What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Interventions for preventing intensive care unit delirium in adults.
- Authors
- Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T.
- Year
- 2018
- Journal
- Cochrane Database of Systematic Reviews
- Abstract
Background: Delirium is defined as a disturbance in attention, awareness and cognition with reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the environment. Critically ill patients in the intensive care unit (ICU) frequently develop ICU delirium. It can profoundly affect both them and their families because it is associated with increased mortality, longer duration of mechanical ventilation, longer hospital and ICU stay and long-term cognitive impairment. It also results in increased costs for society. Objectives: To assess existing evidence for the effect of preventive interventions on ICU delirium, in-hospital mortality, the number of delirium- and coma-free days, ventilator-free days, length of stay in the ICU and cognitive impairment. Search methods: We searched CENTRAL, MEDLINE, Embase, BIOSIS, International Web of Science, Latin American Caribbean Health Sciences Literature, CINAHL from 1980 to 11 April 2018 without any language limits. We adapted the MEDLINE search for searching the other databases. Furthermore, we checked references, searched citations and contacted study authors to identify additional studies. We also checked the following trial registries: Current Controlled Trials; ClinicalTrials.gov; and CenterWatch.com (all on 24 April 2018). Selection criteria: We included randomized controlled trials (RCTs) of adult medical or surgical ICU patients receiving any intervention for preventing ICU delirium. The control could be standard ICU care, placebo or both. We assessed the quality of evidence with GRADE. Data collection and analysis: We checked titles and abstracts to exclude obviously irrelevant studies and obtained full reports on potentially relevant ones. Two review authors independently extracted data. If possible we conducted meta-analyses, otherwise we synthesized data narratively. Main results: The electronic search yielded 8746 records. We included 12 RCTs (3885 participants) comparing usual care with the following interventions: commonly used drugs (four studies); sedation regimens (four studies); physical therapy or cognitive therapy, or both (one study); environmental interventions (two studies); and preventive nursing care (one study). We found 15 ongoing studies and five studies awaiting classification. The participants were 48 to 70 years old; 48% to 74% were male; the mean acute physiology and chronic health evaluation (APACHE II) score was 14 to 28 (range 0 to 71; higher scores correspond to more severe disease and a higher risk of death). With the exception of one study, all participants were mechanically ventilated in medical or surgical ICUs or mixed. The studies were overall at low risk of bias. Six studies were at high risk of detection bias due to lack of blinding of outcome assessors. We report results for the two most commonly explored approaches to delirium prevention: pharmacologic and a non-pharmacologic intervention. Haloperidol versus placebo (two RCTs, 1580 participants) The event rate of ICU delirium was measured in one study including 1439 participants. No difference was identified between groups, (risk ratio (RR) 1.01, 95% confidence interval (CI) 0.87 to 1.17) (moderate-quality evidence). Haloperidol versus placebo neither reduced or increased in-hospital mortality, (RR 0.98, 95% CI 0.80 to 1.22; 2 studies; 1580 participants (moderate-quality evidence)); the number of delirium- and coma-free days, (mean difference (MD) -0.60, 95% CI -1.37 to 0.17; 2 studies, 1580 participants (moderate-quality of evidence)); number of ventilator-free days (mean 23.8 (MD -0.30, 95% CI -0.93 to 0.33) 1 study; 1439 participants, (high-quality evidence)); length of ICU stay, (MD 0.18, 95% CI -0.60 to 0.97); 2 studies, 1580 participants; high-quality evidence). None of the studies measured cognitive impairment. In one study there were three serious adverse events in the intervention group and five in the placebo group; in the other there were five serious adverse events and three patients died, one in each group. None of the serious adverse eve ts were judged to be related to interventions received (moderate-quality evidence). Physical and cognitive therapy interventions (one study, 65 participants) The study did not measure the event rate of ICU delirium. A physical and cognitive therapy intervention versus standard care neither reduced nor increased in-hospital mortality, (RR 0.94, 95% CI 0.40 to 2.20, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of delirium- and coma-free days, (MD -2.8, 95% CI -10.1 to 4.6, I2; = 0; 1 study, 65 participants; very low-quality evidence); the number of ventilator-free days (within the first 28/30 days) was median 27.4 (IQR 0 to 29.2) and 25 (IQR 0 to 28.9); 1 study, 65 participants; very low-quality evidence, length of ICU stay, (MD 1.23, 95% CI -0.68 to 3.14, I2; = 0; 1 study, 65 participants; very low-quality evidence); cognitive impairment measured by the MMSE: Mini-Mental State Examination with higher scores indicating better function, (MD 0.97, 95% CI -0.19 to 2.13, I2; = 0; 1 study, 30 participants; very low-quality evidence); or measured by the Dysexecutive questionnaire (DEX) with lower scores indicating better function (MD -8.76, 95% CI -19.06 to 1.54, I2; = 0; 1 study, 30 participants; very low-quality evidence). One patient experienced acute back pain accompanied by hypotensive urgency during physical therapy. Authors’ conclusions: There is probably little or no difference between haloperidol and placebo for preventing ICU delirium but further studies are needed to increase our confidence in the findings. There is insufficient evidence to determine the effects of physical and cognitive intervention on delirium. The effects of other pharmacological interventions, sedation, environmental, and preventive nursing interventions are unclear and warrant further investigation in large multicentre studies. Five studies are awaiting classification and we identified 15 ongoing studies, evaluating pharmacological interventions, sedation regimens, physical and occupational therapy combined or separately, and environmental interventions, that may alter the conclusions of the review in future.
