What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.
- Authors
- Miller, D. Lewis, S. R. Pritchard, M. W. Schofield-Robinson, O. J. Shelton, C. L. Alderson, P. Smith, A. F.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
BACKGROUND: The use of anaesthetics in the elderly surgical population (more than 60 years of age) is increasing. Postoperative delirium, an acute condition characterized by reduced awareness of the environment and a disturbance in attention, typically occurs between 24 and 72 hours after surgery and can affect up to 60% of elderly surgical patients. Postoperative cognitive dysfunction (POCD) is a new-onset of cognitive impairment which may persist for weeks or months after surgery.Traditionally, surgical anaesthesia has been maintained with inhalational agents. End-tidal concentrations require adjustment to balance the risks of accidental awareness and excessive dosing in elderly people. As an alternative, propofol-based total intravenous anaesthesia (TIVA) offers a more rapid recovery and reduces postoperative nausea and vomiting. Using TIVA with a target controlled infusion (TCI) allows plasma and effect-site concentrations to be calculated using an algorithm based on age, gender, weight and height of the patient.TIVA is a viable alternative to inhalational maintenance agents for surgical anaesthesia in elderly people. However, in terms of postoperative cognitive outcomes, the optimal technique is unknown. OBJECTIVES: To compare maintenance of general anaesthesia for elderly people undergoing non-cardiac surgery using propofol-based TIVA or inhalational anaesthesia on postoperative cognitive function, mortality, risk of hypotension, length of stay in the postanaesthesia care unit (PACU), and hospital stay. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2017, Issue 11), MEDLINE (1946 to November 2017), Embase (1974 to November 2017), PsycINFO (1887 to November 2017). We searched clinical trials registers for ongoing studies, and conducted backward and forward citation searching of relevant articles. SELECTION CRITERIA: We included randomized controlled trials (RCTs) with participants over 60 years of age scheduled for non-cardiac surgery under general anaesthesia. We planned to also include quasi-randomized trials. We compared maintenance of anaesthesia with propofol-based TIVA versus inhalational maintenance of anaesthesia. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed studies for inclusion, extracted data, assessed risk of bias, and synthesized findings. MAIN RESULTS: We included 28 RCTs with 4507 randomized participants undergoing different types of surgery (predominantly cardiovascular, laparoscopic, abdominal, orthopaedic and ophthalmic procedures). We found no quasi-randomized trials. Four studies are awaiting classification because we had insufficient information to assess eligibility.All studies compared maintenance with propofol-based TIVA versus inhalational maintenance of anaesthesia. Six studies were multi-arm and included additional TIVA groups, additional inhalational maintenance or both. Inhalational maintenance agents included sevoflurane (19 studies), isoflurane (eight studies), and desflurane (three studies), and was not specified in one study (reported as an abstract). Some studies also reported use of epidural analgesia/anaesthesia, fentanyl and remifentanil.We found insufficient reporting of randomization methods in many studies and all studies were at high risk of performance bias because it was not feasible to blind anaesthetists to study groups. Thirteen studies described blinding of outcome assessors. Three studies had a high of risk of attrition bias, and we noted differences in the use of analgesics between groups in six studies, and differences in baseline characteristics in five studies. Few studies reported clinical trials registration, which prevented assessment of risk of selective reporting bias.We found no evidence of a difference in incidences of postoperative delirium according to type of anaesthetic maintenance agents (odds ratio (OR) 0.59, 95% confidence interval (CI) 0.15 to 2.26; 321 participants; five studies; very low-certainty evidence); we noted during sensitivity analysis that using different time points in one study may influence direction of this result. Thirteen studies (3215 participants) reported POCD, and of these, six studies reported data that could not be pooled; we noted no difference in scores of POCD in four of these and in one study, data were at a time point incomparable to other studies. We excluded one large study from meta-analysis because study investigators had used non-standard anaesthetic management and this study was not methodologically comparable to other studies. We combined data for seven studies and found low-certainty evidence that TIVA may reduce POCD (OR 0.52, 95% CI 0.31 to 0.87; 869 participants).We found no evidence of a difference in mortality at 30 days (OR 1.21, 95% CI 0.33 to 4.45; 271 participants; three studies; very low-certainty evidence). Twelve studies reported intraoperative hypotension. We did not perform meta-analysis for 11 studies for this outcome. We noted visual inconsistencies in these data, which may be explained by possible variation in clinical management and medication used to manage hypotension in each study (downgraded to low-certainty evidence); one study reported data in a format that could not be combined and we noted little or no difference between groups in intraoperative hypotension for this study. Eight studies reported length of stay in the PACU, and we did not perform meta-analysis for seven studies. We noted visual inconsistencies in these data, which may be explained by possible differences in definition of time points for this outcome (downgraded to very low-certainty evidence); data were unclearly reported in one study. We found no evidence of a difference in length of hospital stay according to type of anaesthetic maintenance agent (mean difference (MD) 0 days, 95% CI -1.32 to 1.32; 175 participants; four studies; very low-certainty evidence).We used the GRADE approach to downgrade the certainty of the evidence for each outcome. Reasons for downgrading included: study limitations, because some included studies insufficiently reported randomization methods, had high attrition bias, or high risk of selective reporting bias; imprecision, because we found few studies; inconsistency, because we noted heterogeneity across studies. AUTHORS’ CONCLUSIONS: We are uncertain whether maintenance with propofol-based TIVA or with inhalational agents affect incidences of postoperative delirium, mortality, or length of hospital stay because certainty of the evidence was very low. We found low-certainty evidence that maintenance with propofol-based TIVA may reduce POCD. We were unable to perform meta-analysis for intraoperative hypotension or length of stay in the PACU because of heterogeneity between studies. We identified 11 ongoing studies from clinical trials register searches; inclusion of these studies in future review updates may provide more certainty for the review outcomes.
