What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Unveiling the Immune Landscape of Delirium through Single-Cell RNA Sequencing and Machine Learning: Towards Precision Diagnosis and Therapy
- Authors
- Shi, Y. Xu, P.
- Year
- 2025
- Journal
- Psychogeriatrics
- Abstract
BACKGROUND: Postoperative delirium (POD) poses significant clinical challenges regarding its diagnosis and treatment. Identifying biomarkers that can predict and diagnose POD is crucial for improving patient outcomes. METHODS: To explore potential biomarkers for POD, we conducted bulk RNA sequencing (bulk-seq) on peripheral blood samples from POD patients and healthy controls. The expression levels of genes downstream of the phosphatidylinositol 3-kinase/protein kinase B (PI3K-Akt) signalling pathway were analysed. We then validated the expression of these genes using quantitative real-time polymerase chain reaction (RT-qPCR) in an independent cohort of 30 healthy controls and 30 POD patients. Receiver operating characteristic (ROC) analysis and six machine learning models were used to evaluate the predictive and diagnostic value of these genes. Additionally, single-cell RNA sequencing (scRNA-seq) was performed to validate gene expression in specific subsets of peripheral blood mononuclear cells (PBMCs), including T-cells, B-cells, natural killer (NK) cells, dendritic cells (DCs), and monocytes. RESULTS: Bulk-seq revealed increased expression of genes downstream of the PI3K-Akt signalling pathway, specifically CHRM2, IL6, NOS3, NGF, and IL6R, in the peripheral blood of POD patients compared to healthy controls. Conversely, the expression of IGF1 was significantly decreased. RT-qPCR validation confirmed these findings. ROC analysis and machine learning models indicated that these genes are useful for predicting and diagnosing POD. scRNA-seq further validated the expression of these genes in specific PBMC subsets, including T-cells, B-cells, NK cells, DCs, and monocytes, with results consistent with the bulk-seq and RT-qPCR data. CONCLUSIONS: The abnormal activation of the PI3K-Akt signalling pathway in T-cells, B-cells, NK cells, DCs, and monocytes may serve as potential biomarkers for predicting and diagnosing POD. These findings could inform the development of novel therapeutic strategies for managing POD.
- PMID
PMID: 39814058
- Keywords
Humans *Machine Learning *Sequence Analysis, RNA/methods Male *Delirium/diagnosis/genetics Female Aged Biomarkers/blood Leukocytes, Mononuclear/metabolism/immunology Middle Aged Signal Transduction/genetics Single-Cell Analysis/methods Proto-Oncogene Proteins c-akt/genetics Postoperative Complications/diagnosis Case-Control Studies machine learning peripheral blood mononuclear cells postoperative delirium single‐cell RNA sequencing
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Survey on Current Practice of Canadian Physicians Regarding the Investigation in Older Patients with Delirium | Laguë, A. Boucher, V. Joo, P. Yadav, K. Morasse, C. Émond, M. | Can Geriatr J | 2022 |
delirium |
| Clinical phenotypes of delirium in patients admitted to the cardiac intensive care unit | Ko, R. E. Kim, S. Lee, J. Park, S. Bae, D. Choi, K. H. Park, T. K. Chung, C. R. Yang, J. H. | PLoS One | 2022 |
*Delirium/epidemiology/etiology |