- PMID
- Keywords
ISRCTN83567338
NCT00095251
NCT00466492
NCT00675363
NCT00824239
NCT01270269
NCT01274819
NCT01739933
NCT01785290
NCT01791296
NCT0196768
NCT01983800
NCT02245256
NCT02548923
NCT02612948
NCT02615340
NCT02932358
NCT03002701
NCT03095443
NCT03125252
NCT03172897
NCT03215745
dexmedetomidine
haloperidol
lorazepam
placebo
adult
APACHE
artificial ventilation
bradycardia
cognitive defect
cognitive therapy
coma
critically ill patient
delirium
environmental intervention
health care cost
hospital mortality
human
intensive care unit
intention to treat analysis
intervention study
length of stay
nursing intervention
outcome assessment
physiotherapy
priority journal
randomized controlled trial (topic)
review
sedation
seizure
sensitivity analysis
treatment duration
ventilator weaning
- Page(s)
- Volume
- 2018
- Issue
- 11
Title | Authors | Journal | Year | Keywords |
---|---|---|---|---|
Mobilizing older adults: A multi-site, exploratory and observational study on patients enrolled in the Hospital Elder Life Program (HELP). | Babine, R. L. Hyrkas, K. E. McKenzie, C. G. Wierman, H. R. | Geriatr Nurs | 2018 |
Older adults |
Validation of the Stanford Proxy Test for Delirium (S-PTD) among critical and noncritical patients. | Alosaimi, F. D. Alghamdi, A. Alsuhaibani, R. Alhammad, G. Albatili, A. Albatly, L. Althomali, B. Aljamaan, F. Maldonado, J. R. | J Psychosom Res | 2018 |
Delirium |
Impact of an Antipsychotic Discontinuation Bundle During Transitions of Care in Critically Ill Patients. | D’Angelo, R. G. Rincavage, M. Tata, A. L. Millstein, L. S. Gulati, M. S. Flurie, R. W. Gonzales, J. P. | J Intensive Care Med | 2019 |
urinary catheter |
Living at home after emergency hospital admission: Prospective cohort study in older adults with and without cognitive spectrum disorder. | Burton, J. K. Guthrie, B. Hapca, S. M. Cvoro, V. Donnan, P. T. Reynish, E. L. | BMC Medicine | 2018 |
aged |
The Association Between C-Reactive Protein and Postoperative Delirium Differs by Catechol-O-Methyltransferase Genotype. | Vasunilashorn, S. M. Ngo, L. H. Jones, R. N. Inouye, S. K. Hall, K. T. Gallagher, J. Dillon, S. T. Xie, Z. Libermann, T. A. Marcantonio, E. R. | American Journal of Geriatric Psychiatry | 2019 |
acute phase protein |
Risk factors associated with acute in-hospital delirium for patients diagnosed with a hip fracture in the emergency department. | Thompson, C. Brienza, V. J. M. Sandre, A. Caine, S. Borgundvaag, B. McLeod, S. | Canadian Journal of Emergency Medicine | 2018 |
codeine |
A Comparison of Early, Late, and No Treatment of Intensive Care Unit Delirium With Antipsychotics: A Retrospective Cohort Study. | Thom, R. P. Bui, M. P. Rosner, B. Teslyar, P. Levy-Carrick, N. C. Klompas, M. | The Primary Care Companion for CNS Disorders | 2018 |
neuroleptic agent |
Postoperative Pain Management Strategies and Delirium After Transapical Aortic Valve Replacement: A Randomized Controlled Trial. | Strike, E. Arklina, B. Stradins, P. Cusimano, R. J. Osten, M. Horlick, E. Styra, R. Poonawala, H. Carroll, J. Djaiani, G. | Journal of Cardiothoracic and Vascular Anesthesia | 2018 |
adult |
Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium: The STRIDE Randomized Clinical Trial. | Sieber, F. E. Neufeld, K. J. Gottschalk, A. Bigelow, G. E. Oh, E. S. Rosenberg, P. B. Mears, S. C. Stewart, K. J. Ouanes, J. P. P. Jaberi, M. Hasenboehler, E. A. Li, T. Wang, N. Y. | JAMA Surg | 2018 |
local anesthetic agent |
Incidence of Delirium in Critically Ill Cancer Patients. | Sánchez-Hurtado, L. A. Hernández-Sánchez, N. Del Moral-Armengol, M. Guevara-García, H. García-Guillén, F. J. Herrera-Gómez, Á Ñamendys-Silva, S. A. | Pain Research & Management | 2018 |
adult |
Dispersion in Scores on the Richmond Agitation and Sedation Scale as a Measure of Delirium in Patients with Subdural Hematomas. | Robinson, D. Thompson, S. Bauerschmidt, A. Melmed, K. Couch, C. Park, S. Agarwal, S. Roh, D. Connolly, E. S. Claassen, J. | Neurocritical Care | 2018 |
