What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients (Review)
- Authors
- Burton JK, Craig LE, Yong SQ, Siddiqi N, Teale EA, Woodhouse R, Barugh AJ, Shepherd AM, Brunton A, Freeman SC, Sutton AJ, Quinn TJ
- Year
- 2021
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is an acute neuropsychological disorder that is common in hospitalised patients. It can be distressing to patients and carers and it is associated with serious adverse outcomes. Treatment options for established delirium are limited and so prevention of delirium is desirable. Non-pharmacological interventions are thought to be important in delirium prevention. OBJECTIVES: To assess the effectiveness of non-pharmacological interventions designed to prevent delirium in hospitalised patients outside intensive care units (ICU).
Search methods: We searched ALOIS, the specialised register of the Cochrane Dementia and Cognitive Improvement Group, with additional searches conducted in MEDLINE, Embase, PsycINFO, CINAHL, LILACS, Web of Science Core Collection, ClinicalTrials.gov and the World Health Organization Portal/ICTRP to 16 September 2020. There were no language or date restrictions applied to the electronic searches, and no methodological filters were used to restrict the search.
Selection criteria: We included randomised controlled trials (RCTs) of single and multicomponent non-pharmacological interventions for preventing delirium in hospitalised adults cared for outside intensive care or high dependency settings. We only included non-pharmacological interventions which were designed and implemented to prevent delirium. DATA COLLECTION AND ANALYSIS: Two review authors independently examined titles and abstracts identified by the search for eligibility and extracted data from full-text articles. Any disagreements on eligibility and inclusion were resolved by consensus. We used standard Cochrane methodological procedures. The primary outcomes were: incidence of delirium; inpatient and later mortality; and new diagnosis of dementia. We included secondary and adverse outcomes as pre-specified in the review protocol. We used risk ratios (RRs) as measures of treatment effect for dichotomous outcomes and between-group mean differences for continuous outcomes. The certainty of the evidence was assessed using GRADE. A complementary exploratory analysis was undertaker using a Bayesian component network meta-analysis fixed-effect model to evaluate the comparative effectiveness of the individual components of multicomponent interventions and describe which components were most strongly associated with reducing the incidence of delirium.
Main results: We included 22 RCTs that recruited a total of 5718 adult participants. Fourteen trials compared a multicomponent delirium prevention intervention with usual care. Two trials compared liberal and restrictive blood transfusion thresholds. The remaining six trials each investigated a different non-pharmacological intervention. Incidence of delirium was reported in all studies. Using the Cochrane risk of bias tool, we identified risks of bias in all included trials. All were at high risk of performance bias as participants and personnel were not blinded to the interventions. Nine trials were at high risk of detection bias due to lack of blinding of outcome assessors and three more were at unclear risk in this domain. Pooled data showed that multi-component non-pharmacological interventions probably reduce the incidence of delirium compared to usual care (10.5% incidence in the intervention group, compared to 18.4% in the control group, risk ratio (RR) 0.57, 95% confidence interval (CI) 0.46 to 0.71, I2 = 39%; 14 studies; 3693 participants; moderate-certainty evidence, downgraded due to risk of bias). There may be little or no effect of multicomponent interventions on inpatient mortality compared to usual care (5.2% in the intervention group, compared to 4.5% in the control group, RR 1.17, 95% CI 0.79 to 1.74, I2 = 15%; 10 studies; 2640 participants; low-certainty evidence downgraded due to inconsistency and imprecision). No studies of multicomponent interventions reported data on new diagnoses of dementia. Multicomponent interventions may result in a small reduction of around a day in the duration of a delirium episode (mean difference (MD) -0.93, 95% CI -2.01 to 0.14 days, I2 = 65%; 351 participants; low-certainty evidence downgraded due to risk of bias and imprecision). The evidence is very uncertain about the effect of multicomponent interventions on delirium severity (standardised mean difference (SMD) -0.49, 95% CI -1.13 to 0.14, I2=64%; 147 participants; very low-certainty evidence downgraded due to risk of bias and serious imprecision). Multicomponent interventions may result in a reduction in hospital length of stay compared to usual care (MD -1.30 days, 95% CI -2.56 to -0.04 days, I2=91%; 3351 participants; low-certainty evidence downgraded due to risk of bias and inconsistency), but little to no difference in new care home admission at the time of hospital discharge (RR 0.77, 95% CI 0.55 to 1.07; 536 participants; low-certainty evidence downgraded due to risk of bias and imprecision). Reporting of other adverse outcomes was limited. Our exploratory component network meta-analysis found that re-orientation (including use of familiar objects), cognitive stimulation and sleep hygiene were associated with reduced risk of incident delirium. Attention to nutrition and hydration, oxygenation, medication review, assessment of mood and bowel and bladder care were probably associated with a reduction in incident delirium but estimates included the possibility of no benefit or harm. Reducing sensory deprivation, identification of infection, mobilisation and pain control all had summary estimates that suggested potential increases in delirium incidence, but the uncertainty in the estimates was substantial. Evidence from two trials suggests that use of a liberal transfusion threshold over a restrictive transfusion threshold probably results in little to no difference in incident delirium (RR 0.92, 95% CI 0.62 to 1.36; I2 = 9%; 294 participants; moderate-certainty evidence downgraded due to risk of bias). Six other interventions were examined, but evidence for each was limited to single studies and we identified no evidence of delirium prevention. AUTHORS’ CONCLUSIONS: There is moderate-certainty evidence regarding the benefit of multicomponent non-pharmacological interventions for the prevention of delirium in hospitalised adults, estimated to reduce incidence by 43% compared to usual care. We found no evidence of an effect on mortality. There is emerging evidence that these interventions may reduce hospital length of stay, with a trend towards reduced delirium duration, although the effect on delirium severity remains uncertain. Further research should focus on implementation and detailed analysis of the components of the interventions to support more effective, tailored practice recommendations.