- PMID
- Keywords
Aged
Anesthesia, Inhalation
Anesthesia, Intravenous
Anesthetics, Inhalation
Anesthetics, Intravenous/*adverse effects
Cognition/*drug effects
Cognition Disorders/chemically induced
Delirium/chemically induced
Desflurane
Humans
Hypotension/chemically induced
Isoflurane/adverse effects/analogs & derivatives
Methyl Ethers/adverse effects
Middle Aged
Postoperative Complications/chemically induced/mortality
Propofol/*adverse effects
Randomized Controlled Trials as Topic
Sevoflurane
*Surgical Procedures, Operative
- Page(s)
- Volume
- 8
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Incidence of Postoperative Delirium Is Similar with Regional and General Anesthesia | Rosenberg, K. | Am J Nurs | 2022 |
Aged |
| Delirium and Delirium Severity Predict the Trajectory of the Hierarchical Assessment of Balance and Mobility in Hospitalized Older People: Findings From the DECIDE Study | Richardson, S. Murray, J. Davis, D. Stephan, B. C. M. Robinson, L. Brayne, C. Barnes, L. Parker, S. Sayer, A. A. Dodds, R. M. Allan, L. | J Gerontol A Biol Sci Med Sci | 2022 |
Aged |
| Anesthetic Practice Trends and Perceptions Toward Postoperative Delirium: A Mixed-Methods Analysis | Ragheb, J. Norcott, A. E. Iskander, M. Brooks, J. McKinney, A. Mentz, G. Vlisides, P. E | Anesth Analg | 2022 | |
| Preoperative Vitamin D Deficiency Is Associated With Postoperative Delirium in Critically Ill Patients | Qiu, Y. Sessler, D. I. Chen, L. Halvorson, S. Cohen, B. Bravo, M. Ince, I. Maheshwari, K. Kurz, A. | J Intensive Care Med | 2022 |
Adult |
| Physicians' beliefs and attitudes toward hypoactive delirium in the last days of life | Oya, K. Morita, T. Tagami, K. Matsuda, Y. Naito, A. S. Kashiwagi, H. Otani, H. | J Pain Symptom Manage | 2022 |
antipsychotic |
| Evidence-Based Guideline on Management of Postoperative Delirium in Older People for Low Resource Setting: Systematic Review Article | Mossie, A. Regasa, T. Neme, D. Awoke, Z. Zemedkun, A. Hailu, S. | Int J Gen Med | 2022 |
delirium prevention |
| Delirium diagnosis without a gold standard: Evaluating diagnostic accuracy of combined delirium assessment tools | Moss, S. J. Hee Lee, C. Doig, C. J. Whalen-Browne, L. Stelfox, H. T. Fiest, K. M. | PLoS One | 2022 |
Adult |
| Steroid dosing and delirium after lung transplant surgery | Mody, G. N. Choi, B. Townsend, K. Kerwin, C. Larios, D. Boukedes, S. Coppolino, A. Singh, S. Jin, G. Wolfe, D. Mallidi, H. Goldberg, H. | Gen Hosp Psychiatry | 2022 |
*Delirium/etiology |
| A systematic review of strategies for preventing delirium in patients undergoing vascular surgery | Meulenbroek, A. L. van Mil, S. R. Faes, M. C. Mattace-Raso, F. U. S. Fourneau, I. van der Laan, L. | Ann Vasc Surg | 2022 |
Aneurysm of the abdominal aorta |
| The impact of perioperative stroke and delirium on outcomes after surgical aortic valve replacement | Messé, S. R. Overbey, J. R. Thourani, V. H. Moskowitz, A. J. Gelijns, A. C. Groh, M. A. Mack, M. J. Ailawadi, G. Furie, K. L. Southerland, A. M. James, M. L. Moy, C. S. Gupta, L. Voisine, P. Perrault, L. P. Bowdish, M. E. Gillinov, A. M. O'Gara, P. T. Ou | J Thorac Cardiovasc Surg | 2022 |
aortic valve |
| Tau as a serum biomarker of delirium after major cardiac surgery: a single centre case-control study | McKay, T. B. Qu, J. Liang, F. Mueller, A. Wiener-Kronish, J. Xie, Z. Akeju, O. | Br J Anaesth | 2022 |
Alzheimer’s disease |
| Insulinoma: an uncommon cause of delirium | McComb, K. Roulston, G. Armstrong, L. | Age Ageing | 2022 |
Aged |
