What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Three-Minute Diagnostic Assessment for Delirium using the Confusion Assessment Method (3D-CAM): French translation and cultural adaptation | Gaudet, J. G. Kull, C. Eskenazi, M. L. Diaper, J. Maillard, J. Mollard, F. Marti, C. Marcantonio, E. R. Courvoisier, D. S. Walder, B. | Can J Anaesth | 2022 |
3d-cam |
| Critical role of acute hypoxemia on the cognitive impairment after severe COVID-19 pneumonia: a multivariate causality model analysis | García-Grimshaw, M. Chirino-Pérez, A. Flores-Silva, F. D. Valdés-Ferrer, S. I. Vargas-Martínez, MlÁ Jiménez-Ávila, A. I. Chávez-Martínez, O. A. Ramos-Galicia, E. M. Marché-Fernández, O. A. Ramírez-Carrillo, M. F. Grajeda-González, S. L. Ramí | Neurol Sci | 2022 |
Adolescent |
| Prevalence, risk factors, and outcomes of subsyndromal delirium in older adults in hospital or long-term care settings: A systematic review and meta-analysis | Gao, Y. Gao, R. Yang, R. Gan, X. | Geriatr Nurs | 2022 |
Older adults |
| Hospital-treated deliberate self-poisoning patients: Drug-induced delirium and clinical outcomes | Gale, L. McGill, K. Twaddell, S. Whyte, I. M. Lewin, T. J. Carter, G. L. | Aust N Z J Psychiatry | 2022 |
Aged |
| An Inpatient Geriatrics Program with a Focus on Any Type of Cognitive Impairment Reduces Mortality | Flaherty, J. H. Bloomstone, J. A. Vicents Sande, E. Brantley, A. Semien, G. A. | J Nutr Health Aging | 2022 |
Aged |
| Risk factors for delirium in adult patients receiving specialist palliative care: A systematic review and meta-analysis | Featherstone, I. Sheldon, T. Johnson, M. Woodhouse, R. Boland, J. W. Hosie, A. Lawlor, P. Russell, G. Bush, S. Siddiqi, N. | Palliat Med | 2022 |
Adult |
| Incidence of postoperative delirium in patients with preoperative and postoperative Obstructive Sleep Apnea Syndrome. A Systematic Review of the literature | Dooijeweerd, S. Torensma, B. Faraj, D. Eldawlatly, A. A. | Saudi J Anaesth | 2022 |
Delirium |
| The relationship between body mass index and postoperative delirium | Deng, X. Qin, P. Lin, Y. Tao, H. Liu, F. Lin, X. Wang, B. Bi, Y. | Brain Behav | 2022 |
body mass index |
| Pretransplant physical frailty, postoperative delirium, and short-term outcomes among older lung transplant recipients | Dalton, T. Snyder, L. Buckley, E. B. Smith, P. | Exp Gerontol | 2022 |
Delirium |
| Effects of dexmedetomidine on surgery for type A acute aortic dissection outcome | Cheng, Y. T. Lee, K. T. Chang, C. H. Wu, V. C. Chan, Y. S. Chen, D. Y. Chu, P. H. Chou, A. H. Liu, K. S. Chen, S. W. | Sci Rep | 2022 |
*Acute Kidney Injury/etiology/mortality/therapy |
| Global research trends in perioperative care for the elderly: a bibliometric and visualized study | Chen, Q. Wang, Y. Song, S. Xie, G. Cheng, B. Fang, X. | J Anesth | 2022 |
Aged |
| Assessment of potential selection bias in neuroimaging studies of postoperative delirium and cognitive decline: lessons from the SAGES study | Cavallari, M. Fong, T. G. Touroutoglou, A. Dickerson, B. C. Schmitt, E. Travison, T. G. Marcantonio, E. R. Ngo, L. H. Libermann, T. Pascual-Leone, A. Shafi, M. M. Inouye, S. K. Jones, R. N. | Brain Imaging Behav | 2022 |
