What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Common molecular and pathophysiological underpinnings of delirium and Alzheimer's disease: molecular signatures and therapeutic indications
- Authors
- Mosharaf, M. P. Alam, K. Gow, J. Mahumud, R. A. Mollah, M. N. H.
- Year
- 2024
- Journal
- BMC Geriatr
- Abstract
BACKGROUND: Delirium and Alzheimer’s disease (AD) are common causes of cognitive dysfunction among older adults. These neurodegenerative diseases share a common and complex relationship, and can occur individually or concurrently, increasing the chance of permanent mental dysfunction. However, the common molecular pathophysiology, key proteomic biomarkers, and functional pathways are largely unknown, whereby delirium is superimposed on AD and dementia. METHODS: We employed an integrated bioinformatics and system biology analysis approach to decipher such common key proteomic signatures, pathophysiological links between delirium and AD by analyzing the gene expression data of AD-affected human brain samples and comparing them with delirium-associated proteins. The present study identified the common drug target hub-proteins examining the protein-protein interaction (PPI) and gene regulatory network analysis. The functional enrichment and pathway analysis was conducted to reveal the common pathophysiological relationship. Finally, the molecular docking and dynamic simulation was used to computationally identify and validate the potential drug target and repurposable drugs for delirium and AD. RESULTS: We detected 99 shared differentially expressed genes (sDEGs) associated with AD and delirium. The sDEGs-set enrichment analysis detected the transmission across chemical synapses, neurodegeneration pathways, neuroinflammation and glutamatergic signaling pathway, oxidative stress, and BDNF signaling pathway as the most significant signaling pathways shared by delirium and AD. The disease-sDEGs interaction analysis highlighted the other disease risk factors with delirium and AD development and progression. Among the sDEGs of delirium and AD, the top 10 hub-proteins including ALB, APP, BDNF, CREB1, DLG4, GAD1, GAD2, GFAP, GRIN2B and GRIN2A were found by the PPI network analysis. Based on the maximum molecular docking binding affinities and molecular dynamic simulation (100 ns) results, the ALB and GAD2 were found as prominent drug target proteins when tacrine and donepezil were identified as potential drug candidates for delirium and AD. CONCLUSION: The study outlined the common key biomolecules and biological pathways shared by delirium and AD. The computationally reported potential drug molecules need a deeper investigation including clinical trials to validate their effectiveness. The outcomes from this study will help to understand the typical pathophysiological relationship between delirium and AD and flag future therapeutic development research for delirium.
- PMID
PMID: 39210294
PMICD: PMC11363673
- Keywords
Humans
*Alzheimer Disease/genetics/metabolism
*Delirium
Molecular Docking Simulation/methods
Aged
Computational Biology/methods
Protein Interaction Maps/physiology
Proteomics/methods
Biomarkers
Alzheimer’s disease
Common signaling pathways
Delirium
Drug repurposing
Essential drug targets
Molecular docking simulation
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Higher serum interieukin-6 is a strong postoperative predictor of delirium after isolated coronary artery bypass graft surgery | Sun, L. Ding, S. Feng, X. Wu, F. Su, P. Shen, Y. Zhao, H. Wu, Y. | Circulation | 2014 |
interleukin 6 |
| Deconstructing dementia and delirium hospital practice: using cultural historical activity theory to inform education approaches. | Teodorczuk A, Mukaetova-Ladinska E, Corbett S, Welfare M | Advances in health sciences education : theory and practice | 2015 |