| The Twilight Zone: Oxybutynin Overuse Exacerbating Delirium | Marthi, S. Pomerantz, M. A. Mernan, A. J. Berlow, Y. A. | J Geriatr Psychiatry Neurol | 2022 |
anticholinergic medications |
| Corrigendum: Risk Factors for Delirium Are Different in the Very Old: A Comparative One-Year Prospective Cohort Study of 5,831 Patients | Marquetand, J. Bode, L. Fuchs, S. Hildenbrand, F. Ernst, J. von Känel, R. Boettger, S. | Front Psychiatry | 2022 |
comparison |
| The development of the MENTOR_D nursing intervention: Supporting family involvement in delirium management | Mailhot, T. Cossette, S. Lavoie, P. Maheu-Cadotte, M. A. Fontaine, G. Bourbonnais, A. Côté, J. | Int J Older People Nurs | 2022 |
delirium |
| Factors Associated With Severity of Delirium Complicating COVID-19 in Intensive Care Units | Madonna, D. Enrico, P. Ciappolino, V. Boscutti, A. Colombo, E. Turtulici, N. Cantù, F. Cereda, G. Delvecchio, G. De Falco, S. Chierichetti, M. Savioli, M. Grasselli, G. Brambilla, P. | Front Neurol | 2022 |
Ards |
| An open-label clinical trial of oral transmucosal haloperidol and oral transmucosal olanzapine in the treatment of terminal delirium at home | Lyu, X. J. Kan, A. D. Chong, P. H. Lin, K. Koh, Y. H. Yeo, Z. Z. | Trials | 2022 |
*Antipsychotic Agents/adverse effects |
| Family-centred care interventions to reduce the delirium prevalence in critically ill patients: A systematic review and meta-analysis | Lin, L. Peng, Y. Zhang, H. Huang, X. Chen, L. Lin, Y. | Nurs Open | 2022 |
delirium |
| White-Cell Derived Inflammatory Biomarkers in Prediction of Postoperative Delirium in Elderly Patients Undergoing Surgery for Lower Limb Fracture Under Non-General Anaesthesia | Li, X. Wang, G. He, Y. Wang, Z. Zhang, M. | Clin Interv Aging | 2022 |
Aged |
| Comparative salary-related costs of a brief app-directed delirium identification protocol by hospitalists, nurses, and nursing assistants | Leslie, D. L. Fick, D. M. Moore, A. Inouye, S. K. Jung, Y. Ngo, L. H. Boltz, M. Husser, E. Shrestha, P. Boustani, M. Marcantonio, E. R. | J Am Geriatr Soc | 2022 |
cost-analysis |
| Investigation and treatment of asymptomatic bacteriuria in older patients with delirium: a cross-sectional survey of Canadian physicians | Laguë, A. Boucher, V. Joo, P. Yadav, K. Morasse, C. Émond, M. | Cjem | 2022 |
Aged |
| APOE e4 Genotypes Increase Risk of Delirium During COVID-19-Related Hospitalizations: Evidence From a Large UK Cohort | Kuo, C. L. Pilling, L. C. Atkins, J. L. Fortinsky, R. H. Kuchel, G. A. Melzer, D. | J Gerontol A Biol Sci Med Sci | 2022 |
Alleles |
| Nurses' Knowledge about Delirium in the Group of Intensive Care Units Patients | Krupa, S. Friganović, A. Oomen, B. Benko, S. Mędrzycka-Dąbrowska, W. | Int J Environ Res Public Health | 2022 |
Clinical Competence |
| Early Ambulation to Prevent Delirium After Long-Time Head and Neck Cancer Surgery | Kim, J. H. Lee, Y. S. Kim, Y. H. Cho, K. J. Jung, Y. H. Choi, S. H. Nam, S. Y. Kim, S. Y. | Front Surg | 2022 |
ambulation |
| The effect of regional nerve block on perioperative delirium in hip fracture surgery for the elderly: A systematic review and meta-analysis of randomized controlled trials | Kim, C. H. Yang, J. Y. Min, C. H. Shon, H. C. Kim, J. W. Lim, E. J. | Orthop Traumatol Surg Res | 2022 |
Aged |
| Role of multicomponent non-pharmacological nursing interventions on delirium prevention: A randomized controlled study | Kasapoğlu, E. S. Enç, N. | Geriatr Nurs | 2022 |
Critical Illness |
| Early Intervention of Perioperative Delirium in Older Patients (>60 years) with Hip Fracture: A Randomized Controlled Study | Jing, G. W. Xie, Q. Tong, J. Liu, L. Z. Jiang, X. Si, L. | Orthop Surg | 2022 |
