What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Exercise for acutely hospitalised older medical patients
- Authors
- Hartley, P. Keating, J. L. Jeffs, K. J. Raymond, M. J. Smith, T. O
- Year
- 2022
- Journal
- Cochrane Database Syst Rev
- Abstract
BACKGROUND: Approximately 30% of hospitalised older adults experience hospital-associated functional decline. Exercise interventions that promote in-hospital activity may prevent deconditioning and thereby maintain physical function during hospitalisation. This is an update of a Cochrane Review first published in 2007. OBJECTIVES: To evaluate the benefits and harms of exercise interventions for acutely hospitalised older medical inpatients on functional ability, quality of life (QoL), participant global assessment of success and adverse events compared to usual care or a sham-control intervention. SEARCH METHODS: We used standard, extensive Cochrane search methods. The latest search date was May 2021. SELECTION CRITERIA: We included randomised or quasi-randomised controlled trials evaluating an in-hospital exercise intervention in people aged 65 years or older admitted to hospital with a general medical condition. We excluded people admitted for elective reasons or surgery. DATA COLLECTION AND ANALYSIS: We used standard Cochrane methods. Our major outcomes were 1. independence with activities of daily living; 2. functional mobility; 3. new incidence of delirium during hospitalisation; 4. QoL; 5. number of falls during hospitalisation; 6. medical deterioration during hospitalisation and 7. participant global assessment of success. Our minor outcomes were 8. death during hospitalisation; 9. musculoskeletal injuries during hospitalisation; 10. hospital length of stay; 11. new institutionalisation at hospital discharge; 12. hospital readmission and 13. walking performance. We used GRADE to assess certainty of evidence for each major outcome. We categorised exercise interventions as: rehabilitation-related activities (interventions designed to increase physical activity or functional recovery, but did not follow a specified exercise protocol); structured exercise (interventions that included an exercise intervention protocol but did not include progressive resistance training); and progressive resistance exercise (interventions that included an element of progressive resistance training). MAIN RESULTS: We included 24 studies (nine rehabilitation-related activity interventions, six structured exercise interventions and nine progressive resistance exercise interventions) with 7511 participants. All studies compared exercise interventions to usual care; two studies, in addition to usual care, used sham interventions. Mean ages ranged from 73 to 88 years, and 58% of participants were women. Several studies were at high risk of bias. The most common domain assessed at high risk of bias was measurement of the outcome, and five studies (21%) were at high risk of bias arising from the randomisation process. Exercise may have no clinically important effect on independence in activities of daily living at discharge from hospital compared to controls (16 studies, 5174 participants; low-certainty evidence). Five studies used the Barthel Index (scale: 0 to 100, higher scores representing greater independence). Mean scores at discharge in the control groups ranged from 42 to 96 points, and independence in activities of daily living was 1.8 points better (0.43 worse to 4.12 better) with exercise compared to controls. The minimally clinical important difference (MCID) is estimated to be 11 points. We are uncertain regarding the effect of exercise on functional mobility at discharge from the hospital compared to controls (8 studies, 2369 participants; very low-certainty evidence). Three studies used the Short Physical Performance Battery (SPPB) (scale: 0 to 12, higher scores representing better function) to measure functional mobility. Mean scores at discharge in the control groups ranged from 3.7 to 4.9 points on the SPPB, and the estimated effect of the exercise interventions was 0.78 points better (0.02 worse to 1.57 better). A change of 1 point on the SPPB represents an MCID. We are uncertain regarding the effect of exercise on the incidence of delirium during hospitalisation compared to controls (7 trials, 2088 participants; very low-certainty evidence). The incidence of delirium during hospitalisation was 88/1091 (81 per 1000) in the control group compared with 70/997 (73 per 1000; range 47 to 114) in the exercise group (RR 0.90, 95% CI 0.58 to 1.41). Exercise interventions may result in a small clinically unimportant improvement in QoL at discharge from the hospital compared to controls (4 studies, 875 participants; low-certainty evidence). Mean QoL on the EuroQol 5 Dimensions (EQ-5D) visual analogue scale (VAS) (scale: 0 to 100, higher scores representing better QoL) ranged between 48.9 and 64.7 in the control group at discharge from the hospital, and QoL was 6.04 points better (0.9 better to 11.18 better) with exercise. A change of 10 points on the EQ-5D VAS represents an MCID. No studies measured participant global assessment of success. Exercise interventions did not affect the risk of falls during hospitalisation (moderate-certainty evidence). The incidence of falls was 31/899 (34 per 1000) in the control group compared with 31/888 (34 per 1000; range 20 to 57) in the exercise group (RR 0.99, 95% CI 0.59 to 1.65). We are uncertain regarding the effect of exercise on the incidence of medical deterioration during hospitalisation (very low-certainty evidence). The incidence of medical deterioration in the control group was 101/1417 (71 per 1000) compared with 96/1313 (73 per 1000; range 44 to 120) in the exercise group (RR 1.02, 95% CI 0.62 to 1.68). Subgroup analyses by different intervention categories and by the use of a sham intervention were not meaningfully different from the main analyses. AUTHORS’ CONCLUSIONS: Exercise may make little difference to independence in activities of daily living or QoL, but probably does not result in more falls in older medical inpatients. We are uncertain about the effect of exercise on functional mobility, incidence of delirium and medical deterioration. Certainty of evidence was limited by risk of bias and inconsistency. Future primary research on the effect of exercise on acute hospitalisation could focus on more consistent and uniform reporting of participant’s characteristics including their baseline level of functional ability, as well as exercise dose, intensity and adherence that may provide an insight into the reasons for the observed inconsistencies in findings.