Delirium, Dementia, England, Female, Focus Groups, Health Personnel, education, Hospitalization, Humans, Interviews as Topic, Male, Quality of Health Care |
| Assessment and Management of Delirium in Older Adults in the Emergency Department: Literature Review to Inform Development of a Novel Clinical Protocol. | Rosen T, Connors S, Clark S, Halpern A, Stern ME, DeWald J, Lachs MS, Flomenbaum N | Advanced emergency nursing journal | 2015 |
Aged, Clinical Protocols, Delirium, diagnosis, Education, Continuing, Emergency Service, Hospital, Humans |
| Gentle persuasive approaches: introducing an educational program on an orthopaedic unit for staff caring for patients with dementia and delirium. | Pizzacalla A, Montemuro M, Coker E, Martin LS, Gillies L, Robinson K, Pepper H, Benner J, Gusciora J | Orthopedic nursing | 2015 |
Critical Care Nursing, education, Curriculum, Delirium, nursing, Dementia, nursing, Humans, Medical Staff, Hospital, education, Nursing Staff, Hospital, education, Orthopedic Nursing, education, Persuasive Communication, Surgery Department, Hospital |
| The 3D-CAM provides a brief, easy to use, sensitive and specific delirium assessment tool for older hospitalised patients, both with and without dementia. | Pisani MA | Evidence-based mental health | 2015 |
Delirium, diagnosis, Female, Humans, Male, Neuropsychological Tests |
| The association of sleep quality, delirium, and sedation status with daily participation in physical therapy in the ICU. | Kamdar BB, Combs MP, Colantuoni E, King LM, Niessen T, Neufeld KJ, Collop NA, Needham DM | Critical care (London, England) | 2015 | |
| Disturbed Serotonergic Neurotransmission and Oxidative Stress in Elderly Patients with Delirium. | Egberts A, Fekkes D, Wijnbeld EH, van der Ploeg MA, van Saase JL, Ziere G, van der Cammen TJ, Mattace-Raso FU | Dementia and geriatric cognitive disorders extra | 2015 | |
| Factors that contribute to underrecognition of delirium by registered nurses in acute care settings: a scoping review of the literature to explain this phenomenon. | El Hussein M, Hirst S, Salyers V | Journal of clinical nursing | 2015 |
Aged, Critical Care Nursing, Delirium, diagnosis, Dementia, complications, Humans |
| Delirium as letting go: An ethnographic analysis of hospice care and family moral experience. | Wright DK, Brajtman S, Cragg B, Macdonald ME | Palliative medicine | 2015 | |
| Non-convulsive status epilepticus: a practical approach to diagnosis in confused older people. | Woodford HJ, George J, Jackson M | Postgraduate medical journal | 2015 | |
| Systemic Corticosteroids and Transition to Delirium in Critically Ill Patients. | Wolters AE, Veldhuijzen DS, Zaal IJ, Peelen LM, van Dijk D, Devlin JW, Slooter AJ | Critical care medicine | 2015 |
Adrenal Cortex Hormones, administration & dosage, Adult, Critical Illness, Delirium, chemically induced, Dose-Response Relationship, Drug, Female, Humans, Intensive Care Units, Logistic Models, Male, Middle Aged, Odds Ratio, Prospective Studies, Psychiatric Status Rating Scales |
| Postoperative delirium assessed by post anesthesia care unit staff utilizing the Nursing Delirium Screening Scale: a prospective observational study of 1000 patients in a single Swiss institution. | Winter A, Steurer MP, Dullenkopf A | BMC anesthesiology | 2015 |
Anesthesia, adverse effects, Anesthesia Recovery Period, Delirium, chemically induced, Feasibility Studies, Female, Humans, Incidence, Male, Middle Aged, Nursing Staff, Hospital, Postoperative Complications, chemically induced, Prospective Studies, Risk Factors, Switzerland |
