What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Incidence of Postoperative Delirium Is Similar with Regional and General Anesthesia | Rosenberg, K. | Am J Nurs | 2022 |
Aged |
| Delirium and Delirium Severity Predict the Trajectory of the Hierarchical Assessment of Balance and Mobility in Hospitalized Older People: Findings From the DECIDE Study | Richardson, S. Murray, J. Davis, D. Stephan, B. C. M. Robinson, L. Brayne, C. Barnes, L. Parker, S. Sayer, A. A. Dodds, R. M. Allan, L. | J Gerontol A Biol Sci Med Sci | 2022 |
Aged |
| Anesthetic Practice Trends and Perceptions Toward Postoperative Delirium: A Mixed-Methods Analysis | Ragheb, J. Norcott, A. E. Iskander, M. Brooks, J. McKinney, A. Mentz, G. Vlisides, P. E | Anesth Analg | 2022 | |
| Preoperative Vitamin D Deficiency Is Associated With Postoperative Delirium in Critically Ill Patients | Qiu, Y. Sessler, D. I. Chen, L. Halvorson, S. Cohen, B. Bravo, M. Ince, I. Maheshwari, K. Kurz, A. | J Intensive Care Med | 2022 |
Adult |
| Physicians' beliefs and attitudes toward hypoactive delirium in the last days of life | Oya, K. Morita, T. Tagami, K. Matsuda, Y. Naito, A. S. Kashiwagi, H. Otani, H. | J Pain Symptom Manage | 2022 |
antipsychotic |
| Evidence-Based Guideline on Management of Postoperative Delirium in Older People for Low Resource Setting: Systematic Review Article | Mossie, A. Regasa, T. Neme, D. Awoke, Z. Zemedkun, A. Hailu, S. | Int J Gen Med | 2022 |
delirium prevention |
| Delirium diagnosis without a gold standard: Evaluating diagnostic accuracy of combined delirium assessment tools | Moss, S. J. Hee Lee, C. Doig, C. J. Whalen-Browne, L. Stelfox, H. T. Fiest, K. M. | PLoS One | 2022 |
Adult |
| Steroid dosing and delirium after lung transplant surgery | Mody, G. N. Choi, B. Townsend, K. Kerwin, C. Larios, D. Boukedes, S. Coppolino, A. Singh, S. Jin, G. Wolfe, D. Mallidi, H. Goldberg, H. | Gen Hosp Psychiatry | 2022 |
*Delirium/etiology |
| A systematic review of strategies for preventing delirium in patients undergoing vascular surgery | Meulenbroek, A. L. van Mil, S. R. Faes, M. C. Mattace-Raso, F. U. S. Fourneau, I. van der Laan, L. | Ann Vasc Surg | 2022 |
Aneurysm of the abdominal aorta |
| The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement | Messé, S. R. Overbey, J. R. Thourani, V. H. Moskowitz, A. J. Gelijns, A. C. Groh, M. A. Mack, M. J. Ailawadi, G. Furie, K. L. Southerland, A. M. James, M. L. Moy, C. S. Gupta, L. Voisine, P. Perrault, L. P. Bowdish, M. E. Gillinov, A. M. O'Gara, P. T. Ou | J Thorac Cardiovasc Surg | 2022 |
aortic valve |
| Tau as a serum biomarker of delirium after major cardiac surgery: a single centre case-control study | McKay, T. B. Qu, J. Liang, F. Mueller, A. Wiener-Kronish, J. Xie, Z. Akeju, O. | Br J Anaesth | 2022 |
Alzheimer’s disease |
| Insulinoma: an uncommon cause of delirium | McComb, K. Roulston, G. Armstrong, L. | Age Ageing | 2022 |
Aged |
| The Twilight Zone: Oxybutynin Overuse Exacerbating Delirium | Marthi, S. Pomerantz, M. A. Mernan, A. J. Berlow, Y. A. | J Geriatr Psychiatry Neurol | 2022 |
anticholinergic medications |
| Corrigendum: Risk Factors for Delirium Are Different in the Very Old: A Comparative One-Year Prospective Cohort Study of 5,831 Patients | Marquetand, J. Bode, L. Fuchs, S. Hildenbrand, F. Ernst, J. von Känel, R. Boettger, S. | Front Psychiatry | 2022 |
comparison |
