What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Withdrawal versus continuation of long-term antipsychotic drug use for behavioural and psychological symptoms in older people with dementia.
- Authors
- Van Leeuwen, E. Petrovic, M. van Driel, M. L. De Sutter, A. I. M. Vander Stichele, R. Declercq, T. Christiaens, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Antipsychotic agents are often used to treat neuropsychiatric symptoms (NPS) in people with dementia although there is uncertainty about the effectiveness of their long-term use for this indication and concern that they may cause harm, including higher mortality. When behavioural strategies have failed and treatment with antipsychotic drugs is instituted, regular attempts to withdraw them have been recommended in guidelines. Physicians, nurses and families of older people with dementia may be reluctant to stop antipsychotics, fearing deterioration of NPS. This is an update of a Cochrane Review published in 2013. Objectives: To evaluate whether withdrawal of antipsychotic agents is successful in older people with dementia and NPS in primary care or nursing home settings, to list the different strategies for withdrawal of antipsychotic agents in older participants with dementia and NPS, and to measure the effects of withdrawal of antipsychotic agents on participants’ behaviour and assess safety. Search methods: We searched the Specialized Register of the Cochrane Dementia and Cognitive Improvement Group (ALOIS), theCochrane Library, MEDLINE, Embase, PsycINFO, CINAHL, LILACS, clinical trials registries and grey literature sources up to 11 January 2018. Selection criteria: We included all randomised, controlled trials comparing an antipsychotic withdrawal strategy to continuation of antipsychotics in people with dementia who had been treated with an antipsychotic drug for at least three months. Data collection and analysis: We used standard methodological procedures according to the Cochrane Handbook for Systematic Reviews of Interventions. We rated the quality of evidence for each outcome using the GRADE approach. Main results: We included 10 studies involving 632 participants. One new trial (19 participants) was added for this update. One trial was conducted in a community setting, eight in nursing homes and one in both settings. Different types of antipsychotics at varying doses were discontinued in the studies. Both abrupt and gradual withdrawal schedules were used. Reported data were predominantly from studies at low or unclear risk of bias. We included nine trials with 575 randomised participants that used a proxy outcome for overall success of antipsychotic withdrawal. Pooling data was not possible due to heterogeneity of outcome measures used. Based on assessment of seven studies, discontinuation may make little or no difference to whether or not participants complete the study (low-quality evidence). Two trials included only participants with psychosis, agitation or aggression who had responded to antipsychotic treatment. In these two trials, stopping antipsychotics was associated with a higher risk of leaving the study early due to symptomatic relapse or a shorter time to symptomatic relapse. We found low-quality evidence that discontinuation may make little or no difference to overall NPS, measured using various scales (7 trials, 519 participants). There was some evidence from subgroup analyses in two trials that discontinuation may reduce agitation for participants with less severe NPS at baseline, but may be associated with a worsening of NPS in participants with more severe NPS at baseline. None of the studies assessed withdrawal symptoms. Adverse effects of antipsychotics (such as falls) were not systematically assessed. Low-quality evidence showed that discontinuation may have little or no effect on adverse events (5 trials, 381 participants), quality of life (2 trials, 119 participants), or cognitive function (5 trials, 365 participants). There were insufficient data to determine whether discontinuation of antipsychotics has any effect on mortality (very low-quality evidence). Authors’ conclusions: There is low-quality evidence that antipsychotics may be successfully discontinued in older people with dementia and NPS who have been taking antipsychotics for at least three months, and that discontinuation may have little or no important effect on behavioural and psychological symptoms. This i consistent with the observation that most behavioural complications of dementia are intermittent and often do not persist for longer than three months. Discontinuation may have little or no effect on overall cognitive function. Discontinuation may make no difference to adverse events and quality of life. Based on the trials in this review, we are uncertain whether discontinuation of antipsychotics leads to a decrease in mortality. People with psychosis, aggression or agitation who responded well to long-term antipsychotic drug use, or those with more severe NPS at baseline, may benefit behaviourally from continuation of antipsychotics. Discontinuation may reduce agitation for people with mild NPS at baseline. However, these conclusions are based on few studies or small subgroups and further evidence of benefits and harms associated with withdrawal of antipsychotic is required in people with dementia and mild and severe NPS. The overall conclusions of the review have not changed since 2013 and the number of available trials remains low.