| Lived experience of the intensive care unit for patients who experienced delirium. | Whitehorne K, Gaudine A, Meadus R, Solberg S | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2015 | |
| Preoperative protein profiles in cerebrospinal fluid in elderly hip fracture patients at risk for delirium: A proteomics and validation study. | Westhoff D, Witlox J, van Aalst C, Scholtens RM, de Rooij SE, van Munster BC, de Jonghe JF, Houdijk AP, Eikelenboom P, van Westerloo DJ, van de Beek D, van Gool WA, Koenderman L | BBA clinical | 2015 | |
| Variable lung protective mechanical ventilation decreases incidence of postoperative delirium and cognitive dysfunction during open abdominal surgery. | Wang R, Chen J, Wu G | International journal of clinical and experimental medicine | 2015 | |
| Risk factors contributing to postoperative delirium in geriatric patients postorthopedic surgery. | Wang J, Li Z, Yu Y, Li B, Shao G, Wang Q | Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists | 2015 | |
| Review of delirium in patients with Parkinson's disease. | Vardy ER, Teodorczuk A, Yarnall AJ | Journal of neurology | 2015 | |
| Delirium detection and improved delirium management in older patients hospitalized for hip fracture. | Todd KS, Barry J, Hoppough S, McConnell E | International journal of orthopaedic and trauma nursing | 2015 | |
| Prospective evaluation of inappropriate unable-to-assess CAM-ICU documentations of critically ill adult patients. | Terry KJ, Anger KE, Szumita PM | Journal of intensive care | 2015 | |
| Delirium in intensive care unit patients under noninvasive ventilation: a multinational survey. | Tanaka LM, Salluh JI, Dal-Pizzol F, Barreto BB, Zantieff R, Tobar E, Esquinas A, Quarantini Lde C, Gusmao-Flores D | Revista Brasileira de terapia intensiva | 2015 |
Attitude of Health Personnel, Critical Care, Delirium, diagnosis, Health Care Surveys, Humans, Intensive Care Units, Noninvasive Ventilation |
| Acetylcholinesterase Inhibitors for Delirium in Older Adults. | Tampi RR, Tampi DJ, Ghori AK | American journal of Alzheimer's disease and other dementias | 2016 | |
| Influence of Granulocyte-Macrophage Colony-Stimulating Factor or Influenza Vaccination on HLA-DR, Infection and Delirium Days in Immunosuppressed Surgical Patients: Double Blind, Randomised Controlled Trial. | Spies C, Luetz A, Lachmann G, Renius M, von Haefen C, Wernecke KD, Bahra M, Schiemann A, Paupers M, Meisel C | PloS one | 2015 | |
| Validation of the confusion assessment method in detecting postoperative delirium in cardiac surgery patients. | Smulter N, Lingehall HC, Gustafson Y, Olofsson B, Engström KG | American journal of critical care : an official publication, American Association of Critical-Care Nurses | 2015 | |
| Risk Factors for Delirium After Spinal Surgery: A Meta-Analysis. | Shi C, Yang C, Gao R, Yuan W | World neurosurgery | 2015 |
Aged, Aged, 80 and over, Delirium, epidemiology, Humans, Neurosurgical Procedures, adverse effects, Postoperative Complications, epidemiology, Risk Factors, Spine, surgery |
| Valproic Acid for Treatment of Hyperactive or Mixed Delirium: Rationale and Literature Review. | Sher Y, Miller Cramer AC, Ament A, Lolak S, Maldonado JR | Psychosomatics | 2015 | |
| The Successful Aging After Elective Surgery Study: Cohort Description and Data Quality Procedures. | Schmitt EM, Saczynski JS, Kosar CM, Jones RN, Alsop DC, Fong TG, Metzger E, Cooper Z, Marcantonio ER, Travison T, Inouye SK, | Journal of the American Geriatrics Society | 2015 | |
| The Montreal Cognitive Assessment: Creating a Crosswalk with the Mini-Mental State Examination. | Saczynski JS, Inouye SK, Guess J, Jones RN, Fong TG, Nemeth E, Hodara A, Ngo L, Marcantonio ER | Journal of the American Geriatrics Society | 2015 |
Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Cross-Sectional Studies, Delirium, diagnosis, Dementia, diagnosis, Female, Humans, Male, Mild Cognitive Impairment, diagnosis, Neuropsychological Tests |
| Delirium After Hip Fracture: Still a Problem. | Rudolph JL | Anesthesia and analgesia | 2015 |
Delirium, mortality, Female, Hip Fractures, mortality, Humans, Male, Postoperative Complications, mortality |
| The Bromhead Care Home Service: the impact of a service for care home residents with dementia on hospital admission and dying in preferred place of care. | Garden G, Green S, Pieniak S, Gladman J | Clinical medicine (London, England) | 2016 | |
| The Association Between Preoperative Frailty and Postoperative Delirium After Cardiac Surgery. | Brown CH, Max L, LaFlam A, Kirk L, Gross A, Arora R, Neufeld K, Hogue CW, Walston J, Pustavoitau A | Anesthesia and analgesia | 2016 | |
| Antipsychotic Drug Use and Screening for Delirium in Mechanically Ventilated Patients in Canadian Intensive Care Units: An Observational Study. | Thiboutot Z, Perreault MM, Williamson DR, Rose L, Mehta S, Guenette MD, Cook D, Burry L | The Canadian journal of hospital pharmacy | 2016 | |
| Abnormal Mini-Cog Is Associated with Higher Risk of Complications and Delirium in Geriatric Patients with Fracture. | Heng M, Eagen CE, Javedan H, Kodela J, Weaver MJ, Harris MB | The Journal of bone and joint surgery. American volume | 2016 | |
| DELirium Prediction Based on Hospital Information (Delphi) in General Surgery Patients. | Kim MY, Park UJ, Kim HT, Cho WH | Medicine | 2016 | |
| Serum Anticholinergic Activity and Cognitive and Functional Adverse Outcomes in Older People: A Systematic Review and Meta-Analysis of the Literature. | Salahudeen MS, Chyou TY, Nishtala PS | PloS one | 2016 | |
| Impact of length of red blood cells transfusion on postoperative delirium in elderly patients undergoing hip fracture surgery: A cohort study. | Zhang ZY, Gao DP, Yang JJ, Sun XR, Zhang H, Hu J, Fang ZY, Yang JJ, Ji MH | Injury | 2016 | |
| Nursing intervention versus usual care to improve delirium among home-dwelling older adults receiving homecare after hospitalization: feasibility and acceptability of a Randomized Controlled Trail. | Verloo H, Goulet C, Morin D, von Gunten A | BMC nursing | 2016 | |
| Use of medications that antagonize mediators of inflammatory responses may reduce the risk of delirium in older adults: a nested case-control study. | Cole MG, McCusker J, Wilchesky M, Voyer P, Monette J, Champoux N, Vu M, Ciampi A, Belzile E | International journal of geriatric psychiatry | 2016 | |
| Frequency of full, partial and no recovery from subsyndromal deliriumin older hospital inpatients. | Cole MG, Bailey R, Bonnycastle M, McCusker J, Fung S, Ciampi A, Belzile E | International journal of geriatric psychiatry | 2016 | |
| Preventing ICU Subsyndromal Delirium Conversion to Delirium With Low-Dose IV Haloperidol: A Double-Blind, Placebo-Controlled Pilot Study. | Al-Qadheeb NS, Skrobik Y, Schumaker G, Pacheco MN, Roberts RJ, Ruthazer RR, Devlin JW | Critical care medicine | 2016 | |
| Postoperative plasma 8-iso-prostaglandin F2α levels are associated with delirium and cognitive dysfunction in elderly patients after hip fracture surgery. | Zheng YB, Ruan GM, Fu JX, Su ZL, Cheng P, Lu JZ | Clinica chimica acta; international journal of clinical chemistry | 2016 | |
| Profiles of delirium and the clinical outcomes of patients who underwent coronary artery bypass grafting: a prospective study from China. | Zhang W, Hu W, Shen M, Ye X, Huang Y, Sun Y | Journal of clinical nursing | 2016 |
Adult, Aged, Aged, 80 and over, China, Coronary Artery Bypass, adverse effects, Coronary Artery Disease, psychology, Delirium, diagnosis, Female, Humans, Length of Stay, Male, Middle Aged, Outcome Assessment (Health Care), Prospective Studies |
