NIDUS Delirium Bibliography

Delirium Bibliography books graphic What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title: Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial

Authors: Bellapart, J. Appadurai, V. Lassig-Smith, M. Stuart, J. Zappala, C. Boots, R.

Year: 2020

Journal: Crit Care Res Pract

Abstract: INTRODUCTION: Sleep deprivation is a contributor for delirium in intensive care. Melatonin has been proposed as a pharmacological strategy to improve sleep, but studies have shown that the increase in plasma levels of melatonin do not correlate to a beneficial clinical effect; in addition, melatonin’s short half-life may be a major limitation to achieving therapeutic levels. This study applies a previously published novel regimen of melatonin with proven sustained levels of melatonin during a 12 h period. In this study, the aim is to determine if such melatonin dosing positively influences on the sleep architecture and the incidence of delirium in intensive care. METHODS: Single center, randomized control trial with consecutive recruitment over 5 years. Medical and surgical patients were in a recovery phase, all weaning from mechanical ventilation. Randomized allocation to placebo or enteral melatonin, using a previously described regimen (loading dose of 3 mg at 21 h, followed by 0.5 mg hourly maintenance dose until 03am through a nasogastric tube). Sleep recordings were performed using polysomnogram at baseline (prior to intervention) and the third night on melatonin (postintervention recording). Delirium was assessed using the Richmond Agitation and the Confusion Assessment Method Scales. Environmental light and noise levels were recorded using a luxmeter and sound meter. RESULTS: 80 patients were screened, but 33 were recruited. Sleep studies showed no statistical differences on arousal index or length of sleep. Baseline delirium scores showed no difference between groups when compared to postintervention scores. RASS scores were 1 in both groups at baseline, compared to zero (drug group) and 0.5 (placebo group) posttreatment. CAM scores were zero (drug group) and 1 (placebo group) at baseline, compared to zero (in both groups) postintervention. CONCLUSION: High levels of plasma melatonin during the overnight period of intensive care cohort patients did not improve sleep nor decreased the prevalence of delirium. This trial is registered with Anzctr.org.au/ACTRN12620000661976.aspx.

PMID: PMC7530506

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Total Records Found: 5897, showing 100 per page
Title	Authors	Journal	Year	Keywords
Challenges in detecting and managing mild cognitive impairment in primary care: a focus group study in Shanghai, China	Lu, Y. Liu, C. Wells, Y. Yu, D.	BMJ Open	2022	Caregivers/psychology China *Cognitive Dysfunction/diagnosis/therapy Focus Groups Humans Primary Health Care/methods delirium & cognitive disorders primary care qualitative research
The Age-adjusted Charlson Comorbidity Index predicts post-operative delirium in the elderly following thoracic and abdominal surgery: A prospective observational cohort study	Liu, J. Li, J. He, J. Zhang, H. Liu, M. Rong, J.	Front Aging Neurosci	2022	Age-adjusted Charlson Comorbidity Index elderly observational study post-operative delirium thoracic and abdominal surgery
Early alteration of peripheral blood lymphocyte subsets as a risk factor for delirium in critically ill patients after cardiac surgery: A prospective observational study	Li, X. Cheng, W. Zhang, J. Li, D. Wang, F. Cui, N.	Front Aging Neurosci	2022	CD4+ T cells cardiac surgery critical care delirium risk factors commercial or financial relationships that could be construed as a potential conflict of interest.
Association of electroencephalogram epileptiform discharges during cardiac surgery with postoperative delirium: An observational study	Li, N. Liu, X. Gao, Y. Yin, L. Zhao, W. Ma, R. Ni, X.	Front Surg	2022	cardiac surgery cardiopulmonary bypass electroencephalography epileptiform discharges postoperative delirium commercial or financial relationships that could be construed as a potential conflict of interest.
Patients' and Relatives' Experiences of Delirium in the Intensive Care Unit-A Qualitative Study	Lange, S. Mędrzycka-Dąbrowska, W. Friganović, A. Religa, D. Krupa, S.	Int J Environ Res Public Health	2022	Aged Caregivers *Delirium/epidemiology Family/psychology Female Humans Intensive Care Units Male Qualitative Research delirium family relations family-centered care patients
Survey on Current Practice of Canadian Physicians Regarding the Investigation in Older Patients with Delirium	Laguë, A. Boucher, V. Joo, P. Yadav, K. Morasse, C. Émond, M.	Can Geriatr J	2022	delirium geriatric older patients interest exist.