Aging |
| Health outcomes after the implementation of multidisciplinary clinical guidelines for the care of hip fractures | Casanova Querol, T. Santiago Bautista, J. M. Lafuente Salinas, M. Güell Farré, E. Girós Torres, J. Martín-Baranera, M. Miralles Basseda, R. | Rev Clin Esp (Barc) | 2022 |
Aged |
| Health outcomes after the implementation of multidisciplinary clinical guidelines for the care of hip fractures | Casanova Querol, T. Santiago Bautista, J. M. Lafuente Salinas, M. Güell Farré, E. Girós Torres, J. Martín-Baranera, M. Miralles Basseda, R. | Rev Clin Esp (Barc) | 2022 |
Aged |
| Health outcomes after the implementation of multidisciplinary clinical guidelines for the care of hip fractures | Casanova Querol, T. Santiago Bautista, J. M. Lafuente Salinas, M. Güell Farré, E. Girós Torres, J. Martín-Baranera, M. Miralles Basseda, R. | Rev Clin Esp (Barc) | 2022 |
Aged |
| Melatonin in ICU delirium: shining light on the hormone of darkness | Burry, L. Sonneville, R. Ely, E. W. | Intensive Care Med | 2022 | |
| The association between the inflammatory response following surgery and post-operative delirium in older oncological patients: a prospective cohort study | Brattinga, B. Plas, M. Spikman, J. M. Rutgers, A. de Haan, J. J. Absalom, A. R. van der Wal-Huisman, H. de Bock, G. H. van Leeuwen, B. L. | Age Ageing | 2022 |
Aged |
| Brain Network Dysfunction in Poststroke Delirium and Spatial Neglect: An fMRI Study | Boukrina, O. Kowalczyk, M. Koush, Y. Kong, Y. Barrett, A. M. | Stroke | 2022 |
Adult |
| Postoperative delirium prediction using machine learning models and preoperative electronic health record data | Bishara, A. Chiu, C. Whitlock, E. L. Douglas, V. C. Lee, S. Butte, A. J. Leung, J. M. Donovan, A. L. | BMC Anesthesiol | 2022 |
Aged |
| High-dose preoperative glucocorticoid for prevention of emergence and postoperative delirium in liver resection: A double-blinded randomized clinical trial substudy | Awada, H. N. Steinthorsdottir, K. J. Schultz, N. A. Hillingsø, J. G. Larsen, P. N. Jans, Ø Kehlet, H. Aasvang, E. K. | Acta Anaesthesiol Scand | 2022 |
emergence |
| Grip strength as a predictor of postoperative delirium in patients with colorectal cancers | Arita, A. Takahashi, H. Ogino, T. Miyoshi, N. Uemura, M. Akasaka, H. Sugimoto, K. Rakugi, H. Doki, Y. Eguchi, H. | Ann Gastroenterol Surg | 2022 |
colorectal cancer |
| Positive scores on the 4AT delirium assessment tool at hospital admission are linked to mortality, length of stay and home time: two-centre study of 82,770 emergency admissions | Anand, A. Cheng, M. Ibitoye, T. Maclullich, A. M. J. Vardy, Erlc | Age Ageing | 2022 |
4 ‘A’s Test (4AT) |
| Barriers to completing the 4AT for delirium and its clinical implementation in two hospitals: a mixed-methods study | Alhaidari, A. A. O. Matsis, K. P. | Eur Geriatr Med | 2022 |
Aged |
| The quality of palliative sedation in end-stage disease: audit from a department of oncology and haematology | Alessia, S. Matilde, S. F. Chrystel, I. Massimiliano, S. Daniele, D. Claudia, F. Raffaella, P. Flavia, C. Leonardo, F. Chiara, C. Leonardo, P. Massimo, D. Mario, L. Giuseppe, L. | Support Care Cancer | 2022 |
