What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Impact of propofol versus sevoflurane on the incidence of postoperative delirium in elderly patients after spine surgery: study protocol of a randomized controlled trial | Wang, J. H. Lv, M. Zhang, H. X. Gao, Y. Chen, T. T. Wan, T. T. Wang, Y. L. | Trials | 2022 |
Aged |
| Impact of propofol versus sevoflurane on the incidence of postoperative delirium in elderly patients after spine surgery: study protocol of a randomized controlled trial | Wang, J. H. Lv, M. Zhang, H. X. Gao, Y. Chen, T. T. Wan, T. T. Wang, Y. L. | Trials | 2022 |
Aged |
| Potential Value of Serum Uric Acid in the Identification of Postoperative Delirium in Geriatric Patients Undergoing Knee Replacement | Wang, F. Tang, X. Wang, J. Liu, S. Wu, X. Dong, R. Lin, X. Wang, B. Bi, Y. | Front Aging Neurosci | 2022 |
Alzheimer-related biomarkers |
| Patient Outcomes After Delirium Screening and Incident Alzheimer's Disease or Related Dementias in Skilled Nursing Facilities | Vo, Q. T. Koethe, B. Holmes, S. Simoni-Wastila, L. Briesacher, B. A. | J Gen Intern Med | 2022 |
Alzheimer’s disease |
| Delirium in head trauma: looking for a culprit | Villani, E. R. Franza, L. Cianci, R. | Rev Recent Clin Trials | 2022 |
Delirium |
| Timing, Threshold, and Duration of Intraoperative Hypotension in Cardiac Surgery: Their Associations With Postoperative Delirium | Ushio, M. Egi, M. Fujimoto, D. Obata, N. Mizobuchi, S. | J Cardiothorac Vasc Anesth | 2022 |
Cardiac valvular surgery |
| Detecting delirium in nursing home residents using the Informant Assessment of Geriatric Delirium (I-AGeD): a validation pilot study | Urfer Dettwiler, P. Zúñiga, F. Bachnick, S. Gehri, B. de Jonghe, J. F. M. Hasemann, W. | Eur Geriatr Med | 2022 |
Aged |
| Association of preoperative frailty and postoperative delirium in older cancer patients undergoing elective abdominal surgery: a prospective observational study in Taiwan | Tsai, C. Y. Liu, K. H. Lai, C. C. Hsu, J. T. Hsueh, S. W. Hung, C. Y. Yeh, K. Y. Hung, Y. S. Lin, Y. C. Chou, W. C. | Biomed J | 2022 |
cancer |
| Delirium and Cortical Complexity: Divergent Changes in Alpha and Theta Bands | Tanabe, S. Parker, M. Lennertz, R. Pearce, R. A. Banks, M. I. Sanders, R. D. | J Gerontol A Biol Sci Med Sci | 2022 | |
| Escaping delirium: Designing an escape room active learning experience for geriatric resource nurses | Stoller, A. Iannuzzo, S. Davis, K. | Geriatr Nurs | 2022 |
Creative problem solving |
| Perivascular spaces visible on magnetic resonance imaging predict subsequent delirium in older patients | Song, Q. Zhao, Y. Lin, T. Yue, J. | Front Aging Neurosci | 2022 |
cerebral small vessel disease |
| Postoperative delirium does not affect cardiopulmonary exercise testing in aged patients undergoing cardiac valve surgery | Shimomoto, Y. Mukaiyama, K. Hori, T. Inaki, Y. Masai, T. Hayashi, Y. | JA Clin Rep | 2022 |
Cardiac rehabilitation |
| Silent cerebral ischemia detected by magnetic resonance imaging can predict postoperative delirium after total arch replacement for aneurysm | Shibagaki, K. Shirasaka, T. Sawada, J. Saijo, Y. Kunioka, S. Kikuchi, Y. Kamiya, H. | JTCVS Open | 2022 |
AAA, aortic arch aneurysm |
| Impact of delirium on the outcome of stroke: a prospective, observational, cohort study | Rollo, E. Brunetti, V. Scala, I. Callea, A. Marotta, J. Vollono, C. Frisullo, G. Broccolini, A. Calabresi, P. Della Marca, G. | J Neurol | 2022 |
Delirium |
