NIDUS Delirium Bibliography

Delirium Bibliography books graphic What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title: Intravenous infusion of dexmedetomidine during the surgery to prevent postoperative delirium and postoperative cognitive dysfunction undergoing non-cardiac surgery: a meta-analysis of randomized controlled trials

Authors: Wang, D. Liu, Z. Zhang, W. Zu, G. Tao, H. Bi, C.

Year: 2024

Journal: Eur J Med Res

Abstract: BACKGROUND: Dexmedetomidine plays a pivotal role in mitigating postoperative delirium and cognitive dysfunction while enhancing the overall quality of life among surgical patients. Nevertheless, the influence of dexmedetomidine on such complications in various anaesthesia techniques remains inadequately explored. As such, in the present study, a meta-analysis was conducted to comprehensively evaluate its effects on postoperative delirium and cognitive dysfunction. METHODS: A number of databases were searched for randomised controlled trials comparing intravenous dexmedetomidine to other interventions in preventing postoperative delirium and cognitive dysfunction in non-cardiac and non-neurosurgical patients. These databases included PubMed, Embase, and Cochrane Library. Statistical analysis and graphing were performed using Review Manager, STATA, the second version of the Cochrane risk-of-bias tool for randomised controlled trials, and GRADE profiler. MAIN RESULTS: This meta-analysis comprised a total of 24 randomised controlled trials, including 20 trials assessing postoperative delirium and 6 trials assessing postoperative cognitive dysfunction. Across these 24 studies, a statistically significant positive association was observed between intravenous administration of dexmedetomidine and a reduced incidence of postoperative delirium (RR: 0.55; 95% CI 0.47 to 0.64, p < 0.00001, I(2) = 2%) and postoperative cognitive dysfunction (RR: 0.60; 95% CI 0.38 to 0.96, p = 0.03, I(2) = 60%). Subgroup analysis did not reveal a significant difference in the incidence of postoperative delirium between the general anaesthesia and non-general anaesthesia groups, but a significant difference was observed in the incidence of postoperative cognitive dysfunction. Nonetheless, when the data were pooled, it was evident that the utilisation of dexmedetomidine was associated with an increased incidence of hypotension (RR: 1.42; 95% CI 1.08 to 1.86, p = 0.01, I(2) = 0%) and bradycardia (RR: 1.66; 95% CI 1.23 to 2.26, p = 0.001, I(2) = 0%) compared with other interventions. However, there was no significantly higher occurrence of hypertension in the DEX groups (RR = 1.35, 95% CI 0.81-2.24, p = 0.25, I(2) = 0%). CONCLUSION: Compared with other interventions, intravenous dexmedetomidine infusion during non-cardiac and non-neurosurgical procedures may significantly reduce the risk of postoperative delirium and cognitive dysfunction. The results of subgroup analysis reveal a consistent preventive effect on postoperative delirium in both general and non-general anaesthesia groups. Meanwhile, continuous infusion during general anaesthesia was more effective in reducing the risk of cognitive dysfunction. Despite such findings, hypotension and bradycardia were more frequent in patients who received dexmedetomidine during surgery.

PMID: PMID: 38637853

PMCID: PMC11025279

Keywords: Humans
Bradycardia/epidemiology
*Dexmedetomidine/therapeutic use
*Emergence Delirium/epidemiology/prevention & control
*Hypotension/epidemiology
Infusions, Intravenous
*Postoperative Cognitive Complications/prevention & control
Postoperative Complications/prevention & control/epidemiology
Quality of Life
Randomized Controlled Trials as Topic
Dexmedetomidine
Non-cardiac surgery and non-neurosurgery
Postoperative cognitive dysfunction
Postoperative delirium

Page(s)

Volume

Issue

Total Records Found: 6289, showing 100 per page
Title	Authors	Journal	Year	Keywords
Three-Minute Diagnostic Assessment for Delirium using the Confusion Assessment Method (3D-CAM): French translation and cultural adaptation	Gaudet, J. G. Kull, C. Eskenazi, M. L. Diaper, J. Maillard, J. Mollard, F. Marti, C. Marcantonio, E. R. Courvoisier, D. S. Walder, B.	Can J Anaesth	2022	3d-cam French adaptation delirium diagnosis surveys and questionnaire translation
Critical role of acute hypoxemia on the cognitive impairment after severe COVID-19 pneumonia: a multivariate causality model analysis	García-Grimshaw, M. Chirino-Pérez, A. Flores-Silva, F. D. Valdés-Ferrer, S. I. Vargas-Martínez, MlÁ Jiménez-Ávila, A. I. Chávez-Martínez, O. A. Ramos-Galicia, E. M. Marché-Fernández, O. A. Ramírez-Carrillo, M. F. Grajeda-González, S. L. Ramí	Neurol Sci	2022	Adolescent COVID-19/complications Cognitive Dysfunction/etiology Female Humans Hypoxia/etiology Male Middle Aged Prospective Studies Respiration, Artificial SARS-CoV-2 Covid-19 Cognition Cognitive impairment Hospitalization Inflammation Outcome