- PMID
- Keywords
chlorpromazine
haloperidol
levomepromazine
lorazepam
loxapine
mesoridazine
neuroleptic agent
olanzapine
perphenazine
placebo
risperidone
thioridazine
tiotixene
trifluoperazine
aggression
agitation
akathisia
behavior disorder
blood pressure
body equilibrium
cardiovascular disease
cognition
confusion
dementia
drug fatality
drug megadose
drug response
drug safety
drug withdrawal
extrapyramidal symptom
falling
fracture
heart rate
human
insomnia
long term care
low drug dose
lung disease
mental disease
motor dysfunction
nausea
neurologic disease
nursing home
parkinsonism
physical mobility
primary medical care
priority journal
psychosis
quality of life
relapse
restlessness
review
sedation
side effect
systematic review
tardive dyskinesia
treatment outcome
vomiting
- Page(s)
- Volume
- Issue
- 3
Title | Authors | Journal | Year | Keywords |
---|---|---|---|---|
Sedation, analgesia, and delirium management in Portugal: a survey and point prevalence study | Paulino, M. C. Pereira, I. J. Costa, V. Neves, A. Santos, A. Teixeira, C. M. Coimbra, I. Fernandes, P. Bernardo, R. Póvoa, P. Granja, C. | Rev Bras Ter Intensiva | 2022 |
*Analgesia |
Acute kidney injury-associated delirium: a review of clinical and pathophysiological mechanisms | Pang, H. Kumar, S. Ely, E. W. Gezalian, M. M. Lahiri, S. | Crit Care | 2022 |
*Acute Kidney Injury |
Delirium Development After Lung Transplantation: An Intraoperative Assessment | Ozay, H. Y. Bindal, M. Turkkan, S. Beyoglu, M. A. Yekeler, E. Turan, S. | Transplant Proc | 2022 | |
Delirium severity does not differ between medical and surgical intensive care units after adjusting for medication use | Ortiz, D. Lindroth, H. L. Braly, T. Perkins, A. J. Mohanty, S. Meagher, A. D. Khan, S. H. Boustani, M. A. Khan, B. A. | Sci Rep | 2022 |
Activities of Daily Living |
Risk factors for postoperative delirium on oxygen delivery-guided perfusion | Mukaida, H. Matsushita, S. Minami, Y. Sato, G. Usuba, M. Kondo, R. Asai, T. Amano, A. | J Cardiothorac Surg | 2022 |
Cardiopulmonary Bypass/adverse effects/methods |
Identifying Medicare Beneficiaries With Delirium | Moura, Lmvr Zafar, S. Benson, N. M. Festa, N. Price, M. Donahue, M. A. Normand, S. L. Newhouse, J. P. Blacker, D. Hsu, J. | Med Care | 2022 | |
The development of a web-based app employing machine learning for delirium prevention in long-term care facilities in South Korea | Moon, K. J. Son, C. S. Lee, J. H. Park, M. | BMC Med Inform Decis Mak | 2022 |
*Delirium/diagnosis/prevention & control |
Impact of Family Presence on Delirium in Critically Ill Patients: A Retrospective Cohort Study | Mohsen, S. Moss, S. J. Lucini, F. Krewulak, K. D. Stelfox, H. T. Niven, D. J. Sauro, K. M. Fiest, K. M. | Crit Care Med | 2022 | |
Serum levels of apolipoprotein A-I and E are associated with postoperative delirium: A post hoc analysis | Mietani, K. Hasegawa-Moriyama, M. Inoue, R. Ogata, T. Shimojo, N. Kurano, M. Yatomi, Y. Uchida, K. Sumitani, M. | Medicine (Baltimore) | 2022 |
Aged |
Staff training and the use of rapid, accurate and user-friendly tools for delirium screening could improve the diagnosis of delirium in the elderly referred to the emergency department | Mazzola, P. Spedale, V. | Evid Based Nurs | 2022 |
evidence-based nursing |
Current practice of pharmacological treatment for hyperactive delirium in terminally ill cancer patients: results of a nationwide survey of Japanese palliative care physicians and liaison psychiatrists | Matsuda, Y. Morita, T. Oya, K. Tagami, K. Naito, A. S. Kashiwagi, H. Otani, H. | Jpn J Clin Oncol | 2022 |
*Antipsychotic Agents/therapeutic use |