Clinical phenotypes of delirium in patients admitted to the cardiac intensive care unit	Ko, R. E. Kim, S. Lee, J. Park, S. Bae, D. Choi, K. H. Park, T. K. Chung, C. R. Yang, J. H.	PLoS One	2022	Delirium/epidemiology/etiology Hospital Mortality Hospitalization Humans Intensive Care Units Phenotype Retrospective Studies
Delirium, dementia, and depression (3D) assessment of older patients in the emergency department: 5-year survival analysis	Kılıçaslan, İ Thet, M. S. Karahacıoğlu, B. Sevim, M. Ülger, Z. Aslaner, M. A. Kılıçaslan, B.	Turk J Med Sci	2022	Aged Delirium/diagnosis/epidemiology Dementia/diagnosis/epidemiology Depression/diagnosis/epidemiology Emergency Service, Hospital Geriatric Assessment Humans Prospective Studies Quality of Life Survival Analysis Delirium dementia depression geriatric emergency department older mental health disorder survival
Charles Bonnet Syndrome With Superimposed Delirium	Karson, C. Kang, C. Albrecht, B. Levin, G.	Cureus	2022	antipsychotic cbs charles bonnet syndrome charles bonnet syndrome plus deafferentation theory delirium mental health stigma perceptual release theory visual hallucination
Prevalence and Long-Term Prognosis of Post-Intensive Care Syndrome after Sepsis: A Single-Center Prospective Observational Study	Inoue, S. Nakanishi, N. Sugiyama, J. Moriyama, N. Miyazaki, Y. Sugimoto, T. Fujinami, Y. Ono, Y. Kotani, J.	J Clin Med	2022	Barthel Index Hospital Anxiety and Depression Scale Short-Memory Questionnaire delirium long-term outcome post-intensive care syndrome septic encephalopathy
Mental health-related quality of life is related to delirium in intensive care patients	Hofhuis, J. G. M. Schermer, T. Spronk, P. E.	Intensive Care Med	2022	Critical Care Delirium Follow-Up Studies Humans Intensive Care Units Prospective Studies Quality of Life Delirium Health-related quality of life Icu Mcs12 Mental health
Noise pareidolia test for predicting delirium in hospitalized older patients with cognitive decline	Hashimoto, Y. Kano, O. Ebihara, S.	Geriatr Gerontol Int	2022	cognitive decline delirium hospitalization older patients pareidolia
Postoperative Delirium Severity and Recovery Correlate With Electroencephalogram Spectral Features	Guay, C. S. Kafashan, M. Huels, E. R. Jiang, Y. Beyoglu, B. Spencer, J. W. Geczi, K. Apakama, G. Ju, Y. S. Wildes, T. S. Avidan, M. S. Palanca, B. J. A.	Anesth Analg	2022
Prevention and treatment of delirium in intensive care: Hermeneutics of experiences of the nursing team	Gómez Tovar, L. O. Henao-Castaño Á, M. Troche-Gutiérrez, I. Y.	Enferm Intensiva (Engl Ed)	2022	Critical Care Delirium/prevention & control Hermeneutics Humans Intensive Care Units Qualitative Research Atención de enfermería Delirium Hermenéutica Intensive care unit Nursing care Unidad de cuidados intensivos
How do predisposing factors differ between delirium motor subtypes? A systematic review and meta-analysis	Ghezzi, E. S. Greaves, D. Boord, M. S. Davis, D. Knayfati, S. Astley, J. M. Sharman, R. L. S. Goodwin, S. I. Keage, H. A. D.	Age Ageing	2022	Aged *Delirium/diagnosis/epidemiology Female Humans Male Psychomotor Agitation Risk Assessment Risk Factors hyperactive hypoactive mixed older people risk factor systematic review
Applying the geriatric 5Ms in critical care: the ICU-5Ms	Geen, O. Perrella, A. Rochwerg, B. Wang, X. M.	Can J Anaesth	2022	Aged Critical Care Frail Elderly Frailty Humans Intensive Care Units critical care delirium frailty geriatrics polypharmacy
Delirium in Persons With Dementia: Integrating the 4Ms of Age-Friendly Care as a Set Into the Care of Older People	Fick, D. M. Shrestha, P.	J Gerontol Nurs	2022	Aged Delirium Dementia Humans
The effect of melatonin on prevention of postoperative delirium after lower limb fracture surgery in elderly patients: a randomized double blind clinical trial	Fazel, M. R. Mofidian, S. Mahdian, M. Akbari, H. Razavizadeh, M. R.	Int J Burns Trauma	2022	Melatonin aged delirium orthopedics surgery affiliations with or involvement in any organization or entity with any financial interest (such as honoraria educational grants participation in speakers’ bureaus membership, employment, consultancies, stock ownership, or other equity interest and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.
Risk factors for delirium after surgery for craniocerebral injury in the neurosurgical intensive care unit	Chen, R. Y. Zhong, C. H. Chen, W. Lin, M. Feng, C. F. Chen, C. N	World J Clin Cases	2022	Brain injury Delirium Intensive care unit Neurosurgery Risk factors declare.
