What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Prospective clinical intervention study of aripiprazole and risperidone in the management of postoperative delirium in elderly patients after cardiovascular surgery | Sugawara, H. Koyama, A. Maruyama, T. Koda, Y. Fukunaga, H. Ishikawa, T. Takebayashi, M. Okamoto, K. Fukui, T. Hashimoto, M. | Psychiatry Clin Neurosci | 2022 | |
| A simple risk score list can be used to predict the occurrence of delirium in patients admitted to inpatient hospice care: A medical record study | Stoevelaar, R. Juffermans, C. C. M. Roorda, I. M. M. de Nijs, E. J. M. Hoornweg, J. Cannegieter, S. C. van der Linden, Y. M. | Eur J Cancer Care (Engl) | 2022 |
delirium |
| Chemokines in ICU Delirium: An Exploratory Study | Smith, R. J. Rabinstein, A. A. Cartin-Ceba, R. Singh, V. P. Lachner, C. Khatua, B. Trivedi, S. Gajic, O. | Crit Care Explor | 2022 |
chemokine |
| Cytokine profiles in intensive care unit delirium | Smith, R. J. Lachner, C. Singh, V. P. Trivedi, S. Khatua, B. Cartin-Ceba, R. | Acute Crit Care | 2022 |
cytokine |
| Edmonton frailty scale score predicts postoperative delirium: a retrospective cohort analysis | Sieber, F. Gearhart, S. Bettick, D. Wang, N. Y | BMC Geriatr | 2022 |
Cohort Studies |
| Observation of Anesthetic Effect of Dexmedetomidine Combined With Intraspinal Anesthesia in Hip Arthroplasty and its Effect on Postoperative Delirium and Stress Response | Shen, Y. Wang, C. Zhong, X. Wu, Y. He, X. | Front Surg | 2022 |
anesthetic effects |
| Postoperative Application of Dexmedetomidine is the Optimal Strategy to Reduce the Incidence of Postoperative Delirium After Cardiac Surgery: A Network Meta-Analysis of Randomized Controlled Trials | Shang, L. Hou, M. Guo, F. | Ann Pharmacother | 2022 |
cardiac surgery |
| Decreasing delirium through music listening (DDM) in critically ill, mechanically ventilated older adults in the intensive care unit: a two-arm, parallel-group, randomized clinical trial | Seyffert, S. Moiz, S. Coghlan, M. Balozian, P. Nasser, J. Rached, E. A. Jamil, Y. Naqvi, K. Rawlings, L. Perkins, A. J. Gao, S. Hunter, J. D., 3rd Khan, S. Heiderscheit, A. Chlan, L. L. Khan, B. | Trials | 2022 |
Aged |
| Prevention of delirium with agitation by yokukansan in older adults after cancer surgery | Sadahiro, R. Wada, S. Matsuoka, Y. J. Uchitomi, Y. Yamaguchi, T. Sato, T. Esaki, M. Yoshimoto, S. Daiko, H. Kanemitsu, Y. Kawai, A. Kato, T. Fujimoto, H. Uezono, Y. Shimizu, K. Matsuoka, H. | Jpn J Clin Oncol | 2022 |
clinical trial |
| Midazolam impacts acetyl-And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium? | Rump, K. Holtkamp, C. Bergmann, L. Nowak, H. Unterberg, M. Orlowski, J. Thon, P. Bazzi, Z. Bazzi, M. Adamzik, M. Koos, B. Rahmel, T. | PLoS One | 2022 |
Acetylcholinesterase/metabolism |
| Ren, X. Zhang, S. Yang, Y. Song, A. Liang, F. Zhang, Y. Dong, Y. Wu, X. Xie, Z. | Ketamine Induces Delirium-Like Behavior and Interferes With Endosomal Tau Trafficking | Anesth Analg | 2022 | |
| The crucial factors influencing the development and outcomes of postoperative delirium in proximal femur fractures | Rajeev, A. Railton, C. Devalia, K. | Aging Med (Milton) | 2022 |
