What is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!
How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.
Reference Information
- Title
- Common molecular and pathophysiological underpinnings of delirium and Alzheimer's disease: molecular signatures and therapeutic indications
- Authors
- Mosharaf, M. P. Alam, K. Gow, J. Mahumud, R. A. Mollah, M. N. H.
- Year
- 2024
- Journal
- BMC Geriatr
- Abstract
BACKGROUND: Delirium and Alzheimer’s disease (AD) are common causes of cognitive dysfunction among older adults. These neurodegenerative diseases share a common and complex relationship, and can occur individually or concurrently, increasing the chance of permanent mental dysfunction. However, the common molecular pathophysiology, key proteomic biomarkers, and functional pathways are largely unknown, whereby delirium is superimposed on AD and dementia. METHODS: We employed an integrated bioinformatics and system biology analysis approach to decipher such common key proteomic signatures, pathophysiological links between delirium and AD by analyzing the gene expression data of AD-affected human brain samples and comparing them with delirium-associated proteins. The present study identified the common drug target hub-proteins examining the protein-protein interaction (PPI) and gene regulatory network analysis. The functional enrichment and pathway analysis was conducted to reveal the common pathophysiological relationship. Finally, the molecular docking and dynamic simulation was used to computationally identify and validate the potential drug target and repurposable drugs for delirium and AD. RESULTS: We detected 99 shared differentially expressed genes (sDEGs) associated with AD and delirium. The sDEGs-set enrichment analysis detected the transmission across chemical synapses, neurodegeneration pathways, neuroinflammation and glutamatergic signaling pathway, oxidative stress, and BDNF signaling pathway as the most significant signaling pathways shared by delirium and AD. The disease-sDEGs interaction analysis highlighted the other disease risk factors with delirium and AD development and progression. Among the sDEGs of delirium and AD, the top 10 hub-proteins including ALB, APP, BDNF, CREB1, DLG4, GAD1, GAD2, GFAP, GRIN2B and GRIN2A were found by the PPI network analysis. Based on the maximum molecular docking binding affinities and molecular dynamic simulation (100 ns) results, the ALB and GAD2 were found as prominent drug target proteins when tacrine and donepezil were identified as potential drug candidates for delirium and AD. CONCLUSION: The study outlined the common key biomolecules and biological pathways shared by delirium and AD. The computationally reported potential drug molecules need a deeper investigation including clinical trials to validate their effectiveness. The outcomes from this study will help to understand the typical pathophysiological relationship between delirium and AD and flag future therapeutic development research for delirium.
- PMID
PMID: 39210294
PMICD: PMC11363673
- Keywords
Humans
*Alzheimer Disease/genetics/metabolism
*Delirium
Molecular Docking Simulation/methods
Aged
Computational Biology/methods
Protein Interaction Maps/physiology
Proteomics/methods
Biomarkers
Alzheimer’s disease
Common signaling pathways
Delirium
Drug repurposing
Essential drug targets
Molecular docking simulation
- Page(s)
- Volume
- Issue
| Title | Authors | Journal | Year | Keywords |
|---|---|---|---|---|
| Effects of a modified Hospital Elder Life Program on frailty in individuals undergoing major elective abdominal surgery. | Chen CC, Chen CN, Lai IR, Huang GH, Saczynski JS, Inouye SK | Journal of the American Geriatrics Society | 2014 |
Abdomen, surgery, Activities of Daily Living, Aged, Female, Frail Elderly, psychology, Geriatric Assessment, methods, Hospitalization, statistics & numerical data, Humans, Male, Odds Ratio, Postoperative Care, methods, Postoperative Complications, prevention & control, Surgical Procedures, Elective, Taiwan |
| First Spanish version of the Memorial Delirium Assessment Scale: psychometric properties, responsiveness, and factor loadings. | Noguera A, Carvajal A, Alonso-Babarro A, Chisholm G, Bruera E, Centeno C | Journal of pain and symptom management | 2014 | |