Delirium |
| Functional Outcome in Patients with Chronic Subdural Hematoma: Postoperative Delirium and Operative Procedure | Ishida, T. Inoue, T. Inoue, T. Saito, A. Suzuki, S. Uenohara, H. Tominaga, T. | Neurol Med Chir (Tokyo) | 2022 |
*Delirium/etiology |
| Delirium in geriatric patients | Iglseder, B. Frühwald, T. Jagsch, C. | Wien Med Wochenschr | 2022 |
Aged |
| Recognizing Intensive Care Unit Delirium: Are Critical Care Nurses Ready? | Ho, M. H. Chang, H. R. Liu, M. F. Chen, K. H. Shen Hsiao, S. T. Traynor, V. | J Nurs Res | 2022 | |
| Effect of an evidence-based poster on the knowledge of delirium and its prevention in student nurses: A quasi-experimental study | Glass, G. F. Tan, H. Chan, E. Y. | Contemp Nurse | 2022 |
Aged |
| Lack of Association Between Perioperative Medication and Postoperative Delirium in Hip Fracture Patients in an Orthogeriatric Care Pathway | Genet, B. Lamy, T. Cohen-Bittan, J. Glasman, P. Verny, M. Riou, B. Boddaert, J. Zerah, L. | J Am Med Dir Assoc | 2022 |
Aged |
| Dexmedetomidine after Cardiac Surgery for Prevention of Delirium (EXACTUM) trial protocol: a multicentre randomised, double-blind, placebo-controlled trial | Gargadennec, T. Oilleau, J. F. Rozec, B. Nesseler, N. Lasocki, S. Futier, E. Amour, J. Durand, M. Bougle, A. Kerforne, T. Consigny, M. Eddi, D. Huet, O. | BMJ Open | 2022 |
Aged |
| Validation of E-PRE-DELIRIC in cardiac surgical ICU delirium: A retrospective cohort study | Gao, W. Zhang, Y. Jin, J. | Nurs Crit Care | 2022 |
Adult |
| Association Between Sedative Medication Administration and Delirium Development in a Medical Intensive Care Unit | Franz, N. D. Alaniz, C. Miller, J. T. Farina, N. | J Pharm Pract | 2022 |
benzodiazepine |
| Nurse-Driven Assessment, Prevention, and Management of Delirium on an Acute Inpatient Neurology Unit | Francisco, M. A. Gesell, T. Meletis, S. Bohr, N. L. Gleason, L. J. | J Nurs Care Qual | 2022 | |
| Delirium the next frontier | Fong, T. G. Inouye, S. K. | J Gerontol A Biol Sci Med Sci | 2022 |
*Delirium/diagnosis/etiology |
| Presurgical Thalamus Volume in Postoperative Delirium: A Longitudinal Observational Cohort Study in Older Patients | Fislage, M. Feinkohl, I. Pischon, T. Spies, C. D. Borchers, F. Winterer, G. Zacharias, N. | Anesth Analg | 2022 | |
| The association between preoperative Mini-Cog© score and postoperative delirium (POD): a retrospective cohort study | Fiamanya, S. Ma, S. Yates, D. R. A. | Perioper Med (Lond) | 2022 |
Cognitive impairment |
| Delirium severity in critical patients with COVID-19 from an Infectious Disease Intensive Care Unit | Dias, R. Caldas, J. P. Silva-Pinto, A. Costa, A. Sarmento, A. Santos, L. | Int J Infect Dis | 2022 |
*COVID-19/complications |
| Health-Related Quality of Life Following Delirium in the PICU | Dervan, L. A. Killien, E. Y. Smith, M. B. Watson, R. S. | Pediatr Crit Care Med | 2022 |
Aftercare |
| Cuartas, C. F. Davis, M. | Valproic Acid in the Management of Delirium | Am J Hosp Palliat Care | 2022 |
Adult |
| Assessing the Accuracy of International Classification of Diseases (ICD) Coding for Delirium | Chuen, V. L. Chan, A. C. H. Ma, J. Alibhai, S. M. H. Chau, V. | J Appl Gerontol | 2022 |
*Delirium/diagnosis |
| Evaluation of the Impact of Prior-to-Admission Sleep Aid Prescribing Practices on Sleep and Delirium in the Intensive Care Unit | Chudow, M. Paradiso, V. Silva, N. Collette, J. | Ann Pharmacother | 2022 |
Adult |
| Chou, S. T. Pogach, M. Rock, L. K. | Less pharmacotherapy is more in delirium | Intensive Care Med | 2022 | |