Risk factors and a nomogram model for postoperative delirium in elderly gastric cancer patients after laparoscopic gastrectomy	Chen, J. Ji, X. Xing, H.	World J Surg Oncol	2022	Aged Albumins Delirium/diagnosis/epidemiology/etiology Fibrinogen Gastrectomy/adverse effects Humans Laparoscopy/adverse effects Nomograms Postoperative Complications/etiology/surgery Retrospective Studies Risk Factors Sleep Aids, Pharmaceutical Stomach Neoplasms/complications Elderly Gastric cancer Nomogram model Postoperative delirium
Self-efficacy of caring for patients in the intensive care unit with delirium: Development and validation of a scale for intensive care unit nurses	Chang, Y. L. Hsieh, M. J. Chang, Y. C. Yeh, S. L. Chen, S. W. Tsai, Y. F.	Aust Crit Care	2022	Delirium Instrument development Intensive care unit Reliability Self-efficacy Validity
A nurse-led intervention to reduce the incidence and duration of delirium among adults admitted to intensive care: A stepped-wedge cluster randomised trial	Brennan, K. Sanchez, D. Hedges, S. Lynch, J. Hou, Y. C. Al Sayfe, M. Shunker, S. A. Bogdanoski, T. Hunt, L. Alexandrou, E. He, S. Mai, H. Rolls, K. Frost, S. A.	Aust Crit Care	2022	Delirium prevention Intensive care Nurse-led interventions Stepped-wedge cluster randomised trials
Association of cholinesterase activities and POD in older adult abdominal surgical patients	Bosancic, Z. Spies, C. D. Müller, A. Winterer, G. Piper, S. K. Heinrich, M	BMC Anesthesiol	2022	Aged Butyrylcholinesterase Cholinergic Agents Delirium/etiology Female Humans Male Postoperative Complications/diagnosis Prospective Studies Sodium Oxybate Cholinesterase activity Older adults Pod Postoperative
Management of delirium in older adults: challenges and opportunities	Bingham, K. S. Flint, A. J.		2022	Aged Delirium/diagnosis/therapy Dementia Humans
Emergence delirium after intracranial neurosurgery- a prospective cohort study	Bharadwaj, S. Konar, S. Akash, V. S. Gopalakrishna, K. N. Chakrabarti, D. Kamath, S.	J Clin Neurosci	2022	Adolescent Adult Anesthesia Recovery Period Anesthetics, Inhalation Emergence Delirium/epidemiology/etiology Humans *Neurosurgery Prospective Studies Risk Factors Emergence delirium Hyperactive delirium Hypoactive delirium Incidence Neurosurgery Risk factors
A novel approach for the detection of cognitive impairment and delirium risk in older patients undergoing spine surgery	Barreto Chang, O. L. Whitlock, E. L. Arias, A. D. Tsoy, E. Allen, I. E. Hellman, J. Bickler, P. E. Miller, B. Possin, K. L.	J Am Geriatr Soc	2022	anesthesia and surgery cognitive assessment postoperative delirium postoperative outcomes
Temporal Variability in Inflammatory Gene Methylation and Delirium in Critically Ill Patients	Alexander, S. A. Conley, Y. P. Girard, T. D. McVerry, B. J. Ren, D.	Am J Crit Care	2022	Adolescent Brain Injuries Critical Illness Delirium/genetics Female Humans Intensive Care Units Male Methylation Respiration, Artificial
Machine Learning-Based Prediction Models for Delirium: A Systematic Review and Meta-Analysis	Xie, Q. Wang, X. Pei, J. Wu, Y. Guo, Q. Su, Y. Yan, H. Nan, R. Chen, H. Dou, X.	J Am Med Dir Assoc	2022	Machine learning algorithm delirium meta-analysis predictive model systematic review
Baseline Anxiety and Depression and Risk for ICU Delirium: A Prospective Cohort Study	Wu, T. T. Kooken, R. Zegers, M. Ko, S. Bienvenu, O. J. Devlin, J. W. van den Boogaard, M.	Crit Care Explor	2022	anxiety delirium depression intensive care mental disorders interest.
Preoperative Cognitive Impairment and Postoperative Delirium in Elderly Surgical Patients - a Retrospective Large Cohort Study	Weiss, Y. Zac, L. Refaeli, E. Ben-Yishai, S. Zegerman, A. Cohen, B. Matot, I.	Ann Surg	2022
Goal-directed therapy based on rScO(2) monitoring in elderly patients with one-lung ventilation: a randomized trial on perioperative inflammation and postoperative delirium	Wang, J. Y. Li, M. Wang, P. Fang, P.	Trials	2022	Aged Delirium/diagnosis/etiology/prevention & control Goals Humans Inflammation/diagnosis/etiology/prevention & control Lactates One-Lung Ventilation/adverse effects Oxygen Pain, Postoperative S100 Calcium Binding Protein beta Subunit Agitation during awakening Awakening time Goal-directed therapy Inflammatory factors Lactate Postoperative delirium Randomized controlled trial Regional saturation of cerebral oxygenation
Impact of propofol versus sevoflurane on the incidence of postoperative delirium in elderly patients after spine surgery: study protocol of a randomized controlled trial	Wang, J. H. Lv, M. Zhang, H. X. Gao, Y. Chen, T. T. Wan, T. T. Wang, Y. L.	Trials	2022	Aged Anesthetics, Inhalation/adverse effects Delirium/diagnosis/epidemiology/etiology Humans Incidence *Propofol/adverse effects Randomized Controlled Trials as Topic Sevoflurane/adverse effects Delirium Propofol Randomized controlled trial Sevoflurane Spine surgery