| Detection of delirium in palliative care unit patients: a prospective descriptive study of the Delirium Observation Screening Scale administered by bedside nurses. | Detroyer E, Clement PM, Baeten N, Pennemans M, Decruyenaere M, Vandenberghe J, Menten J, Joosten E, Milisen K | Palliative medicine | 2014 | |
| Intensive care delirium - effect on memories and health-related quality of life - a follow-up study. | Svenningsen H, Tønnesen EK, Videbech P, Frydenberg M, Christensen D, Egerod I | Journal of clinical nursing | 2014 | |
| Corticosteroids and transition to delirium in patients with acute lung injury. | Schreiber MP, Colantuoni E, Bienvenu OJ, Neufeld KJ, Chen KF, Shanholtz C, Mendez-Tellez PA, Needham DM | Critical care medicine | 2014 |
APACHE, Acute Lung Injury, complications, Adrenal Cortex Hormones, administration & dosage, Adult, Age Factors, Critical Illness, therapy, Delirium, diagnosis, Female, Humans, Intensive Care Units, Male, Markov Chains, Middle Aged, Organ Dysfunction Scores, Prospective Studies, Respiration, Artificial, Risk Factors, Severity of Illness Index, Treatment Outcome |
| Interprofessional education for delirium care: a systematic review. | Sockalingam S, Tan A, Hawa R, Pollex H, Abbey S, Hodges BD | Journal of interprofessional care | 2014 | |
| Delirium, a Symptom of UTI in the Elderly: Fact or Fable? A Systematic Review. | Balogun SA, Philbrick JT | Canadian geriatrics journal : CGJ | 2014 | |
| Improved analgesia, sedation, and delirium protocol associated with decreased duration of delirium and mechanical ventilation. | Dale CR, Kannas DA, Fan VS, Daniel SL, Deem S, Yanez ND, Hough CL, Dellit TH, Treggiari MM | Annals of the American Thoracic Society | 2014 | |
| Race and documentation of cognitive impairment in hospitalized older adults. | Campbell NL, Cantor BB, Hui SL, Perkins A, Khan BA, Farber MO, Nazir A, Garrett SL, Ely EW, Boustani MA | Journal of the American Geriatrics Society | 2014 |
Aged, Cognition, Cognition Disorders, diagnosis, Continental Population Groups, Female, Geriatric Assessment, methods, Health Records, Personal, Humans, Indiana, epidemiology, Inpatients, statistics & numerical data, Male, Mental Status Schedule, Prevalence, Questionnaires, Retrospective Studies, Risk Factors, Urban Population |
| Delirium in the cardiac surgical ICU. | Brown CH | Current opinion in anaesthesiology | 2014 | |
| Postoperative delirium in Parkinson's disease patients following deep brain stimulation surgery. | Carlson JD, Neumiller JJ, Swain LD, Mark J, McLeod P, Hirschauer J | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia | 2014 | |
| Prospective observational study of dementia in older patients admitted to acute hospitals. | Travers C, Byrne GJ, Pachana NA, Klein K, Gray LC | Australasian journal on ageing | 2014 | |
| Do patients of delirium have catatonic features? An exploratory study. | Grover S, Ghosh A, Ghormode D | Psychiatry and clinical neurosciences | 2014 | |
| Frequency and factors associated with falls in patients with advanced cancer presenting to an outpatient supportive care clinic. | Kuriya M, Yennurajalingam S, de la Cruz MG, Wei W, Palla S, Bruera E | Palliative & supportive care | 2015 | |
| Impact of anticholinergic discontinuation on cognitive outcomes in older people: a systematic review. | Salahudeen MS, Duffull SB, Nishtala PS | Drugs & aging | 2014 | |
| Patient frailty: the elephant in the operating room. | Hubbard RE, Story DA | Anaesthesia | 2014 |
Aged, Aged, 80 and over, Frail Elderly, statistics & numerical data, Geriatric Assessment, methods, Humans, Inpatients, statistics & numerical data, Risk Assessment, Risk Factors, Surgical Procedures, Operative |
| Should general anaesthesia be avoided in the elderly? | Strøm C, Rasmussen LS, Sieber FE | Anaesthesia | 2014 |
Aged, Aged, 80 and over, Anesthesia, General, adverse effects, Cognition Disorders, chemically induced, Delirium, chemically induced, Geriatric Assessment, methods, Humans, Postoperative Complications, chemically induced, Risk Factors |
| Cognitive interviews guide design of a new CAM patient expectations questionnaire. | Sherman KJ, Eaves ER, Ritenbaugh C, Hsu C, Cherkin DC, Turner JA | BMC complementary and alternative medicine | 2014 | |
| The association between C-reactive protein and delirium in 710 acute elderly hospital admissions. | Ritchie CW, Newman TH, Leurent B, Sampson EL | International psychogeriatrics / IPA | 2014 |
