What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- The LiberAction Project: Implementation of a Pediatric Liberation Bundle to Screen Delirium, Reduce Benzodiazepine Sedation, and Provide Early Mobilization in a Human Resource-Limited Pediatric Intensive Care Unit
- Authors
- Di Nardo, M. Boldrini, F. Broccati, F. Cancani, F. Satta, T. Stoppa, F. Genuini, L. Zampini, G. Perdichizzi, S. Bottari, G. Fischer, M. Gawronski, O. Bonetti, A. Piermarini, I. Recchiuti, V. Leone, P. Rossi, A. Tabarini, P. Biasucci, D. Villani, A. Raponi
- Year
- 2021
- Journal
- Front Pediatr
- Abstract
Background: Delirium, bed immobilization, and heavy sedation are among the major contributors of pediatric post-intensive care syndrome. Recently, the Society of Critical Care Medicine has proposed the implementation of daily interventions to minimize the incidence of these morbidities and optimize children functional outcomes and quality of life. Unfortunately, these interventions require important clinical and economical efforts which prevent their use in many pediatric intensive care units (PICU). Aim: First, to evaluate the feasibility and safety of a PICU bundle implementation prioritizing delirium screening and treatment, early mobilization (<72 h from PICU admission) and benzodiazepine-limited sedation in a human resource-limited PICU. Second, to evaluate the incidence of delirium and describe the early mobilization practices and sedative drugs used during the pre- and post-implementation periods. Third, to describe the barriers and adverse events encountered during early mobilization. Methods: This observational study was structured in a pre- (15th November 2019-30th June 2020) and post-implementation period (1st July 2020-31st December 2020). All patients admitted in PICU for more than 72 h during the pre and post-implementation period were included in the study. Patients were excluded if early mobilization was contraindicated. During the pre-implementation period, a rehabilitation program including delirium screening and treatment, early mobilization and benzodiazepine-sparing sedation guidelines was developed and all PICU staff trained. During the post-implementation period, delirium screening with the Connell Assessment of Pediatric Delirium scale was implemented at bedside. Early mobilization was performed using a structured tiered protocol and a new sedation protocol, limiting the use of benzodiazepine, was adopted. Results: Two hundred and twenty-five children were enrolled in the study, 137 in the pre-implementation period and 88 in the post-implementation period. Adherence to delirium screening, benzodiazepine-limited sedation and early mobilization was 90.9, 81.1, and 70.4%, respectively. Incidence of delirium was 23% in the post-implementation period. The median cumulative dose of benzodiazepines corrected for the total number of sedation days (mg/kg/sedation days) was significantly lower in the post-implementation period compared with the pre-implementation period: [0.83 (IQR: 0.53-1.31) vs. 0.74 (IQR: 0.55-1.16), p = 0.0001]. The median cumulative doses of fentanyl, remifentanil, and morphine corrected for the total number of sedation days were lower in the post-implementation period, but these differences were not significant. The median number of mobilizations per patient and the duration of each mobilization significantly increased in the post-implementation period [3.00 (IQR: 2.0-4.0) vs. 7.00 (IQR: 3.0-12.0); p = 0.004 and 4 min (IQR: 3.50-4.50) vs. 5.50 min (IQR: 5.25-6.5); p < 0.0001, respectively]. Barriers to early mobilization were: disease severity and bed rest orders (55%), lack of physicians’ order (20%), lack of human resources (20%), and lack of adequate devices for patient mobilization (5%). No adverse events related to early mobilization were reported in both periods. Duration of mechanical ventilation and PICU length of stay was significantly lower in the post-implementation period as well as the occurrence of iatrogenic withdrawal syndrome. Conclusion: This study showed that the implementation of a PICU liberation bundle prioritizing delirium screening and treatment, benzodiazepine-limited sedation and early mobilization was feasible and safe even in a human resource-limited PICU. Further pediatric studies are needed to evaluate the clinical impact of delirium, benzodiazepine-limited sedation and early mobilization protocols on patients’ long-term functional outcomes and on hospital finances.