delirium |
| Neuromonitoring depth of anesthesia and its association with postoperative delirium | Pérez-Otal, B. Aragón-Benedí, C. Pascual-Bellosta, A. Ortega-Lucea, S. Martínez-Ubieto, J. Ramírez-Rodríguez, J. M. | Sci Rep | 2022 |
Anesthesia, General/adverse effects |
| Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care | Pearson, M. Jackson, G. Jackson, C. Boland, J. Featherstone, I. Huang, C. Ogden, M. Sartain, K. Siddiqi, N. Twiddy, M. Johnson, M. | BMJ Open | 2022 |
*Delirium/diagnosis/prevention & control |
| An Interdisciplinary Reappraisal of Delirium and Proposed Subtypes | Oldham, M. A. Slooter, A. J. C. Ely, E. W. Crone, C. Maldonado, J. R. Rosenthal, L. J. | J Acad Consult Liaison Psychiatry | 2022 |
acute encephalopathy |
| Postoperative Delirium in Patients with Oral Cancer: Is Intraoperative Fluid Administration a Neglected Risk Factor? | Obermeier, K. T. Kraus, M. Smolka, W. Henkel, J. Saller, T. Otto, S. Liokatis, P. | Cancers (Basel) | 2022 |
fluid balance |
| Risk of delirium associated with antimuscarinics in older adults: A case-time-control study | Nishtala, P. S. Chyou, T. Y. | Pharmacoepidemiol Drug Saf | 2022 |
Aged |
| Potential effects of regular use of antihypertensive drugs for in-hospital delirium in geriatric patients with trauma | Nagasawa, H. Omori, K. Ota, S. Muramatsu, K. I. Ishikawa, K. Yanagawa, Y. | Sci Rep | 2022 |
Aged |
| Performance of Melatonin as Prophylaxis in Geriatric Patients with Multifactorial Risk for Postoperative Delirium Development: A Randomized Comparative Study | Mohamed, S. A. Rady, A. Youssry, M. Abdelaziz Mohamed, M. R. Gamal, M. | Turk J Anaesthesiol Reanim | 2022 | |
| Perioperative risk factors associated with increased incidence of postoperative delirium: systematic review, meta-analysis, and Grading of Recommendations Assessment, Development, and Evaluation system report of clinical literature | Mevorach, L. Forookhi, A. Farcomeni, A. Romagnoli, S. Bilotta, F. | Br J Anaesth | 2022 |
Grade |
| Delirium in ICU Patients after Cardiac Arrest: A Scoping Review | Mędrzycka-Dąbrowska, W. Lange, S. Religa, D. Dąbrowski, S. Friganović, A. Oomen, B. Krupa, S. | J Pers Med | 2022 |
Icu |
| Epidemiology of delirium in hospitalized patients in Latin America: A systematic review | Maximiliano, B. Sebastian, B. Estefania, A. Irma, C. Gutierrez, P. Daniela, P. Pv Roberta, C. Eduardo, T. Jose, M. Felipe, S. | Acta Psychiatr Scand | 2022 |
Latin America |
| Effect of Perioperative Dexmedetomidine Infusion on Postoperative Delirium in Elderly Patients Undergoing Oral and Maxillofacial Surgery: A Randomized Controlled Clinical Trial | Liu, T. Tuo, J. Wei, Q. Sun, X. Zhao, H. Zhao, X. Qu, M. | Int J Gen Med | 2022 |
dexmedetomidine |
| Type 2 Diabetes Mellitus with Tight Glucose Control and Poor Pre-Injury Stair Climbing Capacity May Predict Postoperative Delirium: A Secondary Analysis | Liu, K. Song, Y. Yuan, Y. Li, Z. Wang, X. Zhang, W. Li, Y. Mi, X. Han, D. Rong, Y. Guo, X. Wang, G. | Brain Sci | 2022 |
glycemic control |