Acute Disease, Aged, Biological Markers, analysis, C-Reactive Protein, analysis, Cardiovascular Diseases, complications, Confusion, diagnosis, Delirium, blood, Female, Geriatric Assessment, methods, Hospitalization, statistics & numerical data, Humans, Infection, complications, London, Male, Musculoskeletal Diseases, complications, Neurologic Examination, methods, Prospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Statistics as Topic |
| The impact of acute brain dysfunction in the outcomes of mechanically ventilated cancer patients. | Almeida IC, Soares M, Bozza FA, Shinotsuka CR, Bujokas R, Souza-Dantas VC, Ely EW, Salluh JI | PloS one | 2014 | |
| Sedation and delirium in the intensive care unit. | Reade MC, Finfer S | The New England journal of medicine | 2014 |
Algorithms, Analgesics, adverse effects, Delirium, drug therapy, Humans, Hypnotics and Sedatives, administration & dosage, Intensive Care Units, Pain, complications, Postoperative Care, adverse effects, Postoperative Complications, drug therapy, Respiration, Artificial |
| New consciousness scale for delirium. | Neerland BE, Ahmed M, Watne LO, Hov KR, Wyller TB | Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række | 2014 |
Confusion, classification, Consciousness, classification, Delirium, classification, Humans, Norway, Observation, Severity of Illness Index, Translations |
| Missing link or not, mobilise against delirium. | Page VJ, Casarin A | Critical care (London, England) | 2014 | |
| Postoperative delirium in a substudy of cardiothoracic surgical patients in the BAG-RECALL clinical trial. | Whitlock EL, Torres BA, Lin N, Helsten DL, Nadelson MR, Mashour GA, Avidan MS | Anesthesia and analgesia | 2014 |
Aged, Anesthesia, General, Anesthetics, pharmacokinetics, Bayes Theorem, Cardiac Surgical Procedures, adverse effects, Confidence Intervals, Confusion, chemically induced, Consciousness Monitors, Delirium, etiology, Female, Humans, Intraoperative Period, Length of Stay, Logistic Models, Male, Middle Aged, Neuropsychological Tests, Postoperative Complications, psychology, Predictive Value of Tests, Thoracic Surgical Procedures, adverse effects, Treatment Outcome |
| Statin use and risk of delirium in the critically ill. | Page VJ, Davis D, Zhao XB, Norton S, Casarin A, Brown T, Ely EW, McAuley DF | American journal of respiratory and critical care medicine | 2014 |
Adult, Aged, Aged, 80 and over, Biological Markers, blood, C-Reactive Protein, metabolism, Critical Care, methods, Delirium, blood, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, therapeutic use, Intensive Care Units, Linear Models, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Outcome Assessment (Health Care), Propensity Score, Prospective Studies, Risk Factors |
| A relational ethical approach to end-of-life delirium. | Wright DK, Brajtman S, Macdonald ME | Journal of pain and symptom management | 2014 | |
| Rapidly reversible, sedation-related delirium versus persistent delirium in the intensive care unit. | Patel SB, Poston JT, Pohlman A, Hall JB, Kress JP | American journal of respiratory and critical care medicine | 2014 |
Adolescent, Adult, Aged, Aged, 80 and over, Conscious Sedation, adverse effects, Delirium, chemically induced, Female, Fentanyl, adverse effects, Follow-Up Studies, Humans, Hypnotics and Sedatives, adverse effects, Intensive Care, methods, Intensive Care Units, Length of Stay, statistics & numerical data, Logistic Models, Male, Middle Aged, Outcome Assessment (Health Care), Prognosis, Propofol, adverse effects, Proportional Hazards Models, Prospective Studies, Respiration, Artificial, statistics & numerical data, Single-Blind Method, Young Adult |
| Management of pain, agitation, and delirium in critically ill patients. | Pandharipande PP, Patel MB, Barr J | Polskie Archiwum Medycyny Wewnętrznej | 2014 | |
| Care and Respect for Elders in Emergencies program: a preliminary report of a volunteer approach to enhance care in the emergency department. | Sanon M, Baumlin KM, Kaplan SS, Grudzen CR | Journal of the American Geriatrics Society | 2014 |
Activities of Daily Living, Aged, Emergencies, Emergency Service, Hospital, standards, Female, Humans, Male, Patient Care Team, standards, Program Development, methods, Quality Improvement, Quality of Life, Retrospective Studies, Volunteers |
| Concordance between DSM-IV and DSM-5 criteria for delirium diagnosis in a pooled database of 768 prospectively evaluated patients using the delirium rating scale-revised-98. | Meagher DJ, Morandi A, Inouye SK, Ely W, Adamis D, Maclullich AJ, Rudolph JL, Neufeld K, Leonard M, Bellelli G, Davis D, Teodorczuk A, Kriesel S, Thomas C, Hasemann W, Timmons S, O Regan N, Grover S, Jabbar F, Cullen W, Dunne C, Kamholz B, Van Munster BC, | BMC medicine | 2014 | |