- PMID
- Keywords
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Correlation and influencing factors of preoperative anxiety, postoperative pain, and delirium in elderly patients undergoing gastrointestinal cancer surgery | Liu, Q. Li, L. Wei, J. Xie, Y. | BMC Anesthesiol | 2023 |
Aged, Humans, *Emergence Delirium/epidemiology, Postoperative, Complications/epidemiology/etiology, *Delirium/etiology/complications, Pain,, Postoperative/epidemiology/complications, Anxiety/epidemiology, Risk Factors, *Gastrointestinal Neoplasms/complications/surgery, Anxiety, Delirium, Elderly, Gastrointestinal cancer, Pain |
| Postoperative delirium and its influencing factors in elderly patients with lung cancer in the intensive care unit | Lu, Y. Liu, X. | J Thorac Dis | 2023 |
Lung cancer, elderly patients, factors, intensive care unit (ICU), postoperative delirium (POD) |
| Dexmedetomidine for the prevention of delirium in adults admitted to the intensive care unit or post-operative care unit: A systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis | Maagaard, M. Barbateskovic, M. Andersen-Ranberg, N. C. Kronborg, J. R. Chen, Y. X. Xi, H. H. Perner, A. Wetterslev, J. | Acta Anaesthesiol Scand | 2023 |
Adult, Humans, Critical Care, *Delirium/prevention & control, *Dexmedetomidine/therapeutic use, Hospitalization, Intensive Care Units, delirium, dexmedetomidine, intensive care unit, meta-analysis, post-operative, systematic review |
| Delirium: Prevalence and outcome in the very old in 27 medical departments during a one-year prospective study | Marquetand, J. Bode, L. Fuchs, S. Ernst, J. von Känel, R. Boettger, S. | Palliat Support Care | 2022 |
Humans, Prospective Studies, Prevalence, *Delirium/diagnosis, Critical Care, Nursing Homes, Intensive Care Units, Risk Factors, Consultation, Death, Loss of independence, Psychiatric, Risk, Services |
| Pharmacological prevention of postoperative delirium in patients undergoing cardiac surgery: a bayesian network meta-analysis | Meco, M. Giustiniano, E. Cecconi, M. Albano, G. | J Anesth | 2023 |
Humans, *Emergence Delirium/prevention & control/complications, Network, Meta-Analysis, Bayes Theorem, *Delirium/etiology/prevention & control/epidemiology, *Cardiac Surgical Procedures/adverse effects, Postoperative Complications/epidemiology, Cardiac surgery, Pharmacological prevention, Postoperative delirium, Randomized controlled trials meta-analysis |
| Development and validation of a delirium risk prediction model using a modified version of the Delirium Elderly at Risk (mDEAR) screen in hospitalized patients aged 65 and older: A medical record review | Meehan, A. J. Gabra, J. N. Distelhorst, K. S. Whyde, C. Mangira, C. | Acta Psychiatr Scand | 2023 |
Delirium, Delirium risk prediction older adults, Nursing delirium admission screen, aged, screening |
| Evaluating the performance of machine learning methods for risk estimation of delirium in patients hospitalized from the emergency department | Mueller, B. Street, W. N. Carnahan, R. M. Lee, S. | Acta Psychiatr Scand | 2023 |
delirium, emergency department, risk estimation, health record review, machine learning |
| Relationship between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers prescribing and delirium in the ICU-A secondary analysis | Mulkey, M. A. Khan, S. Perkins, A. Gao, S. Wang, S. Campbell, N. Khan, B. | J Am Geriatr Soc | 2023 |
ACE inhibitor, angiotensin receptor blocker, critical care, delirium, intensive care |
| Bispectral EEG (BSEEG) Algorithm Captures High Mortality Risk Among 1,077 Patients: Its Relationship to Delirium Motor Subtype | Nishizawa, Y. Yamanashi, T. Saito, T. Marra, P. Crutchley, K. J. Wahba, N. E. Malicoat, J. Shibata, K. Nishiguchi, T. Lee, S. Cho, H. R. Kanazawa, T. Shinozaki, G. | Am J Geriatra Psychiatry | 2023 |
Bseeg, Bispectral electroencephalogram, delirium, mortality, motor subtype |
| Computable Phenotypes to Characterize Changing Patient Brain Dysfunction in the Intensive Care Unit | Ren, Y. Loftus, T. J. Guan, Z. Uddin, R. Shickel, B. Maciel, C. B. Busl, K. Rashidi, P. Bihorac, A. Ozrazgat-Baslanti, T. | ArXiv | 2023 |
Acute brain dysfunction, delirium, Intensive Care Unit, automated computable phenotypes, algorithm |
