What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Development and Validation of a Routine Electronic Health Record-Based Delirium Prediction Model for Surgical Patients Without Dementia: Retrospective Case-Control Study | Holler, E. Ludema, C. Ben Miled, Z. Rosenberg, M. Kalbaugh, C. Boustani, M. Mohanty, S. | JMIR Perioper Med | 2025 |
Humans *Electronic Health Records/statistics & numerical data Female Male Aged Retrospective Studies *Delirium/diagnosis/epidemiology/etiology Case-Control Studies Middle Aged *Postoperative Complications/epidemiology/diagnosis/etiology Dementia/epidemiology/diagnosis Risk Assessment/methods Indiana/epidemiology Aged, 80 and over Machine Learning Predictive Value of Tests algorithm delirium electronic health records postoperative prediction risk prediction surgery |
| Multivariable Predictive Model of Postoperative Delirium in Cardiac Surgery Patients: Proteomic and Demographic Contributions | Gonçalves, M. C. B. Khera, T. Otu, H. H. Narayanan, S. Dillon, S. T. Shanker, A. Gu, X. Jung, Y. Ngo, L. H. Marcantonio, E. R. Libermann, T. A. Subramaniam, B. | Anesth Analg | 2025 |
Humans Male Female Aged *Cardiac Surgical Procedures/adverse effects *Proteomics/methods *Biomarkers/blood *Predictive Value of Tests Risk Factors Delirium/blood/diagnosis/etiology Middle Aged Multivariate Analysis Risk Assessment Aged, 80 and over Postoperative Complications/diagnosis/blood/etiology Prospective Studies |
| Outcomes of a delirium prevention program after major abdominal emergency surgery: An interventional study | Finne, K. F. Thorup, T. Skovsen, A. P. G. Tolstrup, M. B. | World J Surg | 2025 |
Humans Male Female Aged *Delirium/prevention & control/etiology *Postoperative Complications/prevention & control/epidemiology Aged, 80 and over Length of Stay/statistics & numerical data Treatment Outcome Emergencies Abdomen/surgery emergency surgery major abdominal surgery postoperative delirium |
| Incidence and risk factors of postoperative delirium in elderly surgical patients 2023 | Fenta, E. Teshome, D. Kibret, S. Hunie, M. Tiruneh, A. Belete, A. Molla, A. Dessie, B. Geta, K. | Sci Rep | 2025 |
Aged Aged, 80 and over Female Humans Male Middle Aged Delirium/epidemiology/etiology *Emergence Delirium/epidemiology/etiology Ethiopia/epidemiology Incidence *Postoperative Complications/epidemiology/etiology Prevalence Risk Factors Elderly patients Nursing delirium screening scale Post anesthesia care unit Postoperative delirium |
| Association Between Blood Urea Nitrogen and Delirium in Critically Ill Elderly Patients Without Kidney Diseases: A Retrospective Study and Mendelian Randomization Analysis | Fang, Y. Tang, X. Gao, Y. Xie, H. Shen, Y. Peng, M. Liu, J. Zhang, Y. Cui, Y. Xie, K. | CNS Neurosci Ther | 2025 |
Humans *Mendelian Randomization Analysis *Critical Illness Retrospective Studies Aged *Delirium/blood/epidemiology/genetics/diagnosis Male Female *Blood Urea Nitrogen Aged, 80 and over Risk Factors Icu‐cam Mimic iv delirium elderly encephalopathy mendelian randomization urea nitrogen |
| Machine Learning-Based Prediction of Delirium and Risk Factor Identification in ICU Patients with Burns: A Retrospective Observational Study | Esumi, R. Funao, H. Kawamoto, E. Sakamoto, R. Ito-Masui, A. Okuno, F. Shinkai, T. Hane, A. Ikejiri, K. Akama, Y. Gaowa, A. Park, E. J. Momosaki, R. Kaku, R. Shimaoka, M. | JMIR Form Res | 2025 |
Delirium, ICU, Burn care, Machine learning model, ICU delirium screening checklist |
| Influence of Intraoperative Pain Management on Postoperative Delirium in Elderly Patients: A Prospective Single-Center Randomized Controlled Trial | Du, Y. Cao, J. Gao, C. He, K. Wang, S. | Pain Ther | 2025 |
Analgesia pain Geriatric anesthesia Pain management Postoperative delirium |
| Prevalence of delirium in German nursing homes: protocol for a cross-sectional study | Dörner, J. Houdelet-Oertel, A. Arslan, Z. Lauer, R. Otte, I. Vollmar, H. C. Thürmann, P. Palm, R. Holle, B. | BMJ Open | 2025 |
Humans *Nursing Homes/statistics & numerical data Germany/epidemiology Cross-Sectional Studies Prevalence *Delirium/epidemiology/diagnosis Aged Male Homes for the Aged/statistics & numerical data Female Research Design Aged, 80 and over Delirium & cognitive disorders Epidemiologic studies Geriatric medicine |
| Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium | Denver, P. Tortorelli, L. Hov, K. Berg, J. P. Giil, L. M. Nazmi, A. Lopez-Rodriguez, A. Healy, D. Murray, C. Barry, R. Watne, L. O. Cunningham, C. | Brain Behav Immun Health | 2025 |
Blood CSF barrier Blood brain barrier Ccl11 Csf Chemokines Delirium Mip1α Systemic inflammation |
| Delirium at the intensive care unit and long-term survival: a retrospective study | De Trizio, I. Komninou, M. A. Ernst, J. Schüpbach, R. Bartussek, J. Brandi, G. | BMC Neurol | 2025 |
Humans Retrospective Studies *Intensive Care Units/statistics & numerical data Middle Aged *Delirium/mortality/epidemiology/diagnosis Male Female Aged Switzerland/epidemiology Adult Survivors/statistics & numerical data Delirium Encephalopathy Icu Long-term survival |
| Dose-response analysis of music intervention for improving delirium in intensive care unit patients: A systematic review and meta-analysis | Dai, R. S. Wang, T. H. Chien, S. Y. Tzeng, Y. L. | Nurs Crit Care | 2025 |
