What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Exercise for acutely hospitalised older medical patients
- Authors
- Hartley, P. Keating, J. L. Jeffs, K. J. Raymond, M. J. Smith, T. O
- Year
- 2022
- Journal
- Cochrane Database Syst Rev
- Abstract
BACKGROUND: Approximately 30% of hospitalised older adults experience hospital-associated functional decline. Exercise interventions that promote in-hospital activity may prevent deconditioning and thereby maintain physical function during hospitalisation. This is an update of a Cochrane Review first published in 2007. OBJECTIVES: To evaluate the benefits and harms of exercise interventions for acutely hospitalised older medical inpatients on functional ability, quality of life (QoL), participant global assessment of success and adverse events compared to usual care or a sham-control intervention. SEARCH METHODS: We used standard, extensive Cochrane search methods. The latest search date was May 2021. SELECTION CRITERIA: We included randomised or quasi-randomised controlled trials evaluating an in-hospital exercise intervention in people aged 65 years or older admitted to hospital with a general medical condition. We excluded people admitted for elective reasons or surgery. DATA COLLECTION AND ANALYSIS: We used standard Cochrane methods. Our major outcomes were 1. independence with activities of daily living; 2. functional mobility; 3. new incidence of delirium during hospitalisation; 4. QoL; 5. number of falls during hospitalisation; 6. medical deterioration during hospitalisation and 7. participant global assessment of success. Our minor outcomes were 8. death during hospitalisation; 9. musculoskeletal injuries during hospitalisation; 10. hospital length of stay; 11. new institutionalisation at hospital discharge; 12. hospital readmission and 13. walking performance. We used GRADE to assess certainty of evidence for each major outcome. We categorised exercise interventions as: rehabilitation-related activities (interventions designed to increase physical activity or functional recovery, but did not follow a specified exercise protocol); structured exercise (interventions that included an exercise intervention protocol but did not include progressive resistance training); and progressive resistance exercise (interventions that included an element of progressive resistance training). MAIN RESULTS: We included 24 studies (nine rehabilitation-related activity interventions, six structured exercise interventions and nine progressive resistance exercise interventions) with 7511 participants. All studies compared exercise interventions to usual care; two studies, in addition to usual care, used sham interventions. Mean ages ranged from 73 to 88 years, and 58% of participants were women. Several studies were at high risk of bias. The most common domain assessed at high risk of bias was measurement of the outcome, and five studies (21%) were at high risk of bias arising from the randomisation process. Exercise may have no clinically important effect on independence in activities of daily living at discharge from hospital compared to controls (16 studies, 5174 participants; low-certainty evidence). Five studies used the Barthel Index (scale: 0 to 100, higher scores representing greater independence). Mean scores at discharge in the control groups ranged from 42 to 96 points, and independence in activities of daily living was 1.8 points better (0.43 worse to 4.12 better) with exercise compared to controls. The minimally clinical important difference (MCID) is estimated to be 11 points. We are uncertain regarding the effect of exercise on functional mobility at discharge from the hospital compared to controls (8 studies, 2369 participants; very low-certainty evidence). Three studies used the Short Physical Performance Battery (SPPB) (scale: 0 to 12, higher scores representing better function) to measure functional mobility. Mean scores at discharge in the control groups ranged from 3.7 to 4.9 points on the SPPB, and the estimated effect of the exercise interventions was 0.78 points better (0.02 worse to 1.57 better). A change of 1 point on the SPPB represents an MCID. We are uncertain regarding the effect of exercise on the incidence of delirium during hospitalisation compared to controls (7 trials, 2088 participants; very low-certainty evidence). The incidence of delirium during hospitalisation was 88/1091 (81 per 1000) in the control group compared with 70/997 (73 per 1000; range 47 to 114) in the exercise group (RR 0.90, 95% CI 0.58 to 1.41). Exercise interventions may result in a small clinically unimportant improvement in QoL at discharge from the hospital compared to controls (4 studies, 875 participants; low-certainty evidence). Mean QoL on the EuroQol 5 Dimensions (EQ-5D) visual analogue scale (VAS) (scale: 0 to 100, higher scores representing better QoL) ranged between 48.9 and 64.7 in the control group at discharge from the hospital, and QoL was 6.04 points better (0.9 better to 11.18 better) with exercise. A change of 10 points on the EQ-5D VAS represents an MCID. No studies measured participant global assessment of success. Exercise interventions did not affect the risk of falls during hospitalisation (moderate-certainty evidence). The incidence of falls was 31/899 (34 per 1000) in the control group compared with 31/888 (34 per 1000; range 20 to 57) in the exercise group (RR 0.99, 95% CI 0.59 to 1.65). We are uncertain regarding the effect of exercise on the incidence of medical deterioration during hospitalisation (very low-certainty evidence). The incidence of medical deterioration in the control group was 101/1417 (71 per 1000) compared with 96/1313 (73 per 1000; range 44 to 120) in the exercise group (RR 1.02, 95% CI 0.62 to 1.68). Subgroup analyses by different intervention categories and by the use of a sham intervention were not meaningfully different from the main analyses. AUTHORS’ CONCLUSIONS: Exercise may make little difference to independence in activities of daily living or QoL, but probably does not result in more falls in older medical inpatients. We are uncertain about the effect of exercise on functional mobility, incidence of delirium and medical deterioration. Certainty of evidence was limited by risk of bias and inconsistency. Future primary research on the effect of exercise on acute hospitalisation could focus on more consistent and uniform reporting of participant’s characteristics including their baseline level of functional ability, as well as exercise dose, intensity and adherence that may provide an insight into the reasons for the observed inconsistencies in findings.