| Delirium, dementia, and depression (3D) assessment of older patients in the emergency department: 5-year survival analysis | Kılıçaslan, İ Thet, M. S. Karahacıoğlu, B. Sevim, M. Ülger, Z. Aslaner, M. A. Kılıçaslan, B. | Turk J Med Sci | 2022 |
Aged |
| Charles Bonnet Syndrome With Superimposed Delirium | Karson, C. Kang, C. Albrecht, B. Levin, G. | Cureus | 2022 |
antipsychotic |
| Prevalence and Long-Term Prognosis of Post-Intensive Care Syndrome after Sepsis: A Single-Center Prospective Observational Study | Inoue, S. Nakanishi, N. Sugiyama, J. Moriyama, N. Miyazaki, Y. Sugimoto, T. Fujinami, Y. Ono, Y. Kotani, J. | J Clin Med | 2022 |
Barthel Index |
| Mental health-related quality of life is related to delirium in intensive care patients | Hofhuis, J. G. M. Schermer, T. Spronk, P. E. | Intensive Care Med | 2022 |
Critical Care |
| Noise pareidolia test for predicting delirium in hospitalized older patients with cognitive decline | Hashimoto, Y. Kano, O. Ebihara, S. | Geriatr Gerontol Int | 2022 |
cognitive decline |
| Postoperative Delirium Severity and Recovery Correlate With Electroencephalogram Spectral Features | Guay, C. S. Kafashan, M. Huels, E. R. Jiang, Y. Beyoglu, B. Spencer, J. W. Geczi, K. Apakama, G. Ju, Y. S. Wildes, T. S. Avidan, M. S. Palanca, B. J. A. | Anesth Analg | 2022 | |
| Prevention and treatment of delirium in intensive care: Hermeneutics of experiences of the nursing team | Gómez Tovar, L. O. Henao-Castaño Á, M. Troche-Gutiérrez, I. Y. | Enferm Intensiva (Engl Ed) | 2022 |
*Critical Care |
| How do predisposing factors differ between delirium motor subtypes? A systematic review and meta-analysis | Ghezzi, E. S. Greaves, D. Boord, M. S. Davis, D. Knayfati, S. Astley, J. M. Sharman, R. L. S. Goodwin, S. I. Keage, H. A. D. | Age Ageing | 2022 |
Aged |
| Applying the geriatric 5Ms in critical care: the ICU-5Ms | Geen, O. Perrella, A. Rochwerg, B. Wang, X. M. | Can J Anaesth | 2022 |
Aged |
| Delirium in Persons With Dementia: Integrating the 4Ms of Age-Friendly Care as a Set Into the Care of Older People | Fick, D. M. Shrestha, P. | J Gerontol Nurs | 2022 |
Aged |
| The effect of melatonin on prevention of postoperative delirium after lower limb fracture surgery in elderly patients: a randomized double blind clinical trial | Fazel, M. R. Mofidian, S. Mahdian, M. Akbari, H. Razavizadeh, M. R. | Int J Burns Trauma | 2022 |
Melatonin |
| Risk factors for delirium after surgery for craniocerebral injury in the neurosurgical intensive care unit | Chen, R. Y. Zhong, C. H. Chen, W. Lin, M. Feng, C. F. Chen, C. N | World J Clin Cases | 2022 |
Brain injury |
| Risk factors and a nomogram model for postoperative delirium in elderly gastric cancer patients after laparoscopic gastrectomy | Chen, J. Ji, X. Xing, H. | World J Surg Oncol | 2022 |
Aged |
| Self-efficacy of caring for patients in the intensive care unit with delirium: Development and validation of a scale for intensive care unit nurses | Chang, Y. L. Hsieh, M. J. Chang, Y. C. Yeh, S. L. Chen, S. W. Tsai, Y. F. | Aust Crit Care | 2022 |
Delirium |
| A nurse-led intervention to reduce the incidence and duration of delirium among adults admitted to intensive care: A stepped-wedge cluster randomised trial | Brennan, K. Sanchez, D. Hedges, S. Lynch, J. Hou, Y. C. Al Sayfe, M. Shunker, S. A. Bogdanoski, T. Hunt, L. Alexandrou, E. He, S. Mai, H. Rolls, K. Frost, S. A. | Aust Crit Care | 2022 |