| The development of the MENTOR_D nursing intervention: Supporting family involvement in delirium management | Mailhot, T. Cossette, S. Lavoie, P. Maheu-Cadotte, M. A. Fontaine, G. Bourbonnais, A. Côté, J. | Int J Older People Nurs | 2022 |
delirium |
| Factors Associated With Severity of Delirium Complicating COVID-19 in Intensive Care Units | Madonna, D. Enrico, P. Ciappolino, V. Boscutti, A. Colombo, E. Turtulici, N. Cantù, F. Cereda, G. Delvecchio, G. De Falco, S. Chierichetti, M. Savioli, M. Grasselli, G. Brambilla, P. | Front Neurol | 2022 |
Ards |
| An open-label clinical trial of oral transmucosal haloperidol and oral transmucosal olanzapine in the treatment of terminal delirium at home | Lyu, X. J. Kan, A. D. Chong, P. H. Lin, K. Koh, Y. H. Yeo, Z. Z. | Trials | 2022 |
*Antipsychotic Agents/adverse effects |
| Family-centred care interventions to reduce the delirium prevalence in critically ill patients: A systematic review and meta-analysis | Lin, L. Peng, Y. Zhang, H. Huang, X. Chen, L. Lin, Y. | Nurs Open | 2022 |
delirium |
| White-Cell Derived Inflammatory Biomarkers in Prediction of Postoperative Delirium in Elderly Patients Undergoing Surgery for Lower Limb Fracture Under Non-General Anaesthesia | Li, X. Wang, G. He, Y. Wang, Z. Zhang, M. | Clin Interv Aging | 2022 |
Aged |
| Comparative salary-related costs of a brief app-directed delirium identification protocol by hospitalists, nurses, and nursing assistants | Leslie, D. L. Fick, D. M. Moore, A. Inouye, S. K. Jung, Y. Ngo, L. H. Boltz, M. Husser, E. Shrestha, P. Boustani, M. Marcantonio, E. R. | J Am Geriatr Soc | 2022 |
cost-analysis |
| Investigation and treatment of asymptomatic bacteriuria in older patients with delirium: a cross-sectional survey of Canadian physicians | Laguë, A. Boucher, V. Joo, P. Yadav, K. Morasse, C. Émond, M. | Cjem | 2022 |
Aged |
| APOE e4 Genotypes Increase Risk of Delirium During COVID-19-Related Hospitalizations: Evidence From a Large UK Cohort | Kuo, C. L. Pilling, L. C. Atkins, J. L. Fortinsky, R. H. Kuchel, G. A. Melzer, D. | J Gerontol A Biol Sci Med Sci | 2022 |
Alleles |
| Nurses' Knowledge about Delirium in the Group of Intensive Care Units Patients | Krupa, S. Friganović, A. Oomen, B. Benko, S. Mędrzycka-Dąbrowska, W. | Int J Environ Res Public Health | 2022 |
Clinical Competence |
| Early Ambulation to Prevent Delirium After Long-Time Head and Neck Cancer Surgery | Kim, J. H. Lee, Y. S. Kim, Y. H. Cho, K. J. Jung, Y. H. Choi, S. H. Nam, S. Y. Kim, S. Y. | Front Surg | 2022 |
ambulation |
| The effect of regional nerve block on perioperative delirium in hip fracture surgery for the elderly: A systematic review and meta-analysis of randomized controlled trials | Kim, C. H. Yang, J. Y. Min, C. H. Shon, H. C. Kim, J. W. Lim, E. J. | Orthop Traumatol Surg Res | 2022 |
Aged |
| Role of multicomponent non-pharmacological nursing interventions on delirium prevention: A randomized controlled study | Kasapoğlu, E. S. Enç, N. | Geriatr Nurs | 2022 |
Critical Illness |
| Early Intervention of Perioperative Delirium in Older Patients (>60 years) with Hip Fracture: A Randomized Controlled Study | Jing, G. W. Xie, Q. Tong, J. Liu, L. Z. Jiang, X. Si, L. | Orthop Surg | 2022 |
Delirium |
| Functional Outcome in Patients with Chronic Subdural Hematoma: Postoperative Delirium and Operative Procedure | Ishida, T. Inoue, T. Inoue, T. Saito, A. Suzuki, S. Uenohara, H. Tominaga, T. | Neurol Med Chir (Tokyo) | 2022 |
*Delirium/etiology |
| Delirium in geriatric patients | Iglseder, B. Frühwald, T. Jagsch, C. | Wien Med Wochenschr | 2022 |
Aged |