- PMID
- Keywords
Aged
Aged, 80 and over
Female
Humans
Male
Activities of Daily Living
*Delirium/epidemiology
Exercise
*Quality of Life
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| The economic cost of delirium: A systematic review and quality assessment | Kinchin, I. Mitchell, E. Agar, M. Trépel, D. | Alzheimers Dement | 2021 |
Cost-Benefit Analysis/*economics |
| The Risk of Preoperative Central Nervous System-Acting Medications on Delirium Following Hip or Knee Surgery: A Matched Case-Control Study | Kassie, G. M. Roughead, E. E. Nguyen, T. A. Pratt, N. L. Kalisch Ellett, L. M. | Drug Saf | 2021 |
Preoperative Central Nervous System Delirium Hip or Knee Surgery Matched Case-Control Study |
| Association between ankle brachial index and development of postoperative intensive care unit delirium in patients with peripheral arterial disease | Kang, J. An, J. H. Jeon, H. J. Park, Y. J. | Sci Rep | 2021 |
Aged |
| Incidence and predictors of delirium on the intensive care unit in patients with acute kidney injury, insight from a retrospective registry | Jäckel, M. Aicher, N. Rilinger, J. Bemtgen, X. Widmeier, E. Wengenmayer, T. Duerschmied, D. Biever, P. M. Stachon, P. Bode, C. Staudacher, D. L. | Sci Rep | 2021 |
Acute Kidney Injury/*diagnosis/epidemiology |
| Advantages of score-based delirium detection compared to a clinical delirium assessment-a retrospective, monocentric cohort study | Jäckel, M. Aicher, N. Bemtgen, X. Rilinger, J. Zotzmann, V. Biever, P. M. Supady, A. Stachon, P. Duerschmied, D. Wengenmayer, T. Bode, C. Staudacher, D. L. | PLoS One | 2021 |
score-based delirium detection clinical delirium monocentric cohort study |
| A Comparison of Dexmedetomidine and Propofol on Emergence Delirium in Children Undergoing Cleft Palate Surgery With Sevoflurane-Based Anesthesia | Huang, L. Wang, L. Peng, W. Qin, C. | J Craniofac Surg | 2021 |
Emergence Delirium Children Cleft Palate Surgery Sevoflurane |
| Automated machine learning-based model predicts postoperative delirium using readily extractable perioperative collected electronic data | Hu, X. Y. Liu, H. Zhao, X. Sun, X. Zhou, J. Gao, X. Guan, H. L. Zhou, Y. Zhao, Q. Han, Y. Cao, J. L. | CNS Neurosci Ther | 2021 |
delirium |
| Feasibility of low-dose dexmedetomidine for prevention of postoperative delirium after intracranial operations: a pilot randomized controlled trial | He, X. Cheng, K. M. Duan, Y. Q. Xu, S. S. Gao, H. R. Miao, M. Y. Li, H. L. Chen, K. Yang, Y. L. Zhang, L. Gu, H. Q. Zhou, J. X. | BMC Neurol | 2021 |
Delirium |
| Reliability and validity of the Japanese version of the 4A's Test for delirium screening in the elderly patient | Hasegawa, T. Seo, T. Kubota, Y. Sudo, T. Yokota, K. Miyazaki, N. Muranaka, A. Hirano, S. Yamauchi, A. Nagashima, K. Iyo, M. Sakai, I. | Asian J Psychiatr | 2021 |
Attention |
| Neural autoantibodies in delirium | Hansen, N. Krasiuk, I. Titsch, T. | J Autoimmun | 2021 |
Cognitive dysfunction |
| Risk Factors for Delirium in the Palliative Care Population: A Systematic Review and Meta-Analysis | Guo, D. Lin, T. Deng, C. Zheng, Y. Gao, L. Yue, J. | Front Psychiatry | 2021 |
delirium |
| Incidence, risk factors, and consequences of emergence delirium after elective brain tumor resection | Gu, W. J. Zhou, J. X. Ji, R. Q. Zhou, L. Y. Wang, C. M. | Surgeon | 2021 |
Emergence delirium |
| A scientometric study of publications on delirium from 2001 to 2020 | Grover, S. Gupta, B. M | Asian J Psychiatr | 2021 |
Aged |
| The neuropsychological profile of delirium vulnerability: A systematic review and meta-analysis | Ghezzi, E. S. Ross, T. J. Sharman, R. Davis, D. Boord, M. S. Thanabalan, T. Thomas, J. Keage, H. A. D. | Neurosci Biobehav Rev | 2021 |
ageing |
| Cognitive Functionality of Patients with Delirium after Stroke | Dostović, Z. Ibrahimagić, OĆ Smajlović, D. Kunić, S. Čustović, A. | Psychiatr Danub | 2021 |
