What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| High ASA Physical Status and Low Serum Uric Acid to Creatinine Ratio are Independent Risk Factors for Postoperative Delirium Among Older Adults Undergoing Urinary Calculi Surgery | Liu, J. Li, J. Gao, D. Wang, J. Liu, M. Yu, D. | Clin Interv Aging | 2023 |
Humans |
| Dexmedetomidine administration during brain tumour resection for prevention of postoperative delirium: a randomised trial | Li, S. Li, R. Li, M. Cui, Q. Zhang, X. Ma, T. Wang, D. Zeng, M. Li, H. Bao, Z. Peng, Y. Sessler, D. I. | Br J Anaesth | 2023 |
Humans |
| Effect of a repeated verbal reminder of orientation on emergence agitation after general anaesthesia for minimally invasive abdominal surgery: a randomised controlled trial | Lee, S. Sohn, J. Y. Hwang, I. E. Lee, H. J. Yoon, S. Bahk, J. H. Kim, B. R. | Br J Anaesth | 2023 |
delirium |
| A pilot study testing the iOS UB-CAM delirium app | Kuzmik, A. Hannan, J. Boltz, M. Shrestha, P. Husser, E. K. Fick, D. M. Marcantonio, E. R. | J Am Geriatr Soc | 2023 | |
| Use of a nursing-led geriatrics consult service to deliver age-friendly care | Kuntz, A. A. Stumm, E. K. Anderson, T. C. Ibarra, S. J. Markart, M. R. Haske-Palomino, M. | Geriatr Nurs | 2023 |
Acute care |
| Relationship between body mass index and risk of delirium in an intensive care unit | Ko, Y. Kim, H. E. Park, J. Y. Kim, J. J. Cho, J. Oh, J. | Arch Gerontol Geriatr | 2023 |
Body mass index |
| Occurrence of Postoperative Delirium and the Use of Different Assessment Tools | Kirfel, A. Jossen, D. Menzenbach, J. Mayr, A. Wittmann, M. | Geriatrics (Basel) | 2023 |
comparison of postoperative delirium assessments |
| Association of C-reactive protein to albumin ratio with postoperative delirium and mortality in elderly patients undergoing hip fracture surgery: A retrospective cohort study in a single large center | Kim, H. J. Lee, S. Kim, S. H. Lee, S. Sim, J. H. Ro, Y. J. | Exp Gerontol | 2023 |
Aged |
| Relationship Among Clinically Obtained Biomarkers of Inflammation, Hypercoagulability, and Macrophage Activation, and Delirium in Critically Ill Patients With COVID-19 | Khan, S. H. Perkins, A. J. Chi, R. Seyffert, S. Conrad, P. Lindroth, H. Wang, S. Mulkey, M. Gao, S. Khan, B. | Crit Care Explor | 2023 |
Covid-19 |
| Lower Preoperative Verbal Memory Performance Is Associated with Delirium after Coronary Artery Bypass Graft Surgery: A Prospective Cohort Study | Kaźmierski, J. Miler, P. Pawlak, A. Woźniak, J. Frankowska, E. Nowakowska, K. Kuchta, K. Pazdrak, M. Woźniak, K. Magierski, R. Krejca, M. Wilczyński, M. | Arch Clin Neuropsychol | 2023 |
Humans |
| Postoperative Delirium After Intracranial Surgery: A Retrospective Cohort Study | Kappen, P. R. Kappen, H. J. Dirven, C. M. F. Klimek, M. Jeekel, J. Andrinopoulou, E. R. Osse, R. J. Vincent, Ajpe | World Neurosurg | 2023 |
Health outcomes |
| Actigraphy-based sleep and activity measurements in intensive care unit patients randomized to ramelteon or placebo for delirium prevention | Jaiswal, S. J. Bagsic, S. R. S. Takata, E. Kamdar, B. B. Ancoli-Israel, S. Owens, R. L. | Sci Rep | 2023 |
Humans |
| Visualizing how to use antipsychotics for agitated delirium in the last days of life | Imai, K. Morita, T. Mori, M. Kikuchi, D. Yokomichi, N. Miwa, S. Okamoto, S. I. Yamauchi, T. Naito, A. S. D. Matsuda, Y. Maeda, I. Sugano, K. Inanga, M. Inoue, S. Satomi, E. | J Pain Symptom Manage | 2023 |
antipsychotics |