| Recognizing Intensive Care Unit Delirium: Are Critical Care Nurses Ready? | Ho, M. H. Chang, H. R. Liu, M. F. Chen, K. H. Shen Hsiao, S. T. Traynor, V. | J Nurs Res | 2022 | |
| Effect of an evidence-based poster on the knowledge of delirium and its prevention in student nurses: A quasi-experimental study | Glass, G. F. Tan, H. Chan, E. Y. | Contemp Nurse | 2022 |
Aged |
| Lack of Association Between Perioperative Medication and Postoperative Delirium in Hip Fracture Patients in an Orthogeriatric Care Pathway | Genet, B. Lamy, T. Cohen-Bittan, J. Glasman, P. Verny, M. Riou, B. Boddaert, J. Zerah, L. | J Am Med Dir Assoc | 2022 |
Aged |
| Dexmedetomidine after Cardiac Surgery for Prevention of Delirium (EXACTUM) trial protocol: a multicentre randomised, double-blind, placebo-controlled trial | Gargadennec, T. Oilleau, J. F. Rozec, B. Nesseler, N. Lasocki, S. Futier, E. Amour, J. Durand, M. Bougle, A. Kerforne, T. Consigny, M. Eddi, D. Huet, O. | BMJ Open | 2022 |
Aged |
| Validation of E-PRE-DELIRIC in cardiac surgical ICU delirium: A retrospective cohort study | Gao, W. Zhang, Y. Jin, J. | Nurs Crit Care | 2022 |
Adult |
| Association Between Sedative Medication Administration and Delirium Development in a Medical Intensive Care Unit | Franz, N. D. Alaniz, C. Miller, J. T. Farina, N. | J Pharm Pract | 2022 |
benzodiazepine |
| Nurse-Driven Assessment, Prevention, and Management of Delirium on an Acute Inpatient Neurology Unit | Francisco, M. A. Gesell, T. Meletis, S. Bohr, N. L. Gleason, L. J. | J Nurs Care Qual | 2022 | |
| Delirium the next frontier | Fong, T. G. Inouye, S. K. | J Gerontol A Biol Sci Med Sci | 2022 |
*Delirium/diagnosis/etiology |
| Presurgical Thalamus Volume in Postoperative Delirium: A Longitudinal Observational Cohort Study in Older Patients | Fislage, M. Feinkohl, I. Pischon, T. Spies, C. D. Borchers, F. Winterer, G. Zacharias, N. | Anesth Analg | 2022 | |
| The association between preoperative Mini-Cog© score and postoperative delirium (POD): a retrospective cohort study | Fiamanya, S. Ma, S. Yates, D. R. A. | Perioper Med (Lond) | 2022 |
Cognitive impairment |
| Delirium severity in critical patients with COVID-19 from an Infectious Disease Intensive Care Unit | Dias, R. Caldas, J. P. Silva-Pinto, A. Costa, A. Sarmento, A. Santos, L. | Int J Infect Dis | 2022 |
*COVID-19/complications |
| Health-Related Quality of Life Following Delirium in the PICU | Dervan, L. A. Killien, E. Y. Smith, M. B. Watson, R. S. | Pediatr Crit Care Med | 2022 |
Aftercare |
| Cuartas, C. F. Davis, M. | Valproic Acid in the Management of Delirium | Am J Hosp Palliat Care | 2022 |
Adult |
| Assessing the Accuracy of International Classification of Diseases (ICD) Coding for Delirium | Chuen, V. L. Chan, A. C. H. Ma, J. Alibhai, S. M. H. Chau, V. | J Appl Gerontol | 2022 |
*Delirium/diagnosis |
| Evaluation of the Impact of Prior-to-Admission Sleep Aid Prescribing Practices on Sleep and Delirium in the Intensive Care Unit | Chudow, M. Paradiso, V. Silva, N. Collette, J. | Ann Pharmacother | 2022 |
Adult |
| Chou, S. T. Pogach, M. Rock, L. K. | Less pharmacotherapy is more in delirium | Intensive Care Med | 2022 | |
| A randomized trial: bispectral-guided anesthesia decreases incidence of delayed neurocognitive recovery and postoperative neurocognitive disorder but not postoperative delirium | Chen, X. Li, L. Yang, L. Li, A. Wu, M. Yu, D. | Am J Transl Res | 2022 |
BIS monitoring |
