Delirium Bibliography

Delirium Bibliography books graphicWhat is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title
Fixed dose ketamine for prehospital management of hyperactive delirium with severe agitation
Authors
O'Brien, M. C. Kelleran, K. J. Burnett, S. J. Hausrath, K. A. Kneer, M. S. Nan, N. Ma, C. X. McCartin, R. W. Clemency, B. M.
Year
2024
Journal
Am J Emerg Med
Abstract

INTRODUCTION: Patients exhibiting signs of hyperactive delirium with severe agitation (HDSA) may require sedating medications for stabilization and safe transport to the hospital. Determining the patient’s weight and calculating the correct weight-based dose may be challenging in an emergency. A fixed dose ketamine protocol is an alternative to the traditional weight-based administration, which may also reduce dosing errors. The objective of this study was to evaluate the frequency and characteristics of adverse events following pre-hospital ketamine administration for HDSA. METHODS: Emergency Medical Services (EMS) records from four agencies were searched for prehospital ketamine administration. Cases were included if a 250 mg dose of ketamine was administered on standing order to an adult patient for clinical signs consistent with HDSA. Protocols allowed for a second 250 mg dose of ketamine if the first dose was not effective. Both the 250 mg initial dose and the total prehospital dose were analyzed for weight based dosing and adverse events. RESULTS: Review of 132 cases revealed 60 cases that met inclusion criteria. Patients’ median weight was 80 kg (range: 50-176 kg). No patients were intubated by EMS, one only requiring suction, three required respiratory support via bag valve mask (BVM). Six (10%) patients were intubated in the emergency department (ED) including the three (5%) supported by EMS via BVM, three (5%) others who were sedated further in the ED prior to requiring intubation. All six patients who were intubated were discharged from the hospital with a Cerebral Performance Category (CPC) 1 score. The weight-based dosing equivalent for the 250 mg initial dose (OR: 2.62, CI: 0.67-10.22) and the total prehospital dose, inclusive of the 12 patients that were administered a second dose, (OR: 0.74, CI: 0.27, 2.03), were not associated with the need for intubation. CONCLUSION: The 250 mg fixed dose of ketamine was not >5 mg/kg weight-based dose equivalent for all patients in this study. Although a second 250 mg dose of ketamine was permitted under standing orders, only 12 (20%) of the patients were administered a second dose, none experienced an adverse event. This indicates that the 250 mg initial dose was effective for 80% of the patients. Four patients with prehospital adverse events likely related to the administration of ketamine were found. One required suction, three (5%) requiring BVM respiratory support by EMS were subsequently intubated upon arrival in the ED. All 60 patients were discharged from the hospital alive. Further research is needed to determine an optimal single administration dose for ketamine in patients exhibiting signs of HDSA, if employing a standardized fixed dose medication protocol streamlines administration, and if the fixed dose medication reduces the occurrence of dosage errors.

PMID

PMID: 38626643

Keywords

Humans
*Ketamine/administration & dosage/therapeutic use
*Delirium/drug therapy
*Emergency Medical Services/methods
Male
Female
Middle Aged
*Psychomotor Agitation/drug therapy
Aged
Adult
Retrospective Studies
Aged, 80 and over
Anesthetics, Dissociative/administration & dosage/therapeutic use
Body Weight
Hyperactive delirium
Ketamine
Prehospital care
Sedation
Weight-based dose

Page(s)
Issue

Search:
Total Records Found: 6080, showing 100 per page
TitleAuthorsJournalYearKeywords
Exploring the utility of ultra-brief delirium assessments in a nonintensive care geriatric population: the GEM study. Powers JS, Doering T, Gordon S, Eden SK, Shintani A, Schnelle J The Gerontologist 2013

Aged, Aged, 80 and over, Delirium, diagnosis, Female, Geriatric Assessment, statistics & numerical data, Health Services for the Aged, utilization, Humans, Male, Mental Health, Middle Aged, Prospective Studies, Psychometrics, methods

Antipsychotic use in nursing home residents admitted with hip fracture. Jung HY, Meucci M, Unruh MA, Mor V, Dosa D Journal of the American Geriatrics Society 2013