| A randomized trial: bispectral-guided anesthesia decreases incidence of delayed neurocognitive recovery and postoperative neurocognitive disorder but not postoperative delirium | Chen, X. Li, L. Yang, L. Li, A. Wu, M. Yu, D. | Am J Transl Res | 2022 |
BIS monitoring |
| Comparative effectiveness of non-pharmacological interventions for preventing delirium in critically ill adults: A systematic review and network meta-analysis | Chen, T. J. Traynor, V. Wang, A. Y. Shih, C. Y. Tu, M. C. Chuang, C. H. Chiu, H. Y. Chang, H. R. | Int J Nurs Stud | 2022 |
Delirium |
| Influence of Renin-Angiotensin System Inhibitors on Postoperative Delirium in Patients With Pulmonary Arterial Hypertension: A Secondary Analysis of a Retrospective Cohort Study | Chen, G. Zhou, S. Deng, F. | Front Psychiatry | 2022 |
ACEIs |
| Delirium in COVID‑19 pneumonia: looking inside the geriatric unit-reply | Callea, A. Conti, G. Caporotundo, S. Della Marca, G. Rollo, E. | Intern Emerg Med | 2022 | |
| Postoperative delirium in the elderly: time to focus on pre- and postoperative management | Bruder, N. | Minerva Anestesiol | 2022 |
Aged |
| Improving ABCDEF Bundle Compliance and Clinical Outcomes in the ICU: Randomized Control Trial to Assess the Impact of Performance Measurement, Feedback, and Data Literacy Training | Brown, J. C. Querubin, J. A. Ding, L. Mack, W. J. Chen-Chan, K. Perez, F. Barr, J. Peden, C. J. Cobb, J. P. | Crit Care Explor | 2022 |
ABCDEF bundle compliance |
| Impact of Cerebral Embolic Protection Devices on the Incidence and Outcomes of Delirium After Transcatheter Aortic Valve Implantation | Bansal, A. Kumar, A. Reed, G. W. Puri, R. Krishnaswamy, A. Linke, A. Yun, J. Kapadia, S. R. | Am J Cardiol | 2022 | |
| Postoperative delirium in older patients after undergoing pelvic organ prolapse surgery | Ackenbom, M. F. Zyczynski, H. M. Butters, M. A. Lopa, S. Orris, S. R. Davis, E. M. | nt Urogynecol J | 2022 |
Cognitive impairment |
| Use of naldemedine is associated with reduced incidence of hyperactive delirium in cancer patients with opioid-induced constipation: a nationwide retrospective cohort study in Japan | Abe, H. Sumitani, M. Matsui, H. Inoue, R. Fushimi, K. Uchida, K. Yasunaga, H. | Pharmacotherapy | 2022 |
delirium |
| Effect of light therapy on delirium in older patients with Alzheimer's disease-related dementia | Zou, C. Mei, X. Li, X. Hu, J. Xu, T. Zheng, C. | J Psychiatr Res | 2022 |
Alzheimer’s disease |
| Association of antipsychotic dose with survival of advanced cancer patients with delirium | Yokomichi, N. Maeda, I. Morita, T. Yoshiuchi, K. Ogawa, A. Hisanaga, T. Sakashita, A. Nakahara, R. Kaneishi, K. Iwase, S. | Ann Palliat Med | 2022 |
Advanced cancer |
| Systematic review and meta-analysis on the incidence of delirium in intensive care unit inpatients after cognitive exercise intervention | Xu, C. Chen, Z. Zhang, L. Guo, H. | Ann Palliat Med | 2022 |
Cognition |
| Electroencephalography in delirium assessment: a scoping review | Wiegand, T. L. T. Rémi, J. Dimitriadis, K. | BMC Neurol | 2022 |
*Delirium/diagnosis/etiology |
| Prophylactic melatonin for delirium in intensive care (Pro-MEDIC): a randomized controlled trial | Wibrow, B. Martinez, F. E. Myers, E. Chapman, A. Litton, E. Ho, K. M. Regli, A. Hawkins, D. Ford, A. van Haren, F. M. P. Wyer, S. McCaffrey, J. Rashid, A. Kelty, E. Murray, K. Anstey, M. | Intensive Care Med | 2022 |
Australia |