| Risk factors for postoperative delirium following hip fracture repair in elderly patients: a systematic review and meta-analysis. | Yang Y, Zhao X, Dong T, Yang Z, Zhang Q, Zhang Y | Aging clinical and experimental research | 2017 | |
| RADAR: A Measure of the Sixth Vital Sign? | Voyer P, Champoux N, Desrosiers J, Landreville P, McCusker J, Monette J, Savoie M, Carmichael PH, Richard H, Richard S | Clinical nursing research | 2016 | |
| Association between frailty and delirium in older adult patients discharged from hospital. | Verloo H, Goulet C, Morin D, von Gunten A | Clinical interventions in aging | 2016 | |
| Psychometric properties and feasibility of instruments for the detection of delirium in older hospitalized patients: a systematic review. | van Velthuijsen EL, Zwakhalen SM, Warnier RM, Mulder WJ, Verhey FR, Kempen GI | International journal of geriatric psychiatry | 2016 | |
| The patient's perception of a delirium: A qualitative research in a Belgian intensive care unit. | Van Rompaey B, Van Hoof A, van Bogaert P, Timmermans O, Dilles T | Intensive & critical care nursing : the official journal of the British Association of Critical Care Nurses | 2016 | |
| Biomarkers of Delirium in a Low-Risk Community-Acquired Pneumonia-Induced Sepsis. | Tomasi CD, Vuolo F, Generoso J, Soares M, Barichello T, Quevedo J, Ritter C, Dal-Pizzol F | Molecular neurobiology | 2016 | |
| How to advance prediction of postoperative delirium? A secondary analysis comparing three methods for very early assessment of elderly patients after surgery and early prediction of delirium. | Stukenberg S, Franck M, Spies CD, Neuner B, Myers I, Radtke FM | Minerva anestesiologica | 2016 | |
| A Flipped Classroom Approach to Improving the Quality of Delirium Care Using an Interprofessional Train-the-Trainer Program. | Sockalingam S, James SL, Sinyi R, Carroll A, Laidlaw J, Yanofsky R, Sheehan K | The Journal of continuing education in the health professions | 2016 | |
| Reduced Cerebral Perfusion Pressure during Lung Transplant Surgery Is Associated with Risk, Duration, and Severity of Postoperative Delirium. | Smith PJ, Blumenthal JA, Hoffman BM, Rivelli SK, Palmer SM, Davis RD, Mathew JP | Annals of the American Thoracic Society | 2016 | |
| Depressive Symptoms and Risk of Postoperative Delirium. | Smith PJ, Attix DK, Weldon BC, Monk TG | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2016 | |
| Dynamic light application therapy to reduce the incidence and duration of delirium in intensive-care patients: a randomised controlled trial. | Simons KS, Laheij RJ, van den Boogaard M, Moviat MA, Paling AJ, Polderman FN, Rozendaal FW, Salet GA, van der Hoeven JG, Pickkers P, de Jager CP | The Lancet. Respiratory medicine | 2016 | |
| Interventions for preventing delirium in hospitalised non-ICU patients. | Siddiqi N, Harrison JK, Clegg A, Teale EA, Young J, Taylor J, Simpkins SA | The Cochrane database of systematic reviews | 2016 | |
| Validation of the Sour Seven Questionnaire for screening delirium in hospitalized seniors by informal caregivers and untrained nurses. | Shulman RW, Kalra S, Jiang JZ | BMC geriatrics | 2016 |
Aged, Aged, 80 and over, Caregivers, psychology, Delirium, diagnosis, Family, psychology, Female, Geriatric Assessment, methods, Hospitalization, Humans, Male, Mass Screening, methods, Nurse’s Role, psychology, Pilot Projects, Surveys and Questionnaires, standards |
| Efficacy and safety of haloperidol for in-hospital delirium prevention and treatment: A systematic review of current evidence. | Schrijver EJ, de Graaf K, de Vries OJ, Maier AB, Nanayakkara PW | European journal of internal medicine | 2016 | |