Impact of propofol versus sevoflurane on the incidence of postoperative delirium in elderly patients after spine surgery: study protocol of a randomized controlled trial	Wang, J. H. Lv, M. Zhang, H. X. Gao, Y. Chen, T. T. Wan, T. T. Wang, Y. L.	Trials	2022	Aged Anesthetics, Inhalation/adverse effects Delirium/diagnosis/epidemiology/etiology Humans Incidence *Propofol/adverse effects Randomized Controlled Trials as Topic Sevoflurane/adverse effects Delirium Propofol Randomized controlled trial Sevoflurane Spine surgery
Potential Value of Serum Uric Acid in the Identification of Postoperative Delirium in Geriatric Patients Undergoing Knee Replacement	Wang, F. Tang, X. Wang, J. Liu, S. Wu, X. Dong, R. Lin, X. Wang, B. Bi, Y.	Front Aging Neurosci	2022	Alzheimer-related biomarkers postoperative delirium prediction risk factor serum uric acid
Patient Outcomes After Delirium Screening and Incident Alzheimer's Disease or Related Dementias in Skilled Nursing Facilities	Vo, Q. T. Koethe, B. Holmes, S. Simoni-Wastila, L. Briesacher, B. A.	J Gen Intern Med	2022	Alzheimer’s disease Medicare delirium dementia skilled nursing
Delirium in head trauma: looking for a culprit	Villani, E. R. Franza, L. Cianci, R.	Rev Recent Clin Trials	2022	Delirium Falls Geriatrics Head trauma Inflammation Trauma
Timing, Threshold, and Duration of Intraoperative Hypotension in Cardiac Surgery: Their Associations With Postoperative Delirium	Ushio, M. Egi, M. Fujimoto, D. Obata, N. Mizobuchi, S.	J Cardiothorac Vasc Anesth	2022	Cardiac valvular surgery Intraoperative hypotension Post cardiopulmonary bypass Postoperative delirium Threshold of mean arterial pressure
Detecting delirium in nursing home residents using the Informant Assessment of Geriatric Delirium (I-AGeD): a validation pilot study	Urfer Dettwiler, P. Zúñiga, F. Bachnick, S. Gehri, B. de Jonghe, J. F. M. Hasemann, W.	Eur Geriatr Med	2022	Aged Cross-Sectional Studies Delirium/diagnosis/epidemiology Geriatric Assessment/methods Humans Nursing Homes Pilot Projects Prospective Studies Delirium Delirium assessment Validation study
Association of preoperative frailty and postoperative delirium in older cancer patients undergoing elective abdominal surgery: a prospective observational study in Taiwan	Tsai, C. Y. Liu, K. H. Lai, C. C. Hsu, J. T. Hsueh, S. W. Hung, C. Y. Yeh, K. Y. Hung, Y. S. Lin, Y. C. Chou, W. C.	Biomed J	2022	cancer delirium frailty. surgery
Delirium and Cortical Complexity: Divergent Changes in Alpha and Theta Bands	Tanabe, S. Parker, M. Lennertz, R. Pearce, R. A. Banks, M. I. Sanders, R. D.	J Gerontol A Biol Sci Med Sci	2022
Escaping delirium: Designing an escape room active learning experience for geriatric resource nurses	Stoller, A. Iannuzzo, S. Davis, K.	Geriatr Nurs	2022	Creative problem solving Critical thinking Delirium Escape rooms Nursing workforce development
Perivascular spaces visible on magnetic resonance imaging predict subsequent delirium in older patients	Song, Q. Zhao, Y. Lin, T. Yue, J.	Front Aging Neurosci	2022	cerebral small vessel disease delirium magnetic resonance imaging older people perivascular spaces
Postoperative delirium does not affect cardiopulmonary exercise testing in aged patients undergoing cardiac valve surgery	Shimomoto, Y. Mukaiyama, K. Hori, T. Inaki, Y. Masai, T. Hayashi, Y.	JA Clin Rep	2022	Cardiac rehabilitation Cardiopulmonary exercise testing Heart surgery Postoperative delirium
Silent cerebral ischemia detected by magnetic resonance imaging can predict postoperative delirium after total arch replacement for aneurysm	Shibagaki, K. Shirasaka, T. Sawada, J. Saijo, Y. Kunioka, S. Kikuchi, Y. Kamiya, H.	JTCVS Open	2022	AAA, aortic arch aneurysm AR, arch replacement CI, confidence interval DSWMH, deep subcortical white matter hyperintensities ICDSC, Intensive Care Delirium Screening Checklist ICU, intensive care unit MRI, magnetic resonance imaging NCS, Neelon and Champagne confusion scale NPD, nonpostoperative delirium OR, odds ratio PD, postoperative delirium PVH, periventricular hyperintensity SCP, selective cerebral perfusion TAR, total arch replacement TEVAR, thoracic endovascular aortic repair WMH, white matter hyperintensity magnetic resonance imaging postoperative delirium total arch replacement white matter intensity
Impact of delirium on the outcome of stroke: a prospective, observational, cohort study	Rollo, E. Brunetti, V. Scala, I. Callea, A. Marotta, J. Vollono, C. Frisullo, G. Broccolini, A. Calabresi, P. Della Marca, G.	J Neurol	2022	Delirium Disability Mortality Outcome Prognosis Stroke