| Is postoperative delirium an independent risk factor for poorer quality of life with long-term cognitive and functional decline after cardiac surgery? | Hu, F. H. Chen, H. L. | J Clin Anesth | 2023 | |
| Diagnostic accuracy of the 4AT for delirium: A systematic review and meta-analysis | Hou, L. Zhang, Q. Cao, L. Chen, M. Wang, Q. Li, Y. Li, S. Ge, L. Yang, K. | Asian J Psychiatr | 2023 |
Humans |
| Several reasons why ketamine as a neuroplastic agent may have failed to prevent postoperative delirium: Implications for future protocols | Horacek, J. Janda, R. Görnerova, N. Jajcay, L. Andrashko, V. | Neurosci Lett | 2023 |
Anesthesia |
| Evaluation of Education and Patient Screening for Delirium Among Patients With Stroke: Knowledge, Confidence, and Patient Outcomes | Herrera, E. Rutherford, W. Plume, T. Fields, W. Mollon, D. | J Contin Educ Nurs | 2023 |
Humans |
| The kynurenine pathway implicated in patient delirium: possible indications for indoleamine 2,3 dioxygenase inhibitors | Heimberger, A. B. Lukas, R. V. | J Clin Invest | 2023 |
Humans |
| Family presence during critical illness may protect against delirium | Hart, J. L. | Evid Based Nurs | 2023 |
Critical Care Nursing |
| Risk factors for delirium in advanced cancer patients: A systematic review and meta-analysis | Guo, Y. Mu, Y. Wu, T. Xu, Q. Lin, X. | Eur J Oncol Nurs | 2023 |
Advanced cancer |
| Prevention of physical restraints in the acute care setting (PROTECT): study protocol for a cluster-randomised controlled pilot study | Gottschalk, S. Meyer, G. Haastert, B. Abraham, J. | BMJ Open | 2023 |
Humans |
| Association Between the FRAIL Scale and Postoperative Complications in Older Surgical Patients: A Systematic Review and Meta-Analysis | Gong, S. Qian, D. Riazi, S. Chung, F. Englesakis, M. Li, Q. Huszti, E. Wong, J. | Anesth Analg | 2023 |
Humans |
| Phenobarbital to manage severe gamma-hydroxybutyrate withdrawal: A case series | Freeman, G. Siefried, K. J. Roberts, D. M. Rodgers, C. Nic Ionmhain, U. Ramanathan, J. Ezard, N. Brett, J. | Drug Alcohol Rev | 2023 |
Humans |
| The Modified and Extended Hospital Elder Life Program: A remote model of care to expand delirium prevention | Fong, T. G. Albaum, J. A. Anderson, M. L. Cohen, S. G. Johnson, S. Supiano, M. A. Vlisides, P. E. Wade, H. L. Weinberg, L. Wierman, H. R. Zachary, W. Inouye, S. K. | J Am Geriatr Soc | 2023 |
Covid-19 |
| Contribution of intraoperative electroencephalogram suppression to frailty-associated postoperative delirium: mediation analysis of a prospective surgical cohor | Fang, P. P. Shang, Z. X. Xu, J. Hu, J. Zhang, S. C. Fan, Y. G. Lu, Y. Liu, X. S. Maze, M. | Br J Anaesth | 2023 |
Humans |
| Nighttime dexmedetomidine for postoperative delirium prevention: a promising step forward | Devlin, J. W. Hughes, C. G. | EClinicalMedicine | 2023 |
CI, Confidence Intervals |
| Intraoperative infusion of dexmedetomidine for prevention of postoperative delirium in elderly patients undergoing craniotomy: a protocol of randomised clinical trial | Cui, Q. Ma, T. Liu, M. Shen, Z. Li, S. Zeng, M. Liu, X. Zhang, L. Peng, Y. | BMJ Open | 2023 |
Humans |
| Evaluating Implementation and Outcomes of a Person-Centered Care Model for People with Dementia in the Rehabilitation In-Patient Setting: Project Protocol | Chenoweth, L. Williams, A. McGuire, J. Reyes, P. Maiden, G. Brodaty, H. Liu, Z. Cook, J. McCade, D. Taylor-Rubin, C. Freeman, M. Burley, C. | J Alzheimers Dis | 2023 |
Delirium |
| Statin Use and Delirium Risk: An Updated Systematic Review and Meta-Analysis | Chang, Y. H. Wang, J. Y. Peng, T. R. Lian, J. H. Lee, M. C. Chen, H. M. | Am J Ther | 2023 | |