Prevalence, risk factors, and outcomes of subsyndromal delirium in older adults in hospital or long-term care settings: A systematic review and meta-analysis	Gao, Y. Gao, R. Yang, R. Gan, X.	Geriatr Nurs	2022	Older adults Outcomes Prevalence Risk factors Subsyndromal delirium Systematic review
Hospital-treated deliberate self-poisoning patients: Drug-induced delirium and clinical outcomes	Gale, L. McGill, K. Twaddell, S. Whyte, I. M. Lewin, T. J. Carter, G. L.	Aust N Z J Psychiatry	2022	Aged Antipsychotic Agents/adverse effects Benzodiazepines/therapeutic use Delirium/chemically induced/epidemiology Hospitals Humans Length of Stay Retrospective Studies Drug-induced delirium discharge destination *self-poisoning
An Inpatient Geriatrics Program with a Focus on Any Type of Cognitive Impairment Reduces Mortality	Flaherty, J. H. Bloomstone, J. A. Vicents Sande, E. Brantley, A. Semien, G. A.	J Nutr Health Aging	2022	Aged Cognitive Dysfunction Geriatric Assessment Geriatrics Humans Inpatients Retrospective Studies Cognitive impairment inpatient geriatrics program *mortality
Risk factors for delirium in adult patients receiving specialist palliative care: A systematic review and meta-analysis	Featherstone, I. Sheldon, T. Johnson, M. Woodhouse, R. Boland, J. W. Hosie, A. Lawlor, P. Russell, G. Bush, S. Siddiqi, N.	Palliat Med	2022	Adult Delirium Hospice and Palliative Care Nursing Humans Male Palliative Care Prospective Studies Risk Factors Risk factors meta-analysis palliative care systematic review
Incidence of postoperative delirium in patients with preoperative and postoperative Obstructive Sleep Apnea Syndrome. A Systematic Review of the literature	Dooijeweerd, S. Torensma, B. Faraj, D. Eldawlatly, A. A.	Saudi J Anaesth	2022	Delirium Osas postoperative
The relationship between body mass index and postoperative delirium	Deng, X. Qin, P. Lin, Y. Tao, H. Liu, F. Lin, X. Wang, B. Bi, Y.	Brain Behav	2022	body mass index cerebrospinal fluid mediation analysis postoperative delirium tau proteins
Pretransplant physical frailty, postoperative delirium, and short-term outcomes among older lung transplant recipients	Dalton, T. Snyder, L. Buckley, E. B. Smith, P.	Exp Gerontol	2022	Delirium Frailty Lung transplant
Effects of dexmedetomidine on surgery for type A acute aortic dissection outcome	Cheng, Y. T. Lee, K. T. Chang, C. H. Wu, V. C. Chan, Y. S. Chen, D. Y. Chu, P. H. Chou, A. H. Liu, K. S. Chen, S. W.	Sci Rep	2022	Acute Kidney Injury/etiology/mortality/therapy Aged Aneurysm, Dissecting/mortality/therapy Atrial Fibrillation/etiology/mortality/therapy Cardiac Surgical Procedures Delirium/etiology/mortality/therapy Dexmedetomidine/administration & dosage Hospital Mortality Humans Male Middle Aged *Postoperative Complications/mortality/therapy Retrospective Studies Taiwan/epidemiology
Global research trends in perioperative care for the elderly: a bibliometric and visualized study	Chen, Q. Wang, Y. Song, S. Xie, G. Cheng, B. Fang, X.	J Anesth	2022	Aged Bibliometrics Delirium Humans Perioperative Care United States Bibliometric analysis Elderly Global trends Visualized analysis
Assessment of potential selection bias in neuroimaging studies of postoperative delirium and cognitive decline: lessons from the SAGES study	Cavallari, M. Fong, T. G. Touroutoglou, A. Dickerson, B. C. Schmitt, E. Travison, T. G. Marcantonio, E. R. Ngo, L. H. Libermann, T. Pascual-Leone, A. Shafi, M. M. Inouye, S. K. Jones, R. N.	Brain Imaging Behav	2022	Aging Alzheimer’s disease Delirium Selection bias Surgery
Health outcomes after the implementation of multidisciplinary clinical guidelines for the care of hip fractures	Casanova Querol, T. Santiago Bautista, J. M. Lafuente Salinas, M. Güell Farré, E. Girós Torres, J. Martín-Baranera, M. Miralles Basseda, R.	Rev Clin Esp (Barc)	2022	Aged Aged, 80 and over Female *Hip Fractures/therapy Humans Length of Stay Outcome Assessment, Health Care Patient Discharge Prospective Studies Atención continuada Continued care Fractura de cadera Hip fracture Internal Medicine Medicina Interna Orthogeriatrics Ortogeriatría
Health outcomes after the implementation of multidisciplinary clinical guidelines for the care of hip fractures	Casanova Querol, T. Santiago Bautista, J. M. Lafuente Salinas, M. Güell Farré, E. Girós Torres, J. Martín-Baranera, M. Miralles Basseda, R.	Rev Clin Esp (Barc)	2022	Aged Aged, 80 and over Female *Hip Fractures/therapy Humans Length of Stay Outcome Assessment, Health Care Patient Discharge Prospective Studies Atención continuada Continued care Fractura de cadera Hip fracture Internal Medicine Medicina Interna Orthogeriatrics Ortogeriatría
Health outcomes after the implementation of multidisciplinary clinical guidelines for the care of hip fractures	Casanova Querol, T. Santiago Bautista, J. M. Lafuente Salinas, M. Güell Farré, E. Girós Torres, J. Martín-Baranera, M. Miralles Basseda, R.	Rev Clin Esp (Barc)	2022	Aged Aged, 80 and over Female *Hip Fractures/therapy Humans Length of Stay Outcome Assessment, Health Care Patient Discharge Prospective Studies Atención continuada Continued care Fractura de cadera Hip fracture Internal Medicine Medicina Interna Orthogeriatrics Ortogeriatría