- PMID
- Keywords
benzodiazepine (BDZ)
bundle
delirium
early mobilization
pediatric intensive care
sedation
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Early Diagnosis of Delirium in Palliative Care Patients Decreases Mortality and Necessity of Palliative Sedation: Results of a Prospective Observational Study | Beretta, M. Uggeri, S. Santucci, C. Cattaneo, M. Ermolli, D. Gerosa, C. Ornaghi, M. Roccasalva, A. Santambrogio, P. Varrassi, G. Corli, O. | Cureus | 2022 |
clinical outcome |
| Incidence and associations of hospital delirium diagnoses in 85,979 people with severe mental illness: A data linkage study | Bauernfreund, Y. Launders, N. Favarato, G. Hayes, J. F. Osborn, D. Sampson, E. L. | Acta Psychiatr Scand | 2022 |
bipolar disorder |
| The Pharmacogenetics of Opiates and Its Impact on Delirium in Mechanically Ventilated Adults: A Pilot Study | Austin, C. A. Szeto, A. Gupta, A. Wiltshire, T. Crona, D. J. Kistler, C. | J Pharm Technol | 2022 |
analgesics |
| Agents intervening against delirium in the intensive care unit trial-Protocol for a secondary Bayesian analysis | Andersen-Ranberg, N. Poulsen, L. M. Perner, A. Hästbacka, J. Morgan, M. P. G. Citerio, G. Oxenbøll-Collet, M. Weber, S. O. Andreasen, A. S. Bestle, M. H. Uslu, B. Pedersen, H. B. S. Nielsen, L. G. Damgaard, K. Jensen, T. B. Sommer, T. Dey, N. Mathiesen, | Acta Anaesthesiol Scand | 2022 |
Adult |
| Increased Direct Current-Electroencephalography Shifts During Induction of Anesthesia in Elderly Patients Developing Postoperative Delirium | Windmann, V. Dreier, J. P. Major, S. Spies, C. Lachmann, G. Koch, S. | Front Aging Neurosci | 2022 |
*dc-eeg |
| The Effect of Propofol versus Sevoflurane on Postoperative Delirium in Parkinson's Disease Patients Undergoing Deep Brain Stimulation Surgery: An Observational Study | Zhou, Y. Li, Z. Ma, Y. Yu, C. Chen, Y. Ding, J. Yu, J. Zhou, R. Wang, X. Liu, T. Guo, X. Fan, T. Shi, C. | Brain Sci | 2022 |
Parkinson’s disease |
| Association between smoking and postoperative delirium in surgical patients with pulmonary hypertension: a secondary analysis of a cohort study | Zhou, S. Shi, S. Xie, C. Chen, G. | BMC Psychiatry | 2022 |
Cohort Studies |
| Comorbidity patterns in institutionalized older adults affected by dementia | Zazzara, M. B. Vetrano, D. L. Carfì, A. Liperoti, R. Damiano, C. Onder, G. | Alzheimers Dement (Amst) | 2022 |
care pathways |
| The Impact of Perioperative and Predisposing Risk Factors on the Development of Postoperative Delirium and a Possible Gender Difference | Wittmann, M. Kirfel, A. Jossen, D. Mayr, A. Menzenbach, J. | Geriatrics (Basel) | 2022 |
gender difference |
| Four-in-One: A Comprehensive Checklist for the Assessment of Pain, Undersedation, Iatrogenic Withdrawal and Delirium in the PICU: A Delphi Study | van Dijk, M. Ista, E. | Front Pediatr | 2022 |
Iws |
| Analgesia, Sedation, Paralytics, Delirium, and Iatrogenic Withdrawal | Valentine, K. Kummick, J. | Pediatr Clin North Am | 2022 |
*Analgesia |
| Antipsychotic prescribing in people admitted to hospital with dementia or delirium | Tumusiime, W. A. Hardman, C. J. Breen, J. L. | Australas J Ageing | 2022 |
*Antipsychotic Agents/therapeutic use |
| Breaking barriers in postoperative delirium | Terrando, N. Akassoglou, K. | Br J Anaesth | 2022 |
biomarker |
| The Relationship Between Suboptimal Social Networks and Postoperative Delirium: The PNDABLE Study | Tang, X. Yv, H. Wang, F. Wang, J. Liu, S. Wu, X. Dong, R. Lin, X. Wang, B. Bi, Y. | Front Aging Neurosci | 2022 |