| Association between obstructive sleep apnea and atrial fibrillation and delirium after cardiac surgery. Sub-analysis of DECADE trial | Rivas, E. Shehata, P. Bravo, M. Almonacid-Cardenas, F. Shah, K. Kopac, O. Ruetzler, K. Troianos, C. A. Turan, A. | J Clin Anesth | 2023 |
Atrial fibrillation, Cardiac surgery, Delirium, Obstructive sleep apnea, Intensive Care Unit |
| Spinal Dexamethasone Effect on Cognitive Disorders After Hip Surgery | Sakic, L. Tonkovicc, D. Hrgovic, Z. Klasan, A. | Med Arch | 2023 |
Humans, Aged, Levobupivacaine, Hydrocortisone, *Cognition Disorders, *Cognitive Dysfunction, Dexamethasone/therapeutic use, delirium, dexamethasone, proximal femoral fracture, spinal anesthesia |
| Effects of Melatonin Administration on Post-Stroke Delirium in Patients with Intracerebral Hemorrhage | Siokas, V. Roesch, S. Stefanou, M. I. Buesink, R. Wilke, V. Sartor-Pfeiffer, J. Adeyemi, K. Poli, S. Dardiotis, E. Ziemann, U. Feil, K. Mengel, A. | J Clin Med | 2023 |
intracerebral hemorrhage, melatonin, post-stroke delirium, prospective study, stroke unit |
| Clinical Risk Group as a predictor of mortality in delirious older adults in the emergency department | Soler-Sanchis, A. Martínez-Arnau, F. M. Sánchez-Frutos, J. Pérez-Ros, P. | Exp Gerontol | 2023 |
Male, Humans, Aged, Aged, 80 and over, Female, Prospective Studies, *Delirium/diagnosis/complications, Hospitalization, Risk Factors, Emergency Service, Hospital, Chronicity, Delirium, Emergency department, Survival |
| Plasma biomarkers and delirium in critically ill patients after cardiac surgery: A prospective observational cohort study | Su, L. J. Chen, M. J. Yang, R. Zou, H. Chen, T. T. Li, S. L. Guo, Y. Hu, R. F. | Heart Lung | 2023 |
Humans, Middle Aged, Prospective Studies, Tumor Necrosis Factor-alpha, Interleukin-6, *Delirium/diagnosis/etiology, Critical Illness, Biomarkers, Intensive Care Units, *Cardiac Surgical Procedures/adverse effects, Cardiac surgery, Delirium, Intensive care unit |
| Safety of baclofen versus tizanidine for older adults with musculoskeletal pain | Su Zhang, V. R. Niu, F. Lee, E. A. DiStasio, C. Broder, B. I. Steinberg, S. G. Hui, R. L. | J Am Geriatr Soc | 2023 |
baclofen, delirium, injury, safety, tizanidine |
| Delirium Risk Score in Elderly Patients with Cervical Spinal Cord Injury and/or Cervical Fracture | Tanner, M.Tamai, K. Terai, H. Nakamura, H. Yokogawa, N. Sasagawa, T. Nakashima, H. Segi, N. Ito, S. Funayama, T. Eto, F. Yamaji, A. Watanabe, K. Yamane, J. Takeda, K. Furuya, T. Yunde, A. Nakajima, H. Yamada, T. Hasegawa, T. Terashima, Y. Hirota, R. Suzuk | J Clin Med | 2023 |
cervical fracture, cervical spinal cord injury, delirium, elderly, prediction |
| Persistent delirium in older hospital patients: an updated systematic review and meta-analysis | Whitby, J. Nitchingham, A. Caplan, G. Davis, D. Tsui, A. | PLoS One | 2022 |
Humans, Aged, *Delirium/etiology, Inpatients, *Cognition Disorders/complications, *Cognitive Dysfunction/complications, Risk Factors, Geriatric Assessment |
| Delirium in older hospitalized patients-A prospective analysis of the detailed course of delirium in geriatric inpatients | Wilke, S. Steiger, E. Bärwolff, T. L. Kleine, J. F. Müller-Werdan, U. Rosada, A. | PLoS One | 2023 |
Humans, Aged, *Delirium/etiology, Inpatients, *Cognition Disorders/complications, *Cognitive Dysfunction/complications, Risk Factors, Geriatric Assessment |
| Anti-inflammatory medication use associated with reduced delirium risk and all-cause mortality: A retrospective cohort study | Yamanashi, T. Sullivan, E. J. Comp, K. R. Nishizawa, Y. Akers, C. C. Chang, G. Modukuri, M. Tran, T. Anderson, Z. E. M. Marra, P. S. Crutchley, K. J. Wahba, N. E. Iwata, M. Karam, M. D. Noiseux, N. O. Cho, H. R. Shinozaki, G. | J Psychosom Res | 2023 |
Anti-inflammatory medication, Delirium, Glucosamine, Mortality, NSAIDs |
| Application of a flexible visitation system in critically ill patients: A randomized clinical trial | Yang, H. Y. Feng, F. Yang, W. W. Chen, Y. | Sci Prog | 2023 |
Humans, Critical Illness/therapy, *Delirium, Intensive Care Units, Length of Stay, *Cross Infection, ChiCTR2200059093, Flexible visitation system, Trial registration: ChiCTR, delirium, high-quality care |