Delirium prevention |
| Association of cholinesterase activities and POD in older adult abdominal surgical patients | Bosancic, Z. Spies, C. D. Müller, A. Winterer, G. Piper, S. K. Heinrich, M | BMC Anesthesiol | 2022 |
Aged |
| Management of delirium in older adults: challenges and opportunities | Bingham, K. S. Flint, A. J. | 2022 |
Aged |
|
| Emergence delirium after intracranial neurosurgery- a prospective cohort study | Bharadwaj, S. Konar, S. Akash, V. S. Gopalakrishna, K. N. Chakrabarti, D. Kamath, S. | J Clin Neurosci | 2022 |
Adolescent |
| A novel approach for the detection of cognitive impairment and delirium risk in older patients undergoing spine surgery | Barreto Chang, O. L. Whitlock, E. L. Arias, A. D. Tsoy, E. Allen, I. E. Hellman, J. Bickler, P. E. Miller, B. Possin, K. L. | J Am Geriatr Soc | 2022 |
anesthesia and surgery |
| Temporal Variability in Inflammatory Gene Methylation and Delirium in Critically Ill Patients | Alexander, S. A. Conley, Y. P. Girard, T. D. McVerry, B. J. Ren, D. | Am J Crit Care | 2022 |
Adolescent |
| Machine Learning-Based Prediction Models for Delirium: A Systematic Review and Meta-Analysis | Xie, Q. Wang, X. Pei, J. Wu, Y. Guo, Q. Su, Y. Yan, H. Nan, R. Chen, H. Dou, X. | J Am Med Dir Assoc | 2022 |
Machine learning algorithm |
| Baseline Anxiety and Depression and Risk for ICU Delirium: A Prospective Cohort Study | Wu, T. T. Kooken, R. Zegers, M. Ko, S. Bienvenu, O. J. Devlin, J. W. van den Boogaard, M. | Crit Care Explor | 2022 |
anxiety |
| Preoperative Cognitive Impairment and Postoperative Delirium in Elderly Surgical Patients - a Retrospective Large Cohort Study | Weiss, Y. Zac, L. Refaeli, E. Ben-Yishai, S. Zegerman, A. Cohen, B. Matot, I. | Ann Surg | 2022 | |
| Goal-directed therapy based on rScO(2) monitoring in elderly patients with one-lung ventilation: a randomized trial on perioperative inflammation and postoperative delirium | Wang, J. Y. Li, M. Wang, P. Fang, P. | Trials | 2022 |
Aged |
| Impact of propofol versus sevoflurane on the incidence of postoperative delirium in elderly patients after spine surgery: study protocol of a randomized controlled trial | Wang, J. H. Lv, M. Zhang, H. X. Gao, Y. Chen, T. T. Wan, T. T. Wang, Y. L. | Trials | 2022 |
Aged |
| Impact of propofol versus sevoflurane on the incidence of postoperative delirium in elderly patients after spine surgery: study protocol of a randomized controlled trial | Wang, J. H. Lv, M. Zhang, H. X. Gao, Y. Chen, T. T. Wan, T. T. Wang, Y. L. | Trials | 2022 |
Aged |
| Potential Value of Serum Uric Acid in the Identification of Postoperative Delirium in Geriatric Patients Undergoing Knee Replacement | Wang, F. Tang, X. Wang, J. Liu, S. Wu, X. Dong, R. Lin, X. Wang, B. Bi, Y. | Front Aging Neurosci | 2022 |
Alzheimer-related biomarkers |
| Patient Outcomes After Delirium Screening and Incident Alzheimer's Disease or Related Dementias in Skilled Nursing Facilities | Vo, Q. T. Koethe, B. Holmes, S. Simoni-Wastila, L. Briesacher, B. A. | J Gen Intern Med | 2022 |
Alzheimer’s disease |
| Delirium in head trauma: looking for a culprit | Villani, E. R. Franza, L. Cianci, R. | Rev Recent Clin Trials | 2022 |
Delirium |