| Association between non-English language and use of physical and chemical restraints among medical inpatients with delirium | Reppas-Rindlisbacher, C. Shin, S. Purohit, U. Verma, A. Razak, F. Rochon, P. Sheehan, K. Rawal, S. | J Am Geriatr Soc | 2022 | |
| Sedation, analgesia, and delirium management in Portugal: a survey and point prevalence study | Paulino, M. C. Pereira, I. J. Costa, V. Neves, A. Santos, A. Teixeira, C. M. Coimbra, I. Fernandes, P. Bernardo, R. Póvoa, P. Granja, C. | Rev Bras Ter Intensiva | 2022 |
*Analgesia |
| Acute kidney injury-associated delirium: a review of clinical and pathophysiological mechanisms | Pang, H. Kumar, S. Ely, E. W. Gezalian, M. M. Lahiri, S. | Crit Care | 2022 |
*Acute Kidney Injury |
| Delirium Development After Lung Transplantation: An Intraoperative Assessment | Ozay, H. Y. Bindal, M. Turkkan, S. Beyoglu, M. A. Yekeler, E. Turan, S. | Transplant Proc | 2022 | |
| Delirium severity does not differ between medical and surgical intensive care units after adjusting for medication use | Ortiz, D. Lindroth, H. L. Braly, T. Perkins, A. J. Mohanty, S. Meagher, A. D. Khan, S. H. Boustani, M. A. Khan, B. A. | Sci Rep | 2022 |
Activities of Daily Living |
| Risk factors for postoperative delirium on oxygen delivery-guided perfusion | Mukaida, H. Matsushita, S. Minami, Y. Sato, G. Usuba, M. Kondo, R. Asai, T. Amano, A. | J Cardiothorac Surg | 2022 |
Cardiopulmonary Bypass/adverse effects/methods |
| Identifying Medicare Beneficiaries With Delirium | Moura, Lmvr Zafar, S. Benson, N. M. Festa, N. Price, M. Donahue, M. A. Normand, S. L. Newhouse, J. P. Blacker, D. Hsu, J. | Med Care | 2022 | |
| The development of a web-based app employing machine learning for delirium prevention in long-term care facilities in South Korea | Moon, K. J. Son, C. S. Lee, J. H. Park, M. | BMC Med Inform Decis Mak | 2022 |
*Delirium/diagnosis/prevention & control |
| Impact of Family Presence on Delirium in Critically Ill Patients: A Retrospective Cohort Study | Mohsen, S. Moss, S. J. Lucini, F. Krewulak, K. D. Stelfox, H. T. Niven, D. J. Sauro, K. M. Fiest, K. M. | Crit Care Med | 2022 | |
| Serum levels of apolipoprotein A-I and E are associated with postoperative delirium: A post hoc analysis | Mietani, K. Hasegawa-Moriyama, M. Inoue, R. Ogata, T. Shimojo, N. Kurano, M. Yatomi, Y. Uchida, K. Sumitani, M. | Medicine (Baltimore) | 2022 |
Aged |
| Staff training and the use of rapid, accurate and user-friendly tools for delirium screening could improve the diagnosis of delirium in the elderly referred to the emergency department | Mazzola, P. Spedale, V. | Evid Based Nurs | 2022 |
evidence-based nursing |
| Current practice of pharmacological treatment for hyperactive delirium in terminally ill cancer patients: results of a nationwide survey of Japanese palliative care physicians and liaison psychiatrists | Matsuda, Y. Morita, T. Oya, K. Tagami, K. Naito, A. S. Kashiwagi, H. Otani, H. | Jpn J Clin Oncol | 2022 |
*Antipsychotic Agents/therapeutic use |
| Higher serum PGE2 is a predicative biomarker for postoperative delirium following elective orthopedic surgery in elderly patients | Mao, M. Wang, L. Y. Zhu, L. Y. Wang, F. Ding, Y. Tong, J. H. Sun, J. Sun, Q. Ji, M. H. | BMC Geriatr | 2022 |
Aged |
| Effect of acute pain on the association between preoperative cognitive impairment and postoperative delirium: a secondary analysis of three trials | Ma, J. H. Liu, Y. F. Hong, H. Li, C. J. Cui, F. Mu, D. L. Wang, D. X. | Br J Anaesth | 2022 |
cognitive dysfunction |