cerebrospinal fluid |
| Delirium incidence and risk factors in patients undergoing non-invasive ventilation for acute respiratory failure: a multicenter observational trial | Tabbì, L. Tonelli, R. Comellini, V. Dongilli, R. Sorgentone, S. Spacone, A. Paonessa, M. C. Sacchi, M. Falsini, L. Boni, E. Ribuffo, V. Bruzzi, G. Castaniere, I. Fantini, R. Marchioni, A. Pisani, L. Nava, S. Clini, E. | Minerva Anestesiol | 2022 | |
| The association between Monocyte-to-Lymphocyte ratio and postoperative delirium in ICU patients in cardiac surgery | Su, X. Wang, J. Lu, X. | J Clin Lab Anal | 2022 |
inflammatory markers |
| Development of a non-pharmacologic delirium management bundle in paediatric intensive care units | Stenkjaer, R. L. Herling, S. F. Egerod, I. Weis, J. van Dijk, M. Kudchadkar, S. R. Ramelet, A. S. Ista, E. | Nurs Crit Care | 2022 |
delirium |
| Delirium in hospitalised adults with acute burns - A systematic review | Stanley, G. H. M. Barber, A. R. J. O'Brien, A. M. Hamill, C. Boardman, G. Frear, C. C. Edgar, D. W. Seymour, H. Wood, F. M. | Burns | 2022 |
Burns |
| Delirium associated with buprenorphine use in cardiac surgery: A retrospective cohort study | Selvaraj, T. Thangavel, P. Siddhaarth, K. | Indian J Anaesth | 2022 |
Aged |
| Influence of perioperative dexmedetomidine on the incidence of postoperative delirium in adult patients undergoing cardiac surgery | Patel, M. Onwochei, D. N. Desai, N. | Br J Anaesth | 2022 |
Adult |
| Association Between Implementation of a Geriatric Trauma Clinical Pathway and Changes in Rates of Delirium in Older Adults With Traumatic Injury | Park, C. Bharija, A. Mesias, M. Mitchell, A. Krishna, P. Storr-Street, N. Brown, A. Martin, M. Lu, A. C. Staudenmayer, K. L. | JAMA Surg | 2022 | |
| Intraoperative hyperoxygenation may negatively affect postoperative cognitive functions in coronary artery bypass graft operations: A randomized controlled study | Onur, T. Karaca, Ü Ata, F. Sayan, H. E. Onur, A. Yilmaz, C. Balkaya, A. N. Eriş, C. | J Card Surg | 2022 |
cardiopulmonary bypass |
| Investigation of Risk Factors for Postoperative Delirium after Transcatheter Aortic Valve Implantation: A Retrospective Study | Ogata, Y. Kobayashi, N. Yamauchi, M. | J Clin Med | 2022 |
aortic stenosis |
| Mobilization in the evening to prevent delirium: A pilot randomized trial | Nydahl, P. McWilliams, D. Weiler, N. Borzikowsky, C. Howroyd, F. Brobeil, A. Lindner, M. von Haken, R. | Nurs Crit Care | 2022 |
Critical Care |
| Delirium on stroke units: a prospective, multicentric quality-improvement project | Nydahl, P. Baumgarte, F. Berg, D. Bergjan, M. Borzikowsky, C. Franke, C. Green, D. Hannig, A. Hansen, H. C. Hauss, A. Hansen, U. Istel, R. Krämer, N. Krause, K. Lohrmann, R. Mohammadzadeh-Vazifeh, M. Osterbrink, J. Palm, F. Petersen, T. Schöller, B. Sto | J Neurol | 2022 |
*Delirium/diagnosis/epidemiology/etiology |
| The relationship of acute delirium with cognitive and psychiatric symptoms after stroke: a longitudinal study | Nerdal, V. Gjestad, E. Saltvedt, I. Munthe-Kaas, R. Ihle-Hansen, H. Ryum, T. Lydersen, S. Grambaite, R. | BMC Neurol | 2022 |
Aged |
| Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial | Neerland, B. E. Busund, R. Haaverstad, R. Helbostad, J. L. Landsverk, S. A. Martinaityte, I. Norum, H. M. Ræder, J. Selbaek, G. Simpson, M. R. Skaar, E. Skjærvold, N. K. Skovlund, E. Slooter, A. J. Svendsen Ø, S. Tønnessen, T. Wahba, A. Zetterberg, H. | BMJ Open | 2022 |