Association between non-English language and use of physical and chemical restraints among medical inpatients with delirium	Reppas-Rindlisbacher, C. Shin, S. Purohit, U. Verma, A. Razak, F. Rochon, P. Sheehan, K. Rawal, S.	J Am Geriatr Soc	2022
Sedation, analgesia, and delirium management in Portugal: a survey and point prevalence study	Paulino, M. C. Pereira, I. J. Costa, V. Neves, A. Santos, A. Teixeira, C. M. Coimbra, I. Fernandes, P. Bernardo, R. Póvoa, P. Granja, C.	Rev Bras Ter Intensiva	2022	Analgesia Analgesics, Opioid Cross-Sectional Studies Delirium/epidemiology Humans Hypnotics and Sedatives/therapeutic use Intensive Care Units Pain/drug therapy/epidemiology Portugal/epidemiology Prevalence
Acute kidney injury-associated delirium: a review of clinical and pathophysiological mechanisms	Pang, H. Kumar, S. Ely, E. W. Gezalian, M. M. Lahiri, S.	Crit Care	2022	Acute Kidney Injury Critical Illness Delirium Humans Risk Factors *Water-Electrolyte Imbalance
Delirium Development After Lung Transplantation: An Intraoperative Assessment	Ozay, H. Y. Bindal, M. Turkkan, S. Beyoglu, M. A. Yekeler, E. Turan, S.	Transplant Proc	2022
Delirium severity does not differ between medical and surgical intensive care units after adjusting for medication use	Ortiz, D. Lindroth, H. L. Braly, T. Perkins, A. J. Mohanty, S. Meagher, A. D. Khan, S. H. Boustani, M. A. Khan, B. A.	Sci Rep	2022	Activities of Daily Living Adolescent Adult Analgesics, Opioid/therapeutic use Benzodiazepines/therapeutic use Consciousness Disorders/complications Critical Care *Delirium/drug therapy/etiology Female Humans Intensive Care Units Male Middle Aged
Risk factors for postoperative delirium on oxygen delivery-guided perfusion	Mukaida, H. Matsushita, S. Minami, Y. Sato, G. Usuba, M. Kondo, R. Asai, T. Amano, A.	J Cardiothorac Surg	2022	Cardiopulmonary Bypass/adverse effects/methods Delirium/etiology/prevention & control Humans Oxygen Perfusion/adverse effects Postoperative Complications/etiology/prevention & control Retrospective Studies Risk Factors Cardiopulmonary bypass Goal directed perfusion Hemodilution Optimal perfusion Oxygen delivery
Identifying Medicare Beneficiaries With Delirium	Moura, Lmvr Zafar, S. Benson, N. M. Festa, N. Price, M. Donahue, M. A. Normand, S. L. Newhouse, J. P. Blacker, D. Hsu, J.	Med Care	2022
The development of a web-based app employing machine learning for delirium prevention in long-term care facilities in South Korea	Moon, K. J. Son, C. S. Lee, J. H. Park, M.	BMC Med Inform Decis Mak	2022	Delirium/diagnosis/prevention & control Humans Internet Long-Term Care Machine Learning Mobile Applications Republic of Korea Clinical decision support system Delirium Long-term care facility Mobile apps Rule-based prediction
Impact of Family Presence on Delirium in Critically Ill Patients: A Retrospective Cohort Study	Mohsen, S. Moss, S. J. Lucini, F. Krewulak, K. D. Stelfox, H. T. Niven, D. J. Sauro, K. M. Fiest, K. M.	Crit Care Med	2022
Serum levels of apolipoprotein A-I and E are associated with postoperative delirium: A post hoc analysis	Mietani, K. Hasegawa-Moriyama, M. Inoue, R. Ogata, T. Shimojo, N. Kurano, M. Yatomi, Y. Uchida, K. Sumitani, M.	Medicine (Baltimore)	2022	Aged Apolipoprotein A-I Biomarkers Delirium/diagnosis/etiology/psychology Humans Postoperative Complications/diagnosis Prospective Studies Risk Factors
Staff training and the use of rapid, accurate and user-friendly tools for delirium screening could improve the diagnosis of delirium in the elderly referred to the emergency department	Mazzola, P. Spedale, V.	Evid Based Nurs	2022	evidence-based nursing mental health nursing nursing research
Current practice of pharmacological treatment for hyperactive delirium in terminally ill cancer patients: results of a nationwide survey of Japanese palliative care physicians and liaison psychiatrists	Matsuda, Y. Morita, T. Oya, K. Tagami, K. Naito, A. S. Kashiwagi, H. Otani, H.	Jpn J Clin Oncol	2022	Antipsychotic Agents/therapeutic use Benzodiazepines/therapeutic use Delirium/drug therapy Haloperidol/therapeutic use Humans Japan Neoplasms/complications/drug therapy Palliative Care Physicians *Psychiatry Surveys and Questionnaires Terminally Ill antipsychotic cancer hyperactive delirium pharmacological treatment terminal delirium