adult |
Underdiagnosis of delirium in the elderly in acute care hospital settings: lessons not learned. | Ritter, S. R. F. Cardoso, A. F. Lins, M. M. P. Zoccoli, T. L. V. Freitas, M. P. D. Camargos, E. F. | Psychogeriatrics | 2018 |
aged |
Risk Factors and Hospital Mortality in Surgical and Non-surgical Patients with Delirium. | Restrepo, D. Duque, M. Montoya, L. Berrouet, M. C. Rojas, M. Lopera, G. Giraldo, K. | Revista Colombiana de Psiquiatria | 2018 |
cholinergic receptor blocking agent |
Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults. | Pun, B. T. Balas, M. C. Barnes-Daly, M. A. Thompson, J. L. Aldrich, J. M. Barr, J. Byrum, D. Carson, S. S. Devlin, J. W. Engel, H. J. Esbrook, C. L. Hargett, K. D. Harmon, L. Hielsberg, C. Jackson, J. C. Kelly, T. L. Kumar, V. Millner, L. Morse, A. Perme, | Crit Care Med | 2019 |
adult |
Effects of Perioperative Dexmedetomidine on Postoperative Mortality and Morbidity: A Systematic Review and Meta-analysis | Peng, K. Ji, F. H. Liu, H. Y. Zhang, J. Chen, Q. C. Jiang, Y. H. | Clinical Therapeutics | 2018 |
adult |
Relation Between Delirium and Anticholinergic Drug Burden in a Cohort of Hospitalized Older Patients: An Observational Study. | Pasina, L. Colzani, L. Cortesi, L. Tettamanti, M. Zambon, A. Nobili, A. Mazzone, A. Mazzola, P. Annoni, G. Bellelli, G. | Drugs Aging | 2018 |
adverse event |
Neopterin and mini-mental state examination scores, two independent risk factors for postoperative delirium in elderly patients with open abdominal surgery. | Miao, S. Shen, P. Zhang, Q. Wang, H. Shen, J. Wang, G. Lv, D. | Journal of Cancer Research and Therapeutics | 2018 |
C reactive protein |
Reliability and accuracy of delirium assessments among investigators at multiple international centres. | Maybrier, H. R. Mickle, A. M. Escallier, K. E. Lin, N. Schmitt, E. M. Upadhyayula, R. T. Wildes, T. S. Mashour, G. A. Palihnich, K. Inouye, S. K. Avidan, M. S. | BMJ Open | 2018 |
NCT01690988 |
Does the melatonin receptor 1B gene polymorphism have a role in postoperative delirium? | Mahanna-Gabrielli, E. Miano, T. A. Augoustides, J. G. Kim, C. Bavaria, J. E. Andrew Kofke, W. | PLoS ONE | 2018 |
adult |
Volatile anaesthetics and postoperative delirium in older surgical patients—A secondary analysis of prospective cohort studies | Kinjo, S. Lim, E. Magsaysay, M. V. Sands, L. P. Leung, J. M. | Acta Anaesthesiol Scand | 2019 |
desflurane |
Addition of Suvorexant to Ramelteon Therapy for Improved Sleep Quality with Reduced Delirium Risk in Acute Stroke Patients. | Kawada, K. Ohta, T. Tanaka, K. Miyamura, M. Tanaka, S. | Journal of Stroke and Cerebrovascular Diseases | 2019 |
phosphorus 33 |
Age-dependent morbidity and mortality outcomes after surgical aortic valve replacement. | Hussain, A. I. Auensen, A. Brunborg, C. Beitnes, J. O. Gullestad, L. Pettersen, K. I. | Interactive cardiovascular and thoracic surgery | 2018 |
NCT01794832 |
Interventions for preventing intensive care unit delirium in adults. | Herling, S. F. Greve, I. E. Vasilevskis, E. E. Egerod, I. Bekker Mortensen, C. Møller, A. M. Svenningsen, H. Thomsen, T. | Cochrane Database of Systematic Reviews | 2018 |
ISRCTN83567338 |
Mortality in people with dementia, delirium, and unspecified cognitive impairment in the general hospital: Prospective cohort study of 6,724 patients with 2 years follow-up. | Hapca, S. Guthrie, B. Cvoro, V. Bu, F. Rutherford, A. C. Reynish, E. Donnan, P. T. | Clinical Epidemiology | 2018 |
aged |
Neurofilament Light in the Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium. | Halaas, N. B. Blennow, K. Idland, A. V. Wyller, T. B. Ræder, J. Frihagen, F. Staff, A. C. Zetterberg, H. Watne, L. O. | Dementia and Geriatric Cognitive Disorders | 2018 |
aged |