Adrenergic alpha-2 Receptor Agonists/therapeutic use |
| Does modulation of glymphatic system reduce delirium via waste clearance? | Naaz, S. Asghar, A. | J Anaesthesiol Clin Pharmacol | 2022 | |
| Delirium in elderly postoperative patients: A prospective cohort study | Muzzana, C. Mantovan, F. Huber, M. K. Trevisani, K. Niederbacher, S. Kugler, A. Ausserhofer, D. | Nurs Open | 2022 |
delirium |
| Antimicrobial neurotoxicity: an under-recognised cause of delirium | Moynan, D. Maqbool, E. de Barra, E. | Acute Med | 2022 |
Aged |
| CORR Insights®: Does the SORG Orthopaedic Research Group Hip Fracture Delirium Algorithm Perform Well on an Independent Intercontinental Cohort of Patients With Hip Fractures Who Are 60 Years or Older? | Michelson, J. D. | Clin Orthop Relat Res | 2022 | |
| Drug Choice for Hyperactive Delirium in Terminally-Ill Cancer Patients: A Nationwide Survey | Matsuda, Y. Morita, T. Oya, K. Tagami, K. Naito, A. S. Kashiwagi, H. Otani, H. | J Pain Symptom Manage | 2022 |
cancer |
| Implementing delirium screening in the emergency department: a quality improvement project | Martin, L. Lyons, M. Patton, A. O. Driscoll M McLoughlin, K. Hannon, E. Deasy, C. | BMJ Open Qual | 2022 |
Aged |
| Evaluation of the association of anticholinergic burden and delirium in older hospitalised patients - A cohort study comparing 19 anticholinergic burden scales | Lisibach, A. Gallucci, G. Benelli, V. Kälin, R. Schulthess, S. Beeler, P. E. Csajka, C. Lutters, M. | Br J Clin Pharmacol | 2022 |
Doss |
| Demand Ischemia as a Predictor of Mortality in Older Patients With Delirium | Kumar, M. Patil, S. Godoy, L. D. C. Kuo, C. L. Swede, H. Kuchel, G. A. Chen, K. | Front Cardiovasc Med | 2022 |
clinical outcomes |
| Structured Delirium Management in the Hospital | Krämer, J. Nolte, K. Zupanc, L. Schnitker, S. Roos, A. Göpel, C. Cid, J. S. Eichler, K. Hooven, T. V. D. Hempel, G. Pavenstädt, H. J. Klaas, C. Gosheger, G. Raschke, M. J. Wiendl, H. Duning, T. | Dtsch Arztebl Int | 2022 |
Activities of Daily Living |
| A machine learning approach to identifying delirium from electronic health records | Kim, J. H. Hua, M. Whittington, R. A. Lee, J. Liu, C. Ta, C. N. Marcantonio, E. R. Goldberg, T. E. Weng, C. | JAMIA Open | 2022 |
Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) |
| Effects of nonpharmacological interventions on sleep improvement and delirium prevention in critically ill patients: A systematic review and meta-analysis | Kang, J. Cho, Y. S. Lee, M. Yun, S. Jeong, Y. J. Won, Y. H. Hong, J. Kim, S. | Aust Crit Care | 2022 |
Critical care |
| A machine-learning model to predict postoperative delirium following knee arthroplasty using electronic health records | Jung, J. W. Hwang, S. Ko, S. Jo, C. Park, H. Y. Han, H. S. Lee, M. C. Park, J. E. Ro, D. H. | BMC Psychiatry | 2022 |
*Arthroplasty, Replacement, Knee/adverse effects |
| Tranexamic Acid and the Risk of Delirium after Off-Pump Surgery | Hulde, N. Zittermann, A. Deutsch, M. A. Gummert, J. F. von Dossow, V. Koster, A. | Thorac Cardiovasc Surg | 2022 | |
| Early Serum Metabolism Profile of Post-operative Delirium in Elderly Patients Following Cardiac Surgery With Cardiopulmonary Bypass | Huang, H. Han, J. Li, Y. Yang, Y. Shen, J. Fu, Q. Chen, Y. | Front Aging Neurosci | 2022 |