Cognition |
| Sleep quality and emergence delirium in children undergoing strabismus surgery: a comparison between preschool- and school-age patients | Do, W. Kim, H. S. Kim, S. H. Kang, H. Lee, D. Baik, J. Lee, H. J. Hong, J. M. | BMC Anesthesiol | 2021 |
*Emergence delirium |
| Multicomponent nursing program to prevent delirium in critically ill patients: a randomized clinical trial | Contreras, C. C. T. Esteban, A. N. P. Parra, M. D. Romero, M. K. R. Silva, C. G. D. Buitrago, N. P. D. | Rev Gaucha Enferm | 2021 |
*Critical Illness |
| Longitudinal validation of an electronic health record delirium prediction model applied at admission in COVID-19 patients | Castro, V. M. Hart, K. L. Sacks, C. A. Murphy, S. N. Perlis, R. H. McCoy, T. H., Jr. | Gen Hosp Psychiatry | 2021 |
Covid-19 |
| Independent, Differential Effects of Delirium on Disability and Mortality Risk After Hip Fracture | Cartei, A. Mossello, E. Ceccofiglio, A. Rubbieri, G. Polidori, G. Ranalli, C. Cammilli, A. Curcio, M. Cavallini, M. C. Mannarino, G. M. Ungar, A. Toccafondi, G. Peris, A. Marchionni, N. Rostagno, C. | J Am Med Dir Assoc | 2021 |
Delirium |
| Melatonin and melatonin-receptor agonists to prevent delirium in hospitalized older adults: An umbrella review | Blodgett, T. J. Blodgett, N. P. | Geriatr Nurs | 2021 |
Circadian Rhythm |
| Barriers to completing the 4AT for delirium and its clinical implementation in two hospitals: a mixed-methods study | Alhaidari, A. A. O. Matsis, K. P. | Eur Geriatr Med | 2021 |
Delirium |
| The relationship between sensory stimuli and the physical environment in complex healthcare settings: A systematic literature review | Bayramzadeh, S. Ahmadpour, S. Aghaei, P. | Intensive Crit Care Nurs | 2021 |
*Communication |
| Simultaneous bilateral total knee arthroplasty is safe and effective for patients in different ages | Ariga, A. Kohno, Y. Nakagawa, Y. Watanabe, T. Katagiri, H. Ohara, T. Shioda, M. Ozeki, N. Amemiya, M. Okawa, A. Sekiya, I. Koga, H. | J Orthop Sci | 2021 |
Age groups |
| Machine Learning Algorithm Using Electronic Chart-Derived Data to Predict Delirium After Elderly Hip Fracture Surgeries: A Retrospective Case-Control Study | Zhao, H. You, J. Peng, Y. Feng, Y. | Front Surg | 2021 |
delirium |
| The Effect of Data Length on the Assessment of Dynamic Cerebral Autoregulation with Transfer Function Analysis in Neurological ICU Patients | Zhang, W. Lu, H. Zhang, P. Mo, X. Ou, A. Liu, J. Zhong, J. | Neurocrit Care | 2021 |
Data length |
| Clinical Features and Outcomes of Neuropsychiatric Systemic Lupus Erythematosus in China | Zhang, S. Li, M. Zhang, L. Wang, Z. Wang, Q. You, H. Wang, Y. Li, M. Zeng, X. | J Immunol Res | 2021 |
Adult |
| Noncontact Monitoring of Heart Rate and Heart Rate Variability in Geriatric Patients Using Photoplethysmography Imaging | Yu, X. Laurentius, T. Bollheimer, C. Leonhardt, S. Antink, C. H. | IEEE J Biomed Health Inform | 2021 |
Aged |
| Non-Contact Measurement of Heart Rate Variability in Frail Geriatric Patients: Response to Early Geriatric Rehabilitation and Comparison with Healthy Old Community-Dwelling Individuals - A Pilot Study | Yu, X. Hoog Antink, C. Leonhardt, S. Bollheimer, L. C. Laurentius, T. | Gerontology | 2021 |
Frailty |
| Aggressive patient behaviours and unplanned nursing staff leave - is there an association? | Yu, J. J. Holbeach, E. | Int J Ment Health Nurs | 2021 |
Aggression |
| The Significant Prognostic Factors in Prolonged Intensive/High Care Unit Stay After Living Donor Liver Transplantation | Yoshiya, S. Harada, N. Tomiyama, T. Takeishi, K. Toshima, T. Iguchi, T. Itoh, S. Ninomiya, M. Yoshizumi, T. Mori, M. | Transplant Proc | 2021 |
Adult |
| Mode displaying mouse cursors for reducing input language mode confusion: Utility and user attitude evaluation | Yoo, T. Lee, H. Hyun, S. Park, W. | Appl Ergon | 2021 |