Higher serum PGE2 is a predicative biomarker for postoperative delirium following elective orthopedic surgery in elderly patients | Mao, M. Wang, L. Y. Zhu, L. Y. Wang, F. Ding, Y. Tong, J. H. Sun, J. Sun, Q. Ji, M. H. | BMC Geriatr | 2022 |
Aged |
Effect of acute pain on the association between preoperative cognitive impairment and postoperative delirium: a secondary analysis of three trials | Ma, J. H. Liu, Y. F. Hong, H. Li, C. J. Cui, F. Mu, D. L. Wang, D. X. | Br J Anaesth | 2022 |
cognitive dysfunction |
A systematic review of modified electroconvulsive therapy (ECT) to treat delirium | Lupke, K. Warren, N. Teodorczuk, A. Steele, S. Kolur, U. Wand, A. Robinson, G. Parker, S. | Acta Psychiatr Scand | 2022 |
acute confusion |
Incidence and interaction factors of delirium as an independent risk of mortality in elderly patients in the intensive units: a retrospective analysis from MIMIC-IV database | Liu, H. Zhao, Q. Liu, X. Hu, X. Wang, L. Zhou, F. | Aging Clin Exp Res | 2022 |
Delirium |
The effect of neostigmine on postoperative delirium after colon carcinoma surgery: a randomized, double-blind, controlled trial | Liu, F. Lin, X. Lin, Y. Deng, X. Guo, Y. Wang, B. Dong, R. Bi, Y. | BMC Anesthesiol | 2022 |
Adult |
Outcomes of postoperative delirium in patients undergoing cardiac surgery: A systematic review and meta-analysis | Lin, L. Zhang, X. Xu, S. Peng, Y. Li, S. Huang, X. Chen, L. Lin, Y. | Front Cardiovasc Med | 2022 |
cardiac surgery |
Non-pharmacological delirium prevention practices among critical care nurses: a qualitative study | Liang, S. Chau, J. P. C. Lo, S. H. S. Zhao, J. Liu, W. | BMC Nurs | 2022 |
Delirium |
Effect of regional anesthesia on the postoperative delirium: A systematic review and meta-analysis of randomized controlled trials | Li, T. Dong, T. Cui, Y. Meng, X. Dai, Z. | Front Surg | 2022 |
delirium |
Assessing Delirium at Hospital Discharge | Lepkowsky, C. M. Janklow, H. M. | Am J Geriatr Psychiatry | 2022 |
Delirium |
The Effects of Pain, Agitation, Delirium, Immobility, and Sleep Disruption Education on Novice Nurses in Adult Intensive Care Units | Lee, S. Y. Liu, C. Y. Wu, T. Y. | Healthcare (Basel) | 2022 |
Padis |
Treatment of Positive Urine Cultures at End-of-Life and the Effect on Terminal Delirium Management | Latuga, N. M. Grant, P. C. Levy, K. Luczkiewicz, D. L. | Am J Hosp Palliat Care | 2022 |
Anti-Bacterial Agents/therapeutic use |
Risk factors and effect of postoperative delirium on adverse surgical outcomes in older adults after elective abdominal cancer surgery in Taiwan | Lai, C. C. Liu, K. H. Tsai, C. Y. Hsu, J. T. Hsueh, S. W. Hung, C. Y. Chou, W. C. | Asian J Surg | 2022 |
Cancer surgery |
A Quality Improvement Study on Delirium Awareness Day: In Pursuit of Missed Delirium Diagnoses | Koca, M. Öztürk, Y. Boğa, İ Bürkük, S. Eşme, M. Akyürek, Y. Şimşek, S. Aydın, D. D. Çiçek, F. Karabulut, E. Halil, M. Cankurtaran, M. Tanrıöver, M. D. Doğu, B. B. | J Gerontol Nurs | 2022 |
Aged |
Serum C-reactive protein adds predictive information for post-stroke delirium: The PROPOLIS study | Klimiec-Moskal, E. Slowik, A. Dziedzic, T. | Acta Psychiatr Scand | 2022 |
Crp |
External validation and comparison of two delirium prediction models in patients admitted to the cardiac intensive care unit | Kim, S. E. Ko, R. E. Na, S. J. Chung, C. R. Choi, K. H. Kim, D. Park, T. K. Lee, J. M. Song, Y. B. Choi, J. O. Hahn, J. Y. Choi, S. H. Gwon, H. C. Yang, J. H. | Front Cardiovasc Med | 2022 |
Early PREdiction of DELIRium |
Delirium and Cortical Complexity | Kim, H. Lee, U. C. Vlisides, P. E. | Delirium and Cortical Complexity | 2022 | |