cardiopulmonary bypass |
| Delirium Item Bank: Utilization to Evaluate and Create Delirium Instruments | Helfand, B. K. I. Tommet, D. Detroyer, E. Milisen, K. Adamis, D. Metzger, E. D. Marcantonio, E. R. Boudreaux, E. D. Inouye, S. K. Jones, R. N. | Dement Geriatr Cogn Disord | 2022 |
Aged |
| Low Dose Antipsychotics for the Treatment of Delirium in Hospitalized Elderly Patients and Their Effects on QTc Interval | Heidari, S. Kargar, M. | J Pharm Pract | 2022 |
adverse drug events |
| Melatonin and Its Analogs for Prevention of Post-cardiac Surgery Delirium: A Systematic Review and Meta-Analysis | Han, Y. Tian, Y. Wu, J. Zhu, X. Wang, W. Zeng, Z. Qin, Z. | Front Cardiovasc Med | 2022 |
cardiac |
| The Role of Acetylcholinesterase Inhibitors in the Treatment of Prolonged Postelectroconvulsive Therapy Delirium | Gutowski, B. Bomasang-Layno, E. | Case Rep Psychiatry | 2022 | |
| Risk factors for delirium in elderly patients after lumbar spinal fusion | Gold, C. Ray, E. Christianson, D. Park, B. Kournoutas, I. A. Kahn, T. A. Perez, E. A. Berger, J. I. Sander, K. Igram, C. A. Pugely, A. Olinger, C. R. Carnahan, R. Chen, P. F. Mueller, R. Hitchon, P. Howard, M. A. Banks, M. Sanders, R. D. Woodroffe, R. W. | Clin Neurol Neurosurg | 2022 |
Geriatric spine surgery |
| Instruments to Identify Delirium in Patients Recovering From Anesthesia: A Scoping Review | Gnatta, J. R. Cavassana, T. M. Nascimento, A. S. D. Poveda, V. B. | J Perianesth Nurs | 2022 |
delirium |
| Identifying Patients With Delirium Based on Unstructured Clinical Notes: Observational Study | Ge, W. Alabsi, H. Jain, A. Ye, E. Sun, H. Fernandes, M. Magdamo, C. Tesh, R. A. Collens, S. I. Newhouse, A. Mvr Moura, L. Zafar, S. Hsu, J. Akeju, O. Robbins, G. K. Mukerji, S. S. Das, S. Westover, M. B. | JMIR Form Res | 2022 |
clinical notes |
| Predictors of post-stroke delirium incidence and duration: results of a prospective observational study using high frequency delirium screening | Fleischmann, R. Andrasch, T. Warwas, S. Kunz, R. Gross, S. Witt, C. Ruhnau, J. Vogelgesang, A. Ulm, L. Mengel, A. von Sarnowski, B. | Int J Stroke | 2022 |
Acute stroke therapy |
| Italian Version of the Cornell Assessment of Pediatric Delirium: Evaluation of the Scale Reliability and Ability to Detect Delirium Compared to Pediatric Intensive Care Unit Physicians Clinical Evaluation | Fazio, P. C. Daverio, M. Masola, M. D'Angelo, I. Frison, S. Zaggia, C. Simeone, S. Pucciarelli, G. Gregori, D. Comoretto, R. Amigoni, A. | Front Pediatr | 2022 |
Capd |
| Regional anesthesia techniques and postoperative delirium: systematic review and meta-analysis | Fanelli, A. Balzani, E. Memtsoudis, S. Abdallah, F. W. Mariano, E. R. | Minerva Anestesiol | 2023 |
Aged |
| Delirium with delayed diagnosis of hereditary coproporphyria | Eroglu, S. Birsenogul, I. | Clin Case Rep | 2022 |
atrial fibrillation |
| The Preventive Effect of Transcutaneous Electrical Acupoint Stimulation on Postoperative Delirium in Elderly Patients with Time Factors: A Randomized Trial | Ding, L. Ning, J. Guo, Y. Wang, Q. Kou, S. Ke, H. Zhou, R. Yu, B. | J Integr Complement Med | 2022 |
inflammation response |
| Prophylactic use of ramelteon for delirium in hospitalized patients: A systematic review and meta-analyses | Dang, V. Mansukhani, M. P. Wang, Z. Vesely, E. K. Kolla, B. P. | J Acad Consult Liaison Psychiatry | 2022 |
Delirium |