| A systematic review of modified electroconvulsive therapy (ECT) to treat delirium | Lupke, K. Warren, N. Teodorczuk, A. Steele, S. Kolur, U. Wand, A. Robinson, G. Parker, S. | Acta Psychiatr Scand | 2022 |
acute confusion |
| Incidence and interaction factors of delirium as an independent risk of mortality in elderly patients in the intensive units: a retrospective analysis from MIMIC-IV database | Liu, H. Zhao, Q. Liu, X. Hu, X. Wang, L. Zhou, F. | Aging Clin Exp Res | 2022 |
Delirium |
| The effect of neostigmine on postoperative delirium after colon carcinoma surgery: a randomized, double-blind, controlled trial | Liu, F. Lin, X. Lin, Y. Deng, X. Guo, Y. Wang, B. Dong, R. Bi, Y. | BMC Anesthesiol | 2022 |
Adult |
| Outcomes of postoperative delirium in patients undergoing cardiac surgery: A systematic review and meta-analysis | Lin, L. Zhang, X. Xu, S. Peng, Y. Li, S. Huang, X. Chen, L. Lin, Y. | Front Cardiovasc Med | 2022 |
cardiac surgery |
| Non-pharmacological delirium prevention practices among critical care nurses: a qualitative study | Liang, S. Chau, J. P. C. Lo, S. H. S. Zhao, J. Liu, W. | BMC Nurs | 2022 |
Delirium |
| Effect of regional anesthesia on the postoperative delirium: A systematic review and meta-analysis of randomized controlled trials | Li, T. Dong, T. Cui, Y. Meng, X. Dai, Z. | Front Surg | 2022 |
delirium |
| Assessing Delirium at Hospital Discharge | Lepkowsky, C. M. Janklow, H. M. | Am J Geriatr Psychiatry | 2022 |
Delirium |
| The Effects of Pain, Agitation, Delirium, Immobility, and Sleep Disruption Education on Novice Nurses in Adult Intensive Care Units | Lee, S. Y. Liu, C. Y. Wu, T. Y. | Healthcare (Basel) | 2022 |
Padis |
| Treatment of Positive Urine Cultures at End-of-Life and the Effect on Terminal Delirium Management | Latuga, N. M. Grant, P. C. Levy, K. Luczkiewicz, D. L. | Am J Hosp Palliat Care | 2022 |
Anti-Bacterial Agents/therapeutic use |
| Risk factors and effect of postoperative delirium on adverse surgical outcomes in older adults after elective abdominal cancer surgery in Taiwan | Lai, C. C. Liu, K. H. Tsai, C. Y. Hsu, J. T. Hsueh, S. W. Hung, C. Y. Chou, W. C. | Asian J Surg | 2022 |
Cancer surgery |
| A Quality Improvement Study on Delirium Awareness Day: In Pursuit of Missed Delirium Diagnoses | Koca, M. Öztürk, Y. Boğa, İ Bürkük, S. Eşme, M. Akyürek, Y. Şimşek, S. Aydın, D. D. Çiçek, F. Karabulut, E. Halil, M. Cankurtaran, M. Tanrıöver, M. D. Doğu, B. B. | J Gerontol Nurs | 2022 |
Aged |
| Serum C-reactive protein adds predictive information for post-stroke delirium: The PROPOLIS study | Klimiec-Moskal, E. Slowik, A. Dziedzic, T. | Acta Psychiatr Scand | 2022 |
Crp |
| External validation and comparison of two delirium prediction models in patients admitted to the cardiac intensive care unit | Kim, S. E. Ko, R. E. Na, S. J. Chung, C. R. Choi, K. H. Kim, D. Park, T. K. Lee, J. M. Song, Y. B. Choi, J. O. Hahn, J. Y. Choi, S. H. Gwon, H. C. Yang, J. H. | Front Cardiovasc Med | 2022 |
Early PREdiction of DELIRium |
| Delirium and Cortical Complexity | Kim, H. Lee, U. C. Vlisides, P. E. | Delirium and Cortical Complexity | 2022 | |
| Can Variables From the Electronic Health Record Identify Delirium at Bedside? | Khan, A. Heslin, K. Simpson, M. Malone, M. L. | J Patient Cent Res Rev | 2022 |
delirium |
| Thoracic Paravertebral Block Ameliorates Postoperative Delirium in Geriatric Patients | Heng, L. Wang, M. Wang, M. Li, L. Zhu, S. | Thorac Cardiovasc Surg | 2022 |
Aged |
