What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Common molecular and pathophysiological underpinnings of delirium and Alzheimer's disease: molecular signatures and therapeutic indications
- Authors
- Mosharaf, M. P. Alam, K. Gow, J. Mahumud, R. A. Mollah, M. N. H.
- Year
- 2024
- Journal
- BMC Geriatr
- Abstract
BACKGROUND: Delirium and Alzheimer’s disease (AD) are common causes of cognitive dysfunction among older adults. These neurodegenerative diseases share a common and complex relationship, and can occur individually or concurrently, increasing the chance of permanent mental dysfunction. However, the common molecular pathophysiology, key proteomic biomarkers, and functional pathways are largely unknown, whereby delirium is superimposed on AD and dementia. METHODS: We employed an integrated bioinformatics and system biology analysis approach to decipher such common key proteomic signatures, pathophysiological links between delirium and AD by analyzing the gene expression data of AD-affected human brain samples and comparing them with delirium-associated proteins. The present study identified the common drug target hub-proteins examining the protein-protein interaction (PPI) and gene regulatory network analysis. The functional enrichment and pathway analysis was conducted to reveal the common pathophysiological relationship. Finally, the molecular docking and dynamic simulation was used to computationally identify and validate the potential drug target and repurposable drugs for delirium and AD. RESULTS: We detected 99 shared differentially expressed genes (sDEGs) associated with AD and delirium. The sDEGs-set enrichment analysis detected the transmission across chemical synapses, neurodegeneration pathways, neuroinflammation and glutamatergic signaling pathway, oxidative stress, and BDNF signaling pathway as the most significant signaling pathways shared by delirium and AD. The disease-sDEGs interaction analysis highlighted the other disease risk factors with delirium and AD development and progression. Among the sDEGs of delirium and AD, the top 10 hub-proteins including ALB, APP, BDNF, CREB1, DLG4, GAD1, GAD2, GFAP, GRIN2B and GRIN2A were found by the PPI network analysis. Based on the maximum molecular docking binding affinities and molecular dynamic simulation (100 ns) results, the ALB and GAD2 were found as prominent drug target proteins when tacrine and donepezil were identified as potential drug candidates for delirium and AD. CONCLUSION: The study outlined the common key biomolecules and biological pathways shared by delirium and AD. The computationally reported potential drug molecules need a deeper investigation including clinical trials to validate their effectiveness. The outcomes from this study will help to understand the typical pathophysiological relationship between delirium and AD and flag future therapeutic development research for delirium.
- PMID
PMID: 39210294
PMICD: PMC11363673
- Keywords
Humans
*Alzheimer Disease/genetics/metabolism
*Delirium
Molecular Docking Simulation/methods
Aged
Computational Biology/methods
Protein Interaction Maps/physiology
Proteomics/methods
Biomarkers
Alzheimer’s disease
Common signaling pathways
Delirium
Drug repurposing
Essential drug targets
Molecular docking simulation
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Evaluation of the Efficacy and Safety of Quetiapine in the Treatment of Delirium in Adult ICU Patients: A Retrospective Comparative Study | Alghadeer, S. Almesned, R. S. Alshehri, E. A. Alwhaibi, A. | J Clin Med | 2024 |
Icu |
| Prolonged delirium during hospitalization is associated with worse long-term and short-term outcomes in patients with acute heart failure | Aikawa, Y. Ogata, S. Honda, S. Nagai, T. Murata, S. Morii, I. Anzai, T. Nishimura, K. Noguchi, T. | Int J Cardiol | 2024 |
Humans |
| Safety Analysis of Bapineuzumab in the Treatment of Mild to Moderate Alzheimer's Disease: A Systematic Review and Meta-Analysis | Gao, Y. Guo, J. Zhang, F. Li, Y. | Comb Chem High Throughput Screen | 2024 |
Humans |
| Biomarkers of neurodegeneration and neural injury as potential predictors for delirium | Fong, T. G. Vasunilashorn, S. M. Kivisäkk, P. Metzger, E. D. Schmitt, E. M. Marcantonio, E. R. Jones, R. N. Shanes, H. T. Arnold, S. E. Inouye, S. K. Ngo, L. H. | Int J Geriatr Psychiatry | 2024 |
Humans |
| Effectiveness and safety of second-generation antipsychotics for psychiatric disorders apart from schizophrenia: A systematic review and meta-analysis | Feng, X. Z. Li, Z. Li, Z. Y. Wang, K. Tan, X. Zhao, Y. Y. Mi, W. F. Zhu, W. L. Bao, Y. P. Lu, L. Li, S. X. | Psychiatry Res | 2024 |
Humans |
| Prevalence of Delirium After Abdominal Surgery and Association With Ketamine: A Retrospective, Propensity-Matched Cohort Study | Faisal, H. Qamar, F. Hsu, E. S. Xu, J. Lai, E. C. Wong, S. T. Masud, F. N. | Crit Care Explor | 2024 |
critical care |
| CRP/albumin, Glasgow prognostic score, and prognostic nutritional index as a predictor of mortality among delirium patients | Doğan, R. B. Yavuz, B. G. Satilmis, D. Afacan, M. A. Colak, S. | Ir J Med Sci | 2024 |