| Utility of head computed tomography for older adults with suspected delirium in the emergency department: A retrospective observational study | Butcher, J. D. Smith, M. C. Roberts, L. Ellis, B. | Acad Emerg Med | 2023 |
Humans |
| Hypomagnesemia and incident delirium in hospitalized older persons | Boccardi, V. Ercolani, S. Serra, R. Bubba, V. Piccolo, A. Scamosci, M. Villa, A. Ruggiero, C. Mecocci, P. | Aging Clin Exp Res | 2023 |
Delirium |
| Delirium secondary to anticholinergics | Bellizzi, A. Mercieca, E. Dimech, C. | BMJ Case Rep | 2023 |
Male |
| The Effectiveness of Dexmedetomidine as a Prophylactic Treatment for Emergence Delirium Among Combat Veterans With High Anxiety: A Randomized Placebo-Controlled Trial | Bartoszek, M. McGuire, J. M. Wilson, J. T. Sorensen, J. S. Vice, T. F. R. Hudson, A. J. | Mil Med | 2023 |
Humans |
| Implementing an intervention to enhance care delivery and consistency for people with hip fracture and cognitive impairment in acute hospital wards: a mixed methods process evaluation of a randomised controlled feasibility trial (PERFECTED) | Backhouse, T. Fox, C. Hammond, S. P. Poland, F. McDermott-Thompson, V. Penhale, B. Cross, J. L. | BMJ Open | 2023 |
Humans |
| Association of delirium with increased short-term mortality among older emergency department patients: A cohort study | Arneson, M. L. Oliveira, J. E. Silva L. Stanich, J. A. Jeffery, M. M. Lindroth, H. L. Ginsburg, A. D. Bower, S. M. Mullan, A. F. Bellolio, F. | Am J Emerg Med | 2023 |
Delirium |
| Catatonia and Delirium: Assessment of Comorbidity, Prevalence, and Therapeutic Response in Medically Ill Inpatients From a University Hospital | Appiani, F. J. Duarte, J. M. Sauré, M. Rodríguez Cairoli, F. Momeño, V. Yaryour, C. Sarotto, L. | J Clin Psychopharmacol | 2023 |
Humans |
| The Relationship between Delirium and Statin Use According to Disease Severity in Patients in the Intensive Care Unit | An, J. Y. Park, J. Y. Cho, J. Kim, H. E. Park, J. Oh, J. | Clin Psychopharmacol Neurosci | 2023 |
APACHE II score |
| Delirium and Healthcare Utilization in Patients Undergoing Hematopoietic Stem Cell Transplantation | Amonoo, H. L. Markovitz, N. H. Johnson, P. C. Kwok, A. Dale, C. Deary, E. C. Daskalakis, E. Choe, J. J. Yamin, N. Gothoskar, M. Cronin, K. G. Fernandez-Robles, C. Pirl, W. F. Chen, Y. B. Cutler, C. Lindvall, C. El-Jawahri, A. | Transplant Cell Ther | 2023 | |
| Comparison of Prognostic Accuracy of 3 Delirium Prediction Models | Amerongen, H. V. N. Stapel, S. Spijkstra, J. J. Ouweneel, D. Schenk, J. | Am J Crit Care | 2023 |
Adult |
| Melatonin or Ramelteon for Delirium Prevention in the Intensive Care Unit: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Aiello, G. Cuocina, M. La Via, L. Messina, S. Attaguile, G. A. Cantarella, G. Sanfilippo, F. Bernardini, R. | J Clin Med | 2023 |
agonist |
| The Role of Insulin-Like Growth Factor 1 in Delirium: A Systematic Review and Meta-Analysis | Adamis, D. Eikelenboom, P. | Dement Geriatr Cogn Disord | 2023 |
Biomarkers |
| Influence of dosing pattern of antipsychotics on treatment outcome of delirium in patients with advanced cancer | Abe, A. Fujisawa, D. Miyajima, K. Takeuchi, E. Takeuchi, M. Mimura, M. Imai, K. Uemura, K. Watanabe, H. Matsuo, N. Matsuda, Y. Maeda, I. Ogawa, A. Yoshiuchi, K. Iwase, S. | Jpn J Clin Oncol | 2023 |
antipsychotics |
| Prone positioning reduces frontal and hippocampal neuronal dysfunction in a murine model of ventilator-induced lung injury | Sparrow, N. A. Guidry, G. Anwar, F. Darwish, S. Kelly, S. A. Karumanchi, S. A. Lahiri, S. | Front Med (Lausanne) | 2022 |