| Effect of Electroencephalography Spectral Edge Frequency (SEF) and Patient State Index (PSI)-Guided Propofol-Remifentanil Anesthesia on Delirium After Laparoscopic Surgery: The eMODIPOD Randomized Controlled Trial | Wang, E. Wang, L. Ye, C. Luo, N. Zhang, Y. Zhong, Y. Zhu, M. Zou, Y. Li, Q. Li, L. Song, Z. Luo, H. Dai, F. Liu, H. Gelb, A. W. Guo, Q. Meng, L. | J Neurosurg Anesthesiol | 2022 |
*Anesthesia/adverse effects |
| Hospitalisation costs and Health Related Quality of Life in delirious patients; a scoping review | van Lieshout, C. Schuit, E. Hermes, C. Kerrigan, M. Frederix, G. W. J. | Z Evid Fortbild Qual Gesundhwes | 2022 |
Cost Analysis |
| Rapid cognitive assessment tools for screening of mild cognitive impairment in the preoperative setting: A systematic review and meta-analysis | Tran, J. Nimojan, T. Saripella, A. Tang-Wai, D. F. Butris, N. Kapoor, P. Berezin, L. Englesakis, M. Chung, F. | J Clin Anesth | 2022 |
Cognition |
| Physostigmine for Facilitation of Care in Clozapine-Associated Anticholinergic Delirium | Spring, J. D. Goldstein, B. N. Buster, M. Mahmoud, A. A. Hamm, B. | J Clin Psychopharmacol | 2022 | |
| Relationship between no-visitation policy and the development of delirium in patients admitted to the intensive care unit | Shinohara, F. Unoki, T. Horikawa, M. | PLoS One | 2022 |
Apache |
| USING A REAL-TIME ABCDEF COMPLIANCE TOOL TO UNDERSTAND THE ROLE OF BUNDLE ELEMENTS IN MORTALITY AND DELIRIUM | Shampo, J. C. Wenszell, K. Luo-Owen, X. Mukherjee, N. Cochran-Yu, M. Swentek, L. Burruss, S. K. Markovich, S. Turay, D. Dorotta, I. R. Mukherjee, K. | J Trauma Acute Care Surg | 2022 | |
| Post-discharge Mortality in Patients With Delirium and Dementia: A 3-Year Follow Up Study | Schnorr, T. Fleiner, T. Schroeder, H. Reupke, I. Woringen, F. Trumpf, R. Schroeder, S. Zijlstra, W. Haussermann, P. | Front Psychiatry | 2022 |
aftercare |
| Effects of Physical Exercise on the Incidence of Delirium and Cognitive Function in Acutely Hospitalized Older Adults: A Systematic Review with Meta-Analysis | Sáez de Asteasu, M. L. Cuevas-Lara, C. García-Hermoso, A. Ramírez-Vélez, R. Martínez-Velilla, N. Zambom-Ferraresi, F. Cadore, E. L. Izquierdo, M. | J Alzheimers Dis | 2022 |
Physical exercise |
| Associations Between Stroke Localization and Delirium: A Systematic Review and Meta-Analysis | Rhee, J. Y. Colman, M. A. Mendu, M. Shah, S. J. Fox, M. D. Rost, N. S. Kimchi, E. Y. | J Stroke Cerebrovasc Dis | 2022 |
*Delirium/epidemiology |
| The family in preventing delirium in the intensive care unit: Scoping review | Pabón-Martínez, B. A. Rodríguez-Pulido, L. I. Henao-Castaño, A. M. | Enferm Intensiva (Engl Ed) | 2022 |
Adult |
| The effect of delirium preventive measures on the occurrence of postoperative cognitive dysfunction in older adults undergoing cardiovascular surgery. The DelPOCD randomised controlled trial | Olotu, C. Ascone, L. Wiede, J. Manthey, J. Kuehn, S. Scherwath, A. Kiefmann, R. | J Clin Anesth | 2022 |
Aged |
| Pharmacotherapy for elderly patients with delirium in a general ward setting: A retrospective study | Ohsako, N. Hashimoto, T. Shiko, Y. Kawasaki, Y. Nakagawa, M. Okuma, T. Kurata, T. Suzuki, H. Ishige, M. Kikuchi, S. | Asian J Psychiatr | 2022 |
Aged |
| Regional cerebral hypometabolism on 18F-FDG PET/CT scan in delirium is independent of acute illness and dementia | Nitchingham, A. Pereira, J. V. Wegner, E. A. Oxenham, V. Close, J. Caplan, G. A. | Alzheimers Dement | 2022 |
18F-fluorodeoxyglucose positron emission tomography |
| Delirium screening with 4AT in patients aged 65 years and older admitted to the Emergency Department with suspected sepsis: a prospective cohort study | Myrstad, M. Kuwelker, K. Haakonsen, S. Valebjørg, T. Langeland, N. Kittang, B. R. Hagberg, G. Neerland, B. E. Bakken, M. S. | Eur Geriatr Med | 2022 |