delirium dose–response analysis intensive care unit (ICU) music therapy |
| Dose-response analysis of music intervention for improving delirium in intensive care unit patients: A systematic review and meta-analysis | Dai, R. S. Wang, T. H. Chien, S. Y. Tzeng, Y. L. | Nurs Crit Care | 2025 |
delirium dose–response analysis intensive care unit (ICU) music therapy |
| Dose-response analysis of music intervention for improving delirium in intensive care unit patients: A systematic review and meta-analysis | Dai, R. S. Wang, T. H. Chien, S. Y. Tzeng, Y. L. | Nurs Crit Care | 2025 |
delirium dose–response analysis intensive care unit (ICU) music therapy |
| Development of a LASSO machine learning algorithm-based model for postoperative delirium prediction in hepatectomy patients | Zhu, Y. Liang, R. Wang, Y. Yang, J. J. Zhou, N. Zhou, C. M. | BMC Surg | 2025 |
Humans *Hepatectomy/adverse effects Female Male *Machine Learning *Nomograms *Delirium/diagnosis/etiology/epidemiology *Postoperative Complications/diagnosis/epidemiology/etiology Middle Aged Aged Risk Factors Algorithms ROC Curve Hepatectomy Lasso Nomogram Pod Predicting |
| Ultrasound-guided femoral nerve block reduced the incidence of postoperative delirium after total knee arthroplasty: A double-blind, randomized study | Ultrasound-guided femoral nerve block reduced the incidence of postoperative delirium after total knee arthroplasty: A double-blind, randomized study | Medicine (Baltimore) | 2024 |
Humans *Arthroplasty, Replacement, Knee/adverse effects/methods Aged *Nerve Block/methods Male Female *Femoral Nerve Double-Blind Method *Ultrasonography, Interventional/methods Incidence *Pain, Postoperative/prevention & control/epidemiology/etiology Aged, 80 and over Delirium/prevention & control/etiology/epidemiology Postoperative Complications/prevention & control/epidemiology/etiology Pain Measurement |
| Preemptive hydromorphone analgesia reduces postoperative delirium and stress response in laparoscopic cholecystectomy patients | Zhang, W. Yang, Y. Yan, Y. | Am J Transl Res | 2024 |
Hydromorphone hydrochloride laparoscopic cholecystectomy postoperative delirium preemptive analgesia stress response |
| Evaluating the effectiveness of a clinical decision support system (AI-Antidelirium) to improve Nurses' adherence to delirium guidelines in the intensive care unit | Zhang, S. Ding, S. Cui, W. Li, X. Wei, J. Wu, Y. | Intensive Crit Care Nurs | 2025 |
Adherence Artificial intelligence Clinical Decision Supporting System Delirium Intensive care unit |
| The global research trends in perioperative cognitive function protection for preventing postoperative delirium: A bibliometric analysis | Zeng, Y. Yu, J. Zhang, J. Song, M. Gao, X. | J Clin Neurosci | 2025 |
Bibliometric Analysis Cognitive Function Global Trend Postoperative Delirium Visualized Analysis |
| Effectiveness of non-pharmacological intervention protocol for prevention of postoperative delirium in the surgical intensive care unit | Yuyen, T. Narksut, A. Lao-Amornphunkul, S. Thanakiattiwibun, C. Pansangar, C. Thikom, N. Chaiwat, O. Piriyapatsom, A. | Sci Rep | 2025 |
Humans Aged Male Female *Intensive Care Units *Delirium/prevention & control/epidemiology *Postoperative Complications/prevention & control/epidemiology Incidence Aged, 80 and over Treatment Outcome Delirium prevention Elderly patients Non-pharmacological intervention Postoperative delirium Prevention Surgical intensive care unit |
| Delirium after deep brain stimulation for Parkinson's disease: a meta-analysis of incidence and risk factors | Yousef, O. Abouelmagd, M. E. Abbas, A. Elrosasy, A. Shbani, A. Raslan, A. M. | Neurosurg Rev | 2025 |
Humans *Deep Brain Stimulation/adverse effects/methods *Parkinson Disease/therapy Risk Factors *Delirium/epidemiology/etiology Incidence Postoperative Complications/epidemiology Deep brain stimulation Delirium Parkinsonism Parkinson’s disease |
| Early Screening for Confusion and Vitamin D Deficiency in Elderly Hip Fracture Patients: A Quality Improvement Initiative to Mitigate the Risk of Postoperative Delirium | Younis, Z. Gurukiran, G. Abdullah, F. Kumar, S. Ford, D. Hamid, M. A. Wani, K. F. | Cureus | 2024 |
cognitive screening elderly patient care hip fracture management postoperative delirium vitamin d deficiency |
| Disproportionality analysis of amenamevir-induced encephalopathy using the Japanese adverse drug event report database | Yamada, T. Ogawa, T. Tanaka, T. Kusaka, Y. Nishihara, M. Ashida, A. | J Infect Chemother | 2025 |
Humans Female Male Retrospective Studies Aged Japan/epidemiology Middle Aged *Adverse Drug Reaction Reporting Systems/statistics & numerical data *Brain Diseases/chemically induced/epidemiology Risk Factors *Antiviral Agents/adverse effects Aged, 80 and over Databases, Factual/statistics & numerical data Herpes Zoster/epidemiology Adult East Asian People Adverse event Amenamevir Encephalopathy Pharmacovigilance |
| Cardiac surgery outcomes: The efficacy of dexmedetomidine in reducing postoperative delirium - A bibliometric study | Yabo, W. Dongxu, L. Xiao, L. Qi, A. | Curr Probl Cardiol | 2025 |
Cardiac surgery Cite space analysis Dexmedetomidine Postoperative delirium Visualized analysis α2-adrenoceptor |
| The impact of remimazolam compared to propofol on postoperative delirium: a systematic review and meta-analysis | Xue, X. Ma, X. Zhao, B. Liu, B. Zhang, J. Li, Z. Li, H. Liu, X. Zhao, S. | Minerva Anestesiol | 2025 |
