What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Evaluating Pain, Opioids, and Delirium in Critically Ill Older Adults | Pavone, K. J. Jablonski, J. Cacchione, P. Z. Polomano, R. C. Compton, P. | Clin Nurs Res | 2021 |
Aged |
| Optimizing the Recognition and Treatment of In-Hospital Stroke: Evaluation of the 2CAN Score | Parrino, C. R. Noles, A. Lalla, R. Mehndiratta, P. Phipps, M. Cronin, C. Cole, J. Wozniak, M. Yarbrough, K. Chaturvedi, S. | J Stroke Cerebrovasc Dis | 2021 |
Aged |
| Cohort Analysis of the Association of Delirium Severity with Cerebrospinal Fluid Amyloid-Tau-Neurodegeneration Pathologies | Parker, M. White, M. Casey, C. Kunkel, D. Bo, A. Blennow, K. Zetterberg, H. Pearce, R. A. Lennertz, R. Sanders, R. D. | J Gerontol A Biol Sci Med Sci | 2021 |
Biology of aging, Biomarkers, Dementia |
| The Delirium Observation Screening Scale: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy | Park, J. Jeong, E. Lee, J | Clin Nurs Res | 2021 |
*Delirium/diagnosis |
| Higher neutrophil-to-lymphocyte ratio, mean platelet volume, and platelet distribution width are associated with postoperative delirium in patients undergoing esophagectomy: a retrospective observational study | Oyama, T. Kinoshita, H. Takekawa, D. Saito, J. Kushikata, T. Hirota, K. | J Anesth | 2021 |
Esophagectomy |
| The predictive value of the 'VMS frail older patients' for adverse outcomes in geriatric inpatients | Oud, F. M. M. Wolzak, N. K. Spies, P. E. Zaag-Loonen, H. J. V. van Munster, B. C. | Arch Gerontol Geriatr | 2021 |
Aged |
| Impact of ABCDE Bundle Implementation in the Intensive Care Unit on Specific Patient Costs | Otusanya, O. T. Hsieh, S. J. Gong, M. N. Gershengorn, H. B. | J Intensive Care Med | 2021 |
cost and cost analysis |
| Use of Suvorexant and Antipsychotics in the Treatment of Delirium After Infectious Diseases: A Retrospective Study | Okino, K. Yamada, H. Tomioka, H. Nozaki, S. Iwanami, A. Inamoto, A. | J Clin Psychopharmacol | 2021 |
Antipsychotics, Suvorexant, Delirium, Infectious Disease, C-reactive protein, White blood cell count |
| The assessment of risk factors for postoperative delirium using cubic spline curves in gastroenterological surgery | Okawa, Y. Tanaka, K. Nakanishi, Y. Asano, T. Noji, T. Ebihara, Y. Kurashima, Y. Nakamura, T. Murakami, S. Tsuchikawa, T. Okamura, K. Shichinohe, T. Hirano, S. | Surg Today | 2021 |
Cubic spline curve |
| Delirium and Long-Term Outcomes among Survivors of Extracorporeal Membrane Oxygenation Therapy: A Nationwide Cohort Study in South Korea | Oh, T. K. Park, H. Y. Song, I. A. | J Intensive Care Med | 2021 |
Critical Care |
| The Impact of Earplugs and Eye Masks on Sleep Quality in Surgical ICU Patients at Risk for Frequent Awakenings | Obanor, O. O. McBroom, M. M. Elia, J. M. Ahmed, F. Sasaki, J. D. Murphy, K. M. Chalk, S. Menard, G. A. Pratt, N. V. Venkatachalam, A. M. Romito, B. T. | Crit Care Med | 2021 |
Adult |
| Interventions to support recovery following an episode of delirium: A realist synthesis | O'Rourke, G. Parker, D. Anderson, R. Morgan-Trimmer, S. Allan, L | Aging Ment Health | 2021 |
Aged |
| Preoperative inflammatory mediators and postoperative delirium: systematic review and meta-analysis | Noah, A. M. Almghairbi, D. Evley, R. Moppett, I. K. | Br J Anaesth | 2021 |