delirium |
| Association between the reactivity of local cerebral oxygen saturation after hypo-to-hypercapnic tests and delirium after abdominal surgery in older adults: A prospective study | Song, J. Cheng, C. Sheng, K. Jiang, L. L. Li, Y. Xia, X. Q. Hu, X. W. | Front Psychiatry | 2022 |
abdominal surgery |
| Cardiac surgery, ICU sedation, and delirium: is dexmedetomidine the silver bullet | Smith, W. Whitlock, E. L. | Curr Opin Anaesthesiol | 2022 | |
| In pursuit of inter-specialty consensus on excited delirium syndrome: a scoping literature review | Slocum, S. Fiorillo, M. Harding, E. Owen, J. Long, R. Dunn, T. Martin, I. | Forensic Sci Med Pathol | 2022 |
Agitation |
| Magnitude and associated factors of delirium among patients attending emergency department at Jimma medical center, Jimma, southwest Ethiopia, 2022 | Sileshy, B. Hailesilasiie, H. Tesfaye, Y. Ababu, H. | BMC Psychiatry | 2022 |
Humans |
| Impact of Subsyndromal Delirium Occurrence and Its Trajectory during ICU Stay | Serafim, R. B. Dal-Pizzol, F. Souza-Dantas, V. Soares, M. Bozza, F. A. Póvoa, P. Luiz, R. R. Lapa, E. Silva J. R. Salluh, J. I. F. | J Clin Med | 2022 |
Icu |
| Association between frailty, delirium, and mortality in older critically ill patients: a binational registry study | Sahle, B. W. Pilcher, D. Litton, E. Ofori-Asenso, R. Peter, K. McFadyen, J. Bucknall, T. | Ann Intensive Care | 2022 |
Clinical decision-making |
| Pharmacologic treatment of delirium symptoms: A systematic review | Sadlonova, M. Duque, L. Smith, D. Madva, E. N. Amonoo, H. L. Vogelsang, J. Staton, S. C. von Arnim, C. A. F. Huffman, J. C. Celano, C. M. | Gen Hosp Psychiatry | 2022 |
Adult |
| Haloperidol Versus Atypical Antipsychotics for Treating Delirium in Intensive Care Unit Patients: A Systematic Review | Sadhu, A. Valencia, C. Fatima, H. Nwankwo, I. Anam, M. Maharjan, S. Amjad, Z. Abaza, A. Vasavada, A. M. Khan, S. | Cureus | 2022 |
atypicalantipsychotics |
| Reporting of outcomes and measures in studies of interventions to prevent and/or treat delirium in older adults resident in long-term care: a systematic review | Russell, G. Rana, N. Watts, R. Roshny, S. Siddiqi, N. Rose, L. | Age Ageing | 2022 |
Humans |
| Research progress on risk factors of delirium in burn patients: A narrative review | Ren, Y. Zhang, Y. Luo, J. Liao, W. Cheng, X. Zhan, J. | Front Psychiatry | 2022 |
burn injury |
| Association of delirium and spatial neglect in right-hemisphere stroke patients | Ott, J. Oh-Park, M. Boukrina, O. | Pm r | 2022 | |
| A quality improvement project addressing the underreporting of delirium in hip fracture patients | Onizuka, N. Huyke-Hernández, F. A. Roby, M. A. Martell, T. F. Scislow, R. M. Jones, S. C. Olson, A. James, N. Switzer, J. A. | Int J Orthop Trauma Nurs | 2022 | |
| Anesthesia and Postoperative Cognitive Impairment: Types of Knowing | Mutch, W. A. C. | Anesth Analg | 2022 |
Humans |
| Delirium detection using GAMMA wave and machine learning: A pilot study | Mulkey, M. Albanese, T. Kim, S. Huang, H. Yang, B. | Res Nurs Health | 2022 |
Humans |
| Cohort profile: the Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog) - a national research and quality registry with a biomaterial collection | Medbøen, I. T. Persson, K. Nåvik, M. Totland, T. H. Bergh, S. Treviño, C. S. Ulstein, I. Engedal, K. Knapskog, A. B. Brækhus, A. Øksengård, A. R. Horndalsveen, P. O. Saltvedt, I. Lyngroth, A. L. Ranhoff, A. H. Skrettingland, D. B. Naik, M. Soares, J | BMJ Open | 2022 |