Can Variables From the Electronic Health Record Identify Delirium at Bedside? | Khan, A. Heslin, K. Simpson, M. Malone, M. L. | J Patient Cent Res Rev | 2022 |
delirium |
Thoracic Paravertebral Block Ameliorates Postoperative Delirium in Geriatric Patients | Heng, L. Wang, M. Wang, M. Li, L. Zhu, S. | Thorac Cardiovasc Surg | 2022 |
Aged |
Relationship of sleep disturbance and postoperative delirium: a systematic review and meta-analysis | He, E. Dong, Y. Jia, H. Yu, L. | Gland Surg | 2022 |
Postoperative delirium (PD) |
Acceptability of transdermal antipsychotic patches by patients who refuse oral medication and their effectiveness in preventing recurrence of delirium: a retrospective observational study | Hatta, K. Usui, C. Nakamura, H. | Int Clin Psychopharmacol | 2022 | |
Perioperative Hemodynamic Optimization in Patients at Risk for Delirium - A Randomized-Controlled Trial | Fuest, K. E. Servatius, A. Ulm, B. Schaller, S. J. Jungwirth, B. Blobner, M. Schmid, S. | Front Med (Lausanne) | 2022 |
frailty |
Proposing a Scientific and Technological Approach to the Summaries of Clinical Issues of Inpatient Elderly with Delirium: A Viewpoint | Frisardi, V. Nicolini, M. Cautero, N. Ghirardelli, R. Davolio, F. Haouili, M. Barani, M. | Healthcare (Basel) | 2022 |
delirium |
Incidence of Drug-Induced Delirium During Treatment With Antidepressants or Antipsychotics: A Drug Surveillance Report of German-Speaking Countries Between 1993 and 2016 | Friedrich, M. E. Grohmann, R. Rabl, U. Winkler, D. Konstantinidis, A. Engel, R. Seifert, J. Toto, S. Stübner, S. Frey, R. Kasper, S. | Int J Neuropsychopharmacol | 2022 |
Adverse Drug Reaction Reporting Systems |
The inter-relationship between delirium and dementia: the importance of delirium prevention | Fong, T. G. Inouye, S. K. | Nat Rev Neurol | 2022 | |
Five-Year Outcomes After Implementing a Pain, Agitation, and Delirium Protocol in a Mixed Intensive Care Unit | Fish, J. T. Baxa, J. T. Draheim, R. R. Willenborg, M. J. Mills, J. C. Sticht, L. A. Hankwitz, J. L. Wells, J. A. Jung, H. S. | J Intensive Care Med | 2022 |
Adult |
Improving Delirium Assessments in Vanderbilt Pediatric and Pediatric Cardiovascular Intensive Care Units | Eken, H. N. Betters, K. A. Fuchs, D. C. Smith, H. A. B. Williams, S. R. | Pediatr Qual Saf | 2022 | |
Outcomes in Post-operative Delirium Following Bowel Resection: A Single Center Retrospective Review | Desrochers, R. M. Lynch, L. J. Gates, J. D. Ricaurte, D. Wade, J. T. Dicks, R. S. Keating, J. J. | J Surg Res | 2022 |
Bowel |
Efficacy and Safety of Remimazolam Besylate versus Dexmedetomidine for Sedation in Non-Intubated Older Patients with Agitated Delirium After Orthopedic Surgery: A Randomized Controlled Trial | Deng, Y. Qin, Z. Wu, Q. Liu, L. Yang, X. Ju, X. Zhang, Y. Liu, L. | Drug Des Devel Ther | 2022 |
Benzodiazepines |
Delirium, changes in cognitive function, and risk of diagnosed dementia after kidney transplantation | Chu, N. M. Bae, S. Chen, X. Ruck, J. Gross, A. L. Albert, M. Neufeld, K. J. Segev, D. L. McAdams-DeMarco, M. A. | Am J Transplant | 2022 |
clinical research/practice |
Bispectral Index (BIS) Monitoring and Postoperative Delirium in Elderly Patients Undergoing Surgery: A Systematic Review and Meta-Analysis With Trial Sequential Analysis | Chew, W. Z. Teoh, W. Y. Sivanesan, N. Loh, P. S. Shariffuddin,, II Ti, L. K. Ng, K. T. | J Cardiothorac Vasc Anesth | 2022 |
Bis |
Delirium prevalence in geriatric emergency department patients: A systematic review and meta-analysis | Chen, F. Liu, L. Wang, Y. Liu, Y. Fan, L. Chi, J. | Am J Emerg Med | 2022 |