| Preoperative Plasma Tau-PT217 and Tau-PT181 Are Associated With Postoperative Delirium | Liang, F. Baldyga, K. Quan, Q. Khatri, A. Choi, S. Wiener-Kronish, J. Akeju, O. Westover, B. M. Cody, K. Shen, Y. Marcantonio, E. R. Xie, Z. | Ann Surg | 2022 | |
| Development and Validation of Simplified Delirium Prediction Model in Intensive Care Unit | Kim, M. K. Oh, J. Kim, J. J. Park, J. Y. | Front Psychiatry | 2022 |
critical care |
| The effects of hypomagnesemia on delirium in middle-aged and older adult patients admitted to medical intensive care units | Kim, J. Y. Lee, H. J. Lee, H. Y. Lee, S. M. Lee, J. Park, T. Y. | Acute Crit Care | 2022 |
delirium |
| Structural integrity of the anterior mid-cingulate cortex contributes to resilience to delirium in SuperAging | Katsumi, Y. Wong, B. Cavallari, M. Fong, T. G. Alsop, D. C. Andreano, J. M. Carvalho, N. Brickhouse, M. Jones, R. Libermann, T. A. Marcantonio, E. R. Schmitt, E. Shafi, M. M. Pascual-Leone, A. Travison, T. Barrett, L. F. Inouye, S. K. Dickerson, B. C. Tou | Brain Commun | 2022 |
Mri |
| "Excited delirium," erroneous concepts, dehumanizing language, false narratives, and threat to Black lives | Fiscella, K. Pinals, D. A. Shields, C. G. | Acad Emerg Med | 2022 |
*Delirium/diagnosis |
| Knowing the Older Adult With Delirium Superimposed on Dementia | Fick, D. M. | Am J Geriatr Psychiatry | 2022 |
Delirium |
| Bibliometric Analysis of 100 Most-Cited Articles in Delirium | Fei, X. Zeng, Q. Wang, J. Gao, Y. Xu, F. | Front Psychiatry | 2022 |
bibliometric analysis |
| Transcutaneous Electrical Acupoint Stimulation Combined With Auricular Acupressure Reduces Postoperative Delirium Among Elderly Patients Following Major Abdominal Surgery: A Randomized Clinical Trial | Fan, Q. Lei, C. Wang, Y. Yu, N. Wang, L. Fu, J. Dong, H. Lu, Z. Xiong, L. | Front Med (Lausanne) | 2022 |
abdominal surgery |
| Depression is associated with delirium after cardiac surgery-a population-based cohort study | Falk, A. Kåhlin, J. Nymark, C. Hultgren, R. Stenman, M. | Interact Cardiovasc Thorac Surg | 2022 |
Aged |
| Association of delirium screening on hospitalized adults and postacute care utilization: A retrospective cohort study | Dulin, J. D. Zhang, J. Marsden, J. Mauldin, P. D. Moran, W. P. Kalivas, B. C. | Am J Med Sci | 2022 | |
| Adaptation, implementation, and mixed methods evaluation of an interprofessional modular clinical practice guideline for delirium management on an inpatient palliative care unit | Bush, S. H. Skinner, E. Lawlor, P. G. Dhuper, M. Grassau, P. A. Pereira, J. L. MacDonald, A. R. Parsons, H. A. Kabir, M. | BMC Palliat Care | 2022 |
Adult |
| Older age, delirium, dementia, frailty, and critical care: Care priorities | Bloomer, M. J. Woszczeiko, C. Hutchinson, A. M. | Intensive Crit Care Nurs | 2002 |
Critical care |
| Early Diagnosis of Delirium in Palliative Care Patients Decreases Mortality and Necessity of Palliative Sedation: Results of a Prospective Observational Study | Beretta, M. Uggeri, S. Santucci, C. Cattaneo, M. Ermolli, D. Gerosa, C. Ornaghi, M. Roccasalva, A. Santambrogio, P. Varrassi, G. Corli, O. | Cureus | 2022 |
