What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| The economic cost of delirium: A systematic review and quality assessment | Kinchin, I. Mitchell, E. Agar, M. Trépel, D. | Alzheimers Dement | 2021 |
Cost-Benefit Analysis/*economics |
| The Risk of Preoperative Central Nervous System-Acting Medications on Delirium Following Hip or Knee Surgery: A Matched Case-Control Study | Kassie, G. M. Roughead, E. E. Nguyen, T. A. Pratt, N. L. Kalisch Ellett, L. M. | Drug Saf | 2021 |
Preoperative Central Nervous System Delirium Hip or Knee Surgery Matched Case-Control Study |
| Association between ankle brachial index and development of postoperative intensive care unit delirium in patients with peripheral arterial disease | Kang, J. An, J. H. Jeon, H. J. Park, Y. J. | Sci Rep | 2021 |
Aged |
| Incidence and predictors of delirium on the intensive care unit in patients with acute kidney injury, insight from a retrospective registry | Jäckel, M. Aicher, N. Rilinger, J. Bemtgen, X. Widmeier, E. Wengenmayer, T. Duerschmied, D. Biever, P. M. Stachon, P. Bode, C. Staudacher, D. L. | Sci Rep | 2021 |
Acute Kidney Injury/*diagnosis/epidemiology |
| Advantages of score-based delirium detection compared to a clinical delirium assessment-a retrospective, monocentric cohort study | Jäckel, M. Aicher, N. Bemtgen, X. Rilinger, J. Zotzmann, V. Biever, P. M. Supady, A. Stachon, P. Duerschmied, D. Wengenmayer, T. Bode, C. Staudacher, D. L. | PLoS One | 2021 |
score-based delirium detection clinical delirium monocentric cohort study |
| A Comparison of Dexmedetomidine and Propofol on Emergence Delirium in Children Undergoing Cleft Palate Surgery With Sevoflurane-Based Anesthesia | Huang, L. Wang, L. Peng, W. Qin, C. | J Craniofac Surg | 2021 |
Emergence Delirium Children Cleft Palate Surgery Sevoflurane |
| Automated machine learning-based model predicts postoperative delirium using readily extractable perioperative collected electronic data | Hu, X. Y. Liu, H. Zhao, X. Sun, X. Zhou, J. Gao, X. Guan, H. L. Zhou, Y. Zhao, Q. Han, Y. Cao, J. L. | CNS Neurosci Ther | 2021 |
delirium |
| Feasibility of low-dose dexmedetomidine for prevention of postoperative delirium after intracranial operations: a pilot randomized controlled trial | He, X. Cheng, K. M. Duan, Y. Q. Xu, S. S. Gao, H. R. Miao, M. Y. Li, H. L. Chen, K. Yang, Y. L. Zhang, L. Gu, H. Q. Zhou, J. X. | BMC Neurol | 2021 |
Delirium |
| Reliability and validity of the Japanese version of the 4A's Test for delirium screening in the elderly patient | Hasegawa, T. Seo, T. Kubota, Y. Sudo, T. Yokota, K. Miyazaki, N. Muranaka, A. Hirano, S. Yamauchi, A. Nagashima, K. Iyo, M. Sakai, I. | Asian J Psychiatr | 2021 |
Attention |
| Neural autoantibodies in delirium | Hansen, N. Krasiuk, I. Titsch, T. | J Autoimmun | 2021 |
Cognitive dysfunction |
| Risk Factors for Delirium in the Palliative Care Population: A Systematic Review and Meta-Analysis | Guo, D. Lin, T. Deng, C. Zheng, Y. Gao, L. Yue, J. | Front Psychiatry | 2021 |
delirium |
| Incidence, risk factors, and consequences of emergence delirium after elective brain tumor resection | Gu, W. J. Zhou, J. X. Ji, R. Q. Zhou, L. Y. Wang, C. M. | Surgeon | 2021 |
Emergence delirium |
| A scientometric study of publications on delirium from 2001 to 2020 | Grover, S. Gupta, B. M | Asian J Psychiatr | 2021 |
Aged |
