What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Effectiveness of nursing intervention to reduce delirium in adult critically ill - A protocol for a randomized trial | Gómez Tovar, L. O. Henao-Castaño Á, M. | Contemp Clin Trials Commun | 2023 |
Delirium |
| Variations in Clinical Practice: Assessing Clinical Care Processes According to Clinical Guidelines in a National Cohort of Hospice Patients | de Graaf, E. Grant, M. van de Baan, F. Ausems, M. Verboeket-Crul, C. Leget, C. Teunissen, S. | Am J Hosp Palliat Care | 2023 |
Humans |
| Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis | Consoli, D. C. Spitznagel, B. D. Owen, B. M. Kang, H. Williams Roberson, S. Pandharipande, P. Wesley Ely, E. Nobis, W. P. Bastarache, J. A. Harrison, F. E. | Brain Behav Immun | 2023 |
Humans |
| Malignant Catatonia: A Review for the Intensivist | Connell, J. Oldham, M. Pandharipande, P. Dittus, R. S. Wilson, A. Mart, M. Heckers, S. Ely, E. W. Wilson, J. E. | J Intensive Care Med | 2023 |
Humans |
| Diagnostic yield of CT head in delirium and altered mental status-A systematic review and meta-analysis | Akhtar, H. Chaudhry, S. H. Bortolussi-Courval, É Hanula, R. Akhtar, A. Nauche, B. McDonald, E. G. | J Am Geriatr Soc | 2022 |
CT head |
| Elevation of serum plasminogen activator inhibitor-1 predicts postoperative delirium independent of neural damage: a sequential analysis | Mietani, K. Hasegawa-Moriyama, M. Yagi, K. Inoue, R. Ogata, T. Shimojo, N. Seto, Y. Uchida, K. Sumitani, M. | Sci Rep | 2022 |
Aged |
| Assessing prevalence and independent predictors of postoperative delirium in patients with head and neck cancer. Re: Crawford J E et al Postoperative delirium in patients with head and neck oral cancer in the West of Scotland. Br J Oral Maxillofac Surg 20 | McCaul, J. A. Young, D. McMahon, J. | Br J Oral Maxillofac Surg | 2022 |
*Delirium |
| Preoperative homocysteine modifies the association between postoperative C-reactive protein and postoperative delirium | Ma, X. Mei, X. Tang, T. Wang, M. Wei, X. Zheng, H. Cao, J. Zheng, H. Cody, K. Xiong, L. Marcantonio, E. R. Xie, Z. Shen, Y. | Front Aging Neurosci | 2022 |
C-reactive protein |
| Head Computed Tomography Findings in Geriatric Emergency Department Patients with Delirium, Altered Mental Status, and Confusion: A Systematic Review | Liu, S. W. Lee, S. Hayes, J. M. Khoujah, D. Lo, A. X. Doering, M. de Wit, K. Nickels, C. H. Kennedy, M. Eagles, D. Carpenter, C. Arendts, G. Ragsdale, L. | Acad Emerg Med | 2022 | |
| Potential value of preoperative fasting blood glucose levels in the identification of postoperative delirium in non-diabetic older patients undergoing total hip replacement: The perioperative neurocognitive disorder and biomarker lifestyle study | Liu, S. Xv, L. Wu, X. Wang, F. Wang, J. Tang, X. Dong, R. Wang, B. Lin, X. Bi, Y. | Front Psychiatry | 2022 |
biomarkers |
| New onset delirium prediction using machine learning and long short-term memory (LSTM) in electronic health record | Liu, S. Schlesinger, J. J. McCoy, A. B. Reese, T. J. Steitz, B. Russo, E. Koh, B. Wright, A. | J Am Med Inform Assoc | 2022 |
deep learning |
| The hotspots and publication trends in postoperative delirium: A bibliometric analysis from 2000 to 2020 | Lin, X. Cao, Y. Liu, X. Yu, K. Miao, H. Li, T. | Front Aging Neurosci | 2022 |
Pod |
| Donepezil treatment is associated with improved outcomes in critically ill dementia patients via a reduction in delirium | Lieberman, O. J. Lee, S. Zabinski, J. | Alzheimers Dement | 2022 |