Benzodiazepines, postoperative delirium, review, propofol, remimazolam |
| Impact of delirium on post-discharge mortality in coronary care unit patients: A retrospective cohort study | Xu, H. B. Shu, M. Wu, J. J. Li, R. F. Lin, X. H. Zhang, H. G. | Nurs Crit Care | 2025 |
coronary care unit delirium mortality survivors |
| Effects of Sensory-Based Interventions on Delirium Prevention in Critically Ill Patients: A Systematic Review and Meta-Analysis | Xu, C. Zhang, Y. Yuan, D. Wang, C. Wang, X. Liang, X. Wang, J. Duan, J. | Int J Nurs Pract | 2025 |
Humans *Delirium/prevention & control/epidemiology *Critical Illness Randomized Controlled Trials as Topic delirium intensive care meta‐analysis sensory‐based interventions |
| The association between the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio and delirium in ischemic stroke patients | Wang, P. Huang, J. Xu, L. Hu, R. | Front Med (Lausanne) | 2024 |
Mendelian randomization delirium inflammation ischemic stroke risk factor |
| Risk Factors and Pain Management in the Incidence of Postoperative Delirium in Elderly Patients: A Retrospective Study | Vizerie, L. Morales, T. Galey, S. Montel, F. Velly, L. Bruder, N. Simeone, P. | J Clin Med | 2024 |
pain management postoperative delirium postoperative pain risks factors surgery |
| Exploring factors influencing delirium incidence: Insights from the Alzira cohort study, 2012-2021 | Villalón-Rubio, D. García-Tercero, E. López-Gómez, J. González, H. Belenguer-Varea, Á Cunha-Pérez, C. Germán Borda, M. Tarazona-Santabalbina, F. J. | Rev Esp Geriatr Gerontol | 2025 |
Humans *Delirium/epidemiology Male Female Aged Aged, 80 and over *Hip Fractures/complications/epidemiology Hospitalization Incidence Retrospective Studies Risk Factors Spain/epidemiology Delirium Fractura de cadera Hip fracture Mortalidad Mortality |
| Can Neutrophil-to-Lymphocyte Ratio, Platelet Volume, and Platelet Distribution Width Be Used as Indicators of Delirium? | Tuncer, B. Çelik, F. Çelik, B. Erkılıç, E. | J Clin Med | 2024 |
children general anesthesia neutrophil/lymphocyte ratio postoperative delirium |
| The effect of type of anaesthetic on delirium after surgery for acute hip fracture: An instrumental variable analysis to assess causation | Tanios, A. G. Gallagher, E. L. McManus, M. S. Riordan, J. A. Harris, I. A. Harvey, L. A. | Anaesth Intensive Care | 2025 |
Anaesthesia Australia New Zealand conduction anaesthesia delirium general anaesthesia hip fractures multicentre studies registries retrospective studies |
| Incidence of Delirium during the Initiation Phase of Morphine and Hydromorphone Therapy in Cancer Patients: A Retrospective Comparative Study | Tanaka, H. Tanaka, R. Kamoshida, T. Morimoto, S. Sato, J. Ishikawa, H. Sato, T. Sato, T. Saitoh, A. Yamada, D. Kondo, M. Takahashi, K. Takahashi, C. Shino, M. | Can J Hosp Pharm | 2025 |
delirium hydromorphone morphine oral opioids |
| Intravenous dexmedetomidine for delirium prevention in elderly patients following orthopedic surgery: a meta-analysis of randomized controlled trials | Sun, J. Wang, D. Zhao, Y. Bai, Y. Wang, S. Meng, C. Miao, G. Liu, P. | BMC Pharmacol Toxicol | 2025 |
Humans *Dexmedetomidine/administration & dosage/therapeutic use *Randomized Controlled Trials as Topic *Orthopedic Procedures/adverse effects *Delirium/prevention & control Aged *Postoperative Complications/prevention & control Hypnotics and Sedatives/administration & dosage/therapeutic use Administration, Intravenous Delirium Dexmedetomidine Orthopedic surgery |
| Postoperative delirium under general anaesthesia by remimazolam versus propofol: A systematic review and meta-analysis of randomised controlled trials | Suga, M. Yasuhara, J. Watanabe, A. Takagi, H. Kuno, T. Nishimura, T. Ijuin, S. Taira, T. Inoue, A. Ishihara, S. Pakavakis, A. Glassford, N. Shehabi, Y. | J Clin Anesth | 2025 |
Humans *Propofol/adverse effects/administration & dosage *Anesthesia, General/adverse effects *Randomized Controlled Trials as Topic *Hypnotics and Sedatives/administration & dosage/adverse effects *Benzodiazepines/adverse effects/administration & dosage Incidence Emergence Delirium/prevention & control/epidemiology Delirium/epidemiology/prevention & control/chemically induced Hypotension/chemically induced/epidemiology Postoperative Complications/epidemiology/prevention & control Anesthetics, Intravenous/adverse effects/administration & dosage General anaesthesia Intraoperative hypotension Postoperative delirium (POD) Postoperative delirium and cognitive dysfunction (POCD) Propofol Remimazolam |
| Association between delirium severity and prognosis following Transcatheter aortic valve implantation | Suenaga, T. Ishizu, K. Shirai, S. Yoshida, S. Wakugawa, H. Miyahara, K. Yamamoto, K. Otani, A. Miyawaki, N. Nakano, K. Ko, E. Yoshino, Y. Tsuru, Y. Nakamura, M. Morofuji, T. Hayashi, M. Isotani, A. Ohno, N. Kakumoto, S. Ando, K. | J Cardiol | 2025 |
Delirium Frailty Prognosis Transcatheter aortic valve implantation |
| Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium: A Cluster Randomized Crossover Trial | Spence, J. Devereaux, P. J. Lee, S. F. D'Aragon, F. Avidan, M. S. Whitlock, R. P. Mazer, C. D. Rousseau-Saine, N. Rajamohan, R. R. Pryor, K. O. Klein, R. Tan, E. Cameron, M. J. Di Sante, E. DeBorba, E. Mustard, M. E. Couture, E. J. Zamper, R. P. C. Law, M | JAMA Surg | 2025 |