| Systematic review and meta-analysis of risk factors for postoperative delirium among older patients undergoing gastrointestinal surgery. | Scholz AF, Oldroyd C, McCarthy K, Quinn TJ, Hewitt J | The British journal of surgery | 2016 | |
| Validation of a Delirium Risk Assessment Using Electronic Medical Record Information. | Rudolph JL, Doherty K, Kelly B, Driver JA, Archambault E | Journal of the American Medical Directors Association | 2016 | |
| The implementation of a nonpharmacologic protocol to prevent intensive care delirium. | Rivosecchi RM, Kane-Gill SL, Svec S, Campbell S, Smithburger PL | Journal of critical care | 2016 | |
| Delirium superimposed on dementia: a survey of delirium specialists shows a lack of consensus in clinical practice and research studies. | Richardson S, Teodorczuk A, Bellelli G, Davis DH, Neufeld KJ, Kamholz BA, Trabucchi M, MacLullich AM, Morandi A | International psychogeriatrics / IPA | 2016 | |
| Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial. | Reade MC, Eastwood GM, Bellomo R, Bailey M, Bersten A, Cheung B, Davies A, Delaney A, Ghosh A, van Haren F, Harley N, Knight D, McGuiness S, Mulder J, O'Donoghue S, Simpson N, Young P, , | JAMA | 2016 |
Aged, Australia, Delirium, complications, Dexmedetomidine, administration & dosage, Double-Blind Method, Female, Humans, Hypnotics and Sedatives, administration & dosage, Male, Middle Aged, New Zealand, Proportional Hazards Models, Psychomotor Agitation, drug therapy, Respiration, Artificial, statistics & numerical data, Time Factors, Treatment Outcome, Ventilator Weaning, contraindications |
| Functional interrelationship of brain aging and delirium. | Rapazzini P | Aging clinical and experimental research | 2016 | |
| Delirium risk stratification in consecutive unselected admissions to acute medicine: validation of externally derived risk scores. | Pendlebury ST, Lovett N, Smith SC, Cornish E, Mehta Z, Rothwell PM | Age and ageing | 2016 | |
| A Family-Focused Delirium Educational Initiative With Practice and Research Implications. | Paulson CM, Monroe T, McDougall GJ, Fick DM | Gerontology & geriatrics education | 2016 | |
| How do doctors and nurses manage delirium in intensive care units? A qualitative study using focus groups. | Palacios-Ceña D, Cachón-Pérez JM, Martínez-Piedrola R, Gueita-Rodriguez J, Perez-de-Heredia M, Fernández-de-Las-Peñas C | BMJ open | 2016 | |
| The role of anesthesia in the prevention of postoperative delirium: a systematic review. | Orena EF, King AB, Hughes CG | Minerva anestesiologica | 2016 | |
| Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery in the Sugammadex Era: A Retrospective Study. | Oh CS, Rhee KY, Yoon TG, Woo NS, Hong SW, Kim SH | BioMed research international | 2016 | |
| High prolactin levels are associated with more delirium in septic patients. | Nguyen DN, Huyghens L, Schiettecatte J, Smitz J, Vincent JL | Journal of critical care | 2016 | |
| Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta-Analysis. | Neufeld KJ, Yue J, Robinson TN, Inouye SK, Needham DM | Journal of the American Geriatrics Society | 2016 | |
| Depressive Symptoms Before, During, and After Delirium: A Literature Review. | Nelson S, Rustad JK, Catalano G, Stern TA, Kozel FA | Psychosomatics | 2016 | |
| Rosuvastatin versus placebo for delirium in intensive care and subsequent cognitive impairment in patients with sepsis-associated acute respiratory distress syndrome: an ancillary study to a randomised controlled trial. | Needham DM, Colantuoni E, Dinglas VD, Hough CL, Wozniak AW, Jackson JC, Morris PE, Mendez-Tellez PA, Ely EW, Hopkins RO | The Lancet. Respiratory medicine | 2016 | |