| Longest and largest cohort study of delirium to date reinforces association while causation remains elusive | Cunningham, E. | J Neurol Neurosurg Psychiatry | 2022 |
Cognition |
| Documentation and Diagnosis of Delirium in Parkinson's Disease | Cullinan, R. J. Richardson, S. J. Yarnall, A. J. Burn, D. J. Allan, L. M. Lawson, R. A. | Acta Psychiatr Scand | 2022 |
Confusion |
| Avoiding pitfalls in the treatment of delirium | Chuang, Y. C. Lin, C. Y. Wang, J. K. | Aust N Z J Psychiatry | 2022 |
*Delirium/drug therapy |
| Less pharmacotherapy is more in delirium | Chou, S. T. Pogach, M. Rock, L. K. | Intensive Care Med | 2022 |
*Antipsychotic Agents/therapeutic use |
| Accuracies of Training Labels and Machine Learning Models: Experiments on Delirium and Simulated Data | Cheng, Y. Shao, Y. Rudolph, J. Weir, C. R. Sahlmann, B. Zeng-Treitler, Q. | Stud Health Technol Inform | 2022 |
*Delirium |
| E4BP4 Coordinates Circadian Control of Cognition in Delirium | Chen, M. Zhang, L. Shao, M. Du, J. Xiao, Y. Zhang, F. Zhang, T. Li, Y. Zhou, Q. Liu, K. Wang, Z. Wu, B. | Adv Sci (Weinh) | 2022 |
E4bp4 |
| Association Between Anesthetics and Postoperative Delirium in Elderly Patients Undergoing Spine Surgery: Propofol Versus Sevoflurane | Chang, J. E. Min, S. W. Kim, H. Won, D. Lee, J. M. Kim, T. K. Kim, C. Hwang, J. Y. | Global Spine J | 2022 |
anesthesia |
| Validation of a delirium predictive model in patients admitted to surgical intensive care units: a multicentre prospective observational cohort study | Chaiwat, O. Chittawatanarat, K. Mueankwan, S. Morakul, S. Dilokpattanamongkol, P. Thanakiattiwibun, C. Siriussawakul, A. | BMJ Open | 2022 |
Adult |
| Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial | Buren, M. A. Theologis, A. Zuraek, A. Behrends, M. Clark, A. J. Leung, J. M. | BMJ Open | 2022 |
Aged |
| Factors influencing resilience to postoperative delirium in adults undergoing elective orthopaedic surgery | Bowman, E. M. L. Cardwell, C. McAuley, D. F. McGuinness, B. Passmore, A. P. Beverland, D. Zetterberg, H. Schott, J. M. Cunningham, E. L. | Br J Surg | 2022 | |
| Delirium prediction in the ICU: designing a screening tool for preventive interventions | Bhattacharyya, A. Sheikhalishahi, S. Torbic, H. Yeung, W. Wang, T. Birst, J. Duggal, A. Celi, L. A. Osmani, V. | JAMIA Open | 2022 |
artificial intelligence |
| Regional vs General Anesthesia and Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery | Zhu, Z. Cao, P. Lin, L. | Jama | 2022 |
Aged |
| Melatonin intervention to prevent delirium in hospitalized patients: A meta-analysis | You, W. Fan, X. Y. Lei, C. Nie, C. C. Chen, Y. Wang, X. L. | World J Clin Cases | 2022 |
Delirium |
| Preoperative Low Physical Activity is a Predictor of Postoperative Delirium in Patients with Gastrointestinal Cancer: A Retrospective Study | Yanagisawa, T. Tatematsu, N. Horiuchi, M. Migitaka, S. Yasuda, S. Itatsu, K. Kubota, T. Sugiura, H. | Asian Pac J Cancer Prev | 2022 |
Activities of Daily Living |
| What is It Like to be Delirious? | Wijdicks, E. F. M. Rabinstein, A. A. | Neurocrit Care | 2022 |
Definitions |
| Impact of Pain, Agitation, and Delirium Bundle on Delirium and Cognitive Function | Wang, X. P. Lv, D. Chen, Y. F. Chen, N. Li, X. D. Xu, C. F. Li, Y. Tian, L. | J Nurs Res | 2022 | |
| Regional vs General Anesthesia and Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery | Uzoigwe, C. E. Campbell-Jones, F. | Jama | 2022 |
Aged |