- PMID
- Keywords
Aged
Aged, 80 and over
Female
Humans
Male
Activities of Daily Living
*Delirium/epidemiology
Exercise
*Quality of Life
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Different Sedation Strategies in Older Patients Receiving Spinal Anesthesia for Hip Surgery on Postoperative Delirium: A Randomized Clinical Trial | Zhu, S. Liu, Y. Wang, X. Wang, L. Li, J. Xue, X. Li, Z. Liu, J. Liu, X. Zhao, S. | Drug Des Devel Ther | 2023 |
Humans, Aged, Propofol/adverse effects, Emergence Delirium, Hypnotics and Sedatives/adverse effects, Dexmedetomidine/adverse effects, Anesthesia, Spinal/adverse effects, Delirium/etiology, Postoperative Complications/epidemiology, anesthetics, hip surgery, propofol, spinal anesthesia |
| Frailty and post-operative delirium influence on functional status in patients with hip fracture: the GIOG 2.0 study | Gandossi, C. M. Zambon, A. Ferrara, M. C. Tassistro, E. Castoldi, G. Colombo, F. Mussi, C. Martini, E. Sergi, G. Coin, A. Zatti, G. Trevisan, C. Volpato, S. Ungar, A. Bellelli, G. | Aging Clin Exp Res | 2023 |
Humans |
| Associations between Alzheimer's disease biomarkers and postoperative delirium or cognitive dysfunction: A meta-analysis and trial sequential analysis of prospective clinical trials | Geng, J. Zhang, Y. Chen, H. Shi, H. Wu, Z. Chen, J. Luo, F. | Eur J Anaesthesiol | 2023 | |
| Delirium in oncological palliative care and clinical cardiology units: A comparative analysis | Grisales, E. S. Higuita, A. M. Correa, M. E. Gómez, J. J. V. González, C. P. Daveloza, A. K. Vásquez, J. G. F. | Palliat Support Care |
Humans |
|
| Risk Factors and Associated Outcomes of Postoperative Delirium After Open Abdominal Aortic Aneurysm Repair | Gutierrez, R. D. Smith, E. J. T. Matthay, Z. A. Gasper, W. J. Hiramoto, J. S. Conte, M. S. Finlayson, E. Walter, L. C. Iannuzzi, J. C. | J Vasc Surg | 2023 |
abdominal aortic aneurysm (AAA) |
| Effect of preoperative sleep disorders on delirium in proximal femoral surgery patients aged 60 or older | Han, F. Liu, X. Huang, H. Chu, H. Feng, W. | BMC Anesthesiol | 2023 |
Humans |
| Electroencephalogram measured functional connectivity for delirium detection: a systematic review | Hanna, A. Jirsch, J. Alain, C. Corvinelli, S. Lee, J. S. | Front Neurosci | 2023 |
Eeg |
| Development and evaluation of a concise nurse-driven non-pharmacological delirium reduction workflow for hospitalized patients: An interrupted time series study | Harrison, J. D. Rathfon, M. Binford, S. Miranda, J. Oreper, S. Holt, B. Rogers, S. E. | Geriatr Nurs | 2023 |
Delirium |
| Predicting postoperative delirium after cardiovascular surgeries from preoperative portable electroencephalography oscillations | Hata, M. Miyazaki, Y. Nagata, C. Masuda, H. Wada, T. Takahashi, S. Ishii, R. Miyagawa, S. Ikeda, M. Ueno, T. | Front Psychiatry | 2023 |
Eeg |
| Lower alpha frequency of intraoperative frontal EEG is associated with postoperative delirium: A secondary propensity-matched analysis | Hight, D. Ehrhardt, A. Lersch, F. Luedi, M. M. Stüber, F. Kaiser, H. A. | J Clin Anesth | 2023 |
Alpha rhythm |
| Inflammatory and nutritional markers predict the risk of post-operative delirium in elderly patients following total hip arthroplasty | Hu, W. Song, Z. Shang, H. Wang, J. Hao, Y. | Front Nutr | 2023 |
inflammatory markers |
| Evaluation of brain nerve function in ICU patients with Delirium by deep learning algorithm-based resting state MRI | Huang, X. Jiang, R. Peng, S. Wei, Y. Hu, X. Chen, J. Lian, W. | Open Life Sci | 2023 |
brain nerve function |
| Prevention and treatment of traumatic brain injury-related delirium: a systematic review | Huang, Y. Q. Weiss, S. Gros, P. Wong, E. Piché, P. P. Vyas, M. V. Tam, A. K. H. Watt, J. A. | J Neurol | 2023 |
Humans |
| The Efficacy of Dexmedetomidine alone or with Melatonin on Delirium after Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial | Javaherforooshzadeh, F. Babazadeh Dezfoli, A. Saki Malehi, A. Gholizadeh, B. | Anesth Pain Med | 2023 |
Cardiac Surgery |
| Cerebral autoregulation-based mean arterial pressure targets and delirium in critically ill adults without brain injury: a retrospective cohort study | Khan, J. M. Shore, A. Lee, K. F. H. Wood, M. D. Maslove, D. M. Hunt, M. Georgescu, I. Muscedere, J. Boyd, J. G. | Can J Anaesth | 2023 |
cerebral autoregulation |
| Clinical Features of Delirium among Patients in the Intensive Care Unit According to Motor Subtype Classification: A Retrospective Longitudinal Study | Kim, J. Oh, J. Ahn, J. S. Chung, K. Kim, M. K. Shin, C. S. Park, J. Y. | Yonsei Med J | 2023 |
Humans |
