What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Development and Validation of an Electronic Health Record-Based Machine Learning Model to Estimate Delirium Risk in Newly Hospitalized Patients Without Known Cognitive Impairment. | Wong, A. Young, A. T. Liang, A. S. Gonzales, R. Douglas, V. C. Hadley, D. | JAMA Netw Open | 2018 | |
| Sedative drugs used for mechanically ventilated patients in intensive care units: a systematic review and network meta-analysis. | Wang, H. Wang, C. Wang, Y. Tong, H. Feng, Y. Li, M. Jia, L. Yu, K. | Curr Med Res Opin | 2018 |
Sedative drugs |
| Prediction of length of hospital stay and mortality in patients with delirium: A prospective cohort analysis of 200 ICU patients. | Tian, J. Chen, X. Liu, D. | Journal of Biological Regulators and Homeostatic Agents | 2018 |
adult |
| Ramelteon is Not Associated With Improved Outcomes Among Critically Ill Delirious Patients: A Single-Center Retrospective Cohort Study. | Thom, R. Bui, M. Rosner, B. Teslyar, P. Levy-Carrick, N. Wolfe, D. Klompas, M. | Psychosomatics | 2018 |
Delirium |
| A daily multidisciplinary assessment of older adults undergoing elective colorectal cancer surgery is associated with reduced delirium and geriatric syndromes. | Tarazona-Santabalbina, F. J. Llabata-Broseta, J. Belenguer-Varea, A. Alvarez-Martinez, D. Cuesta-Peredo, D. Avellana-Zaragoza, J. A. | J Geriatr Oncol | 2018 |
Colorectal surgery |
| Preventive Effect of Suvorexant for Postoperative Delirium after Coronary Artery Bypass Grafting. | Tamura, K. Maruyama, T. Sakurai, S. | Ann Thorac Cardiovasc Surg | 2018 |
Suvorexant |
| Aproach to the risk of delirium in an orthogeriatric unit. | Sopena Bert, E. Qanneta, R. Valenti Moreno, V. San Jose Laporte, A. | Med Clin | 2018 |
Delirium |
| A systematic review of the use of music interventions to improve outcomes for patients undergoing hip or knee surgery. | Sibanda, A. Carnes, D. Visentin, D. Cleary, M. | J Adv Nurs | 2018 |
anxiety |
| Use of "Months of the Year Backwards" (MOTYB) as a Screening Tool for Delirium in Palliative Care Patients in the Acute Hospital Setting. | Ryan, S. Hayes, D. Creedon, B. | Ir Med J | 2018 | |
| Impact of psychotic symptoms on clinical outcomes in delirium. | Paik, S. H. Ahn, J. S. Min, S. Park, K. C. Kim, M. H. | PLoS ONE | 2018 |
neuroleptic agent |
| Preoperative age and prognostic nutritional index are useful factors for evaluating postoperative delirium among patients with adult spinal deformity. | Oe, S. Togawa, D. Yamato, Y. Hasegawa, T. Yoshida, G. Kobayashi, S. Yasuda, T. Banno, T. Arima, H. Mihara, Y. Ushirozako, H. Yamada, T. Matsuyama, Y. | Spine | 2018 | |
| Decreased Risk of Delirium With Use of Regional Analgesia in Geriatric Trauma Patients With Multiple Rib Fractures. | O'Connell, K. M. Quistberg, D. A. Tessler, R. Robinson, B. R. H. Cuschieri, J. Maier, R. V. Rivara, F. P. Vavilala, M. S. Bhalla, P. I. Arbabi, S. | Ann Surg | 2018 |