Aged |
| Development of an algorithm for assessing fall risk in a Japanese inpatient population | Nakanishi, T. Ikeda, T. Nakamura, T. Yamanouchi, Y. Chikamoto, A. Usuku, K. | Sci Rep | 2021 |
Disease prevention, Geriatrics, Public health |
| Relationship among melatonin, postoperative delirium, and postoperative cognitive dysfunction | Mu, S. Wu, Y. Wu, A. | Ann Palliat Med | 2021 |
*Cognition Disorders |
| Hospital complications among older adults: Better processes could reduce the risk of delirium | Moura Junior, V. Westover, M. B. Li, F. Kimchi, E. Kennedy, M. Benson, N. M. Moura, L. M. Hsu, J. | Health Serv Manage Res | 2021 |
access/demand/utilization of services |
| Precipitated Withdrawal, Delirium, and Cerebellar Stroke: The Pharmacology of Buprenorphine Induction in Non-pharmaceutical Fentanyl and the Neuropsychiatric Manifestations of Cerebellar Stroke | Montalvo, C. von Horn, A. Lane, C. E. Weinstein, Z. M. Sharma, M. Suzuki, J. | Harv Rev Psychiatry | 2021 | |
| The effect of foot massage on the level of consciousness and delirium of intensive care patients: A randomized single-blind controlled trial | Momeni, M. Arab, M. Dehghan, M. Ahmadinejad, M. | J Bodyw Mov Ther | 2021 |
*Consciousness |
| Intravenous patient-controlled analgesia does not increase the risk of postoperative delirium compared to patient-controlled epidural analgesia: a propensity score-matched retrospective cohort study | Miyoshi, H. Nakamura, R. Noda, Y. Yokomi, H. Kamiya, S. Morio, A. Watanabe, T. Narasaki, S. Toyota, Y. Saeki, N. Hamada, H. Tsutsumi, Y. M. | Ann Palliat Med | 2021 |
Patient-controlled analgesia (PCA) |
| Standardized Semistructured Psychosocial Evaluation Before Stem Cell Transplantation Predicts Delirium After Transplant | Mishkin, A. D. Schmajuk, M. Reshef, R. Lopez-Pintado, S. Mapara, M. Y. Shapiro, P. A. | J Acad Consult Liaison Psychiatry | 2021 |
*cancer (PSY0140) |
| Pattern of Brain Injury in Patients With Thrombotic Thrombocytopenic Purpura in the Precaplacizumab Era | Mirouse, A. Legriel, S. Dumas, G. Labro, G. Veyradier, A. Zafrani, L. Valade, S. Hourmant, Y. Boutboul, D. Darmon, M. Coppo, P. Mariotte, E. Azoulay, E. | Crit Care Med | 2021 |
Adult |
| Postoperative delirium is a risk factor for complications and poor outcome after total hip and knee arthroplasty | Meyer, M. Götz, J. Parik, L. Renkawitz, T. Grifka, J. Maderbacher, G. Kappenschneider, T. Weber, M. | Acta Orthop | 2021 |
Geriatrics, Surgery, Postoperative delirium, Elective joint replacement |
| Why should you stay one night? Prospective observational study of enhanced recovery in elderly patients | Melegari, G. Albertini, G. Romani, A. Malaguti, S. Traccitto, F. Giuliani, E. Cavallini, G. M. Bertellini, E. Barbieri, A. | Aging Clin Exp Res | 2021 |
Aged |
| Inhaled isoflurane via the anaesthetic conserving device versus propofol for sedation of invasively ventilated patients in intensive care units in Germany and Slovenia: an open-label, phase 3, randomised controlled, non-inferiority trial | Meiser, A. Volk, T. Wallenborn, J. Guenther, U. Becher, T. Bracht, H. Schwarzkopf, K. Knafelj, R. Faltlhauser, A. Thal, S. C. Soukup, J. Kellner, P. Drüner, M. Vogelsang, H. Bellgardt, M. Sackey, P. | Lancet Respir Med | 2021 |