| The Efficacy of Ramelteon to Prevent Postoperative Delirium After General Anesthesia in the Elderly: A Double-Blind, Randomized, Placebo-Controlled Trial | Kinouchi, M. Mihara, T. Taguri, M. Ogura, M. | Am J Geriatr Psychiatry | 2023 |
Aged |
| Association of general anesthesia exposure with risk of postoperative delirium in patients receiving transcatheter aortic valve replacement: a meta-analysis and systematic review | Ko, C. C. Hung, K. C. Chang, Y. P. Liu, C. C. Cheng, W. J. Wu, J. Y. Li, Y. Y. Lin, T. C. Sun, C. K. | Sci Rep | 2023 |
Delirium is a heterogeneous and detrimental mental condition often seen in older, hospitalized patients and is currently hard to predict. In this study, we leverage large-scale, real- world data using the electronic health records (EHR) to identify two cohorts comprised of 7,492 UCSF patients and 19,417 UC health system patients (excluding UCSF patients) with an inpatient delirium diagnosis and the same number of propensity score-matched control patients without delirium. We found significant associations between comorbidities or laboratory test values and an inpatient delirium diagnosis which were validated independently. Most of these associations were those previously-identified as risk factors for delirium, including metabolic abnormalities, mental health diagnoses, and infections. Some of the associations were sex- specific, including those related to dementia subtypes and infections. We further explored the diagnostic associations with anemia and bipolar disorder by conducting longitudinal analyses from the time of first diagnosis of the risk factor to development of delirium demonstrating a significant relationship across time. Finally, we show that an inpatient delirium diagnosis leads to dramatic increases in mortality outcome across both cohorts. These results demonstrate the powerful application of leveraging EHR data to shed insights into prior diagnoses and laboratory test values that could help predict development of inpatient delirium and emphasize the importance of considering patient demographic characteristics including documented sex when making these assessments. ONE SENTENCE SUMMARY: Longitudinal analysis of electronic health record data reveals associations between inpatient delirium, comorbidities, and mortality. |
| Sex-stratified phenotyping of comorbidities associated with an inpatient delirium diagnosis using real world data | Kodama, L. Woldemariam, S. Tang, A. Li, Y. Oskotsky, T. Raphael, E. Sirota, M. | medRxiv | 2023 |
Delirium is a heterogeneous and detrimental mental condition often seen in older, hospitalized patients and is currently hard to predict. In this study, we leverage large-scale, real- world data using the electronic health records (EHR) to identify two cohorts comprised of 7,492 UCSF patients and 19,417 UC health system patients (excluding UCSF patients) with an inpatient delirium diagnosis and the same number of propensity score-matched control patients without delirium. We found significant associations between comorbidities or laboratory test values and an inpatient delirium diagnosis which were validated independently. Most of these associations were those previously-identified as risk factors for delirium, including metabolic abnormalities, mental health diagnoses, and infections. Some of the associations were sex- specific, including those related to dementia subtypes and infections. We further explored the diagnostic associations with anemia and bipolar disorder by conducting longitudinal analyses from the time of first diagnosis of the risk factor to development of delirium demonstrating a significant relationship across time. Finally, we show that an inpatient delirium diagnosis leads to dramatic increases in mortality outcome across both cohorts. These results demonstrate the powerful application of leveraging EHR data to shed insights into prior diagnoses and laboratory test values that could help predict development of inpatient delirium and emphasize the importance of considering patient demographic characteristics including documented sex when making these assessments. ONE SENTENCE SUMMARY: Longitudinal analysis of electronic health record data reveals associations between inpatient delirium, comorbidities, and mortality. |
| Comparison of the effectiveness of delirium evaluation tools in intensive care patients: pre-deliric versions 1 and 2, E-pre-deliric and ICDSC | Kucuk, O. Memis, D. Inal, M. T. Turan, F. N. Memis, I. | Eur Rev Med Pharmacol Sci | 2023 |
Male |
| New-onset delirium during hospitalization in older adults: incidence and risk factors | Lami Pereira, R. Bojanini Molina, L. Wilger, K. Hedges, M. S. Tolaymat, L. Haga, C. Walker, A. Gillis, M. Yin, M. Dawson, N. L. | Hosp Pract (1995) | 2023 |
