriatric care models on postoperative outcomes in geriatric surgical patients: a systematic review and meta-analysis | Saripella, A. Wasef, S. Nagappa, M. Riazi, S. Englesakis, M. Wong, J. Chung, F. | BMC Anesthesiol | 2021 |
Adverse outcomes |
| Influence of Age on Postoperative Neurological Outcomes after Surgery of Acute Type A Aortic Dissection | Salem, M. Salib, M. Friedrich, C. Salem, M. Puehler, T. Schoettler, J. Schoeneich, F. Cremer, J. Haneya, A. | J Clin Med | 2021 |
acute type A aortic dissection |
| Associations between caregiver-detected delirium and symptoms of depression and anxiety in family caregivers of critically ill patients: a cross-sectional study | Rosgen, B. K. Krewulak, K. D. Davidson, J. E. Ely, E. W. Stelfox, H. T. Fiest, K. M. | BMC Psychiatry | 2021 |
Adult |
| A Core Outcome Set for Research Evaluating Interventions to Prevent and/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS) | Rose, L. Burry, L. Agar, M. Campbell, N. L. Clarke, M. Lee, J. Marshall, J. C. Devlin, J. W. Blackwood, B. Needham, D. M. Siddiqi, N. Page, V. | Crit Care Med | 2021 | |
| Postoperative delirium is associated with decreased recovery of ambulation one-month after surgery | Robinson, T. N. Kovar, A. Carmichael, H. Overbey, D. M. Goode, C. M. Jones, T. S. | Am J Surg | 2021 |
Aged |
| Emergence delirium in children: a Brazilian survey | Quintão, V. C. Sales, C. K. O. Herrera, E. M. Ellerkmann, R. K. Rosen, H. D. Carmona, M. J. C. | Braz J Anesthesiol | 2021 |
Anesthesia |
| Perioperative dexmedetomidine administration to prevent delirium in adults after non-cardiac surgery: A systematic review and meta-analysis | Qin, C. Jiang, Y. Lin, C. Li, A. Liu, J. | J Clin Anesth | 2021 |
Adult |
| Probable Delirium as a Risk Factor for Adverse Surgical Outcomes in Geriatric Patients With Acute Hip Fracture: Preoperative Assessment Using a Short Screening Tool | Perkins, J. L. Perera, S. Beach, M. Esper, S. A. Gruen, G. S. Neft, M. | AANA J | 2021 |
Adverse outcomes |
| Cognitive Stimulation in an Intensive Care Unit: A Qualitative Evaluation of Barriers to and Facilitators of Implementation | Parker, A. M. Aldabain, L. Akhlaghi, N. Glover, M. Yost, S. Velaetis, M. Lavezza, A. Mantheiy, E. Albert, K. Needham, D. M. | Crit Care Nurse | 2021 | |
| Does Delirium Phenomenology in Persons with Advanced Cancer Follow a Specific Pattern? | Pallotti, M. C. Lopez-Fidalgo, J. Centeno, C. Celin, D. Biasco, G. Giovannini, M. Maltoni, M. Noguera, A. | J Palliat Med | 2021 |
Mdas |
| Dexmedetomidine, Delirium, and Adverse Outcomes: Analysis of the STS Adult Cardiac Surgery Database | Pal, N. Abernathy, J. H., 3rd Taylor, M. A. Bollen, B. A. Shah, A. S. Feng, X. Shotwell, M. S. Kertai, M. D. | Ann Thorac Surg | 2021 |
cardiac surgery |
| Factors associated with delirium after cardiac surgery: A prospective cohort study | Ordóñez-Velasco, L. M. Hernández-Leiva, E. | Ann Card Anaesth | 2021 |
Body mass index |
| Baseline sleep as a predictor of delirium after surgical aortic valve replacement: A feasibility study | Oldham, M. A. Pigeon, W. R. Chapman, B. Yurcheshen, M. Knight, P. A. Lee, H. B. | Gen Hosp Psychiatry | 2021 |
Apnea/hypopnea index |
| What Does a Diagnosis of Depression Mean for Patients Undergoing Colorectal Surgery? | Oduyale, O. K. Eltahir, A. A. Stem, M. Prince, E. Zhang, G. Q. Safar, B. Efron, J. E. Atallah, C. | J Surg Res | 2021 |
Colorectal surgery |
| A randomized double-blind placebo-controlled trial of intravenous thiamine for prevention of delirium following allogeneic hematopoietic stem cell transplantation | Nakamura, Z. M. Deal, A. M. Park, E. M. Quillen, L. J. Chien, S. A. Stanton, K. E. McCabe, S. D. Heiling, H. M. Wood, W. A. Shea, T. C. Rosenstein, D. L. | J Psychosom Res | 2021 |