| Perioperative cognitive trajectory in adults. | Nadelson MR, Sanders RD, Avidan MS | British journal of anaesthesia | 2014 |
Affect, Cognition, physiology, Cognition Disorders, epidemiology, Critical Illness, Delirium, epidemiology, Dementia, epidemiology, Humans, Inflammation, psychology, Pain, Postoperative, epidemiology, Perioperative Period, psychology, Postoperative Complications, genetics, Quality of Life, Research |
| Underrepresentation of patients with pre-existing cognitive impairment in pharmaceutical trials on prophylactic or therapeutic treatments for delirium: a systematic review. | de Jonghe A, van de Glind EM, van Munster BC, de Rooij SE | Journal of psychosomatic research | 2014 | |
| Haloperidol prophylaxis does not prevent postoperative delirium in elderly patients: a randomized, open-label prospective trial. | Fukata S, Kawabata Y, Fujisiro K, Katagawa Y, Kuroiwa K, Akiyama H, Terabe Y, Ando M, Kawamura T, Hattori H | Surgery today | 2014 | |
| Transcranial Doppler to measure cerebral blood flow in delirium superimposed on dementia. A cohort study. | Caplan GA, Lan Z, Newton L, Kvelde T, McVeigh C, Hill MA | Journal of the American Medical Directors Association | 2014 | |
| Increasing anticholinergic burden and delirium in palliative care inpatients. | Zimmerman KM, Salow M, Skarf LM, Kostas T, Paquin A, Simone MJ, Rudolph J | Palliative medicine | 2014 | |
| Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial. | Hatta K, Kishi Y, Wada K, Takeuchi T, Odawara T, Usui C, Nakamura H, | JAMA psychiatry | 2014 |
Aged, Aged, 80 and over, Alzheimer Disease, diagnosis, Delirium, diagnosis, Female, Hospitals, General, Hospitals, University, Humans, Indenes, adverse effects, Kaplan-Meier Estimate, Male, Risk, Single-Blind Method |
| Delirium, agitation, and symptom distress within the final seven days of life among cancer patients receiving hospice care. | de la Cruz M, Noguera A, San Miguel-Arregui MT, Williams J, Chisholm G, Bruera E | Palliative & supportive care | 2015 |
Aged, Aged, 80 and over, Delirium, epidemiology, Female, Home Nursing, Hospice Care, Humans, Male, Middle Aged, Neoplasms, nursing, Predictive Value of Tests, Psychomotor Agitation, epidemiology, Retrospective Studies, Sensitivity and Specificity, Severity of Illness Index, Stress, Psychological, epidemiology, Surveys and Questionnaires, Terminal Care |
| Randomized ICU trials do not demonstrate an association between interventions that reduce delirium duration and short-term mortality: a systematic review and meta-analysis. | Al-Qadheeb NS, Balk EM, Fraser GL, Skrobik Y, Riker RR, Kress JP, Whitehead S, Devlin JW | Critical care medicine | 2014 |
Delirium, mortality, Intensive Care Units, Time Factors |
| Delirium detection based on monitoring of blinks and eye movements. | van der Kooi AW, Rots ML, Huiskamp G, Klijn FA, Koek HL, Kluin J, Leijten FS, Slooter AJ | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2014 | |
| Do patient characteristics influence nursing adherence to a guideline for preventing delirium? | Ijkema R, Langelaan M, van de Steeg L, Wagner C | Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing / Sigma Theta Tau | 2014 |
Aged, Aged, 80 and over, Delirium, nursing, Female, Guideline Adherence, statistics & numerical data, Humans, Male, Mass Screening, nursing, Medical Records, Nursing Evaluation Research, Patients, statistics & numerical data, Practice Guidelines as Topic, Retrospective Studies, Risk Assessment |
| Burden in caregivers of cognitively impaired elderly adults at time of hospitalization: a cross-sectional analysis. | Shankar KN, Hirschman KB, Hanlon AL, Naylor MD | Journal of the American Geriatrics Society | 2014 |
Activities of Daily Living, Adaptation, Psychological, Adolescent, Adult, Aged, Aged, 80 and over, Burnout, Professional, epidemiology, Caregivers, psychology, Cognition Disorders, nursing, Cross-Sectional Studies, Female, Humans, Incidence, Male, Middle Aged, United States, epidemiology, Young Adult |
| Recalibration of the delirium prediction model for ICU patients (PRE-DELIRIC): a multinational observational study. | van den Boogaard M, Schoonhoven L, Maseda E, Plowright C, Jones C, Luetz A, Sackey PV, Jorens PG, Aitken LM, van Haren FM, Donders R, van der Hoeven JG, Pickkers P | Intensive care medicine | 2014 | |