Isoflurane, ICU, Propofol, Invasive ventilation, RASS |
| Perioperative Considerations for Patients with a Known Diagnosis of Dementia | McSwain, J. R. Sirianni, J. M. Wilson, S. H. | Adv Anesth | 2021 |
Alzheimer’s dementia |
| The relationship between frailty and delirium: insights from the 2017 Delirium Day study | Mazzola, P. Tassistro, E. Di Santo, S. Rossi, E. Andreano, A. Valsecchi, M. G. Cherubini, A. Marengoni, A. Mossello, E. Bo, M. Inzitari, M. Di Bari, M. Udina, C. Latronico, N. Paolillo, C. Morandi, A. Bellelli, G. | Age Ageing | 2021 |
Aged |
| Absence of Longer Reorientation Times in Patients Undergoing Electroconvulsive Therapy and Concomitant Treatment with Lithium | Martins-Ascencao, R. Rodrigues-Silva, N. Trovão, N. | Clin Psychopharmacol Neurosci | 2021 |
Cognitive dysfunction |
| Period-Prevalence and Risk Factors for Delirium in a Tertiary Referral ICU: A prospective cohort study | Martinez, F. E. Ho, V. W. Brogan, G. Pickering, C. Leung, G. Parrey, J. Charlton, A. | Acute Med | 2021 |
Adult |
| Cross-Cultural Adaptation and Validation of the Italian Version of the Observational Scale of Level of Arousal | Martella, L. A. Carmisciano, L. Giannotti, C. Signori, A. Pontremoli, R. Giusti, M. Gualco, E. Beccati, V. Marengoni, A. Nencioni, A. Monacelli, F. | J Am Med Dir Assoc | 2021 |
Aged |
| Prevalence and management of delirium in community dwelling older people with dementia referred to a memory clinic | Manni, B. Federzoni, L. Zucchi, P. Mussi, C. Inzitari, M. Carda, C. A. Fabbo, A. Morandi, A. | Aging Clin Exp Res | 2021 |
Aged |
| Impact of a Real-Time, Pharmacist-Led, Intensive Care Unit-Based Feedback Intervention on Analgesia and Sedation Quality Among Mechanically Ventilated Patients | Mancheril, B. Kram, B. Schultheis, J. Kram, S. Trammel, M. Liu, B. Jordan, W. Cox, C. E. | J Nurs Care Qual | 2021 |
*Analgesia |
| A New ICU Delirium Prevention Bundle to Reduce the Incidence of Delirium: A Randomized Parallel Group Trial | Malik, A. K. Baidya, D. K. Anand, R. K. Subramaniam, R. | Indian J Crit Care Med | 2021 |
Delirium |
| Risk factors associated with the development of delirium in general ICU patients. A prospective observational study | Lobo-Valbuena, B. Gordo, F. Abella, A. Garcia-Manzanedo, S. Garcia-Arias, M. M. Torrejón, I. Varillas-Delgado, D. Molina, R. | PLoS One | 2021 |
Delirium, ICU Delirium, CAM-ICU, Clinical Frailty Scale, Length of stay, Readmission rate |
| Incidence, Predictors and Outcomes of Delirium in Complicated Type B Aortic Dissection Patients After Thoracic Endovascular Aortic Repai | Liu, J. Yang, F. Luo, S. Li, C. Liu, W. Liu, Y. Huang, W. Xie, E. Chen, L. Su, S. Yang, X. Geng, Q. Luo, J. | Clin Interv Aging | 2021 |
*Aneurysm, Dissecting/surgery |
| Dynamic Delirium Severity Trajectories and Their Association With 2-Year Healthcare Utilization and Mortality Outcomes | Lindroth, H. Mohanty, S. Ortiz, D. Gao, S. Perkins, A. J. Khan, S. H. Boustani, M. A. Khan, B. A. | Crit Care Explor | 2021 |
delirium |
| Intraoperative Oxygen Concentration and Postoperative Delirium After Laparoscopic Gastric and Colorectal Malignancies Surgery: A Randomized, Double-Blind, Controlled Trial | Lin, X. Wang, P. Liu, D. W. Guo, Y. W. Xie, C. H. Wang, B. Dong, R. Sun, L. X. Wang, M. S. Bi, Y. L. | Clin Interv Aging | 2021 |