Confusion |
| Incidence and influencing factors of post-intensive care cognitive impairment | Yao, L. Li, Y. Yin, R. Yang, L. Ding, N. Li, B. Shen, X. Zhang, Z. | Intensive Crit Care Nurs | 2021 |
Apache |
| Validation of the Simplified Palliative Prognostic Index to Predict Survival for Advanced Cancer Patients in Home Hospice Setting | Yang, H. J. Yoon, S. J. Kim, J. S. Kim, S. S. Jung, J. G. Suh, W. Y. Lee, S. Kim, H. G. Lee, Y. W. | Korean J Fam Med | 2021 |
Hospice Care |
| Oral corticosteroid dosage and clinical presentation of psychiatric conditions after steroid use: A consultation-liaison psychiatry service's experience | Yagi, Y. Takahashi, Y. Ogata, Y. Yamana, H. Kumakura, Y. Ichihashi, K. Kasai, K. Kondo, S. | Neuropsychopharmacol Rep | 2021 |
consultation-liaison psychiatry |
| Machine learning-assisted screening for cognitive impairment in the emergency department | Yadgir, S. R. Engstrom, C. Jacobsohn, G. C. Green, R. K. Jones, C. M. C. Cushman, J. T. Caprio, T. V. Kind, A. J. H. Lohmeier, M. Shah, M. N. Patterson, B. W. | J Am Geriatr Soc | 2021 |
cognitive impairment |
| Effects of perioperative rosuvastatin on postoperative delirium in elderly patients: A randomized, double-blind, and placebo-controlled trial | Xu, X. Q. Luo, J. Z. Li, X. Y. Tang, H. Q. Lu, W. H. | World J Clin Cases | 2021 |
Elderly |
| Is Perioperative Dexmedetomidine Associated With a Reduced Risk of Perioperative Neurocognitive Disorders Following Cardiac Surgery? A Systematic Review and Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials | Xiong, X. Chen, D. Shi, J. | Front Med (Lausanne) | 2021 |
cardiac surgery |
| The effect of pre-operative methylprednisolone on postoperative delirium in elderly patients undergoing gastrointestinal surgery: a randomized, double-blind, placebo-controlled trial | Xiang, X. B. Chen, H. Wu, Y. L. Wang, K. Yue, X. Cheng, X. Q. | J Gerontol A Biol Sci Med Sci | 2021 |
Delirium |
| Social Determinants of Health and Delirium Occurrence and Duration in Critically Ill Adults | Wu, T. T. Zegers, M. Kooken, R. Griffith, J. L. Molnar, B. E. Devlin, J. W. van den Boogaard, M. | Crit Care Explor | 2021 |
delirium |
| Implementation of a Frailty Assessment and Targeted Care Interventions and Its Association with Reduced Postoperative Complications in Elderly Surgical Patients | Wilson, S. Sutherland, E. Razak, A. O'Brien, M. Ding, C. Nguyen, T. Rosenkranz, P. Sanchez, S. E. | J Am Coll Surg | 2021 |
Frailty, Postoperative outcomes, Geriatrics, Frailty assessment |
| Prevalence of Mimics and Severe Comorbidity in Patients with Clinically Suspected Transient Global Amnesia | Werner, R. Woehrle, J. C. | Cerebrovasc Dis | 2021 |
Adult |
| The risk of delirium and falls or fractures with the use of overactive bladder anticholinergic medications | Welk, B. Etaby, K. McArthur, E. Chou, Q. | Neurourol Urodyn | 2021 |
anticholinergics |
| Hospitalization Outcomes of Delirium in Patients Admitted to Acute Care Hospitals in Their Last Year of Life: A Population-Based Retrospective Cohort Study | Webber, C. Watt, C. L. Bush, S. H. Lawlor, P. G. Talarico, R. Tanuseputro, P. | J Pain Symptom Manage | 2021 |
Adult |
| Anticholinergics and clinical outcomes amongst people with pre-existing dementia: A systematic review | Wang, K. Alan, J. Page, A. T. Dimopoulos, E. Etherton-Beer, C. | Maturitas | 2021 |
Anticholinergic |
| Association Between Intraoperative Arterial Hypotension and Postoperative Delirium After Noncardiac Surgery: A Retrospective Multicenter Cohort Study | Wachtendorf, L. J. Azimaraghi, O. Santer, P. Linhardt, F. C. Blank, M. Suleiman, A. Ahn, C. Low, Y. H. Teja, B. Kendale, S. M. Schaefer, M. S. Houle, T. T. Pollard, R. J. Subramaniam, B. Eikermann, M. Wongtangman, K. | Anesth Analg | 2021 |
Intraoperative Arterial Hypotension, Postoperative delirium, Surgery, Anesthesia |