| The neuropsychological profile of delirium vulnerability: A systematic review and meta-analysis | Ghezzi, E. S. Ross, T. J. Sharman, R. Davis, D. Boord, M. S. Thanabalan, T. Thomas, J. Keage, H. A. D. | Neurosci Biobehav Rev | 2021 |
ageing |
| Cognitive Functionality of Patients with Delirium after Stroke | Dostović, Z. Ibrahimagić, OĆ Smajlović, D. Kunić, S. Čustović, A. | Psychiatr Danub | 2021 |
Cognition |
| Sleep quality and emergence delirium in children undergoing strabismus surgery: a comparison between preschool- and school-age patients | Do, W. Kim, H. S. Kim, S. H. Kang, H. Lee, D. Baik, J. Lee, H. J. Hong, J. M. | BMC Anesthesiol | 2021 |
*Emergence delirium |
| Multicomponent nursing program to prevent delirium in critically ill patients: a randomized clinical trial | Contreras, C. C. T. Esteban, A. N. P. Parra, M. D. Romero, M. K. R. Silva, C. G. D. Buitrago, N. P. D. | Rev Gaucha Enferm | 2021 |
*Critical Illness |
| Longitudinal validation of an electronic health record delirium prediction model applied at admission in COVID-19 patients | Castro, V. M. Hart, K. L. Sacks, C. A. Murphy, S. N. Perlis, R. H. McCoy, T. H., Jr. | Gen Hosp Psychiatry | 2021 |
Covid-19 |
| Independent, Differential Effects of Delirium on Disability and Mortality Risk After Hip Fracture | Cartei, A. Mossello, E. Ceccofiglio, A. Rubbieri, G. Polidori, G. Ranalli, C. Cammilli, A. Curcio, M. Cavallini, M. C. Mannarino, G. M. Ungar, A. Toccafondi, G. Peris, A. Marchionni, N. Rostagno, C. | J Am Med Dir Assoc | 2021 |
Delirium |
| Melatonin and melatonin-receptor agonists to prevent delirium in hospitalized older adults: An umbrella review | Blodgett, T. J. Blodgett, N. P. | Geriatr Nurs | 2021 |
Circadian Rhythm |
| Barriers to completing the 4AT for delirium and its clinical implementation in two hospitals: a mixed-methods study | Alhaidari, A. A. O. Matsis, K. P. | Eur Geriatr Med | 2021 |
Delirium |
| The relationship between sensory stimuli and the physical environment in complex healthcare settings: A systematic literature review | Bayramzadeh, S. Ahmadpour, S. Aghaei, P. | Intensive Crit Care Nurs | 2021 |
*Communication |
| Simultaneous bilateral total knee arthroplasty is safe and effective for patients in different ages | Ariga, A. Kohno, Y. Nakagawa, Y. Watanabe, T. Katagiri, H. Ohara, T. Shioda, M. Ozeki, N. Amemiya, M. Okawa, A. Sekiya, I. Koga, H. | J Orthop Sci | 2021 |
Age groups |
| Machine Learning Algorithm Using Electronic Chart-Derived Data to Predict Delirium After Elderly Hip Fracture Surgeries: A Retrospective Case-Control Study | Zhao, H. You, J. Peng, Y. Feng, Y. | Front Surg | 2021 |
delirium |
| The Effect of Data Length on the Assessment of Dynamic Cerebral Autoregulation with Transfer Function Analysis in Neurological ICU Patients | Zhang, W. Lu, H. Zhang, P. Mo, X. Ou, A. Liu, J. Zhong, J. | Neurocrit Care | 2021 |
Data length |
| Clinical Features and Outcomes of Neuropsychiatric Systemic Lupus Erythematosus in China | Zhang, S. Li, M. Zhang, L. Wang, Z. Wang, Q. You, H. Wang, Y. Li, M. Zeng, X. | J Immunol Res | 2021 |
Adult |
| Noncontact Monitoring of Heart Rate and Heart Rate Variability in Geriatric Patients Using Photoplethysmography Imaging | Yu, X. Laurentius, T. Bollheimer, C. Leonhardt, S. Antink, C. H. | IEEE J Biomed Health Inform | 2021 |
Aged |