| Association between preoperative anxiety and postoperative delirium in older patients: a systematic review and meta-analysis | Yang, K. L. Detroyer, E. Van Grootven, B. Tuand, K. Zhao, D. N. Rex, S. Milisen, K. | BMC Geriatr | 2023 |
Humans, Aged, 80 and over, *Emergence Delirium, *Delirium/diagnosis/epidemiology/etiology, Prospective Studies, Anxiety/diagnosis, Postoperative, Complications/diagnosis/epidemiology/etiology, Risk Factors |
| Ramelteon for delirium prevention in hospitalized patients: An updated meta-analysis and trial sequential analysis of randomized controlled trials | Yu, C. L. Carvalho, A. F. Thompson, T. Tsai, T. C. Tseng, P. T. Tu, Y. K. Yang, S. N. Yang, F. C. Chang, C. H. Hsu, C. W. Hsu, T. W. Liang, C. S. | J Pineal Res | 2023 |
Humans, Middle Aged, *Delirium/prevention & control/drug therapy/epidemiology, *Melatonin/therapeutic use, Randomized Controlled Trials as Topic, Reproducibility of Results, delirium prevention, hospitalized patients, meta-analysis, ramelteon, trial sequential analysis |
| A large-scale causal analysis of gut microbiota and delirium: A Mendelian randomization study | Yu, H. Wan, X. Yang, M. Xie, J. Xu, K. Wang, J. Wang, G. Xu, P. | J Affect Disord | 2023 |
Humans, *Gastrointestinal Microbiome/genetics, Mendelian Randomization, Analysis, Causality, *Delirium/epidemiology/genetics, Genome-Wide Association Study, Causal correlation, Delirium, Gut microbiota, Large scale analysis, Mendelian randomization |
| Effectiveness of dexmedetomidine on postoperative cognitive dysfunction in elderly patients with fracture: A systematic review | Zeng, T., Lv, J., Cui, Y., Li, X., F. Zhang, Q. | Medicine (Baltimore) | 2023 |
Aged, Humans, Cognition, *Cognitive Dysfunction/etiology,, *Delirium/epidemiology/etiology, *Dexmedetomidine/adverse effects, *Postoperative Cognitive Complications, Postoperative, Complications/epidemiology, Randomized Controlled Trials as Topic |
| Pharmacologic Interventions to Prevent Delirium in Trauma Patients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials | Zitikyte, G. Roy, D. C. Tran, A. Fernando, S. M. Rosenberg, E. Kanji, S. Engels, P. T. Wells, G. A. & Vaillancourt, C. | Crit Care Explor | 2023 |
critical care, delirium, dexmedetomidine, propofol, systematic review, trauma, interest |
| A novel predictive model for postoperative delirium using multiple geriatric screening factors | Yajima, S. Nakanishi, Y. Sugimoto, M. Kobayashi, S. Kudo, M. Yasujima, R. Hirose, K. Sekiya, K. Umino, Y. Okubo, N. Kataoka, M. Gotohda, N. Masuda, H. | J Surg Oncol | 2023 |
Mini-Cog |
| The Effect of Consultation-Liaison Psychiatry on Postoperative Delirium in Elderly Hip Fracture Patients in the General Hospital | Xie, Q. Liu, X. B. Jing, G. W. Jiang, X. Liu, H. Zhong, B. L. Li, Y. | Orthop Surg | 2023 |
Humans |
| Quantitative EEG signatures of delirium and coma in mechanically ventilated ICU patients | Williams Roberson, S. Azeez, N. A. Fulton, J. N. Zhang, K. C. Lee, A. X. T. Ye, F. Pandharipande, P. Brummel, N. E. Patel, M. B. Ely, E. W. | Clin Neurophysiol | 2023 |
Humans |
| Delirium in trauma ICUs: a review of incidence, risk factors, outcomes, and management | Williams, E. C. Estime, S. Kuza, C. M. | Curr Opin Anaesthesiol | 2023 | |
| Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients | Watne, L. O. Pollmann, C. T. Neerland, B. E. Quist-Paulsen, E. Halaas, N. B. Idland, A. V. Hassel, B. Henjum, K. Knapskog, A. B. Frihagen, F. Raeder, J. Godø, A. Ueland, P. M. McCann, A. Figved, W. Selbæk, G. Zetterberg, H. Fang, E. F. Myrstad, M. Giil, | J Clin Invest | 2023 |
Humans |
| Effect of perioperative benzodiazepine use on intraoperative awareness and postoperative delirium: a systematic review and meta-analysis of randomised controlled trials and observational studies | Wang, E. Belley-Côté, E. P. Young, J. He, H. Saud, H. D'Aragon, F. Um, K. Alhazzani, W. Piticaru, J. Hedden, M. Whitlock, R. Mazer, C. D. Kashani, H. H. Zhang, S. Y. Lucas, A. Timmerman, N. Nishi, C. Jain, D. Kugler, A. Beaver, C. Kloppenburg, S. Schulm | Br J Anaesth | 2023 |
benzodiazepines |