| Relationship of sleep disturbance and postoperative delirium: a systematic review and meta-analysis | He, E. Dong, Y. Jia, H. Yu, L. | Gland Surg | 2022 |
Postoperative delirium (PD) |
| Acceptability of transdermal antipsychotic patches by patients who refuse oral medication and their effectiveness in preventing recurrence of delirium: a retrospective observational study | Hatta, K. Usui, C. Nakamura, H. | Int Clin Psychopharmacol | 2022 | |
| Perioperative Hemodynamic Optimization in Patients at Risk for Delirium - A Randomized-Controlled Trial | Fuest, K. E. Servatius, A. Ulm, B. Schaller, S. J. Jungwirth, B. Blobner, M. Schmid, S. | Front Med (Lausanne) | 2022 |
frailty |
| Proposing a Scientific and Technological Approach to the Summaries of Clinical Issues of Inpatient Elderly with Delirium: A Viewpoint | Frisardi, V. Nicolini, M. Cautero, N. Ghirardelli, R. Davolio, F. Haouili, M. Barani, M. | Healthcare (Basel) | 2022 |
delirium |
| Incidence of Drug-Induced Delirium During Treatment With Antidepressants or Antipsychotics: A Drug Surveillance Report of German-Speaking Countries Between 1993 and 2016 | Friedrich, M. E. Grohmann, R. Rabl, U. Winkler, D. Konstantinidis, A. Engel, R. Seifert, J. Toto, S. Stübner, S. Frey, R. Kasper, S. | Int J Neuropsychopharmacol | 2022 |
Adverse Drug Reaction Reporting Systems |
| The inter-relationship between delirium and dementia: the importance of delirium prevention | Fong, T. G. Inouye, S. K. | Nat Rev Neurol | 2022 | |
| Five-Year Outcomes After Implementing a Pain, Agitation, and Delirium Protocol in a Mixed Intensive Care Unit | Fish, J. T. Baxa, J. T. Draheim, R. R. Willenborg, M. J. Mills, J. C. Sticht, L. A. Hankwitz, J. L. Wells, J. A. Jung, H. S. | J Intensive Care Med | 2022 |
Adult |
| Improving Delirium Assessments in Vanderbilt Pediatric and Pediatric Cardiovascular Intensive Care Units | Eken, H. N. Betters, K. A. Fuchs, D. C. Smith, H. A. B. Williams, S. R. | Pediatr Qual Saf | 2022 | |
| Outcomes in Post-operative Delirium Following Bowel Resection: A Single Center Retrospective Review | Desrochers, R. M. Lynch, L. J. Gates, J. D. Ricaurte, D. Wade, J. T. Dicks, R. S. Keating, J. J. | J Surg Res | 2022 |
Bowel |
| Efficacy and Safety of Remimazolam Besylate versus Dexmedetomidine for Sedation in Non-Intubated Older Patients with Agitated Delirium After Orthopedic Surgery: A Randomized Controlled Trial | Deng, Y. Qin, Z. Wu, Q. Liu, L. Yang, X. Ju, X. Zhang, Y. Liu, L. | Drug Des Devel Ther | 2022 |
Benzodiazepines |
| Delirium, changes in cognitive function, and risk of diagnosed dementia after kidney transplantation | Chu, N. M. Bae, S. Chen, X. Ruck, J. Gross, A. L. Albert, M. Neufeld, K. J. Segev, D. L. McAdams-DeMarco, M. A. | Am J Transplant | 2022 |
clinical research/practice |
| Bispectral Index (BIS) Monitoring and Postoperative Delirium in Elderly Patients Undergoing Surgery: A Systematic Review and Meta-Analysis With Trial Sequential Analysis | Chew, W. Z. Teoh, W. Y. Sivanesan, N. Loh, P. S. Shariffuddin,, II Ti, L. K. Ng, K. T. | J Cardiothorac Vasc Anesth | 2022 |
Bis |
| Delirium prevalence in geriatric emergency department patients: A systematic review and meta-analysis | Chen, F. Liu, L. Wang, Y. Liu, Y. Fan, L. Chi, J. | Am J Emerg Med | 2022 |
Aged |
| Improving quantification of anticholinergic burden using the Anticholinergic Effect on Cognition Scale - a healthcare improvement study in a geriatric ward setting | Balasundaram, B. Ang, W. S. T. Stewart, R. Bishara, D. Ooi, C. H. Li, F. Akram, F. Eu Kwek, A. B. | Australas Psychiatry | 2022 |