Higher serum PGE2 is a predicative biomarker for postoperative delirium following elective orthopedic surgery in elderly patients	Mao, M. Wang, L. Y. Zhu, L. Y. Wang, F. Ding, Y. Tong, J. H. Sun, J. Sun, Q. Ji, M. H.	BMC Geriatr	2022	Aged Biomarkers Delirium/diagnosis/epidemiology/etiology Dinoprostone Humans Orthopedic Procedures/adverse effects Postoperative Complications/diagnosis/epidemiology/etiology Prospective Studies Risk Factors Biomarker Orthopedic surgery Pge2 Postoperative delirium
Effect of acute pain on the association between preoperative cognitive impairment and postoperative delirium: a secondary analysis of three trials	Ma, J. H. Liu, Y. F. Hong, H. Li, C. J. Cui, F. Mu, D. L. Wang, D. X.	Br J Anaesth	2022	cognitive dysfunction delirium mediation analysis postoperative complications postoperative pain
A systematic review of modified electroconvulsive therapy (ECT) to treat delirium	Lupke, K. Warren, N. Teodorczuk, A. Steele, S. Kolur, U. Wand, A. Robinson, G. Parker, S.	Acta Psychiatr Scand	2022	acute confusion delirium electroconvulsive therapy treatment
Incidence and interaction factors of delirium as an independent risk of mortality in elderly patients in the intensive units: a retrospective analysis from MIMIC-IV database	Liu, H. Zhao, Q. Liu, X. Hu, X. Wang, L. Zhou, F.	Aging Clin Exp Res	2022	Delirium Elderly patients Hemoglobin Mortality Sofa
The effect of neostigmine on postoperative delirium after colon carcinoma surgery: a randomized, double-blind, controlled trial	Liu, F. Lin, X. Lin, Y. Deng, X. Guo, Y. Wang, B. Dong, R. Bi, Y.	BMC Anesthesiol	2022	Adult Aged Aged, 80 and over Carcinoma Colon Delirium/epidemiology/etiology/prevention & control Double-Blind Method Humans Middle Aged Neostigmine/therapeutic use Postoperative Complications/epidemiology/prevention & control Retrospective Studies Colon carcinoma surgery Neostigmine Postoperative delirium Postoperative pulmonary complications Tof
Outcomes of postoperative delirium in patients undergoing cardiac surgery: A systematic review and meta-analysis	Lin, L. Zhang, X. Xu, S. Peng, Y. Li, S. Huang, X. Chen, L. Lin, Y.	Front Cardiovasc Med	2022	cardiac surgery meta-analysis mortality outcome postoperative delirium systematic review
Non-pharmacological delirium prevention practices among critical care nurses: a qualitative study	Liang, S. Chau, J. P. C. Lo, S. H. S. Zhao, J. Liu, W.	BMC Nurs	2022	Delirium Intensive care units Non-pharmacological delirium prevention practice Registered nurses
Effect of regional anesthesia on the postoperative delirium: A systematic review and meta-analysis of randomized controlled trials	Li, T. Dong, T. Cui, Y. Meng, X. Dai, Z.	Front Surg	2022	delirium general anesthesia meta—analysis pain regional anesthesia
Assessing Delirium at Hospital Discharge	Lepkowsky, C. M. Janklow, H. M.	Am J Geriatr Psychiatry	2022	Delirium assessment hospital discharge older adults
The Effects of Pain, Agitation, Delirium, Immobility, and Sleep Disruption Education on Novice Nurses in Adult Intensive Care Units	Lee, S. Y. Liu, C. Y. Wu, T. Y.	Healthcare (Basel)	2022	Padis adult intensive care unit clinical ladder education intervention novice nurse
Treatment of Positive Urine Cultures at End-of-Life and the Effect on Terminal Delirium Management	Latuga, N. M. Grant, P. C. Levy, K. Luczkiewicz, D. L.	Am J Hosp Palliat Care	2022	Anti-Bacterial Agents/therapeutic use Death Delirium/drug therapy Humans Palliative Care Retrospective Studies Urinary Tract Infections/drug therapy antibiotics antimicrobial delirium end-of-life hospice infection palliative terminal
Risk factors and effect of postoperative delirium on adverse surgical outcomes in older adults after elective abdominal cancer surgery in Taiwan	Lai, C. C. Liu, K. H. Tsai, C. Y. Hsu, J. T. Hsueh, S. W. Hung, C. Y. Chou, W. C.	Asian J Surg	2022	Cancer surgery Delirium Elderly Oncogeriatric patient Taiwan
A Quality Improvement Study on Delirium Awareness Day: In Pursuit of Missed Delirium Diagnoses	Koca, M. Öztürk, Y. Boğa, İ Bürkük, S. Eşme, M. Akyürek, Y. Şimşek, S. Aydın, D. D. Çiçek, F. Karabulut, E. Halil, M. Cankurtaran, M. Tanrıöver, M. D. Doğu, B. B.	J Gerontol Nurs	2022	Aged *Delirium/diagnosis/epidemiology Humans Mass Screening Prospective Studies Quality Improvement
Serum C-reactive protein adds predictive information for post-stroke delirium: The PROPOLIS study	Klimiec-Moskal, E. Slowik, A. Dziedzic, T.	Acta Psychiatr Scand	2022	Crp delirium prediction stroke
External validation and comparison of two delirium prediction models in patients admitted to the cardiac intensive care unit	Kim, S. E. Ko, R. E. Na, S. J. Chung, C. R. Choi, K. H. Kim, D. Park, T. K. Lee, J. M. Song, Y. B. Choi, J. O. Hahn, J. Y. Choi, S. H. Gwon, H. C. Yang, J. H.	Front Cardiovasc Med	2022	Early PREdiction of DELIRium PREdiction of DELIRium cardiac intensive care unit delirium prediction prediction model