| UK medical teaching about ageing is improving but there is still work to be done: the Second National Survey of Undergraduate Teaching in Ageing and Geriatric Medicine. | Gordon AL, Blundell A, Dhesi JK, Forrester-Paton C, Forrester-Paton J, Mitchell HK, Bracewell N, Mjojo J, Masud T, Gladman JR | Age and ageing | 2014 | |
| Prevalence of frailty and its ability to predict in hospital delirium, falls, and 6-month mortality in hospitalized older patients. | Joosten E, Demuynck M, Detroyer E, Milisen K | BMC geriatrics | 2014 |
Accidental Falls, mortality, Aged, Aged, 80 and over, Delirium, diagnosis, Female, Frail Elderly, Geriatric Assessment, methods, Hospitalization, trends, Humans, Male, Predictive Value of Tests, Prevalence, Prospective Studies, Risk Factors |
| Delirium knowledge and recognition: a randomized controlled trial of a web-based educational intervention for acute care nurses. | McCrow J, Sullivan KA, Beattie ER | Nurse education today | 2014 | |
| A standardized, bundled approach to providing geriatric-focused acute care. | Mattison ML, Catic A, Davis RB, Olveczky D, Moran J, Yang J, Aronson M, Zeidel M, Lipsitz L, Marcantonio ER | Journal of the American Geriatrics Society | 2014 |
Academic Medical Centers, statistics & numerical data, Administration, Oral, Aged, Aged, 80 and over, Decision Support Techniques, Delirium, diagnosis, Delivery of Health Care, standards, Dose-Response Relationship, Drug, Female, Geriatric Assessment, Geriatrics, methods, Haloperidol, administration & dosage, Hospitalization, trends, Humans, Injections, Intramuscular, Injections, Intravenous, Male, Massachusetts, epidemiology, Mental Status Schedule, Morphine, administration & dosage, Prevalence, Prognosis, Retrospective Studies, Time Factors |
| Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people. | Bellelli G, Morandi A, Davis DH, Mazzola P, Turco R, Gentile S, Ryan T, Cash H, Guerini F, Torpilliesi T, Del Santo F, Trabucchi M, Annoni G, MacLullich AM | Age and ageing | 2014 | |
| Delirium superimposed on dementia strongly predicts worse outcomes in older rehabilitation inpatients. | Morandi A, Davis D, Fick DM, Turco R, Boustani M, Lucchi E, Guerini F, Morghen S, Torpilliesi T, Gentile S, MacLullich AM, Trabucchi M, Bellelli G | Journal of the American Medical Directors Association | 2014 | |
| Objective assessment of attention in delirium: a narrative review. | Tieges Z, Brown LJ, Maclullich AM | International journal of geriatric psychiatry | 2014 | |
| Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium. | Davis DH, Skelly DT, Murray C, Hennessy E, Bowen J, Norton S, Brayne C, Rahkonen T, Sulkava R, Sanderson DJ, Rawlins JN, Bannerman DM, MacLullich AM, Cunningham C | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry | 2015 | |
| Ethical challenges and solutions regarding delirium studies in palliative care. | Sweet L, Adamis D, Meagher DJ, Davis D, Currow DC, Bush SH, Barnes C, Hartwick M, Agar M, Simon J, Breitbart W, MacDonald N, Lawlor PG | Journal of pain and symptom management | 2014 | |
| Development of an abbreviated version of the delirium motor subtyping scale (DMSS-4). | Meagher D, Adamis D, Leonard M, Trzepacz P, Grover S, Jabbar F, Meehan K, O'Connor M, Cronin C, Reynolds P, Fitzgerald J, O'Regan N, Timmons S, Slor C, de Jonghe J, de Jonghe A, van Munster BC, de Rooij SE, Maclullich A | International psychogeriatrics / IPA | 2014 | |
| Treating an established episode of delirium in palliative care: expert opinion and review of the current evidence base with recommendations for future development. | Bush SH, Kanji S, Pereira JL, Davis DH, Currow DC, Meagher DJ, Rabheru K, Wright DK, Bruera E, Agar M, Hartwick M, Gagnon PR, Gagnon B, Breitbart W, Regnier L, Lawlor PG | Journal of pain and symptom management | 2014 | |
| Attention! A good bedside test for delirium? | O'Regan NA, Ryan DJ, Boland E, Connolly W, McGlade C, Leonard M, Clare J, Eustace JA, Meagher D, Timmons S | Journal of neurology, neurosurgery, and psychiatry | 2014 |
Adolescent, Adult, Aged, Aged, 80 and over, Attention, Confusion, diagnosis, Cross-Sectional Studies, Delirium, diagnosis, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Psychological Techniques, instrumentation, Sensitivity and Specificity, Young Adult |