Humans |
| The Potential Value of Systemic Inflammation Response Index on Delirium After Hip Arthroplasty Surgery in Older Patients: A Retrospective Study | Lu, W. Lin, S. Wang, C. Jin, P. Bian, J. | Int J Gen Med | 2023 |
geriatric |
| Incidence of delirium in older people with cancer: Systematic review and meta-analysis | Martínez-Arnau, F. M. Buigues, C. Pérez-Ros, P. | Eur J Oncol Nurs | 2023 |
Cancer |
| Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) for the diagnosis of delirium in adults in critical care settings | Miranda, F. Gonzalez, F. Plana, M. N. Zamora, J. Quinn, T. J. Seron, P. | Cochrane Database Syst Rev | 2023 |
Adult |
| Exploration of key drug target proteins highlighting their related regulatory molecules, functional pathways and drug candidates associated with delirium: evidence from meta-data analyses | Mosharaf, M. P. Alam, K. Gow, J. Mahumud, R. A. | BMC Geriatr | 2023 |
Humans |
| Development of postoperative delirium prediction models in patients undergoing cardiovascular surgery using machine learning algorithms | Nagata, C. Hata, M. Miyazaki, Y. Masuda, H. Wada, T. Kimura, T. Fujii, M. Sakurai, Y. Matsubara, Y. Yoshida, K. Miyagawa, S. Ikeda, M. Ueno, T. | Sci Rep | 2023 |
delirium, postoperative, machine learning, cardiovascular, hospital |
| EEG microstate quantifiers and state space descriptors during anaesthesia in patients with postoperative delirium: a descriptive analysis | Neuner, B. Wolter, S. McCarthy, W. J. Spies, C. Cunningham, C. Radtke, F. M. Franck, M. Koenig, T. | Brain Commun | 2023 |
EEG microstates |
| Efficacy and Safety of Risperidone in Patients With Delirium: The RIDDLE Pilot Study | Nguyen, P. V. Vu, T. T. M. | Aust Crit CareJ Clin Psychopharmacol | 2023 |
delirium, pilot study, risperidone, delirium rating scale, hospital |
| Intensive care unit nurses' perception of three different methods for delirium screening: A survey (DELIS-3) | Nielsen, A. H. Larsen, L. K. Collet, M. O. Lehmkuhl, L. Bekker, C. Jensen, J. F. Laerkner, E. Nielsen, T. A. Rossen, B. S. Thorn, L. Laursen, E. Fischer, S. Villumsen, M. Shiv, L. H. Høgh, M. Rahr, M. N. Svenningsen, H. | Aust Crit Care | 2023 |
Humans |
| Melatonin and Melatonin Agonists for Prevention of Delirium in the Cardiac Surgical ICU: A Meta-analysis | Niyogi, S. G. Naskar, C. Singh, A. Kumar, B. Grover, S. | Indian J Crit Care Med | 2023 |
Cardiac critical care |
| Association between Neuron-Specific Enolase, Memory Function, and Postoperative Delirium after Transfemoral Aortic Valve Replacement | Nübel, J. Buhre, C. Hoffmeister, M. Oess, S. Labrenz, O. Jost, K. Hauptmann, M. Schön, J. Fritz, G. Butter, C. Haase-Fielitz, A. | J Cardiovasc Dev Dis | 2023 |
Tavr |
| A retrospective, cross-sectional analysis of delirium in burn injury compared to other surgical specialities | O'Brien, A. Hopkins, J. Boardman, G. Stanley, G. Daly, P. Martin, L. Wood, F. | Burns | 2023 |
Humans |
| Postoperative Use of the Muscle Relaxants Baclofen and/or Cyclobenzaprine Associated With an Increased Risk of Delirium Following Lumbar Fusion | Perez, E. A. Ray, E. Gold, C. J. Park, B. J. Piscopo, A. Carnahan, R. M. Banks, M. Sanders, R. D. Olinger, C. R. Mueller, R. N. Woodroffe, R. W. | Spine (Phila Pa 1976) | 2023 |
Humans |
| Extracellular Vesicles as Possible Plasma Markers and Mediators in Patients with Sepsis-Associated Delirium-A Pilot Study | Plaschke, K. Brenner, T. Fiedler, M. O. Hölle, T. von der Forst, M. Wolf, R. C. Kopitz, J. Gebert, J. Weigand, M. A. | Int J Mol Sci | 2023 |
Humans |
| Rest-activity patterns associated with delirium in patients with intracerebral hemorrhage | Reznik, M. E. Mintz, N. Moody, S. Drake, J. Margolis, S. A. Rudolph, J. L. LaBuzetta, J. N. Kamdar, B. B. Jones, R. N. | J Neurol Sci | 2023 |
Humans |
| Development and validation of delirium prediction models for noncardiac surgery patients | Rössler, J. Shah, K. Medellin, S. Turan, A. Ruetzler, K. Singh, M. Sessler, D. I. Maheshwari, K. | J Pain Palliat Care Pharmacother | 2023 |
Anesthesia |
| Effects of Opioids, Steroids, Benzodiazepines, Anticholinergics, and Antihistamines on the Efficacy of Antipsychotics for Treating Delirium in End-of-Life Adult Patients Undergoing Palliative Care | Sato, J. Tanaka, R. | J Pain Palliat Care Pharmacother | 2023 |
Humans |
| Clinical Prediction Models for Hospital-Induced Delirium Using Structured and Unstructured Electronic Health Record Data: Protocol for a Development and Validation Study | Ser, S. E. Shear, K. Snigurska, U. A. Prosperi, M. Wu, Y. Magoc, T. Bjarnadottir, R. I. Lucero, R. J. | JMIR Res Protoc | 2023 |
big data |