Aged |
| Incidence of delirium following hospitalization of elderly people with fractures: risk factors and mortality | Lima, B. R. Nunes, B. K. G. Guimarães, Lcdc Almeida, L. F. Pagotto, V. | Rev Esc Enferm USP | 2021 |
Aged |
| Regional Nerve Block Decreases the Incidence of Postoperative Delirium in Elderly Hip Fracture | Lim, E. J. Koh, W. U. Kim, H. Kim, H. J. Shon, H. C. Kim, J. W. | J Clin Med | 2021 |
delirium |
| Effects of perioperative interventions for preventing postoperative delirium: A protocol for systematic review and meta-analysis of randomized controlled trials | Li, X. Wang, Y. Liu, J. Xiong, Y. Chen, S. Han, J. Xie, W. Wu, Q. | Medicine (Baltimore) | 2021 |
Delirium/*prevention & control |
| Developing a machine learning model to identify delirium risk in geriatric internal medicine inpatients | Li, Q. Zhao, Y. Chen, Y. Yue, J. Xiong, Y. | Eur Geriatr Med | 2021 |
Delirium |
| Development and validation of a risk score for predicting postoperative delirium after major abdominal surgery by incorporating preoperative risk factors and surgical Apgar score | Li, G. H. Zhao, L. Lu, Y. Wang, W. Ma, T. Zhang, Y. X. Zhang, H. | J Clin Anesth | 2021 |
Bootstrapping |
| Non-Pharmacological Nursing Interventions for Prevention and Treatment of Delirium in Hospitalized Adult Patients: Systematic Review of Randomized Controlled Trials | Lee, Y. Lee, J. Kim, J. Jung, Y. | Int J Environ Res Public Health | 2021 |
Adult |
| Association of natural light exposure and delirium according to the presence or absence of windows in the intensive care unit | Lee, H. J. Bae, E. Lee, H. Y. Lee, S. M. Lee, J. | Acute Crit Care | 2021 |
delirium |
| Knowledge, barriers, and training needs of nurses working in delirium care | Lee, G. Roh, Y. S | Nurs Crit Care | 2021 |
barrier |
| Causes and Predictors of 30-Day Readmission in Elderly Patients With Delirium | Lau, H. L. Patel, S. D. Garg, N. | Neurol Clin Pract | 2021 |
Readmission rate, Delirium, Hospitalization, Length of stay, Post discharge care |
| Comparison of Antipsychotics for the Treatment of Patients With Delirium and QTc Interval Prolongation: A Clinical Decision Analysis | Kurisu, K. Yoshiuchi, K. | Front Psychiatry | 2021 |
QTc prolongation |
| The Polish Version of the Nursing Delirium Screening Scale (NuDESC PL)-Experience of Using in Nursing Practice in Cardiac Surgery Intensive Care Unit | Krupa, S. Dorota, O. Friganovic, A. Mędrzycka-Dąbrowska, W. Jurek, K. | Int J Environ Res Public Health | 2021 |
Cardiac Surgical Procedures/adverse effects |
| Associations of delirium with urinary tract infections and asymptomatic bacteriuria in adults aged 65 and older: A systematic review and meta-analysis | Krinitski, D. Kasina, R. Klöppel, S. Lenouvel, E. | J Am Geriatr Soc | 2021 |
asymptomatic bacteriuria |
| Prevalence and Factors Affecting Postoperative Delirium in a Neurosurgical Intensive Care Unit | Kose, G. Şirin, K. Inel, M. B. Mertoglu, S. Aksakal, R. Kurucu, Ş | J Neurosci Nurs | 2021 |
Cross-Sectional Studies |
| Effect of hypertension and medication use regularity on postoperative delirium after maxillofacial tumors radical surgery | Kong, S. Wang, J. Xu, H. Wang, K. | Oncotarget | 2021 |