Conscious Sedation/methods |
| Delirium risk in geriatric hip hemi-arthroplasty (DRIGHA): Development and validation of a novel score using a national data | Ahmed, N. Kuo, Y. H. | Injury | 2022 |
Aged |
| Postoperative delirium and its relationship with biomarkers for dementia: a meta-analysis | Wang, S. Greene, R. Song, Y. Chan, C. Lindroth, H. Khan, S. Rios, G. Sanders, R. D. Khan, B. | Int Psychogeriatr | 2022 |
Alzheimer’s disease |
| The association between midazolam premedication and postoperative delirium - a retrospective cohort study | Zarour, S. Weiss, Y. Kiselevich, Y. Iacubovici, L. Karol, D. Shaylor, R. Davydov, T. Matot, I. Cohen, B. | J Clin Anesth | 2023 |
Anesthesia, Elderly, Midazolam, Postoperative delirium |
| Effects of perioperative intravenous glucocorticoids on perioperative neurocognitive disorders in adults after surgery: A PRISMA-compliant meta-analysis of randomized controlled trials | Wang, F. Hao, X. Zhu, Y. | Medicine (Baltimore) | 2023 |
Humans, Adult, Adolescent, *Glucocorticoids, Randomized Controlled Trials as Topic, Administration, Intravenous, *Hip Fractures, Neurocognitive Disorders |
| Association between emergency department modifiable risk factors and subsequent delirium among hospitalized older adults | Oliveira, J. E. Silva L. Stanich, J. A. Jeffery, M. M. Lindroth, H. L. Miller, D. M. Campbell, R. L. Rabinstein, A. A. Pignolo, R. J. Bellolio, F. | Am J Emerg Med | 2022 |
Acute brain failure |
| Practices in sedation, analgesia, mobilization, delirium, and sleep deprivation in adult intensive care units (SAMDS-ICU): an international survey before and during the COVID-19 pandemic | Luz, M. Brandão Barreto, B. de Castro, R. E. V. Salluh, J. Dal-Pizzol, F. Araujo, C. De Jong, A. Chanques, G. Myatra, S. N. Tobar, E. Gimenez-Esparza Vich, C. Carini, F. Ely, E. W. Stollings, J. L. Drumright, K. Kress, J. Povoa, P. Shehabi, Y. Mphandi, W | Ann Intensive Care | 2022 |
Analgesia |
| Mental capacity legislation and communication disability: A cross-sectional survey exploring the impact of the COVID-19 pandemic on the provision of specialist decision-making support by UK SLTs | Jayes, M. Borrett, S. Bose, A. | Int J Lang Commun Disord | 2022 |
Adult |
| Delirium and Associated Factors in a Cohort of Hospitalized Patients With Coronavirus Disease 2019 | García-Grimshaw, M. Chiquete, E. Jiménez-Ruiz, A. Vidal-Mayo, J. J. Grajeda-González, S. L. Vargas-Martínez, MlÁ Toapanta-Yanchapaxi, L. N. Valdés-Ferrer, S. I. Chávez-Martínez, O. A. Marché-Fernández, O. A. Jiménez-Ávila, A. I. Cantú-Brito, | J Acad Consult Liaison Psychiatry | 2022 |
Adult |
| Inpatient Diagnosis of Delirium and Encephalopathy: Coding Trends in 2011-2018 | Franks, J. A. Anderson, J. L. Bowman, E. Li, C. Y. Kennedy, R. E. Yun, H. | J Acad Consult Liaison Psychiatry | 2022 |
Dsm |