| Non-Contact Measurement of Heart Rate Variability in Frail Geriatric Patients: Response to Early Geriatric Rehabilitation and Comparison with Healthy Old Community-Dwelling Individuals - A Pilot Study | Yu, X. Hoog Antink, C. Leonhardt, S. Bollheimer, L. C. Laurentius, T. | Gerontology | 2021 |
Frailty |
| Aggressive patient behaviours and unplanned nursing staff leave - is there an association? | Yu, J. J. Holbeach, E. | Int J Ment Health Nurs | 2021 |
Aggression |
| The Significant Prognostic Factors in Prolonged Intensive/High Care Unit Stay After Living Donor Liver Transplantation | Yoshiya, S. Harada, N. Tomiyama, T. Takeishi, K. Toshima, T. Iguchi, T. Itoh, S. Ninomiya, M. Yoshizumi, T. Mori, M. | Transplant Proc | 2021 |
Adult |
| Mode displaying mouse cursors for reducing input language mode confusion: Utility and user attitude evaluation | Yoo, T. Lee, H. Hyun, S. Park, W. | Appl Ergon | 2021 |
Confusion |
| Incidence and influencing factors of post-intensive care cognitive impairment | Yao, L. Li, Y. Yin, R. Yang, L. Ding, N. Li, B. Shen, X. Zhang, Z. | Intensive Crit Care Nurs | 2021 |
Apache |
| Validation of the Simplified Palliative Prognostic Index to Predict Survival for Advanced Cancer Patients in Home Hospice Setting | Yang, H. J. Yoon, S. J. Kim, J. S. Kim, S. S. Jung, J. G. Suh, W. Y. Lee, S. Kim, H. G. Lee, Y. W. | Korean J Fam Med | 2021 |
Hospice Care |
| Oral corticosteroid dosage and clinical presentation of psychiatric conditions after steroid use: A consultation-liaison psychiatry service's experience | Yagi, Y. Takahashi, Y. Ogata, Y. Yamana, H. Kumakura, Y. Ichihashi, K. Kasai, K. Kondo, S. | Neuropsychopharmacol Rep | 2021 |
consultation-liaison psychiatry |
| Machine learning-assisted screening for cognitive impairment in the emergency department | Yadgir, S. R. Engstrom, C. Jacobsohn, G. C. Green, R. K. Jones, C. M. C. Cushman, J. T. Caprio, T. V. Kind, A. J. H. Lohmeier, M. Shah, M. N. Patterson, B. W. | J Am Geriatr Soc | 2021 |
cognitive impairment |
| Effects of perioperative rosuvastatin on postoperative delirium in elderly patients: A randomized, double-blind, and placebo-controlled trial | Xu, X. Q. Luo, J. Z. Li, X. Y. Tang, H. Q. Lu, W. H. | World J Clin Cases | 2021 |
Elderly |
| Is Perioperative Dexmedetomidine Associated With a Reduced Risk of Perioperative Neurocognitive Disorders Following Cardiac Surgery? A Systematic Review and Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials | Xiong, X. Chen, D. Shi, J. | Front Med (Lausanne) | 2021 |
cardiac surgery |
| The effect of pre-operative methylprednisolone on postoperative delirium in elderly patients undergoing gastrointestinal surgery: a randomized, double-blind, placebo-controlled trial | Xiang, X. B. Chen, H. Wu, Y. L. Wang, K. Yue, X. Cheng, X. Q. | J Gerontol A Biol Sci Med Sci | 2021 |
Delirium |
| Social Determinants of Health and Delirium Occurrence and Duration in Critically Ill Adults | Wu, T. T. Zegers, M. Kooken, R. Griffith, J. L. Molnar, B. E. Devlin, J. W. van den Boogaard, M. | Crit Care Explor | 2021 |
delirium |
| Implementation of a Frailty Assessment and Targeted Care Interventions and Its Association with Reduced Postoperative Complications in Elderly Surgical Patients | Wilson, S. Sutherland, E. Razak, A. O'Brien, M. Ding, C. Nguyen, T. Rosenkranz, P. Sanchez, S. E. | J Am Coll Surg | 2021 |
Frailty, Postoperative outcomes, Geriatrics, Frailty assessment |