Melatonin in ICU delirium: shining light on the hormone of darkness	Burry, L. Sonneville, R. Ely, E. W.	Intensive Care Med	2022
The association between the inflammatory response following surgery and post-operative delirium in older oncological patients: a prospective cohort study	Brattinga, B. Plas, M. Spikman, J. M. Rutgers, A. de Haan, J. J. Absalom, A. R. van der Wal-Huisman, H. de Bock, G. H. van Leeuwen, B. L.	Age Ageing	2022	Aged Aged, 80 and over C-Reactive Protein/analysis Cohort Studies Delirium/diagnosis/etiology Humans Postoperative Complications/diagnosis/etiology Prospective Studies Post-operative delirium cancer inflammatory response neuroinflammation older patients older people
Brain Network Dysfunction in Poststroke Delirium and Spatial Neglect: An fMRI Study	Boukrina, O. Kowalczyk, M. Koush, Y. Kong, Y. Barrett, A. M.	Stroke	2022	Adult Aged Aged, 80 and over Brain/diagnostic imaging Brain Mapping Delirium/diagnostic imaging/etiology Female Functional Laterality/physiology Humans Magnetic Resonance Imaging Male Middle Aged Nerve Net/diagnostic imaging Perceptual Disorders/diagnostic imaging/etiology Stroke/complications/diagnostic imaging MRI, functional attention basal ganglia delirium incidence ischemic stroke prevalence
Postoperative delirium prediction using machine learning models and preoperative electronic health record data	Bishara, A. Chiu, C. Whitlock, E. L. Douglas, V. C. Lee, S. Butte, A. J. Leung, J. M. Donovan, A. L.	BMC Anesthesiol	2022	Aged Cohort Studies Delirium/diagnosis Electronic Health Records/statistics & numerical data Female Humans Machine Learning Male Middle Aged Postoperative Complications/diagnosis Predictive Value of Tests Preoperative Period Reproducibility of Results Retrospective Studies Delirium prevention Geriatric surgery Postoperative delirium Risk prediction model improve healthcare quality interventions. 2.AJB is a co-founder and consultant to Personalis and NuMedii consultant to Samsung, Mango Tree Corporation, and in the recent past, 10x Genomics, Helix, Pathway Genomics, and Verinata (Illumina) has served on paid advisory panels or boards for Geisinger Health, Regenstrief Institute, Gerson Lehman Group, AlphaSights, Covance, Novartis, Genentech, and Merck, and Roche is a shareholder in Personalis and NuMedii is a minor shareholder in Apple, Facebook, Alphabet (Google), Microsoft, Amazon, Snap, 10x Genomics, Illumina, CVS, Nuna Health, Assay Depot, Vet24seven, Regeneron, Sanofi, Royalty Pharma, AstraZeneca, Moderna, Biogen, and Sutro, and several other non-health related companies and mutual funds and has received honoraria and travel reimbursement for invited talks from Johnson and Johnson, Roche, Genentech, Pfizer, Merck, Lilly, Takeda, Varian, Mars, Siemens, Optum, Abbott, Celgene, AstraZeneca, AbbVie, Westat, and many academic institutions, medical or disease specific foundations and associations, and health systems. Atul Butte receives royalty payments through Stanford University, for several patents and other disclosures licensed to NuMedii and Personalis. Atul Butte’s research has been funded by NIH, Northrup Grumman (as the prime on an NIH contract), Genentech, Johnson and Johnson, FDA, Robert Wood Johnson Foundation, Leon Lowenstein Foundation, Intervalien Foundation, Priscilla Chan and Mark Zuckerberg, the Barbara and Gerson Bakar Foundation, and in the recent past, the March of Dimes, Juvenile Diabetes Research Foundation, California Governor’s Office of Planning and Research, California Institute for Regenerative Medicine, L’Oreal, and Progenity. 3.The above organizations had no direct involvement in study design in the collection, analysis, and interpretation of data in the writing of the report or in the decision to submit the article for publication. 4.The remainder of authors declare no conflicts of interest.
High-dose preoperative glucocorticoid for prevention of emergence and postoperative delirium in liver resection: A double-blinded randomized clinical trial substudy	Awada, H. N. Steinthorsdottir, K. J. Schultz, N. A. Hillingsø, J. G. Larsen, P. N. Jans, Ø Kehlet, H. Aasvang, E. K.	Acta Anaesthesiol Scand	2022	emergence liver resection postoperative delirium preoperative glucocorticoid
Grip strength as a predictor of postoperative delirium in patients with colorectal cancers	Arita, A. Takahashi, H. Ogino, T. Miyoshi, N. Uemura, M. Akasaka, H. Sugimoto, K. Rakugi, H. Doki, Y. Eguchi, H.	Ann Gastroenterol Surg	2022	colorectal cancer grip strength postoperative delirium
Positive scores on the 4AT delirium assessment tool at hospital admission are linked to mortality, length of stay and home time: two-centre study of 82,770 emergency admissions	Anand, A. Cheng, M. Ibitoye, T. Maclullich, A. M. J. Vardy, Erlc	Age Ageing	2022	4 ‘A’s Test (4AT) delirium dementia emergency department (ED) geriatrics hospitalisation older people