| Effectiveness of combined non-pharmacological interventions in the prevention of delirium in critically ill patients: A randomized clinical trial | Faustino, T. N. Suzart, N. A. Rabelo, Rnds Santos, J. L. Batista, G. S. Freitas, Y. S. Saback, D. A. Sales, Nmmd Brandao Barreto, B. Gusmao-Flores, D. | J Crit Care | 2022 |
Critical Care |
| Combined cerebral and somatic near-infrared spectroscopy oximetry monitoring during liver surgery: an observational and non-interventional study | Collin, Y. Hu, T. Denault, A. Fortier, A. Beaubien-Souligny, W. Lapointe, R. Vandenbroucke-Menu, F. | Korean J Anesthesiol | 2022 |
Hepatectomy |
| Characteristics and Outcome Determinants of Hospitalized Older Patients with Cognitive Dysfunction | Chao, Y. T. Kuo, F. H. Lee, Y. S. Huang, Y. H. Weng, S. C. Chou, Y. Y. Lin, C. S. Lin, S. Y. | Int J Environ Res Public Health | 2022 |
Activities of Daily Living |
| Delirium in hospitalized patients with COVID-19 pneumonia: a prospective, cross-sectional, cohort study | Callea, A. Conti, G. Fossati, B. Carassale, L. Zagaria, M. Caporotundo, S. Ziglioli, E. Brunetti, V. Della Marca, G. Rollo, E. | Intern Emerg Med | 2022 |
Covid-19 |
| Association of perioperative midazolam use and complications: a population-based analysis | Athanassoglou, V. Cozowicz, C. Zhong, H. Illescas, A. Poeran, J. Liu, J. Poultsides, L. Memtsoudis, S. G. | Reg Anesth Pain Med | 2022 |
analgesia |
| Best practices to prevent delirium in hospitalised patients | Yerra, S. Yarra, P. | Evid Based Nurs | 2022 |
*Delirium/prevention & control |
| Inhalational Versus Propofol-based Intravenous Maintenance of Anesthesia for Emergence Delirium in Adults: A Meta-analysis and Trial Sequential Analysis | Yang, Y. Feng, L. Ji, C. Lu, K. Chen, Y. Chen, B. | J Neurosurg Anesthesiol | 2022 | |
| Role of interleukin-18 in postoperative delirium: an exploratory analysis | Wu, J. G. Taylor, J. Parker, M. Kunkel, D. Rivera, C. Pearce, R. A. Lennertz, R. Sanders, R. D. | Br J Anaesth | 2022 |
delirium |
| Effect of general anesthesia with thoracic paravertebral block on postoperative delirium in elderly patients undergoing thoracoscopic lobectomy: a randomized-controlled trial | Wei, W. Zheng, X. Gu, Y. Fu, W. Tang, C. Yao, Y. | BMC Anesthesiol | 2022 |
*Postoperative delirium |
| Probable Delirium and Associated Patient Characteristics in Long-Term Care and Complex Continuing Care: A Population-Based Observational Study | Webber, C. Watt, C. L. Bush, S. H. Lawlor, P. G. Knoefel, F. Momoli, F. Thavorn, K. Casey, G. Tanuseputro, P. | J Am Med Dir Assoc | 2022 |
Cross-Sectional Studies |
| Postoperative delirium and its relationship with biomarkers for dementia: a meta-analysis | Wang, S. Greene, R. Song, Y. Chan, C. Lindroth, H. Khan, S. Rios, G. Sanders, R. D. Khan, B. | Int Psychogeriatr | 2022 |
Alzheimer’s disease |
| Melatonin and melatonergic agents for the prevention of postoperative delirium: A meta-analysis of randomized placebo-controlled trials | Wang, C. M. Zhou, L. Y. | Asian J Surg | 2022 |
Adult |
| Dexmedetomidine for prevention of postoperative delirium in older adults undergoing oesophagectomy with total intravenous anaesthesia | Valent, A. Carval, A. Cattan, P. Plaud, B. | Eur J Anaesthesiol | 2022 |