acetylcholine |
| Association of Incident Delirium With Short-term Mortality in Adults With Critical Illness Receiving Mechanical Ventilation | Li, H. C. Yeh, T. Y. Wei, Y. C. Ku, S. C. Xu, Y. J. Chen, C. C. Inouye, S. Boehm, L. M. | JAMA Netw Open | 2022 |
Adult |
| A Nomogram to Predict Delirium after Hip Replacement in Elderly Patients with Femoral Neck Fractures | Li, B. Ju, J. Zhao, J. Qin, Y. Zhang, Y. | Orthop Surg | 2022 |
Femoral neck fracture |
| Immunological risk factors for sepsis-associated delirium and mortality in ICU patients | Lei, W. Ren, Z. Su, J. Zheng, X. Gao, L. Xu, Y. Deng, J. Xiao, C. Sheng, S. Cheng, Y. Ma, T. Liu, Y. Wang, P. Luo, O. J. Chen, G. Wang, Z. | Front Immunol | 2022 |
Complement C3 |
| Postoperative Delirium in Patients Receiving Hip Bipolar Hemiarthroplasty for Displaced Femoral Neck Fractures: The Risk Factors and Further Clinical Outcomes | Lee, D. H. Chang, C. H. Chang, C. W. Chen, Y. C. Tai, T. W. | J Arthroplasty | 2022 |
bipolar hemiarthroplasty |
| Appraisal of Clinical Practice Guideline: Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU | Lang, J. | J Physiother | 2022 |
Adult |
| Validation of the Korean Version of the Delirium Diagnostic Tool-Provisional (K-DDT-Pro) | Kim, K. M. Shim, M. S. Yi, D. Jeon, S. Y. Kim, J. L. | Psychiatry Investig | 2022 |
Delirium |
| Trazodone and Mianserin for Delirium: A Retrospective Chart Review | Kawano, S. Ide, K. Kodama, K. Kikuchi, Y. Sugihara, H. Fujisawa, D. Uchida, H. Mimura, M. Takeuchi, H. | J Clin Psychopharmacol | 2022 | |
| PAINT I: the effect of art therapy in preventing and managing delirium among hospitalized older adults in the PAINT I study-a proof-of-concept trial | Katrin, S. Masuch, J. Lim, S. Habboub, B. Gosch, M. | Eur Geriatr Med | 2022 |
Art therapy |
| Building collaborative relationships with family caregivers of hospitalized older persons with delirium superimposed on dementia: A qualitative study | Julian, P. Ploeg, J. Kaasalainen, S. Markle-Reid, M. | J Adv Nurs | 2022 |
acute care |
| Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery: A Randomized Clinical Trial | Jiang, J. L. Zhang, L. He, L. L. Yu, H. Li, X. F. Dai, S. H. Yu, H. | Anesth Analg | 2022 | |
| The Effect of Scenario-Based Learning on the Performance of Nurses Regarding Delirium in Cardiac Surgery Intensive Care Units: A Quasi-Experimental Study | Jahanbazi, A. Jokar, F. Kheirollahi, N. | Iran J Nurs Midwifery Res | 2022 |
Delirium |
| Influence of cardioplegic solution on incidence of delirium after CABG surgery: Use of Calafiore blood cardioplegia versus HTK - Bretschneider - solution in a single-center retrospective analysis from 2017 to 2021 | Irqsusi, M. Loos, D. Dielmann, K. Ramzan, R. Wulf, H. Ghazy, T. Vogt, S. Rastan, A. J. | J Card Surg | 2022 |
CABG procedure |
| Should neuroleptics be used in patients with delirium seen by palliative care? | Hui, D. Agar, M. Maeda, I. | J Pain Symptom Manage | 2022 |
antipsychotic agents |
| Risk factors for postoperative delirium in elderly urological patients: A meta-analysis | Hua, Y. Chen, S. Xiong, X. Lin, C. Li, D. Tu, P. | Medicine (Baltimore) | 2022 |
Aged |
| Successful aging after elective surgery II: Study design and methods | Hshieh, T. T. Schmitt, E. M. Fong, T. G. Arnold, S. Cavallari, M. Dickerson, B. C. Dillon, S. T. Jones, R. N. Libermann, T. A. Marcantonio, E. R. Pascual-Leone, A. Shafi, M. M. Touroutoglou, A. Travison, T. G. Gou, R. Y. Tommet, D. Abdeen, A. Earp, B. Kun | J Am Geriatr Soc | 2022 |