| A Prospective Randomized Study of the Herbal Medicine Yokukansan for Preventing Delirium After Gastrointestinal Cancer Surgery | Tanio, A. Yamamoto, M. Uejima, C. Tada, Y. Yamanashi, T. Matsuo, R. Miura, A. Kajitani, N. Nishiguchi, T. Iwata, M. Fujiwara, Y. | Yonago Acta Med | 2023 |
gastrointestinal cancer |
| A protocol of an international validation study to assess the clinical accuracy of the eDIS-ICU delirium screening tool | Tronstad, O. Patterson, S. Sutt, A. L. Pearse, I. Hay, K. Liu, K. Sato, K. Koga, Y. Matsuoka, A. Hongo, T. Rätsep, I. Fraser, J. F. Flaws, D. | Aust Crit Care | 2023 |
Humans |
| Anaesthesia-related cognitive dysfunction following cardiothoracic surgery in late middle-age and younger adults: A scoping review | Varpaei, H. A. Robbins, L. B. Ling, J. Lehto, R. H. Bender, C. M. | Nurs Crit Care | 2023 |
anaesthesia |
| Long-term mortality of critically ill patients with cancer and delirium who survived to discharge: a retrospective cohort study | Vizzacchi, B. A. Pezzini, T. R. de Souza, J. M. Caruso, P. Nassar, A. P., Jr. | Can J Anaesth | 2023 |
Adult |
| The effect of anesthetic depth on postoperative delirium in older adults: a systematic review and meta-analysis | Wang, Y. Zhu, H. Xu, F. Ding, Y. Zhao, S. Chen, X. | BMC Geriatr | 2023 |
Humans |
| Unveiling the nexus of postoperative fever and delirium in cardiac surgery: identifying predictors for enhanced patient care | Wang, Y. P. Shen, B. B. Zhu, C. C. Li, L. Lu, S. Wang, D. J. Jin, H. Liu, Q. Wang, Z. Y. Ge, M. | Front Cardiovasc Med | 2023 |
Cpb |
| Long-term cognitive impairment after probable delirium in long-term care residents: A population-based retrospective cohort study | Webber, C. Milani, C. Pugliese, M. Lawlor, P. G. Bush, S. H. Watt, C. Casey, G. Knoefel, F. Thavorn, K. Momoli, F. Tanuseputro, P. | J Am Geriatr Soc | 2023 |
cognitive decline |
| Delirium Due to Potentially Avoidable Hospitalizations Among Older Adults | Whittington, C. Skains, R. M. Zhang, Y. Osborne, J. D. O'Leary, T. Freeman, H. B. Martin, R. C. Vickers, J. K. Flood, K. L. Markland, A. D. Buford, T. W. Brown, C. J. Kennedy, R. E. | J Gerontol A Biol Sci Med Sci | 2023 |
ambulatory care sensitive conditions |
| Quantitative electroencephalography predicts postoperative delirium in cardiac surgical patients after cardiopulmonary bypass: a prospective observational study | Xue, Y. Liu, W. Su, L. He, H. Chen, H. Long, Y. | Front Med (Lausanne) | 2023 |
cardiopulmonary bypass |
| Natural language processing to assess the epidemiology of delirium-suggestive behavioural disturbances in critically ill patients | Young, M. Holmes, N. Robbins, R. Marhoon, N. Amjad, S. Neto, A. S. Bellomo, R. | Crit Care Resusc | 2021 |
Background: There is no gold standard approach for delirium diagnosis, making the assessment of its epidemiology difficult. Delirium can only be inferred though observation of behavioural disturbance and described with relevant nouns or adjectives. Objective: We aimed to use natural language processing (NLP) and its identification of words descriptive of behavioural disturbance to study the epidemiology of delirium in critically ill patients. Study design: Retrospective study using data collected from the electronic health records of a university-affiliated intensive care unit (ICU) in Melbourne, Australia. Participants: 12 375 patients Intervention: Analysis of electronic progress notes. Identification using NLP of at least one of a list of words describing behavioural disturbance within such notes. Results: We analysed 199 648 progress notes in 12 375 patients. Of these, 5108 patients (41.3%) had NLP-diagnosed behavioural disturbance (NLP-Dx-BD). Compared with those who did not have NLP-Dx-DB, these patients were older, more severely ill, and likely to have medical or unplanned admissions, neurological diagnosis, chronic kidney or liver disease and to receive mechanical ventilation and renal replacement therapy (P < 0.001). The unadjusted hospital mortality for NLP-Dx-BD patients was 14.1% versus 9.6% for patients without NLP-Dx-BD. After adjustment for baseline characteristics and illness severity, NLP-Dx-BD was not associated with increased risk of death (odds ratio [OR], 0.94; 95% CI, 0.80-1.10); a finding robust to multiple sensitivity, subgroups and time of observation subcohort analyses. In mechanically ventilated patients, NLP-Dx-BD was associated with decreased hospital mortality (OR, 0.80; 95% CI, 0.65-0.99) after adjustment for baseline severity of illness and year of admission. Conclusions: NLP enabled rapid assessment of large amounts of data identifying a population of ICU patients with typical high risk characteristics for delirium. Moreover, this technique enabled identification of previously poorly understood associations. Further investigations of this technique appear justified. |