Humans |
| DeltaScan for the Assessment of Acute Encephalopathy and Delirium in ICU and non-ICU Patients, a Prospective Cross-Sectional Multicenter Validation Study | Ditzel, F. L. Hut, S. C. A. van den Boogaard, M. Boonstra, M. Leijten, F. S. S. Wils, E. J. van Nesselrooij, T. Kromkamp, M. Rood, P. J. T. Röder, C. Bouvy, P. F. Coesmans, M. Osse, R. J. Pop-Purceleanu, M. van Dellen, E. Krulder, J. W. M. Milisen, K. Fa | Am J Geriatr Psychiatry | 2023 |
Acute encephalopathy |
| Development of a complex intervention to prevent delirium in older hospitalized patients by optimizing discharge and transfer processes and involving caregivers: A multi-method study | Denninger, N. E. Brefka, S. Skudlik, S. Leinert, C. Mross, T. Meyer, G. Sulmann, D. Dallmeier, D. Denkinger, M. Müller, M. | Int J Nurs Stud | 2024 |
Humans to influence the work reported in this paper. |
| Performance and validation of two ICU delirium assessment and severity tools; a prospective observational study | den Boogaard, M. V. Leenders, M. Pop-Purceleanu, M. Tilburgs, B. | Intensive Crit Care Nurs | 2024 |
Assessment |
| "Beyond Feasibility": A Qualitative Study of Patients, Their Whānau (Family) and Staff Perspectives and Experiences of a Non- Pharmacological Delirium-Prevention Intervention in Two Aotearoa/New Zealand Hospices | Davies, C. Basire, K. Jones, V. Gillmore, D. Hosie, A. Gourley, A. Collier, A. | J Pain Symptom Manage | 2024 |
Hospice |
| Does ICU admission dysphagia independently contribute to delirium risk in ischemic stroke patients? Results from a cohort study | Cheng, H. Song, S. Tang, Y. Yuan, S. Huang, X. Ling, Y. Wang, Z. Tian, X. Lyu, J. | BMC Psychiatry | 2024 |
Adult |
| Development and validation of a delirium care critical-thinking scale for intensive care unit nurses: A mixed-method study | Chang, Y. L. Hsieh, M. J. Pan, C. I. Shang, S. T. Tsai, Y. F. | J Clin Nurs | 2024 |
Delphi method |
| Mapping the trajectory of acute mild-stroke cognitive recovery using serial computerised cognitive assessment | Campbell, A. Gustafsson, L. Grimley, R. Gullo, H. Rosbergen, I. Summers, M. | Brain Impair | 2023 |
Humans, Aged, Brain Ischemia, Stroke/complications |
| Risk factors for postoperative delirium in orthopaedic hip surgery patients: a database review | Callan, K. T. Donnelly, M. Lung, B. McLellan, M. DiGiovanni, R. McMaster, W. Yang, S. Stitzlein, R. | BMC Musculoskelet Disord | 2024 |
Humans, Emergence Delirium/complications, Orthopedics, Proximal Femoral Fractures, Postoperative Complications/epidemiology/etiology, Risk Factors, Arthroplasty, Replacement, Hip/adverse effects, Osteoarthritis/complications, Retrospective Studies, Delirium, Hip fracture, Osteoarthritis, Total hip arthroplasty |
| Association of perioperative plasma concentration of neurofilament light with delirium after cardiac surgery: a nested observational study | Brown, C. H. Kim, A. S. Yanek, L. Lewis, A. Mandal, K. Le, L. Tian, J. Neufeld, K. J. Hogue, C. Moghekar, A. | Br J Anaesth | 2024 |
Humans |
| Advancing specificity in delirium: The delirium subtyping initiative | Bowman, E. M. L. Brummel, N. E. Caplan, G. A. Cunningham, C. Evered, L. A. Fiest, K. M. Girard, T. D. Jackson, T. A. LaHue, S. C. Lindroth, H. L. Maclullich, A. M. J. McAuley, D. F. Oh, E. S. Oldham, M. A. Page, V. J. Pandharipande, P. P. Potter, K. M. Si | Alzheimers Dement | 2024 |
Humans |
| Cognitive impairment in critically ill patients and former critically ill patients: A concept analysis | Bødker Hanifa, A. L. Svenningsen, H. Møller, A. N. Dreyer, P. Holm, A. | Aust Crit Care | 2024 |
Humans, Critical Illness/rehabilitation, Quality of Life, Cognitive Dysfunction |
| Effects of structured protocolized physical therapy on the duration of mechanical ventilation in patients with prolonged weaning | Bickenbach, J. Fritsch, S. Cosler, S. Simon, Y. Dreher, M. Theisen, S. Kao, J. Hildebrand, F. Marx, G. Simon, T. P. | J Crit Care | 2024 |
Humans, Respiration, Artificial/adverse effects, Ventilator Weaning/methods, Hand Strength, Critical Illness/therapy, Time Factors, Intensive Care Units, Physical Therapy Modalities, ICU-acquired weakness, Mechanical ventilation, Physiotherapy, Prolonged weaning |
| The Utilization of Preoperative Steroids Safely Decreases the Risk of Postoperative Delirium in Geriatric Patients after Hip Fracture Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Baumann, A. N. Talaski, G. M. Uhler, M. A. Anastasio, A. T. Walley, K. C. Pean, C. A. Tampi, R. R. Farivar, M. | J Orthop Trauma | 2024 |
geriatric, postoperative delirium, hip fracture, steroids |
| Nomogram to predict the incidence of delirium in elderly patients with non-severe SARS-CoV-2 infection | An, G. Mi, Z. Hong, D. Ou, D. Cao, X. Liu, Q. Xiong, L. Li, C. | Front Psychiatry | 2023 |
Omicron |
| Practical Application of a Battery of Brief Tools to Evaluate Geriatric Medical Inpatients for the Three Ds | Alviz Núñez, M. Villa García, M. M. Gonzalez, M. C. Urrea, M. B. Velásquez-Tirado, J. D. Ocampo, M. V. Trzepacz, P. T. Franco, J. G. | J Neuropsychiatry Clin Neurosci | 2024 |