Aged |
Improving quantification of anticholinergic burden using the Anticholinergic Effect on Cognition Scale - a healthcare improvement study in a geriatric ward setting | Balasundaram, B. Ang, W. S. T. Stewart, R. Bishara, D. Ooi, C. H. Li, F. Akram, F. Eu Kwek, A. B. | Australas Psychiatry | 2022 |
Aged |
The Association of Selective Serotonin Reuptake Inhibitors With Delirium in Critically Ill Adults: A Secondary Analysis of the Bringing to Light the Risk Factors and Incidence of Neuropsychologic Dysfunction in ICU Survivors ICU Study | Austin, C. A. Yi, J. Lin, F. C. Pandharipande, P. Ely, E. W. Busby-Whitehead, J. Carson, S. S. | Crit Care Explor | 2022 |
delirium |
Parental Education and Delirium Risk after Surgery in Older Adults | Arias, F. Chen, F. Shiff, H. Marcantonio, E. R. Jones, R. N. Schmitt, E. M. Metzger, E. Fong, T. G. Travison, T. G. Inouye, S. K. | Clin Gerontol | 2022 |
Childhood socioeconomic status |
Informing the standardising of care for prolonged stay patients in the ICU: A scoping review of quality improvement tools | Allum, L. Apps, C. Pattison, N. Connolly, B. Rose, L. | Intensive Crit Care Nurs | 2022 |
Bundle |
Monitoring of nighttime EEG slow-wave activity during dexmedetomidine infusion in patients with hyperactive ICU delirium: An observational pilot study | Ala-Kokko, T. Erikson, K. Koskenkari, J. Laurila, J. Kortelainen, J. | Acta Anaesthesiol Scand | 2022 |
C-trend |
Development of a Delirium Risk Predication Model among ICU Patients in Oman | Al-Hoodar, R. K. Lazarus, E. R. Alomari, O. Alzaabi, O. | Anesthesiol Res Pract | 2022 | |
Comparison Between Deltascan Single Channel Electroencephalography (EEG), Confusion Assessment Method-Intensive Care Unit (CAM-ICU) Score and Clinical Assessment in Diagnosing Delirium in Intubated Patients in the Intensive Care Unit | Aben, J. Pouwels, S. Oldenbeuving, A. | Cureus | 2022 |
cam-icu |
A Cross-Sectional Survey on the Clinical Management of Emergence Delirium in Adults: Knowledge, Attitudes, and Practice in Mainland China | Yuan, Y. Lei, B. Li, Z. Wang, X. Zhao, H. Gao, M. Xue, Y. Zhang, W. Xiao, R. Meng, X. Zheng, H. Zhang, J. Wang, G. Guo, X. | Brain Sci | 2022 |
Pacu |
Development and Validation of a Nomogram for Predicting Postoperative Delirium in Patients With Elderly Hip Fracture Based on Data Collected on Admission | Yang, Y. Wang, T. Guo, H. Sun, Y. Cao, J. Xu, P. Cai, Y. | Front Aging Neurosci | 2022 |
albumin |
Preoperative Inflammatory Markers and the Risk of Postoperative Delirium in Patients Undergoing Lumbar Spinal Fusion Surgery | Yang, J. S. Lee, J. J. Kwon, Y. S. Kim, J. H. Sohn, J. H. | J Clin Med | 2022 |
CRP-to-albumin ratio |
An association between cancer type and delirium incidence in Japanese elderly patients: A retrospective longitudinal study | Yamato, K. Ikeda, A. Endo, M. Filomeno, R. Kiyohara, K. Inada, K. Nishimura, K. Tanigawa, T. | Cancer Med | 2022 |
cancer |
Increased Direct Current-Electroencephalography Shifts During Induction of Anesthesia in Elderly Patients Developing Postoperative Delirium | Windmann, V. Dreier, J. P. Major, S. Spies, C. Lachmann, G. Koch, S. | Front Aging Neurosci | 2022 |
*dc-eeg |
Risk factors of delirium after gastrointestinal surgery: A meta-analysis | Wang, X. Yu, D. Du, Y. Geng, J. | J Clin Nurs | 2022 |
delirium |
Physician Experience Design (PXD): More Usable Machine Learning Prediction for Clinical Decision Making | Wang, L. Chignell, M. Zhang, Y. Pinto, A. Razak, F. Sheehan, K. Verma, A. | AMIA Annu Symp Proc | 2022 |
Artificial Intelligence |