Investigating speech and language impairments in delirium: A preliminary case-control study. | Green, S. Reivonen, S. Rutter, L. M. Nouzova, E. Duncan, N. Clarke, C. MacLullich, A. M. J. Tieges, Z. | PLoS One | 2018 |
aged |
Elevated serum S-100β in patients with septic shock is associated with delirium. | Erikson, K. Ala-Kokko, T. I. Koskenkari, J. Liisanantti, J. H. Kamakura, R. Herzig, K. H. Syrjälä, H. | Acta Anaesthesiol Scand | 2019 |
interleukin 6 |
A prospective, observational study of cerebrovascular autoregulation and its association with delirium following cardiac surgery. | Chan, B. Aneman, A. | Anaesthesia | 2019 |
FORESIGHT Elite |
Dynamic cerebral autoregulation: A marker of post-operative delirium? | Caldas, J. R. Panerai, R. B. Bor-Seng-Shu, E. Ferreira, G. S. R. Camara, L. Passos, R. H. de-Lima-Oliveira, M. Galas, F. R. B. G. Almeida, J. P. Nogueira, R. C. Mian, N. Gaiotto, F. A. Robinson, T. G. Hajjar, L. A. | Clinical Neurophysiology | 2018 |
NCT02143544 |
The Golden Angels: Effects of trained volunteers on specialling and readmission rates for people with dementia and delirium in rural hospitals. | Blair, A. Anderson, K. Bateman, C. | International Psychogeriatrics | 2018 |
hearing aid |
The effectiveness of non-pharmacological interventions in reducing the incidence and duration of delirium in critically ill patients: a systematic review and meta-analysis. | Bannon, L. McGaughey, J. Verghis, R. Clarke, M. McAuley, D. F. Blackwood, B. | Intensive Care Medicine | 2018 |
adult |
Blood Thiamine Level and Cognitive Function in Older Hospitalized Patients. | Pourhassan, M. Angersbach, B. Lueg, G. Klimek, C. N. Wirth, R. | J Geriatr Psychiatry Neurol | 2018 |
delirium |
Low doses of ketamine reduce delirium but not opiate consumption in mechanically ventilated and sedated ICU patients: A randomised double-blind control trial. | Perbet, S. Verdonk, F. Godet, T. Jabaudon, M. Chartier, C. Cayot, S. Guerin, R. Morand, D. Bazin, J. E. Futier, E. Pereira, B. Constantin, J. M. | Anaesth Crit Care Pain Med | 2018 |
Consumption of opiates |
CSF sodium at toxic levels precedes delirium in hip fracture patients. | Hassel, B. Mariussen, E. Idland, A. V. Dahl, G. T. Raeder, J. Frihagen, F. Berg, J. P. Chaudhry, F. A. Wyller, T. B. Watne, L. O. | Neurotoxicology | 2018 |
Cerebrospinal fluid |
Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation. | Zamami, Y. Kouno, Y. Niimura, T. Chuma, M. Imai, T. Mitsui, M. Koyama, T. Kayano, M. Okada, N. Hamano, H. Goda, M. Imanishi, M. Takechi, K. Horinouchi, Y. Kondo, Y. Yanagawa, H. Kitamura, Y. Sendo, T. Ujike, Y. Ishizawa, K. | Pharmazie | 2018 | |
Prevalence and risk factors of delirium and subsyndromal delirium in Chinese older adults. | Yam, K. K. Shea, Y. F. Chan, T. C. Chiu, K. C. Luk, J. K. Chu, L. W. Chan, F. H. | Geriatrics & Gerontology International | 2018 |
Chinese |
Home-based Cognitive Prehabilitation in Older Surgical Patients: A Feasibility Study. | Vlisides, P. E. Das, A. R. Thompson, A. M. Kunkler, B. Zierau, M. Cantley, M. J. McKinney, A. M. Giordani, B. | J Neurosurg Anesthesiol | 2018 | |
Meta-analysis of Prevalence and Risk Factors for Delirium After Transcatheter Aortic Valve Implantation. | Tilley, E. Psaltis, P. J. Loetscher, T. Davis, D. H. Harrison, S. L. Kim, S. Keage, H. A. D. | Am J Cardiol | 2018 | |
Development and feasibility of a smartphone-based test for the objective detection and monitoring of attention impairments in delirium in the ICU. | Tang, E. Laverty, M. Weir, A. Wilson, E. S. Walsh, T. S. Allerhand, M. Parks, S. MacLullich, A. M. J. Tieges, Z. | J Crit Care | 2018 |
Arousal |
Retrospective Analysis of Perioperative Variables Associated With Postoperative Delirium and Other Adverse Outcomes in Older Patients After Spine Surgery. | Susano, M. J. Scheetz, S. D. Grasfield, R. H. Cheung, D. Xu, X. Kang, J. D. Smith, T. R. Lu, Y. Groff, M. W. Chi, J. H. Crosby, G. Culley, D. J. | J Neurosurg Anesthesiol | 2018 | |