| Sustained adherence to a delirium guideline five years after implementation in an intensive care setting: A retrospective cohort study | van Bochove-Waardenburg, M. van der Jagt, M. de Man-van Ginkel, J. Ista, E. | Intensive Crit Care Nurs | 2023 |
Adherence |
| A survey of current practices in sedation, analgesia, withdrawal, and delirium management in paediatric cardiac ICUs | Valentine, K. Cisco, M. J. Lasa, J. J. Achuff, B. J. Kudchadkar, S. R. Staveski, S. L. | Cardiol Young | 2023 |
Delirium |
| Understanding the association between admission source and in-hospital delirium: A cross-sectional study | Thomas, M. K. Heincelman, M. E. Zhang, J. Marsden, J. Dulin, J. Robbins, P. Hunt, K. Mauldin, P. Moran, W. P. Kalivas, B. | J Investig Med | 2023 |
Adult |
| Sevoflurane dose and postoperative delirium: a prospective cohort analysis | Taylor, J. Payne, T. Casey, C. Kunkel, D. Parker, M. Rivera, C. Zetterberg, H. Blennow, K. Pearce, R. A. Lennertz, R. C. McCulloch, T. Gaskell, A. Sanders, R. D. | Br J Anaesth | 2023 |
Humans |
| Efficacy of transcranial direct current stimulation on postoperative delirium in elderly patients undergoing lower limb major arthroplasty: A randomized controlled trial | Tao, M. Zhang, S. Han, Y. Li, C. Wei, Q. Chen, D. Zhao, Q. Yang, J. Liu, R. Fang, J. Li, X. Zhang, H. Liu, H. Cao, J. L. | Brain Stimul | 2023 |
Lower limb major arthroplasty |
| Medical and economic burden of delirium on hospitalization outcomes of acute respiratory failure: A retrospective national cohort | Taha, A. Xu, H. Ahmed, R. Karim, A. Meunier, J. Paul, A. Jawad, A. Patel, M. L. | Medicine (Baltimore) | 2023 |
Humans |
| Poor prognostic impact of delirium: especially on mortality and institutionalisation | Tachibana, M. Inada, T. | Psychogeriatrics | 2023 |
Humans |
| Processed electroencephalography-guided general anaesthesia to reduce postoperative delirium: a systematic review and meta-analysis | Sumner, M. Deng, C. Evered, L. Frampton, C. Leslie, K. Short, T. Campbell, D. | Br J Anaesth | 2023 |
Humans |
| Expanding options to include language barriers for predicting postoperative delirium in geriatric patients | Streetman, D. Hagley, A. Shalom, M. Gendreau, J. L. | J Am Geriatr Soc | 2023 |
Humans |
| Comparison of logistic regression and machine learning methods for predicting postoperative delirium in elderly patients: A retrospective study | Song, Y. X. Yang, X. D. Luo, Y. G. Ouyang, C. L. Yu, Y. Ma, Y. L. Li, H. Lou, J. S. Liu, Y. H. Chen, Y. Q. Cao, J. B. Mi, W. D. | CNS Neurosci Ther | 2023 |
Humans |
| Effects of anti-ulcer drugs on delirium in trauma patients | Sogawa, R. Matsuoka, A. Murakawa-Hirachi, T. Kikkawa, N. Kamo, M. Tobita, S. Shinada, K. Mizoguchi, Y. Monji, A. Sakamoto, Y. Shimanoe, C. | Gen Hosp Psychiatry | 2023 |
Humans |
| Delirium superimposed on dementia in post-acute care: Nurse documentation of symptoms and interventions | Sillner, A. Y. Berish, D. Mailhot, T. Sweeder, L. Fick, D. M. Kolanowski, A. M. | Geriatr Nurs | 2023 |
Humans |
| Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia: A Randomized Controlled Trial | Shin, H. J. Woo Nam, S. Kim, H. Yim, S. Han, S. H. Hwang, J. W. Do, S. H. Na, H. S. | Anesthesiology | 2023 |
Humans |
| Preoperative characterization of baseline EEG recordings for risk stratification of post-anesthesia care unit delirium | Schüßler, J. Ostertag, J. Georgii, M. T. Fleischmann, A. Schneider, G. Pilge, S. Kreuzer, M. | J Clin Anesth | 2023 |
Anesthesia |
| Certified Nursing Assistants' Perspectives on Delirium Care | Sabbe, K. Aerts, N. van der Mast, R. Van Rompaey, B. | J Gerontol Nurs | 2023 |
Humans |
| Neurophysiologic predictors of individual risk for post-operative delirium after elective surgery | Ross, J. M. Santarnecchi, E. Lian, S. J. Fong, T. G. Touroutoglou, A. Cavallari, M. Travison, T. G. Marcantonio, E. R. Libermann, T. A. Schmitt, E. M. Inouye, S. K. Shafi, M. M. Pascual-Leone, A. | J Am Geriatr Soc | 2023 |
Humans |
| Nighttime dexmedetomidine for delirium prevention in non-mechanically ventilated patients after cardiac surgery (MINDDS): A single-centre, parallel-arm, randomised, placebo-controlled superiority trial | Qu, J. Z. Mueller, A. McKay, T. B. Westover, M. B. Shelton, K. T. Shaefi, S. D'Alessandro, D. A. Berra, L. Brown, E. N. Houle, T. T. Akeju, O. | EClinicalMedicine | 2023 |