Activities of Daily Living, Aged, Aged, 80 and over, Antipsychotic Agents, therapeutic use, Delirium, complications, Female, Follow-Up Studies, Hip Fractures, complications, Hospitalization, statistics & numerical data, Humans, Incidence, Male, Nursing Homes, Population Surveillance, Prevalence, Retrospective Studies, United States, epidemiology

Association between endothelial dysfunction and acute brain dysfunction during critical illness. Hughes CG, Morandi A, Girard TD, Riedel B, Thompson JL, Shintani AK, Pun BT, Ely EW, Pandharipande PP Anesthesiology 2013

Acute Disease, Aged, Brain Diseases, epidemiology, Cohort Studies, Coma, epidemiology, Critical Illness, epidemiology, Delirium, epidemiology, Endothelium, Vascular, physiopathology, Female, Humans, Male, Middle Aged, Prospective Studies

Delirium-related distress in caregivers: a study from a tertiary care centre in India. Grover S, Shah R Perspectives in psychiatric care 2013

Adult, Aged, Caregivers, psychology, Cost of Illness, Delirium, diagnosis, Female, Humans, India, Male, Middle Aged, Nursing Assessment, Prospective Studies, Referral and Consultation, Tertiary Care Centers, Young Adult

Diagnostic accuracy of a rapid checklist to identify delirium in older patients transported by EMS. Frisch A, Miller T, Haag A, Martin-Gill C, Guyette FX, Suffoletto BP Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors 2013

Aged, Aged, 80 and over, Case-Control Studies, Checklist, Delirium, diagnosis, Emergency Medical Services, Female, Geriatric Assessment, methods, Glasgow Coma Scale, Humans, Male, Matched-Pair Analysis, Pennsylvania, Prospective Studies, Reproducibility of Results, Sensitivity and Specificity

Three core domains of delirium validated using exploratory and confirmatory factor analyses. Franco JG, Trzepacz PT, Meagher DJ, Kean J, Lee Y, Kim JL, Kishi Y, Furlanetto LM, Negreiros D, Huang MC, Chen CH, Leonard M, de Pablo J Psychosomatics 2013

Adult, Analysis of Variance, Chronobiology Disorders, diagnosis, Cognition Disorders, diagnosis, Cross-Sectional Studies, Data Interpretation, Statistical, Delirium, diagnosis, Diagnostic and Statistical Manual of Mental Disorders, Factor Analysis, Statistical, Female, Humans, Male, Models, Statistical, Reproducibility of Results, Severity of Illness Index, Symptom Assessment, statistics & numerical data

Delirium in the cardiovascular ICU: exploring modifiable risk factors. McPherson JA, Wagner CE, Boehm LM, Hall JD, Johnson DC, Miller LR, Burns KM, Thompson JL, Shintani AK, Ely EW, Pandharipande PP, Pandhvaripande PP Critical care medicine 2013

Age Factors, Aged, Benzodiazepines, administration & dosage, Coma, epidemiology, Coronary Care Units, Critical Illness, Delirium, diagnosis, Female, Humans, Intensive Care Units, Logistic Models, Male, Middle Aged, Prevalence, Prospective Studies, Restraint, Physical, statistics & numerical data, Risk Factors, Time Factors

Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Barr J, Fraser GL, Puntillo K, Ely EW, Gélinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, Coursin DB, Herr DL, Tung A, Robinson BR, Fontaine DK, Ramsay MA, Riker RR, Sessler CN, Pun B, Skrobik Y, Jaeschke R, Critical care medicine 2013

Adult, Clinical Protocols, Critical Illness, Delirium, diagnosis, Humans, Hypnotics and Sedatives, adverse effects, Intensive Care Units, Pain Management, methods, Pain Measurement, methods, Psychomotor Agitation, diagnosis, Risk Assessment, methods, United States

Effect of intensive care unit environment on in-hospital delirium after cardiac surgery. Arenson BG, MacDonald LA, Grocott HP, Hiebert BM, Arora RC The Journal of thoracic and cardiovascular surgery 2013

Aged, Cardiac Surgical Procedures, Delirium, epidemiology, Female, Hospitals, Humans, Intensive Care Units, Male, Middle Aged, Postoperative Complications, epidemiology, Retrospective Studies