| Association between intraoperative mean arterial pressure variability and postoperative delirium after hip fracture surgery: a retrospective cohort study | Zhang, C. Song, Y. Wu, X. Miao, R. Lou, J. Ma, Y. Li, M. Mi, W. Cao, J. | BMC Geriatr | 2023 |
Aged |
| Impact of Clinical Decision Support System Assisted prevention and management for Delirium on guideline adherence and cognitive load among Intensive Care Unit nurses (CDSSD-ICU): Protocol of a multicentre, cluster randomized trial | Zhang, S. Ding, S. Cui, W. Li, X. Wei, J. Wu, Y. | Int J Nurs Stud | 2023 |
Humans |
| Non-pharmacological interventions to prevent and treat delirium in older people: An overview of systematic reviews | Zhao, Q. Liu, S. Zhao, H. Dong, L. Zhu, X. Liu, J. | Int J Nurs Stud | 2023 |
Humans |
| Online interpretable dynamic prediction models for postoperative delirium after cardiac surgery under cardiopulmonary bypass developed based on machine learning algorithms: A retrospective cohort study | Zhao, X. Li, J. Xie, X. Fang, Z. Feng, Y. Zhong, Y. Chen, C. Huang, K. Ge, C. Shi, H. Si, Y. Zou, J. | J Psychosom Res | 2023 |
Cardiac surgery |
| Dementia and Postoperative Delirium in Surgical Hip Fracture Patients: Unveiling Contrasting Risk Factors and Implications | Zhao, Y. Alderden, J. Missbrenner, N. | J Gerontol Nurs | 2023 |
Humans |
| Diagnostic accuracy of the Family Confusion Assessment Method for delirium detection: A systematic review and meta-analysis | Zhou, C. Wang, H. Wang, L. Zhou, Y. Wu, Q. | J Am Geriatr Soc | 2023 |
Fam-cam |
| The effects of a multidisciplinary pathway for perioperative management of patients with hip fracture | Ackermann, L. L. Schwenk, E. S. Li, C. J. Vaile, J. R. Weitz, H. | Hosp Pract (1995) | 2023 |
Humans, Aged, Analgesics, Opioid/therapeutic use, Prospective Studies |
| Precision-based approaches to delirium in critical illness: A narrative review | Ankravs, M. J. McKenzie, C. A. Kenes, M. T. | Pharmacotherapy | 2023 |
Humans, Delirium/diagnosis/drug therapy/etiology, Intensive Care Units |
| Associations between early in-hospital medications and the development of delirium in patients with stroke | Ryan, S. L. Liu, X. McKenna, V. Ghanta, M. Muniz, C. Renwick, R. Westover, M. B. Kimchi, E. Y. | J Stroke Cerebrovasc Dis | 2023 |
Humans |
| Family-centered delirium prevention and treatment using video calls: the FACE Delirium trial | Trabert, J. Schenk, A. Golbach, R. Püllen, R. Schütze, S. | Eur Geriatr Med | 2023 |
Delirium |
| Early Onset Delirium During Hospitalization Increases In-Hospital and Postdischarge Mortality in COVID-19 Patients: A Multicenter Prospective Study | Trevisan, C. Grande, G. Rebora, P. Zucchelli, A. Valsecchi, M. G. Focà, E. Ecarnot, F. Marengoni, A. Bellelli, G. | J Clin Psychiatry | 2023 |
Humans |
| Accuracy of a clinical decision support system based on the 3-minute diagnostic interview for CAM-defined delirium: A validation study(✰) | Wang, J. Ji, M. Huang, Y. Yang, F. Wu, Y. | Geriatr Nurs | 2023 |
Humans |
| Psychological stress and associated factors in caring for patients with delirium among intensive care unit nurses: A cross-sectional study | Wang, Y. Li, L. Tan, S. Guan, Y. Luo, X. | Aust Crit Care | 2023 |
Humans |
| Inflammatory biomarkers and delirium: a Mendelian randomization study | Yu, M. Li, Y. Li, B. Ge, Q. | Front Aging Neurosci | 2023 |
Il-6
|
| Knowledge, attitude and practice regarding hypoactive delirium among ICU nurses: A nationwide cross-sectional study | Yu, M. Mi, J. Zhang, C. Chen, H. Luo, X. | Nurse Educ Pract | 2023 |
Attitude |
| Potentials of Acetylcholinesterase and Butyrylcholinesterase Alterations in On-Pump Coronary Artery Bypass Surgery in Postoperative Delirium: An Observational Trial | Zajonz, T. S. Kunzemann, C. Schreiner, A. L. Beckert, F. Schneck, E. Boening, A. Markmann, M. Sander, M. Koch, C. | J Clin Med | 2023 |
cardiac surgery |
| Peripheral cholinesterase activity is not correlated with postoperative delirium in urological surgery | Zangl, Q. Sprinz, B. von Dossow, V. | J Perioper Pract | 2023 |
Acetylcholinesterase |
| Biologic correlates associated with poor functional recovery after delirium: A nested prospective cohort study | Dasgupta, M. Brymer, C. | Health Sci Rep | 2023 |
activities of daily living |
| ICU Delirium Is Associated with Cardiovascular Burden and Higher Mortality in Patients with Severe COVID-19 Pneumonia | Gutowski, M. Klimkiewicz, J. Michałowski, A. Ordak, M. Możański, M. Lubas, A. | J Clin Med | 2023 |
Covid-19 |