hypertension |
| Perioperative Electroencephalogram Spectral Dynamics Related to Postoperative Delirium in Older Patients | Koch, S. Windmann, V. Chakravarty, S. Kruppa, J. Yürek, F. Brown, E. N. Winterer, G. Spies, C. | Anesth Analg | 2021 |
Electroencephalography, Postoperative delirium, Surgery, Spectral edge frequency |
| Is dislocation following total hip arthroplasty caused while suffering from delirium? | Kobayashi, T. Morimoto, T. Sonohata, M. Mawatari, M. | Nagoya J Med Sci | 2021 |
dislocation |
| Availability of preoperative neutrophil-lymphocyte ratio to predict postoperative delirium after head and neck free-flap reconstruction: A retrospective study | Kinoshita, H. Saito, J. Takekawa, D. Ohyama, T. Kushikata, T. Hirota, K. | PLoS One | 2021 |
Postoperative delirium, ICU delirium, Neutrophil-lymphocyte ratio, Surgery, Length of Stay |
| Delirium risk of histamine-2 receptor antagonists and proton pump inhibitors: A study based on the adverse drug event reporting database in Japan | Kikkawa, N. Sogawa, R. Monji, A. Sumi, S. Murakawa-Hirachi, T. Kubo, T. Eguchi, Y. Miyamoto, Y. Kamo, M. Tobita, S. Yukawa, M. Uchida, R. Egoshi, M. Shimanoe, C. | Gen Hosp Psychiatry | 2021 |
Delirium |
| Delirium in neurosurgery: a systematic review and meta-analysis | Kappen, P. R. Kakar, E. Dirven, C. M. F. van der Jagt, M. Klimek, M. Osse, R. J. Vincent, Apje | Neurosurg Rev | 2021 |
Delirium |
| Risk factors for postoperative delirium and subsyndromal delirium in older patients in the surgical ward: A prospective observational study | Kanno, M. Doi, M. Kubota, K. Kanoya, Y. | PLoS One | 2021 |
Postoperative delirium, Subsyndromal delirium, Surgery, CAM |
| Diagnostic accuracy and clinical applicability of the Swedish version of the 4AT assessment test for delirium detection, in a mixed patient population and setting | Johansson, Y. A. Tsevis, T. Nasic, S. Gillsjö, C. Johansson, L. Bogdanovic, N. Kenne Sarenmalm, E | BMC Geriatr | 2021 |
Aged |
| In-Hospital Delirium as a Prognostic Factor for New Cognitive Disorder in a 1-Year Post-Hip Fracture Follow-Up | Jaatinen, R. Luukkaala, T. Hongisto, M. T. Helminen, H. Nuotio, M. S. | Dement Geriatr Cogn Disord | 2021 |
Cognition |
| Italian version of the short 10/66 dementia diagnostic schedule: a validation study | Ibnidris, A. Piumatti, G. Carlevaro, F. Fadda, M. Magno, F. Magistro, D. Albanese, E. | BMJ Open | 2021 |
Aged |
| A Machine Learning-Based Algorithm for the Prediction of Intensive Care Unit Delirium (PRIDE): Retrospective Study | Hur, S. Ko, R. E. Yoo, J. Ha, J. Cha, W. C. Chung, C. R. | JMIR Med Inform | 2021 |
clinical prediction |
| The effect of evidence-based cluster nursing intervention on the incidences of delirium and the prognoses of ICU patients | Huang, S. Xu, J. Du, Y. Wang, Y. Wei, H. Wei, G. Hu, M. | Am J Transl Res | 2021 |
Evidence-based medicine |
| Impact of dexmedetomidine supplemented analgesia on delirium in patients recovering from orthopedic surgery: A randomized controlled tria | Hong, H. Zhang, D. Z. Li, M. Wang, G. Zhu, S. N. Zhang, Y. Wang, D. X. Sessler, D. I. | BMC Anesthesiol | 2021 |
Delirium |