Barriers to completing the 4AT for delirium and its clinical implementation in two hospitals: a mixed-methods study	Alhaidari, A. A. O. Matsis, K. P.	Eur Geriatr Med	2022	Aged Delirium/diagnosis/epidemiology/therapy Female Hospitalization Hospitals Humans Male Retrospective Studies Delirium Guideline adherence Hospitals Implementation science New Zealand
The quality of palliative sedation in end-stage disease: audit from a department of oncology and haematology	Alessia, S. Matilde, S. F. Chrystel, I. Massimiliano, S. Daniele, D. Claudia, F. Raffaella, P. Flavia, C. Leonardo, F. Chiara, C. Leonardo, P. Massimo, D. Mario, L. Giuseppe, L.	Support Care Cancer	2022	Conscious Sedation/methods Deep Sedation/methods Hematology Humans Hypnotics and Sedatives/therapeutic use Medical Oncology Midazolam Neoplasms/therapy Palliative Care/methods Terminal Care/methods D-PaP score End-stage disease Palliative sedation Refractory symptoms Rudkin score
Delirium risk in geriatric hip hemi-arthroplasty (DRIGHA): Development and validation of a novel score using a national data	Ahmed, N. Kuo, Y. H.	Injury	2022	Aged Delirium/epidemiology/etiology/prevention & control Hemiarthroplasty/adverse effects *Hip Fractures Humans Incidence Male Postoperative Complications/epidemiology/surgery Risk Factors Delirium Geriatric Hemiarthroplasty Hip fracture
Postoperative delirium and its relationship with biomarkers for dementia: a meta-analysis	Wang, S. Greene, R. Song, Y. Chan, C. Lindroth, H. Khan, S. Rios, G. Sanders, R. D. Khan, B.	Int Psychogeriatr	2022	Alzheimer’s disease biomarkers delirium inflammation postoperative delirium
The association between midazolam premedication and postoperative delirium - a retrospective cohort study	Zarour, S. Weiss, Y. Kiselevich, Y. Iacubovici, L. Karol, D. Shaylor, R. Davydov, T. Matot, I. Cohen, B.	J Clin Anesth	2023	Anesthesia, Elderly, Midazolam, Postoperative delirium
Effects of perioperative intravenous glucocorticoids on perioperative neurocognitive disorders in adults after surgery: A PRISMA-compliant meta-analysis of randomized controlled trials	Wang, F. Hao, X. Zhu, Y.	Medicine (Baltimore)	2023	Humans, Adult, Adolescent, Glucocorticoids, Randomized Controlled Trials as Topic, Administration, Intravenous, Hip Fractures, Neurocognitive Disorders
Association between emergency department modifiable risk factors and subsequent delirium among hospitalized older adults	Oliveira, J. E. Silva L. Stanich, J. A. Jeffery, M. M. Lindroth, H. L. Miller, D. M. Campbell, R. L. Rabinstein, A. A. Pignolo, R. J. Bellolio, F.	Am J Emerg Med	2022	Acute brain failure Delirium Geriatric emergency medicine Geriatrics Older adults
Practices in sedation, analgesia, mobilization, delirium, and sleep deprivation in adult intensive care units (SAMDS-ICU): an international survey before and during the COVID-19 pandemic	Luz, M. Brandão Barreto, B. de Castro, R. E. V. Salluh, J. Dal-Pizzol, F. Araujo, C. De Jong, A. Chanques, G. Myatra, S. N. Tobar, E. Gimenez-Esparza Vich, C. Carini, F. Ely, E. W. Stollings, J. L. Drumright, K. Kress, J. Povoa, P. Shehabi, Y. Mphandi, W	Ann Intensive Care	2022	Analgesia Covid-19 Delirium Mobilization Sedation Sleep deprivation
Mental capacity legislation and communication disability: A cross-sectional survey exploring the impact of the COVID-19 pandemic on the provision of specialist decision-making support by UK SLTs	Jayes, M. Borrett, S. Bose, A.	Int J Lang Commun Disord	2022	Adult covid-19 Communication Disorders/epidemiology/therapy Cross-Sectional Studies Humans Language Therapy Pandemics SARS-CoV-2 Speech Therapy United Kingdom COVID-19, decision-making, disability, mental capacity, speech and language therapists adults
Delirium and Associated Factors in a Cohort of Hospitalized Patients With Coronavirus Disease 2019	García-Grimshaw, M. Chiquete, E. Jiménez-Ruiz, A. Vidal-Mayo, J. J. Grajeda-González, S. L. Vargas-Martínez, MlÁ Toapanta-Yanchapaxi, L. N. Valdés-Ferrer, S. I. Chávez-Martínez, O. A. Marché-Fernández, O. A. Jiménez-Ávila, A. I. Cantú-Brito,	J Acad Consult Liaison Psychiatry	2022	Adult covid-19 Delirium/epidemiology Female Humans Male Middle Aged Pandemics Retrospective Studies SARS-CoV-2 SARS-CoV-2 cohort study coronavirus delirium *hospitalization
Inpatient Diagnosis of Delirium and Encephalopathy: Coding Trends in 2011-2018	Franks, J. A. Anderson, J. L. Bowman, E. Li, C. Y. Kennedy, R. E. Yun, H.	J Acad Consult Liaison Psychiatry	2022	Dsm Icd delirium encephalopathy
Effectiveness of combined non-pharmacological interventions in the prevention of delirium in critically ill patients: A randomized clinical trial	Faustino, T. N. Suzart, N. A. Rabelo, Rnds Santos, J. L. Batista, G. S. Freitas, Y. S. Saback, D. A. Sales, Nmmd Brandao Barreto, B. Gusmao-Flores, D.	J Crit Care	2022	Critical Care Delirium prevention Intensive Care Unit Non-pharmacological interventions Randomized controlled trial interests.