Delirium detection by a novel bispectral electroencephalography device in general hospital. | Shinozaki, G. Chan, A. C. Sparr, N. A. Zarei, K. Gaul, L. N. Heinzman, J. T. Robles, J. Yuki, K. Chronis, T. J. Ando, T. Wong, T. Sabbagh, S. Weckmann, M. T. Lee, S. Yamada, T. Karam, M. D. Noiseux, N. O. Shinozaki, E. Cromwell, J. W. | Psychiatry Clin Neurosci | 2018 |
Aged |
Incremental cost and length of stay associated with postprocedure delirium in transcatheter and surgical aortic valve replacement patients in the United States. | Potter, B. J. Thompson, C. Green, P. Clancy, S. | Catheterization and Cardiovascular Interventions | 2018 |
aortic |
Effect of regional versus general anaesthesia on postoperative delirium in elderly patients undergoing surgery for hip fracture: a systematic review. | Patel, V. Champaneria, R. Dretzke, J. Yeung, J. | BMJ Open | 2018 |
general anaesthesia |
The Role of Perioperative Statin Use in the Prevention of Delirium After Total Knee Replacement Under Spinal Anesthesia. | Oh, T. K. Park, H. Y. Shin, H. J. Jeon, Y. T. Do, S. H. Hwang, J. W. | J Arthroplasty | 2018 |
analgesics |
Observational Study Examining the Association of Baseline Frailty and Postcardiac Surgery Delirium and Cognitive Change. | Nomura, Y. Nakano, M. Bush, B. Tian, J. Yamaguchi, A. Walston, J. Hasan, R. Zehr, K. Mandal, K. LaFlam, A. Neufeld, K. J. Kamath, V. Hogue, C. W. Brown, C. H. th | Anesth Analg | 2018 | |
CAM-ICU may not be the optimal screening tool for early delirium screening in older emergency department patients: a prospective cohort study. | Lucke, J. A. De Gelder, J. Blomaard, L. C. Fogteloo, A. J. Alsma, J. Schuit, S. C. E. Brink, A. De Groot, B. Blauw, G. J. Mooijaart, S. P. | Eur J Emerg Med | 2018 | |
Relation of postoperative serum S100A12 levels to delirium and cognitive dysfunction occurring after hip fracture surgery in elderly patients. | Li, Q. H. Yu, L. Yu, Z. W. Fan, X. L. Yao, W. X. Ji, C. Deng, F. Luo, X. Z. Sun, J. L. | Brain Behav | 2018 |
S100a12 |
A scoping review to map empirical evidence regarding key domains and questions in the clinical pathway of delirium in palliative care. | Lawlor, P. G. Rutkowski, N. A. MacDonald, A. R. Ansari, M. T. Sikora, L. Momoli, F. Kanji, S. Wright, D. K. Rosenberg, E. Hosie, A. Pereira, J. L. Meagher, D. Rice, J. Scott, J. Bush, S. H. | J Pain Symptom Manage | 2018 |
analytic framework |
Arousal changes and delirium in acute medically-ill male older patients with and without dementia: a prospective study during hospitalization. | Lagarto, L. Albuquerque, E. Loureiro, D. Vieira, F. Esteves, P. Neves, S. Teixeira-Verissimo, M. Cerejeira, J. | Aging Ment Health | 2018 |
Arousal |
Incidence and Prevalence of Delirium Subtypes in an Adult ICU: A Systematic Review and Meta-Analysis. | Krewulak, K. D. Stelfox, H. T. Leigh, J. P. Ely, E. W. Fiest, K. M. | Crit Care Med | 2018 | |
Association between death and loss of stage N2 sleep features among critically Ill patients with delirium. | Knauert, M. P. Gilmore, E. J. Murphy, T. E. Yaggi, H. K. Van Ness, P. H. Han, L. Hirsch, L. J. Pisani, M. A. | J Crit Care | 2018 |
Critical illness |
Preventing Postoperative Delirium After Major Noncardiac Thoracic Surgery-A Randomized Clinical Trial. | Khan, B. A. Perkins, A. J. Campbell, N. L. Gao, S. Khan, S. H. Wang, S. Fuchita, M. Weber, D. J. Zarzaur, B. L. Boustani, M. A. Kesler, K. | J Am Geriatr Soc | 2018 |
Icu |
Effect of nonpharmacological interventions for the prevention of delirium in the intensive care unit: A systematic review and meta-analysis. | Kang, J. Lee, M. Ko, H. Kim, S. Yun, S. Jeong, Y. Cho, Y. | J Crit Care | 2018 |
Delirium |
Assessment of Instruments for Measurement of Delirium Severity: A Systematic Review. | Jones, R. N. Cizginer, S. Pavlech, L. Albuquerque, A. Daiello, L. A. Dharmarajan, K. Gleason, L. J. Helfand, B. Massimo, L. Oh, E. Okereke, O. I. Tabloski, P. Rabin, L. A. Yue, J. Marcantonio, E. R. Fong, T. G. Hshieh, T. T. Metzger, E. D. Erickson, K. Sc | JAMA Intern Med | 2018 | |