The Relationship Between Cardiovascular Disease Risk Score and Postoperative Delirium: The PNDABLE Study | Wang, J. Wang, L. Tang, X. Wang, F. Liu, S. Wu, X. Dong, R. Lin, X. Wang, B. Bi, Y. | Front Aging Neurosci | 2022 |
biomarkers |
Preoperative intervention to prevent delirium in patients with hip fracture - a systematic review | Virsøe-Frandsen, C. D. Skjold, C. Wildgaard, K. Møller, A. M. | Dan Med J | 2022 |
Aged |
Coexisting delirium and excited catatonia | Vellanki, K. D. Carroll, B. T. | Ann Clin Psychiatry | 2022 |
*Antipsychotic Agents/therapeutic use |
Confusion regarding the use of Natural Language Processing in ICU delirium assessment | van Diem-Zaal, I. J. van den Boogaard, M. Kotfis, K. Ely, E. W. | Intensive Care Med | 2022 |
*Delirium/diagnosis |
Postoperative delirium and changes in the blood-brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study | Taylor, J. Parker, M. Casey, C. P. Tanabe, S. Kunkel, D. Rivera, C. Zetterberg, H. Blennow, K. Pearce, R. A. Lennertz, R. C. Sanders, R. D. | Br J Anaesth | 2022 |
Biomarkers |
Prospective clinical intervention study of aripiprazole and risperidone in the management of postoperative delirium in elderly patients after cardiovascular surgery | Sugawara, H. Koyama, A. Maruyama, T. Koda, Y. Fukunaga, H. Ishikawa, T. Takebayashi, M. Okamoto, K. Fukui, T. Hashimoto, M. | Psychiatry Clin Neurosci | 2022 | |
A simple risk score list can be used to predict the occurrence of delirium in patients admitted to inpatient hospice care: A medical record study | Stoevelaar, R. Juffermans, C. C. M. Roorda, I. M. M. de Nijs, E. J. M. Hoornweg, J. Cannegieter, S. C. van der Linden, Y. M. | Eur J Cancer Care (Engl) | 2022 |
delirium |
Chemokines in ICU Delirium: An Exploratory Study | Smith, R. J. Rabinstein, A. A. Cartin-Ceba, R. Singh, V. P. Lachner, C. Khatua, B. Trivedi, S. Gajic, O. | Crit Care Explor | 2022 |
chemokine |
Cytokine profiles in intensive care unit delirium | Smith, R. J. Lachner, C. Singh, V. P. Trivedi, S. Khatua, B. Cartin-Ceba, R. | Acute Crit Care | 2022 |
cytokine |
Edmonton frailty scale score predicts postoperative delirium: a retrospective cohort analysis | Sieber, F. Gearhart, S. Bettick, D. Wang, N. Y | BMC Geriatr | 2022 |
Cohort Studies |
Observation of Anesthetic Effect of Dexmedetomidine Combined With Intraspinal Anesthesia in Hip Arthroplasty and its Effect on Postoperative Delirium and Stress Response | Shen, Y. Wang, C. Zhong, X. Wu, Y. He, X. | Front Surg | 2022 |
anesthetic effects |
Postoperative Application of Dexmedetomidine is the Optimal Strategy to Reduce the Incidence of Postoperative Delirium After Cardiac Surgery: A Network Meta-Analysis of Randomized Controlled Trials | Shang, L. Hou, M. Guo, F. | Ann Pharmacother | 2022 |
cardiac surgery |
Decreasing delirium through music listening (DDM) in critically ill, mechanically ventilated older adults in the intensive care unit: a two-arm, parallel-group, randomized clinical trial | Seyffert, S. Moiz, S. Coghlan, M. Balozian, P. Nasser, J. Rached, E. A. Jamil, Y. Naqvi, K. Rawlings, L. Perkins, A. J. Gao, S. Hunter, J. D., 3rd Khan, S. Heiderscheit, A. Chlan, L. L. Khan, B. | Trials | 2022 |
Aged |
Prevention of delirium with agitation by yokukansan in older adults after cancer surgery | Sadahiro, R. Wada, S. Matsuoka, Y. J. Uchitomi, Y. Yamaguchi, T. Sato, T. Esaki, M. Yoshimoto, S. Daiko, H. Kanemitsu, Y. Kawai, A. Kato, T. Fujimoto, H. Uezono, Y. Shimizu, K. Matsuoka, H. | Jpn J Clin Oncol | 2022 |
clinical trial |
Midazolam impacts acetyl-And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium? | Rump, K. Holtkamp, C. Bergmann, L. Nowak, H. Unterberg, M. Orlowski, J. Thon, P. Bazzi, Z. Bazzi, M. Adamzik, M. Koos, B. Rahmel, T. | PLoS One | 2022 |