| Timing, Threshold, and Duration of Intraoperative Hypotension in Cardiac Surgery: Their Associations With Postoperative Delirium | Ushio, M. Egi, M. Fujimoto, D. Obata, N. Mizobuchi, S. | J Cardiothorac Vasc Anesth | 2022 |
Cardiac valvular surgery |
| Detecting delirium in nursing home residents using the Informant Assessment of Geriatric Delirium (I-AGeD): a validation pilot study | Urfer Dettwiler, P. Zúñiga, F. Bachnick, S. Gehri, B. de Jonghe, J. F. M. Hasemann, W. | Eur Geriatr Med | 2022 |
Aged |
| Association of preoperative frailty and postoperative delirium in older cancer patients undergoing elective abdominal surgery: a prospective observational study in Taiwan | Tsai, C. Y. Liu, K. H. Lai, C. C. Hsu, J. T. Hsueh, S. W. Hung, C. Y. Yeh, K. Y. Hung, Y. S. Lin, Y. C. Chou, W. C. | Biomed J | 2022 |
cancer |
| Delirium and Cortical Complexity: Divergent Changes in Alpha and Theta Bands | Tanabe, S. Parker, M. Lennertz, R. Pearce, R. A. Banks, M. I. Sanders, R. D. | J Gerontol A Biol Sci Med Sci | 2022 | |
| Escaping delirium: Designing an escape room active learning experience for geriatric resource nurses | Stoller, A. Iannuzzo, S. Davis, K. | Geriatr Nurs | 2022 |
Creative problem solving |
| Perivascular spaces visible on magnetic resonance imaging predict subsequent delirium in older patients | Song, Q. Zhao, Y. Lin, T. Yue, J. | Front Aging Neurosci | 2022 |
cerebral small vessel disease |
| Postoperative delirium does not affect cardiopulmonary exercise testing in aged patients undergoing cardiac valve surgery | Shimomoto, Y. Mukaiyama, K. Hori, T. Inaki, Y. Masai, T. Hayashi, Y. | JA Clin Rep | 2022 |
Cardiac rehabilitation |
| Silent cerebral ischemia detected by magnetic resonance imaging can predict postoperative delirium after total arch replacement for aneurysm | Shibagaki, K. Shirasaka, T. Sawada, J. Saijo, Y. Kunioka, S. Kikuchi, Y. Kamiya, H. | JTCVS Open | 2022 |
AAA, aortic arch aneurysm |
| Impact of delirium on the outcome of stroke: a prospective, observational, cohort study | Rollo, E. Brunetti, V. Scala, I. Callea, A. Marotta, J. Vollono, C. Frisullo, G. Broccolini, A. Calabresi, P. Della Marca, G. | J Neurol | 2022 |
Delirium |
| Association between non-English language and use of physical and chemical restraints among medical inpatients with delirium | Reppas-Rindlisbacher, C. Shin, S. Purohit, U. Verma, A. Razak, F. Rochon, P. Sheehan, K. Rawal, S. | J Am Geriatr Soc | 2022 | |
| Sedation, analgesia, and delirium management in Portugal: a survey and point prevalence study | Paulino, M. C. Pereira, I. J. Costa, V. Neves, A. Santos, A. Teixeira, C. M. Coimbra, I. Fernandes, P. Bernardo, R. Póvoa, P. Granja, C. | Rev Bras Ter Intensiva | 2022 |
*Analgesia |
| Acute kidney injury-associated delirium: a review of clinical and pathophysiological mechanisms | Pang, H. Kumar, S. Ely, E. W. Gezalian, M. M. Lahiri, S. | Crit Care | 2022 |
*Acute Kidney Injury |
| Delirium Development After Lung Transplantation: An Intraoperative Assessment | Ozay, H. Y. Bindal, M. Turkkan, S. Beyoglu, M. A. Yekeler, E. Turan, S. | Transplant Proc | 2022 | |
| Delirium severity does not differ between medical and surgical intensive care units after adjusting for medication use | Ortiz, D. Lindroth, H. L. Braly, T. Perkins, A. J. Mohanty, S. Meagher, A. D. Khan, S. H. Boustani, M. A. Khan, B. A. | Sci Rep | 2022 |