Aged |
| The Association of Selective Serotonin Reuptake Inhibitors With Delirium in Critically Ill Adults: A Secondary Analysis of the Bringing to Light the Risk Factors and Incidence of Neuropsychologic Dysfunction in ICU Survivors ICU Study | Austin, C. A. Yi, J. Lin, F. C. Pandharipande, P. Ely, E. W. Busby-Whitehead, J. Carson, S. S. | Crit Care Explor | 2022 |
delirium |
| Parental Education and Delirium Risk after Surgery in Older Adults | Arias, F. Chen, F. Shiff, H. Marcantonio, E. R. Jones, R. N. Schmitt, E. M. Metzger, E. Fong, T. G. Travison, T. G. Inouye, S. K. | Clin Gerontol | 2022 |
Childhood socioeconomic status |
| Informing the standardising of care for prolonged stay patients in the ICU: A scoping review of quality improvement tools | Allum, L. Apps, C. Pattison, N. Connolly, B. Rose, L. | Intensive Crit Care Nurs | 2022 |
Bundle |
| Monitoring of nighttime EEG slow-wave activity during dexmedetomidine infusion in patients with hyperactive ICU delirium: An observational pilot study | Ala-Kokko, T. Erikson, K. Koskenkari, J. Laurila, J. Kortelainen, J. | Acta Anaesthesiol Scand | 2022 |
C-trend |
| Development of a Delirium Risk Predication Model among ICU Patients in Oman | Al-Hoodar, R. K. Lazarus, E. R. Alomari, O. Alzaabi, O. | Anesthesiol Res Pract | 2022 | |
| Comparison Between Deltascan Single Channel Electroencephalography (EEG), Confusion Assessment Method-Intensive Care Unit (CAM-ICU) Score and Clinical Assessment in Diagnosing Delirium in Intubated Patients in the Intensive Care Unit | Aben, J. Pouwels, S. Oldenbeuving, A. | Cureus | 2022 |
cam-icu |
| A Cross-Sectional Survey on the Clinical Management of Emergence Delirium in Adults: Knowledge, Attitudes, and Practice in Mainland China | Yuan, Y. Lei, B. Li, Z. Wang, X. Zhao, H. Gao, M. Xue, Y. Zhang, W. Xiao, R. Meng, X. Zheng, H. Zhang, J. Wang, G. Guo, X. | Brain Sci | 2022 |
Pacu |
| Development and Validation of a Nomogram for Predicting Postoperative Delirium in Patients With Elderly Hip Fracture Based on Data Collected on Admission | Yang, Y. Wang, T. Guo, H. Sun, Y. Cao, J. Xu, P. Cai, Y. | Front Aging Neurosci | 2022 |
albumin |
| Preoperative Inflammatory Markers and the Risk of Postoperative Delirium in Patients Undergoing Lumbar Spinal Fusion Surgery | Yang, J. S. Lee, J. J. Kwon, Y. S. Kim, J. H. Sohn, J. H. | J Clin Med | 2022 |
CRP-to-albumin ratio |
| An association between cancer type and delirium incidence in Japanese elderly patients: A retrospective longitudinal study | Yamato, K. Ikeda, A. Endo, M. Filomeno, R. Kiyohara, K. Inada, K. Nishimura, K. Tanigawa, T. | Cancer Med | 2022 |
cancer |
| Increased Direct Current-Electroencephalography Shifts During Induction of Anesthesia in Elderly Patients Developing Postoperative Delirium | Windmann, V. Dreier, J. P. Major, S. Spies, C. Lachmann, G. Koch, S. | Front Aging Neurosci | 2022 |
*dc-eeg |
| Risk factors of delirium after gastrointestinal surgery: A meta-analysis | Wang, X. Yu, D. Du, Y. Geng, J. | J Clin Nurs | 2022 |
delirium |
| Physician Experience Design (PXD): More Usable Machine Learning Prediction for Clinical Decision Making | Wang, L. Chignell, M. Zhang, Y. Pinto, A. Razak, F. Sheehan, K. Verma, A. | AMIA Annu Symp Proc | 2022 |
Artificial Intelligence |
| The Relationship Between Cardiovascular Disease Risk Score and Postoperative Delirium: The PNDABLE Study | Wang, J. Wang, L. Tang, X. Wang, F. Liu, S. Wu, X. Dong, R. Lin, X. Wang, B. Bi, Y. | Front Aging Neurosci | 2022 |