Nurses' Recognition of Hospitalized Older Patients With Delirium and Cognitive Impairment Using the Delirium Observation Screening Scale: A Prospective Comparison Study. | Hasemann, W. Tolson, D. Godwin, J. Spirig, R. Frei, I. A. Kressig, R. W. | J Gerontol Nurs | 2018 | |
Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium. | Halaas, N. B. Blennow, K. Idland, A. V. Wyller, T. B. Raeder, J. Frihagen, F. Staff, A. C. Zetterberg, H. Watne, L. O. | Dement Geriatr Cogn Disord | 2018 |
*Blood and cerebrospinal fluid biomarker |
Delirium Subtypes and Associated Characteristics in Older Patients With Exacerbation of Chronic Conditions. | Gual, N. Inzitari, M. Carrizo, G. Calle, A. Udina, C. Yuste, A. Morandi, A. | Am J Geriatr Psychiatry | 2018 |
Delirium motor subtypes |
Antimicrobial exposure and the risk of delirium in critically ill patients. | Grahl, J. J. Stollings, J. L. Rakhit, S. Person, A. K. Wang, L. Thompson, J. L. Pandharipande, P. P. Ely, E. W. Patel, M. B. | Crit Care | 2018 |
*Antibiotics |
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness. | Girard, T. D. Exline, M. C. Carson, S. S. Hough, C. L. Rock, P. Gong, M. N. Douglas, I. S. Malhotra, A. Owens, R. L. Feinstein, D. J. Khan, B. Pisani, M. A. Hyzy, R. C. Schmidt, G. A. Schweickert, W. D. Hite, R. D. Bowton, D. L. Masica, A. L. Thompson, J. | N Engl J Med | 2018 | |
A Systematic Review and Meta-Analysis Examining the Impact of Sleep Disturbance on Postoperative Delirium. | Fadayomi, A. B. Ibala, R. Bilotta, F. Westover, M. B. Akeju, O. | Crit Care Med | 2018 | |
Pharmacologic Treatment of Intensive Care Unit Delirium and the Impact on Duration of Delirium, Length of Intensive Care Unit Stay, Length of Hospitalization, and 28-Day Mortality. | Daniels, L. M. Nelson, S. B. Frank, R. D. Park, J. G. | Mayo Clin Proc | 2018 | |
Incidence and clinical significance of postoperative delirium after brain tumor surgery. | Budenas, A. Tamasauskas, S. Sliauzys, A. Navickaite, I. Sidaraite, M. Pranckeviciene, A. Deltuva, V. P. Tamasauskas, A. Bunevicius, A. | Acta Neurochir (Wien) | 2018 |
Brain tumor |
Role of perceived stress in postoperative delirium: an investigation among elderly patients. | Banjongrewadee, M. Wongpakaran, N. Wongpakaran, T. Pipanmekaporn, T. Punjasawadwong, Y. Mueankwan, S. | Aging Ment Health | 2018 |
Perceived stress |
Predictors and Sequelae of Postoperative Delirium in Geriatric Hip Fracture Patients. | Arshi, A. Lai, W. C. Chen, J. B. Bukata, S. V. Stavrakis, A. I. Zeegen, E. N. | Geriatr Orthop Surg Rehabil | 2018 |
delirium |
Operative and anaesthetic factors influencing on delirium in the intensive care unit: An Analysis of electronic health records. | An, Y. S. Jin, Y. Jin, T. Hur, E. Y. Lee, S. M. | J Clin Nurs | 2018 |
delirium |
Effect of anticholinergic burden on treatment modification, delirium and mortality in newly diagnosed dementia patients starting a cholinesterase inhibitor: a population-based study. | Ah, Y. M. Suh, Y. Jun, K. Hwang, S. Lee, J. Y. | Basic Clin Pharmacol Toxicol | 2018 |
Alzheimer’s disease |
Postoperative Delirium in Individuals Undergoing Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis. | Abawi, M. Pagnesi, M. Agostoni, P. Chiarito, M. van Jaarsveld, R. C. van Dongen, C. S. Slooter, A. J. C. Colombo, A. Kooistra, N. H. M. Doevendans, Pafm Latib, A. Stella, P. R. | J Am Geriatr Soc | 2018 |
Tavr |
Effect of goal-directed fluid therapy on early cognitive function in elderly patients with spinal stenosis: A Case-Control Study. | Zhang, N. Liang, M. Zhang, D. D. Xiao, Y. R. Li, Y. Z. Gao, Y. G. Cai, H. D. Lin, X. Z. Lin, C. Z. Zeng, K. Wu, X. D. | Int J Surg | 2018 |
Elderly patients |