Humans, Aged, Delirium/diagnosis/epidemiology/psychology, Dementia/diagnosis/epidemiology/psychology, Inpatients, Cross-Sectional Studies, Ddt, Comorbidity, Delirium, Dementia, Depression, Geriatric Neuropsychiatry, The 3 Ds |
| Preoperative electroencephalographic alpha-power changes with eyes opening are associated with postoperative attention impairment and inattention-related delirium severity | Acker, L. Wong, M. K. Wright, M. C. Reese, M. Giattino, C. M. Roberts, K. C. Au, S. Colon-Emeric, C. Lipsitz, L. A. Devinney, M. J. Browndyke, J. Eleswarpu, S. Moretti, E. Whitson, H. E. Berger, M. Woldorff, M. G. | Br J Anaesth | 2024 |
Humans, Electroencephalography, Cognitive Dysfunction, Cognition, Emergence, Delirium/diagnosis, Attention, Postoperative Complications/diagnosis, alpha attenuation, delirium, eyes opening, postoperative delirium |
| Ketofol versus Dexmedetomidine for preventing postoperative delirium in elderly patients undergoing intestinal obstruction surgeries: a randomized controlled study | Abd Ellatif, S. E. Mowafy, S. M. S. Shahin, M. A. | BMC Anesthesiol | 2024 |
Humans, Aged, Emergence Delirium/epidemiology/prevention & control, Dexmedetomidine/therapeutic use, Prospective Studies, Propofol, Postoperative Complications/epidemiology/prevention & control/chemically induced, Double-Blind Method, Dexmedetomidine, Elderly patients, Intestinal obstruction surgeries, Ketofol, Postoperative delirium |
| Delirium is associated with loss of feedback cortical connectivity | Gjini, K. Casey, C. Kunkel, D. Her, M. Banks, M. I. Pearce, R. A. Lennertz, R. Sanders, R. D. | Alzheimers Dement | 2024 |
Humans, Feedback, Evoked Potentials, Auditory/physiology, Electroencephalography, Inflammation, Delirium |
| Impact of delirium on acute stroke outcomes: A systematic review and meta-analysis | Gong, X. Jin, S. Zhou, Y. Lai, L. Wang, W. | Neurol Sci | 2024 |
Acute stroke, Encephalopathy, Functional outcomes, Hospital admission, Mortality, Post-stroke delirium, Readmission rate |
| The prognostic validity of delirium severity as measured by Delirium Observation Screening Scale (DOS scale) on adverse outcomes | Gray, E. A. Ranasinghe, C. Lin, H. S. | Australas J Ageing | 2024 |
confusion, delirium, frailty, morbidity, prognosis |
| The Relationship Between Uncertainty and Psychological Distress Among Family Caregivers of Patients With Delirium in Intensive Care Units: A Cross-Sectional Survey | Haji Assa, A. Cao, X. Boehm, L. M. Umberger, R. A. Carter, M. A. | Dimens Crit Care Nurs | 2024 |
Adult, Humans, Caregivers, Cross-Sectional Studies, Uncertainty, Intensive Care Units, Family/psychology, Psychological Distress, Delirium, Stress, Psychological |
| The Relationship Between Uncertainty and Psychological Distress Among Family Caregivers of Patients With Delirium in Intensive Care Units: A Cross-Sectional Survey | Haji Assa, A. Cao, X. Boehm, L. M. Umberger, R. A. Carter, M. A. | Dimens Crit Care Nurs | 2024 |
Adult, Humans, Caregivers, Cross-Sectional Studies, Uncertainty, Intensive Care Units, Family/psychology, Psychological Distress Delirium, Stress, Psychological |
| Effects of liposomal bupivacaine in preoperative fascia iliac block on postoperative pain and delirium in elderly patients undergoing hip fracture surgery: a study protocol for a randomised, parallel controlled prospective clinical study | Hao, Y. Li, W. Zheng, M. Li, X. Wu, X. Yu, Z. Liu, S. Li, J. Xu, H. | BMJ Open | 2024 |
Aged, Humans, Prospective Studies, China, Hip Fractures/surgery |
| Delirium Prevention in Early Rehabilitation During Acute Hospitalization and Implementation of Programs Specifically Tailored to Older Patients with Cognitive Impairment: A Scoping Review with Meta-Analysis | Hauer, K. Dutzi, I. Werner, C. Bauer, J. Ullrich, P. | J Alzheimers Dis | 2024 |
Humans, Aged, Aged, 80 and over, Delirium/prevention & control/epidemiology |
| Association Between Preoperative Long-Term Poor Sleep Quality and Postoperative Delirium in Elderly Patients Undergoing Cardiac Surgery: A Multi-Center Observational Study | Huang, Z. Huang, C. Deng, Y. Lu, H. Shi, L. | Am Surg | 2024 |
Postoperative delirium, cardiac surgery, elderly patients, preoperative sleep quality, sleep disorders |
| Ishibashi, Y. Sogawa, R. Ogata, K. Matsuoka, A. Yamada, H. Murakawa-Hirachi, T. Mizoguchi, Y. Monji, A. Shimanoe, C. | Association Between Antidiabetic Drugs and Delirium: A Study Based on the Adverse Drug Event Reporting Database in Japan | Clin Drug Investig | 2024 |
Humans, Hypoglycemic Agents/adverse effects, Japan/epidemiology, Diabetes Mellitus/chemically induced/drug therapy/epidemiology, Drug-Related Side Effects and Adverse Reactions, Sulfonylurea Compounds/adverse effects, Insulin, Delirium/chemically induced/epidemiology, Adverse Drug Reaction Reporting Systems |
| Gene networks for use in metabolomic data analysis of blood plasma from patients with postoperative delirium | Ivanisenko, V. A. Basov, N. V. Makarova, A. A. Venzel, A. S. Rogachev, A. D. Demenkov, P. S. Ivanisenko, T. V. Kleshchev, M. A. Gaisler, E. V. Moroz, G. B. Plesko, V. V. Sotnikova, Y. S. Patrushev, Y. V. Lomivorotov, V. V. Kolchanov, N. A. Pokrovsky, A. G | Vavilovskii Zhurnal Genet Selektsii | 2023 |