| Cyproheptadine for the Prevention of Postoperative Delirium: A Pilot Study. | Mohammadi M, Ahmadi M, Khalili H, Cheraghchi H, Arbabi M | The Annals of pharmacotherapy | 2016 | |
| Delirium after surgical and transcatheter aortic valve replacement is associated with increased mortality. | Maniar HS, Lindman BR, Escallier K, Avidan M, Novak E, Melby SJ, Damiano MS, Lasala J, Quader N, Rao RS, Lawton J, Moon MR, Helsten D, Pasque MK, Damiano RJ, Zajarias A | The Journal of thoracic and cardiovascular surgery | 2016 | |
| The Efficacy of Earplugs as a Sleep Hygiene Strategy for Reducing Delirium in the ICU: A Systematic Review and Meta-Analysis. | Litton E, Carnegie V, Elliott R, Webb SA | Critical care medicine | 2016 | |
| Delirium in critical care: a study of incidence, prevalence, and associated factors in the tertiary care hospital of older Thai adults. | Limpawattana P, Panitchote A, Tangvoraphonkchai K, Suebsoh N, Eamma W, Chanthonglarng B, Tiamkao S | Aging & mental health | 2016 | |
| Comparison of cognitive and neuropsychiatric profiles in hospitalised elderly medical patients with delirium, dementia and comorbid delirium-dementia. | Leonard M, McInerney S, McFarland J, Condon C, Awan F, O'Connor M, Reynolds P, Meaney AM, Adamis D, Dunne C, Cullen W, Trzepacz PT, Meagher DJ | BMJ open | 2016 | |
| Identification of sub-groups in acutely ill elderly patients with delirium: a cluster analysis. | Lagarto L, Cerejeira J | International psychogeriatrics / IPA | 2016 | |
| Development and validation of the Thai version of the 4 'A's Test for delirium screening in hospitalized elderly patients with acute medical illnesses. | Kuladee S, Prachason T | Neuropsychiatric disease and treatment | 2016 | |
| Delirium is a risk factor for further cognitive decline in cognitively impaired hip fracture patients. | Krogseth M, Watne LO, Juliebø V, Skovlund E, Engedal K, Frihagen F, Wyller TB | Archives of gerontology and geriatrics | 2016 | |
| Surgical procedure and postoperative delirium in geriatric hip fracture patients. | Kavouspour C, Wang N, Mears SC, Oh ES, Sieber FE | European journal of anaesthesiology | 2016 | |
| The effect of range of motion exercises on delirium prevention among patients aged 65 and over in intensive care units. | Karadas C, Ozdemir L | Geriatric nursing (New York, N.Y.) | 2016 | |
| Managing verbal agitation in people with dementia and delirium. | Inkley F, Goldberg S | Nursing older people | 2016 | |
| The Fog of War: Delirium Prevalence in a Combat Intensive Care Unit. | Ingalls NK, Armstrong B, Hester M, Hatzfeld JJ, Robinson BR, Fortuna GR | Military medicine | 2016 | |
| General versus spinal anaesthesia and postoperative delirium in an orthogeriatric population. | Ilango S, Pulle RC, Bell J, Kuys SS | Australasian journal on ageing | 2016 | |
| Measuring delirium point-prevalence in two Australian palliative care inpatient units. | Hosie A, Lobb E, Agar M, Davidson P, Chye R, Lam L, Phillips J | International journal of palliative nursing | 2016 |
Aged, Aged, 80 and over, Australia, epidemiology, Cross-Sectional Studies, Delirium, diagnosis, Female, Humans, Inpatients, statistics & numerical data, Male, Mass Screening, statistics & numerical data, Middle Aged, Palliative Care, statistics & numerical data, Prevalence, Prospective Studies |
| The Relationship Between Sleep-Wake Cycle Disturbance and Trajectory of Cognitive Recovery During Acute Traumatic Brain Injury. | Holcomb EM, Towns S, Kamper JE, Barnett SD, Sherer M, Evans C, Nakase-Richardson R | The Journal of head trauma rehabilitation | 2016 | |
| Effectiveness of the STOPP/START (Screening Tool of Older Persons' potentially inappropriate Prescriptions/Screening Tool to Alert doctors to the Right Treatment) criteria: systematic review and meta-analysis of randomized controlled studies. | Hill-Taylor B, Walsh KA, Stewart S, Hayden J, Byrne S, Sketris IS | Journal of clinical pharmacy and therapeutics | 2016 | |