OBJECTIVE: The aim of this study was to examine the risk of delirium in geriatric trauma patients with rib fractures treated with systemic opioids compared with those treated with regional analgesia (RA). SUMMARY OF BACKGROUND DATA: Delirium is a modifiable complication associated with increased morbidity and mortality. RA may reduce the need for opioid medications, which are associated with delirium in older adults. METHODS: Cohort study of patients >/=65 years admitted to a regional trauma center from 2011 to 2016. Inclusion factors were >/= 3 rib fractures, blunt trauma mechanism, and admission to intensive care unit (ICU). Exclusion criteria included head AIS >/=3, spine AIS >/=3, dementia, and death within 24 hours. The primary outcome was delirium positive ICU days, defined using the CAM-ICU assessment. Delirium incident rate ratios (IRRs) and 95% confidence intervals (95% CIs) were estimated using generalized linear mixed models with Poisson distribution and robust standard errors. RESULTS: Of the 144 patients included in the study, 27 (19%) received Acute Pain Service consultation and RA and 117 (81%) received opioid-based systemic analgesia. Patients with RA had more severe chest injury than those without. The risk of delirium decreased by 24% per day per patient with use of RA (IRR 0.76, 95% CI 0.61 to 0.96). Individual opioid use, as measured in daily morphine equivalents (MEDs), was significantly reduced after initiation of RA (mean difference -7.62, 95% CI -14.4 to -0.81). CONCLUSION: Although use of RA techniques in geriatric trauma patients with multiple rib fractures was associated with higher MED, opioid use decreased after RA initiation and Acute Pain Service consultation, and the risk of delirium was lower. |
| Hypotension and a positive fluid balance are associated with delirium in patients with shock. | Nguyen, D. N. Huyghens, L. Parra, J. Schiettecatte, J. Smitz, J. Vincent, J. L. | PLoS One | 2018 | |
| End-Tidal Hypocapnia Under Anesthesia Predicts Postoperative Delirium. | Mutch, W. A. C. El-Gabalawy, R. Girling, L. Kilborn, K. Jacobsohn, E. | Front Neurol | 2018 |
*anesthetic agent |
| Risk Factors for Delirium after Spine Surgery: An Age-Matched Analysis. | Morino, T. Hino, M. Yamaoka, S. Misaki, H. Ogata, T. Imai, H. Miura, H. | Asian Spine J | 2018 |
Delirium |
| Outcomes of Patients With Delirium in Long-Term Care Facilities: A Prospective Cohort Study. | Moon, K. J. Park, H. | J Gerontol Nurs | 2018 |
Aged |
| Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery. | Miller, D. Lewis, S. R. Pritchard, M. W. Schofield-Robinson, O. J. Shelton, C. L. Alderson, P. Smith, A. F. | Cochrane Database of Systematic Reviews | 2018 |
Aged |
| Incidence, risk factors and clinical impact of postoperative delirium following open reduction and internal fixation (ORIF) for hip fractures: an analysis of 7859 patients from the ACS-NSQIP hip fracture procedure targeted database. | Malik, A. T. Quatman, C. E. Phieffer, L. S. Ly, T. V. Khan, S. N. | Eur J Orthop Surg Traumatol | 2018 |
Delirium |
| Delirium After Cardiac Surgery and Cumulative Fluid Balance: A Case-Control Cohort Study. | Mailhot, T. Cossette, S. Lambert, J. Beaubien-Souligny, W. Cournoyer, A. O'Meara, E. Maheu-Cadotte, M. A. Fontaine, G. Bouchard, J. Lamarche, Y. Benkreira, A. Rochon, A. Denault, A. | J Cardiothorac Vasc Anesth | 2019 |
cardiac surgery |
| The point-of-care EEG for delirium detection in the emergency department. | Lee, S. Yuki, K. Chan, A. Cromwell, J. Shinozaki, G. | Am J Emerg Med | 2018 |
Bispectral EEG |