Aged |
| Transfusion-Associated Delirium in Children: No Difference Between Short Storage Versus Standard Issue RBCs | Traube, C. Tucci, M. Nellis, M. E. Avery, K. L. McQuillen, P. S. Fitzgerald, J. C. Muszynski, J. A. Cholette, J. M. Schwarz, A. J. Stalets, E. L. Quaid, M. A. Hanson, S. J. Lacroix, J. Reeder, R. W. Spinella, P. C. | Crit Care Med | 2022 | |
| Pediatric Delirium: We Have Come a Long Way, and We Have Only Just Begun | Traube, C. | Crit Care Med | 2022 | |
| Beware the Aftermath: Delirium and Post-Intensive Care Syndrome in Critically Ill Children | Traube, C. | Pediatr Crit Care Med | 2022 | |
| Amyloid deposition on positron emission tomography correlates with severity of perioperative delirium: a case-control pilot study | Torres-Velázquez, M. Parker, M. Bo, A. White, M. Tanabe, S. Pearce, R. A. Lennertz, R. Cho, S. Y. Bendlin, B. Johnson, S. C. Prabhakaran, V. McMillan, A. B. Sanders, R. D. | Br J Anaesth | 2022 |
amyloid |
| VE-CAM-S: Visual EEG-Based Grading of Delirium Severity and Associations With Clinical Outcomes | Tesh, R. A. Sun, H. Jing, J. Westmeijer, M. Neelagiri, A. Rajan, S. Krishnamurthy, P. V. Sikka, P. Quadri, S. A. Leone, M. J. Paixao, L. Panneerselvam, E. Eckhardt, C. Struck, A. F. Kaplan, P. W. Akeju, O. Jones, D. Kimchi, E. Y. Westover, M. B. | Crit Care Explor | 2022 |
Eeg |
| KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients | Terrelonge, M. LaHue, S. C. Tang, C. Movsesyan, I. Pullinger, C. R. Dubal, D. B. Leung, J. Douglas, V. C. | Sci Rep | 2022 | |
| Pilot Study of Lemborexant for Insomnia in Cancer Patients with Delirium | Terada, T. Hirayama, T. Sadahiro, R. Wada, S. Nakahara, R. Matsuoka, H. | J Palliat Med | 2022 |
cancer patients |
| Managing agitation secondary to hyperactive delirium in deteriorating patients | Teece, A. | Nurs Stand | 2022 |
*Delirium/etiology |
| Incidence of Delirium With Different Oral Opioids in Previously Opioid-Naive Patients | Sugiyama, Y. Tanaka, R. Sato, T. Sato, T. Saitoh, A. Yamada, D. Shino, M. | Am J Hosp Palliat Care | 2022 |
concomitant drugs |
| Adult behavior toward the child before surgery and pediatric emergence delirium | Sobol, M. Sobol, M. K. Kowal, M. | Paediatr Anaesth | 2022 |
Adult |
| Risk Factors for Delirium and Association of Antipsychotic Use with Delirium Progression in Critically Ill Trauma Patients | Shoulders, B. R. Elsabagh, S. Tam, D. J. Frantz, A. M. Alexander, K. M. Voils, S. A. | Am Surg | 2022 |
antipsychotic |
| Incidence and Risk Factors of Ventilator-Associated Pneumonia among Patients with Delirium in the Intensive Care Unit: A Prospective Observational Study | Shamsizadeh, M. Fathi Jouzdani, A. Rahimi-Bashar, F. | Crit Care Res Pract | 2022 | |
| Delirium in older adults, if you think it's the urine, think again | Schonnop, R. Woods, R. Ellis, B. | Cjem | 2022 | |
| The detection of delirium in admitted oncology patients: a scoping review | Sands, M. B. Wee, I. Agar, M. Vardy, J. L. | Eur Geriatr Med | 2022 |
Cancer |
| Delirium in the Context of Zonisamide-Induced Toxic Epidermal Necrolysis | Reinfeld, S. Tejeda, C. I. Koola, M. M. | Prim Care Companion CNS Disord | 2022 | |