delirium, cardiac surgery, postoperative delirium, benzodiazepines |
| Protein alterations in patients with delirium after cardiac surgery: An exploratory case-control sub-study of the VISION Cardiac Surgery Biobank | Spence, J. Devereaux, P. J. Bashir, S. Brady, K. Sun, T. Chan, M. T. V. Wang, C. Y. Lamy, A. Whitlock, R. P. McIntyre, W. F. Belley-Côté, E. Paré, G. Chong, M. | Anesthesiology | 2025 |
Delirium, biomarkers, Postoperative delirium, Olink, Proteins |
| Prevention of Delirium in the Intensive Care Unit through Nonpharmacological Interventions: An Umbrella Review | Sonia, M. Kaur, S. Kothari, N. | Indian J Crit Care Med | 2025 |
Critical care Delirium Meta-analysis Nonpharmacological interventions Systematic review |
| Prioritization Patterns of Nurses in the Management of a Patient With Delirium: Results of a Q-Methodology Study | Sist, L. Pezzolati, M. Ugenti, N. V. Cedioli, S. Messina, R. Chiappinotto, S. Rucci, P. Palese, A. | Res Nurs Health | 2025 |
Q‐methodology delirium delirium/nursing management prioritization priority setting |
| Analysis of Delirium Risk Assessment Tools for Prediction of Postoperative Delirium Following Lumbar Spinal Fusion | Singh, M. Sahhar, M. Nassar, J. E. Farias, M. J. Rasquinha, R. Kim, J. Diebo, B. G. Daniels, A. H. | Spine (Phila Pa 1976) | 2025 |
Delirium Risk Assessment Score Delirium Risk Assessment Tool Delirium Elderly At-Risk Postoperative delirium Posterior lumbar fusion |
| The Presence/Absence of an Awake-State Dominant EEG Rhythm in Delirious Patients Is Related to Different Symptoms of Delirium Evaluated by the Intensive Care Delirium Screening Checklist (ICDSC) | Shinba, T. Fujita, Y. Ogawa, Y. Shinba, Y. Shinba, S. | Sensors (Basel) | 2024 |
Humans *Delirium/diagnosis/physiopathology *Electroencephalography/methods Male Female Aged Middle Aged *Wakefulness/physiology Checklist Aged, 80 and over Critical Care/methods Intensive Care Delirium Screening Checklist delirium dominant rhythm electroencephalography eyes opening and closing hallucination or delusion symptom fluctuation |
| Unveiling the Immune Landscape of Delirium through Single-Cell RNA Sequencing and Machine Learning: Towards Precision Diagnosis and Therapy | Shi, Y. Xu, P. | Psychogeriatrics | 2025 |
Humans *Machine Learning *Sequence Analysis, RNA/methods Male *Delirium/diagnosis/genetics Female Aged Biomarkers/blood Leukocytes, Mononuclear/metabolism/immunology Middle Aged Signal Transduction/genetics Single-Cell Analysis/methods Proto-Oncogene Proteins c-akt/genetics Postoperative Complications/diagnosis Case-Control Studies machine learning peripheral blood mononuclear cells postoperative delirium single‐cell RNA sequencing |
| Characterizing Difficulties and Management of Sleep Disturbances in a Tertiary Palliative Care Unit-A Retrospective Review | Schacter, J. Pilkey, J. | J Palliat Care | 2025 |
delirium insomnia palliative care pharmacotherapy sleep trends |
| The Correlation of Hemostatic Parameters with the Development of Early Sepsis-Associated Encephalopathy. A Retrospective Observational Study | Scarlatescu, F. Scarlatescu, E. Tomescu, D. R. Bartos, D. | J Crit Care Med (Targu Mures) | 2024 |
clot strength clotting platelets rotation thromboelastometry sepsis-associated encephalopathy |
| Identifying Challenges Related to the Management of Comorbidities in People with Dementia in Residential Care: Expert Delphi Consensus Exercise | Sabatini, S. Hawes, F. Eluigwe, K. Tang, E. Y. H. | J Appl Gerontol | 2025 |
Alzheimer’s care home co-morbidity health conditions multimorbidity nursing home |
| Navigating Dementia and Delirium: Balancing Identity and Interests in Advance Directives | Rutenkröger, M. | Nurs Philos | 2025 |
Humans *Dementia/psychology/nursing *Advance Directives/psychology/ethics *Delirium/psychology Decision Making/ethics advance directive delirium dementia identity moral authority self‐ownership |
| Delirium Among Liver Transplant Recipients: A National Analysis Using MarketScan | Ruck, J. M. Parra, M. A. Price, M. D. Hicks, C. W. King, E. A. | J Surg Res | 2025 |
Delirium Encephalopathy Hospitalization Liver Rehabilitation Transplantation |
| Ulinastatin treatment mitigates glycocalyx degradation and associated with lower postoperative delirium risk in patients undergoing cardiac surgery: a multicentre observational study | Ran, X. Xu, T. Liu, J. Yang, S. Luo, F. Wu, R. Tan, J. Ruan, H. Zhang, Q. | Crit Care | 2025 |
Humans *Glycocalyx/drug effects/metabolism Male Female Retrospective Studies Middle Aged *Cardiac Surgical Procedures/adverse effects/methods Aged *Delirium/prevention & control/etiology *Postoperative Complications/prevention & control/etiology Prospective Studies *Glycoproteins/therapeutic use/pharmacology Cohort Studies Cardiac surgery Critical care Glycocalyx degradation Mediation effect Postoperative delirium Ulinastatin |
| Barriers to healthcare professionals screening, recognizing, and managing delirium in the adult patients receiving specialist palliative care: a mixed-methods systematic review | Qian, F. Yao, D. Shi, H. Tung, T. H. Bi, D. | BMC Palliat Care | 2025 |