Rehospitalization following a stay in geriatric rehabilitation wards: rates and predictive factors. | Tardivel, M. Muller, F. Tortrat, D. Lechowski, L. Teillet, L. | Geriatr Psychol Neuropsychiatr Vieil | 2018 |
geriatric post-acute and rehabilitation care wards |
Elimination of Routine Benzodiazepine Administration for Nonprocedural Sedation in a Trauma Intensive Care Unit Is Feasible. | McGinn, K. Davis, S. N. Terrry, E. Simmons, J. Brevard, S. | Am Surg | 2018 |
Adult |
Can Chaotic Analysis of Electroencephalogram Aid the Diagnosis of Encephalopathy? | Jacob, J. E. Cherian, A. Gopakumar, K. Iype, T. Yohannan, D. G. Divya, K. P. | Neurology Research International | 2018 |
adult |
Hospital outcomes of older people with cognitive impairment: An integrative review. | Fogg, C. Griffiths, P. Meredith, P. Bridges, J. | Int J Geriatr Psychiatry | 2018 |
cognitive dysfunction |
Physostigmine is superior to non-antidote therapy in the management of antimuscarinic delirium: a prospective study from a regional poison center. | Boley, S. P. Olives, T. D. Bangh, S. A. Fahrner, S. Cole, J. B. | Clin Toxicol | 2018 |
Physostigmine |
Cholinesterase inhibitors for the treatment of delirium in non-ICU settings. | Yu, A. Wu, S. Zhang, Z. Dening, T. Zhao, S. Pinner, G. Xia, J. Yang, D. | Cochrane Database of Systematic Reviews | 2018 | |
Perioperative dexmedetomidine reduces delirium after cardiac surgery: A meta-analysis of randomized controlled trials | Wu, M. Liang, Y. Dai, Z. Wang, S. | J Clin Anesth | 2018 |
Cardiac surgery |
Diabetes and Glucose Dysregulation and Transition to Delirium in ICU Patients. | van Keulen, K. Knol, W. Belitser, S. V. van der Linden, P. D. Heerdink, E. R. Egberts, T. C. G. Slooter, A. J. C. | Crit Care Med | 2018 | |
Factors associated with delirium in critical patients in a health institution in Bucaramanga, Colombia. | Torres-Contreras, C. C. Paez-Esteban, A. N. Hinestrosa-Diaz Del Castillo, A. Rincon-Romero, M. K. Amaris-Vega, A. Martinez-Patino, J. P. | Enferm Intensiva | 2018 |
Delirium |
The effect of preoperative cognitive impairment and type of vascular surgery procedure on postoperative delirium with associated cost implications. | Styra, R. Larsen, E. Dimas, M. A. Baston, D. Elgie-Watson, J. Flockhart, L. Lindsay, T. F. | J Vasc Surg | 2018 |
Cognition |
Rate and risk factors for a hyperactivity delirium in patients with aneurysmal subarachnoid haemorrhage. | Sauvigny, T. Mohme, M. Grensemann, J. Duhrsen, L. Regelsberger, J. Kluge, S. Schmidt, N. O. Westphal, M. Czorlich, P. | Neurosurg Rev | 2018 |
Delirium |
Delirium in Postoperative Patients Admitted to the Intensive Care Unit. | Romanauski, T. R. Martin, E. E. Sprung, J. Martin, D. P. Schroeder, D. R. Weingarten, T. N. | Am Surg | 2018 |
Adult |
Degree of implementation of preventive strategies for post-ICU syndrome: Multi-centre, observational study in Spain. | Raurell-Torreda, M. Arias-Rivera, S. Marti, J. D. Frade-Mera, M. J. Zaragoza-Garcia, I. Gallart, E. Velasco-Sanz, T. R. San Jose-Arribas, A. Blazquez-Martinez, E. | Enferm Intensiva | 2018 |
Critical illness |
Surgical delay is a risk factor of delirium in hip fracture patients with mild-moderate cognitive impairment. | Pioli, G. Bendini, C. Giusti, A. Pignedoli, P. Cappa, M. Iotti, E. Ferri, M. A. Bergonzini, E. Sabetta, E. | Aging Clin Exp Res | 2018 |
Delirium |
Predictors of Delirium Development in Older Medical Inpatients: Readily Identifiable Factors at Admission. | O’Regan, Niamh A. Fitzgerald, James Adamis, Dimitrios Molloy, David William Meagher, David Timmons, Suzanne Montero-Odasso, Manuel | Journal of Alzheimer's Disease | 2018 | |
Processed Electroencephalogram Monitoring and Postoperative Delirium: A Systematic Review and Meta-analysis. | MacKenzie, K. K. Britt-Spells, A. M. Sands, L. P. Leung, J. M. | Anesthesiology | 2018 | |