Acetylcholinesterase/metabolism |
Ren, X. Zhang, S. Yang, Y. Song, A. Liang, F. Zhang, Y. Dong, Y. Wu, X. Xie, Z. | Ketamine Induces Delirium-Like Behavior and Interferes With Endosomal Tau Trafficking | Anesth Analg | 2022 | |
The crucial factors influencing the development and outcomes of postoperative delirium in proximal femur fractures | Rajeev, A. Railton, C. Devalia, K. | Aging Med (Milton) | 2022 |
delirium |
Neuromonitoring depth of anesthesia and its association with postoperative delirium | Pérez-Otal, B. Aragón-Benedí, C. Pascual-Bellosta, A. Ortega-Lucea, S. Martínez-Ubieto, J. Ramírez-Rodríguez, J. M. | Sci Rep | 2022 |
Anesthesia, General/adverse effects |
Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): protocol for a co-design and feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care | Pearson, M. Jackson, G. Jackson, C. Boland, J. Featherstone, I. Huang, C. Ogden, M. Sartain, K. Siddiqi, N. Twiddy, M. Johnson, M. | BMJ Open | 2022 |
*Delirium/diagnosis/prevention & control |
An Interdisciplinary Reappraisal of Delirium and Proposed Subtypes | Oldham, M. A. Slooter, A. J. C. Ely, E. W. Crone, C. Maldonado, J. R. Rosenthal, L. J. | J Acad Consult Liaison Psychiatry | 2022 |
acute encephalopathy |
Postoperative Delirium in Patients with Oral Cancer: Is Intraoperative Fluid Administration a Neglected Risk Factor? | Obermeier, K. T. Kraus, M. Smolka, W. Henkel, J. Saller, T. Otto, S. Liokatis, P. | Cancers (Basel) | 2022 |
fluid balance |
Risk of delirium associated with antimuscarinics in older adults: A case-time-control study | Nishtala, P. S. Chyou, T. Y. | Pharmacoepidemiol Drug Saf | 2022 |
Aged |
Potential effects of regular use of antihypertensive drugs for in-hospital delirium in geriatric patients with trauma | Nagasawa, H. Omori, K. Ota, S. Muramatsu, K. I. Ishikawa, K. Yanagawa, Y. | Sci Rep | 2022 |
Aged |
Performance of Melatonin as Prophylaxis in Geriatric Patients with Multifactorial Risk for Postoperative Delirium Development: A Randomized Comparative Study | Mohamed, S. A. Rady, A. Youssry, M. Abdelaziz Mohamed, M. R. Gamal, M. | Turk J Anaesthesiol Reanim | 2022 | |
Perioperative risk factors associated with increased incidence of postoperative delirium: systematic review, meta-analysis, and Grading of Recommendations Assessment, Development, and Evaluation system report of clinical literature | Mevorach, L. Forookhi, A. Farcomeni, A. Romagnoli, S. Bilotta, F. | Br J Anaesth | 2022 |
Grade |
Delirium in ICU Patients after Cardiac Arrest: A Scoping Review | Mędrzycka-Dąbrowska, W. Lange, S. Religa, D. Dąbrowski, S. Friganović, A. Oomen, B. Krupa, S. | J Pers Med | 2022 |
Icu |
Epidemiology of delirium in hospitalized patients in Latin America: A systematic review | Maximiliano, B. Sebastian, B. Estefania, A. Irma, C. Gutierrez, P. Daniela, P. Pv Roberta, C. Eduardo, T. Jose, M. Felipe, S. | Acta Psychiatr Scand | 2022 |
Latin America |
Effect of Perioperative Dexmedetomidine Infusion on Postoperative Delirium in Elderly Patients Undergoing Oral and Maxillofacial Surgery: A Randomized Controlled Clinical Trial | Liu, T. Tuo, J. Wei, Q. Sun, X. Zhao, H. Zhao, X. Qu, M. | Int J Gen Med | 2022 |
dexmedetomidine |
Type 2 Diabetes Mellitus with Tight Glucose Control and Poor Pre-Injury Stair Climbing Capacity May Predict Postoperative Delirium: A Secondary Analysis | Liu, K. Song, Y. Yuan, Y. Li, Z. Wang, X. Zhang, W. Li, Y. Mi, X. Han, D. Rong, Y. Guo, X. Wang, G. | Brain Sci | 2022 |
glycemic control |