| Prevalence of Mimics and Severe Comorbidity in Patients with Clinically Suspected Transient Global Amnesia | Werner, R. Woehrle, J. C. | Cerebrovasc Dis | 2021 |
Adult |
| The risk of delirium and falls or fractures with the use of overactive bladder anticholinergic medications | Welk, B. Etaby, K. McArthur, E. Chou, Q. | Neurourol Urodyn | 2021 |
anticholinergics |
| Hospitalization Outcomes of Delirium in Patients Admitted to Acute Care Hospitals in Their Last Year of Life: A Population-Based Retrospective Cohort Study | Webber, C. Watt, C. L. Bush, S. H. Lawlor, P. G. Talarico, R. Tanuseputro, P. | J Pain Symptom Manage | 2021 |
Adult |
| Anticholinergics and clinical outcomes amongst people with pre-existing dementia: A systematic review | Wang, K. Alan, J. Page, A. T. Dimopoulos, E. Etherton-Beer, C. | Maturitas | 2021 |
Anticholinergic |
| Association Between Intraoperative Arterial Hypotension and Postoperative Delirium After Noncardiac Surgery: A Retrospective Multicenter Cohort Study | Wachtendorf, L. J. Azimaraghi, O. Santer, P. Linhardt, F. C. Blank, M. Suleiman, A. Ahn, C. Low, Y. H. Teja, B. Kendale, S. M. Schaefer, M. S. Houle, T. T. Pollard, R. J. Subramaniam, B. Eikermann, M. Wongtangman, K. | Anesth Analg | 2021 |
Intraoperative Arterial Hypotension, Postoperative delirium, Surgery, Anesthesia |
| Dynamic assessments of hepatic encephalopathy and ammonia levels predict mortality in acute-on-chronic liver failure | Verma, N. Dhiman, R. K. Choudhury, A. Taneja, S. Duseja, A. Singh, V. Al Mahtab, M. Devarbhavi, H. Shukla, A. Ning, Q. Hamid, S. S. Butt, A. S. Jafri, W. Tan, S. S. Hu, J. Zhongping, D. Treeprasertsuk, S. Lee, G. H. Ghazinyan, H. Lesmana, L. A. Sood, A. M | Hepatol Int | 2021 |
*Acute-On-Chronic Liver Failure |
| Evaluation of the impact of cataract surgery on cognitive function in very elderly patients: a prospective, observational study | Verdina, T. Stiro, F. Bruni, F. Spedicato, G. A. Mastropasqua, R. Cavallini, G. M. | Aging Clin Exp Res | 2021 |
6-item cognitive impairment test (6CIT) |
| Physiological Assessment of Delirium Severity: The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S) | van Sleuwen, M. Sun, H. Eckhardt, C. Neelagiri, A. Tesh, R. A. Westmeijer, M. Paixao, L. Rajan, S. Velpula Krishnamurthy, P. Sikka, P. Leone, M. J. Panneerselvam, E. Quadri, S. A. Akeju, O. Kimchi, E. Y. Westover, M. B. | Crit Care Med | 2021 |
van Sleuwen, M. |
| The effect of peri-operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non-cardiac surgical patients: a randomised, double-blind placebo-controlled trial | van Norden, J. Spies, C. D. Borchers, F. Mertens, M. Kurth, J. Heidgen, J. Pohrt, A. Mueller, A. | Anaesthesia | 2021 |
Aged |
| Rivastigmine for minor visual hallucinations in Parkinson's disease: A randomized controlled trial with 24 months follow-up | van Mierlo, T. J. M. Foncke, E. M. J. Post, B. Schmand, B. A. Bloem, B. R. van Harten, B. Tissingh, G. Munts, A. G. de Haan, R. J. de Bie, R. M. A. | Brain Behav | 2021 |
Cholinesterase Inhibitors |
| Effects of Orthogeriatric Care Models on Outcomes of Hip Fracture Patients: A Systematic Review and Meta-Analysis | Van Heghe, A. Mordant, G. Dupont, J. Dejaeger, M. Laurent, M. R. Gielen, E. | Calcif Tissue Int | 2021 |
Geriatric co-management |