biomarkers |
| Preoperative intervention to prevent delirium in patients with hip fracture - a systematic review | Virsøe-Frandsen, C. D. Skjold, C. Wildgaard, K. Møller, A. M. | Dan Med J | 2022 |
Aged |
| Coexisting delirium and excited catatonia | Vellanki, K. D. Carroll, B. T. | Ann Clin Psychiatry | 2022 |
*Antipsychotic Agents/therapeutic use |
| Confusion regarding the use of Natural Language Processing in ICU delirium assessment | van Diem-Zaal, I. J. van den Boogaard, M. Kotfis, K. Ely, E. W. | Intensive Care Med | 2022 |
*Delirium/diagnosis |
| Postoperative delirium and changes in the blood-brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study | Taylor, J. Parker, M. Casey, C. P. Tanabe, S. Kunkel, D. Rivera, C. Zetterberg, H. Blennow, K. Pearce, R. A. Lennertz, R. C. Sanders, R. D. | Br J Anaesth | 2022 |
Biomarkers |
| Prospective clinical intervention study of aripiprazole and risperidone in the management of postoperative delirium in elderly patients after cardiovascular surgery | Sugawara, H. Koyama, A. Maruyama, T. Koda, Y. Fukunaga, H. Ishikawa, T. Takebayashi, M. Okamoto, K. Fukui, T. Hashimoto, M. | Psychiatry Clin Neurosci | 2022 | |
| A simple risk score list can be used to predict the occurrence of delirium in patients admitted to inpatient hospice care: A medical record study | Stoevelaar, R. Juffermans, C. C. M. Roorda, I. M. M. de Nijs, E. J. M. Hoornweg, J. Cannegieter, S. C. van der Linden, Y. M. | Eur J Cancer Care (Engl) | 2022 |
delirium |
| Chemokines in ICU Delirium: An Exploratory Study | Smith, R. J. Rabinstein, A. A. Cartin-Ceba, R. Singh, V. P. Lachner, C. Khatua, B. Trivedi, S. Gajic, O. | Crit Care Explor | 2022 |
chemokine |
| Cytokine profiles in intensive care unit delirium | Smith, R. J. Lachner, C. Singh, V. P. Trivedi, S. Khatua, B. Cartin-Ceba, R. | Acute Crit Care | 2022 |
cytokine |
| Edmonton frailty scale score predicts postoperative delirium: a retrospective cohort analysis | Sieber, F. Gearhart, S. Bettick, D. Wang, N. Y | BMC Geriatr | 2022 |
Cohort Studies |
| Observation of Anesthetic Effect of Dexmedetomidine Combined With Intraspinal Anesthesia in Hip Arthroplasty and its Effect on Postoperative Delirium and Stress Response | Shen, Y. Wang, C. Zhong, X. Wu, Y. He, X. | Front Surg | 2022 |
anesthetic effects |
| Postoperative Application of Dexmedetomidine is the Optimal Strategy to Reduce the Incidence of Postoperative Delirium After Cardiac Surgery: A Network Meta-Analysis of Randomized Controlled Trials | Shang, L. Hou, M. Guo, F. | Ann Pharmacother | 2022 |
cardiac surgery |
| Decreasing delirium through music listening (DDM) in critically ill, mechanically ventilated older adults in the intensive care unit: a two-arm, parallel-group, randomized clinical trial | Seyffert, S. Moiz, S. Coghlan, M. Balozian, P. Nasser, J. Rached, E. A. Jamil, Y. Naqvi, K. Rawlings, L. Perkins, A. J. Gao, S. Hunter, J. D., 3rd Khan, S. Heiderscheit, A. Chlan, L. L. Khan, B. | Trials | 2022 |
Aged |
| Prevention of delirium with agitation by yokukansan in older adults after cancer surgery | Sadahiro, R. Wada, S. Matsuoka, Y. J. Uchitomi, Y. Yamaguchi, T. Sato, T. Esaki, M. Yoshimoto, S. Daiko, H. Kanemitsu, Y. Kawai, A. Kato, T. Fujimoto, H. Uezono, Y. Shimizu, K. Matsuoka, H. | Jpn J Clin Oncol | 2022 |
clinical trial |
| Midazolam impacts acetyl-And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium? | Rump, K. Holtkamp, C. Bergmann, L. Nowak, H. Unterberg, M. Orlowski, J. Thon, P. Bazzi, Z. Bazzi, M. Adamzik, M. Koos, B. Rahmel, T. | PLoS One | 2022 |