Cardiac surgery |
| Effect of seasons on delirium in postoperative critically ill patients: a retrospective analysis | Qiu, Y. Rivas, E. Tanios, M. Sreedharan, R. Mao, G. Ince, I. Salih, A. Saab, R. Devarajan, J. Ruetzler, K. Turan, A. | Braz J Anesthesiol | 2023 |
Adult |
| Transcutaneous electrical acupoint stimulation combined with an integrated perioperative nursing program prevents subsyndromal delirium in older patients after joint replacement | Qian, J. He, M. Zhan, X. Ren, L. Sun, Q. | Geriatr Nurs | 2023 |
Humans |
| Web-Based Delirium Prevention Application for Long-Term Care Facilities | Park, M. Moon, K. J. | J Am Med Dir Assoc | 2023 |
Delirium |
| The effect of all-cause hospitalization on cognitive decline in older adults: a longitudinal study using databases of the National Health Insurance Service and the memory clinics of a self-run hospital | Park, D. Kim, H. S. Kim, J. H. | BMC Geriatr | 2023 |
Humans |
| Investigating nurses' knowledge and attitudes about delirium in older persons: a cross-sectional study | Papaioannou, M. Papastavrou, E. Kouta, C. Tsangari, H. Merkouris, A. | BMC Nurs | 2023 |
Acute confusion |
| Risk factors and consequences of post-esophagectomy delirium: a systematic review and meta-analysis | Papaconstantinou, D. Frountzas, M. Ruurda, J. P. Mantziari, S. Tsilimigras, D. I. Koliakos, N. Tsivgoulis, G. Schizas, D. | Dis Esophagus | 2023 |
anastomotic leakage |
| Natural Language Processing CAM Algorithm Improves Delirium Detection Compared With Conventional Methods | Pagali, S. R. Kumar, R. Fu, S. Sohn, S. Yousufuddin, M. | Am J Med Qual | 2023 |
Humans |
| Predisposing and Precipitating Factors Associated With Delirium: A Systematic Review | Ormseth, C. H. LaHue, S. C. Oldham, M. A. Josephson, S. A. Whitaker, E. Douglas, V. C. | JAMA Netw Open | 2023 |
Adult |
| Prevalence of pre-operative undiagnosed cognitive impairment and its association with handgrip strength, oral hygiene, and nutritional status in older elective surgical patients in Japan | Nakatani, S. Ida, M. Uyama, K. Kinugasa, Y. Kawaguchi, M. | J Anesth | 2023 |
Humans |
| Preoperative anxiety as an independent predictor of postoperative delirium in older patients undergoing elective surgery for lumbar disc herniation | Mou, Q. Gao, M. Liu, X. Wei, C. Lan, G. Zhao, X. Shan, Y. Wu, C. | Aging Clin Exp Res | 2023 |
Humans |
| Tracheostomy Is Associated With a Decrease in Delirium and Sedation for Intubated COVID-19 Patients | Morton, C. Pisani, M. Doyle, M. Puchalski, J | J Bronchology Interv Pulmonol | 2023 |
Humans |
| Characterising the prodromal phase in dementia with Lewy bodies | Mellergaard, C. Waldemar, G. Vogel, A. Frederiksen, K. S. | Parkinsonism Relat Disord | 2023 |
Humans |
| Mobilisation in the EveNing to TreAt deLirium (MENTAL): protocol for a mixed-methods feasibility randomised controlled trial | McWilliams, D. King, E. Nydahl, P. Darbyshire, J. L. Gallie, L. Barghouthy, D. Bassford, C. Gustafson, O. | BMJ Open | 2023 |
Humans |
| Could a Tailored Exercise Intervention for Hospitalised Older Adults Have a Role in the Resolution of Delirium? Secondary Analysis of a Randomised Clinical Trial | Martinez Velilla, N. Lozano-Vicario, L. Sáez de Asteasu, M. L. Zambom-Ferraresi, F. Galbete, A. Sanchez-Latorre, M. Izquierdo, M. | J Frailty Aging | 2023 |
Humans |
| Dexmedetomidine for the prevention of delirium in adults admitted to the intensive care unit or postoperative care unit: a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis | Maagaard, M. Barbateskovic, M. Andersen-Ranberg, N. C. Kronborg, J. R. Chen, Y. X. Xi, H. H. Perner, A. Wetterslev, J. | Acta Anaesthesiol Scand | 2023 |
Dexmedetomidine |
| High ASA Physical Status and Low Serum Uric Acid to Creatinine Ratio are Independent Risk Factors for Postoperative Delirium Among Older Adults Undergoing Urinary Calculi Surgery | Liu, J. Li, J. Gao, D. Wang, J. Liu, M. Yu, D. | Clin Interv Aging | 2023 |
Humans |