biomarkers |
| Overestimation of the Causal Effects of Medications on Delirium During Postoperative Hospital Days | Hindman, B. J. Dexter, F. | Anesth Analg | 2022 |
Humans |
| A new medication-based prediction score for postoperative delirium in surgical patients: Development and proof of feasibility in a retrospective patient cohort | Hindelang, V. Dimitriadis, K. Saller, T. Golla, K. Mannell, H. Hug, M. J. Strobach, D. | Pharmazie | 2022 |
Humans |
| Forecasting Postoperative Delirium in Older Adult Patients with Fast-and-Frugal Decision Trees | Heinrich, M. Woike, J. K. Spies, C. D. Wegwarth, O. | J Clin Med | 2022 |
clinical data prediction |
| Association of Delirium Incidence with Visitation Restrictions due to COVID-19 Pandemic in Patients with Acute Cerebrovascular Disease in a Stroke-Unit Setting: A Retrospective Cohort Study | Hahn, M. Gröschel, S. Gröschel, K. Uphaus, T. | Gerontology | 2022 |
COVID-19 pandemic |
| Nurses' assessment of subsyndromal delirium and barriers to assessment: A cross-sectional survey in the intensive care unit | Gao, Y. Zhang, C. Liao, C. Gan, X. | J Nurs Manag | 2022 |
barriers |
| Anxiety as a Risk Factor for Postoperative Delirium in Elective Spine Deformity Surgeries: A National Database Study | Freedman, Z. Hudock, N. Hallan, D. R. Kelleher, J. | Cureus | 2022 |
anxiety |
| Presurgical diffusion metrics of the thalamus and thalamic nuclei in postoperative delirium: A prospective two-centre cohort study in older patients | Fislage, M. Winzeck, S. Stamatakis, E. Correia, M. M. Preller, J. Feinkohl, I. Spies, C. D. Hendrikse, J. J. C. Slooter A Winterer, G. Pischon, T. Menon, D. K. Zacharias, N. | Neuroimage Clin | 2022 |
Diffusion kurtosis imaging |
| Long-Term Intensive Care Unit (ICU) Stays Can Lead to Long-Term Cognitive Impairment (LTCI): Neurosurgery Nursing Strategies to Minimize Risk | Fiani, B. Figueras, R. A. Samones, P. Lee, C. Castillo, A. Sangalang, B. Garcia Perez, F. | Cureus | 2022 |
cognitive impairment |
| Future without delirium: not quite there yet but we can start by prescribing touch | Fernandes, S. M. Adão-Serrano, M. Rodrigues, A. R. Belo, P. | Crit Care | 2022 |
Humans |
| Using Music for the Prevention of Delirium in Patients After Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial | Esfahanian, F. Mirmohammadsadeghi, A. Gholami, H. Neshat, S. Mansouri, M. Sadeghi, M. Bathaie, S. R. Heidari, Z. Mirmohammadsadeghi, M. | J Cardiothorac Vasc Anesth | 2022 |
clinical trial |
| The association of chronic pain and postoperative delirium: a prospective observational cohort study | Eckert, S. C. Spies, C. D. Mörgeli, R. Kruppa, J. Heinrich, M. | Minerva Anestesiol | 2022 | |
| Functional brain network and trail making test changes following major surgery and postoperative delirium: a prospective, multicentre, observational cohort study | Ditzel, F. L. van Montfort, S. J. T. Vernooij, L. M. Kant, I. M. J. Aarts, E. Spies, C. D. Hendrikse, J. Slooter, A. J. C. van Dellen, E. | Br J Anaesth | 2022 |
brain network |
| Comparison of Intravenous and Inhalational Anesthetic on Postoperative Cognitive Outcomes in Elderly Patients Undergoing Cancer Surgery: Systematic Review and Meta-analysis | Ding, Y. Yu, J. Cui, F. Li, J. | J Perianesth Nurs | 2022 |
Aged |
| Examining Subjective Psychological Experiences of Postoperative Delirium in Older Cardiac Surgery Patients | Cohen, C. L. Atkins, K. J. Evered, L. A. Silbert, B. S. Scott, D. A. | Anesth Analg | 2022 | |