| Dynamic assessments of hepatic encephalopathy and ammonia levels predict mortality in acute-on-chronic liver failure | Verma, N. Dhiman, R. K. Choudhury, A. Taneja, S. Duseja, A. Singh, V. Al Mahtab, M. Devarbhavi, H. Shukla, A. Ning, Q. Hamid, S. S. Butt, A. S. Jafri, W. Tan, S. S. Hu, J. Zhongping, D. Treeprasertsuk, S. Lee, G. H. Ghazinyan, H. Lesmana, L. A. Sood, A. M | Hepatol Int | 2021 |
*Acute-On-Chronic Liver Failure |
| Evaluation of the impact of cataract surgery on cognitive function in very elderly patients: a prospective, observational study | Verdina, T. Stiro, F. Bruni, F. Spedicato, G. A. Mastropasqua, R. Cavallini, G. M. | Aging Clin Exp Res | 2021 |
6-item cognitive impairment test (6CIT) |
| Physiological Assessment of Delirium Severity: The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S) | van Sleuwen, M. Sun, H. Eckhardt, C. Neelagiri, A. Tesh, R. A. Westmeijer, M. Paixao, L. Rajan, S. Velpula Krishnamurthy, P. Sikka, P. Leone, M. J. Panneerselvam, E. Quadri, S. A. Akeju, O. Kimchi, E. Y. Westover, M. B. | Crit Care Med | 2021 |
van Sleuwen, M. |
| The effect of peri-operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non-cardiac surgical patients: a randomised, double-blind placebo-controlled trial | van Norden, J. Spies, C. D. Borchers, F. Mertens, M. Kurth, J. Heidgen, J. Pohrt, A. Mueller, A. | Anaesthesia | 2021 |
Aged |
| Rivastigmine for minor visual hallucinations in Parkinson's disease: A randomized controlled trial with 24 months follow-up | van Mierlo, T. J. M. Foncke, E. M. J. Post, B. Schmand, B. A. Bloem, B. R. van Harten, B. Tissingh, G. Munts, A. G. de Haan, R. J. de Bie, R. M. A. | Brain Behav | 2021 |
Cholinesterase Inhibitors |
| Effects of Orthogeriatric Care Models on Outcomes of Hip Fracture Patients: A Systematic Review and Meta-Analysis | Van Heghe, A. Mordant, G. Dupont, J. Dejaeger, M. Laurent, M. R. Gielen, E. | Calcif Tissue Int | 2021 |
Geriatric co-management |
| Automatic continuous EEG signal analysis for diagnosis of delirium in patients with sepsis | Urdanibia-Centelles, O. Nielsen, R. M. Rostrup, E. Vedel-Larsen, E. Thomsen, K. Nikolic, M. Johnsen, B. Møller, K. Lauritzen, M. Benedek, K. | Clin Neurophysiol | 2021 |
Automatic EEG |
| Evaluation of the effectiveness of delirium prevention care protocol for the patients with hip fracture: A randomised controlled study | Unal, N. Guvenc, G. Ilkin Naharci, M. | J Clin Nurs | 2021 |
nursing care |
| Association of poor sleep burden in middle age and older adults with risk for delirium during hospitalization | Ulsa, M. C. Zheng, X. Li, P. Gaba, A. Wong, P. M. Saxena, R. Scheer, F. Rutter, M. Akeju, O. Hu, K. Gao, L. | J Gerontol A Biol Sci Med Sci | 2021 |
Sleep health |
| Where should patients with or at risk of delirium be treated in an acute care system? Comparing the rates of delirium in patients receiving usual care vs alternative care: A systematic review and meta-analysis | Ukwuoma Ekeozor, C. Jeyaruban, D. Lasserson, D. | Int J Clin Pract | 2021 |
Critical Care |
| Restraint use in the acute-care hospital setting: A cross-sectional multi-centre study | Thomann, S. Zwakhalen, S. Richter, D. Bauer, S. Hahn, S. | Int J Nurs Stud | 2021 |
Cross-Sectional Studies |
| Immune, Blood Cell, and Blood Gas Biomarkers of Delirium in Elderly Individuals with Hip Fracture Surgery | Thisayakorn, P. Tangwongchai, S. Tantavisut, S. Thipakorn, Y. Sukhanonsawat, S. Wongwarawipat, T. Sirivichayakul, S. Maes, M. | Dement Geriatr Cogn Disord | 2021 |
Delirium |
| Delirium Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS) | Teng, C. Frei, C. R. | Drugs Real World Outcomes | 2021 |
Delirium, Antibiotics, FDA Adverse Event Reporting System |
| The Impact of Aging on Symptom Prevalence and Management in Terminally ill Patients With Cancer | Tatokoro, M. Matsuo, N. | J Pain Symptom Manage | 2021 |