| Prevalence of Delirium in End-of-life Palliative Care Patients: An Observational Study | Recchia, A. Rizzi, B. Favero, A. Nobili, A. Pasina, L. | Med Princ Pract | 2022 | |
| Hospitalizations of older people in an emergency department related to potential medication-induced hyperactive delirium: a cross-sectional study | Raso, J. Santos, L. M. C. Reis, D. A. Frangiotti, M. A. C. Zanetti, A. C. B. Capucho, H. C. Herdeiro, M. T. Roque, F. Pereira, L. R. L. Varallo, F. R. | Int J Clin Pharm | 2022 |
Aged |
| Clinical Significance of Delirium With Catatonic Signs in Patients With Neurological Disorders | Ramirez-Bermudez, J. Medina-Gutierrez, A. Gomez-Cianca, H. Arias, P. Pérez-Gonzalez, A. Lebrija-Reyes, P. A. Espinola-Nadurille, M. Aguilar-Venegas, L. C. Ojeda-López, C. Restrepo-Martínez, M. Bayliss, L. Juárez-Jaramillo, C. A. Peñaloza, G. Rivas-Al | J Neuropsychiatry Clin Neurosci | 2022 |
Catatonia |
| Patient perspectives on delirium and cognitive dysfunction after surgery: a cross-sectional survey | Ragheb, J. Khatibi, N. McKinney, A. Brooks, J. Hill-Carruthers, M. Vlisides, P. E. | Br J Anaesth | 2022 |
cognitive dysfunction |
| Association between delirium and cognitive impairment: there is a link? | Pistacchi, M. Gioulis, M. Marsala, S. Z. | Curr Alzheimer Res | 2022 |
Cognitive Impairment |
| Utility of white matter disease and atrophy on routinely acquired brain imaging for prediction of long-term delirium risk: population-based cohort study | Pendlebury, S. T. Thomson, R. J. Welch, S. J. V. Kuker, W. Rothwell, P. M. | Age Ageing | 2022 |
Atrophy/pathology |
| Massachusetts Intensive Care Unit Nurses From Multiple Hospitals Develop a Collaborative to Improve Delirium Assessment Accuracy | O'Donoghue, S. C. Meyers, K. Manning, C. R. Pellegrino, L. S. Ryan, C. P. Crowell, A. M. Nolan, L. M. Gallagher, G. E. | Dimens Crit Care Nurs | 2022 |
Critical Care |
| Incidence and factors associated with postoperative delirium in patients undergoing transurethral resection of bladder tumor | Nakatani, S. Ida, M. Wang, X. Naito, Y. Kawaguchi, M. | JA Clin Rep | 2022 |
Age |
| Association of Nutritional Status with New-Onset Delirium in Elderly, Acute Care, Orthopaedic Trauma Patients: A Single-Center Observational Study | Maher, S. S. Franco-Garcia, E. Zhou, C. Heng, M. van Pelt, M. Akeju, O. Quraishi, S. A. | J Orthop Trauma | 2022 |
Aged |
| Efficacy of EWINDOW for prevention of delirium at intensive care units: A protocol for systematic review and meta-analysis | Liu, J. Wang, J. | Medicine (Baltimore | 2022 |
delirium, EWINDOW, intensive care units |
| Delirium and subsyndromal delirium are associated with the long-term risk of death after ischaemic stroke | Klimiec-Moskal, E. Slowik, A. Dziedzic, T. | Aging Clin Exp Res | 2022 |
Delirium |
| An innovative post-hospital model of care (DDEFY Delirium): A pilot randomized trial | Khan, A. Uribe-Cano, D. Klumph, M. Simpson, M. Macias Tejada, J. Galambos, C. Hubatch, S. Malone, M. L. | J Am Geriatr Soc | 2022 | |