| Instruments to measure postintensive care syndrome: a scoping review protocol | Chu, Y. Timmins, F. Thompson, D. Eustace-Cook, J. | BMJ Open | 2022 |
Adult |
| Leucine-rich glioma-inactivated 1 antibody encephalitis as a rare cause of delirium | Ching, E. Murdoch, H. Mohammed, H. | Geriatr Gerontol Int | 2022 | |
| A novel semiautomatic Chinese keywords instrument screening delirium based on electronic medical records | Chen, L. Li, N. Zheng, Y. Gao, L. Ge, N. Xie, D. Yue, J. | BMC Geriatr | 2022 |
Aged |
| Effect of Preoperative Oral Saline Administration on Postoperative Delirium in Older Persons: A Randomized Controlled Trial | Chen, J. Xie, S. Chen, Y. Qiu, T. Lin, J. | Clin Interv Aging | 2022 |
Humans |
| Frailty and delirium in hospitalized older adults: A systematic review with meta-analysis | Cechinel, C. Lenardt, M. H. Rodrigues, J. A. M. Binotto, M. A. Aristides, M. M. Kraus, R. | Rev Lat Am Enfermagem | 2022 |
Humans |
| QEEG abnormalities in cognitively unimpaired patients with delirium | Carrarini, C. Calisi, D. De Rosa, M. A. Di Iorio, A. D'Ardes, D. Pellegrino, R. Gazzina, S. Pilotto, A. Arighi, A. Carandini, T. Cagnin, A. Mozzetta, S. Gallucci, M. Bonifati, D. M. Costa, C. D'Antonio, F. Bruno, G. Cipollone, F. Babiloni, C. Padovani, A. | J Neurol Neurosurg Psychiatry | 2022 |
Cognition |
| Prediction models for postoperative delirium after cardiac surgery: Systematic review and critical appraisal | Cai, S. Li, J. Gao, J. Pan, W. Zhang, Y. | Int J Nurs Stud | 2022 |
Cardiac surgery |
| Implementing a Delirium Risk Stratification Tool and Rounds to Identify and Prevent Delirium in Hospitalized Older Adults | Byrnes, T. Woodward, J. | J Nurs Care Qual | 2022 | |
| The Assessment of Immediate Postoperative Delirium in Neurologically Intact Adult Patients Admitted to the Post-anesthesia Care Unit: A Cross-Sectional Study | Burad, J. Date, R. Al Ismaili, M. Sharma, P. Kuriakose, N. Kodange, S. Birur, S. K. Al Yaqoubi, K. Al Mawali, A. Padmalayan, A. El Mady, H. Elawdy, M. Jaju, S. Al Abady, A. | Cureus | 2022 |
anesthesia recovery period |
| Deconstructing delirium in the post anaesthesia care unit | Banerji, A. Sleigh, J. W. Voss, L. J. Garcia, P. S. Gaskell, A. L. | Front Aging Neurosci | 2022 |
3d-cam |
| Association between remimazolam and postoperative delirium in older adults undergoing elective cardiovascular surgery: a prospective cohort study | Aoki, Y. Kurita, T. Nakajima, M. Imai, R. Suzuki, Y. Makino, H. Kinoshita, H. Doi, M. Nakajima, Y. | J Anesth | 2022 |
Cardiovascular surgical procedures |
| Haloperidol for the Treatment of Delirium in ICU Patients | Andersen-Ranberg, N. C. Poulsen, L. M. Perner, A. Wetterslev, J. Estrup, S. Hästbacka, J. Morgan, M. Citerio, G. Caballero, J. Lange, T. Kjær, M. N. Ebdrup, B. H. Engstrøm, J. Olsen, M. H. Oxenbøll Collet, M. Mortensen, C. B. Weber, S. O. Andreasen, A | N Engl J Med | 2022 | |
| Needs assessment survey of healthcare providers' perceptions and practices regarding delirium prevention at a university medical center | Alghamdi, B. Koroukian, S. M. Kresevic, D. Drummond, C. K. | Front Aging | 2022 |
assessment |
| Incidence, Associated Factors, and Outcome of Delirium among Patients Admitted to ICUs in Oman | Al-Hoodar, R. K. Lazarus, E. R. Al Omari, O. Al Zaabi, O. | Crit Care Res Pract | 2022 | |