Combined cerebral and somatic near-infrared spectroscopy oximetry monitoring during liver surgery: an observational and non-interventional study	Collin, Y. Hu, T. Denault, A. Fortier, A. Beaubien-Souligny, W. Lapointe, R. Vandenbroucke-Menu, F.	Korean J Anesthesiol	2022	Hepatectomy Intraoperative Liver Monitoring Oximetry Saturation
Characteristics and Outcome Determinants of Hospitalized Older Patients with Cognitive Dysfunction	Chao, Y. T. Kuo, F. H. Lee, Y. S. Huang, Y. H. Weng, S. C. Chou, Y. Y. Lin, C. S. Lin, S. Y.	Int J Environ Res Public Health	2022	Activities of Daily Living Aged Cognition Disorders/epidemiology Cognitive Dysfunction/epidemiology Hospitalization Humans Inpatients activity of daily living cognitive impairment dementia geriatric assessment length of stay readmission
Delirium in hospitalized patients with COVID-19 pneumonia: a prospective, cross-sectional, cohort study	Callea, A. Conti, G. Fossati, B. Carassale, L. Zagaria, M. Caporotundo, S. Ziglioli, E. Brunetti, V. Della Marca, G. Rollo, E.	Intern Emerg Med	2022	Covid-19 Comfortable care Delirium Frailty Helmet-CPAP
Association of perioperative midazolam use and complications: a population-based analysis	Athanassoglou, V. Cozowicz, C. Zhong, H. Illescas, A. Poeran, J. Liu, J. Poultsides, L. Memtsoudis, S. G.	Reg Anesth Pain Med	2022	analgesia anesthesia conduction epidemiology
Best practices to prevent delirium in hospitalised patients	Yerra, S. Yarra, P.	Evid Based Nurs	2022	Delirium/prevention & control Humans Intensive Care Units adult intensive & critical care delirium & cognitive disorders nursing *protocols & guidelines
Inhalational Versus Propofol-based Intravenous Maintenance of Anesthesia for Emergence Delirium in Adults: A Meta-analysis and Trial Sequential Analysis	Yang, Y. Feng, L. Ji, C. Lu, K. Chen, Y. Chen, B.	J Neurosurg Anesthesiol	2022
Role of interleukin-18 in postoperative delirium: an exploratory analysis	Wu, J. G. Taylor, J. Parker, M. Kunkel, D. Rivera, C. Pearce, R. A. Lennertz, R. Sanders, R. D.	Br J Anaesth	2022	delirium inflammation interleukin-18 postoperative surgery
Effect of general anesthesia with thoracic paravertebral block on postoperative delirium in elderly patients undergoing thoracoscopic lobectomy: a randomized-controlled trial	Wei, W. Zheng, X. Gu, Y. Fu, W. Tang, C. Yao, Y.	BMC Anesthesiol	2022	Postoperative delirium Postoperative quality of recovery Thoracic paravertebral block Video-assisted thoracoscopic lobectomy
Probable Delirium and Associated Patient Characteristics in Long-Term Care and Complex Continuing Care: A Population-Based Observational Study	Webber, C. Watt, C. L. Bush, S. H. Lawlor, P. G. Knoefel, F. Momoli, F. Thavorn, K. Casey, G. Tanuseputro, P.	J Am Med Dir Assoc	2022	Cross-Sectional Studies Delirium/diagnosis/epidemiology Humans Long-Term Care Ontario/epidemiology Prevalence Delirium complex continuing care continuing care prevalence *risk factors
Postoperative delirium and its relationship with biomarkers for dementia: a meta-analysis	Wang, S. Greene, R. Song, Y. Chan, C. Lindroth, H. Khan, S. Rios, G. Sanders, R. D. Khan, B.	Int Psychogeriatr	2022	Alzheimer’s disease biomarkers delirium inflammation postoperative delirium
Melatonin and melatonergic agents for the prevention of postoperative delirium: A meta-analysis of randomized placebo-controlled trials	Wang, C. M. Zhou, L. Y.	Asian J Surg	2022	Adult Aged Anesthesia, General Delirium/prevention & control Humans Incidence Melatonin/therapeutic use Randomized Controlled Trials as Topic Delirium Melatonin Meta-analysis
Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia	Valent, A. Carval, A. Cattan, P. Plaud, B.	Eur J Anaesthesiol	2022	Aged Anesthesia, General Anesthesia, Intravenous Delirium/chemically induced/diagnosis/prevention & control Dexmedetomidine/adverse effects Esophagectomy/adverse effects Humans
Transfusion-Associated Delirium in Children: No Difference Between Short Storage Versus Standard Issue RBCs	Traube, C. Tucci, M. Nellis, M. E. Avery, K. L. McQuillen, P. S. Fitzgerald, J. C. Muszynski, J. A. Cholette, J. M. Schwarz, A. J. Stalets, E. L. Quaid, M. A. Hanson, S. J. Lacroix, J. Reeder, R. W. Spinella, P. C.	Crit Care Med	2022
Pediatric Delirium: We Have Come a Long Way, and We Have Only Just Begun	Traube, C.	Crit Care Med	2022
Beware the Aftermath: Delirium and Post-Intensive Care Syndrome in Critically Ill Children	Traube, C.	Pediatr Crit Care Med	2022
Amyloid deposition on positron emission tomography correlates with severity of perioperative delirium: a case-control pilot study	Torres-Velázquez, M. Parker, M. Bo, A. White, M. Tanabe, S. Pearce, R. A. Lennertz, R. Cho, S. Y. Bendlin, B. Johnson, S. C. Prabhakaran, V. McMillan, A. B. Sanders, R. D.	Br J Anaesth	2022	amyloid delirium neurodegeneration positron emission tomography postoperative complications surgery