| Impact of multicomponent, nonpharmacologic interventions on perioperative cortisol and melatonin levels and postoperative delirium in elderly oral cancer patients. | Guo Y, Sun L, Li L, Jia P, Zhang J, Jiang H, Jiang W | Archives of gerontology and geriatrics | 2016 |
Aged, Delirium, diagnosis, Female, Humans, Hydrocortisone, urine, Intensive Care Units, Male, Melatonin, urine, Middle Aged, Mouth Neoplasms, surgery, Postoperative Care, Postoperative Complications, prevention & control, Preoperative Care, Preoperative Period, Psychomotor Agitation, prevention & control, Sleep, drug effects, Treatment Outcome |
| Prevalence and risk factors of postoperative delirium in elderly hip fracture patients. | Guo Y, Jia P, Zhang J, Wang X, Jiang H, Jiang W | The Journal of international medical research | 2016 | |
| Prevalence of delirium among patients at a cancer ward: Clinical risk factors and prediction by bedside cognitive tests. | Grandahl MG, Nielsen SE, Koerner EA, Schultz HH, Arnfred SM | Nordic journal of psychiatry | 2016 | |
| Validation of the delirium observation screening scale in a hospitalized older population. | Gavinski K, Carnahan R, Weckmann M | Journal of hospital medicine | 2016 | |
| Delirium recall - an integrative review. | Fuller V | Journal of clinical nursing | 2016 | |
| Concordance between the delirium motor subtyping scale (DMSS) and the abbreviated version (DMSS-4) over longitudinal assessment in elderly medical inpatients. | Fitzgerald J, O'Regan N, Adamis D, Timmons S, Dunne C, Trzepacz P, Meagher D | International psychogeriatrics / IPA | 2016 | |
| Obesity and post-operative cognitive dysfunction: a systematic review and meta-analysis. | Feinkohl I, Winterer G, Pischon T | Diabetes/metabolism research and reviews | 2016 | |
| Antipsychotic-induced akathisia in delirium: A systematic review. | Espi Forcen F, Matsoukas K, Alici Y | Palliative & supportive care | 2016 | |
| Delirium in patients with advanced cancer. | Lawlor PG, Bruera ED | Hematology/oncology clinics of North America | 2002 |
Causality, Communication, Conscious Sedation, Delirium, diagnosis, Diagnosis, Differential, Ethics, Medical, Evidence-Based Medicine, Family, psychology, Humans, Mass Screening, Neoplasm Staging, Neoplasms, complications, Palliative Care, methods, Patient Advocacy, Practice Guidelines as Topic, Severity of Illness Index |
| Postdischarge Clinical Outcomes in Older Medical Patients with an Emergency Department Stay-Associated Delirium Onset. | Bo M, Bonetto M, Bottignole G, Porrino P, Coppo E, Tibaldi M, Ceci G, Raspo S, Cappa G, Bellelli G | Journal of the American Geriatrics Society | 2016 | |
| Stop Using Antipsychotics to Treat or Prevent Delirium-They Are No Better Than Placebo. | Barry HC | American family physician | 2016 | |
| Higher C-Reactive Protein Levels Predict Postoperative Delirium in Older Patients Undergoing Major Elective Surgery: A Longitudinal Nested Case-Control Study. | Dillon ST, Vasunilashorn SM, Ngo L, Otu HH, Inouye SK, Jones RN, Alsop DC, Kuchel GA, Metzger ED, Arnold SE, Marcantonio ER, Libermann TA | Biological psychiatry | 2016 | |
| Sex Differences in Hip Fracture Surgery: Preoperative Risk Factors for Delirium and Postoperative Outcomes. | Oh ES, Sieber FE, Leoutsakos JM, Inouye SK, Lee HB | Journal of the American Geriatrics Society | 2016 | |
| A Decrease in the Volume of Gray Matter as a Risk Factor for Postoperative Delirium Revealed by an Atlas-based Method. | Shioiri A, Kurumaji A, Takeuchi T, Nemoto K, Arai H, Nishikawa T | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2016 |