Humans *Delirium/diagnosis/therapy *Palliative Care/methods/standards *Health Personnel/psychology *Mass Screening/methods/standards Adult Delirium Healthcare professionals Management Palliative care Recognition Screening Systematic review |
| Sarcopenia is a risk factor for postoperative delirium in geriatric hip fracture patients: a retrospective study | Qi, Y. M. Li, H. T. Chang, S. M. Hu, S. J. Du, S. C. Liu, C. D. Chu, Y. Q. Rui, Y. F. | Front Med (Lausanne) | 2024 |
geriatric hip fracture postoperative delirium risk factor sarcopenia |
| Efficacy and safety of guanfacine in hospitalized patients with delirium: A scoping review | Pattamin, N. Phongphithakchai, A. Spano, S. Maeda, A. Chaba, A. Hikasa, Y. Bellomo, R. | Crit Care Resusc | 2024 |
Agitation Anesthesia and intensive care Delirium Guanfacine |
| Practices and attitudes of adult psychiatrists regarding methamphetamine-associated psychotic disorder: an internet based survey conducted in Turkey | Örüm, M. H. Kapıcı, Y. Sönmez, D. Tanrıkulu, A. B. Gümüşay, M. Koçhan, O. Örüm, D. Hocaoğlu, Ç | BMC Health Serv Res | 2025 |
Humans Turkey *Methamphetamine/adverse effects Adult Male Female *Internet *Attitude of Health Personnel *Psychiatry Practice Patterns, Physicians’/statistics & numerical data Surveys and Questionnaires Antipsychotic Agents/therapeutic use/adverse effects Middle Aged Psychotic Disorders/drug therapy Amphetamine-Related Disorders/psychology Psychiatrists Methamphetamine Prescription practice Psychosis Psychotropic preferences Psychotropic selection |
| Initial dose of tapentadol and concomitant use of duloxetine are associated with delirium occurring after initiation of tapentadol therapy in cancer patients | Nakamura, T. Miyamoto, T. Tanada, D. Nishii, R. Okamura, S. Inui, T. Doi, Y. Tanaka, K. Yanai, M. Hirose, M. Kimura, T. | J Opioid Manag | 2024 |
Humans *Tapentadol/administration & dosage/adverse effects Male Female Aged *Delirium/chemically induced/diagnosis Retrospective Studies Middle Aged *Analgesics, Opioid/adverse effects/administration & dosage *Duloxetine Hydrochloride/adverse effects/administration & dosage/therapeutic use *Neoplasms/drug therapy Cancer Pain/drug therapy Aged, 80 and over Japan/epidemiology Adult |
| Global prevalence and risk factors of delirium among patients following acute stroke: A systematic review and meta-analysis | Mukminin, M. A. Yeh, T. H. Lin, H. C. Rohmah, I. Chiu, H. Y. | J Stroke Cerebrovasc Dis | 2025 |
Humans Risk Factors Prevalence *Delirium/epidemiology/diagnosis/etiology *Stroke/epidemiology/diagnosis/complications Male Aged Female Risk Assessment Middle Aged Aged, 80 and over Observational Studies as Topic Prognosis Age Factors Adult Time Factors Global Health Acute stroke Delirium Meta-analysis Risk factor |
| Assessment of Geriatric Problems and Risk Factors for Delirium in Surgical Medicine: Protocol for Multidisciplinary Prospective Clinical Study | Möllmann, H. L. Alhammadi, E. Boulghoudan, S. Kuhlmann, J. Mevissen, A. Olbrich, P. Rahm, L. Frohnhofen, H. | JMIR Res Protoc | 2025 |
Humans *Delirium/diagnosis/epidemiology/etiology *Geriatric Assessment/methods Aged Risk Factors Prospective Studies Male Aged, 80 and over Female Postoperative Complications/epidemiology/etiology/diagnosis Activities of Daily Living Clinical Protocols age-related surgical risk factors aging delirium geriatric assessment gerontology health informatics multidisciplinary older patients palliative care perioperative perioperative assessment prospective study screening surgery surgical care surgical medicine |
| Polypharmacy and anticholinergic burden as risk factors for postoperative delirium in surgical medicine | Moellmann, H. L. Boulghoudan, S. Kuhlmann, J. Rahm, L. Frohnhofen, H. | Z Gerontol Geriatr | 2025 |
Anticholinergic burden Geriatric assessment Polypharmacy Postoperative delirium Surgery |
| Delirium and Cognitive Screening in National Hip Fracture Registries: Scoping Review Protocol | Merriman, N. A. Penfold, R. S. Brent, L. Hickey, P. Walsh, M. E. Sexton, E. Coughlan, T. MacLullich, A. M. J. Johansen, A. Ojeda-Thies, C. Hall, A. J. Blake, C. | HRB Open Res | 2024 |
audit cognition delirium hip fracture older adults registries scoping review protocol |
| Dexmedetomidine for delirium prevention in adult patients following cardiac surgery: a meta-analysis of randomized controlled trials | Meng, C. Wang, D. Zhao, Y. Sun, J. Miao, G. Chen, L. Bai, Y. Liu, P. | J Cardiothorac Surg | 2025 |
*Dexmedetomidine/therapeutic use/administration & dosage Humans *Cardiac Surgical Procedures/adverse effects *Randomized Controlled Trials as Topic *Delirium/prevention & control *Postoperative Complications/prevention & control Adult Hypnotics and Sedatives/therapeutic use/administration & dosage Cardiac surgery Delirium Dexmedetomidine |
| Mechanisms of perioperative neuronal injury and the search for therapies | Marshall, T. J. Watne, L. O. Sanders, R. D. | Br J Anaesth | 2025 |
biomarkers inflammation ischaemia kynurenine pathway neurofilament light neuronal injury perioperative medicine |
| Delirium Management Quality Improvement Project to Improve Awareness and Screening in a Medical ICU | Makhija, H. Digrande, K. Awan, O. Buhr, R. G. Saggar, R. Ramirez, V. Tarumoto, R. Fine, J. M. Malhotra, A. Needham, D. M. Martin, J. L. Kamdar, B. B. | Nurs Rep | 2024 |
benzodiazepines delirium intensive care unit nursing outcome assessment quality improvement |