| Effects of a simulation-based education programme on delirium care for critical care nurses: A randomized controlled trial | Ho, M. H. Yu, L. F. Lin, P. H. Chang, H. R. Traynor, V. Huang, W. C. Montayre, J. Chen, K. H. | J Adv Nurs | 2021 |
Clinical Competence |
| Postoperative Delirium in Older Patients: A Systematic Review of Assessment and Incidence of Postoperative Delirium | Ho, M. H. Nealon, J. Igwe, E. Traynor, V. Chang, H. R. Chen, K. H. Montayre, J. | Worldviews Evid Based Nurs | 2021 |
Aged |
| Harmonization of Four Delirium Instruments: Creating Crosswalks and the Delirium Item-Bank (DEL-IB) | Helfand, B. K. I. Detroyer, E. Milisen, K. Adamis, D. Metzger, E. D. Boudreaux, E. D. Inouye, S. K. Jones, R. N. | Am J Geriatr Psychiatry | 2021 | |
| Association between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients | Heinrich, M. Sieg, M. Kruppa, J. Nürnberg, P. Schreier, P. H. Heilmann-Heimbach, S. Hoffmann, P. Nöthen, M. M. Janke, J. Pischon, T. Slooter, A. J. C. Winterer, G. Spies, C. D. | BMC Med Genomics | 2021 |
Chrm2 |
| Risk of delirium and impaired neurological outcome associated with delay in neurorehabilitation after acquired brain injury | Hansen, P. M. Lauridsen, J. T. Frandsen, N. S. | Dan Med J | 2021 |
*Brain Injuries |
| Prevalence, Risk Factors, and Impact of Delirium on Hospitalized Older Adults With Dementia: A Systematic Review and Meta-Analysis | Han, Q. Y. C. Rodrigues, N. G. Klainin-Yobas, P. Haugan, G. Wu, X. | J Am Med Dir Assoc | 2021 |
Dementia |
| Urinary albumin creatinine ratio associated with postoperative delirium in elderly patients undergoing elective non-cardiac surgery: A prospective observational study | Guan, H. L. Liu, H. Hu, X. Y. Abdul, M. Dai, M. S. Gao, X. Chen, X. F. Zhou, Y. Sun, X. Zhou, J. Li, X. Zhao, Q. Zhang, Q. Q. Wang, J. Han, Y. Cao, J. L. | CNS Neurosci Ther | 2021 |
delirium |
| Cognitive Impairment and Delirium in Older Patients Undergoing Major Head and Neck Surgery | Goldstein, D. P. Blasco, M. de Almeida, J. Su, J. Xu, W. Cohen, M. Sklar, M. Alibhai, S | Otolaryngol Head Neck Surg | 2021 |
clock draw test |
| What prompts patients to present with delirium? | Gibb, K. Krywonos, A. Shah, R. Jha, A. Davis, D. | Eur Geriatr Med | 2021 |
Adult |
| Admission Systolic Blood Pressure Predicts Post-Operative Delirium of Acute Aortic Dissection Patients in the Intensive Care Unit | Fu, Z. Xu, Q. Zhang, C. Bai, H. Chen, X. Zhang, Y. Luo, W. Lin, G. | Int J Gen Med | 2021 |
acute Stanford type A aortic dissection |
| Postoperative Delirium in Patients After Brain Tumor Surgery | French, J. Weber, T. Ge, B. Litofsky, N. S. | World Neurosurg | 2021 |
Confusion assessment method |
| Physical Restraints and Post-Traumatic Stress Disorder in Survivors of Critical Illness. A Systematic Review and Meta-analysis | Franks, Z. M. Alcock, J. A. Lam, T. Haines, K. J. Arora, N. Ramanan, M. | Ann Am Thorac Soc | 2021 |
Adult |
| Long-Term Outcomes in ICU Patients with Delirium: A Population-based Cohort Study | Fiest, K. M. Soo, A. Hee Lee, C. Niven, D. J. Ely, E. W. Doig, C. J. Stelfox, H. T. | Am J Respir Crit Care Med | 2021 |
Adolescent |
| The effect of foot reflexology massage on delirium and sleep quality following cardiac surgery: A randomized clinical trial | Fazlollah, A. Babatabar Darzi, H. Heidaranlu, E. Moradian, S. T. | Complement Ther Med | 2021 |