Aged |
| The DEMS-DOSS study: validating a delirium monitoring tool in hospitalised older adults | Montgomery, A. Todd, J. A. Jones, C. Koroitamana, J. Grealish, L. Wand, A. Billett, S. Teodorczuk, A. | Age Ageing | 2022 |
Aged |
| Effectiveness of Interprofessional Consultation-Based Interventions for Delirium: A Scoping Review | Monaghan, C. Martin, G. Kerr, J. Peters, M. L. Versloot, J. | J Appl Gerontol | 2022 |
Accidental Falls/prevention & control |
| PRe-Operative Prediction of postoperative DElirium by appropriate SCreening (PROPDESC) development and validation of a pragmatic POD risk screening score based on routine preoperative data | Menzenbach, J. Kirfel, A. Guttenthaler, V. Feggeler, J. Hilbert, T. Ricchiuto, A. Staerk, C. Mayr, A. Coburn, M. Wittmann, M. | J Clin Anesth | 2022 |
*Delirium/diagnosis/epidemiology/etiology |
| Behavioral Variant Frontotemporal Dementia and Social and Criminal Transgressions | Mendez, M. F. | J Neuropsychiatry Clin Neurosci | 2022 |
Cognition |
| Effects of Abdominal Wall Blocks on Postoperative Delirium in Elderly Patients Undergoing Laparoscopic Surgery: A Randomized Controlled Study | Liu, T. Tuo, J. Wei, Q. Sun, X. Zhao, H. Zhao, X. Qu, M. | Med Sci Monit | 2022 |
Aged |
| Preoperative Status of Gut Microbiota Predicts Postoperative Delirium in Patients With Gastric Cancer | Liu, H. Cheng, G. Xu, Y. L. Fang, Q. Ye, L. Wang, C. H. Liu, X. S. | Front Psychiatry | 2022 |
Shigella |
| Nurses' experiences in the management of delirium among older persons in acute care ward settings: A qualitative systematic review and meta-aggregation | Lim, X. M. Lim, Z. H. T. Ignacio, J. | Int J Nurs Stud | 2022 |
Aged |
| Predicting hospital mortality and length of stay: A prospective cohort study comparing the Intensive Care Delirium Screening Checklist versus Confusion Assessment Method for the Intensive Care Unit | Li, H. C. Chen, C. C. Yeh, T. Y. Liao, S. C. Hsu, A. S. Wei, Y. C. Shun, S. C. Ku, S. C. Inouye, S. K. | Aust Crit Care | 2022 |
CAM-ICU (Confusion Assessment Method for Intensive Care Unit) |
| Can we improve delirium prevention and treatment in the emergency department? A systematic review | Lee, S. Chen, H. Hibino, S. Miller, D. Healy, H. Lee, J. S. Arendts, G. Han, J. H. Kennedy, M. Carpenter, C. R. | J Am Geriatr Soc | 2022 |
delirium |
| Prevalence, management and outcomes of unrecognized delirium in a National Sample of 1,493 older emergency department patients: how many were sent home and what happened to them? | Lee, J. S. Tong, T. Chignell, M. Tierney, M. C. Goldstein, J. Eagles, D. Perry, J. J. McRae, A. Lang, E. Hefferon, D. Rose, L. Kiss, A. Borgundvaag, B. McLeod, S. Melady, D. Boucher, V. Sirois, M. J. Émond, M. | Age Aging | 2022 |
*Aftercare |
| COVID-19 severity and age increase the odds of delirium in hospitalized adults with confirmed SARS-CoV-2 infection: a cohort study | LaHue, S. C. Escueta, D. P. Guterman, E. L. Patel, K. Harrison, K. L. Boscardin, W. J. Douglas, V. C. Newman, J. C. | BMC Psychiatry | 2022 |
Adult |
| Outcomes in heart failure patients discharged to skilled nursing facilities with delirium | Lafo, J. Singh, M. Jiang, L. Correia, S. Madrigal, C. Clements, R. Wu, W. C. Erqou, S. Rudolph, J. L. | ESC Heart Fail | 2022 |
Delirium |
| Distribution of delirium motor subtypes in the intensive care unit: a systematic scoping review | la Cour, K. N. Andersen-Ranberg, N. C. Weihe, S. Poulsen, L. M. Mortensen, C. B. Kjer, C. K. W. Collet, M. O. Estrup, S. Mathiesen, O. | Crit Care | 2022 |