| Impact of postanesthesia care unit delirium on self-reported cognitive function and perceived health status: a prospective observational cohort study | Kainz, E. Stuff, K. Kahl, U. Wiessner, C. Yu, Y. von Breunig, F. Nitzschke, R. Haese, A. Graefen, M. Fischer, M. | Qual Life Res | 2022 |
Anesthesia recovery period |
| Can multifaceted educational intervention improve clinical practice and patient outcomes regarding delirium in nursing homes? | Jeong, E. Chang, S. O | Jpn J Nurs Sci | 2022 |
Aged |
| Does Preoperative Cognitive Optimization Improve Postoperative Outcomes in the Elderly? | Ishizawa, Y. | J Clin Med | 2022 |
advanced age |
| Postoperative Delirium in Lung Cancer Anatomical Resection-Analysis of Risk Factors and Prognosis | Ishibashi, H. Wakejima, R. Asakawa, A. Sugita, Y. Ishikawa, Y. Hanafusa, M. Baba, S. Nakashima, Y. Seto, K. Okubo, K. | World J Surg | 2022 | |
| Preoperative Risk Factors and Early Outcomes of Delirium in Valvular Open-Heart Surgery | Hulde, N. Zittermann, A. Tigges-Limmer, K. Koster, A. Weinrautner, N. Gummert, J. von Dossow, V. | Thorac Cardiovasc Surg | 2022 | |
| Plasma 5-HIAA activity indicative of serotonergic disturbances in cognitively impaired, elderly patients experiencing postoperative delirium | Heylen, A. Vermeiren, Y. De Rooij, S. E. Scholtens, R. M. Van Munster, B. C. Van Dam, D. De Deyn, P. P. | Int J Geriatr Psychiatry | 2022 |
Aged |
| Depression, Delirium and Post-Intensive Care Syndrome | Garcez-Leme, L. E. Avelino-Silva, T. J. | Int Psychogeriatr | 2022 | |
| Usefulness of Preoperative Controlling Nutritional Status in Predicting Prolonged Hospitalization and Incidence of Postoperative Delirium for Elderly Hepatectomy with Hepatocellular Carcinoma | Fujio, A. Usuda, M. Hara, Y. Kakizaki, Y. Okada, K. Miyata, G. Unno, M. Kamei, T. | Tohoku J Exp Med | 2022 |
Aged |
| Inpatient Diagnosis of Delirium and Encephalopathy: Coding Trends 2011-2018 | Franks, J. A. Anderson, J. L. Bowman, E. Li, C. Y. Kennedy, R. E. Yun, H. | J Acad Consult Liaison Psychiatry | 2022 |
Dsm |
| Barriers and facilitators to nursing delirium screening in older emergency patients: a qualitative study using the theoretical domains framework | Eagles, D. Cheung, W. J. Avlijas, T. Yadav, K. Ohle, R. Taljaard, M. Molnar, F. Stiell, I. G. | Age Ageing | 2022 |
Aged |
| The evidence for introducing case-finding for delirium and dementia in older medical inpatients in a New Zealand hospital | Cullum, S. Kubba, Y. Varghese, C. Coomarasamy, C. Hopkins, J. | Australas Psychiatry | 2022 |
case-finding |
| Pediatric delirium in times of COVID-19 | Castro, R. E. V. Rodríguez-Rubio, M. Magalhães-Barbosa, M. C. Prata-Barbosa, A. | Rev Bras Ter Intensiva | 2022 |
*covid-19 |
| Accuracy of delirium risk factors in adult intensive care unit patients | Carvalho, L. A. C. Correia, M. D. L. Ferreira, R. C. Botelho, M. L. Ribeiro, E. Duran, E. C. M. | Rev Esc Enferm USP | 2022 |
Adult |
| The management of delirium in the older adult in advanced nursing practice | Carey, E. Furlong, E. Smith, R. | Br J Nurs | 2022 |
*Advanced Practice Nursing |