| Palliative care in advanced dementia. | Merel S, DeMers S, Vig E | Clinics in geriatric medicine | 2014 | |
| Effect of medications with anti-cholinergic properties on cognitive function, delirium, physical function and mortality: a systematic review. | Fox C, Smith T, Maidment I, Chan WY, Bua N, Myint PK, Boustani M, Kwok CS, Glover M, Koopmans I, Campbell N | Age and ageing | 2014 | |
| Methodology of studying incident delirium after hip fracture. | Regal P | Journal of the American Geriatrics Society | 2014 |
Cholinergic Antagonists, blood, Delirium, diagnosis, Female, Hip Fractures, complications, Humans, Male |
| Delirium recognition by family: European portuguese validation study of the family confusion assessment method. | Martins S, Conceição F, Paiva JA, Simões MR, Fernandes L | Journal of the American Geriatrics Society | 2014 | |
| The assessment of the T102C polymorphism of the 5HT2a receptor gene, 3723G/A polymorphism of the NMDA receptor 3A subunit gene (GRIN3A) and 421C/A polymorphism of the NMDA receptor 2B subunit gene (GRIN2B) among cardiac surgery patients with and without d | Kazmierski J, Sieruta M, Banys A, Jaszewski R, Sobow T, Liberski P, Kloszewska I | General hospital psychiatry | 2014 | |
| Inflammation biomarkers and delirium in critically ill patients: new insights? | Sobbi SC, van den Boogaard M | Critical care (London, England) | 2014 | |
| Delirium among critically ill adults: Evaluation of the psychometric properties of the Italian 'Confusion Assessment Method for the Intensive Care Unit'. | Gaspardo P, Peressoni L, Comisso I, Mistraletti G, Ely EW, Morandi A | Intensive & critical care nursing : the official journal of the British Association of Critical Care Nurses | 2014 | |
| Delirium in older people in hospital: an education programme. | Varghese NC, Macaden L, Premkumar B, Mathews P, Kumar S | British journal of nursing (Mark Allen Publishing) | 2014 |
Adult, Aged, Aged, 80 and over, Curriculum, Delirium, diagnosis, Education, Nursing, Continuing, Female, Geriatric Assessment, Great Britain, Health Knowledge, Attitudes, Practice, Humans, India, Male, Middle Aged, Nurse-Patient Relations, Nursing Staff, Hospital, education, Program Evaluation, Young Adult |
| Burst suppression on processed electroencephalography as a predictor of postcoma delirium in mechanically ventilated ICU patients. | Andresen JM, Girard TD, Pandharipande PP, Davidson MA, Ely EW, Watson PL | Critical care medicine | 2014 |
APACHE, Aged, Brain, physiopathology, Coma, complications, Deep Sedation, adverse effects, Delirium, diagnosis, Electroencephalography, statistics & numerical data, Female, Humans, Intensive Care Units, statistics & numerical data, Logistic Models, Male, Middle Aged, Prognosis, Proportional Hazards Models, Prospective Studies, Respiration, Artificial, adverse effects |
| Postoperative plasma copeptin levels independently predict delirium and cognitive dysfunction after coronary artery bypass graft surgery. | Dong S, Li CL, Liang WD, Chen MH, Bi YT, Li XW | Peptides | 2014 | |
| Evaluation of a nurse mentoring intervention to family caregivers in the management of delirium after cardiac surgery (MENTOR_D): a study protocol for a randomized controlled pilot trial. | Mailhot T, Cossette S, Bourbonnais A, Côté J, Denault A, Côté MC, Lamarche Y, Guertin MC | Trials | 2014 | |
| Delirium in older persons: evaluation and management. | Kalish VB, Gillham JE, Unwin BK | American family physician | 2014 |
Aged, Aged, 80 and over, Delirium, diagnosis, Female, Humans, Risk Factors |
| Delirium: another factor when considering type of anesthetic for hip fracture surgery in adults. | Gupta N | BMJ (Clinical research ed.) | 2014 | |
| Improving delirium care for hospitalized older patients. A qualitative study identifying barriers to guideline adherence. | van de Steeg L, Langelaan M, Ijkema R, Nugus P, Wagner C | Journal of evaluation in clinical practice | 2014 | |
| A prospective observational study to investigate the association between abnormal hand movements and delirium in hospitalised older people. | Holt R, Teale EA, Mulley GP, Young J | Age and ageing | 2015 |
Aged, 80 and over, Delirium, diagnosis, England, Female, Geriatric Assessment, Hand, innervation, Hospital Mortality, Hospitalization, Hospitals, General, Humans, Inpatients, Male, Motor Activity, Predictive Value of Tests, Prospective Studies, Time Factors |