ANDSystem, Lc-ms/ms, biomarkers, cardiac surgery, gene networks, lipidomics, metabolomics, postoperative delirium, sphingolipids |
| Serum neurofilament light and postoperative delirium in cardiac surgery: a preplanned secondary analysis of a prospective observational study | Khalifa, C. Robert, A. Cappe, M. Lemaire, G. Tircoveanu, R. Dehon, V. Ivanoiu, A. Piérard, S. de Kerchove, L. Jacobs Sariyar, A. Teunissen, C. E. Momeni, M. | Anesthesiology | 2024 |
delirium, postoperative, cognitive function, serum neurofilament, cardiac surgery |
| Differential effects of sevoflurane and desflurane on frontal intraoperative electroencephalogram dynamics associated with postoperative delirium | Kim, Y. S. Kim, J. Park, S. Kim, K. N. Ha, Y. Yi, S. Shin, D. A. Kuh, S. U. Lee, C. K. Koo, B. N. Kim, S. E. | J Clin Anesth | 2024 |
Humans, Aged, Sevoflurane/adverse effects, Desflurane/adverse effects, Anesthetics, Inhalation/adverse effects, Emergence Delirium/chemically induced, Isoflurane/adverse effects, Methyl Ethers/adverse effects, Electroencephalography, Delirium, Desflurane, Electroencephalogram, Prefrontal connectivity, Sevoflurane |
| Machine learning methods for developing a predictive model of the incidence of delirium in cardiac intensive care units | Ko, R. E. Lee, J. Kim, S. Ahn, J. H. Na, S. J. Yang, J. H. | Rev Esp Cardiol (Engl Ed) | 2024 |
Cardiac intensive care unit, Delirium prediction, Machine learning, Risk model |
| Target flow deviations on the cardiopulmonary bypass cause postoperative delirium in cardiothoracic surgery-a retrospective study evaluating temporal fluctuations of perfusion data | Krefting, J. Gorki, H. Hoenicka, M. Albrecht, G. Kraft, R. Liebold, A. | Interdiscip Cardiovasc Thorac Surg | 2024 |
Algorithm-based data processing, Cardiac surgery, Cardiopulmonary bypass, Postoperative delirium, Target flow deviations |
| Comparative evaluation of intraoperative dexmedetomidine versus lidocaine for reducing postoperative cognitive decline in the elderly: a prospective randomized controlled trial | Kurup, M. T. Sarkar, S. Verma, R. Bhatia, R. Khanna, P. Maitra, S. Anand, R. Ray, B. R. Singh, A. K. Deepak, K. K. | Anaesthesiol Intensive Ther | 2023 |
Aged, Humans, Anesthetics, Inhalation, Delirium, Dexmedetomidine/therapeutic use, Interleukin-1, Interleukin-6, Lidocaine/therapeutic use, Postoperative Cognitive Complications/prevention & control, Postoperative, Complications/epidemiology/prevention & control, Prospective Studies, Middle,, Aged, Aged, 80 and over, dexmedetomidine, elderly, lidocaine, postoperative cognitive dysfunction, abdominal surgery |
| The effectiveness of preoperative delirium prevention in intermediate to high-risk older surgical patients: A systematic review | Lay, N. Foley, P. Allen, J. | J Clin Nurs | 2024 |
older adults, older surgical patients, preoperative delirium prevention, systematic review |
| Predictive Value of the Duke Anesthesia Resistance Scale in Postoperative Delirium among Elderly Patients with Hip Fractures | Lei, Z. Zhang, L. Yang, J. Ye, L. Xia, L. | Altern Ther Health Med | 2024 |
postoperative delirium, elderly, hip fracture, anesthesia resistance, delirium |
| A machine learning-based prediction model for postoperative delirium in cardiac valve surgery using electronic health records | Li, Q. Li, J. Chen, J. Zhao, X. Zhuang, J. Zhong, G. Song, Y. Lei, L. | BMC Cardiovasc Disord | 2024 |
Humans, Emergence Delirium, Electronic Health Records, Bayes Theorem, Cardiac Surgical Procedures/adverse effects, Heart Valves, Machine Learning, Cardiac valve surgery, Postoperative delirium, Prediction model, Random Forest Classifier |
| Promising Effects of Montelukast for Critically Ill Asthma Patients via a Reduction in Delirium | Li, Y. Zhang, M. Zhang, S. Yang, G. | Pharmaceuticals (Basel) | 2024 |
critical illness, delirium, leukotriene, montelukast |
| Is there a difference between preoperative and postoperative delirium in elderly hip fracture patients?: A retrospective case control study | Lim, C. Roh, Y. H. Park, Y. G. Lee, J. Nam, K. W. | Medicine (Baltimore) | 2024 |
Aged, Humans, Emergence Delirium, Retrospective Studies, Case-Control Studies, Hip Fractures/complications/surgery, Postoperative, Complications/epidemiology, Risk Factors |
| Effect of esketamine on postoperative analgesia and postoperative delirium in elderly patients undergoing gastrointestinal surgery | Liu, J. Wang, T. Song, J. Cao, L. | BMC Anesthesiol | 2024 |
Humans, Aged, Sufentanil, Pain, Postoperative/drug therapy/chemically induced, Emergence Delirium/drug therapy, Digestive System Surgical Procedures, Interleukin-6, Analgesia, Patient-Controlled, Anti-Inflammatory, Agents/therapeutic use, Analgesics, Opioid, Ketamine, Anti-inflammatory, Esketamine, Postoperative analgesia, Postoperative delirium |