Humans |
| Evaluation of Suvorexant and Lemborexant for the Prevention of Delirium in Adult Critically Ill Patients at an Advanced Critical Care Center: A Single-Center, Retrospective, Observational Study | Matsuoka, A. Tobita, S. Sogawa, R. Shinada, K. Murakawa-Hirachi, T. Shimanoe, C. Monji, A. Mizoguchi, Y. Miike, T. Sakamoto, Y. | J Clin Psychiatry | 2022 |
Adult |
| Managing delirium in acute inpatient units: A cross-sectional study of nursing teams' knowledge and perceived limitations | Martínez-García, M. Sánchez-López, E. Fernández-Trinidad, M. | Nurs Open | 2022 |
delirium |
| Delirium prevalence, risk factors and outcomes among patients with acute stroke: A multi-centre observational study | Mansutti, I. Saiani, L. Cargnelutti, D. Petrucco, S. Giannina, V. Di Domenico, C. Passadore, P. Palese, A. | J Vasc Nurs | 2022 |
United States |
| DEX, Delirium and Dilemma | Magoon, R. Mahajan, S. Jose, J. | Braz J Cardiovasc Surg | 2022 |
Cardiac Surgery |
| Three key areas in progressing delirium practice and knowledge: recognition and relief of distress, new directions in delirium epidemiology and developing better research assessments | MacLullich, A. M. J. Hosie, A. Tieges, Z. Davis, D. H. J. | Age Ageing | 2022 |
Humans |
| Postoperative delirium after transcatheter aortic valve replacement: An updated systematic review and meta-analysis | Ma, X. Chu, H. Han, K. Shao, Q. Yu, Y. Jia, S. Wang, D. Wang, Z. Zhou, Y. | J Am Geriatr Soc | 2022 |
incidence |
| Effect of Anaesthesia Depth on Postoperative Delirium and Postoperative Cognitive Dysfunction in High-Risk Patients: A Systematic Review and Meta-Analysis | Ling, L. Yang, T. X. Lee, S. W. K. | Cureus | 2022 |
bispectral index monitoring |
| Potential value of cerebrospinal fluid α-synuclein in the identification of postoperative delirium undergoing knee/hip arthroplasty: The perioperative neurocognitive disorder and biomarker lifestyle study | Lin, X. Guo, Y. Dong, R. Wang, B. Bi, Y. | Front Neurosci | 2022 |
biomarker |
| Association between preoperative dementia and hospital mortality in old old patients undergoing elective gastrointestinal surgery | Li, M. Liu, M. Li, C. Zhang, G. Wei, Y. Xu, Y. Li, T. | Aging Clin Exp Res | 2022 |
Humans |
| Effect of remimazolam on the incidence of delirium after transcatheter aortic valve implantation under general anesthesia: a retrospective exploratory study | Kaneko, S. Morimoto, T. Ichinomiya, T. Murata, H. Yoshitomi, O. Hara, T. | J Anesth | 2022 |
Aortic stenosis |
| A survey study of delirium attitudes and knowledge among hospital medicine clinicians | Kaiksow, F. A. Gilmore-Bykovskyi, A. Golden, B. P. | J Am Geriatr Soc | 2022 | |
| Mid- and Long-Term Surgical Outcomes Due to Infective Endocarditis in Elderly Patients: A Retrospective Cohort Study | Jussli-Melchers, J. Salem, M. A. Schoettler, J. Friedrich, C. Huenges, K. Elke, G. Puehler, T. Cremer, J. Haneya, A. | J Clin Med | 2022 |
cardiac surgery |
| Effect of inpatient antibiotic treatment among older adults with delirium found with a positive urinalysis: a health record review | Joo, P. Grant, L. Ramsay, T. Nott, C. Zvonar, R. Jia, J. Yadav, K. Mollanji, E. He, W. Eagles, D. | BMC Geriatr | 2022 |
Humans |
| Correlation Analysis of Inflammatory Markers CRP and IL-6 and Postoperative Delirium (POD) in Elderly Patients: A Meta-Analysis of Observational Studies | Huang, X. Li, L. Feng, Q. | J Environ Public Health | 2022 |
Aged |