VE-CAM-S: Visual EEG-Based Grading of Delirium Severity and Associations With Clinical Outcomes	Tesh, R. A. Sun, H. Jing, J. Westmeijer, M. Neelagiri, A. Rajan, S. Krishnamurthy, P. V. Sikka, P. Quadri, S. A. Leone, M. J. Paixao, L. Panneerselvam, E. Eckhardt, C. Struck, A. F. Kaplan, P. W. Akeju, O. Jones, D. Kimchi, E. Y. Westover, M. B.	Crit Care Explor	2022	Eeg delirium delirium severity encephalopathy prognosis
KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients	Terrelonge, M. LaHue, S. C. Tang, C. Movsesyan, I. Pullinger, C. R. Dubal, D. B. Leung, J. Douglas, V. C.	Sci Rep	2022
Pilot Study of Lemborexant for Insomnia in Cancer Patients with Delirium	Terada, T. Hirayama, T. Sadahiro, R. Wada, S. Nakahara, R. Matsuoka, H.	J Palliat Med	2022	cancer patients delirium insomnia lemborexant orexin receptor antagonist
Managing agitation secondary to hyperactive delirium in deteriorating patients	Teece, A.	Nurs Stand	2022	Delirium/etiology Humans Intensive Care Units Length of Stay Psychomotor Agitation Restraint, Physical agitation clinical control and restraint critical care delirium intensive care mental health nursing care professional signs and symptoms symptom management
Incidence of Delirium With Different Oral Opioids in Previously Opioid-Naive Patients	Sugiyama, Y. Tanaka, R. Sato, T. Sato, T. Saitoh, A. Yamada, D. Shino, M.	Am J Hosp Palliat Care	2022	concomitant drugs delirium morphine oral opioids oxycodone tapentadol
Adult behavior toward the child before surgery and pediatric emergence delirium	Sobol, M. Sobol, M. K. Kowal, M.	Paediatr Anaesth	2022	Adult Anesthesia Recovery Period Anesthesia, General Child *Emergence Delirium/epidemiology Humans Campis-r behavior emergence delirium surgery
Risk Factors for Delirium and Association of Antipsychotic Use with Delirium Progression in Critically Ill Trauma Patients	Shoulders, B. R. Elsabagh, S. Tam, D. J. Frantz, A. M. Alexander, K. M. Voils, S. A.	Am Surg	2022	antipsychotic delirium intensive care unit risk factors trauma
Incidence and Risk Factors of Ventilator-Associated Pneumonia among Patients with Delirium in the Intensive Care Unit: A Prospective Observational Study	Shamsizadeh, M. Fathi Jouzdani, A. Rahimi-Bashar, F.	Crit Care Res Pract	2022
Delirium in older adults, if you think it's the urine, think again	Schonnop, R. Woods, R. Ellis, B.	Cjem	2022
The detection of delirium in admitted oncology patients: a scoping review	Sands, M. B. Wee, I. Agar, M. Vardy, J. L.	Eur Geriatr Med	2022	Cancer Delirium Detection Inpatient Oncology Screening
Delirium in the Context of Zonisamide-Induced Toxic Epidermal Necrolysis	Reinfeld, S. Tejeda, C. I. Koola, M. M.	Prim Care Companion CNS Disord	2022
Prevalence of Delirium in End-of-life Palliative Care Patients: An Observational Study	Recchia, A. Rizzi, B. Favero, A. Nobili, A. Pasina, L.	Med Princ Pract	2022
Hospitalizations of older people in an emergency department related to potential medication-induced hyperactive delirium: a cross-sectional study	Raso, J. Santos, L. M. C. Reis, D. A. Frangiotti, M. A. C. Zanetti, A. C. B. Capucho, H. C. Herdeiro, M. T. Roque, F. Pereira, L. R. L. Varallo, F. R.	Int J Clin Pharm	2022	Aged Delirium Drug therapy Emergency service, hospital Risk factors
Clinical Significance of Delirium With Catatonic Signs in Patients With Neurological Disorders	Ramirez-Bermudez, J. Medina-Gutierrez, A. Gomez-Cianca, H. Arias, P. Pérez-Gonzalez, A. Lebrija-Reyes, P. A. Espinola-Nadurille, M. Aguilar-Venegas, L. C. Ojeda-López, C. Restrepo-Martínez, M. Bayliss, L. Juárez-Jaramillo, C. A. Peñaloza, G. Rivas-Al	J Neuropsychiatry Clin Neurosci	2022	Catatonia Delirium
Patient perspectives on delirium and cognitive dysfunction after surgery: a cross-sectional survey	Ragheb, J. Khatibi, N. McKinney, A. Brooks, J. Hill-Carruthers, M. Vlisides, P. E.	Br J Anaesth	2022	cognitive dysfunction delirium neurocognitive disorders patient participation survey
Association between delirium and cognitive impairment: there is a link?	Pistacchi, M. Gioulis, M. Marsala, S. Z.	Curr Alzheimer Res	2022	Cognitive Impairment Delirium Subtype Dementia Screening Population encephalopathy neurodegenerative diseases
Utility of white matter disease and atrophy on routinely acquired brain imaging for prediction of long-term delirium risk: population-based cohort study	Pendlebury, S. T. Thomson, R. J. Welch, S. J. V. Kuker, W. Rothwell, P. M.	Age Ageing	2022	Atrophy/pathology Brain/diagnostic imaging/pathology Cohort Studies Delirium/diagnostic imaging/epidemiology Humans Ischemic Attack, Transient/pathology Leukoencephalopathies/pathology Magnetic Resonance Imaging Neuroimaging Stroke White Matter/diagnostic imaging/pathology brain imaging delirium older people *transient ischemic attack (TIA)
Massachusetts Intensive Care Unit Nurses From Multiple Hospitals Develop a Collaborative to Improve Delirium Assessment Accuracy	O'Donoghue, S. C. Meyers, K. Manning, C. R. Pellegrino, L. S. Ryan, C. P. Crowell, A. M. Nolan, L. M. Gallagher, G. E.	Dimens Crit Care Nurs	2022	Critical Care Delirium/diagnosis Hospitals Humans Intensive Care Units Nurses