Activities of Daily Living |
| Risk factors for postoperative delirium on oxygen delivery-guided perfusion | Mukaida, H. Matsushita, S. Minami, Y. Sato, G. Usuba, M. Kondo, R. Asai, T. Amano, A. | J Cardiothorac Surg | 2022 |
Cardiopulmonary Bypass/adverse effects/methods |
| Identifying Medicare Beneficiaries With Delirium | Moura, Lmvr Zafar, S. Benson, N. M. Festa, N. Price, M. Donahue, M. A. Normand, S. L. Newhouse, J. P. Blacker, D. Hsu, J. | Med Care | 2022 | |
| The development of a web-based app employing machine learning for delirium prevention in long-term care facilities in South Korea | Moon, K. J. Son, C. S. Lee, J. H. Park, M. | BMC Med Inform Decis Mak | 2022 |
*Delirium/diagnosis/prevention & control |
| Impact of Family Presence on Delirium in Critically Ill Patients: A Retrospective Cohort Study | Mohsen, S. Moss, S. J. Lucini, F. Krewulak, K. D. Stelfox, H. T. Niven, D. J. Sauro, K. M. Fiest, K. M. | Crit Care Med | 2022 | |
| Serum levels of apolipoprotein A-I and E are associated with postoperative delirium: A post hoc analysis | Mietani, K. Hasegawa-Moriyama, M. Inoue, R. Ogata, T. Shimojo, N. Kurano, M. Yatomi, Y. Uchida, K. Sumitani, M. | Medicine (Baltimore) | 2022 |
Aged |
| Staff training and the use of rapid, accurate and user-friendly tools for delirium screening could improve the diagnosis of delirium in the elderly referred to the emergency department | Mazzola, P. Spedale, V. | Evid Based Nurs | 2022 |
evidence-based nursing |
| Current practice of pharmacological treatment for hyperactive delirium in terminally ill cancer patients: results of a nationwide survey of Japanese palliative care physicians and liaison psychiatrists | Matsuda, Y. Morita, T. Oya, K. Tagami, K. Naito, A. S. Kashiwagi, H. Otani, H. | Jpn J Clin Oncol | 2022 |
*Antipsychotic Agents/therapeutic use |
| Higher serum PGE2 is a predicative biomarker for postoperative delirium following elective orthopedic surgery in elderly patients | Mao, M. Wang, L. Y. Zhu, L. Y. Wang, F. Ding, Y. Tong, J. H. Sun, J. Sun, Q. Ji, M. H. | BMC Geriatr | 2022 |
Aged |
| Effect of acute pain on the association between preoperative cognitive impairment and postoperative delirium: a secondary analysis of three trials | Ma, J. H. Liu, Y. F. Hong, H. Li, C. J. Cui, F. Mu, D. L. Wang, D. X. | Br J Anaesth | 2022 |
cognitive dysfunction |
| A systematic review of modified electroconvulsive therapy (ECT) to treat delirium | Lupke, K. Warren, N. Teodorczuk, A. Steele, S. Kolur, U. Wand, A. Robinson, G. Parker, S. | Acta Psychiatr Scand | 2022 |
acute confusion |
| Incidence and interaction factors of delirium as an independent risk of mortality in elderly patients in the intensive units: a retrospective analysis from MIMIC-IV database | Liu, H. Zhao, Q. Liu, X. Hu, X. Wang, L. Zhou, F. | Aging Clin Exp Res | 2022 |
Delirium |
| The effect of neostigmine on postoperative delirium after colon carcinoma surgery: a randomized, double-blind, controlled trial | Liu, F. Lin, X. Lin, Y. Deng, X. Guo, Y. Wang, B. Dong, R. Bi, Y. | BMC Anesthesiol | 2022 |
Adult |
| Outcomes of postoperative delirium in patients undergoing cardiac surgery: A systematic review and meta-analysis | Lin, L. Zhang, X. Xu, S. Peng, Y. Li, S. Huang, X. Chen, L. Lin, Y. | Front Cardiovasc Med | 2022 |
cardiac surgery |