| One-year Medicare costs associated with delirium in older hospitalized patients with and without Alzheimer's disease dementia and related disorders | Hshieh, T. T. Gou, R. Y. Jones, R. N. Leslie, D. L. Marcantonio, E. R. Xu, G. Travison, T. G. Fong, T. G. Schmitt, E. M. Inouye, S. K. | Alzheimers Dement | 2022 |
Alzheimer’s dementia |
| Nurses' competence in recognition and management of delirium in older patients: development and piloting of a self-assessment tool | Hoch, J. Bauer, J. M. Bizer, M. Arnold, C. Benzinger, P. | BMC Geriatr | 2022 |
Humans |
| Scoping review of the use of virtual reality in intensive care units | Hill, J. E. Twamley, J. Breed, H. Kenyon, R. Casey, R. Zhang, J. Clegg, A. | Nurs Crit Care | 2022 |
Humans |
| Real-time location systems technology in the care of older adults with cognitive impairment living in residential care: A scoping review | Haslam-Larmer, L. Shum, L. Chu, C. H. McGilton, K. McArthur, C. Flint, A. J. Khan, S. Iaboni, A. | Front Psychiatry | 2022 |
RTLS (Real-time location system) |
| Exercise for acutely hospitalised older medical patients | Hartley, P. Keating, J. L. Jeffs, K. J. Raymond, M. J. Smith, T. O | Cochrane Database Syst Rev | 2022 |
Aged |
| Predictors of hospital readmission for patients diagnosed with delirium: An electronic health record data analysis in South London | Friedrich, M. E. Perera, G. Leutgeb, L. Haardt, D. Frey, R. Stewart, R. Mueller, C. | Acta Psychiatr Scand | 2022 |
30-day readmission rates |
| The impact of ABCDE bundle implementation on patient outcomes: A nationwide cohort study | Frade-Mera, M. J. Arias-Rivera, S. Zaragoza-García, I. Martí, J. D. Gallart, E. San José-Arribas, A. Velasco-Sanz, T. R. Blazquez-Martínez, E. Raurell-Torredà, M. | Nurs Crit Care | 2022 |
Adult |
| Pre- and intraoperative cerebral near-infrared spectroscopy and postoperative delirium: Results of a prospective cross-sectional trial | Fischer-Kumbruch, M. Jung, C. Hinken, L. Trübenbach, D. Fielbrand, R. Schenk, I. Diegmann, O. Krauß, T. Scheinichen, D. Schultz, B. | Medicine (Baltimore) | 2022 |
Aged |
| Filiatreault, S. Grimshaw, J. M. Kreindler, S. A. Chochinov, A. Linton, J. Doupe, M. B. | A critical appraisal of delirium clinical practice guidelines relevant to the care of older adults in the emergency department with a synthesis of recommendations: an umbrella review protocol | Syst Rev | 2022 |
Humans |
| Delirium as late manifestation of infective endocarditis after transcatheter aortic valve implantation | Fantinati, J. Rossi, P. D. Conte, G. Cesari, M. Lucchi, T. Ciccone, S. | Age Ageing | 2022 |
Humans |
| Cognitive function and delirium following sevoflurane or propofol anesthesia for valve replacement surgery: A multicenter randomized controlled trial | Duan, G. Y. Duan, Z. X. Chen, H. Chen, F. Chen, F. Du, Z. Y. Chen, L. Y. Lu, K. Z. Zuo, Z. Y. Li, H. | Kaohsiung J Med Sci | 2022 |
multicenter randomized controlled trial |
| Delirium in the intensive care unit: identifying difficulties in applying the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU | Dos Santos, F. C. M. Rêgo, A. S. Montenegro, W. S. de Carvalho, Strf Cutrim, R. C. Júnior, A. A. M. Pereira, F. H. F. Dibai-Filho, A. V. Bassi-Dibai, D. | BMC Nurs | 2022 |
Intensive care units |
| Aren't you forgetting something? Cognitive screening beyond delirium in the emergency department | de Moraes, G. S. Curiati, P. K. Avelino-Silva, T. J. Morinaga, C. V. Apolinário, D. Suemoto, C. K. Aliberti, M. J. R. | J Am Geriatr Soc | 2022 | |