| Association between human blood metabolome and the risk of delirium: a Mendelian Randomization study | Long, C. Lin, D. Zhang, L. Lin, Y. Yao, Q. Zhang, G. Li, L. Liu, H. Ying, J. Wang, X. Hua, F. | Front Endocrinol (Lausanne) | 2023 |
Humans, Aged, Cholesterol, LDL, Risk Factors, Mendelian Randomization, Analysis/methods, Genome-Wide Association Study/methods, Sphingomyelins, Delirium/genetics, Mendelian Randomization, delirium, genome-wide association study, metabolites, phenotype-wide study |
| Association of postoperative delirium with serum and cerebrospinal fluid proteomic profiles: a prospective cohort study in older hip fracture patients | Lozano-Vicario, L. Muñoz-Vázquez Á, J. Ramírez-Vélez, R. Galbete-Jiménez, A. Fernández-Irigoyen, J. Santamaría, E. Cedeno-Veloz, B. A. Zambom-Ferraresi, F. Van Munster, B. C. Ortiz-Gómez, J. R. Hidalgo-Ovejero Á, M. Romero-Ortuno, R. Izquierdo, | Geroscience | 2024 |
Biomarkers, Cxcl9, Cognitive impairment, Delirium, Hip fracture, Neuroinflammation |
| Risk factors for postoperative delirium in patients with Stanford type A aortic dissection: a systematic review and meta-analysis | Lu, S. Jiang, Y. Meng, F. Xie, X. Wang, D. Su, Y. | J Cardiothorac Surg | 2024 |
Humans, Emergence Delirium, Risk Factors, Aortic Dissection/surgery, Renal Insufficiency, Azides, Deoxyglucose/*analogs & derivatives, Aortic dissection, Delirium, Meta-analysis, Risk factor |
| Exploring patients' and families' preferences for auditory stimulation in ICU delirium prevention: A qualitative study | Ma, Y. Cui, N. Guo, Z. Zhang, Y. Jin, J. | Intensive Crit Care Nurs | 2024 |
critical care, Delirium, Intensive care units, Qualitative research |
| Development of Machine Learning Prediction Models for Self-Extubation After Delirium Using Emergency Department Data | Matsumoto, K. Nohara, Y. Sakaguchi, M. Takayama, Y. Yamashita, T. Soejima, H. Nakashima, N. | Stud Health Technol Inform | 2024 |
Humans, Airway Extubation, Emergency Service, Hospital, Machine Learning, Restraint, Physical, Delirium/diagnosis, delirium, self-extubation after delirium |
| Risk factors, preventive interventions, overlapping symptoms, and clinical measures of delirium in elderly patients | Mei, X. Liu, Y. H. Han, Y. Q. Zheng, C. Y. | World J Psychiatry | 2023 |
Clinical practice, delirium, Preventive interventions, Research progress, Review, Risk factors |
| Preoperative prognostic nutritional index value as a predictive factor for postoperative delirium in older adult patients with hip fractures: a secondary analysis | Mi, X. Jia, Y. Song, Y. Liu, K. Liu, T. Han, D. Yang, N. Wang, G. Guo, X. Yuan, Y. Li, Z. | BMC Geriatr | 2024 |
Humans, Aged, Nutrition Assessment, Emergence Delirium, Delirium/diagnosis/epidemiology/etiology, Prognosis, Prospective Studies, Cohort Studies, Postoperative Complications/diagnosis/epidemiology/etiology, Hip Fractures/complications/epidemiology/surgery, Risk Factors, Hip fracture, Nutritional status, Older adult patients, Postoperative delirium, Prognostic nutritional index |
| Long-term outcomes with haloperidol versus placebo in acutely admitted adult ICU patients with delirium | Mortensen, C. B. Andersen-Ranberg, N. C. Poulsen, L. M. Granholm, A. Rasmussen, B. S. Kjær, M. N. Lange, T. Ebdrup, B. H. Collet, M. O. Andreasen, A. S. Bestle, M. H. Uslu, B. Pedersen, H. S. Nielsen, L. G. Hästbacka, J. Jensen, T. B. Damgaard, K. Somme | Intensive Care Med | 2024 |
Adult, Humans, Delirium/drug therapy, Haloperidol/therapeutic use, Hospitalization, Intensive Care Units, Quality of Life |
| Association of sleep quality on the night of operative day with postoperative delirium in elderly patients: A prospective cohort study | Ou-Yang, C. L. Ma, L. B. Wu, X. D. Ma, Y. L. Liu, Y. H. Tong, L. Li, H. Lou, J. S. Cao, J. B. Mi, W. D. | Eur J Anaesthesiol | 2024 |
Aged, Humans, Male, Acute Kidney Injury, Cardiovascular Infections/complications, Delirium/diagnosis/epidemiology/etiology, Emergence Delirium/diagnosis/epidemiology/etiology, Postoperative, Complications/diagnosis/epidemiology/etiology, Prospective Studies, Risk Factors, Sleep Quality, Stroke, Female |
| Multicentre implementation of a quality improvement initiative to reduce delirium in adult intensive care units: An interrupted time series analysis | Owen, V. S. Sinnadurai, S. Morrissey, J. Colaco, H. Wickson, P. Dyjur, D. Redlich, M. O'Neill, B. Zygun, D. A. Doig, C. J. Harris, J. Zuege, D. J. Stelfox, H. T. Faris, P. D. Fiest, K. M. Niven, D. J. | J Crit Care | 2024 |
Critical care, Delirium, Implementation science, Interrupted time series analysis, Patient care bundles |
| Preoperative mild cognitive impairment as a risk factor of postoperative cognitive dysfunction in elderly patients undergoing spine surgery | Park, S. Kim, J. Ha, Y. Kim, K. N. Yi, S. Koo, B. N. | Front Aging Neurosci | 2024 |
aged, cognitive dysfunction, delirium, neurocognitive disorders, perioperative care, postoperative cognitive complications |
| Association of preoperative blood glucose level with delirium after non-cardiac surgery in diabetic patients | Park, S. J. Oh, A. R. Lee, J. H. Yang, K. Park, J. | Korean J Anesthesiol | 2024 |