*Cardiac Surgical Procedures/adverse effects |
| A delirium prevalence audit and a pre and post evaluation of an interprofessional education intervention to increase staff knowledge about delirium in older adults | Ewens, B. Seaman, K. Whitehead, L. Towell-Barnard, A. Young, M. | BMC Nurs | 2021 |
Delirium |
| Anaesthetic depth and delirium after major surgery: a randomised clinical trial | Evered, L. A. Chan, M. T. V. Han, R. Chu, M. H. M. Cheng, B. P. Scott, D. A. Pryor, K. O. Sessler, D. I. Veselis, R. Frampton, C. Sumner, M. Ayeni, A. Myles, P. S. Campbell, D. Leslie, K. Short, T. G. | Br J Anaesth | 2021 |
anaesthesia |
| Association of preoperative frailty with postoperative delirium in elderly orthopedic trauma patients | Esmaeeli, S. Franco-Garcia, E. Akeju, O. Heng, M. Zhou, C. Azocar, R. J. Quraishi, S. A. | Aging Clin Exp Res | 2021 |
Cognition |
| Prevention of postoperative delirium after cardiovascular surgery: A team-based approach | Enomoto, K. Kosaka, S. Kimura, T. Matsubara, M. Kitada, Y. Mieno, M. Okamura, H. | J Thorac Cardiovasc Surg | 2021 |
Delirium Team Approach program |
| Serum Levels of S100β, Neuron-Specific Enolase, Glial Fibrillary Acidic Protein in Kidney Transplant Recipients and Donors: A Prospective Cohort Study | Dinc, B. Yılmaz, V. T. Aslan, M. Aycan, I. O. Kiraz, N. Kisaoglu, A. Dandin, O. Hadimioglu, N. Ertug, Z. | Transplant Proc | 2021 |
Nephrectomy, Kidney transplant, Neuromarkers, Postoperative delirium |
| Delirium and Its Pharmacological Causes in Older People, Part 1 | DeMaagd, G. A. DeMaagd, D. R. Philip, A. Coalter, C. F. | Sr Care Pharm | 2021 |
Aged |
| Potentially inappropriate prescribing in dementia, multi-morbidity and incidence of adverse health outcomes | Delgado, J. Jones, L. Bradley, M. C. Allan, L. M. Ballard, C. Clare, L. Fortinsky, R. H. Hughes, C. M. Melzer, D. | Age Ageing | 2021 |
Aged |
| The Nexus Between Sleep Disturbance and Delirium Among Intensive Care Patients | Delaney, L. J. Litton, E. Van Haren, F. | Crit Care Nurs Clin North Am | 2021 |
Critical Care |
| Opportunities for quality improvement in the morbidity pattern of older adults undergoing pulmonary lobectomy for cancer | De León, L. E. Rochefort, M. M. Bravo-Iñiguez, C. E. Fox, S. W. Tarascio, J. N. Cardin, K. DuMontier, C. Frain, L. N. Jaklitsch, M. T. | J Geriatr Oncol | 2021 |
Aged |
| Palliative sedation in patients with advanced cancer in a specialized unit in a middle-income country: A retrospective cohort study | de Araujo, C. Z. S. de Araújo, L. Z. S. Nassar Junior, A. P. | Palliat Support Care | 2021 |
Cancer |
| Development and Implementation of a Multicomponent Protocol to Promote Sleep and Reduce Delirium in a Medical Intensive Care Unit | Darby, A. Northam, K. Austin, C. A. Chang, L. Campbell-Bright, S | Ann Pharmacother | 2021 |
critical care |
| Effect of Interventions With a Clinical Decision Support System for Hospitalized Older Patients: Systematic Review Mapping Implementation and Design Factors | Damoiseaux-Volman, B. A. van der Velde, N. Ruige, S. G. Romijn, J. A. Abu-Hanna, A. Medlock, S. | JMIR Med Inform | 2021 |
aged |