| Dexmedetomidine administration during brain tumour resection for prevention of postoperative delirium: a randomised trial | Li, S. Li, R. Li, M. Cui, Q. Zhang, X. Ma, T. Wang, D. Zeng, M. Li, H. Bao, Z. Peng, Y. Sessler, D. I. | Br J Anaesth | 2023 |
Humans |
| Effect of a repeated verbal reminder of orientation on emergence agitation after general anaesthesia for minimally invasive abdominal surgery: a randomised controlled trial | Lee, S. Sohn, J. Y. Hwang, I. E. Lee, H. J. Yoon, S. Bahk, J. H. Kim, B. R. | Br J Anaesth | 2023 |
delirium |
| A pilot study testing the iOS UB-CAM delirium app | Kuzmik, A. Hannan, J. Boltz, M. Shrestha, P. Husser, E. K. Fick, D. M. Marcantonio, E. R. | J Am Geriatr Soc | 2023 | |
| Use of a nursing-led geriatrics consult service to deliver age-friendly care | Kuntz, A. A. Stumm, E. K. Anderson, T. C. Ibarra, S. J. Markart, M. R. Haske-Palomino, M. | Geriatr Nurs | 2023 |
Acute care |
| Relationship between body mass index and risk of delirium in an intensive care unit | Ko, Y. Kim, H. E. Park, J. Y. Kim, J. J. Cho, J. Oh, J. | Arch Gerontol Geriatr | 2023 |
Body mass index |
| Occurrence of Postoperative Delirium and the Use of Different Assessment Tools | Kirfel, A. Jossen, D. Menzenbach, J. Mayr, A. Wittmann, M. | Geriatrics (Basel) | 2023 |
comparison of postoperative delirium assessments |
| Association of C-reactive protein to albumin ratio with postoperative delirium and mortality in elderly patients undergoing hip fracture surgery: A retrospective cohort study in a single large center | Kim, H. J. Lee, S. Kim, S. H. Lee, S. Sim, J. H. Ro, Y. J. | Exp Gerontol | 2023 |
Aged |
| Relationship Among Clinically Obtained Biomarkers of Inflammation, Hypercoagulability, and Macrophage Activation, and Delirium in Critically Ill Patients With COVID-19 | Khan, S. H. Perkins, A. J. Chi, R. Seyffert, S. Conrad, P. Lindroth, H. Wang, S. Mulkey, M. Gao, S. Khan, B. | Crit Care Explor | 2023 |
Covid-19 |
| Lower Preoperative Verbal Memory Performance Is Associated with Delirium after Coronary Artery Bypass Graft Surgery: A Prospective Cohort Study | Kaźmierski, J. Miler, P. Pawlak, A. Woźniak, J. Frankowska, E. Nowakowska, K. Kuchta, K. Pazdrak, M. Woźniak, K. Magierski, R. Krejca, M. Wilczyński, M. | Arch Clin Neuropsychol | 2023 |
Humans |
| Postoperative Delirium After Intracranial Surgery: A Retrospective Cohort Study | Kappen, P. R. Kappen, H. J. Dirven, C. M. F. Klimek, M. Jeekel, J. Andrinopoulou, E. R. Osse, R. J. Vincent, Ajpe | World Neurosurg | 2023 |
Health outcomes |
| Actigraphy-based sleep and activity measurements in intensive care unit patients randomized to ramelteon or placebo for delirium prevention | Jaiswal, S. J. Bagsic, S. R. S. Takata, E. Kamdar, B. B. Ancoli-Israel, S. Owens, R. L. | Sci Rep | 2023 |
Humans |
| Visualizing how to use antipsychotics for agitated delirium in the last days of life | Imai, K. Morita, T. Mori, M. Kikuchi, D. Yokomichi, N. Miwa, S. Okamoto, S. I. Yamauchi, T. Naito, A. S. D. Matsuda, Y. Maeda, I. Sugano, K. Inanga, M. Inoue, S. Satomi, E. | J Pain Symptom Manage | 2023 |
antipsychotics |
| Is postoperative delirium an independent risk factor for poorer quality of life with long-term cognitive and functional decline after cardiac surgery? | Hu, F. H. Chen, H. L. | J Clin Anesth | 2023 | |
| Diagnostic accuracy of the 4AT for delirium: A systematic review and meta-analysis | Hou, L. Zhang, Q. Cao, L. Chen, M. Wang, Q. Li, Y. Li, S. Ge, L. Yang, K. | Asian J Psychiatr | 2023 |
Humans |
| Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols | Horacek, J. Janda, R. Görnerova, N. Jajcay, L. Andrashko, V. | Neurosci Lett | 2023 |
Anesthesia |
| Evaluation of Education and Patient Screening for Delirium Among Patients With Stroke: Knowledge, Confidence, and Patient Outcomes | Herrera, E. Rutherford, W. Plume, T. Fields, W. Mollon, D. | J Contin Educ Nurs | 2023 |
Humans |
| The kynurenine pathway implicated in patient delirium: possible indications for indoleamine 2,3 dioxygenase inhibitors | Heimberger, A. B. Lukas, R. V. | J Clin Invest | 2023 |
Humans |
| Family presence during critical illness may protect against delirium | Hart, J. L. | Evid Based Nurs | 2023 |
Critical Care Nursing |