| Prevalence of delirium in opium users after coronary artery bypass graft surgery. | Eizadi-Mood N, Aghadavoudi O, Najarzadegan MR, Fard MM | International journal of preventive medicine | 2014 | |
| Delirium and hypovitaminosis D: neuroimaging findings. | Bourgeois JA, Hategan A, Ford J, Tisi DK, Xiong GL | The Journal of neuropsychiatry and clinical neurosciences | 2015 | |
| Tryptophan supplementation and postoperative delirium-a randomized controlled trial. | Robinson TN, Dunn CL, Adams JC, Hawkins CL, Tran ZV, Raeburn CD, Moss M | Journal of the American Geriatrics Society | 2014 | |
| Cerebrospinal fluid markers of neuroinflammation in delirium: A role for interleukin-1β in delirium after hip fracture. | Cape E, Hall RJ, van Munster BC, de Vries A, Howie SE, Pearson A, Middleton SD, Gillies F, Armstrong IR, White TO, Cunningham C, de Rooij SE, MacLullich AM | Journal of psychosomatic research | 2014 | |
| Association between combative behavior requiring intervention and delirium in hospitalized patients. | Uldall K, Williams BL, Dunn JD, Blackmore CC | Journal of hospital medicine : an official publication of the Society of Hospital Medicine | 2014 | |
| Recognition and management of delirium among doctors, nurses, physiotherapists, and psychologists: an Italian survey. | Bellelli G, Morandi A, Zanetti E, Bozzini M, Lucchi E, Terrasi M, Trabucchi M | International psychogeriatrics / IPA | 2014 | |
| A nationwide study on delirium in psychiatric patients from 1995 to 2011. | Lundberg AS, Okkels N, Gustafsson LN, Larsen JT, Sørensen LU, Munk-Jørgensen P | Acta neuropsychiatrica | 2014 | |
| Changing perspectives on delirium care: The new Dutch guideline on delirium. | Leentjens AF, Molag ML, Van Munster BC, De Rooij SE, Luijendijk HJ, Vochteloo AJ, Dautzenberg PL, | Journal of psychosomatic research | 2014 | |
| The Relationship Between a Chief Complaint of "Altered Mental Status" and Delirium in Older Emergency Department Patients. | Han JH, Schnelle JF, Ely EW | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine | 2014 | |
| Promoting Sleep in the Adult Surgical Intensive Care Unit Patients to Prevent Delirium. | Hata RK, Han L, Slade J, Miyahira A, Passion C, Ghows M, Izumi K, Yu M | The Nursing clinics of North America | 2014 | |
| Experience in delirium: is it distressing? | Grover S, Ghosh A, Ghormode D | The Journal of neuropsychiatry and clinical neurosciences | 2015 | |
| Delirium detection using EEG: what and how to measure. | van der Kooi AW, Zaal IJ, Klijn FA, Koek HL, Meijer RC, Leijten FS, Slooter AJ | Chest | 2015 | |
| Efficacy and safety of haloperidol prophylaxis for delirium prevention in older medical and surgical at-risk patients acutely admitted to hospital through the emergency department: study protocol of a multicenter, randomised, double-blind, placebo-control | Schrijver EJ, de Vries OJ, Verburg A, de Graaf K, Bet PM, van de Ven PM, Kamper AM, Diepeveen SH, Anten S, Siegel A, Kuipéri E, Lagaay AM, van Marum RJ, van Strien AM, Boelaarts L, Pons D, Kramer MH, Nanayakkara PW | BMC geriatrics | 2014 | |
| Do stress markers and anesthetic technique predict delirium in the elderly? | Deiner S, Lin HM, Bodansky D, Silverstein J, Sano M | Dementia and geriatric cognitive disorders | 2014 | |
| Hospital delirium and psychological distress at 1 year and health-related quality of life after moderate-to-severe traumatic injury without intracranial hemorrhage. | Abraham CM, Obremskey WT, Song Y, Jackson JC, Ely EW, Archer KR | Archives of physical medicine and rehabilitation | 2014 |
Adult, Delirium, psychology, Depression, epidemiology, Female, Follow-Up Studies, Hospitalization, Humans, Intensive Care Units, Male, Middle Aged, Psychiatric Status Rating Scales, Quality of Life, psychology, Stress Disorders, Post-Traumatic, epidemiology, Time Factors, Trauma Severity Indices, Wounds and Injuries, psychology |
| Recognizing changes in cognition in sub types of acute confusional state. | Mushtaq R, Shoib S, Shah T, Dar MM, Mushtaq S | Journal of clinical and diagnostic research : JCDR | 2014 | |
| Delirium in patients with cancer: assessment, impact, mechanisms and management. | Lawlor PG, Bush SH | Nature reviews. Clinical oncology | 2015 | |
| Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial. | de Jonghe A, van Munster BC, Goslings JC, Kloen P, van Rees C, Wolvius R, van Velde R, Levi M, de Haan RJ, de Rooij SE, | CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne | 2014 |