Parenteral hydration in patients with advanced cancer: a multicenter, double-blind, placebo-controlled randomized trial. Bruera E, Hui D, Dalal S, Torres-Vigil I, Trumble J, Roosth J, Krauter S, Strickland C, Unger K, Palmer JL, Allo J, Frisbee-Hume S, Tarleton K Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013

Adult, Aged, Aged, 80 and over, Dehydration, therapy, Double-Blind Method, Fatigue, prevention & control, Female, Fluid Therapy, Follow-Up Studies, Hospice Care, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, complications, Neoplasms, complications, Parenteral Nutrition, Prognosis, Quality of Life, Survival Rate, Symptom Assessment

Delirium assessment using Confusion Assessment Method for the Intensive Care Unit in Chinese critically ill patients. Wang C, Wu Y, Yue P, Ely EW, Huang J, Yang X, Liu Y Journal of critical care 2013

APACHE, Activities of Daily Living, Aged, Chi-Square Distribution, China, Confusion, diagnosis, Critical Illness, Delirium, diagnosis, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Intensive Care Units, Male, Middle Aged, Predictive Value of Tests, Reproducibility of Results, Sensitivity and Specificity, Translations

Incidence, risk factors, and complications of postoperative delirium in elderly patients undergoing radical cystectomy. Large MC, Reichard C, Williams JT, Chang C, Prasad S, Leung Y, DuBeau C, Bales GT, Steinberg GD Urology 2013

Age Factors, Aged, Aged, 80 and over, Case-Control Studies, Confidence Intervals, Cystectomy, adverse effects, Delirium, etiology, Female, Humans, Kaplan-Meier Estimate, Male, Mental Status Schedule, Multivariate Analysis, Odds Ratio, Patient Readmission, Pilot Projects, Prospective Studies, Reoperation, Risk Factors, Urinary Bladder Neoplasms, surgery

Delirium in older patients: a diagnostic study of NEECHAM Confusion Scale in surgical intensive care unit. Matarese M, Generoso S, Ivziku D, Pedone C, De Marinis MG Journal of clinical nursing 2013

Aged, Confusion, diagnosis, Humans, Intensive Care Units, Prospective Studies, Surgery Department, Hospital

Subsyndromal delirium in older people: a systematic review of frequency, risk factors, course and outcomes. Cole MG, Ciampi A, Belzile E, Dubuc-Sarrasin M International journal of geriatric psychiatry 2013

Canada, epidemiology, Delirium, epidemiology, Europe, epidemiology, Humans, Incidence, Institutionalization, statistics & numerical data, Outcome Assessment (Health Care), Prevalence, Risk Factors, United States, epidemiology

Intensive care unit environment may affect the course of delirium. Zaal IJ, Spruyt CF, Peelen LM, van Eijk MM, Wientjes R, Schneider MM, Kesecioglu J, Slooter AJ Intensive care medicine 2013

Delirium, epidemiology, Female, Health Facility Environment, Humans, Intensive Care Units, Male, Middle Aged, Prospective Studies

The incidence of delirium in Norwegian intensive care units; deep sedation makes assessment difficult. Wøien H, Balsliemke S, Stubhaug A Acta anaesthesiologica Scandinavica 2013

Adolescent, Adult, Aged, Aged, 80 and over, Analgesics, therapeutic use, Coma, therapy, Critical Illness, Data Collection, Data Interpretation, Statistical, Deep Sedation, Delirium, diagnosis, Female, Humans, Intensive Care Units, statistics & numerical data, Logistic Models, Male, Middle Aged, Norway, epidemiology, Pain Measurement, Psychomotor Agitation, Young Adult

Replication analysis for composition of the Delirium Motor Subtype Scale (DMSS) in a referral cohort from Northern India. Grover S, Mattoo SK, Aarya KR, Pratim Das P, Chakrabarty K, Trzepacz P, Gupta N, Meagher D Psychiatry research 2013

Adolescent, Adult, Aged, Aged, 80 and over, Cohort Studies, Delirium, classification, Female, Humans, India, Male, Middle Aged, Movement Disorders, classification, Principal Component Analysis, Psychiatric Status Rating Scales, Referral and Consultation, Severity of Illness Index, Young Adult