| Automatic continuous EEG signal analysis for diagnosis of delirium in patients with sepsis | Urdanibia-Centelles, O. Nielsen, R. M. Rostrup, E. Vedel-Larsen, E. Thomsen, K. Nikolic, M. Johnsen, B. Møller, K. Lauritzen, M. Benedek, K. | Clin Neurophysiol | 2021 |
Automatic EEG |
| Evaluation of the effectiveness of delirium prevention care protocol for the patients with hip fracture: A randomised controlled study | Unal, N. Guvenc, G. Ilkin Naharci, M. | J Clin Nurs | 2021 |
nursing care |
| Association of poor sleep burden in middle age and older adults with risk for delirium during hospitalization | Ulsa, M. C. Zheng, X. Li, P. Gaba, A. Wong, P. M. Saxena, R. Scheer, F. Rutter, M. Akeju, O. Hu, K. Gao, L. | J Gerontol A Biol Sci Med Sci | 2021 |
Sleep health |
| Where should patients with or at risk of delirium be treated in an acute care system? Comparing the rates of delirium in patients receiving usual care vs alternative care: A systematic review and meta-analysis | Ukwuoma Ekeozor, C. Jeyaruban, D. Lasserson, D. | Int J Clin Pract | 2021 |
Critical Care |
| Restraint use in the acute-care hospital setting: A cross-sectional multi-centre study | Thomann, S. Zwakhalen, S. Richter, D. Bauer, S. Hahn, S. | Int J Nurs Stud | 2021 |
Cross-Sectional Studies |
| Immune, Blood Cell, and Blood Gas Biomarkers of Delirium in Elderly Individuals with Hip Fracture Surgery | Thisayakorn, P. Tangwongchai, S. Tantavisut, S. Thipakorn, Y. Sukhanonsawat, S. Wongwarawipat, T. Sirivichayakul, S. Maes, M. | Dement Geriatr Cogn Disord | 2021 |
Delirium |
| Delirium Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System (FAERS) | Teng, C. Frei, C. R. | Drugs Real World Outcomes | 2021 |
Delirium, Antibiotics, FDA Adverse Event Reporting System |
| The Impact of Aging on Symptom Prevalence and Management in Terminally ill Patients With Cancer | Tatokoro, M. Matsuo, N. | J Pain Symptom Manage | 2021 |
Age |
| Subjective strain of care experienced by pulmonary and critical care medical nurses when caring for patients with delirium: a cross-sectional study | Tan, H. Zhou, L. Wu, S. Dong, Q. Yang, L. Xu, J. Zhao, S. Wang, X. Yang, H. | BMC Health Serv Res | 2021 |
Critical Care |
| Circulating MicroRNAs and Novel Proteins as Potential Biomarkers of Neurological Complications after Heart Bypass Surgery | Szwed, K. Szwed, M. Kozakiewicz, M. Karłowska-Pik, J. Soja-Kukieła, N. Bartoszewska, A. Borkowska, A. | J Clin Med | 2021 |
Cabg |
| Evaluation of the implementation of multidisciplinary fast-track program for acute geriatric hip fractures at a University Hospital in resource-limited settings | Sura-Amonrattana, U. Tharmviboonsri, T. Unnanuntana, A. Tantigate, D. Srinonprasert, V. | BMC Geriatr | 2021 |
Aged |
| Perceptions of current occupational therapy practice with older adults experiencing delirium | Strecker, C. Hitch, D. | Australas J Ageing | 2021 |
Aged |
| Changes in autonomic tone during delirium in acute stroke patients assessed by pupillometry and skin conductance | Stokholm, J. Birkmose, L. K. H. Ahmed, Aabo Csillag, C. Kjær, T. W. Christensen, T. | J Neurol Sci | 2021 |
Autonomic Nervous System |
| Expression of HO1 and PER2 can predict the incidence of delirium in trauma patients with concomitant brain injury | Steimer, M. Kaiser, S. Ulbrich, F. Kalbhenn, J. Bürkle, H. Schallner, N. | Sci Rep | 2021 |
Biomarkers, Circadian rhythms and sleep, Translational research, Neurological manifestations |