| Non-pharmacological delirium prevention practices among critical care nurses: a qualitative study | Liang, S. Chau, J. P. C. Lo, S. H. S. Zhao, J. Liu, W. | BMC Nurs | 2022 |
Delirium |
| Effect of regional anesthesia on the postoperative delirium: A systematic review and meta-analysis of randomized controlled trials | Li, T. Dong, T. Cui, Y. Meng, X. Dai, Z. | Front Surg | 2022 |
delirium |
| Assessing Delirium at Hospital Discharge | Lepkowsky, C. M. Janklow, H. M. | Am J Geriatr Psychiatry | 2022 |
Delirium |
| The Effects of Pain, Agitation, Delirium, Immobility, and Sleep Disruption Education on Novice Nurses in Adult Intensive Care Units | Lee, S. Y. Liu, C. Y. Wu, T. Y. | Healthcare (Basel) | 2022 |
Padis |
| Treatment of Positive Urine Cultures at End-of-Life and the Effect on Terminal Delirium Management | Latuga, N. M. Grant, P. C. Levy, K. Luczkiewicz, D. L. | Am J Hosp Palliat Care | 2022 |
Anti-Bacterial Agents/therapeutic use |
| Risk factors and effect of postoperative delirium on adverse surgical outcomes in older adults after elective abdominal cancer surgery in Taiwan | Lai, C. C. Liu, K. H. Tsai, C. Y. Hsu, J. T. Hsueh, S. W. Hung, C. Y. Chou, W. C. | Asian J Surg | 2022 |
Cancer surgery |
| A Quality Improvement Study on Delirium Awareness Day: In Pursuit of Missed Delirium Diagnoses | Koca, M. Öztürk, Y. Boğa, İ Bürkük, S. Eşme, M. Akyürek, Y. Şimşek, S. Aydın, D. D. Çiçek, F. Karabulut, E. Halil, M. Cankurtaran, M. Tanrıöver, M. D. Doğu, B. B. | J Gerontol Nurs | 2022 |
Aged |
| Serum C-reactive protein adds predictive information for post-stroke delirium: The PROPOLIS study | Klimiec-Moskal, E. Slowik, A. Dziedzic, T. | Acta Psychiatr Scand | 2022 |
Crp |
| External validation and comparison of two delirium prediction models in patients admitted to the cardiac intensive care unit | Kim, S. E. Ko, R. E. Na, S. J. Chung, C. R. Choi, K. H. Kim, D. Park, T. K. Lee, J. M. Song, Y. B. Choi, J. O. Hahn, J. Y. Choi, S. H. Gwon, H. C. Yang, J. H. | Front Cardiovasc Med | 2022 |
Early PREdiction of DELIRium |
| Delirium and Cortical Complexity | Kim, H. Lee, U. C. Vlisides, P. E. | Delirium and Cortical Complexity | 2022 | |
| Can Variables From the Electronic Health Record Identify Delirium at Bedside? | Khan, A. Heslin, K. Simpson, M. Malone, M. L. | J Patient Cent Res Rev | 2022 |
delirium |
| Thoracic Paravertebral Block Ameliorates Postoperative Delirium in Geriatric Patients | Heng, L. Wang, M. Wang, M. Li, L. Zhu, S. | Thorac Cardiovasc Surg | 2022 |
Aged |
| Relationship of sleep disturbance and postoperative delirium: a systematic review and meta-analysis | He, E. Dong, Y. Jia, H. Yu, L. | Gland Surg | 2022 |
Postoperative delirium (PD) |
| Acceptability of transdermal antipsychotic patches by patients who refuse oral medication and their effectiveness in preventing recurrence of delirium: a retrospective observational study | Hatta, K. Usui, C. Nakamura, H. | Int Clin Psychopharmacol | 2022 | |
| Perioperative Hemodynamic Optimization in Patients at Risk for Delirium - A Randomized-Controlled Trial | Fuest, K. E. Servatius, A. Ulm, B. Schaller, S. J. Jungwirth, B. Blobner, M. Schmid, S. | Front Med (Lausanne) | 2022 |
frailty |