clinical outcome |
| Incidence and associations of hospital delirium diagnoses in 85,979 people with severe mental illness: A data linkage study | Bauernfreund, Y. Launders, N. Favarato, G. Hayes, J. F. Osborn, D. Sampson, E. L. | Acta Psychiatr Scand | 2022 |
bipolar disorder |
| The Pharmacogenetics of Opiates and Its Impact on Delirium in Mechanically Ventilated Adults: A Pilot Study | Austin, C. A. Szeto, A. Gupta, A. Wiltshire, T. Crona, D. J. Kistler, C. | J Pharm Technol | 2022 |
analgesics |
| Agents intervening against delirium in the intensive care unit trial-Protocol for a secondary Bayesian analysis | Andersen-Ranberg, N. Poulsen, L. M. Perner, A. Hästbacka, J. Morgan, M. P. G. Citerio, G. Oxenbøll-Collet, M. Weber, S. O. Andreasen, A. S. Bestle, M. H. Uslu, B. Pedersen, H. B. S. Nielsen, L. G. Damgaard, K. Jensen, T. B. Sommer, T. Dey, N. Mathiesen, | Acta Anaesthesiol Scand | 2022 |
Adult |
| Increased Direct Current-Electroencephalography Shifts During Induction of Anesthesia in Elderly Patients Developing Postoperative Delirium | Windmann, V. Dreier, J. P. Major, S. Spies, C. Lachmann, G. Koch, S. | Front Aging Neurosci | 2022 |
*dc-eeg |
| The Effect of Propofol versus Sevoflurane on Postoperative Delirium in Parkinson's Disease Patients Undergoing Deep Brain Stimulation Surgery: An Observational Study | Zhou, Y. Li, Z. Ma, Y. Yu, C. Chen, Y. Ding, J. Yu, J. Zhou, R. Wang, X. Liu, T. Guo, X. Fan, T. Shi, C. | Brain Sci | 2022 |
Parkinson’s disease |
| Association between smoking and postoperative delirium in surgical patients with pulmonary hypertension: a secondary analysis of a cohort study | Zhou, S. Shi, S. Xie, C. Chen, G. | BMC Psychiatry | 2022 |
Cohort Studies |
| Comorbidity patterns in institutionalized older adults affected by dementia | Zazzara, M. B. Vetrano, D. L. Carfì, A. Liperoti, R. Damiano, C. Onder, G. | Alzheimers Dement (Amst) | 2022 |
care pathways |
| The Impact of Perioperative and Predisposing Risk Factors on the Development of Postoperative Delirium and a Possible Gender Difference | Wittmann, M. Kirfel, A. Jossen, D. Mayr, A. Menzenbach, J. | Geriatrics (Basel) | 2022 |
gender difference |
| Four-in-One: A Comprehensive Checklist for the Assessment of Pain, Undersedation, Iatrogenic Withdrawal and Delirium in the PICU: A Delphi Study | van Dijk, M. Ista, E. | Front Pediatr | 2022 |
Iws |
| Analgesia, Sedation, Paralytics, Delirium, and Iatrogenic Withdrawal | Valentine, K. Kummick, J. | Pediatr Clin North Am | 2022 |
*Analgesia |
| Antipsychotic prescribing in people admitted to hospital with dementia or delirium | Tumusiime, W. A. Hardman, C. J. Breen, J. L. | Australas J Ageing | 2022 |
*Antipsychotic Agents/therapeutic use |
| Breaking barriers in postoperative delirium | Terrando, N. Akassoglou, K. | Br J Anaesth | 2022 |
biomarker |
| The Relationship Between Suboptimal Social Networks and Postoperative Delirium: The PNDABLE Study | Tang, X. Yv, H. Wang, F. Wang, J. Liu, S. Wu, X. Dong, R. Lin, X. Wang, B. Bi, Y. | Front Aging Neurosci | 2022 |
cerebrospinal fluid |