Age |
| Subjective strain of care experienced by pulmonary and critical care medical nurses when caring for patients with delirium: a cross-sectional study | Tan, H. Zhou, L. Wu, S. Dong, Q. Yang, L. Xu, J. Zhao, S. Wang, X. Yang, H. | BMC Health Serv Res | 2021 |
Critical Care |
| Circulating MicroRNAs and Novel Proteins as Potential Biomarkers of Neurological Complications after Heart Bypass Surgery | Szwed, K. Szwed, M. Kozakiewicz, M. Karłowska-Pik, J. Soja-Kukieła, N. Bartoszewska, A. Borkowska, A. | J Clin Med | 2021 |
Cabg |
| Evaluation of the implementation of multidisciplinary fast-track program for acute geriatric hip fractures at a University Hospital in resource-limited settings | Sura-Amonrattana, U. Tharmviboonsri, T. Unnanuntana, A. Tantigate, D. Srinonprasert, V. | BMC Geriatr | 2021 |
Aged |
| Perceptions of current occupational therapy practice with older adults experiencing delirium | Strecker, C. Hitch, D. | Australas J Ageing | 2021 |
Aged |
| Changes in autonomic tone during delirium in acute stroke patients assessed by pupillometry and skin conductance | Stokholm, J. Birkmose, L. K. H. Ahmed, Aabo Csillag, C. Kjær, T. W. Christensen, T. | J Neurol Sci | 2021 |
Autonomic Nervous System |
| Expression of HO1 and PER2 can predict the incidence of delirium in trauma patients with concomitant brain injury | Steimer, M. Kaiser, S. Ulbrich, F. Kalbhenn, J. Bürkle, H. Schallner, N. | Sci Rep | 2021 |
Biomarkers, Circadian rhythms and sleep, Translational research, Neurological manifestations |
| An implementation science approach to geriatric screening in an emergency department | Southerland, L. T. Hunold, K. M. Van Fossen, J. Caterino, J. M. Gulker, P. Stephens, J. A. Bischof, J. J. Farrell, E. Carpenter, C. R. Mion, L. C. | J Am Geriatr Soc | 2021 |
Cfir |
| Effectiveness of the ABCDEF bundle on delirium, functional outcomes and quality of life in intensive care patients: a study protocol for a randomised controlled trial with embedded process evaluation | Sosnowski, K. Mitchell, M. Cooke, M. White, H. Morrison, L. Lin, F. | BMJ Open | 2021 |
Critical Care |
| Effects of general versus subarachnoid anaesthesia on circadian melatonin rhythm and postoperative delirium in elderly patients undergoing hip fracture surgery: A prospective cohort clinical trial | Song, Y. Liu, Y. Yuan, Y. Jia, X. Zhang, W. Wang, G. Jia, Y. Wang, X. Liu, L. Li, W. Li, X. Cai, N. Liu, C. Li, Y. Han, Y. Zhou, Y. Mi, X. Shi, C. Wang, J. Q. Vuylsteke, A. Guo, X. Li, Z. | EBioMedicine | 2021 |
Circadian rhythm |
| Comparison of the Effects of Haloperidol and Dexmedetomidine on Delirium and Agitation in Patients with a Traumatic Brain Injury Admitted to the Intensive Care Unit | Soltani, F. Tabatabaei, S. Jannatmakan, F. Nasajian, N. Amiri, F. Darkhor, R. Moravej, M. | Anesth Pain Med | 2021 |
Delirium |
| Comparison of postoperative delirium within 24 hours between ketamine and propofol infusion during cardiopulmonary bypass machine: A randomized controlled trial | Siripoonyothai, S. Sindhvananda, W. | Ann Card Anaesth | 2021 |
*Cardiac surgery |
| Improving delirium detection in intensive care units: Multicomponent education and training program | Sinvani, L. Delle Site, C. Laumenede, T. Patel, V. Ardito, S. Ilyas, A. Hertz, C. Wolf-Klein, G. Pekmezaris, R. Hajizadeh, N. Thomas, L. | J Am Geriatr Soc | 2021 |
critical care nursing |
| Outcome, demography and resource utilization in ICU Patients with delirium and malignancy | Sieber, M. Rudiger, A. Schüpbach, R. Krüger, B. Schubert, M. Bettex, D. | Sci Rep | 2021 |
Medical research, Oncology, Delirium, ICU delirium, ICDSC, Malignancies |
| Prevalence of postoperative delirium with different combinations of intraoperative general anesthetic agents in patients undergoing cardiac surgery: A retrospective propensity-score-matched study | Shin, H. J. Choi, S. L. Na, H. S. | Medicine (Baltimore) | 2021 |