| Analysis of risk factors for postoperative delirium in middle-aged and elderly fracture patients in the perioperative period | An, Z. Xiao, L. Chen, C. Wu, L. Wei, H. Zhang, X. Dong, L. | Sci Rep | 2023 |
Aged |
| Korkatti-Puoskari, N. Tiihonen, M. Caballero-Mora, M. A. Topinkova, E. Szczerbińska, K. Hartikainen, S. | Therapeutic dilemma's: antipsychotics use for neuropsychiatric symptoms of dementia, delirium and insomnia and risk of falling in older adults, a clinical review | Eur Geriatr Med | 2023 |
Humans |
| The efficacy and safety of haloperidol for the treatment of delirium in critically ill patients: a systematic review and meta-analysis of randomized controlled trials | Huang, J. Zheng, H. Zhu, X. Zhang, K. Ping, X. | Front Med (Lausanne) | 2023 |
Icu |
| A prospective randomized study examining the impact of intravenous versus inhalational anesthesia on postoperative cognitive decline and delirium | Farrer, T. J. Monk, T. G. McDonagh, D. L. Martin, G. Pieper, C. F. Koltai, D. | Appl Neuropsychol Adult | 2023 |
Anesthesia type |
| Factors Associated with Improvement in Activities of Daily Living during Hospitalization: A Retrospective Study of Older Patients with Hip Fractures | Takeda, K. Wada, M. Yorozuya, K. Hara, Y. Watanabe, T. Hanaoka, H. | Ann Geriatr Med Res | 2023 |
Activities of daily living |
| Associations Between Dysphagia and Adverse Health Outcomes in Older Adults with Dementia in Intensive Care Units: A Retrospective Cohort Study | Cheng, H. Deng, X. Li, J. Tang, Y. Yuan, S. Huang, X. Wang, Z. Zhou, F. Lyu, J. | Clin Interv Aging | 2023 |
Humans |
| Microvascular reconstruction for oral cancer in older adult patients: the impact of age on surgical outcomes | Kouketsu, A. Kaneuji, T. Yamaguma, Y. Yamauchi, K. Sugiura, T. Takahashi, T. Ito, H. Yamashita, Y. | Oral Surg Oral Med Oral Pathol Oral Radiol | 2023 |
oral, cancer, surgical, adults, elderly |
| Postoperative delirium is a risk factor of institutionalization after hip fracture: an observational cohort study | Labaste, F. Delort, F. Ferré, F. Bounes, F. Reina, N. Valet, P. Dray, C. Minville, V. | Front Med (Lausanne) | 2023 |
delirium |
| Prognostic significance of delirium in patients with heart failure: a systematic review and meta-analysis | Niu, Z. Zhou, J. Li, Y. | Front Cardiovasc Med | 2023 |
delirium |
| Postoperative delirium in 47 379 individuals undergoing transcatheter aortic valve replacement: a systematic review and meta-analysis | Ochani, S. Adnan, A. Siddiqui, A. Kalwar, A. Kukreja, S. Ahmad, M. Ashraf, M. H. Asghar, M. A. | Ann Med Surg (Lond) | 2023 |
Cam, Tavr, confusion assessment method, delirium, stroke, transcatheter aortic valve replacement |
| ICU Readmission in Injured Older Adults: Modifiable Risk Factors and Implications | Agoubi, L. L. Reimel, B. A. Maine, R. G. O'Connell, K. M. Maier, R. V. McIntyre, L. K. | J Trauma Acute Care Surg | 2023 |
ICU, delirium, older adults, risk factors, readmission |
| Motorist disorientation syndrome; clinical features and vestibular findings | Ainsworth, C. Davies, R. Colvin, I. Murdin, L. | J Vestib Res | 2023 |
Humans |
| External validity of an automated delirium prediction model (DEMO) and comparison to the manual VMS-questions: a retrospective cohort study | Ali, M. I. M. Kalkman, G. A. Wijers, C. H. W. Fleuren, Hwha Kramers, C. de Wit, Hajm | Int J Clin Pharm | 2023 |
Humans |
| Role of Intraoperative Neuromonitoring to Predict Postoperative Delirium in Cardiovascular Surgery | Al-Qudah, A. M. Ta'ani, O. A. Thirumala, P. D. Sultan, I. Visweswaran, S. Nadkarni, N. Kiselevskaya, V. Crammond, D. J. Balzer, J. Anetakis, K. M. Shandal, V. Subramanium, K. Subramanium, B. Sadhasivam, S. | J Cardiothorac Vasc Anesth | 2023 |
Eeg, Ionm, Ssep, cardiac, delirium, postoperative |
| Comparison of the hemodynamic effects of opioid-based versus lidocaine-based induction of anesthesia with propofol in older adults: a randomized controlled trial | Amin, S. M. Hasanin, A. ElSayed, O. S. Mostafa, M. Khaled, D. Arafa, A. S. Hassan, A. | Anaesth Crit Care Pain Med | 2023 |
Humans |
| Effect of pharmacist-led intervention protocol on preventing postoperative delirium after elective cardiovascular surgery | Asai, Y. Yanagawa, T. Takahashi, M. | PLoS One | 2023 |
Adult, Humans, *Emergence Delirium, Pharmacists, Retrospective Studies, Benzodiazepines/adverse effects |
| Taming Postoperative Delirium with Dexmedetomidine: A Review of the Therapeutic Agent's Neuroprotective Effects following Surgery | Bargnes, V., 3rd Oliver, B. Wang, E. Greenspan, S. Jin, Z. Yeung, I. Bergese, S. | Pharmaceuticals (Basel) | 2023 |
dexmedetomidine |