Prospective observational study of dementia and delirium in the acute hospital setting. Travers C, Byrne G, Pachana N, Klein K, Gray L Internal medicine journal 2013

Aged, Aged, 80 and over, Cohort Studies, Delirium, diagnosis, Dementia, diagnosis, Female, Hospitalization, trends, Humans, Male, Observational Study as Topic, methods, Patient Admission, trends, Prospective Studies, Queensland, epidemiology

Melatonin receptor agonists for treating delirium in elderly patients with acute stroke. Ohta T, Murao K, Miyake K, Takemoto K Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2013

Aged, Aged, 80 and over, Delirium, complications, Female, Humans, Indenes, therapeutic use, Male, Middle Aged, Prognosis, Receptors, Melatonin, agonists, Stroke, complications, Treatment Outcome

Selecting optimal screening items for delirium: an application of item response theory. Yang FM, Jones RN, Inouye SK, Tommet D, Crane PK, Rudolph JL, Ngo LH, Marcantonio ER BMC medical research methodology 2013

Aged, 80 and over, Algorithms, Delirium, diagnosis, Factor Analysis, Statistical, Female, Humans, Male, Psychometrics, Questionnaires

Relation of serum cortisol to delirium occurring after acute coronary syndromes. Colkesen Y, Giray S, Ozenli Y, Sezgin N, Coskun I The American journal of emergency medicine 2013

Acute Coronary Syndrome, complications, Aged, Delirium, blood, Female, Humans, Hydrocortisone, blood, Logistic Models, Male, Middle Aged, Psychiatric Status Rating Scales, ROC Curve, Risk Assessment, Sensitivity and Specificity, Severity of Illness Index

Vitamin D and delirium in critically ill patients: a preliminary investigation. Morandi A, Barnett N, Miller RR, Girard TD, Pandharipande PP, Ely EW, Ware LB Journal of critical care 2013

Acute Lung Injury, diagnosis, Adult, Age Factors, Critical Illness, Delirium, blood, Female, Humans, Intensive Care Units, Logistic Models, Male, Middle Aged, Pilot Projects, Prospective Studies, Risk Factors, Severity of Illness Index, Vitamin D Deficiency, blood

Delirium within the emergency care setting, occurrence and detection: a systematic review. Barron EA, Holmes J Emergency medicine journal : EMJ 2013

Cohort Studies, Cross-Sectional Studies, Delirium, epidemiology, Emergency Service, Hospital, statistics & numerical data, Great Britain, epidemiology, Humans, Incidence, Prevalence

Delirium and transition to a nursing home of hospitalized older adults: a controlled trial of assessing the interdisciplinary team-based "geriatric" care and care coordination by non-geriatrics specialist physicians. Yoo JW, Nakagawa S, Kim S Geriatrics & gerontology international 2013

Activities of Daily Living, Aged, Aged, 80 and over, Case Management, Case-Control Studies, Checklist, Cognition, physiology, Delirium, prevention & control, Diagnosis, Female, Follow-Up Studies, Geriatric Assessment, Geriatrics, education, Hospitalization, Humans, Intervention Studies, Male, Medication Reconciliation, Medicine, Mental Status Schedule, Nursing Homes, Outcome Assessment (Health Care), Patient Care Team, Patient Transfer, Residence Characteristics, Severity of Illness Index, Sleep, physiology

Impact of pneumonia on hyperactive delirium in end-stage lung cancer patients. Suzuki H, Hirashima T, Kobayashi M, Okamoto N, Matsuura Y, Tamiya M, Morishita N, Okafuji K, Shiroyama T, Morimura O, Morita S, Kawase I Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2013

Adult, Aged, Aged, 80 and over, Case-Control Studies, Delirium, epidemiology, Female, Humans, Incidence, Japan, epidemiology, Logistic Models, Lung Neoplasms, epidemiology, Male, Middle Aged, Multivariate Analysis, Palliative Care, Pneumonia, epidemiology, Psychomotor Agitation, epidemiology, Retrospective Studies, Risk Factors

Improving quality of delirium care in a general medical service with established interdisciplinary care: a controlled trial. Mudge AM, Maussen C, Duncan J, Denaro CP Internal medicine journal 2013