Aged |
| Is Comprehensive Geriatric Assessment Admission Avoidance Hospital at Home an Alternative to Hospital Admission for Older Persons? : A Randomized Trial | Shepperd, S. Butler, C. Cradduck-Bamford, A. Ellis, G. Gray, A. Hemsley, A. Khanna, P. Langhorne, P. Mort, S. Ramsay, S. Schiff, R. Stott, D. J. Wilkinson, A. Yu, L. M. Young, J. | Ann Intern Med | 2021 |
Aged |
| Delirium and abnormal autonomic nervous system response to head-up tilt testing | Shanahan, E. Ryan, S. Leahy, A. Sheehy, T. Costelloe, A. Roy, A. Galvin, R. Peters, C. Lyons, D. O'Connor, M. | Exp Gerontol | 2021 |
Aged, 80 and over |
| Understanding frailty among older people living in old age homes and the community in Nepal: A cross-sectional study | Shah, R. Carandang, R. R. Shibanuma, A. Ong, K. I. C. Kiriya, J. Jimba, M. | PLoS One | 2021 |
Activities of Daily Living |
| Death in delirious palliative-care patients occurs irrespective of age: A prospective, observational cohort study of 229 delirious palliative-care patients | Seiler, A. Blum, D. Hertler, C. Schettle, M. Zipser, C. M. Bode, L. Gehrke, S. Ernst, J. Schubert, M. von Känel, R. Boettger, S. | Palliat Support Care | 2021 |
Aged |
| Delirium Variability is Influenced by the Sound Environment (DEVISE Study): How Changes in the Intensive Care Unit soundscape affect delirium incidence | Sangari, A. Emhardt, E. A. Salas, B. Avery, A. Freundlich, R. E. Fabbri, D. Shotwell, M. S. Schlesinger, J. J. | J Med Syst | 2021 |
Critical Care |
| Delirium in Intensive Care Units: Perceptions of Physicians and Nurses | Salameh, B. Al Razeeni, D. M. Mansor, K. Abdallah, J. M. Ayed, A. Salem, H. | Crit Care Nurs Q | 2021 |
Critical Care |
| How to deal with the consent of adults with cognitive impairment involved in European geriatric living labs? | Sacco, G. Noublanche, F. Blazek, F. Hue, C. Carballido, L. Asfar, M. Allain, P. Annweiler, C. | Philos Ethics Humanit Med | 2021 |
Aged |
| Management of preoperative pain in elderly patients with moderate to severe cognitive deficits and hip fracture: a retrospective, monocentric study in an orthogeriatric unit | Ruel, M. Boussat, B. Boudissa, M. Garnier, V. Bioteau, C. Tonetti, J. Pailhe, R. Gavazzi, G. Drevet, S. | BMC Geriatr | 2021 |
Aged |
| Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial | Rozemeijer, S. de Grooth, H. J. Elbers, P. W. G. Girbes, A. R. J. den Uil, C. A. Dubois, E. A. Wils, E. J. Rettig, T. C. D. van Zanten, A. R. H. Vink, R. van den Bogaard, B. Bosman, R. J. Oudemans-van Straaten, H. M. de Man, A. M. E. | Trials | 2021 |
Ascorbic Acid |
| Synergistic Impact of Systolic Blood Pressure and Perfusion Status on Mortality in Acute Heart Failure | Rossello, X. Bueno, H. Gil, V. Jacob, J. Martín-Sánchez, F. J. Llorens, P. Herrero Puente, P. Alquézar-Arbé, A. Espinosa, B. Raposeiras-Roubín, S. Müller, C. E. Mebazaa, A. Maggioni, A. P. Pocock, S. Chioncel, O. Miró, Ò | Circ Heart Fail | 2021 |
Acute Disease |
| The Impact of Nursing Delirium Preventive Interventions in the ICU: A Multicenter Cluster-randomized Controlled Clinical Trial | Rood, P. J. T. Zegers, M. Ramnarain, D. Koopmans, M. Klarenbeek, T. Ewalds, E. van der Steen, M. S. Oldenbeuving, A. W. Kuiper, M. A. Teerenstra, S. Adang, E. van Loon, L. M. Wassenaar, A. Vermeulen, H. Pickkers, P. van den Boogaard, M. | Am J Respir Crit Care Med | 2021 |
Aged |
| Heart rate variability and delirium in acute non-cardioembolic stroke: a prospective, cross-sectional, cohort study | Rollo, E. Marotta, J. Callea, A. Brunetti, V. Vollono, C. Scala, I. Imperatori, C. Frisullo, G. Broccolini, A. Della Marca, G. | Neurol Sci | 2021 |
Autonomic |
| The training needs of Korean intensive care unit nurses regarding delirium | Roh, Y. S. | Intensive Crit Care Nurs | 2021 |