| Intraoperative hypotension is not associated with postoperative cognitive dysfunction in elderly patients undergoing general anesthesia for surgery: results of a randomized controlled pilot trial. | Langer, T. Santini, A. Zadek, F. Chiodi, M. Pugni, P. Cordolcini, V. Bonanomi, B. Rosini, F. Marcucci, M. Valenza, F. Marenghi, C. Inglese, S. Pesenti, A. Gattinoni, L. | J Clin Anesth | 2019 |
Anesthesia, general |
| Differences in healthcare outcomes between teaching and non teaching hospitals for patients with delirium: a retrospective cohort study. | Kotwal, S. Abougergi, M. S. Wright, S. | Int J Qual Health Care | 2018 | |
| Gender differences in the use of atypical antipsychotic medications for ICU delirium. | Karamchandani, K. Schoaps, R. S. Printz, J. Kowaleski, J. M. Carr, Z. J. | Crit Care | 2018 | |
| Whole-Genome mRNA Gene Expression Differs Between Patients With and Without Delirium. | Kalantar, K. LaHue, S. C. DeRisi, J. L. Sample, H. A. Contag, C. A. Josephson, S. A. Wilson, M. R. Douglas, V. C. | Journal of Geriatric Psychiatry and Neurology | 2018 |
integrin |
| Incidence and risk factors of subsyndromal delirium after curative resection of gastric cancer. | Hwang, H. Lee, K. M. Son, K. L. Jung, D. Kim, W. H. Lee, J. Y. Kong, S. H. Suh, Y. S. Lee, H. J. Yang, H. K. Hahm, B. J. | BMC Cancer | 2018 |
adult |
| Performance of Electronic Prediction Rules for Prevalent Delirium at Hospital Admission. | Halladay, C. W. Sillner, A. Y. Rudolph, J. L. | JAMA Netw Open | 2018 | |
| Harmonization of delirium severity instruments: a comparison of the DRS-R-98, MDAS, and CAM-S using item response theory. | Gross, A. L. Tommet, D. D'Aquila, M. Schmitt, E. Marcantonio, E. R. Helfand, B. Inouye, S. K. Jones, R. N. | BMC Med Res Methodol | 2018 |
Delirium |
| Prognostic factors of inhospital death in elderly patients: A time-to-event analysis of a cohort study in Martinique (French West Indies). | Godaert, L. Bartholet, S. Dorléans, F. Najioullah, F. Colas, S. Fanon, J. L. Cabié, A. Césaire, R. Dramé, M. | BMJ Open | 2018 |
aged |
| The Critical Vital Sign of Cognitive Health and Delirium: Whose Responsibility Is It? | Fick, D. M. | J Gerontol Nurs | 2018 | |
| Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. | Devlin, J. W. Skrobik, Y. Gelinas, C. Needham, D. M. Slooter, A. J. C. Pandharipande, P. P. Watson, P. L. Weinhouse, G. L. Nunnally, M. E. Rochwerg, B. Balas, M. C. van den Boogaard, M. Bosma, K. J. Brummel, N. E. Chanques, G. Denehy, L. Drouot, X. Fraser | Crit Care Med | 2018 | |
| Delirium etiology subtypes and their effect on six-month function and cognition in older emergency department patients. | Cirbus, J. MacLullich, A. M. J. Noel, C. Ely, E. W. Chandrasekhar, R. Han, J. H. | International Psychogeriatrics | 2018 |
aged |
| Perioperative Sedation in Mechanically Ventilated Cardiac Surgery Patients With Dexmedetomidine-Based Versus Propofol-Based Regimens. | Chuich, T. Cropsey, C. L. Shi, Y. Johnson, D. Shotwell, M. S. Henson, C. P. | Ann Pharmacother | 2019 |
anesthesia |
| Hospital discharge data under-reports delirium occurrence. Results from a point prevalence survey of delirium in a major Australian health service. | Casey, P. Cross, W. Webb-St Mart, M. Baldwin, C. Riddell, K. Darzins, P. | Intern Med J | 2018 |
Adult |
| TIME to think about delirium: improving detection and management on the acute medical unit. | Bauernfreund, Y. Butler, M. Ragavan, S. Sampson, E. L. | BMJ Open Qual | 2018 |