| Dose-dependent relationship between intra-procedural hypoxaemia or hypocapnia and postoperative delirium in older patients | Ahrens, E. Tartler, T. M. Suleiman, A. Wachtendorf, L. J. Ma, H. Chen, G. Kendale, S. M. Kienbaum, P. Subramaniam, B. Wagner, S. Schaefer, M. S. | Br J Anaesth | 2022 |
haemodynamics |
| The Preventive Effect of Dexmedetomidine Against Delirium in Patients with Aortic Dissection: A Retrospective Cohort Study | Zhang, S. Yin, Q. Wang, Y. Yu, K. Shen, P. | Heart Surg Forum | 2022 |
*Aneurysm, Dissecting/complications/surgery |
| Prediction model for delirium in patients with cardiovascular surgery: development and validation | Xu, Y. Meng, Y. Qian, X. Wu, H. Liu, Y. Ji, P. Chen, H. | J Cardiothorac Surg | 2022 |
Calibration |
| Knowledge, attitudes and practices of ICU nurses regarding subsyndromal delirium among 20 hospitals in China: a descriptive cross-sectional survey | Xing, H. Zhu, S. Liu, S. Xia, M. Jing, M. Dong, G. Ni, W. Li, L. | BMJ Open | 2022 |
Attitude of Health Personnel |
| The prevention of delirium in elderly surgical patients with obstructive sleep apnea (PODESA): a randomized controlled trial | Wong, J. Doherty, H. R. Singh, M. Choi, S. Siddiqui, N. Lam, D. Liyanage, N. Tomlinson, G. Chung, F. | BMC Anesthesiol | 2022 |
Acetaminophen |
| Feasibility and potential of a bedside mini-EEG for diagnosing delirium superimposed on dementia | Wijnen, V. J. M. Oudewortel, L. van Luijtelaar, G. Witlox, J. Slooter, A. J. C. van Gool, W. A. | Clin Neurophysiol | 2022 |
Benzodiazepines |
| Recipe for primary prevention of delirium in hospitalized older patients | Vreeswijk, R. Maier, A. B. Kalisvaart, K. J. | Aging Clin Exp Res | 2022 |
Delirium |
| Demographic and clinical characteristics of patients with delirium: analysis of a nationwide Japanese medical database | Ueda, N. Igarashi, M. Okuyama, K. Sano, H. Takahashi, K. P. Qureshi Z Tokita, S. Ogawa, A. Okumura, Y. Okuda, S. | BMJ Open | 2022 |
Aged |
| Pharmacologic Management of Delirium in the Intensive Care Unit | Tiberio, P. J. Prendergast, N. T. Girard, T. D. | Clin Chest Med | 2022 |
*Delirium/drug therapy/etiology |
| Prevalence of Emergence Delirium and Associated Factors among Older Patients Who Underwent Elective Surgery: A Multicenter Observational Study | Tesfaye Mekonin, G. Kelbesa Olika, M. Birhanu Wedajo, M. Tolasa Badada, A. Dukessa Dubiwak, A. Tageza Ilala, T. Gebre, M. N. | Anesthesiol Res Pract | 2022 | |
| Impact of combined epidural anaesthesia/analgesia on postoperative cognitive impairment in patients receiving general anaesthesia: a meta-analysis of randomised controlled studies | Teng, I. C. Sun, C. K. Ho, C. N. Wang, L. K. Lin, Y. T. Chang, Y. J. Chen, J. Y. Chu, C. C. Hsing, C. H. Hung, K. C. | Anaesth Crit Care Pain Med | 2022 |
Adult |
| Computerized tool and interdisciplinary care for older patients with delirium in the emergency department: a novel model in Taiwan | Tan, T. H. Yang, T. Y. Chen, Y. M. Chung, S. Y. Liu, H. H. Yang, P. C. Kao, P. H. Peng, A. C. Shu, Y. M. Chu, Y. S. Tsai, K. T. Hsu, C. C. Ho, C. H. Lin, H. J. Huang, C. C. | Aging Clin Exp Res | 2022 |
Computerized |
| Use of Valproic Acid for the Management of Delirium and Agitation in the Intensive Care Unit | Swayngim, R. Preslaski, C. Dawson, J. | J Pharm Pract | 2022 |
agitation |
| Risk Factors for Acute Postoperative Delirium in Cardiac Surgery Patients >65 Years Old | Spiropoulou, E. Samanidis, G. Kanakis, M. Nenekidis, I. | J Pers Med | 2022 |
acute delirium |