| Comparative effectiveness of non-pharmacological interventions for preventing delirium in critically ill adults: A systematic review and network meta-analysis | Chen, T. J. Traynor, V. Wang, A. Y. Shih, C. Y. Tu, M. C. Chuang, C. H. Chiu, H. Y. Chang, H. R. | Int J Nurs Stud | 2022 |
Delirium |
| Influence of Renin-Angiotensin System Inhibitors on Postoperative Delirium in Patients With Pulmonary Arterial Hypertension: A Secondary Analysis of a Retrospective Cohort Study | Chen, G. Zhou, S. Deng, F. | Front Psychiatry | 2022 |
ACEIs |
| Delirium in COVID‑19 pneumonia: looking inside the geriatric unit-reply | Callea, A. Conti, G. Caporotundo, S. Della Marca, G. Rollo, E. | Intern Emerg Med | 2022 | |
| Postoperative delirium in the elderly: time to focus on pre- and postoperative management | Bruder, N. | Minerva Anestesiol | 2022 |
Aged |
| Improving ABCDEF Bundle Compliance and Clinical Outcomes in the ICU: Randomized Control Trial to Assess the Impact of Performance Measurement, Feedback, and Data Literacy Training | Brown, J. C. Querubin, J. A. Ding, L. Mack, W. J. Chen-Chan, K. Perez, F. Barr, J. Peden, C. J. Cobb, J. P. | Crit Care Explor | 2022 |
ABCDEF bundle compliance |
| Impact of Cerebral Embolic Protection Devices on the Incidence and Outcomes of Delirium After Transcatheter Aortic Valve Implantation | Bansal, A. Kumar, A. Reed, G. W. Puri, R. Krishnaswamy, A. Linke, A. Yun, J. Kapadia, S. R. | Am J Cardiol | 2022 | |
| Postoperative delirium in older patients after undergoing pelvic organ prolapse surgery | Ackenbom, M. F. Zyczynski, H. M. Butters, M. A. Lopa, S. Orris, S. R. Davis, E. M. | nt Urogynecol J | 2022 |
Cognitive impairment |
| Use of naldemedine is associated with reduced incidence of hyperactive delirium in cancer patients with opioid-induced constipation: a nationwide retrospective cohort study in Japan | Abe, H. Sumitani, M. Matsui, H. Inoue, R. Fushimi, K. Uchida, K. Yasunaga, H. | Pharmacotherapy | 2022 |
delirium |
| Effect of light therapy on delirium in older patients with Alzheimer's disease-related dementia | Zou, C. Mei, X. Li, X. Hu, J. Xu, T. Zheng, C. | J Psychiatr Res | 2022 |
Alzheimer’s disease |
| Association of antipsychotic dose with survival of advanced cancer patients with delirium | Yokomichi, N. Maeda, I. Morita, T. Yoshiuchi, K. Ogawa, A. Hisanaga, T. Sakashita, A. Nakahara, R. Kaneishi, K. Iwase, S. | Ann Palliat Med | 2022 |
Advanced cancer |
| Systematic review and meta-analysis on the incidence of delirium in intensive care unit inpatients after cognitive exercise intervention | Xu, C. Chen, Z. Zhang, L. Guo, H. | Ann Palliat Med | 2022 |
Cognition |
| Electroencephalography in delirium assessment: a scoping review | Wiegand, T. L. T. Rémi, J. Dimitriadis, K. | BMC Neurol | 2022 |
*Delirium/diagnosis/etiology |
| Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial | Wibrow, B. Martinez, F. E. Myers, E. Chapman, A. Litton, E. Ho, K. M. Regli, A. Hawkins, D. Ford, A. van Haren, F. M. P. Wyer, S. McCaffrey, J. Rashid, A. Kelty, E. Murray, K. Anstey, M. | Intensive Care Med | 2022 |
Australia |
| Effect of Electroencephalography Spectral Edge Frequency (SEF) and Patient State Index (PSI)-Guided Propofol-Remifentanil Anesthesia on Delirium After Laparoscopic Surgery: The eMODIPOD Randomized Controlled Trial | Wang, E. Wang, L. Ye, C. Luo, N. Zhang, Y. Zhong, Y. Zhu, M. Zou, Y. Li, Q. Li, L. Song, Z. Luo, H. Dai, F. Liu, H. Gelb, A. W. Guo, Q. Meng, L. | J Neurosurg Anesthesiol | 2022 |
*Anesthesia/adverse effects |