| Risk factors for delirium in advanced cancer patients: A systematic review and meta-analysis | Guo, Y. Mu, Y. Wu, T. Xu, Q. Lin, X. | Eur J Oncol Nurs | 2023 |
Advanced cancer |
| Prevention of physical restraints in the acute care setting (PROTECT): study protocol for a cluster-randomised controlled pilot study | Gottschalk, S. Meyer, G. Haastert, B. Abraham, J. | BMJ Open | 2023 |
Humans |
| Association Between the FRAIL Scale and Postoperative Complications in Older Surgical Patients: A Systematic Review and Meta-Analysis | Gong, S. Qian, D. Riazi, S. Chung, F. Englesakis, M. Li, Q. Huszti, E. Wong, J. | Anesth Analg | 2023 |
Humans |
| Phenobarbital to manage severe gamma-hydroxybutyrate withdrawal: A case series | Freeman, G. Siefried, K. J. Roberts, D. M. Rodgers, C. Nic Ionmhain, U. Ramanathan, J. Ezard, N. Brett, J. | Drug Alcohol Rev | 2023 |
Humans |
| The Modified and Extended Hospital Elder Life Program: A remote model of care to expand delirium prevention | Fong, T. G. Albaum, J. A. Anderson, M. L. Cohen, S. G. Johnson, S. Supiano, M. A. Vlisides, P. E. Wade, H. L. Weinberg, L. Wierman, H. R. Zachary, W. Inouye, S. K. | J Am Geriatr Soc | 2023 |
Covid-19 |
| Contribution of intraoperative electroencephalogram suppression to frailty-associated postoperative delirium: mediation analysis of a prospective surgical cohor | Fang, P. P. Shang, Z. X. Xu, J. Hu, J. Zhang, S. C. Fan, Y. G. Lu, Y. Liu, X. S. Maze, M. | Br J Anaesth | 2023 |
Humans |
| Nighttime dexmedetomidine for postoperative delirium prevention: a promising step forward | Devlin, J. W. Hughes, C. G. | EClinicalMedicine | 2023 |
CI, Confidence Intervals |
| Intraoperative infusion of dexmedetomidine for prevention of postoperative delirium in elderly patients undergoing craniotomy: a protocol of randomised clinical trial | Cui, Q. Ma, T. Liu, M. Shen, Z. Li, S. Zeng, M. Liu, X. Zhang, L. Peng, Y. | BMJ Open | 2023 |
Humans |
| Evaluating Implementation and Outcomes of a Person-Centered Care Model for People with Dementia in the Rehabilitation In-Patient Setting: Project Protocol | Chenoweth, L. Williams, A. McGuire, J. Reyes, P. Maiden, G. Brodaty, H. Liu, Z. Cook, J. McCade, D. Taylor-Rubin, C. Freeman, M. Burley, C. | J Alzheimers Dis | 2023 |
Delirium |
| Statin Use and Delirium Risk: An Updated Systematic Review and Meta-Analysis | Chang, Y. H. Wang, J. Y. Peng, T. R. Lian, J. H. Lee, M. C. Chen, H. M. | Am J Ther | 2023 | |
| Utility of head computed tomography for older adults with suspected delirium in the emergency department: A retrospective observational study | Butcher, J. D. Smith, M. C. Roberts, L. Ellis, B. | Acad Emerg Med | 2023 |
Humans |
| Hypomagnesemia and incident delirium in hospitalized older persons | Boccardi, V. Ercolani, S. Serra, R. Bubba, V. Piccolo, A. Scamosci, M. Villa, A. Ruggiero, C. Mecocci, P. | Aging Clin Exp Res | 2023 |
Delirium |
| Delirium secondary to anticholinergics | Bellizzi, A. Mercieca, E. Dimech, C. | BMJ Case Rep | 2023 |
Male |
| The Effectiveness of Dexmedetomidine as a Prophylactic Treatment for Emergence Delirium Among Combat Veterans With High Anxiety: A Randomized Placebo-Controlled Trial | Bartoszek, M. McGuire, J. M. Wilson, J. T. Sorensen, J. S. Vice, T. F. R. Hudson, A. J. | Mil Med | 2023 |
Humans |
| Implementing an intervention to enhance care delivery and consistency for people with hip fracture and cognitive impairment in acute hospital wards: a mixed methods process evaluation of a randomised controlled feasibility trial (PERFECTED) | Backhouse, T. Fox, C. Hammond, S. P. Poland, F. McDermott-Thompson, V. Penhale, B. Cross, J. L. | BMJ Open | 2023 |
Humans |
| Association of delirium with increased short-term mortality among older emergency department patients: A cohort study | Arneson, M. L. Oliveira, J. E. Silva L. Stanich, J. A. Jeffery, M. M. Lindroth, H. L. Ginsburg, A. D. Bower, S. M. Mullan, A. F. Bellolio, F. | Am J Emerg Med | 2023 |
Delirium |
| Catatonia and Delirium: Assessment of Comorbidity, Prevalence, and Therapeutic Response in Medically Ill Inpatients From a University Hospital | Appiani, F. J. Duarte, J. M. Sauré, M. Rodríguez Cairoli, F. Momeño, V. Yaryour, C. Sarotto, L. | J Clin Psychopharmacol | 2023 |
Humans |