Acute hyperglycemia, Chronic hyperglycemia, Hyperglycemia, Mortality, Non-cardiac surgery, Postoperative delirium |
| Delirium detection tools show varying completion rates and positive score rates when used at scale in routine practice in general hospital settings: A systematic review | Penfold, R. S. Squires, C. Angus, A. Shenkin, S. D. Ibitoye, T. Tieges, Z. Neufeld, K. J. Avelino-Silva, T. J. Davis, D. Anand, A. Duckworth, A. D. Guthrie, B. MacLullich, A. M. J. | J Am Geriatr Soc | 2024 |
delirium, detection, geriatric assessment, hospitals, older people, routine data, systematic review |
| EEG biomarkers from anesthesia induction to identify vulnerable patients at risk for postoperative delirium | Pollak, M. Leroy, S. Röhr, V. Brown, E. N. Spies, C. Koch, S. | Anesthesiology | 2024 |
delirium, EEG, anesthesia, postoperative delirium, propofol |
| The prognosis of delirium in older outpatients | Quispel-Aggenbach, D. W. Zuidema, S. U. Luijendijk, H. J. | Psychogeriatrics | 2024 |
delirium, elderly, older patient, prevalence, prognosis, risk factors |
| Association of Postoperative Delirium With Incident Dementia and Graft Outcomes Among Kidney Transplant Recipients | Ruck, J. M. Chu, N. M. Liu, Y. Li, Y. Chen, Y. Mathur, A. Carlson, M. C. Crews, D. C. Chodosh, J. Segev, D. L. McAdams-DeMarco, M. | Transplantation | 2024 |
Humans, United States/epidemiology, Aged, Middle Aged, Kidney, Transplantation/adverse effects, Emergence Delirium/complications, Kidney Failure, Chronic/diagnosis/surgery/complications, Risk Factors, Transplant Recipients, Dementia/diagnosis/epidemiology/etiology, Graft Survival |
| Irreversible postoperative cognitive impairment after unruptured intracranial aneurysm treatment in the elderly | Sakurada, K. Ikedo, T. Hosokawa, Y. Sugasawa, S. Shimonaga, K. Kushi, Y. Niwa, A. Ozaki, S. Hattori, E. Y. Hamano, E. Yamada, K. Imamura, H. Mori, H. Iihara, K. Kataoka, H. | Acta Neurochir (Wien) | 2024 |
Aged, Humans, Middle Aged, Postoperative Cognitive Complications, Intracranial Aneurysm, Retrospective Studies, Cognition, Executive Function, Delirium, Older patient, Postoperative cognitive dysfunction, Postoperative cognitive recovery, Unruptured intracranial aneurysm |
| Random forest algorithm for predicting postoperative delirium in older patients | Sheng, W. Tang, X. Hu, X. Liu, P. Liu, L. Miao, H. Wang, D. Li, T. | Front Neurol | 2023 |
confusion matrix, older patient, partial dependence graph, postoperative delirium, random forest |
| Role of supplemental regional blocks on postoperative neurocognitive dysfunction after major non-cardiac surgeries: a systematic review and meta-analysis of randomized controlled trials | Singh, N. P. Makkar, J. K. Borle, A. Singh, P. M. | Reg Anesth Pain Med | 2024 |
Adult, Humans, Randomized Controlled Trials as Topic, Anesthesia, Conduction, Analgesia/methods, Delirium, Postoperative Cognitive, Complications/diagnosis/prevention & control, Outcome Assessment, Health Care, Pain, Postoperative, Treatment Outcome, analgesia |
| Early postoperative neurocognitive complications in elderly patients: comparing those with and without preexisting mild cognitive impairment- a prospective study | Somnuke, P. Srishewachart, P. Jiraphorncharas, C. Khempetch, A. Weeranithan, J. Suraarunsumrit, P. Srinonprasert, V. Siriussawakul, A. | BMC Geriatr | 2024 |
Aged, Humans, Prospective Studies, Postoperative, Complications/diagnosis/epidemiology/etiology, Cognitive, Dysfunction/diagnosis/epidemiology, Emergence Delirium, Postoperative Cognitive Complications/diagnosis/epidemiology/etiology, Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), Elderly, Mild cognitive impairment (MCI), Montreal Cognitive Assessment (MoCA), Postoperative cognitive dysfunction (POCD), Postoperative delirium (POD) |
| Prediction models for postoperative delirium in elderly patients with machine-learning algorithms and SHapley Additive exPlanations | Song, Y. Zhang, D. Wang, Q. Liu, Y. Chen, K. Sun, J. Shi, L. Li, B. Yang, X. Mi, W. Cao, J. | Transl Psychiatry | 2024 |
Aged, Humans, Emergence Delirium, Retrospective Studies, Algorithms, Hip Fractures/surgery, Machine Learning |
| Preoperative prognostic nutritional index predicts postoperative delirium in aged patients after surgery: A matched cohort study | Song, Y. X. Wang, Q. Ma, Y. L. Chen, K. S. Liu, M. Zhou, X. F. Zhao, H. Lou, J. S. Li, H. Liu, Y. H. Mi, W. D. Cao, J. B. | Gen Hosp Psychiatry | 2024 |
Humans, Aged, Nutrition Assessment, Emergence Delirium, Retrospective Studies, Prognosis, Cohort Studies, Nutritional Status, Aged patients, Biomarker, Postoperative delirium, Prognostic nutritional index |
| Investigating the correlation of delirium after cardiac surgery with memories and posttraumatic stress disorder consequences of intensive care unit: A prospective cohort study | Su, L. J. Chen, M. J. Yang, R. Zou, H. Chen, T. T. Li, S. L. Xin, H. N. Hu, R. F. | Intensive Crit Care Nurs | 2024 |
Cardiac surgery, Delirium, Intensive care unit, Memory, Posttraumatic stress disorder |