| An implementation science approach to geriatric screening in an emergency department | Southerland, L. T. Hunold, K. M. Van Fossen, J. Caterino, J. M. Gulker, P. Stephens, J. A. Bischof, J. J. Farrell, E. Carpenter, C. R. Mion, L. C. | J Am Geriatr Soc | 2021 |
Cfir |
| Effectiveness of the ABCDEF bundle on delirium, functional outcomes and quality of life in intensive care patients: a study protocol for a randomised controlled trial with embedded process evaluation | Sosnowski, K. Mitchell, M. Cooke, M. White, H. Morrison, L. Lin, F. | BMJ Open | 2021 |
Critical Care |
| Effects of general versus subarachnoid anaesthesia on circadian melatonin rhythm and postoperative delirium in elderly patients undergoing hip fracture surgery: A prospective cohort clinical trial | Song, Y. Liu, Y. Yuan, Y. Jia, X. Zhang, W. Wang, G. Jia, Y. Wang, X. Liu, L. Li, W. Li, X. Cai, N. Liu, C. Li, Y. Han, Y. Zhou, Y. Mi, X. Shi, C. Wang, J. Q. Vuylsteke, A. Guo, X. Li, Z. | EBioMedicine | 2021 |
Circadian rhythm |
| Comparison of the Effects of Haloperidol and Dexmedetomidine on Delirium and Agitation in Patients with a Traumatic Brain Injury Admitted to the Intensive Care Unit | Soltani, F. Tabatabaei, S. Jannatmakan, F. Nasajian, N. Amiri, F. Darkhor, R. Moravej, M. | Anesth Pain Med | 2021 |
Delirium |
| Comparison of postoperative delirium within 24 hours between ketamine and propofol infusion during cardiopulmonary bypass machine: A randomized controlled trial | Siripoonyothai, S. Sindhvananda, W. | Ann Card Anaesth | 2021 |
*Cardiac surgery |
| Improving delirium detection in intensive care units: Multicomponent education and training program | Sinvani, L. Delle Site, C. Laumenede, T. Patel, V. Ardito, S. Ilyas, A. Hertz, C. Wolf-Klein, G. Pekmezaris, R. Hajizadeh, N. Thomas, L. | J Am Geriatr Soc | 2021 |
critical care nursing |
| Outcome, demography and resource utilization in ICU Patients with delirium and malignancy | Sieber, M. Rudiger, A. Schüpbach, R. Krüger, B. Schubert, M. Bettex, D. | Sci Rep | 2021 |
Medical research, Oncology, Delirium, ICU delirium, ICDSC, Malignancies |
| Prevalence of postoperative delirium with different combinations of intraoperative general anesthetic agents in patients undergoing cardiac surgery: A retrospective propensity-score-matched study | Shin, H. J. Choi, S. L. Na, H. S. | Medicine (Baltimore) | 2021 |
Aged |
| Is Comprehensive Geriatric Assessment Admission Avoidance Hospital at Home an Alternative to Hospital Admission for Older Persons? : A Randomized Trial | Shepperd, S. Butler, C. Cradduck-Bamford, A. Ellis, G. Gray, A. Hemsley, A. Khanna, P. Langhorne, P. Mort, S. Ramsay, S. Schiff, R. Stott, D. J. Wilkinson, A. Yu, L. M. Young, J. | Ann Intern Med | 2021 |
Aged |
| Delirium and abnormal autonomic nervous system response to head-up tilt testing | Shanahan, E. Ryan, S. Leahy, A. Sheehy, T. Costelloe, A. Roy, A. Galvin, R. Peters, C. Lyons, D. O'Connor, M. | Exp Gerontol | 2021 |
Aged, 80 and over |
| Understanding frailty among older people living in old age homes and the community in Nepal: A cross-sectional study | Shah, R. Carandang, R. R. Shibanuma, A. Ong, K. I. C. Kiriya, J. Jimba, M. | PLoS One | 2021 |
Activities of Daily Living |
| Death in delirious palliative-care patients occurs irrespective of age: A prospective, observational cohort study of 229 delirious palliative-care patients | Seiler, A. Blum, D. Hertler, C. Schettle, M. Zipser, C. M. Bode, L. Gehrke, S. Ernst, J. Schubert, M. von Känel, R. Boettger, S. | Palliat Support Care | 2021 |