Pdsa |
| The Association of Delirium with Perioperative Complications in Primary Elective Total Hip Arthroplasty. | Aziz, K. T. Best, M. J. Naseer, Z. Skolasky, R. L. Ponnusamy, K. E. Sterling, R. S. Khanuja, H. S. | Clin Orthop Surg | 2018 |
Aged |
| Bispectral Index Monitoring During Anesthesia Promotes Early Postoperative Recovery of Cognitive Function and Reduces Acute Delirium in Elderly Patients with Colon Carcinoma: A Prospective Controlled Study using the Attention Network Test. | Zhou, Y. Li, Y. Wang, K. | Med Sci Monit | 2018 |
Aged |
| Military Service Members and Emergence Delirium Screening: An Evidence-Based Practice Project. | Wheat, L. L., 2nd Turner, B. S. Diaz, A. Maani, C. V. | J Perianesth Nurs | 2018 |
emergence delirium |
| Can delirium research activity impact on routine delirium recognition? A prospective cohort study. | Welch, C. Jackson, T. A. | BMJ Open | 2018 |
dementia |
| Preoperative STOP-BANG Scores and Postoperative Delirium and Coma in Thoracic Surgery Patients. | Wang, S. Sigua, N. L. Manchanda, S. Gradney, S. Khan, S. H. Perkins, A. Kesler, K. Khan, B. | Ann Thorac Surg | 2018 | |
| The Cost of ICU Delirium and Coma in the Intensive Care Unit Patient. | Vasilevskis, E. E. Chandrasekhar, R. Holtze, C. H. Graves, J. Speroff, T. Girard, T. D. Patel, M. B. Hughes, C. G. Cao, A. Pandharipande, P. P. Ely, E. W. | Med Care | 2018 | |
| Pharmacologic prevention of postoperative delirium after on-pump cardiac surgery: A meta-analysis of randomized trials. | Tao, R. Wang, X. W. Pang, L. J. Cheng, J. Wang, Y. M. Gao, G. Q. Liu, Y. Wang, C. | Medicine | 2018 |
Antipsychotic Agents/*therapeutic use |
| Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging. | Shinozaki, G. Braun, P. R. Hing, B. W. Q. Ratanatharathorn, A. Klisares, M. J. Duncan, G. N. Jellison, S. S. Heinzman, J. T. Nagahama, Y. Close, L. Sabbagh, S. Dlouhy, B. J. Howard, M. A. Kawasaki, H. Cho, H. R. | Front Aging Neurosci | 2018 |
DNA methylation |
| The Hospital Elder Life Program: Past and Future. | Scheunemann, L. P. Girard, T. D. Skidmore, E. R. Resnick, N. M. | Am J Geriatr Psychiatry | 2018 | |
| Delirium in the Acute Phase of Ischemic Stroke: Incidence, Risk Factors, and Effects on Functional Outcome. | Qu, J. Chen, Y. Luo, G. Zhong, H. Xiao, W. Yin, H. | J Stroke Cerebrovasc Dis | 2018 |
Activities of Daily Living |
| Effect of dynamic light at the coronary care unit on the length of hospital stay and development of delirium: A retrospective cohort study. | Pustjens, T. Schoutens, A. M. C. Janssen, L. Heesen, W. F. | Journal of Geriatric Cardiology | 2018 |
neuroleptic agent |
| Frailty and Delirium in Older Adults: A Systematic Review and Meta-Analysis of the Literature. | Persico, I. Cesari, M. Morandi, A. Haas, J. Mazzola, P. Zambon, A. Annoni, G. Bellelli, G. | J Am Geriatr Soc | 2018 |
cognition |
| Medications and Patient Characteristics Associated With Falling in the Hospital. | OʼNeil, C. A. Krauss, M. J. Bettale, J. Kessels, A. Costantinou, E. Dunagan, W. C. Fraser, V. J. | Journal of Patient Safety | 2018 |
adult |
| Delirium detection using relative delta power based on 1-minute single-channel EEG: a multicentre study. | Numan, T. van den Boogaard, M. Kamper, A. M. Rood, P. J. T. Peelen, L. M. Slooter, A. J. C. | Br J Anaesth | 2018 |