Aged, Aged, 80 and over, Delirium, diagnosis, Female, General Practice, standards, Hospital Departments, standards, Humans, Male, Patient Care Team, standards, Patient Discharge, standards, Quality Improvement, standards

Incidence of post-stroke delirium and 1-year outcome. Miu DK, Yeung JC Geriatrics & gerontology international 2013

Aged, Aged, 80 and over, Biological Markers, analysis, Comorbidity, Delirium, epidemiology, Demography, Female, Hong Kong, epidemiology, Humans, Incidence, Length of Stay, statistics & numerical data, Logistic Models, Male, Middle Aged, Risk Factors, Stroke, complications, Survival Rate

Prevalence, presentation and prognosis of delirium in older people in the population, at home and in long term care: a review. de Lange E, Verhaak PF, van der Meer K International journal of geriatric psychiatry 2013

Delirium, epidemiology, Home Care Services, statistics & numerical data, Humans, Long-Term Care, statistics & numerical data, Prevalence, Prognosis, Risk Factors

Postoperative course after emergency colorectal surgery for secondary peritonitis in the elderly is often complicated by delirium. Engelberger S, Zürcher M, Schuld J, Viehl CT, Kettelhack C International surgery 2012

APACHE, Age Factors, Aged, Aged, 80 and over, Colon, surgery, Decision Support Techniques, Delirium, diagnosis, Emergencies, Female, Humans, Male, Peritonitis, etiology, Postoperative Complications, epidemiology, Rectum, surgery, Retrospective Studies, Risk Factors, Severity of Illness Index, Treatment Outcome

Cortical signatures of cognition and their relationship to Alzheimer's disease. Gross AL, Manly JJ, Pa J, Johnson JK, Park LQ, Mitchell MB, Melrose RJ, Inouye SK, McLaren DG, Brain imaging and behavior 2012

Aged, Aged, 80 and over, Alzheimer Disease, complications, Brain, pathology, Diagnosis, Computer-Assisted, methods, Female, Humans, Magnetic Resonance Imaging, methods, Male, Middle Aged, Mild Cognitive Impairment, complications, Neuropsychological Tests, Psychometrics, methods, Reproducibility of Results, Sensitivity and Specificity, Severity of Illness Index

Parallel but not equivalent: challenges and solutions for repeated assessment of cognition over time. Gross AL, Inouye SK, Rebok GW, Brandt J, Crane PK, Parisi JM, Tommet D, Bandeen-Roche K, Carlson MC, Jones RN Journal of clinical and experimental neuropsychology 2012

Aged, Aged, 80 and over, Cognition, Cognition Disorders, diagnosis, Female, Humans, Individuality, Longitudinal Studies, Male, Neuropsychological Tests, Verbal Learning

Novel risk markers and long-term outcomes of delirium: the successful aging after elective surgery (SAGES) study design and methods. Schmitt EM, Marcantonio ER, Alsop DC, Jones RN, Rogers SO, Fong TG, Metzger E, Inouye SK, Journal of the American Medical Directors Association 2012

Academic Medical Centers, Aged, Aging, Biological Markers, blood, Boston, Databases, Factual, Delirium, etiology, Female, Humans, Postoperative Complications, Prospective Studies, Qualitative Research, Research Design, Risk Assessment, methods, Surgical Procedures, Elective

Serial administration of a modified Richmond Agitation and Sedation Scale for delirium screening. Chester JG, Beth Harrington M, Rudolph JL, Journal of hospital medicine : an official publication of the Society of Hospital Medicine 2012

Aged, Aged, 80 and over, Cohort Studies, Delirium, diagnosis, Female, Humans, Male, Prospective Studies, Psychiatric Status Rating Scales, standards, Psychomotor Agitation, diagnosis

Intracranial cause of delirium: computed tomography yield and predictive factors. Lai MM, Wong Tin Niam DM Internal medicine journal 2012

Aged, Aged, 80 and over, Australia, Brain, pathology, Brain Diseases, complications, Case-Control Studies, Delirium, etiology, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Risk Factors, Sensitivity and Specificity, Tomography, X-Ray Computed