Preoperative Plasma Tau-PT217 and Tau-PT181 Are Associated With Postoperative Delirium | Liang, F. Baldyga, K. Quan, Q. Khatri, A. Choi, S. Wiener-Kronish, J. Akeju, O. Westover, B. M. Cody, K. Shen, Y. Marcantonio, E. R. Xie, Z. | Ann Surg | 2022 | |
Development and Validation of Simplified Delirium Prediction Model in Intensive Care Unit | Kim, M. K. Oh, J. Kim, J. J. Park, J. Y. | Front Psychiatry | 2022 |
critical care |
The effects of hypomagnesemia on delirium in middle-aged and older adult patients admitted to medical intensive care units | Kim, J. Y. Lee, H. J. Lee, H. Y. Lee, S. M. Lee, J. Park, T. Y. | Acute Crit Care | 2022 |
delirium |
Structural integrity of the anterior mid-cingulate cortex contributes to resilience to delirium in SuperAging | Katsumi, Y. Wong, B. Cavallari, M. Fong, T. G. Alsop, D. C. Andreano, J. M. Carvalho, N. Brickhouse, M. Jones, R. Libermann, T. A. Marcantonio, E. R. Schmitt, E. Shafi, M. M. Pascual-Leone, A. Travison, T. Barrett, L. F. Inouye, S. K. Dickerson, B. C. Tou | Brain Commun | 2022 |
Mri |
"Excited delirium," erroneous concepts, dehumanizing language, false narratives, and threat to Black lives | Fiscella, K. Pinals, D. A. Shields, C. G. | Acad Emerg Med | 2022 |
*Delirium/diagnosis |
Knowing the Older Adult With Delirium Superimposed on Dementia | Fick, D. M. | Am J Geriatr Psychiatry | 2022 |
Delirium |
Bibliometric Analysis of 100 Most-Cited Articles in Delirium | Fei, X. Zeng, Q. Wang, J. Gao, Y. Xu, F. | Front Psychiatry | 2022 |
bibliometric analysis |
Transcutaneous Electrical Acupoint Stimulation Combined With Auricular Acupressure Reduces Postoperative Delirium Among Elderly Patients Following Major Abdominal Surgery: A Randomized Clinical Trial | Fan, Q. Lei, C. Wang, Y. Yu, N. Wang, L. Fu, J. Dong, H. Lu, Z. Xiong, L. | Front Med (Lausanne) | 2022 |
abdominal surgery |
Depression is associated with delirium after cardiac surgery-a population-based cohort study | Falk, A. Kåhlin, J. Nymark, C. Hultgren, R. Stenman, M. | Interact Cardiovasc Thorac Surg | 2022 |
Aged |
Association of delirium screening on hospitalized adults and postacute care utilization: A retrospective cohort study | Dulin, J. D. Zhang, J. Marsden, J. Mauldin, P. D. Moran, W. P. Kalivas, B. C. | Am J Med Sci | 2022 | |
Adaptation, implementation, and mixed methods evaluation of an interprofessional modular clinical practice guideline for delirium management on an inpatient palliative care unit | Bush, S. H. Skinner, E. Lawlor, P. G. Dhuper, M. Grassau, P. A. Pereira, J. L. MacDonald, A. R. Parsons, H. A. Kabir, M. | BMC Palliat Care | 2022 |
Adult |
Older age, delirium, dementia, frailty, and critical care: Care priorities | Bloomer, M. J. Woszczeiko, C. Hutchinson, A. M. | Intensive Crit Care Nurs | 2002 |
Critical care |
Early Diagnosis of Delirium in Palliative Care Patients Decreases Mortality and Necessity of Palliative Sedation: Results of a Prospective Observational Study | Beretta, M. Uggeri, S. Santucci, C. Cattaneo, M. Ermolli, D. Gerosa, C. Ornaghi, M. Roccasalva, A. Santambrogio, P. Varrassi, G. Corli, O. | Cureus | 2022 |
clinical outcome |
Incidence and associations of hospital delirium diagnoses in 85,979 people with severe mental illness: A data linkage study | Bauernfreund, Y. Launders, N. Favarato, G. Hayes, J. F. Osborn, D. Sampson, E. L. | Acta Psychiatr Scand | 2022 |
bipolar disorder |
The Pharmacogenetics of Opiates and Its Impact on Delirium in Mechanically Ventilated Adults: A Pilot Study | Austin, C. A. Szeto, A. Gupta, A. Wiltshire, T. Crona, D. J. Kistler, C. | J Pharm Technol | 2022 |
analgesics |