Aged |
| Delirium Variability is Influenced by the Sound Environment (DEVISE Study): How Changes in the Intensive Care Unit soundscape affect delirium incidence | Sangari, A. Emhardt, E. A. Salas, B. Avery, A. Freundlich, R. E. Fabbri, D. Shotwell, M. S. Schlesinger, J. J. | J Med Syst | 2021 |
Critical Care |
| Delirium in Intensive Care Units: Perceptions of Physicians and Nurses | Salameh, B. Al Razeeni, D. M. Mansor, K. Abdallah, J. M. Ayed, A. Salem, H. | Crit Care Nurs Q | 2021 |
Critical Care |
| How to deal with the consent of adults with cognitive impairment involved in European geriatric living labs? | Sacco, G. Noublanche, F. Blazek, F. Hue, C. Carballido, L. Asfar, M. Allain, P. Annweiler, C. | Philos Ethics Humanit Med | 2021 |
Aged |
| Management of preoperative pain in elderly patients with moderate to severe cognitive deficits and hip fracture: a retrospective, monocentric study in an orthogeriatric unit | Ruel, M. Boussat, B. Boudissa, M. Garnier, V. Bioteau, C. Tonetti, J. Pailhe, R. Gavazzi, G. Drevet, S. | BMC Geriatr | 2021 |
Aged |
| Early high-dose vitamin C in post-cardiac arrest syndrome (VITaCCA): study protocol for a randomized, double-blind, multi-center, placebo-controlled trial | Rozemeijer, S. de Grooth, H. J. Elbers, P. W. G. Girbes, A. R. J. den Uil, C. A. Dubois, E. A. Wils, E. J. Rettig, T. C. D. van Zanten, A. R. H. Vink, R. van den Bogaard, B. Bosman, R. J. Oudemans-van Straaten, H. M. de Man, A. M. E. | Trials | 2021 |
Ascorbic Acid |
| Synergistic Impact of Systolic Blood Pressure and Perfusion Status on Mortality in Acute Heart Failure | Rossello, X. Bueno, H. Gil, V. Jacob, J. Martín-Sánchez, F. J. Llorens, P. Herrero Puente, P. Alquézar-Arbé, A. Espinosa, B. Raposeiras-Roubín, S. Müller, C. E. Mebazaa, A. Maggioni, A. P. Pocock, S. Chioncel, O. Miró, Ò | Circ Heart Fail | 2021 |
Acute Disease |
| The Impact of Nursing Delirium Preventive Interventions in the ICU: A Multicenter Cluster-randomized Controlled Clinical Trial | Rood, P. J. T. Zegers, M. Ramnarain, D. Koopmans, M. Klarenbeek, T. Ewalds, E. van der Steen, M. S. Oldenbeuving, A. W. Kuiper, M. A. Teerenstra, S. Adang, E. van Loon, L. M. Wassenaar, A. Vermeulen, H. Pickkers, P. van den Boogaard, M. | Am J Respir Crit Care Med | 2021 |
Aged |
| Heart rate variability and delirium in acute non-cardioembolic stroke: a prospective, cross-sectional, cohort study | Rollo, E. Marotta, J. Callea, A. Brunetti, V. Vollono, C. Scala, I. Imperatori, C. Frisullo, G. Broccolini, A. Della Marca, G. | Neurol Sci | 2021 |
Autonomic |
| The training needs of Korean intensive care unit nurses regarding delirium | Roh, Y. S. | Intensive Crit Care Nurs | 2021 |
Clinical Competence |
| Hospitalisation without delirium is not associated with cognitive decline in a population-based sample of older people-results from a nested, longitudinal cohort study | Richardson, S. J. Lawson, R. Davis, D. H. J. Stephan, B. C. M. Robinson, L. Matthews, F. E. Brayne, C. Barnes, L. E. Taylor, J. P. Parker, S. G. Allan, L. M. | Age Ageing | 2021 |
Aged |
| Recurrent delirium over 12 months predicts dementia: results of the Delirium and Cognitive Impact in Dementia (DECIDE) study | Richardson, S. J. Davis, D. H. J. Stephan, B. C. M. Robinson, L. Brayne, C. Barnes, L. E. Taylor, J. P. Parker, S. G. Allan, L. M. | Age Ageing | 2021 |