| Delirium incidence and risk factors in patients undergoing non-invasive ventilation for acute respiratory failure: a multicenter observational trial | Tabbì, L. Tonelli, R. Comellini, V. Dongilli, R. Sorgentone, S. Spacone, A. Paonessa, M. C. Sacchi, M. Falsini, L. Boni, E. Ribuffo, V. Bruzzi, G. Castaniere, I. Fantini, R. Marchioni, A. Pisani, L. Nava, S. Clini, E. | Minerva Anestesiol | 2022 | |
| The association between Monocyte-to-Lymphocyte ratio and postoperative delirium in ICU patients in cardiac surgery | Su, X. Wang, J. Lu, X. | J Clin Lab Anal | 2022 |
inflammatory markers |
| Development of a non-pharmacologic delirium management bundle in paediatric intensive care units | Stenkjaer, R. L. Herling, S. F. Egerod, I. Weis, J. van Dijk, M. Kudchadkar, S. R. Ramelet, A. S. Ista, E. | Nurs Crit Care | 2022 |
delirium |
| Delirium in hospitalised adults with acute burns - A systematic review | Stanley, G. H. M. Barber, A. R. J. O'Brien, A. M. Hamill, C. Boardman, G. Frear, C. C. Edgar, D. W. Seymour, H. Wood, F. M. | Burns | 2022 |
Burns |
| Delirium associated with buprenorphine use in cardiac surgery: A retrospective cohort study | Selvaraj, T. Thangavel, P. Siddhaarth, K. | Indian J Anaesth | 2022 |
Aged |
| Influence of perioperative dexmedetomidine on the incidence of postoperative delirium in adult patients undergoing cardiac surgery | Patel, M. Onwochei, D. N. Desai, N. | Br J Anaesth | 2022 |
Adult |
| Association Between Implementation of a Geriatric Trauma Clinical Pathway and Changes in Rates of Delirium in Older Adults With Traumatic Injury | Park, C. Bharija, A. Mesias, M. Mitchell, A. Krishna, P. Storr-Street, N. Brown, A. Martin, M. Lu, A. C. Staudenmayer, K. L. | JAMA Surg | 2022 | |
| Intraoperative hyperoxygenation may negatively affect postoperative cognitive functions in coronary artery bypass graft operations: A randomized controlled study | Onur, T. Karaca, Ü Ata, F. Sayan, H. E. Onur, A. Yilmaz, C. Balkaya, A. N. Eriş, C. | J Card Surg | 2022 |
cardiopulmonary bypass |
| Investigation of Risk Factors for Postoperative Delirium after Transcatheter Aortic Valve Implantation: A Retrospective Study | Ogata, Y. Kobayashi, N. Yamauchi, M. | J Clin Med | 2022 |
aortic stenosis |
| Mobilization in the evening to prevent delirium: A pilot randomized trial | Nydahl, P. McWilliams, D. Weiler, N. Borzikowsky, C. Howroyd, F. Brobeil, A. Lindner, M. von Haken, R. | Nurs Crit Care | 2022 |
Critical Care |
| Delirium on stroke units: a prospective, multicentric quality-improvement project | Nydahl, P. Baumgarte, F. Berg, D. Bergjan, M. Borzikowsky, C. Franke, C. Green, D. Hannig, A. Hansen, H. C. Hauss, A. Hansen, U. Istel, R. Krämer, N. Krause, K. Lohrmann, R. Mohammadzadeh-Vazifeh, M. Osterbrink, J. Palm, F. Petersen, T. Schöller, B. Sto | J Neurol | 2022 |
*Delirium/diagnosis/epidemiology/etiology |
| The relationship of acute delirium with cognitive and psychiatric symptoms after stroke: a longitudinal study | Nerdal, V. Gjestad, E. Saltvedt, I. Munthe-Kaas, R. Ihle-Hansen, H. Ryum, T. Lydersen, S. Grambaite, R. | BMC Neurol | 2022 |