Cognitive impairment |
| The 4-DSD: A New Tool to Assess Delirium Superimposed on Moderate to Severe Dementia | Morandi, A. Grossi, E. Lucchi, E. Zambon, A. Faraci, B. Severgnini, J. MacLullich, A. Smith, H. Pandharipande, P. Rizzini, A. Galeazzi, M. Massariello, F. Corradi, S. Raccichini, A. Scrimieri, A. Morichi, V. Gentile, S. Lucchini, F. Pecorella, L. Mossello | J Am Med Dir Assoc | 2021 |
Delirium |
| Are dexmedetomidine and olanzapine suitable to control delirium in critically ill elderly patients? A retrospective cohort study | Liu, S. Zhao, R. Yang, R. Zhao, H. Ji, C. Duan, M. Liu, J. | Biomed Pharmacother | 2021 |
Critical illness |
| Association between glucose variability and postoperative delirium in acute aortic dissection patients: an observational study | Lin, Y. J. Lin, L. Y. Peng, Y. C. Zhang, H. R. Chen, L. W. Huang, X. Z. Chen, Q. | J Cardiothorac Surg | 2021 |
Acute Disease |
| Frailty is associated with a higher risk of developing delirium and cognitive impairment among patients with diabetic kidney disease: A longitudinal population-based cohort study | Lee, S. Y. Wang, J. Chao, C. T. Chien, K. L. Huang, J. W. | Diabet Med | 2021 |
chronic kidney disease |
| Multi-Component Care Bundle in Geriatric Fracture Hip for Reducing Post-Operative Delirium | Lam, D. M. H. Wang, C. Lee, A. K. H. Chung, Y. F. Lau, T. W. Fang, C. Leung, F. Chan, T. C. W. | Geriatr Orthop Surg Rehabil | 2021 |
delirium |
| Occurrence of Delirium during ECMO Therapy in a Critical Care Unit in Poland-A Cross-Sectional Pilot Study | Krupa, S. Friganovic, A. Mędrzycka-Dąbrowska, W. | Int J Environ Res Public Health | 2021 |
Critical Care |
| Steroids to reduce the impact on delirium (STRIDE): a double-blind, randomised, placebo-controlled feasibility trial of pre-operative dexamethasone in people with hip fracture | Kluger, M. T. Skarin, M. Collier, J. Rice, D. A. McNair, P. J. Seow, M. Y. Connolly, M. J. | Anaesthesia | 2021 |
delirium |
| Elevated plasma levels of galectin-3 binding protein are associated with post-stroke delirium - A pilot study | Klimiec-Moskal, E. Pasinska, P. Kowalska, K. Klimkowicz-Mrowiec, A. Pera, J. Slowik, A. Dziedzic, T. | J Neuroimmunol | 2021 |
Delirium |
| Postoperative delirium after cardiac surgery of elderly patients as an independent risk factor for prolonged length of stay in intensive care unit and in hospital | Kirfel, A. Menzenbach, J. Guttenthaler, V. Feggeler, J. Mayr, A. Coburn, M. Wittmann, M. | Aging Clin Exp Res | 2021 |
Cardiac surgery |
| ED-DEL: Development of a change package and toolkit for delirium in the emergency department | Kennedy, M. Webb, M. Gartaganis, S. Hwang, U. Biese, K. Stuck, A. Lesser, A. Hshieh, T. Inouye, S. K. | J Am Coll Emerg Physicians Open | 2021 |
aging |
| Elevated Monocyte Chemoattractant Protein-1 as the Independent Risk Factor of Delirium after Cardiac Surgery. A Prospective Cohort Study | Kaźmierski, J. Miler, P. Pawlak, A. Jerczyńska, H. Woźniak, J. Frankowska, E. Brzezińska, A. Woźniak, K. Krejca, M. Wilczyński, M. | J Clin Med | 2021 |
cardiac surgery |
| Prevalence of and factors associated with physical restraint use in the intensive care unit: a multicenter prospective observational study in Japan | Kawai, Y. Hamamoto, M. Miura, A. Yamaguchi, M. Masuda, Y. Iwata, M. Kanbe, M. Ikematsu, Y. | Intern Emerg Med | 2021 |
Associated factors |
| Added value of anxiolytic benzodiazepines in predictive models on severe delirium in patients with acute decompensated heart failure: A retrospective analysis | Kawada, K. Fukuda, H. Kubo, T. Ohta, T. Ishida, T. Morisawa, S. Kawazoe, T. Okamoto, M. Fujita, H. Jobu, K. Morita, Y. Ueba, T. Kitaoka, H. Miyamura, M. | PLoS One | 2021 |