| Proposing a Scientific and Technological Approach to the Summaries of Clinical Issues of Inpatient Elderly with Delirium: A Viewpoint | Frisardi, V. Nicolini, M. Cautero, N. Ghirardelli, R. Davolio, F. Haouili, M. Barani, M. | Healthcare (Basel) | 2022 |
delirium |
| Incidence of Drug-Induced Delirium During Treatment With Antidepressants or Antipsychotics: A Drug Surveillance Report of German-Speaking Countries Between 1993 and 2016 | Friedrich, M. E. Grohmann, R. Rabl, U. Winkler, D. Konstantinidis, A. Engel, R. Seifert, J. Toto, S. Stübner, S. Frey, R. Kasper, S. | Int J Neuropsychopharmacol | 2022 |
Adverse Drug Reaction Reporting Systems |
| The inter-relationship between delirium and dementia: the importance of delirium prevention | Fong, T. G. Inouye, S. K. | Nat Rev Neurol | 2022 | |
| Five-Year Outcomes After Implementing a Pain, Agitation, and Delirium Protocol in a Mixed Intensive Care Unit | Fish, J. T. Baxa, J. T. Draheim, R. R. Willenborg, M. J. Mills, J. C. Sticht, L. A. Hankwitz, J. L. Wells, J. A. Jung, H. S. | J Intensive Care Med | 2022 |
Adult |
| Improving Delirium Assessments in Vanderbilt Pediatric and Pediatric Cardiovascular Intensive Care Units | Eken, H. N. Betters, K. A. Fuchs, D. C. Smith, H. A. B. Williams, S. R. | Pediatr Qual Saf | 2022 | |
| Outcomes in Post-operative Delirium Following Bowel Resection: A Single Center Retrospective Review | Desrochers, R. M. Lynch, L. J. Gates, J. D. Ricaurte, D. Wade, J. T. Dicks, R. S. Keating, J. J. | J Surg Res | 2022 |
Bowel |
| Efficacy and Safety of Remimazolam Besylate versus Dexmedetomidine for Sedation in Non-Intubated Older Patients with Agitated Delirium After Orthopedic Surgery: A Randomized Controlled Trial | Deng, Y. Qin, Z. Wu, Q. Liu, L. Yang, X. Ju, X. Zhang, Y. Liu, L. | Drug Des Devel Ther | 2022 |
Benzodiazepines |
| Delirium, changes in cognitive function, and risk of diagnosed dementia after kidney transplantation | Chu, N. M. Bae, S. Chen, X. Ruck, J. Gross, A. L. Albert, M. Neufeld, K. J. Segev, D. L. McAdams-DeMarco, M. A. | Am J Transplant | 2022 |
clinical research/practice |
| Bispectral Index (BIS) Monitoring and Postoperative Delirium in Elderly Patients Undergoing Surgery: A Systematic Review and Meta-Analysis With Trial Sequential Analysis | Chew, W. Z. Teoh, W. Y. Sivanesan, N. Loh, P. S. Shariffuddin,, II Ti, L. K. Ng, K. T. | J Cardiothorac Vasc Anesth | 2022 |
Bis |
| Delirium prevalence in geriatric emergency department patients: A systematic review and meta-analysis | Chen, F. Liu, L. Wang, Y. Liu, Y. Fan, L. Chi, J. | Am J Emerg Med | 2022 |
Aged |
| Improving quantification of anticholinergic burden using the Anticholinergic Effect on Cognition Scale - a healthcare improvement study in a geriatric ward setting | Balasundaram, B. Ang, W. S. T. Stewart, R. Bishara, D. Ooi, C. H. Li, F. Akram, F. Eu Kwek, A. B. | Australas Psychiatry | 2022 |
Aged |
| The Association of Selective Serotonin Reuptake Inhibitors With Delirium in Critically Ill Adults: A Secondary Analysis of the Bringing to Light the Risk Factors and Incidence of Neuropsychologic Dysfunction in ICU Survivors ICU Study | Austin, C. A. Yi, J. Lin, F. C. Pandharipande, P. Ely, E. W. Busby-Whitehead, J. Carson, S. S. | Crit Care Explor | 2022 |
delirium |
| Parental Education and Delirium Risk after Surgery in Older Adults | Arias, F. Chen, F. Shiff, H. Marcantonio, E. R. Jones, R. N. Schmitt, E. M. Metzger, E. Fong, T. G. Travison, T. G. Inouye, S. K. | Clin Gerontol | 2022 |