| Level of implementation of pain management and early mobilization strategies to prevent delirium in geriatric trauma patients: A mixed-methods study | Beaudoin, M. Belzile, E. L. Gélinas, C. Trépanier, D. Émond, M. Gagnon, M. A. Bérubé, M. | Int J Orthop Trauma Nurs | 2023 |
Delirium, Early mobilization, Geriatric trauma, Mixed-methods, Pain management, Practice guidelines |
| Dose-dependent QTc interval prolongation under haloperidol and pipamperone in the management of delirium in a naturalistic setting | Bohny, P. Boettger, S. Jenewein, J. | Front Psychiatry | 2023 |
QTc interval, delirium, haloperidol, pipamperone, torsades de pointes |
| Prevalence and risk factors of subsyndromal delirium among postoperative patients: A systematic review and meta-analysis | Chen, S. Tang, L. Chen, J. Cai, L. Liu, C. Song, J. Chen, Y. Liu, Y. Zheng, S. | J Adv Nurs | 2023 |
Subsyndromal delirium, meta-analysis, nurse, nursing, postoperative care, prevalence, risk factors, surgery |
| Incidence change of postoperative delirium after implementation of processed electroencephalography monitoring during surgery: a retrospective evaluation study | Chen, Y. C. Hung, I. Y. Hung, K. C. Chang, Y. J. Chu, C. C. Chen, J. Y. Ho, C. H. Yu, C. H. | BMC Anesthesiol | 2023 |
Humans |
| Incidence and risk factors for postoperative delirium after head and neck cancer surgery: an updated meta-analysis | Dong, B. Yu, D. Jiang, L. Liu, M. Li, J. | BMC Neurol | 2023 |
Humans |
| Five-year stroke prognosis. Influence of post-stroke delirium and post-stroke dementia on mortality and disability (Research Study - Part of the PROPOLIS Study) | Droś, J. Segiet, N. Początek, G. Klimkowicz-Mrowiec, A. | Neurol Sci | 2023 |
Cognition disorders, Delirium, Dementia, Mortality, Stroke |
| Comparison of continuous sedatives in the burn ICU on delirium and coma | Falksen, J. Young, S. R. Lee, J. A. | J Burn Care Res | 2023 |
burn, coma, delirium, sedation |
| Associations between depression symptom burden and delirium risk: a prospective cohort study | Gaba, A. Li, P. Xi, Z. Gao, C. Ruixue, C. Hu, K. Gao, L. | medRxiv | 2023 |
Altered mental status |
| Delirium and Previous Psychiatric History Independently Predict Poststroke Posttraumatic Stress Disorder | Griffin, T. T. Bhave, V. McNulty, J. Christophe, B. R. Garton, A. L. A. Sander Connolly, E., Jr. | Neurologist | 2023 |
Humans, Female, *Stress Disorders, Post Traumatic/epidemiology/etiology/diagnosis, *Stroke/complications/epidemiology, *Delirium/diagnosis/epidemiology/etiology |
| Incidence of Postoperative Delirium in Cancer Patients After Head and Neck Surgery: A Proportional Meta-analysis | Ho, M. H. Li, P. W. C. Lin, Y. K. Lee, J. J. Lin, C. C. | Otolaryngol Head Neck Surg | 2023 |
cancer, delirium, head and neck cancer, incidence, postoperative, proportional Meta-analysis |
| Triglyceride-glucose index as a valuable predictor for aged 65-years and above in critical delirium patients: evidence from a multi-center study | Huang, X. Cheng, H. Yuan, S. Ling, Y. Tan, S. Tang, Y. Niu, C. Lyu, J. | BMC Geriatr | 2023 |
Humans |
| Reliability and Validity of the Spanish Adaptation of the Stanford Proxy Test for Delirium in 2 Clinical Spanish-Speaking Communities | Infante, S. Behn, A. González, M. Pintor, L. Franco, E. Araya, P. Maldonado, J. R. | J Acad Consult Liaison Psychiatry | 2023 |
Stanford proxy test for delirium, confusion assessment method, delirium, delirium and COVID, factor analysis |
| Association between preoperative neutrophil-lymphocyte ratio, uric acid, and postoperative delirium in elderly patients undergoing degenerative spine surgery | Kato, K. Kinoshita, H. Kumagai, G. Takekawa, D. Nitobe, Y. Asari, T. Wada, K. Kushikata, T. Ishibashi, Y. Hirota, K. | J Anesth | 2023 |
Neuroprotection, Neutrophil–lymphocyte ratio, Postoperative delirium, Spine surgery, Uric acid |
| Preoperative assessment of postoperative delirium: a cross-sectional study of patients and anesthesiologists in Canada | Khaled, M. Youssef, N. Choi, S. Uppal, V. Chui, J. Marcucci, M. Madden, K. Shanthanna, H. | Can J Anaesth | 2023 |
Humans |
| Resting-state prefrontal EEG biomarker in correlation with postoperative delirium in elderly patients | Kim, J. Park, S. Kim, K. N. Ha, Y. Shin, S. J. Cha, W. Lee, K. Y. Choi, J. Koo, B. N. | Front Aging Neurosci | 2023 |
elderly, electroencephalography, median dominant frequency, postoperative complications, postoperative delirium |
| Risk of delirium with antiepileptic drug use: a study based on the Japanese Adverse Drug Event Report database | Kubo, T. Sogawa, R. Tsuruhashi, S. Murakawa-Hirachi, T. Matsuoka, A. Mizoguchi, Y. Monji, A. Shimanoe, C. | Int J Clin Pharm | 2023 |
Humans |