| Hospitalisation costs and Health Related Quality of Life in delirious patients; a scoping review | van Lieshout, C. Schuit, E. Hermes, C. Kerrigan, M. Frederix, G. W. J. | Z Evid Fortbild Qual Gesundhwes | 2022 |
Cost Analysis |
| Rapid cognitive assessment tools for screening of mild cognitive impairment in the preoperative setting: A systematic review and meta-analysis | Tran, J. Nimojan, T. Saripella, A. Tang-Wai, D. F. Butris, N. Kapoor, P. Berezin, L. Englesakis, M. Chung, F. | J Clin Anesth | 2022 |
Cognition |
| Physostigmine for Facilitation of Care in Clozapine-Associated Anticholinergic Delirium | Spring, J. D. Goldstein, B. N. Buster, M. Mahmoud, A. A. Hamm, B. | J Clin Psychopharmacol | 2022 | |
| Relationship between no-visitation policy and the development of delirium in patients admitted to the intensive care unit | Shinohara, F. Unoki, T. Horikawa, M. | PLoS One | 2022 |
Apache |
| USING A REAL-TIME ABCDEF COMPLIANCE TOOL TO UNDERSTAND THE ROLE OF BUNDLE ELEMENTS IN MORTALITY AND DELIRIUM | Shampo, J. C. Wenszell, K. Luo-Owen, X. Mukherjee, N. Cochran-Yu, M. Swentek, L. Burruss, S. K. Markovich, S. Turay, D. Dorotta, I. R. Mukherjee, K. | J Trauma Acute Care Surg | 2022 | |
| Post-discharge Mortality in Patients With Delirium and Dementia: A 3-Year Follow Up Study | Schnorr, T. Fleiner, T. Schroeder, H. Reupke, I. Woringen, F. Trumpf, R. Schroeder, S. Zijlstra, W. Haussermann, P. | Front Psychiatry | 2022 |
aftercare |
| Effects of Physical Exercise on the Incidence of Delirium and Cognitive Function in Acutely Hospitalized Older Adults: A Systematic Review with Meta-Analysis | Sáez de Asteasu, M. L. Cuevas-Lara, C. García-Hermoso, A. Ramírez-Vélez, R. Martínez-Velilla, N. Zambom-Ferraresi, F. Cadore, E. L. Izquierdo, M. | J Alzheimers Dis | 2022 |
Physical exercise |
| Associations Between Stroke Localization and Delirium: A Systematic Review and Meta-Analysis | Rhee, J. Y. Colman, M. A. Mendu, M. Shah, S. J. Fox, M. D. Rost, N. S. Kimchi, E. Y. | J Stroke Cerebrovasc Dis | 2022 |
*Delirium/epidemiology |
| The family in preventing delirium in the intensive care unit: Scoping review | Pabón-Martínez, B. A. Rodríguez-Pulido, L. I. Henao-Castaño, A. M. | Enferm Intensiva (Engl Ed) | 2022 |
Adult |
| The effect of delirium preventive measures on the occurrence of postoperative cognitive dysfunction in older adults undergoing cardiovascular surgery. The DelPOCD randomised controlled trial | Olotu, C. Ascone, L. Wiede, J. Manthey, J. Kuehn, S. Scherwath, A. Kiefmann, R. | J Clin Anesth | 2022 |
Aged |
| Pharmacotherapy for elderly patients with delirium in a general ward setting: A retrospective study | Ohsako, N. Hashimoto, T. Shiko, Y. Kawasaki, Y. Nakagawa, M. Okuma, T. Kurata, T. Suzuki, H. Ishige, M. Kikuchi, S. | Asian J Psychiatr | 2022 |
Aged |
| Regional cerebral hypometabolism on 18F-FDG PET/CT scan in delirium is independent of acute illness and dementia | Nitchingham, A. Pereira, J. V. Wegner, E. A. Oxenham, V. Close, J. Caplan, G. A. | Alzheimers Dement | 2022 |
18F-fluorodeoxyglucose positron emission tomography |
| Delirium screening with 4AT in patients aged 65 years and older admitted to the Emergency Department with suspected sepsis: a prospective cohort study | Myrstad, M. Kuwelker, K. Haakonsen, S. Valebjørg, T. Langeland, N. Kittang, B. R. Hagberg, G. Neerland, B. E. Bakken, M. S. | Eur Geriatr Med | 2022 |
Aged |