Aged |
| Alpha-2-adrenergic receptor agonists for the prevention of delirium and cognitive decline after open heart surgery (ALPHA2PREVENT): protocol for a multicentre randomised controlled trial | Neerland, B. E. Busund, R. Haaverstad, R. Helbostad, J. L. Landsverk, S. A. Martinaityte, I. Norum, H. M. Ræder, J. Selbaek, G. Simpson, M. R. Skaar, E. Skjærvold, N. K. Skovlund, E. Slooter, A. J. Svendsen Ø, S. Tønnessen, T. Wahba, A. Zetterberg, H. | BMJ Open | 2022 |
Adrenergic alpha-2 Receptor Agonists/therapeutic use |
| Does modulation of glymphatic system reduce delirium via waste clearance? | Naaz, S. Asghar, A. | J Anaesthesiol Clin Pharmacol | 2022 | |
| Delirium in elderly postoperative patients: A prospective cohort study | Muzzana, C. Mantovan, F. Huber, M. K. Trevisani, K. Niederbacher, S. Kugler, A. Ausserhofer, D. | Nurs Open | 2022 |
delirium |
| Antimicrobial neurotoxicity: an under-recognised cause of delirium | Moynan, D. Maqbool, E. de Barra, E. | Acute Med | 2022 |
Aged |
| CORR Insights®: Does the SORG Orthopaedic Research Group Hip Fracture Delirium Algorithm Perform Well on an Independent Intercontinental Cohort of Patients With Hip Fractures Who Are 60 Years or Older? | Michelson, J. D. | Clin Orthop Relat Res | 2022 | |
| Drug Choice for Hyperactive Delirium in Terminally-Ill Cancer Patients: A Nationwide Survey | Matsuda, Y. Morita, T. Oya, K. Tagami, K. Naito, A. S. Kashiwagi, H. Otani, H. | J Pain Symptom Manage | 2022 |
cancer |
| Implementing delirium screening in the emergency department: a quality improvement project | Martin, L. Lyons, M. Patton, A. O. Driscoll M McLoughlin, K. Hannon, E. Deasy, C. | BMJ Open Qual | 2022 |
Aged |
| Evaluation of the association of anticholinergic burden and delirium in older hospitalised patients - A cohort study comparing 19 anticholinergic burden scales | Lisibach, A. Gallucci, G. Benelli, V. Kälin, R. Schulthess, S. Beeler, P. E. Csajka, C. Lutters, M. | Br J Clin Pharmacol | 2022 |
Doss |
| Demand Ischemia as a Predictor of Mortality in Older Patients With Delirium | Kumar, M. Patil, S. Godoy, L. D. C. Kuo, C. L. Swede, H. Kuchel, G. A. Chen, K. | Front Cardiovasc Med | 2022 |
clinical outcomes |
| Structured Delirium Management in the Hospital | Krämer, J. Nolte, K. Zupanc, L. Schnitker, S. Roos, A. Göpel, C. Cid, J. S. Eichler, K. Hooven, T. V. D. Hempel, G. Pavenstädt, H. J. Klaas, C. Gosheger, G. Raschke, M. J. Wiendl, H. Duning, T. | Dtsch Arztebl Int | 2022 |
Activities of Daily Living |
| A machine learning approach to identifying delirium from electronic health records | Kim, J. H. Hua, M. Whittington, R. A. Lee, J. Liu, C. Ta, C. N. Marcantonio, E. R. Goldberg, T. E. Weng, C. | JAMIA Open | 2022 |
Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) |
| Effects of nonpharmacological interventions on sleep improvement and delirium prevention in critically ill patients: A systematic review and meta-analysis | Kang, J. Cho, Y. S. Lee, M. Yun, S. Jeong, Y. J. Won, Y. H. Hong, J. Kim, S. | Aust Crit Care | 2022 |
Critical care |