| Postoperative delirium: An independent risk factor for poorer quality of life with long-term cognitive and functional decline after cardiac surgery | de la Varga-Martínez, O. Gutiérrez-Bustillo, R. Muñoz-Moreno, M. F. López-Herrero, R. Gómez-Sánchez, E. Tamayo, E. | J Clin Anesth | 2022 |
Cardiac surgery |
| Brain-penetrant calcium channel blockers are associated with a reduced incidence of neuropsychiatric disorders | Colbourne, L. Harrison, P. J. | Mol Psychiatry | 2022 |
Humans |
| Gender differences in the correlation between body mass index and cognitive impairment among the community-dwelling oldest-old in China: a cross-sectional study | Chen, N. Cao, J. Zhang, W. Chen, Y. Xu, L. | BMJ Open | 2022 |
Male |
| Association between preoperative on-site CCU visits and postoperative delirium in patients undergoing cardiac surgery: A retrospective cohort study | Chen, B. Wu, L. Fang, Z. Zheng, J. Dong, W. Hong, X. Jin, P. | Nurs Crit Care | 2022 |
cardiac surgery |
| Language discordance in emergency department delirium screening: Results from a qualitative interview-based study | Chary, A. N. Torres, B. Brickhouse, E. Santangelo, I. Godwin, K. M. Naik, A. D. Carpenter, C. R. Liu, S. W. Kennedy, M. | J Am Geriatr Soc | 2022 | |
| Impact of early mobilization on the duration of delirium in elderly hospitalized patients: A retrospective cohort pilot study | Anada, S. Iigaya, M. Takahashi, M. Soda, K. Wada, N. | Medicine (Baltimore) | 2022 |
Male |
| A Recipe for Delirium: Community-Acquired Pneumonia and Sickle Cell Anemia With Moyamoya Disease | Alier, F. Santana, L. Wasey, W. Grubb, L. Satti, A. | Cureus | 2022 |
and transient ischemic attack (tia) |
| Does time to surgery for traumatic hip fracture impact the efficacy of fascia iliaca blocks? A brief report | Akinola, K. Salottolo, K. Meinig, R. Fine, L. Madayag, R. M. Ekengren, F. Tanner, A., 2nd Bar-Or, D. | Trauma Surg Acute Care Open | 2022 |
delirium |
| Longitudinal Profiling of Plasma Cytokines and Its Association With Postoperative Delirium in Elderly Patients Undergoing Major Lower Limb Surgery: A Prospective Observational Study | Zhang, Y. Hu, J. Zuo, W. He, P. Xue, Q. Feng, X. Zhang, Y. Maze, M. | Anesth Analg | 2023 |
Humans |
| The implementation of nUrsiNg DEliRium preventive INterventions in the Intensive Care Unit (UNDERPIN-ICU): A qualitative evaluation | Tilburgs, B. Rood, P. J. T. Zegers, M. van den Boogaard, M. | Int J Nurs Stud | 2023 |
Humans |
| Cardiac surgery, ICU sedation, and delirium: is dexmedetomidine the silver bullet? | Smith, W. Whitlock, E. L. | Curr Opin Anaesthesiol | 2023 |
Humans |
| Inpatient GHB withdrawal management in an inner-city hospital in Sydney, Australia: a retrospective medical record review | Siefried, K. J. Freeman, G. Roberts, D. M. Lindsey, R. Rodgers, C. Ezard, N. Brett, J. | Psychopharmacology (Berl) | 2023 |
Humans |
| Delirium-associated medication in people at risk: A systematic update review, meta-analyses, and GRADE-profiles | Reisinger, M. Reininghaus, E. Z. Biasi, J. Fellendorf, F. T. Schoberer, D. | Acta Psychiatr Scand | 2023 |
Adult |
| Sleep quality and quantity determined by polysomnography in mechanically ventilated critically ill patients randomized to dexmedetomidine or placebo | Oxlund, J. Knudsen, T. Sörberg, M. Strøm, T. Toft, P. Jennum, P. J. | Acta Anaesthesiol Scand | 2023 |
Humans |
| Falls Incidence Compared Between a Multibedded Ward Hospital and a 100% Single-Occupancy Room Hospital: An Uncontrolled Before-After Study | Hussain, F. van Dijk, M. Oudshoorn, C. Ista, E. | Herd | 2023 |
Humans |