| The DEMS-DOSS study: validating a delirium monitoring tool in hospitalised older adults | Montgomery, A. Todd, J. A. Jones, C. Koroitamana, J. Grealish, L. Wand, A. Billett, S. Teodorczuk, A. | Age Ageing | 2022 |
Aged |
| Effectiveness of Interprofessional Consultation-Based Interventions for Delirium: A Scoping Review | Monaghan, C. Martin, G. Kerr, J. Peters, M. L. Versloot, J. | J Appl Gerontol | 2022 |
Accidental Falls/prevention & control |
| PRe-Operative Prediction of postoperative DElirium by appropriate SCreening (PROPDESC) development and validation of a pragmatic POD risk screening score based on routine preoperative data | Menzenbach, J. Kirfel, A. Guttenthaler, V. Feggeler, J. Hilbert, T. Ricchiuto, A. Staerk, C. Mayr, A. Coburn, M. Wittmann, M. | J Clin Anesth | 2022 |
*Delirium/diagnosis/epidemiology/etiology |
| Behavioral Variant Frontotemporal Dementia and Social and Criminal Transgressions | Mendez, M. F. | J Neuropsychiatry Clin Neurosci | 2022 |
Cognition |
| Effects of Abdominal Wall Blocks on Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Surgery: A Randomized Controlled Study | Liu, T. Tuo, J. Wei, Q. Sun, X. Zhao, H. Zhao, X. Qu, M. | Med Sci Monit | 2022 |
Aged |
| Preoperative Status of Gut Microbiota Predicts Postoperative Delirium in Patients With Gastric Cancer | Liu, H. Cheng, G. Xu, Y. L. Fang, Q. Ye, L. Wang, C. H. Liu, X. S. | Front Psychiatry | 2022 |
Shigella |
| Nurses' experiences in the management of delirium among older persons in acute care ward settings: A qualitative systematic review and meta-aggregation | Lim, X. M. Lim, Z. H. T. Ignacio, J. | Int J Nurs Stud | 2022 |
Aged |
| Predicting hospital mortality and length of stay: A prospective cohort study comparing the Intensive Care Delirium Screening Checklist versus Confusion Assessment Method for the Intensive Care Unit | Li, H. C. Chen, C. C. Yeh, T. Y. Liao, S. C. Hsu, A. S. Wei, Y. C. Shun, S. C. Ku, S. C. Inouye, S. K. | Aust Crit Care | 2022 |
CAM-ICU (Confusion Assessment Method for Intensive Care Unit) |
| Can we improve delirium prevention and treatment in the emergency department? A systematic review | Lee, S. Chen, H. Hibino, S. Miller, D. Healy, H. Lee, J. S. Arendts, G. Han, J. H. Kennedy, M. Carpenter, C. R. | J Am Geriatr Soc | 2022 |
delirium |
| Prevalence, management and outcomes of unrecognized delirium in a National Sample of 1,493 older emergency department patients: how many were sent home and what happened to them? | Lee, J. S. Tong, T. Chignell, M. Tierney, M. C. Goldstein, J. Eagles, D. Perry, J. J. McRae, A. Lang, E. Hefferon, D. Rose, L. Kiss, A. Borgundvaag, B. McLeod, S. Melady, D. Boucher, V. Sirois, M. J. Émond, M. | Age Aging | 2022 |
*Aftercare |
| COVID-19 severity and age increase the odds of delirium in hospitalized adults with confirmed SARS-CoV-2 infection: a cohort study | LaHue, S. C. Escueta, D. P. Guterman, E. L. Patel, K. Harrison, K. L. Boscardin, W. J. Douglas, V. C. Newman, J. C. | BMC Psychiatry | 2022 |
Adult |
| Outcomes in heart failure patients discharged to skilled nursing facilities with delirium | Lafo, J. Singh, M. Jiang, L. Correia, S. Madrigal, C. Clements, R. Wu, W. C. Erqou, S. Rudolph, J. L. | ESC Heart Fail | 2022 |
Delirium |
| Distribution of delirium motor subtypes in the intensive care unit: a systematic scoping review | la Cour, K. N. Andersen-Ranberg, N. C. Weihe, S. Poulsen, L. M. Mortensen, C. B. Kjer, C. K. W. Collet, M. O. Estrup, S. Mathiesen, O. | Crit Care | 2022 |
Aged |