complications, postoperative |
| Low skeletal muscle mass as a risk factor for postoperative delirium in elderly patients undergoing colorectal cancer surgery. | Mosk, C. A. L. A. van Vugt J de Jonge, H. Witjes, C. D. Buettner, S. Ijzermans, J. N. van der Laan, L. | Clin Interv Aging | 2018 |
Aged |
| Symptom expression in advanced cancer patients admitted to hospice or home care with and without delirium. | Mercadante, S. Masedu, F. Maltoni, M. De Giovanni, D. Montanari, L. Pittureri, C. Berte, R. Russo, D. Ursini, L. Marinangeli, F. Aielli, F. | Intern Emerg Med | 2018 |
Advanced cancer |
| Symptom Expression in Patients with Advanced Cancer Admitted to an Acute Supportive/Palliative Care Unit With and Without Delirium. | Mercadante, S. Adile, C. Ferrera, P. Cortegiani, A. Casuccio, A. | Oncologist | 2018 |
Advanced cancer |
| Pain, agitation and delirium assessment and management in a community medical-surgical ICU: results from a prospective observational study and nurse survey. | Maximous, R. Miller, F. Tan, C. Camargo, M. Ross, K. Marshall, C. Yung, P. Fleming, D. Law, M. Tsang, J. L. Y. | BMJ Open Qual | 2018 |
attitudes |
| Evaluating the risk profile of quetiapine in treating delirium in the intensive care adult population: A retrospective review. | Mangan, K. C. McKinzie, B. P. Deloney, L. P. Leon, S. M. Eriksson, E. A. | J Crit Care | 2018 |
Delirium |
| Cerebral monitoring of anaesthesia on reducing cognitive dysfunction and postoperative delirium: a systematic review. | Luo, C. Zou, W. | J Int Med Res | 2018 |
Anesthesia/*adverse effects/methods |
| Dysfunctional cerebral autoregulation is associated with delirium in critically ill adults. | Lee, K. F. Wood, M. D. Maslove, D. M. Muscedere, J. G. Boyd, J. G. | J Cereb Blood Flow Metab | 2018 |
Cerebral autoregulation |
| Defining delirium in idiopathic Parkinson's disease: A systematic review. | Lawson, R. A. McDonald, C. Burn, D. J. | Parkinsonism and Related Disorders | 2018 |
adult |
| Delirium assessment in neuro-critically ill patients: A validation study. | Larsen, L. K. Frokjaer, V. G. Nielsen, J. S. Skrobik, Y. Winkler, Y. Moller, K. Petersen, M. Egerod, I. | Acta Anaesthesiol Scand | 2018 |
acute brain injury |
| Benzodiazepine Use and Neuropsychiatric Outcomes in the ICU: A Systematic Review | Kok, L. Slooter, A. J. Hillegers, M. H. van Dijk, D. Veldhuijzen, D. S. | Crit Care Med | 2018 | |
| Hospital Elder Life Program: Systematic Review and Meta-analysis of Effectiveness | Hshieh, T. T. Yang, T. Gartaganis, S. L. Yue, J. Inouye, S. K. | Am J Geriatr Psychiatry | 2018 |
Delirium prevention |
| Predictive Modeling for Geriatric Hip Fracture Patients: Early Surgery and Delirium Have the Largest Influence on Length of Stay. | Hecht, G. Slee, C. A. Goodell, P. B. Taylor, S. L. Wolinsky, P. R. | J Am Acad Orthop Surg | 2018 | |
| The Erasmus Frailty Score is associated with delirium and 1-year mortality after Transcatheter Aortic Valve Implantation in older patients. The TAVI Care & Cure program. | Goudzwaard, J. A. de Ronde-Tillmans, Mjag El Faquir, N. Acar, F. Van Mieghem, N. M. Lenzen, M. J. de Jaegere, P. P. T. Mattace-Raso, F. U. S. | Int J Cardiol | 2019 |
Delirium |