| Sevoflurane-Remifentanil Versus Propofol-Remifentanil Anesthesia During Noncardiac Surgery for Patients with Coronary Artery Disease - A Prospective Study Between 2016 and 2017 at a Single Center | Dai, Z. Lin, M. Li, Y. Gao, W. Wang, P. Lin, J. Wan, Z. Jiang, Y. | Med Sci Monit | 2021 |
Acute Coronary Syndrome, Coronary Artery Disease, Propofol |
| Symptom trajectories for palliative care inpatients with and without hyperactive delirium in the last week of life | Dai, Y. Walpole, G. Ding, J. Scanlon, C. Ho, L. Khoo, R. H. Huang, C. Cook, A. William, L. Johnson, C. E. | J Adv Nurs | 2021 |
end of life |
| Subtypes of delirium after ischaemic stroke-predisposing factors and outcomes: a prospective observational study (PROPOLIS) | Czyzycki, M. Klimiec-Moskal, E. Chrobak, A. A. Pera, J. Slowik, A. Dziedzic, T. | Eur J Neurol | 2021 |
delirium |
| Effectiveness of a Delirium Prevention Initiative on an Inpatient Neuroscience Unit | Cyrus, T. Wenthold, R. Hall, B. Tu, L. Hedquist, K. Omodt, J. Kozub, E. Guthrie, P. F. | J Neurosci Nurs | 2021 |
Clinical Competence |
| Association Between Cerebral Desaturation and Postoperative Delirium in Thoracotomy With One-Lung Ventilation: A Prospective Cohort Study | Cui, F. Zhao, W. Mu, D. L. Zhao, X. Li, X. Y. Wang, D. X. Jia, H. Q. Dai, F. Meng, L. | Anesth Analg | 2021 |
Aged |
| Factors for Timely Identification of Possible Occurrence of Delirium in Palliative Care: A Prospective Observational Study | Corli, O. Santucci, C. Uggeri, S. Bosetti, C. Cattaneo, M. Ermolli, D. Varrassi, G. Myrcik, D. Paladini, A. Rekatsina, M. Gerosa, C. Ornaghi, M. Roccasalva, A. Santambrogio, P. Beretta, M. | Adv Ther | 2021 |
*Delirium/chemically induced/diagnosis/epidemiology |
| A Processed Electroencephalogram-Based Brain Anesthetic Resistance Index Is Associated With Postoperative Delirium in Older Adults: A Dual Center Study | Cooter Wright, M. Bunning, T. Eleswarpu, S. S. Heflin, M. T. McDonald, S. R. Lagoo-Deenadalayan, S. Whitson, H. E. Martinez-Camblor, P. Deiner, S. G. Berger, M. | Anesth Analg | 2021 |
age factors, anesthesia, methods, delirium, surgery/prevention & control, Electroencephalography, drug effects |
| Implementation and Routinization of the ABCDE Bundle: A Mixed Methods Evaluation | Collinsworth, A. W. Brown, R. Cole, L. Jungeblut, C. Kouznetsova, M. Qiu, T. Richter, K. M. Smith, S. Masica, A. L. | Dimens Crit Care Nurs | 2021 |
Adult |
| Prediction of delirium using data mining: A systematic review | Chua, S. J. Wrigley, S. Hair, C. Sahathevan, R | J Clin Neurosci | 2021 |
Area Under Curve |
| Determinants of Non-emergency Use of Control Interventions in Older Canadian Psychiatric Inpatients: Analysizing the InterRAI Mental Health Electronic Health Records | Cheung, G. Mah, T. M. Barak, Y. Hirdes, J. P. | Front Psychiatry | 2021 |
aggression |
| Assessment of preoperative frailty and identification of patients at risk for postoperative delirium in cardiac intensive care units: a prospective observational study | Cheng, H. W. Liu, C. Y. Chen, Y. S. Shih, C. C. Chen, W. Y. Chiou, A. F. | Eur J Cardiovasc Nurs | 2021 |
Anxiety |
| Preoperative prognostic nutritional index is useful factor for predicting postoperative delirium after primary total joint arthroplasty | Chen, J. Zheng, C. Zhong, J. Zhao, G. Shi, J. Huang, G. Wei, Y. Wang, S. Yu, J. Xia, J. | BMC Musculoskelet Disord | 2021 |
Aged |