Acetylcholinesterase/metabolism |
| Ren, X. Zhang, S. Yang, Y. Song, A. Liang, F. Zhang, Y. Dong, Y. Wu, X. Xie, Z. | Ketamine Induces Delirium-Like Behavior and Interferes With Endosomal Tau Trafficking | Anesth Analg | 2022 | |
| The crucial factors influencing the development and outcomes of postoperative delirium in proximal femur fractures | Rajeev, A. Railton, C. Devalia, K. | Aging Med (Milton) | 2022 |
delirium |
| Neuromonitoring depth of anesthesia and its association with postoperative delirium | Pérez-Otal, B. Aragón-Benedí, C. Pascual-Bellosta, A. Ortega-Lucea, S. Martínez-Ubieto, J. Ramírez-Rodríguez, J. M. | Sci Rep | 2022 |
Anesthesia, General/adverse effects |
| Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care | Pearson, M. Jackson, G. Jackson, C. Boland, J. Featherstone, I. Huang, C. Ogden, M. Sartain, K. Siddiqi, N. Twiddy, M. Johnson, M. | BMJ Open | 2022 |
*Delirium/diagnosis/prevention & control |
| An Interdisciplinary Reappraisal of Delirium and Proposed Subtypes | Oldham, M. A. Slooter, A. J. C. Ely, E. W. Crone, C. Maldonado, J. R. Rosenthal, L. J. | J Acad Consult Liaison Psychiatry | 2022 |
acute encephalopathy |
| Postoperative Delirium in Patients with Oral Cancer: Is Intraoperative Fluid Administration a Neglected Risk Factor? | Obermeier, K. T. Kraus, M. Smolka, W. Henkel, J. Saller, T. Otto, S. Liokatis, P. | Cancers (Basel) | 2022 |
fluid balance |
| Risk of delirium associated with antimuscarinics in older adults: A case-time-control study | Nishtala, P. S. Chyou, T. Y. | Pharmacoepidemiol Drug Saf | 2022 |
Aged |
| Potential effects of regular use of antihypertensive drugs for in-hospital delirium in geriatric patients with trauma | Nagasawa, H. Omori, K. Ota, S. Muramatsu, K. I. Ishikawa, K. Yanagawa, Y. | Sci Rep | 2022 |
Aged |
| Performance of Melatonin as Prophylaxis in Geriatric Patients with Multifactorial Risk for Postoperative Delirium Development: A Randomized Comparative Study | Mohamed, S. A. Rady, A. Youssry, M. Abdelaziz Mohamed, M. R. Gamal, M. | Turk J Anaesthesiol Reanim | 2022 | |
| Perioperative risk factors associated with increased incidence of postoperative delirium: systematic review, meta-analysis, and Grading of Recommendations Assessment, Development, and Evaluation system report of clinical literature | Mevorach, L. Forookhi, A. Farcomeni, A. Romagnoli, S. Bilotta, F. | Br J Anaesth | 2022 |
Grade |
| Delirium in ICU Patients after Cardiac Arrest: A Scoping Review | Mędrzycka-Dąbrowska, W. Lange, S. Religa, D. Dąbrowski, S. Friganović, A. Oomen, B. Krupa, S. | J Pers Med | 2022 |
Icu |
| Epidemiology of delirium in hospitalized patients in Latin America: A systematic review | Maximiliano, B. Sebastian, B. Estefania, A. Irma, C. Gutierrez, P. Daniela, P. Pv Roberta, C. Eduardo, T. Jose, M. Felipe, S. | Acta Psychiatr Scand | 2022 |
Latin America |
| Effect of Perioperative Dexmedetomidine Infusion on Postoperative Delirium in Elderly Patients Undergoing Oral and Maxillofacial Surgery: A Randomized Controlled Clinical Trial | Liu, T. Tuo, J. Wei, Q. Sun, X. Zhao, H. Zhao, X. Qu, M. | Int J Gen Med | 2022 |
dexmedetomidine |
| Type 2 Diabetes Mellitus with Tight Glucose Control and Poor Pre-Injury Stair Climbing Capacity May Predict Postoperative Delirium: A Secondary Analysis | Liu, K. Song, Y. Yuan, Y. Li, Z. Wang, X. Zhang, W. Li, Y. Mi, X. Han, D. Rong, Y. Guo, X. Wang, G. | Brain Sci | 2022 |
glycemic control |