| Improving delirium screening in older adults at the Royal United Hospital, Bath | Trew, C. A. Cross, R. Howell, K. Dyer, C. | Br J Hosp Med (Lond) | 2022 |
Aged |
| Assessing prevalence and independent predictors of postoperative delirium in patients with head and neck cancer | Tian, T. Xue, F. S. Shao, L. J. Z. Hu, B. | Br J Oral Maxillofac Surg | 2022 |
*Delirium/epidemiology/etiology |
| Delirium due to hip fracture is associated with activated immune-inflammatory pathways and a reduction in negative immunoregulatory mechanisms | Thisayakorn, P. Thipakorn, Y. Tantavisut, S. Sirivichayakul, S. Maes, M. | BMC Psychiatry | 2022 |
Aged |
| Retrospective evaluation of a delirium order set utilizing nonpharmacologic and pharmacologic interventions for the treatment of delirium in medical intensive care unit patients | Taylor, A. D. Chen, A. Reddy, A. J. Lewandowski, A. Torbic, H. | Am J Health Syst Pharm | 2022 |
Adolescent |
| Prevention of dexmedetomidine on postoperative delirium and early postoperative cognitive dysfunction in elderly patients undergoing hepatic lobectomy | Tang, Y. Wang, Y. Kong, G. Zhao, Y. Wei, L. Liu, J. | Zhong Nan Da Xue Xue Bao Yi Xue Ban | 2022 |
Aged |
| Prevalence, clinical features, and risk factors of delusions in patients with delirium | Tachibana, M. Inada, T. Ichida, M. Ozaki, N. | Int J Geriatr Psychiatry | 2022 | |
| Effect of sedative premedication with oral midazolam on postanesthesia care unit delirium in older adults: a secondary analysis following an uncontrolled before-after design | Stuff, K. Kainz, E. Kahl, U. Pinnschmidt, H. Beck, S. von Breunig, F. Nitzschke, R. Funcke, S. Zöllner, C. Fischer, M. | Perioper Med (Lond) | 2022 |
Anesthesia |
| Associations of Smoking With Delirium and Opioid Use in Older Adults With Traumatic Hip Fracture | Salottolo, K. Meinig, R. Fine, L. Kelly, M. Madayag, R. Ekengren, F. Tanner, A., 2nd Bar-Or, D. | J Am Acad Orthop Surg Glob Res Rev | 2022 |
Aged |
| Impact of delirium on mortality in patients hospitalized for heart failure | Ritchie, C. Walters, R. W. Ramaswamy, S. Alla, V. M. | Int J Psychiatry Med | 2022 |
Aged |
| Risk for post-operative delirium related to comorbidities in older adult cardiac patients: An integrative review | Ramos, M. D. Vergara, F. H. Shackleford, J. Briggs, C. Gomez, C. Mofazali, M. Preston, J. | J Clin Nurs | 2022 |
cardiac surgery |
| Diagnosis and management of delirium in hospital oncology services | Ramírez Zuluaga, L. P. Ruano Restrepo, M. I. Osorio Bermúdez, J. D. Díaz Vallejo, J. A. | J Geriatr Oncol | 2022 |
*Delirium/diagnosis/etiology/therapy |
| Cognitive Predictors of Delirium on Long-Term Follow-Up after TIA and Stroke: Population-Based Cohort Study | Pendlebury, S. T. Thomson, R. J. Welch, S. J. V. Rothwell, P. M. | Cerebrovasc Dis | 2022 |
Aged |
| Plasma neurofilament light chain protein as a predictor of days in delirium and deep sedation, mortality and length of stay in critically ill patients | Page, V. J. Watne, L. O. Heslegrave, A. Clark, A. McAuley, D. F. Sanders, R. D. Zetterberg, H. | EBioMedicine | 2022 |
Biomarker |
| Feasibility of Machine Learning and Logistic Regression Algorithms to Predict Outcome in Orthopaedic Trauma Surgery | Oosterhoff, J. H. F. Gravesteijn, B. Y. Karhade, A. V. Jaarsma, R. L. Kerkhoffs, Gmmj Ring, D. Schwab, J. H. Steyerberg, E. W. Doornberg, J. N. | J Bone Joint Surg Am | 2022 |
Algorithms |