Role of microglia and toll-like receptor 4 in the pathophysiology of delirium. Jalleh R, Koh K, Choi B, Liu E, Maddison J, Hutchinson MR Medical hypotheses 2012

Aged, Delirium, physiopathology, Humans, Microglia, pathology, Middle Aged, Models, Theoretical, Toll-Like Receptor 4, physiology

Non-steroidal anti-inflammatory drugs and cognitive function: are prostaglandins at the heart of cognitive impairment in dementia and delirium? Cunningham C, Skelly DT Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012

Animals, Anti-Inflammatory Agents, Non-Steroidal, pharmacology, Cognition, drug effects, Cognition Disorders, immunology, Delirium, immunology, Dementia, immunology, Humans, Prostaglandins, immunology

Postoperative delirium in intensive care patients: risk factors and outcome. Veiga D, Luis C, Parente D, Fernandes V, Botelho M, Santos P, Abelha F Revista brasileira de anestesiologia 2012

Anesthesia Recovery Period

Delirium

Postoperative Complications

Risk Factors

Pain and cognitive dysfunction are the risk factors of delirium in elderly hip fracture Chinese patients. Nie H, Zhao B, Zhang YQ, Jiang YH, Yang YX Archives of gerontology and geriatrics 2012

Aged, China, epidemiology, Cognition Disorders, complications, Delirium, epidemiology, Female, Hip Fractures, complications, Humans, Incidence, Male, Neuropsychological Tests, Pain, complications, Pain Measurement, Postoperative Complications, etiology, Prospective Studies, Risk Factors

Pain reporting, opiate dosing, and the adverse effects of opiates after hip or knee replacement in patients 60 years old or older. Petre BM, Roxbury CR, McCallum JR, Defontes KW, Belkoff SM, Mears SC Geriatric orthopaedic surgery & rehabilitation 2012

Elderly

Hip Replacement

Knee Replacement

Opiates

Pain

Bright light therapy as an adjunctive treatment with risperidone in patients with delirium: a randomized, open, parallel group study. Yang J, Choi W, Ko YH, Joe SH, Han C, Kim YK General hospital psychiatry 2012

Adjunctive treatment

Delirium

Light Therapy

Sleep Efficiency

Total Sleep Time

Pharmacological risk factors for delirium after cardiac surgery: a review. Tse L, Schwarz SK, Bowering JB, Moore RL, Burns KD, Richford CM, Osborn JA, Barr AM Current neuropharmacology 2012

Cardiac surgery, Delirium, Drugs, Medications, Prevent, Risk Factors

One-year mortality of elderly inpatients with delirium, dementia, or depression seen by a consultation-liaison service. Tsai MC, Weng HH, Chou SY, Tsai CS, Hung TH, Su JA Psychosomatics 2012

Age Factors, Aged, Aged, 80 and over, Delirium, mortality, Dementia, mortality, Depressive Disorder, mortality, Female, Humans, Length of Stay, statistics & numerical data, Logistic Models, Male, Referral and Consultation, Risk Factors, Sex Factors

Risk factors for delirium in patients undergoing hematopoietic stem cell transplantation. Weckmann MT, Gingrich R, Mills JA, Hook L, Beglinger LJ Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 2012

Adult, Aged, Anemia, complications, Anoxia, complications, Blood Urea Nitrogen, Creatinine, blood, Dehydration, complications, Delirium, epidemiology, Erythrocyte Indices, Female, Hematopoietic Stem Cell Transplantation, adverse effects, Hemoglobins, analysis, Humans, Male, Middle Aged, Neoplasms, therapy, Prospective Studies, Risk Factors, Serum Albumin, analysis

What are the opportunities for EEG-based monitoring of delirium in the ICU? van der Kooi AW, Leijten FS, van der Wekken RJ, Slooter AJ The Journal of neuropsychiatry and clinical neurosciences 2012

Cerebral Cortex, physiopathology, Delirium, diagnosis, Electroencephalography, Humans, Intensive Care, Intensive Care Units

Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium. Seymour CW, Pandharipande PP, Koestner T, Hudson LD, Thompson JL, Shintani AK, Ely EW, Girard TD Critical care medicine 2012