| Postoperative Delirium: The Search for Effective Interventions | Campbell, D. Short, T. G. Chan, M. T. V. | J Neurosurg Anesthesiol | 2022 | |
| Confusion and Representative Restraint: An Exercise in Clinical Reasoning | Bushunow, V. Klein, A. Follansbee, W. Bonifacino, E. | J Gen Intern Med | 2022 |
*Clinical Reasoning |
| Psychoactive medication therapy and delirium screening in skilled nursing facilities | Briesacher, B. A. Olivieri-Mui, B. L. Koethe, B. Saczynski, J. S. Fick, D. M. Devlin, J. W. Marcantonio, E. R. | J Am Geriatr Soc | 2022 |
delirium |
| Comparison of delirium detection tools in acute care : A rapid review | Brefka, S. Eschweiler, G. W. Dallmeier, D. Denkinger, M. Leinert, C. | Z Gerontol Geriatr | 2022 |
4As test |
| Implications of the COVID-19 pandemic: Virtual nursing education for delirium care | Bourgault, A. Mayerson, E. Nai, M. Orsini-Garry, A. Alexander, I. M. | J Prof Nurs | 2022 |
*covid-19 |
| Postoperative delirium prediction using machine learning models and preoperative electronic health record data | Bishara, A. Chiu, C. Whitlock, E. L. Douglas, V. C. Lee, S. Butte, A. J. Leung, J. M. Donovan, A. L. | BMC Anesthesiol | 2022 |
*Delirium prevention |
| Association between nonpharmacological strategies and delirium in intensive care unit | Bersaneti, M. D. R. Whitaker, I. Y. | Nurs Crit Care | 2022 |
caregivers |
| Differential Effects of Gamma-Aminobutyric Acidergic Sedatives on Risk of Post-Extubation Delirium in the ICU: A Retrospective Cohort Study From a New England Health Care Network | Azimaraghi, O. Wongtangman, K. Wachtendorf, L. J. Santer, P. Rumyantsev, S. Ahn, C. Kiyatkin, M. E. Teja, B. Sarge, T. Subramaniam, B. Eikermann, M. | Crit Care Med | 2022 |
Differential Effects Gamma-Aminobutyric Acidergic Sedatives Risk Post-Extubation Delirium ICU Retrospective Cohort Study |
| Risk factors for postoperative delirium after cardiac surgical procedures with cardioplegic arrest | Andrási, T. B. Talipov, I. Dinges, G. Arndt, C. Rastan, A. J. | Eur J Cardiothorac Surg | 2022 |
Cabg |
| Delirium screening tools in the post-anaesthetic care unit: a systematic review and meta-analysis | Aldwikat, R. K. Manias, E. Tomlinson, E. Amin, M. Nicholson, P. | Aging Clin Exp Res | 2022 |
Delirium |
| Effect of earplug/eye mask on sleep and delirium in intensive care patients | Akpinar, R. B. Aksoy, M. Kant, E. | Nurs Crit Care | 2022 |
delirium |
| Inclusion of interleukin-6 improved performance of postoperative delirium prediction for patients undergoing coronary artery bypass graft (POD-CABG): A derivation and validation study | Zhang, S. Ji, M. H. Ding, S. Wu, Y. Feng, X. W. Tao, X. J. Liu, W. W. Ma, R. Y. Wu, F. Q. Chen, Y. L. | J Cardiol | 2021 |
Coronary artery bypass graft surgery |
| DNA methylation in the TNF-alpha gene decreases along with aging among delirium inpatients | Yamanashi, T. Saito, T. Yu, T. Alario, A. Comp, K. Crutchley, K. J. Sullivan, E. J. Anderson, Z. M. Marra, P. S. Chang, G. Wahba, N. E. Jellison, S. S. Meyer, A. A. Mathur, S. Pandharipande, P. Yoshino, A. Kaneko, K. Lee, S. Toda, H. Iwata, M. Shinozaki, | Neurobiol Aging | 2021 |
Aged |