Delirium and Cortical Complexity	Kim, H. Lee, U. C. Vlisides, P. E.	Delirium and Cortical Complexity	2022
Can Variables From the Electronic Health Record Identify Delirium at Bedside?	Khan, A. Heslin, K. Simpson, M. Malone, M. L.	J Patient Cent Res Rev	2022	delirium diagnosis disease prediction model electronic health record ethnoracial
Thoracic Paravertebral Block Ameliorates Postoperative Delirium in Geriatric Patients	Heng, L. Wang, M. Wang, M. Li, L. Zhu, S.	Thorac Cardiovasc Surg	2022	Aged Delirium/diagnosis/etiology/prevention & control Humans Nausea Pain, Postoperative/diagnosis/etiology/prevention & control Propofol/adverse effects *Pulmonary Atelectasis Remifentanil Treatment Outcome Vomiting
Relationship of sleep disturbance and postoperative delirium: a systematic review and meta-analysis	He, E. Dong, Y. Jia, H. Yu, L.	Gland Surg	2022	Postoperative delirium (PD) meta-analysis sleep disturbance systematic review
Acceptability of transdermal antipsychotic patches by patients who refuse oral medication and their effectiveness in preventing recurrence of delirium: a retrospective observational study	Hatta, K. Usui, C. Nakamura, H.	Int Clin Psychopharmacol	2022
Perioperative Hemodynamic Optimization in Patients at Risk for Delirium - A Randomized-Controlled Trial	Fuest, K. E. Servatius, A. Ulm, B. Schaller, S. J. Jungwirth, B. Blobner, M. Schmid, S.	Front Med (Lausanne)	2022	frailty goal-directed hemodynamic monitoring goal-directed therapy outcome post-operative delirium
Proposing a Scientific and Technological Approach to the Summaries of Clinical Issues of Inpatient Elderly with Delirium: A Viewpoint	Frisardi, V. Nicolini, M. Cautero, N. Ghirardelli, R. Davolio, F. Haouili, M. Barani, M.	Healthcare (Basel)	2022	delirium disease management healthcare patient care management technology telemedicine
Incidence of Drug-Induced Delirium During Treatment With Antidepressants or Antipsychotics: A Drug Surveillance Report of German-Speaking Countries Between 1993 and 2016	Friedrich, M. E. Grohmann, R. Rabl, U. Winkler, D. Konstantinidis, A. Engel, R. Seifert, J. Toto, S. Stübner, S. Frey, R. Kasper, S.	Int J Neuropsychopharmacol	2022	Adverse Drug Reaction Reporting Systems Amitriptyline Antidepressive Agents/adverse effects Antipsychotic Agents/adverse effects Clozapine Delirium/chemically induced/drug therapy/epidemiology Humans Incidence Muscarinic Antagonists Psychoses, Substance-Induced Adverse drug reactions antidepressants antipsychotics delirium drug surveillance
The inter-relationship between delirium and dementia: the importance of delirium prevention	Fong, T. G. Inouye, S. K.	Nat Rev Neurol	2022
Five-Year Outcomes After Implementing a Pain, Agitation, and Delirium Protocol in a Mixed Intensive Care Unit	Fish, J. T. Baxa, J. T. Draheim, R. R. Willenborg, M. J. Mills, J. C. Sticht, L. A. Hankwitz, J. L. Wells, J. A. Jung, H. S.	J Intensive Care Med	2022	Adult Analgesics/therapeutic use *Delirium/drug therapy Humans Hypnotics and Sedatives/therapeutic use Intensive Care Units Length of Stay Pain/drug therapy Respiration, Artificial Retrospective Studies analgesics cost analysis costs critical care hypnotics and sedatives protocol
Improving Delirium Assessments in Vanderbilt Pediatric and Pediatric Cardiovascular Intensive Care Units	Eken, H. N. Betters, K. A. Fuchs, D. C. Smith, H. A. B. Williams, S. R.	Pediatr Qual Saf	2022
Outcomes in Post-operative Delirium Following Bowel Resection: A Single Center Retrospective Review	Desrochers, R. M. Lynch, L. J. Gates, J. D. Ricaurte, D. Wade, J. T. Dicks, R. S. Keating, J. J.	J Surg Res	2022	Bowel Delirium Elective Emergency Mortality Resection
Efficacy and Safety of Remimazolam Besylate versus Dexmedetomidine for Sedation in Non-Intubated Older Patients with Agitated Delirium After Orthopedic Surgery: A Randomized Controlled Trial	Deng, Y. Qin, Z. Wu, Q. Liu, L. Yang, X. Ju, X. Zhang, Y. Liu, L.	Drug Des Devel Ther	2022	Benzodiazepines Delirium/drug therapy Dexmedetomidine/adverse effects Humans Hypnotics and Sedatives/adverse effects *Orthopedic Procedures agitation delirium dexmedetomidine older adult orthopedics remimazolam besylate
Delirium, changes in cognitive function, and risk of diagnosed dementia after kidney transplantation	Chu, N. M. Bae, S. Chen, X. Ruck, J. Gross, A. L. Albert, M. Neufeld, K. J. Segev, D. L. McAdams-DeMarco, M. A.	Am J Transplant	2022	clinical research/practice cognitive function delirium epidemiology health services and outcomes research kidney disease kidney transplant kidney transplantation/nephrology mental health neurology