| Effect of Delirium on Interhospital Transfer Outcomes | Thomas, M. K. Kalivas, B. Zhang, J. Marsden, J. Mauldin, P. D. Moran, W. P. Hunt, K. Heincelman, M. | South Med J | 2024 |
Adult, Humans, Retrospective Studies, Patient Transfer, Hospitalization, Length of Stay, Hospital Mortality, Delirium/epidemiology, Emergency Service, Hospital |
| Impaired glucose utilization in the brain of patients with delirium following hip fracture | Titlestad, I. Watne, L. O. Caplan, G. A. McCann, A. Ueland, P. M. Neerland, B. E. Myrstad, M. Halaas, N. B. Pollmann, C. T. Henjum, K. Ranhoff, A. H. Solberg, L. B. Figved, W. Cunningham, C. Giil, L. M. | Brain | 2024 |
Humans, Aged, 80 and over, Glucose/metabolism, Acetoacetates |
| Types, predictors, and consequences of medicines related problems (MRPs) in frail older adults admitted to hospital from primary care - A retrospective cohort study | Ude-Okeleke, R. C. Aslanpour, Z. Dhillon, S. Berry, R. Bines, E. Umaru, N. | Explor Res Clin Soc Pharm | 2024 |
Delirium, Deterioration, Frailty, Hospitalization, MRPs, Older people, Primary care |
| Development and Usability Testing of a Mobile App-Based Clinical Decision Support System for Delirium: Randomized Crossover Trial | Wang, J. Ji, M. Han, Y. Wu, Y. | JMIR Aging | 2024 |
Humans, Aged, Delirium/diagnosis, Cross-Over Studies, Mobile Applications, Decision Support Systems, Clinical, User-Centered Design, User-Computer, Interface, Reproducibility of Results, 3-Minute Diagnostic Interview for Confusion Assessment Method-Defined Delirium, 3d-cam, clinical decision, support system, delirium, nurse, older adults |
| Risk factors for dementia in older intensive care unit (ICU) survivors | Wang, S. Perkins, A. J. Chi, R. Yates, B. A. Khan, S. H. Gao, S. Boustani, M. Khan, B. A. | Alzheimers Dement | 2024 |
Humans, Female, Aged, Middle Aged, Male, Delirium/epidemiology/etiology, Prospective Studies, Intensive Care Units, Risk Factors, Stroke/complications, Dementia/epidemiology/complications, Survivors, Alzheimer’s disease, critical illness, delirium, dementia, depression, intensive care unit, stroke |
| Geriatric nutritional risk index independently predicts delirium in older patients in intensive care units: A multicenter cohort study | Wei, F. Cheng, H. He, R. Yang, X. Hu, Z. Lyu, J. Wang, Y. | Arch Gerontol Geriatr | 2024 |
Humans, Aged, Nutritional Status, Malnutrition/complications/diagnosis/epidemiology, Nutrition Assessment |
| The RAPID-score: Risk Assessment and PredIction of Delirium in acute stroke patients based on very early clinical parameters | Wischmann, J. Kremer, P. Hinske, L. Tomasi, R. Becker-Pennrich, A. S. Kellert, L. | Front Neurol | 2023 |
acute stroke, delirium, intensive care unit, post-stroke delirium, prediction score, stroke unit |
| Assessing patterns of delirium symptoms reveals a novel subtype among elective surgical patients with postoperative delirium | Yang, L. Do, Q. Zhu, X. Leung, J. M. Sands, L. P. | Int J Geriatr Psychiatry | 2024 |
Humans, Emergence Delirium/complications, Delirium/diagnosis/epidemiology/etiology, Postoperative, Complications/epidemiology, Psychomotor Agitation/diagnosis, Elective Surgical Procedures/adverse effects, Risk Factors, aging, delirium subtypes, elective surgery, postoperative delirium |
| Efficacy of dexmedetomidine combined with ropivacaine on postoperative analgesia and delirium in elderly patients with total knee arthroplasty | Ye, Z. H. Li, Y. Wu, X. P. Yu, Z. Ma, Z. R. Hai, K. R. Ye, Q. S. | J Robot Surg | 2024 |
Aged, Humans, Arthroplasty, Replacement, Knee/adverse effects, Dexmedetomidine/therapeutic use, Ropivacaine, Emergence Delirium, Robotic Surgical Procedures/methods, Analgesia, Dexmedetomidine, Postoperative analgesia, Postoperative delirium, Total knee arthroplasty |
| Delirium is associated with failure to rescue after cardiac surgery | A. M. Strobel, R. J. Kaplan, E. Norman, A. V. Ahmad, R. Kern, J. Yarboro, L. Yount, K. Hulse, M. Teman, N. R. | JTCVS OpenYoung | 2023 |
delirium, failure to rescue, perioperative care, CAM ICU, cardiac surgery |
| The Effect of Central Sensitization on Postoperative Neurocognitive Dysfunction in Hospitalized Elderly Patients: A Prospective Cohort Clinical Trial | Yu, L. Yang, D. Zhou, Q. Yin, C. Zhang, Q. Li, W. Yu, J. Wang, Q. | Exp Aging Res | 2024 |
Aged, Humans, Central Nervous System Sensitization, Prospective Studies, Aging, Propofol, Mental Status and Dementia Tests |
| Peripheral nerve block and cognitive impairment after thoracic surgery: a systematic review and meta-analysis | Zhang, Y. Liu, M. He, J. Zhang, H. Zhang, M. Li, J. | Minerva Anestesiol | 2024 |
postoperative cognitive impairment, cognitive dysfunction, thoracic surgery, nerve block, surgery |
| Preoperative cognitive training improves postoperative cognitive function: a meta-analysis and systematic review of randomized controlled trials | Zhao, L. Guo, Y. Zhou, X. Mao, W. Li, L. | Front Neurol | 2023 |
cognitive function training, cognitive training, meta-analysis, perioperative neurocognitive disorders, postoperative cognitive dysfunction, postoperative delirium |