Incidence and factors associated with postoperative delirium in patients undergoing transurethral resection of bladder tumor	Nakatani, S. Ida, M. Wang, X. Naito, Y. Kawaguchi, M.	JA Clin Rep	2022	Age Body mass index General anesthesia Postoperative delirium Tur-bt
Association of Nutritional Status with New-Onset Delirium in Elderly, Acute Care, Orthopaedic Trauma Patients: A Single-Center Observational Study	Maher, S. S. Franco-Garcia, E. Zhou, C. Heng, M. van Pelt, M. Akeju, O. Quraishi, S. A.	J Orthop Trauma	2022	Aged Cross-Sectional Studies Delirium/diagnosis/epidemiology Geriatric Assessment Humans Malnutrition Nutritional Status *Orthopedics Retrospective Studies
Efficacy of EWINDOW for prevention of delirium at intensive care units: A protocol for systematic review and meta-analysis	Liu, J. Wang, J.	Medicine (Baltimore	2022	delirium, EWINDOW, intensive care units
Delirium and subsyndromal delirium are associated with the long-term risk of death after ischaemic stroke	Klimiec-Moskal, E. Slowik, A. Dziedzic, T.	Aging Clin Exp Res	2022	Delirium Mortality Stroke Subsyndromal delirium
An innovative post-hospital model of care (DDEFY Delirium): A pilot randomized trial	Khan, A. Uribe-Cano, D. Klumph, M. Simpson, M. Macias Tejada, J. Galambos, C. Hubatch, S. Malone, M. L.	J Am Geriatr Soc	2022
Impact of postanesthesia care unit delirium on self-reported cognitive function and perceived health status: a prospective observational cohort study	Kainz, E. Stuff, K. Kahl, U. Wiessner, C. Yu, Y. von Breunig, F. Nitzschke, R. Haese, A. Graefen, M. Fischer, M.	Qual Life Res	2022	Anesthesia recovery period Cognitive dysfunction Delirium Perceived health status Postoperative cognitive complications Prostatectomy Quality of life
Can multifaceted educational intervention improve clinical practice and patient outcomes regarding delirium in nursing homes?	Jeong, E. Chang, S. O	Jpn J Nurs Sci	2022	Aged Delirium/diagnosis Health Personnel Humans Nursing Homes Nursing Staff, Hospital delirium intervention
Does Preoperative Cognitive Optimization Improve Postoperative Outcomes in the Elderly?	Ishizawa, Y.	J Clin Med	2022	advanced age cognitive training perioperative neurocognitive disorder postoperative delirium preoperative optimization
Postoperative Delirium in Lung Cancer Anatomical Resection-Analysis of Risk Factors and Prognosis	Ishibashi, H. Wakejima, R. Asakawa, A. Sugita, Y. Ishikawa, Y. Hanafusa, M. Baba, S. Nakashima, Y. Seto, K. Okubo, K.	World J Surg	2022
Preoperative Risk Factors and Early Outcomes of Delirium in Valvular Open-Heart Surgery	Hulde, N. Zittermann, A. Tigges-Limmer, K. Koster, A. Weinrautner, N. Gummert, J. von Dossow, V.	Thorac Cardiovasc Surg	2022
Plasma 5-HIAA activity indicative of serotonergic disturbances in cognitively impaired, elderly patients experiencing postoperative delirium	Heylen, A. Vermeiren, Y. De Rooij, S. E. Scholtens, R. M. Van Munster, B. C. Van Dam, D. De Deyn, P. P.	Int J Geriatr Psychiatry	2022	Aged Cognition Delirium Humans Hydroxyindoleacetic Acid hplc uplc ageing biogenic amines biomarker cognitive impairment monoamine neurotransmitters
Depression, Delirium and Post-Intensive Care Syndrome	Garcez-Leme, L. E. Avelino-Silva, T. J.	Int Psychogeriatr	2022
Usefulness of Preoperative Controlling Nutritional Status in Predicting Prolonged Hospitalization and Incidence of Postoperative Delirium for Elderly Hepatectomy with Hepatocellular Carcinoma	Fujio, A. Usuda, M. Hara, Y. Kakizaki, Y. Okada, K. Miyata, G. Unno, M. Kamei, T.	Tohoku J Exp Med	2022	Aged Carcinoma, Hepatocellular/epidemiology/surgery Delirium/epidemiology Hepatectomy/adverse effects Hospitalization Humans Incidence *Liver Neoplasms/epidemiology/surgery Nutritional Status Postoperative Complications/epidemiology Prognosis Retrospective Studies controlling nutritional status delirium elderly patients hepatectomy hepatocellular carcinoma
Inpatient Diagnosis of Delirium and Encephalopathy: Coding Trends 2011-2018	Franks, J. A. Anderson, J. L. Bowman, E. Li, C. Y. Kennedy, R. E. Yun, H.	J Acad Consult Liaison Psychiatry	2022	Dsm Icd delirium encephalopathy
Barriers and facilitators to nursing delirium screening in older emergency patients: a qualitative study using the theoretical domains framework	Eagles, D. Cheung, W. J. Avlijas, T. Yadav, K. Ohle, R. Taljaard, M. Molnar, F. Stiell, I. G.	Age Ageing	2022	Aged Delirium/diagnosis Emergency Service, Hospital Humans Mass Screening Qualitative Research delirium emergency department older people qualitative study *screening
The evidence for introducing case-finding for delirium and dementia in older medical inpatients in a New Zealand hospital	Cullum, S. Kubba, Y. Varghese, C. Coomarasamy, C. Hopkins, J.	Australas Psychiatry	2022	case-finding delirium dementia general hospital screening