| Systemic immune-inflammation index predicts postoperative delirium in elderly patients after surgery: a retrospective cohort study | Song, Y. Luo, Y. Zhang, F. Ma, Y. Lou, J. Li, H. Liu, Y. Mi, W. Cao, J. | BMC Geriatr | 2022 |
Aged |
| The influence of orthopedic surgery on the incidence of post-operative delirium in geriatric patients: results of a prospective observational study | Sircar, K. Yagdiran, A. Bredow, J. Annecke, T. Eysel, P. Scheyerer, M. J. | J Clin Orthop Trauma | 2022 |
Arthroplasty |
| Paternal Occupation and Delirium Risk in Older Adults: A Potential Marker of Early-Life Exposures | Shiff, H. M. Arias, F. Dufour, A. B. Carr, D. Chen, F. Gou, Y. Jones, R. Schmitt, E. Travison, T. G. Kunicki, Z. J. Okereke, O. I. Inouye, S. K. | Innov Aging | 2022 |
Cognitive reserve |
| Flurbiprofen used in one-lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative delirium | Shen, L. Chen, J. Q. Yang, X. L. Hu, J. C. Gao, W. Chai, X. Q. Wang, D. | Front Psychiatry | 2022 |
flurbiprofen |
| Derivation and validation of a prediction score for postoperative delirium in geriatric patients undergoing hip fracture surgery or hip arthroplasty | Shen, J. An, Y. Jiang, B. Zhang, P. | Front Surg | 2022 |
arthroplasty |
| Cognitive decline and dementia: does delirium matter? | Selbæk, G. Neerland, B. E. | Lancet Healthy Longev | 2022 |
*Cognitive Dysfunction |
| Understanding why delirium is often missed in older emergency department patients: a qualitative descriptive study | Schonnop, R. Dainty, K. N. McLeod, S. L. Melady, D. Lee, J. S. | Cjem | 2022 |
Acute care |
| Association between post-operative delirium and use of volatile anesthetics in the elderly: A real-world big data approach | Saller, T. Hubig, L. Seibold, H. Schroeder, Z. Wang, B. Groene, P. Perneczky, R. von Dossow, V. Hinske, L. C. | J Clin Anesth | 2022 |
Aged [D000368] |
| Risk Factors for Postoperative Delirium Identified | Rosenberg, K. | Am J Nurs | 2022 |
*Delirium/etiology |
| Delirium-associated medication in people at risk. A systematic update review, meta-analyses and GRADE-profiles | Reisinger, M. Reininghaus, E. Z. De Biasi, J. Fellendorf, F. T. Schoberer, D. | Acta Psychiatr Scand | 2022 |
Statements |
| The Predictive Role of Inflammatory Biochemical Markers in Post-Operative Delirium After Vascular Surgery Procedures | Pasqui, E. de Donato, G. Brancaccio, B. Casilli, G. Ferrante, G. Cappelli, A. Palasciano, G. | Vasc Health Risk Manag | 2022 |
Aged |
| Potential Usefulness of Blood Urea Nitrogen to Creatinine Ratio in the Prediction and Early Detection of Delirium Motor Subtype in the Intensive Care Unit | Park, W. R. Kim, H. R. Park, J. Y. Kim, H. E. Cho, J. Oh, J. | J Clin Med | 2022 |
biomarker |
| Perioperative Gabapentin Use and In-Hospital Adverse Clinical Events Among Older Adults After Major Surgery | Park, C. M. Inouye, S. K. Marcantonio, E. R. Metzger, E. Bateman, B. T. Lie, J. J. Lee, S. B. Levin, R. Kim, D. H. | JAMA Intern Med | 2022 | |
| Follow the Money: The Widening Coding Disparity Between Acute Encephalopathy and Delirium | Oldham, M. A. | J Acad Consult Liaison Psychiatry | 2022 |
*Brain Diseases |
| Use of Automated Infrared Pupillometry to Predict Delirium in the Intensive Care Unit: A Prospective Observational Study | Okamoto, S. Ishizawa, M. Inoue, S. Sakuramoto, H. | SAGE Open Nurs | 2022 |
automated infrared pupillometry |
| The Role of High Sensitivity C-reactive Protein to Predict Delirium Persistence in Elderly Patients with Pneumonia: A Prospective Cohort Study | Mulyana, R. Syafrita, Y. Ali, H. Murni, A. W. | Acta Med Indones | 2022 |