| A machine-learning model to predict postoperative delirium following knee arthroplasty using electronic health records | Jung, J. W. Hwang, S. Ko, S. Jo, C. Park, H. Y. Han, H. S. Lee, M. C. Park, J. E. Ro, D. H. | BMC Psychiatry | 2022 |
*Arthroplasty, Replacement, Knee/adverse effects |
| Tranexamic Acid and the Risk of Delirium after Off-Pump Surgery | Hulde, N. Zittermann, A. Deutsch, M. A. Gummert, J. F. von Dossow, V. Koster, A. | Thorac Cardiovasc Surg | 2022 | |
| Early Serum Metabolism Profile of Post-operative Delirium in Elderly Patients Following Cardiac Surgery With Cardiopulmonary Bypass | Huang, H. Han, J. Li, Y. Yang, Y. Shen, J. Fu, Q. Chen, Y. | Front Aging Neurosci | 2022 |
cardiopulmonary bypass |
| Delirium Item Bank: Utilization to Evaluate and Create Delirium Instruments | Helfand, B. K. I. Tommet, D. Detroyer, E. Milisen, K. Adamis, D. Metzger, E. D. Marcantonio, E. R. Boudreaux, E. D. Inouye, S. K. Jones, R. N. | Dement Geriatr Cogn Disord | 2022 |
Aged |
| Low Dose Antipsychotics for the Treatment of Delirium in Hospitalized Elderly Patients and Their Effects on QTc Interval | Heidari, S. Kargar, M. | J Pharm Pract | 2022 |
adverse drug events |
| Melatonin and Its Analogs for Prevention of Post-cardiac Surgery Delirium: A Systematic Review and Meta-Analysis | Han, Y. Tian, Y. Wu, J. Zhu, X. Wang, W. Zeng, Z. Qin, Z. | Front Cardiovasc Med | 2022 |
cardiac |
| The Role of Acetylcholinesterase Inhibitors in the Treatment of Prolonged Postelectroconvulsive Therapy Delirium | Gutowski, B. Bomasang-Layno, E. | Case Rep Psychiatry | 2022 | |
| Risk factors for delirium in elderly patients after lumbar spinal fusion | Gold, C. Ray, E. Christianson, D. Park, B. Kournoutas, I. A. Kahn, T. A. Perez, E. A. Berger, J. I. Sander, K. Igram, C. A. Pugely, A. Olinger, C. R. Carnahan, R. Chen, P. F. Mueller, R. Hitchon, P. Howard, M. A. Banks, M. Sanders, R. D. Woodroffe, R. W. | Clin Neurol Neurosurg | 2022 |
Geriatric spine surgery |
| Instruments to Identify Delirium in Patients Recovering From Anesthesia: A Scoping Review | Gnatta, J. R. Cavassana, T. M. Nascimento, A. S. D. Poveda, V. B. | J Perianesth Nurs | 2022 |
delirium |
| Identifying Patients With Delirium Based on Unstructured Clinical Notes: Observational Study | Ge, W. Alabsi, H. Jain, A. Ye, E. Sun, H. Fernandes, M. Magdamo, C. Tesh, R. A. Collens, S. I. Newhouse, A. Mvr Moura, L. Zafar, S. Hsu, J. Akeju, O. Robbins, G. K. Mukerji, S. S. Das, S. Westover, M. B. | JMIR Form Res | 2022 |
clinical notes |
| Predictors of post-stroke delirium incidence and duration: results of a prospective observational study using high frequency delirium screening | Fleischmann, R. Andrasch, T. Warwas, S. Kunz, R. Gross, S. Witt, C. Ruhnau, J. Vogelgesang, A. Ulm, L. Mengel, A. von Sarnowski, B. | Int J Stroke | 2022 |
Acute stroke therapy |
| Italian Version of the Cornell Assessment of Pediatric Delirium: Evaluation of the Scale Reliability and Ability to Detect Delirium Compared to Pediatric Intensive Care Unit Physicians Clinical Evaluation | Fazio, P. C. Daverio, M. Masola, M. D'Angelo, I. Frison, S. Zaggia, C. Simeone, S. Pucciarelli, G. Gregori, D. Comoretto, R. Amigoni, A. | Front Pediatr | 2022 |