Pediatric delirium in times of COVID-19	Castro, R. E. V. Rodríguez-Rubio, M. Magalhães-Barbosa, M. C. Prata-Barbosa, A.	Rev Bras Ter Intensiva	2022	covid-19 Child Delirium/diagnosis Humans SARS-CoV-2
Accuracy of delirium risk factors in adult intensive care unit patients	Carvalho, L. A. C. Correia, M. D. L. Ferreira, R. C. Botelho, M. L. Ribeiro, E. Duran, E. C. M.	Rev Esc Enferm USP	2022	Adult *Delirium/diagnosis/epidemiology Hospitalization Humans Intensive Care Units Male Prospective Studies Risk Factors
The management of delirium in the older adult in advanced nursing practice	Carey, E. Furlong, E. Smith, R.	Br J Nurs	2022	Advanced Practice Nursing Aged Delirium/diagnosis Humans *Nursing Care Advanced nursing practice Delirium Differential diagnosis Older adult Older person
Postoperative Delirium: The Search for Effective Interventions	Campbell, D. Short, T. G. Chan, M. T. V.	J Neurosurg Anesthesiol	2022
Confusion and Representative Restraint: An Exercise in Clinical Reasoning	Bushunow, V. Klein, A. Follansbee, W. Bonifacino, E.	J Gen Intern Med	2022	Clinical Reasoning Confusion/etiology Exercise Humans Restraint, Physical
Psychoactive medication therapy and delirium screening in skilled nursing facilities	Briesacher, B. A. Olivieri-Mui, B. L. Koethe, B. Saczynski, J. S. Fick, D. M. Devlin, J. W. Marcantonio, E. R.	J Am Geriatr Soc	2022	delirium dementia prescribing skilled-nursing facilities
Comparison of delirium detection tools in acute care : A rapid review	Brefka, S. Eschweiler, G. W. Dallmeier, D. Denkinger, M. Leinert, C.	Z Gerontol Geriatr	2022	4As test Assessment Confusion assessment method Practicability Screening
Implications of the COVID-19 pandemic: Virtual nursing education for delirium care	Bourgault, A. Mayerson, E. Nai, M. Orsini-Garry, A. Alexander, I. M.	J Prof Nurs	2022	covid-19 Delirium Education, Nursing Humans Pandemics SARS-CoV-2 Students, Nursing Covid-19 Clinical experience Delirium Nursing education Technology Virtual simulation
Postoperative delirium prediction using machine learning models and preoperative electronic health record data	Bishara, A. Chiu, C. Whitlock, E. L. Douglas, V. C. Lee, S. Butte, A. J. Leung, J. M. Donovan, A. L.	BMC Anesthesiol	2022	Delirium prevention Geriatric surgery Machine learning Postoperative delirium *Risk prediction model
Association between nonpharmacological strategies and delirium in intensive care unit	Bersaneti, M. D. R. Whitaker, I. Y.	Nurs Crit Care	2022	caregivers critical care nursing delirium intensive care units physical restraint
Differential Effects of Gamma-Aminobutyric Acidergic Sedatives on Risk of Post-Extubation Delirium in the ICU: A Retrospective Cohort Study From a New England Health Care Network	Azimaraghi, O. Wongtangman, K. Wachtendorf, L. J. Santer, P. Rumyantsev, S. Ahn, C. Kiyatkin, M. E. Teja, B. Sarge, T. Subramaniam, B. Eikermann, M.	Crit Care Med	2022	Differential Effects Gamma-Aminobutyric Acidergic Sedatives Risk Post-Extubation Delirium ICU Retrospective Cohort Study
Risk factors for postoperative delirium after cardiac surgical procedures with cardioplegic arrest	Andrási, T. B. Talipov, I. Dinges, G. Arndt, C. Rastan, A. J.	Eur J Cardiothorac Surg	2022	Cabg Cpb Delirium Probability risk calculator Valve/aortic surgery
Delirium screening tools in the post-anaesthetic care unit: a systematic review and meta-analysis	Aldwikat, R. K. Manias, E. Tomlinson, E. Amin, M. Nicholson, P.	Aging Clin Exp Res	2022	Delirium Delirium diagnosis Post-anesthetic recovery unit Screening tools Sensitivity and specificity
Effect of earplug/eye mask on sleep and delirium in intensive care patients	Akpinar, R. B. Aksoy, M. Kant, E.	Nurs Crit Care	2022	delirium earplugs eye mask intensive care unit sleep quality
Inclusion of interleukin-6 improved performance of postoperative delirium prediction for patients undergoing coronary artery bypass graft (POD-CABG): A derivation and validation study	Zhang, S. Ji, M. H. Ding, S. Wu, Y. Feng, X. W. Tao, X. J. Liu, W. W. Ma, R. Y. Wu, F. Q. Chen, Y. L.	J Cardiol	2021	Coronary artery bypass graft surgery Interleukin-6 Postoperative delirium Prediction rule interest
DNA methylation in the TNF-alpha gene decreases along with aging among delirium inpatients	Yamanashi, T. Saito, T. Yu, T. Alario, A. Comp, K. Crutchley, K. J. Sullivan, E. J. Anderson, Z. M. Marra, P. S. Chang, G. Wahba, N. E. Jellison, S. S. Meyer, A. A. Mathur, S. Pandharipande, P. Yoshino, A. Kaneko, K. Lee, S. Toda, H. Iwata, M. Shinozaki,	Neurobiol Aging	2021	Aged Aging/genetics Cohort Studies CpG Islands/genetics DNA Methylation/genetics Delirium/etiology/genetics Female Genome-Wide Association Study/methods High-Throughput Nucleotide Sequencing Humans Inflammation Inpatients Male Tumor Necrosis Factor-alpha/genetics Aging DNA methylation Delirium EPIC array Pyrosequencing *TNF-alpha