Aged |
| Peripheral interleukin-6-associated microglial QUIN elevation in basolateral amygdala contributed to cognitive dysfunction in a mouse model of postoperative delirium | Mu, J. L. Liu, X. D. Dong, Y. H. Fang, Y. Y. Qiu, S. D. Zhang, F. Liu, K. X. | Front Med (Lausanne) | 2022 |
Bla |
| The effect of taurine supplementation on delirium post liver transplantation: A randomized controlled trial | Mottaghi, S. Nikoupour, H. Firoozifar, M. Jalali, S. S. Jamshidzadeh, A. Vazin, A. Shafiekhani, M. | Clin Nutr | 2022 |
Delirium |
| The association of depression and postoperative delirium: we may need more information | Mestres, C. A. Quintana, E. | Interact Cardiovasc Thorac Surg | 2022 |
*Cardiac Surgical Procedures |
| Is mood associated with perception of recovery? Preoperative depression versus postoperative delirium after cardiac surgery | Mennander, A. A. | Interact Cardiovasc Thorac Surg | 2022 |
*Cardiac Surgical Procedures/adverse effects |
| An Automated Algorithm for Determining Sleep Using Single-Channel Electroencephalography to Detect Delirium: A Prospective Observational Study in Intensive Care Units | Matsui, K. Sato, N. Idei, M. Arakida, M. Seino, Y. Ishikawa, J. Y. Nakagawa, M. Akaho, R. Nishimura, K. Nomura, T. | Healthcare (Basel) | 2022 |
critically ill patients |
| Drug Choice for Hyperactive Delirium in Terminally-Ill Cancer Patients: A Nationwide Survey | Matsuda, Y. Morita, T. Oya, K. Tagami, K. Naito, A. S. Kashiwagi, H. Otani, H. | J Pain Symptom Manage | 2022 |
*Delirium/drug therapy |
| Dexmedetomidine potential in attenuating postoperative delirium in elderly patients after total hip joint replacement | Lv, Y. Gu, L. | Rev Assoc Med Bras (1992) | 2022 | |
| Challenges in detecting and managing mild cognitive impairment in primary care: a focus group study in Shanghai, China | Lu, Y. Liu, C. Wells, Y. Yu, D. | BMJ Open | 2022 |
Caregivers/psychology |
| The Age-adjusted Charlson Comorbidity Index predicts post-operative delirium in the elderly following thoracic and abdominal surgery: A prospective observational cohort study | Liu, J. Li, J. He, J. Zhang, H. Liu, M. Rong, J. | Front Aging Neurosci | 2022 |
Age-adjusted Charlson Comorbidity Index |
| Early alteration of peripheral blood lymphocyte subsets as a risk factor for delirium in critically ill patients after cardiac surgery: A prospective observational study | Li, X. Cheng, W. Zhang, J. Li, D. Wang, F. Cui, N. | Front Aging Neurosci | 2022 |
CD4+ T cells |
| Association of electroencephalogram epileptiform discharges during cardiac surgery with postoperative delirium: An observational study | Li, N. Liu, X. Gao, Y. Yin, L. Zhao, W. Ma, R. Ni, X. | Front Surg | 2022 |
cardiac surgery |
| Patients' and Relatives' Experiences of Delirium in the Intensive Care Unit-A Qualitative Study | Lange, S. Mędrzycka-Dąbrowska, W. Friganović, A. Religa, D. Krupa, S. | Int J Environ Res Public Health | 2022 |
Aged |
| Survey on Current Practice of Canadian Physicians Regarding the Investigation in Older Patients with Delirium | Laguë, A. Boucher, V. Joo, P. Yadav, K. Morasse, C. Émond, M. | Can Geriatr J | 2022 |
delirium |
| Clinical phenotypes of delirium in patients admitted to the cardiac intensive care unit | Ko, R. E. Kim, S. Lee, J. Park, S. Bae, D. Choi, K. H. Park, T. K. Chung, C. R. Yang, J. H. | PLoS One | 2022 |
*Delirium/epidemiology/etiology |