The influence of oxygen delivery during cardiopulmonary bypass on the incidence of delirium in CABG patients; a retrospective study | Leenders, J. Overdevest, E. van Straten, B. Golab, H. | Perfusion | 2018 |
Cabg |
Safety of brotizolam in hospitalized patients. | Lavon, O. Bejel, S. | European Journal of Clinical Pharmacology | 2018 |
benzodiazepine derivative |
Early delirium after cardiac surgery: An analysis of incidence and risk factors in elderly (≥65 years) and very elderly (≥80 years) patients. | Kotfis, K. Szylińska, A. Listewnik, M. Strzelbicka, M. Brykczyński, M. Rotter, I. Żukowski, M. | Clinical Interventions in Aging | 2018 |
creatinine |
ICU delirium - a diagnostic and therapeutic challenge in the intensive care unit. | Kotfis, K. Marra, A. Ely, E. W. | Anaesthesiol Intensive Ther | 2018 |
Cam-icu |
Melatonin and sleep in preventing hospitalized delirium: A randomized clinical trial. | Jaiswal, S. J. McCarthy, T. J. Wineinger, N. E. Kang, D. Y. Song, J. Garcia, S. van Niekerk, C. J. Lu, C. Y. Loeks, M. Owens, R. L. | Am J Med | 2018 |
Delirium |
Intraoperative ketamine administration to prevent delirium or postoperative cognitive dysfunction: A systematic review and meta-analysis. | Hovaguimian, F. Tschopp, C. Beck-Schimmer, B. Puhan, M. | Acta Anaesthesiol Scand | 2018 |
cognitive dysfunction |
The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses. | Hov, K. R. Neerland, B. E. Andersen, A. M. Undseth, O. Wyller, V. B. MacLullich, A. M. J. Skovlund, E. Qvigstad, E. Wyller, T. B. | BMC Pharmacol Toxicol | 2018 |
Clonidine |
Delirium's Arousal Subtypes and Their Relationship with 6-Month Functional Status and Cognition. | Han, J. H. Hayhurst, C. J. Chandrasekhar, R. Hughes, C. G. Vasilevskis, E. E. Wilson, J. E. Schnelle, J. F. Dittus, R. S. Ely, E. W. | Psychosomatics | 2018 |
aged |
Intraoperative electroencephalogram suppression at lower volatile anaesthetic concentrations predicts postoperative delirium occurring in the intensive care unit. | Fritz, B. A. Maybrier, H. R. Avidan, M. S. | British Journal of Anaesthesia | 2018 |
NCT02032030 |
Efficacy of perioperative dexmedetomidine on postoperative delirium: systematic review and meta-analysis with trial sequential analysis of randomised controlled trials. | Duan, X. Coburn, M. Rossaint, R. Sanders, R. D. Waesberghe, J. V. Kowark, A. | British Journal of Anaesthesia | 2018 |
adult |
Long-term sequelae of acute respiratory distress syndrome caused by severe community-acquired pneumonia: Delirium-associated cognitive impairment and post-traumatic stress disorder. | Denke, C. Balzer, F. Menk, M. Szur, S. Brosinsky, G. Tafelski, S. Wernecke, K. D. Deja, M. | J Int Med Res | 2018 |
Community-acquired pneumonia |
A Performing Arts Intervention Improves Cognitive Dysfunction in 50 Hospitalized Older Adults. | Danila, M. I. Melnick, J. A. Mudano, A. Flood, K. Booth, K. Kirklin, K. Saag, K. G. | Innov Aging | 2018 |
Alternative and complementary medicine/care/therapy |
Nursing perspectives on the confusion assessment method: a qualitative focus group study. | Wong, E. K. Lee, J. Y. Surendran, A. S. Nair, K. Della Maestra, N. Migliarini, M. St Onge, J. A. Patterson, C. J. | Age Ageing | 2018 | |
Detection and management of hyperactive and hypoactive delirium in older patients during hospitalization: a retrospective cohort study evaluating daily practice. | van Velthuijsen, E. L. Zwakhalen, S. M. G. Mulder, W. J. Verhey, F. R. J. Kempen, Gijm | Int J Geriatr Psychiatry | 2018 |
care as usual |
Glucose variability during delirium in diabetic and non-diabetic intensive care unit patients: A prospective cohort study. | van Keulen, K. Knol, W. Belitser, S. V. Zaal, I. J. van der Linden, P. D. Heerdink, E. R. Egberts, T. C. G. Slooter, A. J. C. | PLoS One | 2018 | |
Evaluating the use of dexmedetomidine for the reduction of delirium: An integrative review. | Pavone, K. J. Cacchione, P. Z. Polomano, R. C. Winner, L. Compton, P. | Heart Lung | 2018 |
Delirium |