Bispectral Index (BIS) Monitoring and Postoperative Delirium in Elderly Patients Undergoing Surgery: A Systematic Review and Meta-Analysis With Trial Sequential Analysis	Chew, W. Z. Teoh, W. Y. Sivanesan, N. Loh, P. S. Shariffuddin,, II Ti, L. K. Ng, K. T.	J Cardiothorac Vasc Anesth	2022	Bis elderly meta-analysis postoperative cognitive dysfunction postoperative delirium systematic review
Delirium prevalence in geriatric emergency department patients: A systematic review and meta-analysis	Chen, F. Liu, L. Wang, Y. Liu, Y. Fan, L. Chi, J.	Am J Emerg Med	2022	Aged *Delirium/diagnosis/epidemiology Emergency Service, Hospital Humans Mass Screening Prevalence Delirium Meta-analysis Older adults
Improving quantification of anticholinergic burden using the Anticholinergic Effect on Cognition Scale - a healthcare improvement study in a geriatric ward setting	Balasundaram, B. Ang, W. S. T. Stewart, R. Bishara, D. Ooi, C. H. Li, F. Akram, F. Eu Kwek, A. B.	Australas Psychiatry	2022	Aged Cholinergic Antagonists/adverse effects Cognition Cognition Disorders Delivery of Health Care Hospitals Humans anticholinergic burden scales anticholinergic drugs anticholinergic effect on cognition scale delirium dementia
The Association of Selective Serotonin Reuptake Inhibitors With Delirium in Critically Ill Adults: A Secondary Analysis of the Bringing to Light the Risk Factors and Incidence of Neuropsychologic Dysfunction in ICU Survivors ICU Study	Austin, C. A. Yi, J. Lin, F. C. Pandharipande, P. Ely, E. W. Busby-Whitehead, J. Carson, S. S.	Crit Care Explor	2022	delirium intensive care unit outcomes neurophysiology neurotransmitters selective serotonin reuptake inhibitors interest.
Parental Education and Delirium Risk after Surgery in Older Adults	Arias, F. Chen, F. Shiff, H. Marcantonio, E. R. Jones, R. N. Schmitt, E. M. Metzger, E. Fong, T. G. Travison, T. G. Inouye, S. K.	Clin Gerontol	2022	Childhood socioeconomic status delirium social determinants of health
Informing the standardising of care for prolonged stay patients in the ICU: A scoping review of quality improvement tools	Allum, L. Apps, C. Pattison, N. Connolly, B. Rose, L.	Intensive Crit Care Nurs	2022	Bundle Care standardisation Checklist Critical care Persistent or chronic critical illness Quality improvement
Monitoring of nighttime EEG slow-wave activity during dexmedetomidine infusion in patients with hyperactive ICU delirium: An observational pilot study	Ala-Kokko, T. Erikson, K. Koskenkari, J. Laurila, J. Kortelainen, J.	Acta Anaesthesiol Scand	2022	C-trend Rcsq sleep
Development of a Delirium Risk Predication Model among ICU Patients in Oman	Al-Hoodar, R. K. Lazarus, E. R. Alomari, O. Alzaabi, O.	Anesthesiol Res Pract	2022
Comparison Between Deltascan Single Channel Electroencephalography (EEG), Confusion Assessment Method-Intensive Care Unit (CAM-ICU) Score and Clinical Assessment in Diagnosing Delirium in Intubated Patients in the Intensive Care Unit	Aben, J. Pouwels, S. Oldenbeuving, A.	Cureus	2022	cam-icu complications delirium electroencephalography intensive care monitoring
A Cross-Sectional Survey on the Clinical Management of Emergence Delirium in Adults: Knowledge, Attitudes, and Practice in Mainland China	Yuan, Y. Lei, B. Li, Z. Wang, X. Zhao, H. Gao, M. Xue, Y. Zhang, W. Xiao, R. Meng, X. Zheng, H. Zhang, J. Wang, G. Guo, X.	Brain Sci	2022	Pacu anesthesia nurse emergence delirium
Development and Validation of a Nomogram for Predicting Postoperative Delirium in Patients With Elderly Hip Fracture Based on Data Collected on Admission	Yang, Y. Wang, T. Guo, H. Sun, Y. Cao, J. Xu, P. Cai, Y.	Front Aging Neurosci	2022	albumin chronic obstructive pulmonary disease dementia elderly hip fracture nomogram postoperative delirium prediction model
Preoperative Inflammatory Markers and the Risk of Postoperative Delirium in Patients Undergoing Lumbar Spinal Fusion Surgery	Yang, J. S. Lee, J. J. Kwon, Y. S. Kim, J. H. Sohn, J. H.	J Clin Med	2022	CRP-to-albumin ratio monocyte-to-lymphocyte ratio neutrophil-to-lymphocyte ratio postoperative delirium spine surgery
An association between cancer type and delirium incidence in Japanese elderly patients: A retrospective longitudinal study	Yamato, K. Ikeda, A. Endo, M. Filomeno, R. Kiyohara, K. Inada, K. Nishimura, K. Tanigawa, T.	Cancer Med	2022	cancer delirium longitudinal study
Increased Direct Current-Electroencephalography Shifts During Induction of Anesthesia in Elderly Patients Developing Postoperative Delirium	Windmann, V. Dreier, J. P. Major, S. Spies, C. Lachmann, G. Koch, S.	Front Aging Neurosci	2022	dc-eeg anesthesia induction blood–brain barrier direct current EEG electroencephalography hyperventilation *postoperative delirium (POD)