| Transcutaneous electrical acupoint stimulation for prevention of postoperative delirium in geriatric patients with silent lacunar infarction: a preliminary study. | Gao, F. Zhang, Q. Li, Y. Tai, Y. Xin, X. Wang, X. Wang, Q. | Clin Interv Aging | 2018 |
*Acupuncture Points |
| Dexmedetomidine in prevention and treatment of postoperative and intensive care unit delirium: a systematic review and meta-analysis. | Flükiger, J. Hollinger, A. Speich, B. Meier, V. Tontsch, J. Zehnder, T. Siegemund, M. | Annals of Intensive Care | 2018 |
dexmedetomidine |
| Long-term prognostic value of delirium in elderly patients with acute cardiac diseases admitted to two cardiac intensive care units: a prospective study (DELIRIUM CORDIS). | Falsini, G. Grotti, S. Porto, I. Toccafondi, G. Fraticelli, A. Angioli, P. Ducci, K. Liistro, F. Pieroni, M. Taddei, T. Romanelli, S. Rossi, R. Bolognese, L. | Eur Heart J Acute Cardiovasc Care | 2018 |
Acute Disease |
| Persistent Delirium in Elderly patients Three Months After Hospital Discharge from a University Clinic. | Constaín, G. A. Ocampo Saldarriaga, M. V. Velásquez Tirado, J. D. Rodríguez-Gázquez, M. D. L. Á Betancur Morales, L. M. Rico Escobar, J. J. Castilla Agudelo, G. A. Maya Osorno, A. F. | Revista Colombiana de Psiquiatria | 2018 |
aged |
| A Web-Based Serious Game on Delirium as an Educational Intervention for Medical Students: Randomized Controlled Trial. | Buijs-Spanjers, K. R. Hegge, H. H. Jansen, C. J. Hoogendoorn, E. de Rooij, S. E. | JMIR Serious Games | 2018 |
delirium |
| Relationship Between Near-Infrared Spectroscopy-Derived Cerebral Oxygenation and Delirium in Critically Ill Patients: A Systematic Review. | Bendahan, N. Neal, O. Ross-White, A. Muscedere, J. Boyd, J. G. | J Intensive Care Med | 2018 |
Cam-icu |
| Ability of suvorexant to prevent delirium in patients in the intensive care unit: a randomized controlled trial. | Azuma, K. Takaesu, Y. Soeda, H. Iguchi, A. Uchida, K. Ohta, S. Mishima, S. Inoue, T. Inoue, Y. Oda, J. | Acute Med Surg | 2018 |
Delirium |
| Incidence of postoperative delirium in elderly ambulatory patients: A prospective evaluation using the FAM-CAM instrument. | Aya, A. G. M. Pouchain, P. H. Thomas, H. Ripart, J. Cuvillon, P. | J Clin Anesth | 2018 |
Ambulatory surgery |
| Potential Role of Exogenous Melatonin Supplement in Delirium Prevention in Critically Ill Patients: A Double-Blind Randomized Pilot Study. | Abbasi, S. Farsaei, S. Ghasemi, D. Mansourian, M. | Iran J Pharm Res | 2018 |
Clinical trial |
| Predictive nomogram for postoperative delirium in elderly patients with a hip fracture. | Zhang, X. Tong, D. K. Ji, F. Duan, X. Z. Liu, P. Z. Qin, S. Xu, K. H. Di-li, X. T. | Injury | 2018 |
aged |
| Advances in dementia with Lewy bodies | Armstrong, M. J. | Ther Adv Neurol Disord | 2021 |
Lewy body dementia |
| Factors Influencing CAM-ICU Documentation and Inappropriate "Unable to Assess" Responses | Awan, O. M. Buhr, R. G. Kamdar, B. B. | Am J Crit Care | 2021 |
Aged, 80 and over |
| Prediction of Postictal Delirium Following Status Epilepticus in the ICU: First Insights of an Observational Cohort Study | Baumann, S. M. Semmlack, S. Hunziker, S. Kaplan, P. W. De Marchis, G. M. Rüegg, S. Marsch, S. Sutter, R. | Crit Care Med | 2021 |
Aged |
| Dementia as a predictor of morbidity and mortality in patients with delirium. | van Roessel, S. Keijsers, C. J. P. W. Romijn, M. D. M. | Maturitas | 2019 |
advance care planning |