Clinical Competence |
| Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people-results from a nested, longitudinal cohort study | Richardson, S. J. Lawson, R. Davis, D. H. J. Stephan, B. C. M. Robinson, L. Matthews, F. E. Brayne, C. Barnes, L. E. Taylor, J. P. Parker, S. G. Allan, L. M. | Age Ageing | 2021 |
Aged |
| Recurrent delirium over 12 months predicts dementia: results of the Delirium and Cognitive Impact in Dementia (DECIDE) study | Richardson, S. J. Davis, D. H. J. Stephan, B. C. M. Robinson, L. Brayne, C. Barnes, L. E. Taylor, J. P. Parker, S. G. Allan, L. M. | Age Ageing | 2021 |
Cognition |
| Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated With Postoperative Delirium | Rhee, J. Kuznetsov, A. McKay, T. Lyons, M. Houstis, N. Mekkonen, J. Ethridge, B. Ibala, R. Hahm, E. Gitlin, J. Guseh, J. S. Kitchen, R. Rosenzweig, A. Shaefi, S. Flaczyk, A. Qu, J. Akeju, O. | Front Aging Neurosci | 2021 |
*il-6 |
| Comparison of Esophagectomy outcomes between a National Center, a National Audit Collaborative, and an International database using the Esophageal Complications Consensus Group (ECCG) standardized definitions | Reynolds, J. V. Donlon, N. Elliott, J. A. Donohoe, C. Ravi, N. Kuppusamy, M. K. Low, D. E. | Dis Esophagus | 2021 |
Aged |
| Health Profiles, Health Services Use, and Transition to Dementia in Inpatients With Late-Life Depression and Other Mental Illnesses | Reppermund, S. Heintze, T. Srasuebkul, P. Trollor, J. N. | J Am Med Dir Assoc | 2021 |
Aged |
| A Survey of Nurses' Perspectives on Delirium Screening in Older Adult Medical Inpatients With Limited English Proficiency | Reppas-Rindlisbacher, C. Panov, E. D. Cuperfain, A. B. Rawal, S. | J Gerontol Nurs | 2021 |
Aged |
| Post-hospital falls incidence and risk factors among older adults: a systematic review and meta-analysis | Qian, X. X. Chen, Z. Fong, D. Y. T. Ho, M. Chau, P. H. | Age Ageing | 2021 |
incidence |
| The prevalence of serotonin syndrome in an intensive care unit: A prospective observational study | Prakash, S. Rathore, C. Rana, K. | J Crit Care | 2021 |
Adult |
| Associations of subclinical heart failure and atrial fibrillation with mild cognitive impairment: a cross-sectional study in a subclinical heart failure screening programme | Potter, E. L. Ramkumar, S. Wright, L. Marwick, T. H. | BMJ Open | 2021 |
Aged |
| A One-Day Prospective National Observational Study on Sedation-Analgesia of Patients with Brain Injury in French Intensive Care Units: The SEDA-BIP-ICU (Sedation-Analgesia in Brain Injury Patient in ICU) Study | Poignant, S. Vigué, B. Balram, P. Biais, M. Carillon, R. Cottenceau, V. Dahyot-Fizelier, C. Degos, V. Geeraerts, T. Jeanjean, P. Vega, E. Lasocki, S. Espitalier, F. Laffon, M. | Neurocrit Care | 2021 |
Brain injury |
| Risk factors and adverse clinical outcomes of postoperative delirium in Thai elderly patients: A prospective cohort study | Pipanmekaporn, T. Punjasawadwong, Y. Wongpakaran, N. Wongpakaran, T. Suwannachai, K. Chittawatanarat, K. Mueankwan, S. | Perspect Psychiatr Care | 2021 |
Aged |
| Multifaceted intervention including Facebook-groups to improve guideline-adherence in ICU: A quasi-experimental interrupted time series study | Petosic, A. Småstuen, M. C. Beeckman, D. Flaatten, H. Sunde, K. Wøien, H. | Acta Anaesthesiol Scand | 2021 |
agitation/sedation |
| Perioperative Optimization of Senior Health in Spine Surgery: Impact on Postoperative Delirium | Pernik, M. N. Deme, P. R. Nguyen, M. L. Aoun, S. G. Adogwa, O. Hall, K. Stewart, N. A. Dosselman, L. J. El Tecle, N. E. McDonald, S. R. Bagley, C. A. Wingfield, S. A. | J Am Geriatr Soc | 2021 |
Aged |
| Postoperative delirium mediates 180-day mortality in orthopaedic trauma patients | Pedemonte, J. C. Sun, H. Franco-Garcia, E. Zhou, C. Heng, M. Quraishi, S. A. Westover, B. Akeju, O. | Br J Anaesth | 2021 |
Aged |