Capd |
| Regional anesthesia techniques and postoperative delirium: systematic review and meta-analysis | Fanelli, A. Balzani, E. Memtsoudis, S. Abdallah, F. W. Mariano, E. R. | Minerva Anestesiol | 2023 |
Aged |
| Delirium with delayed diagnosis of hereditary coproporphyria | Eroglu, S. Birsenogul, I. | Clin Case Rep | 2022 |
atrial fibrillation |
| The Preventive Effect of Transcutaneous Electrical Acupoint Stimulation on Postoperative Delirium in Elderly Patients with Time Factors: A Randomized Trial | Ding, L. Ning, J. Guo, Y. Wang, Q. Kou, S. Ke, H. Zhou, R. Yu, B. | J Integr Complement Med | 2022 |
inflammation response |
| Prophylactic use of ramelteon for delirium in hospitalized patients: A systematic review and meta-analyses | Dang, V. Mansukhani, M. P. Wang, Z. Vesely, E. K. Kolla, B. P. | J Acad Consult Liaison Psychiatry | 2022 |
Delirium |
| Longest and largest cohort study of delirium to date reinforces association while causation remains elusive | Cunningham, E. | J Neurol Neurosurg Psychiatry | 2022 |
Cognition |
| Documentation and Diagnosis of Delirium in Parkinson's Disease | Cullinan, R. J. Richardson, S. J. Yarnall, A. J. Burn, D. J. Allan, L. M. Lawson, R. A. | Acta Psychiatr Scand | 2022 |
Confusion |
| Avoiding pitfalls in the treatment of delirium | Chuang, Y. C. Lin, C. Y. Wang, J. K. | Aust N Z J Psychiatry | 2022 |
*Delirium/drug therapy |
| Less pharmacotherapy is more in delirium | Chou, S. T. Pogach, M. Rock, L. K. | Intensive Care Med | 2022 |
*Antipsychotic Agents/therapeutic use |
| Accuracies of Training Labels and Machine Learning Models: Experiments on Delirium and Simulated Data | Cheng, Y. Shao, Y. Rudolph, J. Weir, C. R. Sahlmann, B. Zeng-Treitler, Q. | Stud Health Technol Inform | 2022 |
*Delirium |
| E4BP4 Coordinates Circadian Control of Cognition in Delirium | Chen, M. Zhang, L. Shao, M. Du, J. Xiao, Y. Zhang, F. Zhang, T. Li, Y. Zhou, Q. Liu, K. Wang, Z. Wu, B. | Adv Sci (Weinh) | 2022 |
E4bp4 |
| Association Between Anesthetics and Postoperative Delirium in Elderly Patients Undergoing Spine Surgery: Propofol Versus Sevoflurane | Chang, J. E. Min, S. W. Kim, H. Won, D. Lee, J. M. Kim, T. K. Kim, C. Hwang, J. Y. | Global Spine J | 2022 |
anesthesia |
| Validation of a delirium predictive model in patients admitted to surgical intensive care units: a multicentre prospective observational cohort study | Chaiwat, O. Chittawatanarat, K. Mueankwan, S. Morakul, S. Dilokpattanamongkol, P. Thanakiattiwibun, C. Siriussawakul, A. | BMJ Open | 2022 |
Adult |
| Lidocaine Infusion for the Management of Postoperative Pain and Delirium (LIMPP): protocol for a randomised control trial | Buren, M. A. Theologis, A. Zuraek, A. Behrends, M. Clark, A. J. Leung, J. M. | BMJ Open | 2022 |
Aged |
| Factors influencing resilience to postoperative delirium in adults undergoing elective orthopaedic surgery | Bowman, E. M. L. Cardwell, C. McAuley, D. F. McGuinness, B. Passmore, A. P. Beverland, D. Zetterberg, H. Schott, J. M. Cunningham, E. L. | Br J Surg | 2022 |