| Advantages of the standardized use of preoperative fascia iliaca block versus conventional analgesia in older adults with fragility hip fracture: A retrospective cohort study at two hospitals in Colombia | Libos Zabala, A. Tihanyi Feldman, J. Bernate, J. D. Ricaurte, L. Morales, D. C. Patiño, A. F. Pesantez, R. F. Salavarrieta, J. E. Sanint, V. López, A. M. Olarte, C. M. | Sci Prog | 2025 |
Aged Aged, 80 and over Female Humans Male *Analgesia/methods Analgesics, Opioid/therapeutic use Colombia/epidemiology Delirium/drug therapy/epidemiology/etiology Fascia/innervation/drug effects *Hip Fractures/surgery *Nerve Block/methods *Pain Management/methods Pain, Postoperative/drug therapy/etiology Retrospective Studies Hip fracture delirium fascia iliaca block opioid use orthogeriatrics |
| Effectiveness of a virtual reality-based sensory stimulation intervention in preventing delirium in intensive care units: a randomised-controlled trial protocol | Liang, S. Liu, Y. Wen, T. Luo, D. He, M. Tian, J. | BMJ Open | 2025 |
Humans *Delirium/prevention & control *Intensive Care Units *Virtual Reality Randomized Controlled Trials as Topic Quality of Life Virtual Reality Exposure Therapy/methods Delirium & cognitive disorders Intensive & critical care Virtual Reality |
| Construction and application of a stratified nursing intervention program for postoperative delirium after Stanford type A aortic dissection: a quasi-experimental trial | Li, X. Zheng, M. Lin, A. Chen, C. Wu, Y. Zhang, H. Yin, Z. | Perioper Med (Lond) | 2025 |
Aortic dissection Clinical application Delphi method Nursing care plan Postoperative delirium |
| Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial | Li, L. Zhang, L. Wu, X. Zeng, Z. | Ther Clin Risk Manag | 2025 |
Icu delirium head and neck tumor reconstruction midazolam propofol sedation |
| Effect of Intraoperative Midazolam on Postoperative Delirium in Older Surgical Patients: A Prospective, Multicenter Cohort Study | Li, H. Liu, C. Yang, Y. Wu, Q. P. Xu, J. M. Wang, D. F. Sun, J. J. Mao, M. M. Lou, J. S. Liu, Y. H. Cao, J. B. Duan, C. Y. Mi, W. D. | Anesthesiology | 2025 |
Humans *Midazolam/adverse effects/administration & dosage Aged Male Female Prospective Studies Cohort Studies *Postoperative Complications/epidemiology/diagnosis *Delirium/epidemiology/chemically induced *Hypnotics and Sedatives/adverse effects Intraoperative Care/methods Aged, 80 and over Emergence Delirium/epidemiology/diagnosis/chemically induced |
| The association between preoperative lacunar infarcts and postoperative delirium in elderly patients undergoing major abdominal surgery: a prospective cohort study | Li, D. Gu, P. Wang, Y. Yao, Y. Fan, D. | Aging Clin Exp Res | 2025 |
Humans Aged Male Female Prospective Studies *Abdomen/surgery *Delirium/etiology/epidemiology *Postoperative Complications/epidemiology/etiology Risk Factors *Stroke, Lacunar/surgery Aged, 80 and over Elderly patients Lacunar infarcts Major abdominal surgery Postoperative delirium Regional cerebral oxygen saturation |
| The association between pain, analgesia, and delirium among critically ill adults: a systematic review and meta-analysis | Leong, A. Y. Edginton, S. Lee, L. A. Jaworska, N. Burry, L. Fiest, K. M. Doig, C. J. Niven, D. J. | Intensive Care Med | 2025 |
Analgesics Critical care Delirium Pain Pain measurement |
| Promoting Family Involvement in the Management of Delirium in Intensive Care: Scoping Review | Lange, S. Mędrzycka-Dąbrowska, W. | Medicina (Kaunas) | 2024 |
Humans *Delirium/therapy *Family/psychology Critical Care/methods Intensive Care Units/organization & administration Critical Illness/psychology/therapy critical care delirium management family involvement family-centered care intensive care units scoping review |
| Strategies to prevent postoperative delirium: a comprehensive evaluation of anesthesia selection and drug intervention | Lan, S. Liang, S. Wu, H. Deng, S. Sun, K. Ye, C. Yang, L. Ciren, L. Li, J. | Front Psychiatry | 2024 |
anesthesia delirium hip fractures perioperative medication prevention treatment |
| Clinical Utility and Performance of the Traditional Chinese Version of the 4-As Test for Delirium due to Traumatic Brain Injury | Lai, Y. H. Lin, C. J. Su, I. C. Huang, S. W. Hsiao, C. C. Jao, Y. L. Chen, P. Y. Traynor, V. Lee, C. Y. Chen, T. J. Ho, M. H. Chiu, H. Y. | J Acad Consult Liaison Psychiatry | 2025 |
4at delirium reliability traumatic brain injury validity |
| The Role of Stress Hyperglycemia on Delirium Onset | Lagonigro, E. Pansini, A. Mone, P. Guerra, G. Komici, K. Fantini, C. | J Clin Med | 2025 |
cognitive impairment delirium diabetes stress hyperglycemia |
| Effects of Intravenous Hydroxyzine Versus Haloperidol Monotherapy for Delirium: A Retrospective Study | Kubo, K. Takehara, M. Hirata, M. Huh, S. Kawano, S. Uchida, H. Takeuchi, H. | J Clin Psychiatry | 2025 |
Humans *Delirium/drug therapy *Haloperidol/administration & dosage/therapeutic use/adverse effects Female Male Retrospective Studies Aged *Hydroxyzine/administration & dosage/therapeutic use *Antipsychotic Agents/administration & dosage/adverse effects Aged, 80 and over *Administration, Intravenous Treatment Outcome Middle Aged |
| Prediction of delirium occurrence using machine learning in acute stroke patients in intensive care unit | Kim, H. Kim, M. Kim, D. Y. Seo, D. G. Hong, J. M. Yoon, D. | Front Neurosci | 2024 |