| Factors Associated With Delirium Following Electroconvulsive Therapy: A Systematic Review. | Tsujii, T. Uchida, T. Suzuki, T. Mimura, M. Hirano, J. Uchida, H. | J Ect | 2019 | |
| Predictors of delirium after cardiac surgery in patients with sleep-disordered breathing. | Tafelmeier, M. Knapp, M. Lebek, S. Floerchinger, B. Camboni, D. Creutzenberg, M. Wittmann, S. Zeman, F. Schmid, C. Maier, L. S. Wagner, S. Arzt, M. | Eur Respir J | 2019 | |
| The trajectory of C-reactive protein serum levels in older hip fracture patients with postoperative delirium. | Slor, C. J. Witlox, J. Adamis, D. Jansen, Rwmm Houdijk, A. P. J. van Gool, W. A. de Jonghe, J. F. M. Eikelenboom, P. | Int J Geriatr Psychiatry | 2019 |
C-reactive protein |
| Risk Factors for Postoperative Delirium in Type A Aortic Dissection Patients: A Retrospective Study. | Shi, Q. Mu, X. Zhang, C. Wang, S. Hong, L. Chen, X. | Med Sci Monit | 2019 | |
| Cortical and subcortical changes in resting-state functional connectivity before and during an episode of postoperative delirium. | Oh, J. Shin, J. E. Yang, K. H. Kyeong, S. Lee, W. S. Chung, T. S. Kim, J. J. | Aust N Z J Pschiatry | 2019 |
Postoperative delirium |
| Association of COMT Val(158)Met Polymorphism With Delirium Risk and Outcomes After Traumatic Brain Injury. | Nekrosius, D. Kaminskaite, M. Jokubka, R. Pranckeviciene, A. Lideikis, K. Tamasauskas, A. Bunevicius, A. | J Neuropsychiatry Clin Neurosci | 2019 |
Delirium |
| Association of earlier extubation and postoperative delirium after coronary artery bypass grafting. | Muller Moran, H. R. Maguire, D. Maguire, D. Kowalski, S. Jacobsohn, E. Mackenzie, S. Grocott, H. Arora, R. C. | Journal of Thoracic and Cardiovascular Surgery | 2019 |
adult |
| Delirium, Dementia, and In-Hospital Mortality: The Results From the Italian Delirium Day 2016, A National Multicenter Study. | Morandi, A. Di Santo, S. G. Zambon, A. Mazzone, A. Cherubini, A. Mossello, E. Bo, M. Marengoni, A. Bianchetti, A. Cappa, S. Fimognari, F. Antonelli Incalzi, R. Gareri, P. Perticone, F. Campanini, M. Penco, I. Montorsi, M. Di Bari, M. Trabucchi, M. Bellell | J Gerontol A Biol Sci Med Sci | 2019 |
Acute hospital |
| Type D personality is a predictor of prolonged acute brain dysfunction (delirium/coma) after cardiovascular surgery. | Matsuishi, Y. Shimojo, N. Unoki, T. Sakuramoto, H. Tokunaga, C. Yoshino, Y. Hoshino, H. Ouchi, A. Kawano, S. Sakamoto, H. Hiramatsu, Y. Inoue, Y. | BMC Psychol | 2019 |
Aged |
| Delirium after primary percutaneous coronary intervention in aged individuals with acute ST-segment elevation myocardial infarction: A retrospective study. | Li, S. Zhang, X. H. Zhou, G. D. Wang, J. F. | Exp Ther Med | 2019 |
ST-segment elevation |
| Preventing Delirium Takes a Village: Systematic Review and Meta-Analysis of Delirium Preventive Models of Care. | Khan, A. Boukrina, O. Oh-Park, M. Flanagan, N. A. Singh, M. Oldham, M. | J Hosp Med | 2019 | |
| Clinical predictors of postoperative delirium, functional status, and mortality in geriatric patients undergoing non-elective surgery for hip fracture. | Harris, M. J. Brovman, E. Y. Urman, R. D. | J Clin Anesth | 2019 |
Delirium |