Aged |
| Factors associated with post-operative delirium in hip fracture patients: what should we care | Kong, D. Luo, W. Zhu, Z. Sun, S. Zhu, J. | Eur J Med Res | 2022 |
Aged |
| Factors Associated With Postoperative Delirium in Patients Undergoing Complex Head and Neck Flap Surgery | Kolk, A. Schwarzer, C. Wolff, K. D. Grill, F. Weingart, J. | J Oral Maxillofac Surg | 2022 |
Adolescent |
| Increased postoperative myeloperoxidase concentration associated with low baseline antioxidant capacity as the risk factor of delirium after cardiac surgery | Kaźmierski, J. Miler, P. Pawlak, A. Jerczyńska, H. Nowakowska, K. Walkiewicz, G. Woźniak, K. Krejca, M. Wilczyński, M. | Ann Med | 2022 |
Antioxidants |
| Could neutrophil-to-lymphocyte ratio predict mortality in community-dwelling older people with delirium superimposed on dementia? | Katipoglu, B. Naharci, M. I. | Aging Clin Exp Res | 2022 |
Delirium |
| The efficacy and safety of nurse-initiated sedation management in an intensive care unit: A two-phase prospective study in Japan | Kanda, N. Nakano, H. Naraba, H. Kawasaki, A. Ohno, N. Yoshikawa, Y. Sakuramoto, H. Takahashi, Y. Sonoo, T. Hashimoto, H. Nakamura, K. | Jpn J Nurs Sci | 2022 |
Richmond Agitation-Sedation Scale |
| Albumin/fibrinogen ratio, an independent risk factor for postoperative delirium after total joint arthroplasty | Jiang, L. Lei, G. | Geriatr Gerontol Int | 2022 |
albumin/fibrinogen ratio |
| Association of preoperative vitamin D deficiency with the risk of postoperative delirium and cognitive dysfunction: A meta-analysis | Hung, K. C. Wang, L. K. Lin, Y. T. Yu, C. H. Chang, C. Y. Sun, C. K. Chen, J. Y. | J Clin Anesth | 2022 |
Postoperative cognitive dysfunction |
| Sailing in a sea of perplexity: Family caregivers' experience of patients with delirium | Huang, L. J. Tsai, H. H. Wang, Y. W. Chou, C. L. | Nurs Crit Care | 2022 |
*Caregivers |
| Association Between Hypernatremia and Delirium After Cardiac Surgery: A Nested Case-Control Study | Hong, L. Shen, X. Shi, Q. Song, X. Chen, L. Chen, W. Chen, S. Xue, Y. Zhang, C. Zhou, J. | Front Cardiovasc Med | 2022 |
cardiac surgery |
| Harmonization of Four Delirium Instruments: Creating Crosswalks and the Delirium Item-Bank (DEL-IB) | Helfand, B. K. I. Detroyer, E. Milisen, K. Adamis, D. Metzger, E. D. Boudreaux, E. D. Inouye, S. K. Jones, R. N. | Am J Geriatr Psychiatry | 2022 |
Aged |
| Does delirium prevention reduce risk of in-patient falls among older adults? A systematic review and trial sequential meta-analysis | He, S. Rolls, K. Stott, K. Shekhar, R. Vueti, V. Flowers, K. Moseley, M. Shepherd, B. Mayahi-Neysi, M. Chasle, B. Warner, B. Ni Chroinin, D. Frost, S. A. | Australas J Ageing | 2022 |
accidental falls |
| Detection of delirium by family members in the intensive care unit: Translation, Cross-Cultural adaptation and validation of the Family Confusion Assessment Method for the German-Speaking area | Greindl, S. Weiss, B. Magnolini, R. Lingg, C. Mayer, H. Schaller, S. J. | J Adv Nurs | 2022 |
Family Confusion Assessment Method |
| Patient-related risk factors for in-hospital functional decline in older adults: A systematic review and meta-analysis | Geyskens, L. Jeuris, A. Deschodt, M. Van Grootven, B. Gielen, E. Flamaing, J. | Age Ageing | 2022 |
*Activities of Daily Living |
| Screening for delirium and dementia in older hospitalised adults in Zambia | George, G. Fricker, M. Todd, O. Makowa, D. Tembo, C. Dotchin, C. Gray, W. K. Walker, R. W. Mbwele, B. Paddick, S. M. | J Neurol Sci | 2022 |
Delirium |