delirium early diagnosis ischemic stroke machine learning vital signs |
| Role of Quetiapine in the Prevention of ICU Delirium in Elderly Patients at a High Risk | Kamel, W. Y. Kamel, H. Y. Elsherif, I. M. | J Crit Care Med (Targu Mures) | 2024 |
Cam-icu Icdsc delirium elderly quetiapine |
| A Critical Reappraisal of Haloperidol for Delirium Management in the Intensive Care Unit: Perspective from Psychiatry | Jiang, S. Gunther, M. | J Clin Med | 2025 |
acute brain failure antipsychotics critical care delirium dopamine encephalopathy haloperidol intensive care unit psychopharmacology |
| Advancing Delirium Treatment Trials in Older Adults: Recommendations for Future Trials From the Network for Investigation of Delirium: Unifying Scientists (NIDUS) | Devlin, J. W. Sieber, F. Akeju, O. Khan, B. A. MacLullich, A. M. J. Marcantonio, E. R. Oh, E. S. Agar, M. R. Avelino-Silva, T. J. Berger, M. Burry, L. Colantuoni, E. A. Evered, L. A. Girard, T. D. Han, J. H. Hosie, A. Hughes, C. Jones, R. N. Pandharipande | Crit Care Med | 2025 |
Humans *Delirium/therapy/drug therapy Aged *Randomized Controlled Trials as Topic Research Design |
| Critical care nurses' prioritisation of patient care, including delirium prevention and management strategies: A mixed-method study | Crowe, S. Howard, A. F. | Aust Crit Care | 2025 |
Critical care Delirium Mixed-method Nursing care Prioritisation |
| Rocking Motion Therapy for Delirious Patients in the ICU: A Multicenter Randomized Clinical Trial | Collet, M. O. Nielsen, G. M. Thorn, L. Laerkner, E. Fischer, S. Bang, B. Langvad, A. Granholm, A. Egerod, I. | Crit Care Med | 2025 |
Humans *Delirium/therapy Male Female *Intensive Care Units Aged Middle Aged Treatment Outcome Coma/therapy |
| Appraising the Factors Associated with Delirium Care Behaviours and Barriers to Their Assessment Among Clinical Nurses: A Cross-Sectional Study | Chow, S. K. Y. Chan, S. C. | Int J Environ Res Public Health | 2024 |
Humans *Delirium/nursing/therapy/diagnosis Cross-Sectional Studies Female Male Adult *Health Knowledge, Attitudes, Practice Surveys and Questionnaires Nursing Staff, Hospital/psychology Middle Aged Young Adult Nurses/psychology barriers behaviour delirium knowledge nurse |
| Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction | Chen, Z. Zuo, Z. Zhang, Y. Shan, G. Zhang, L. Gong, M. Ye, Y. Ma, Y. Jin, Y. | Brain Behav | 2025 |
Humans *Bibliometrics *Postoperative Cognitive Complications/etiology/epidemiology *Neuroinflammatory Diseases/etiology epigenetic modifications neuroinflammation perioperative neurocognitive disorders postoperative cognitive dysfunction postoperative delirium |
| Comparative risks and clinical outcomes of midazolam versus other intravenous sedatives in critically ill mechanically ventilated patients: A systematic review and meta-analysis of randomized trials | Chen, Y. X. Ho, M. H. | Intensive Crit Care Nurs | 2025 |
Delirium Intensive care Mechanical ventilation Meta-analysis as topic Midazolam Sedation |
| Cerebral Oximetry Index-Guided Blood Pressure Management During Cardiopulmonary Bypass Reduces Postoperative Delirium in Patients with Acute Type A Aortic Dissection | Chen, X. Xie, W. Li, W. Gao, J. | J Cardiothorac Vasc Anesth | 2025 |
aortic dissection blood pressure management cardiopulmonary bypass cerebral autoregulation delirium |
| Analysis of risk factors for delirium in elderly patients with head and neck cancer after free flap reconstruction surgery | Chen, S. X. Qin, F. Y. Yu, X. M. Huang, Y. J. Zhou, S. N. Gu, W. P. Chen, Q. M. | Zhonghua Kou Qiang Yi Xue Za Zhi | 2025 |
Humans Risk Factors Male Female *Head and Neck Neoplasms/surgery Aged Retrospective Studies *Plastic Surgery Procedures/adverse effects *Free Tissue Flaps *Postoperative Complications/etiology *Delirium/etiology Logistic Models |
| Emergency Nurses' Perspectives on Adopting Geriatric Screenings for Cognitive Impairment: A Qualitative Study | Chary, A. N. Bhananker, A. R. Gilmore-Bykovskyi, A. Naik, A. D. Samuels-Kalow, M. Godwin, K. M. Kennedy, M. | J Emerg Nurs | 2025 |
Delirium Dementia Emergency medicine Emergency nursing Geriatrics Screening implementation |
| Development and validation of a nomogram for delirium in the old ischaemic stroke patients | Cai, X. Yu, X. Qin, J. Zhou, K. Li, Z. Zhang, J. Zheng, D. Wang, P. Yan, F. | Psychogeriatrics | 2025 |
Humans Male Female *Nomograms Aged *Ischemic Stroke/complications/diagnosis *Delirium/diagnosis/etiology China/epidemiology Aged, 80 and over Cross-Sectional Studies Risk Factors ROC Curve Middle Aged Incidence Stroke/complications ischaemic stroke nomogram post‐stroke delirium |
| Melatonin Low-Dose for Prevention of Delirium in Critically Ill Patients: A Multi-centre, Randomized, Placebo-controlled Feasibility Trial (MELLOW) | Burry, L. D. Williamson, D. R. Detsky, M. E. Bernard, F. Foster, J. R. Mehta, S. Pinto, R. Scales, D. C. Rose, L. | Chest | 2025 |
Delirium feasibility intensive care melatonin prevention randomized controlled trial |
| The fine line between relief and risk: new insights into postoperative delirium | Berger-Estilita, J. Bilotta, F. | Br J Anaesth | 2025 |