| Enhancing delirium assessment and management through nursing education interventions: A scoping review | Zhao, Y. Missbrenner, N. Xu, H. D. Josephson, J. | Nurse Educ Pract | 2024 |
Delirium assessment, Delirium management, Nurse education, Nursing education intervention |
| Enhancing delirium assessment and management through nursing education interventions: A scoping review | Zhao, Y. Missbrenner, N. Xu, H. D. Josephson, J. | Nurse Educ Pract | 2024 |
Delirium assessment |
| Different Sedation Strategies in Older Patients Receiving Spinal Anesthesia for Hip Surgery on Postoperative Delirium: A Randomized Clinical Trial | Zhu, S. Liu, Y. Wang, X. Wang, L. Li, J. Xue, X. Li, Z. Liu, J. Liu, X. Zhao, S. | Drug Des Devel Ther | 2023 |
Humans, Aged, Propofol/adverse effects, Emergence Delirium, Hypnotics and Sedatives/adverse effects, Dexmedetomidine/adverse effects, Anesthesia, Spinal/adverse effects, Delirium/etiology, Postoperative Complications/epidemiology, anesthetics, hip surgery, propofol, spinal anesthesia |
| Frailty and post-operative delirium influence on functional status in patients with hip fracture: the GIOG 2.0 study | Gandossi, C. M. Zambon, A. Ferrara, M. C. Tassistro, E. Castoldi, G. Colombo, F. Mussi, C. Martini, E. Sergi, G. Coin, A. Zatti, G. Trevisan, C. Volpato, S. Ungar, A. Bellelli, G. | Aging Clin Exp Res | 2023 |
Humans |
| Associations between Alzheimer's disease biomarkers and postoperative delirium or cognitive dysfunction: A meta-analysis and trial sequential analysis of prospective clinical trials | Geng, J. Zhang, Y. Chen, H. Shi, H. Wu, Z. Chen, J. Luo, F. | Eur J Anaesthesiol | 2023 | |
| Delirium in oncological palliative care and clinical cardiology units: A comparative analysis | Grisales, E. S. Higuita, A. M. Correa, M. E. Gómez, J. J. V. González, C. P. Daveloza, A. K. Vásquez, J. G. F. | Palliat Support Care |
Humans |
|
| Risk Factors and Associated Outcomes of Postoperative Delirium After Open Abdominal Aortic Aneurysm Repair | Gutierrez, R. D. Smith, E. J. T. Matthay, Z. A. Gasper, W. J. Hiramoto, J. S. Conte, M. S. Finlayson, E. Walter, L. C. Iannuzzi, J. C. | J Vasc Surg | 2023 |
abdominal aortic aneurysm (AAA) |
| Effect of preoperative sleep disorders on delirium in proximal femoral surgery patients aged 60 or older | Han, F. Liu, X. Huang, H. Chu, H. Feng, W. | BMC Anesthesiol | 2023 |
Humans |
| Electroencephalogram measured functional connectivity for delirium detection: a systematic review | Hanna, A. Jirsch, J. Alain, C. Corvinelli, S. Lee, J. S. | Front Neurosci | 2023 |
Eeg |
| Development and evaluation of a concise nurse-driven non-pharmacological delirium reduction workflow for hospitalized patients: An interrupted time series study | Harrison, J. D. Rathfon, M. Binford, S. Miranda, J. Oreper, S. Holt, B. Rogers, S. E. | Geriatr Nurs | 2023 |
Delirium |
| Predicting postoperative delirium after cardiovascular surgeries from preoperative portable electroencephalography oscillations | Hata, M. Miyazaki, Y. Nagata, C. Masuda, H. Wada, T. Takahashi, S. Ishii, R. Miyagawa, S. Ikeda, M. Ueno, T. | Front Psychiatry | 2023 |
Eeg |
| Lower alpha frequency of intraoperative frontal EEG is associated with postoperative delirium: A secondary propensity-matched analysis | Hight, D. Ehrhardt, A. Lersch, F. Luedi, M. M. Stüber, F. Kaiser, H. A. | J Clin Anesth | 2023 |
Alpha rhythm |
| Inflammatory and nutritional markers predict the risk of post-operative delirium in elderly patients following total hip arthroplasty | Hu, W. Song, Z. Shang, H. Wang, J. Hao, Y. | Front Nutr | 2023 |
inflammatory markers |
| Evaluation of brain nerve function in ICU patients with Delirium by deep learning algorithm-based resting state MRI | Huang, X. Jiang, R. Peng, S. Wei, Y. Hu, X. Chen, J. Lian, W. | Open Life Sci | 2023 |
brain nerve function |
| Prevention and treatment of traumatic brain injury-related delirium: a systematic review | Huang, Y. Q. Weiss, S. Gros, P. Wong, E. Piché, P. P. Vyas, M. V. Tam, A. K. H. Watt, J. A. | J Neurol | 2023 |
Humans |
| The Efficacy of Dexmedetomidine alone or with Melatonin on Delirium after Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial | Javaherforooshzadeh, F. Babazadeh Dezfoli, A. Saki Malehi, A. Gholizadeh, B. | Anesth Pain Med | 2023 |
Cardiac Surgery |
| Cerebral autoregulation-based mean arterial pressure targets and delirium in critically ill adults without brain injury: a retrospective cohort study | Khan, J. M. Shore, A. Lee, K. F. H. Wood, M. D. Maslove, D. M. Hunt, M. Georgescu, I. Muscedere, J. Boyd, J. G. | Can J Anaesth | 2023 |
cerebral autoregulation |
| Clinical Features of Delirium among Patients in the Intensive Care Unit According to Motor Subtype Classification: A Retrospective Longitudinal Study | Kim, J. Oh, J. Ahn, J. S. Chung, K. Kim, M. K. Shin, C. S. Park, J. Y. | Yonsei Med J | 2023 |
Humans |
| The Efficacy of Ramelteon to Prevent Postoperative Delirium After General Anesthesia in the Elderly: A Double-Blind, Randomized, Placebo-Controlled Trial | Kinouchi, M. Mihara, T. Taguri, M. Ogura, M. | Am J Geriatr Psychiatry | 2023 |
Aged |