| Impairments in balance and mobility identify delirium in patients with comorbid dementia. | Gual, N. Richardson, S. J. Davis, D. H. J. Bellelli, G. Hasemann, W. Meagher, D. Kreisel, S. H. MacLullich, A. M. J. Cerejeira, J. Inzitari, M. Morandi, A. | Int Psychogeriatr | 2019 |
Delirium |
| Delirium motor subtypes and prognosis in hospitalized geriatric patients - A prospective observational study. | Evensen, S. Saltvedt, I. Lydersen, S. Wyller, T. B. Taraldsen, K. Sletvold, O. | J Psychosom Res | 2019 |
Dmss |
| Delirium risk in non-surgical patients: systematic review of predictive tools. | Dylan, F. Byrne, G. Mudge, A. M. | Arch Gerontol Geriatr | 2019 |
clinical prediction rule |
| Pain, Opioid Intake, and Delirium Symptoms in Adults Following Joint Replacement Surgery. | Denny, D. L. Lindseth, G. N. | West J Nurs Res | 2019 |
joint replacement surgery |
| Addition of Vitamin B Complex to Prime Solution in Cobalamin-Deficient Patients to Prevent Postoperative Delirium. | Demirdas, E. Atilgan, K. | The Heart Surgery Forum | 2019 |
vitamin B complex |
| Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence | Daiello, L. A. Racine, A. M. Yun Gou, R. Marcantonio, E. R. Xie, Z. Kunze, L. J. Vlassakov, K. V. Inouye, S. K. Jones, R. N. Alsop, D. Travison, T. Arnold, S. Cooper, Z. Dickerson, B. Fong, T. Metzger, E. Pascual-Leone, A. Schmitt, E. M. Shafi, M. Cavalla | Anesthesiology | 2019 | |
| CSF Beta-amyloid 1-42 Concentration Predicts Delirium Following Elective Arthroplasty Surgery in an Observational Cohort Study. | Cunningham, E. L. McGuinness, B. McAuley, D. F. Toombs, J. Mawhinney, T. O'Brien, S. Beverland, D. Schott, J. M. Lunn, M. P. Zetterberg, H. Passmore, A. P. | Ann Surg | 2018 |
adverse outcome |
| Three Nurse-administered Protocols Reduce Nutritional Decline and Frailty in Older Gastrointestinal Surgery Patients: A Cluster Randomized Trial. | Chia-Hui Chen, C. Yang, Y. T. Lai, I. R. Lin, B. R. Yang, C. Y. Huang, J. Tien, Y. W. Chen, C. N. Lin, M. T. Liang, J. T. Li, H. C. Huang, G. H. Inouye, S. K. | J Am Med Dir Assoc | 2019 |
Frailty |
| Moderate hypercapnia may not contribute to postoperative delirium in patients undergoing bronchoscopic intervention. | Cheng, Q. Li, L. Yang, M. Sun, L. Li, R. Huang, R. Ma, J. | Medicine | 2019 |
Age Factors |
| Evaluation of a method to estimate the point prevalence of cognitive impairment and delirium in a multi-campus Australian health service. | Casey, P. Darzins, P. Webb-St Mart, M. Baldwin, C. Riddell, K. Johnson, C. Cross, W. | Australas J Ageing | 2019 |
adult |
| Effect of Targeting Mean Arterial Pressure During Cardiopulmonary Bypass by Monitoring Cerebral Autoregulation on Postsurgical Delirium Among Older Patients: A Nested Randomized Clinical Trial. | Brown, C. H. th Neufeld, K. J. Tian, J. Probert, J. LaFlam, A. Max, L. Hori, D. Nomura, Y. Mandal, K. Brady, K. Hogue, C. W. Shah, A. Zehr, K. Cameron, D. Conte, J. Bienvenu, O. J. Gottesman, R. Yamaguchi, A. Kraut, M. | JAMA Surg | 2019 | |
| A Comparison of Resource Utilization in the Management of Anticholinergic Delirium Between Physostigmine and Nonantidote Therapy. | Boley, S. P. Stellpflug, S. J. | Annals of Pharmacotherapy | 2019 |
adult |
| Do health care professionals worry about delirium? Relatives' experience of delirium in the intensive care unit: A qualitative interview study. | Bohart, S. Merete Moller, A. Forsyth Herling, S. | Intensive Crit Care Nurs | 2019 |
Delirium |