Humans Anesthesia/adverse effects/methods *Emergence Delirium/diagnosis/epidemiology/etiology/prevention & control *Pain Management/methods *Pain, Postoperative/complications/epidemiology/psychology/therapy Risk Factors Systematic Reviews as Topic multimodal analgesia neurocognitive outcome postoperative delirium postoperative pain precision anaesthesia |
| Clinical and intracranial electrophysiological signatures of post-operative and post-ictal delirium | Banks, M. I. Dappen, E. R. Matar, E. Hayum, B. D. Sutherland, M. H. Krause, B. M. Kawasaki, H. Sanders, R. D. Nourski, K. V. | Clin Neurophysiol | 2025 |
Consciousness Epilepsy Functional connectivity Neurosurgery Sleep Slow wave activity |
| Olanzapine versus quetiapine in critically ill patients with hyperactive delirium: Protocol for a multicentre, cluster-randomised, double-crossover, pragmatic clinical trial (CALM-ICU) | Ankravs, M. J. Udy, A. Bellomo, R. Presneill, J. J. Adams, L. Abdelhamid, Y. A. Bailey, M. Board, J. Byrne, K. Eastwood, G. Le Guen, M. Martin, E. L. Plummer, M. P. Richardson, M. Sharrock, L. Young, M. Deane, A. M. | Crit Care Resusc | 2024 |
Antipsychotic agents Critical illness Delirium Intensive care units Olanzapine Quetiapine |
| Windows in the ICU and Postoperative Delirium: A Retrospective Cohort Study | Anderson, D. C. Warner, P. E. Smith, M. R. Albanese, M. L. Mueller, A. L. Messervy, J. Renne, B. C. Smith, S. J. | Crit Care Med | 2025 |
ICU, Delirium, CAM, Room Design, RASS |
| Barriers to nurse-led delirium management in intensive care units: an integrative systematic review using COM-B model | Almoliky, M. A. Alkubati, S. Saleh, K. Alsaqri, S. Al-Ahdal, S. A. Albani, G. Sultan, M. A. | BMC Nurs | 2025 |
Barriers, COM-B model, Delirious patient, Delirium, Delirium management, ICU nursing |
| Melatonin: A Review of the Evidence for Use in Hospital Settings | Adattini, J. A. Wills, C. Martin, J. H. | Pharmacol Res Perspect | 2025 |
*Melatonin/therapeutic use/administration & dosage Humans *Sleep Initiation and Maintenance Disorders/drug therapy *Cost-Benefit Analysis Hospitalization Off-Label Use Hypnotics and Sedatives/therapeutic use/adverse effects Delirium/prevention & control/drug therapy |
| Factors Influencing Nurses' Knowledge About Delirium in Acute Care Settings in Hail Region, Saudi Arabia: A Cross-Sectional Study | Almoliky, M. A. Alkubati, S. A. Alsaqri, S. H. Saleh, K. A. Sultan, M. A. Al-Ahdal, S. A. Balawi, A. M. Moatakef, H. I. | Risk Manag Healthc Policy | 2024 |
Saudi Arabia, delirium, intensive care unit, knowledge |
| Association of remimazolam with delirium and cognitive function: A systematic review and meta-analysis of randomised controlled trials | Arias, J. A. Wegner, G. R. M. Wegner, B. F. M. Silva, L. S. Bezerra, F. J. L. Filardi, R. G. M. | Eur J Anaesthesiol | 2024 | |
| The Association Between Delirium Upon Admission to a Rehabilitation Hospital and Motor Rehabilitation Outcomes Among Hip Fracture Surgery Patients: A Historical Cohort Study | Balzer, A. Novak, A. M. Marom, P. Schwartz, O. Brik, M. Slutzki, K. Heruti, R. J. Dankner, R. | J Clin Med | 2024 |
delirium, geriatrics, hip fracture, older adults, rehabilitation |
| Disorientation as a delirium feature in non-intubated patients: development and evaluation of diagnostic accuracy of the 'Confusion Assessment Method for Intermediate Care Unit' (CAM-IMC) - a prospective cohort study | Beyer, L. P. Gathen, L. V. Z. Rayah, B. E. Dewald, O. Zieschang, T. Diers, A. Ely, E. W. Guenther, U. | BMC Anesthesiol | 2024 |
Humans Prospective Studies Male Female Aged *Confusion/diagnosis Middle Aged Cohort Studies *Delirium/diagnosis Postoperative Complications/diagnosis Sensitivity and Specificity Cardiac Surgical Procedures Intensive Care Units Reproducibility of Results Cam-icu Cam-imc Delirium Disorientation Non-intubated Pod |
| Increased cell-free DNA in CSF and serum of hip fracture patients with delirium | Bratseth, V. Watne, L. O. Neerland, B. E. Halaas, N. B. Pollmann, C. T. Karabeg, A. Odegaard, O. T. Sydnes, K. Zetterberg, H. Seljeflot, I. Helseth, R. | Brain Commun | 2025 |
cell-free DNA, delirium, neurofilament light chain, neuroinflammation, neutrophil extracellular traps |
| Haloperidol dopamine receptor occupancy and antagonism correspond to delirium agitation scores and EPS risk: A PBPK-PD modeling analysis | Burkat, P. M. | J Psychopharmacol | 2025 |
Antagonism, Rass, delirium, haloperidol, occupancy |
| Identifying Symptoms of Delirium from Clinical Narratives Using Natural Language Processing | Chen, A. Paredes, D. Yu, Z. Lou, X. Brunson, R. Thomas, J. N. Martinez, K. A. Lucero, R. J. Magoc, T. Solberg, L. M. Snigurska, U. A. Ser, S. E. Prosperi, M. Bian, J. Bjarnadottir, R. I. Wu, Y. | Proc (IEEE Int Conf Healthc Inform) | 2024 |
clinical natural language processing, deep learning, delirium, medication information extraction, named entity recognition |
| Association between the geriatric nutritional risk index and postoperative delirium in gastric surgery patients: an analysis of the MIMIC-IV database | Chen, Y. Chen, H. Zhuang, Y. Wang, Y. Dai, Z. | BMC Anesthesiol | 2024 |
Humans Female Male Aged *Postoperative Complications/epidemiology *Databases, Factual Middle Aged *Nutritional Status Malnutrition/epidemiology Delirium/epidemiology/etiology Geriatric Assessment/methods Risk Factors Nutrition Assessment Incidence Stomach/surgery Aged, 80 and over Gnri Gastric surgery MIMIC-IV database Nutritional status Postoperative delirium |