| Factors associated with post-operative delirium in hip fracture patients: what should we care | Kong, D. Luo, W. Zhu, Z. Sun, S. Zhu, J. | Eur J Med Res | 2022 |
Aged |
| Factors Associated With Postoperative Delirium in Patients Undergoing Complex Head and Neck Flap Surgery | Kolk, A. Schwarzer, C. Wolff, K. D. Grill, F. Weingart, J. | J Oral Maxillofac Surg | 2022 |
Adolescent |
| Increased postoperative myeloperoxidase concentration associated with low baseline antioxidant capacity as the risk factor of delirium after cardiac surgery | Kaźmierski, J. Miler, P. Pawlak, A. Jerczyńska, H. Nowakowska, K. Walkiewicz, G. Woźniak, K. Krejca, M. Wilczyński, M. | Ann Med | 2022 |
Antioxidants |
| Could neutrophil-to-lymphocyte ratio predict mortality in community-dwelling older people with delirium superimposed on dementia? | Katipoglu, B. Naharci, M. I. | Aging Clin Exp Res | 2022 |
Delirium |
| The efficacy and safety of nurse-initiated sedation management in an intensive care unit: A two-phase prospective study in Japan | Kanda, N. Nakano, H. Naraba, H. Kawasaki, A. Ohno, N. Yoshikawa, Y. Sakuramoto, H. Takahashi, Y. Sonoo, T. Hashimoto, H. Nakamura, K. | Jpn J Nurs Sci | 2022 |
Richmond Agitation-Sedation Scale |
| Albumin/fibrinogen ratio, an independent risk factor for postoperative delirium after total joint arthroplasty | Jiang, L. Lei, G. | Geriatr Gerontol Int | 2022 |
albumin/fibrinogen ratio |
| Association of preoperative vitamin D deficiency with the risk of postoperative delirium and cognitive dysfunction: A meta-analysis | Hung, K. C. Wang, L. K. Lin, Y. T. Yu, C. H. Chang, C. Y. Sun, C. K. Chen, J. Y. | J Clin Anesth | 2022 |
Postoperative cognitive dysfunction |
| Sailing in a sea of perplexity: Family caregivers' experience of patients with delirium | Huang, L. J. Tsai, H. H. Wang, Y. W. Chou, C. L. | Nurs Crit Care | 2022 |
*Caregivers |
| Association Between Hypernatremia and Delirium After Cardiac Surgery: A Nested Case-Control Study | Hong, L. Shen, X. Shi, Q. Song, X. Chen, L. Chen, W. Chen, S. Xue, Y. Zhang, C. Zhou, J. | Front Cardiovasc Med | 2022 |
cardiac surgery |
| Harmonization of Four Delirium Instruments: Creating Crosswalks and the Delirium Item-Bank (DEL-IB) | Helfand, B. K. I. Detroyer, E. Milisen, K. Adamis, D. Metzger, E. D. Boudreaux, E. D. Inouye, S. K. Jones, R. N. | Am J Geriatr Psychiatry | 2022 |
Aged |
| Does delirium prevention reduce risk of in-patient falls among older adults? A systematic review and trial sequential meta-analysis | He, S. Rolls, K. Stott, K. Shekhar, R. Vueti, V. Flowers, K. Moseley, M. Shepherd, B. Mayahi-Neysi, M. Chasle, B. Warner, B. Ni Chroinin, D. Frost, S. A. | Australas J Ageing | 2022 |
accidental falls |
| Detection of delirium by family members in the intensive care unit: Translation, Cross-Cultural adaptation and validation of the Family Confusion Assessment Method for the German-Speaking area | Greindl, S. Weiss, B. Magnolini, R. Lingg, C. Mayer, H. Schaller, S. J. | J Adv Nurs | 2022 |
Family Confusion Assessment Method |
| Patient-related risk factors for in-hospital functional decline in older adults: A systematic review and meta-analysis | Geyskens, L. Jeuris, A. Deschodt, M. Van Grootven, B. Gielen, E. Flamaing, J. | Age Ageing | 2022 |
*Activities of Daily Living |
| Screening for delirium and dementia in older hospitalised adults in Zambia | George, G. Fricker, M. Todd, O. Makowa, D. Tembo, C. Dotchin, C. Gray, W. K. Walker, R. W. Mbwele, B. Paddick, S. M. | J Neurol Sci | 2022 |
Delirium |