Cognition |
| Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated With Postoperative Delirium | Rhee, J. Kuznetsov, A. McKay, T. Lyons, M. Houstis, N. Mekkonen, J. Ethridge, B. Ibala, R. Hahm, E. Gitlin, J. Guseh, J. S. Kitchen, R. Rosenzweig, A. Shaefi, S. Flaczyk, A. Qu, J. Akeju, O. | Front Aging Neurosci | 2021 |
*il-6 |
| Comparison of Esophagectomy outcomes between a National Center, a National Audit Collaborative, and an International database using the Esophageal Complications Consensus Group (ECCG) standardized definitions | Reynolds, J. V. Donlon, N. Elliott, J. A. Donohoe, C. Ravi, N. Kuppusamy, M. K. Low, D. E. | Dis Esophagus | 2021 |
Aged |
| Health Profiles, Health Services Use, and Transition to Dementia in Inpatients With Late-Life Depression and Other Mental Illnesses | Reppermund, S. Heintze, T. Srasuebkul, P. Trollor, J. N. | J Am Med Dir Assoc | 2021 |
Aged |
| A Survey of Nurses' Perspectives on Delirium Screening in Older Adult Medical Inpatients With Limited English Proficiency | Reppas-Rindlisbacher, C. Panov, E. D. Cuperfain, A. B. Rawal, S. | J Gerontol Nurs | 2021 |
Aged |
| Post-hospital falls incidence and risk factors among older adults: a systematic review and meta-analysis | Qian, X. X. Chen, Z. Fong, D. Y. T. Ho, M. Chau, P. H. | Age Ageing | 2021 |
incidence |
| The prevalence of serotonin syndrome in an intensive care unit: A prospective observational study | Prakash, S. Rathore, C. Rana, K. | J Crit Care | 2021 |
Adult |
| Associations of subclinical heart failure and atrial fibrillation with mild cognitive impairment: a cross-sectional study in a subclinical heart failure screening programme | Potter, E. L. Ramkumar, S. Wright, L. Marwick, T. H. | BMJ Open | 2021 |
Aged |
| A One-Day Prospective National Observational Study on Sedation-Analgesia of Patients with Brain Injury in French Intensive Care Units: The SEDA-BIP-ICU (Sedation-Analgesia in Brain Injury Patient in ICU) Study | Poignant, S. Vigué, B. Balram, P. Biais, M. Carillon, R. Cottenceau, V. Dahyot-Fizelier, C. Degos, V. Geeraerts, T. Jeanjean, P. Vega, E. Lasocki, S. Espitalier, F. Laffon, M. | Neurocrit Care | 2021 |
Brain injury |
| Risk factors and adverse clinical outcomes of postoperative delirium in Thai elderly patients: A prospective cohort study | Pipanmekaporn, T. Punjasawadwong, Y. Wongpakaran, N. Wongpakaran, T. Suwannachai, K. Chittawatanarat, K. Mueankwan, S. | Perspect Psychiatr Care | 2021 |
Aged |
| Multifaceted intervention including Facebook-groups to improve guideline-adherence in ICU: A quasi-experimental interrupted time series study | Petosic, A. Småstuen, M. C. Beeckman, D. Flaatten, H. Sunde, K. Wøien, H. | Acta Anaesthesiol Scand | 2021 |
agitation/sedation |
| Perioperative Optimization of Senior Health in Spine Surgery: Impact on Postoperative Delirium | Pernik, M. N. Deme, P. R. Nguyen, M. L. Aoun, S. G. Adogwa, O. Hall, K. Stewart, N. A. Dosselman, L. J. El Tecle, N. E. McDonald, S. R. Bagley, C. A. Wingfield, S. A. | J Am Geriatr Soc | 2021 |
Aged |
| Postoperative delirium mediates 180-day mortality in orthopaedic trauma patients | Pedemonte, J. C. Sun, H. Franco-Garcia, E. Zhou, C. Heng, M. Quraishi, S. A. Westover, B. Akeju, O. | Br J Anaesth | 2021 |
Aged |