Aged, Aged, 80 and over, Arthroplasty, Replacement, Hip, adverse effects, Delirium, epidemiology, Double-Blind Method, Female, Fracture Fixation, Internal, adverse effects, Hip Fractures, complications, Humans, Incidence, Male, Melatonin, therapeutic use |
| Short-term cognitive effects after recovery from a delirium in a hospitalized elderly sample. | Mark RE, Muselaers N, Scholten H, van Boxtel A, Eerenberg T | The Journal of nervous and mental disease | 2014 |
Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Comorbidity, Cross-Sectional Studies, Delirium, complications, Dementia, epidemiology, Diabetes Mellitus, epidemiology, Executive Function, physiology, Female, Geriatric Assessment, Hospitalization, Humans, Male, Neuropsychological Tests, Recovery of Function, physiology, Time Factors |
| Sleep-disordered breathing is a risk factor for delirium after cardiac surgery: a prospective cohort study. | Roggenbach J, Klamann M, von Haken R, Bruckner T, Karck M, Hofer S | Critical care (London, England) | 2014 | |
| Haloperidol, risperidone, olanzapine and aripiprazole in the management of delirium: A comparison of efficacy, safety, and side effects. | Boettger S, Jenewein J, Breitbart W | Palliative & supportive care | 2014 | |
| Delirium and severe illness: Etiologies, severity of delirium and phenomenological differences. | Boettger S, Jenewein J, Breitbart W | Palliative & supportive care | 2015 |
Adult, Aged, Aged, 80 and over, Critical Illness, nursing, Delirium, diagnosis, Dementia, diagnosis, Female, Humans, Karnofsky Performance Status, Male, Middle Aged, Neoplasms, complications, Severity of Illness Index |
| Delirium in advanced age and dementia: A prolonged refractory course of delirium and lower functional status. | Boettger S, Jenewein J, Breitbart W | Palliative & supportive care | 2014 | |
| ICU delirium: A survey into nursing and medical staff knowledge of current practices and perceived barriers towards ICU delirium in the intensive care unit. | Elliott SR | Intensive & critical care nursing : the official journal of the British Association of Critical Care Nurses | 2014 | |
| Perioperative gabapentin and delirium following total knee arthroplasty: a post-hoc analysis of a double-blind randomized placebo-controlled trial. | Dighe K, Clarke H, McCartney CJ, Wong CL | Canadian journal of anaesthesia = Journal canadien d'anesthésie | 2014 | |
| ICU architectural design affects the delirium prevalence: a comparison between single-bed and multibed rooms*. | Caruso P, Guardian L, Tiengo T, Dos Santos LS, Junior PM | Critical care medicine | 2014 |
Cancer Care Facilities, standards, Delirium, epidemiology, Female, Hospital Bed Capacity, 100 to 299, Hospital Design and Construction, standards, Hospitals, Teaching, standards, Humans, Intensive Care Units, standards, Male, Middle Aged, Patients’ Rooms, standards, Prevalence, Retrospective Studies, Risk Factors |
| Evaluation of the Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle: Several Confounders to be Considered. | Yang L, Ye L, Zheng Z, Zhang M | Critical care medicine | 2014 | |
| Community-based rehabilitation post hospital discharge interventions for older adults with cognitive impairment following a hip fracture: a systematic review protocol. | van Wyk PM, Chu CH, Babineau J, Puts M, Brooks D, Saragosa M, McGilton KS | JMIR research protocols | 2014 | |
| Delirium transitions in the medical ICU: exploring the role of sleep quality and other factors. | Kamdar BB, Niessen T, Colantuoni E, King LM, Neufeld KJ, Bienvenu OJ, Rowden AM, Collop NA, Needham DM | Critical care medicine | 2015 |
Age Factors, Aged, Delirium, etiology, Female, Humans, Hypnotics and Sedatives, adverse effects, Intensive Care Units, statistics & numerical data, Male, Middle Aged, Questionnaires, Respiration, Artificial, adverse effects, Risk Factors, Sex Factors, Sleep, Sleep Deprivation, complications |
| Pain, delirium, and physical function in skilled nursing home patients with dementia. | Kolanowski A, Mogle J, Fick DM, Hill N, Mulhall P, Nadler J, Colancecco E, Behrens L | Journal of the American Medical Directors Association | 2015 | |
| Effect of the overlap syndrome of depressive symptoms and delirium on outcomes in elderly adults with hip fracture: a prospective cohort study. | Radinovic KS, Markovic-Denic L, Dubljanin-Raspopovic E, Marinkovic J, Jovanovic LB, Bumbasirevic V | Journal of the American Geriatrics Society | 2014 |