Childhood socioeconomic status |
| Informing the standardising of care for prolonged stay patients in the ICU: A scoping review of quality improvement tools | Allum, L. Apps, C. Pattison, N. Connolly, B. Rose, L. | Intensive Crit Care Nurs | 2022 |
Bundle |
| Monitoring of nighttime EEG slow-wave activity during dexmedetomidine infusion in patients with hyperactive ICU delirium: An observational pilot study | Ala-Kokko, T. Erikson, K. Koskenkari, J. Laurila, J. Kortelainen, J. | Acta Anaesthesiol Scand | 2022 |
C-trend |
| Development of a Delirium Risk Predication Model among ICU Patients in Oman | Al-Hoodar, R. K. Lazarus, E. R. Alomari, O. Alzaabi, O. | Anesthesiol Res Pract | 2022 | |
| Comparison Between Deltascan Single Channel Electroencephalography (EEG), Confusion Assessment Method-Intensive Care Unit (CAM-ICU) Score and Clinical Assessment in Diagnosing Delirium in Intubated Patients in the Intensive Care Unit | Aben, J. Pouwels, S. Oldenbeuving, A. | Cureus | 2022 |
cam-icu |
| A Cross-Sectional Survey on the Clinical Management of Emergence Delirium in Adults: Knowledge, Attitudes, and Practice in Mainland China | Yuan, Y. Lei, B. Li, Z. Wang, X. Zhao, H. Gao, M. Xue, Y. Zhang, W. Xiao, R. Meng, X. Zheng, H. Zhang, J. Wang, G. Guo, X. | Brain Sci | 2022 |
Pacu |
| Development and Validation of a Nomogram for Predicting Postoperative Delirium in Patients With Elderly Hip Fracture Based on Data Collected on Admission | Yang, Y. Wang, T. Guo, H. Sun, Y. Cao, J. Xu, P. Cai, Y. | Front Aging Neurosci | 2022 |
albumin |
| Preoperative Inflammatory Markers and the Risk of Postoperative Delirium in Patients Undergoing Lumbar Spinal Fusion Surgery | Yang, J. S. Lee, J. J. Kwon, Y. S. Kim, J. H. Sohn, J. H. | J Clin Med | 2022 |
CRP-to-albumin ratio |
| An association between cancer type and delirium incidence in Japanese elderly patients: A retrospective longitudinal study | Yamato, K. Ikeda, A. Endo, M. Filomeno, R. Kiyohara, K. Inada, K. Nishimura, K. Tanigawa, T. | Cancer Med | 2022 |
cancer |
| Increased Direct Current-Electroencephalography Shifts During Induction of Anesthesia in Elderly Patients Developing Postoperative Delirium | Windmann, V. Dreier, J. P. Major, S. Spies, C. Lachmann, G. Koch, S. | Front Aging Neurosci | 2022 |
*dc-eeg |
| Risk factors of delirium after gastrointestinal surgery: A meta-analysis | Wang, X. Yu, D. Du, Y. Geng, J. | J Clin Nurs | 2022 |
delirium |
| Physician Experience Design (PXD): More Usable Machine Learning Prediction for Clinical Decision Making | Wang, L. Chignell, M. Zhang, Y. Pinto, A. Razak, F. Sheehan, K. Verma, A. | AMIA Annu Symp Proc | 2022 |
Artificial Intelligence |
| The Relationship Between Cardiovascular Disease Risk Score and Postoperative Delirium: The PNDABLE Study | Wang, J. Wang, L. Tang, X. Wang, F. Liu, S. Wu, X. Dong, R. Lin, X. Wang, B. Bi, Y. | Front Aging Neurosci | 2022 |
biomarkers |
| Preoperative intervention to prevent delirium in patients with hip fracture - a systematic review | Virsøe-Frandsen, C. D. Skjold, C. Wildgaard, K. Møller, A. M. | Dan Med J | 2022 |
Aged |
| Coexisting delirium and excited catatonia | Vellanki, K. D. Carroll, B. T. | Ann Clin Psychiatry | 2022 |
*Antipsychotic Agents/therapeutic use |