| Delirium detection methodologies: Implications for outcome measurement in clinical trials in postoperative delirium | Oh, E. S. Rosenberg, P. B. Wang, N. Y. Sieber, F. E. Neufeld, K. J. | Int J Geriatr Psychiatry | 2022 |
Aged |
| Nurse staffing levels are not associated with appearance, duration or solution of delirium in stroke patients | Nydahl, P. Meyne, J. Osterbrink, J. Margraf, N. G. | Intensive Crit Care Nurs | 2022 |
*Delirium/complications |
| Regional vs General Anesthesia and Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery | Nobuhara, C. Devinney, M., Jr. Berger, M. | Jama | 2022 |
Aged |
| Linking Perioperative Medications and Delirium | Nathan, N. | Anesth Analg | 2022 |
*Delirium/chemically induced/diagnosis |
| Prolonged and severe post-electroconvulsive therapy delirium with concurrent clozapine therapy | Melnikoff, E. Thomas Johnson, E. Walker, F. Itrat, Q. Jagadheesan, K. | Aust N Z J Psychiatry | 2022 |
*Antipsychotic Agents/adverse effects |
| 'Excited Delirium', acute behavioural disturbance, death and diagnosis | McGuinness, T. Lipsedge, M. | Psychol Med | 2022 |
Acute behavioural disturbance |
| Effects of non-pharmacologic prevention on delirium in critically ill patients: A network meta-analysis | Matsuura, Y. Ohno, Y. Toyoshima, M. Ueno, T. | Nurs Crit Care | 2022 |
acute encephalopathy |
| Melatonin Receptor Agonists for the Prevention of Delirium: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials | Maneeton, B. Kongsaengdao, S. Maneeton, N. Likhitsathian, S. Woottiluk, P. Kawilapat, S. Srisurapanont, M. | Curr Neuropharmacol | 2022 |
Delirium |
| Potential Value of Serum Lipid in the Identication of Postoperative Delirium Undergoing Knee/Hip Arthroplasty: The Perioperative Neurocognitive Disorder and Biomarker Lifestyle Study | Lin, Y. Peng, X. Lin, X. Deng, X. Liu, F. Tao, H. Dong, R. Wang, B. Bi, Y. | Front Psychiatry | 2022 |
cholesterol |
| Habitual tea consumption and postoperative delirium after total hip/knee arthroplasty in elderly patients: The PNDABLE study | Lin, X. Li, X. X. Dong, R. Wang, B. Bi, Y. L. | Brain Behav | 2022 |
cholinergic nerve system |
| Delirium and the risk of developing dementia: a cohort study of 12 949 patients | Leighton, S. P. Herron, J. W. Jackson, E. Sheridan, M. Deligianni, F. Cavanagh, J. | J Neurol Neurosurg Psychiatry | 2022 |
Dementia |
| Delirium risk factors analysis post proximal femur fracture surgery in elderly | Leigheb, M. De Sire, A. Zeppegno, P. Forni, F. Sgreccia, M. Gagliardi, V. P. Pogliacomi, F. Sabbatini, M. | Acta Biomed | 2022 |
Aged |
| A Scoping Review of the Incidence, Predictors, and Outcomes of Delirium Among Critically Ill Stroke Patients | Lawson, T. N. Balas, M. C. McNett, M. | J Neurosci Nurs | 2022 |
Adult |
| Non-Pharmacological Nursing Interventions to Prevent Delirium in ICU Patients-An Umbrella Review with Implications for Evidence-Based Practice | Lange, S. Mędrzycka-Dąbrowska, W. Friganovic, A. Oomen, B. Krupa, S. | J Pers Med | 2022 |
Icu |
| A decision tree prediction model for a short-term outcome of delirium in patients with advanced cancer receiving pharmacological interventions: A secondary analysis of a multicenter and prospective observational study (Phase-R) | Kurisu, K. Inada, S. Maeda, I. Ogawa, A. Iwase, S. Akechi, T. Morita, T. Oyamada, S. Yamaguchi, T. Imai, K. Nakahara, R. Kaneishi, K. Nakajima, N. Sumitani, M. Yoshiuchi, K. | Palliat Support Care | 2022 |
Decision Trees |