Aged, Benzodiazepines, administration & dosage, Circadian Rhythm, Clinical Protocols, Coma, chemically induced, Delirium, chemically induced, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Humans, Hypnotics and Sedatives, administration & dosage, Intensive Care, statistics & numerical data, Male, Middle Aged, Propofol, administration & dosage, Prospective Studies, Respiration, Artificial, methods, Ventilator Weaning, statistics & numerical data

Delirium in postoperative nonventilated intensive care patients: risk factors and outcomes. Serafim RB, Dutra MF, Saddy F, Tura B, de Castro JE, Villarinho LC, da Gloria Santos M, Bozza FA, Rocco JR Annals of intensive care 2012

Delirium

Postoperative

Surgery

Confusion assessment method

Overview of significant changes in the Minimum Data Set for nursing homes version 3.0. Saliba D, Jones M, Streim J, Ouslander J, Berlowitz D, Buchanan J Journal of the American Medical Directors Association 2012

Aged, Data Collection, methods, Geriatric Assessment, methods, Humans, Medicare, Nursing Homes, Patient Admission, standards, United States, United States Department of Veterans Affairs, standards

Effectiveness of acute geriatric unit care using acute care for elders components: a systematic review and meta-analysis. Fox MT, Persaud M, Maimets I, O'Brien K, Brooks D, Tregunno D, Schraa E Journal of the American Geriatrics Society 2012

Accidental Falls, statistics & numerical data, Activities of Daily Living, Aged, Aged, 80 and over, Female, Geriatrics, Hospital Mortality, Hospital Units, economics, Humans, Length of Stay, Male, Patient Discharge, Patient Readmission, statistics & numerical data, Patient-Centered Care, statistics & numerical data, Pressure Ulcer, epidemiology, Quality of Health Care

An evaluation of a proactive geriatric trauma consultation service. Lenartowicz M, Parkovnick M, McFarlan A, Haas B, Straus SE, Nathens AB, Wong CL Annals of surgery 2012

Aged, Female, Health Services for the Aged, Humans, Male, Models, Theoretical, Retrospective Studies, Trauma Centers, Wounds and Injuries, therapy

Obstructive sleep apnea and delirium: exploring possible mechanisms. Mirrakhimov AE, Brewbaker CL, Krystal AD, Kwatra MM Sleep & breathing = Schlaf & Atmung 2014
Effects of hospitalist-directed interdisciplinary medicine floor service on hospital outcomes for seniors with acute medical illness. Yoo JW, Seol H, Kim SJ, Yang JM, Ryu WS, Min TD, Choi JB, Kwon M, Kim S Geriatrics & gerontology international 2014
Oropharyngeal dysphagia in an elderly post-operative hip fracture population: a prospective cohort study. Love AL, Cornwell PL, Whitehouse SL Age and ageing 2013

Age Factors, Aged, Aged, 80 and over, Comorbidity, Deglutition, Deglutition Disorders, diagnosis, Delirium, epidemiology, Fracture Fixation, adverse effects, Hip Fractures, epidemiology, Homes for the Aged, Humans, Incidence, Length of Stay, Logistic Models, Multivariate Analysis, Prospective Studies, Queensland, epidemiology, Risk Factors, Time Factors, Treatment Outcome

Melatonin deficiency hypothesis in delirium: a synthesis of current evidence. de Rooij SE, van Munster BC Rejuvenation research 2013

Animals, Circadian Rhythm, Delirium, metabolism, Humans, Melatonin, deficiency, Models, Biological, Risk Factors

Pathophysiology of encephalopathy and delirium. Williams ST Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 2013

Brain Diseases, physiopathology, Delirium, physiopathology, Humans

Bedside coaching to improve nurses' recognition of delirium. Gordon SJ, Melillo KD, Nannini A, Lakatos BE The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 2013

Adult, Delirium, diagnosis, Education, Nursing, Continuing, methods, Evidence-Based Nursing, methods, Health Knowledge, Attitudes, Practice, Humans, Male, Middle Aged, Nursing Assessment, methods, Nursing Staff, Hospital, education, Questionnaires, Retrospective Studies, Risk Factors, Staff Development, methods, Young Adult

Delirium: past, present, and future. Field RR, Wall MH Seminars in cardiothoracic and vascular anesthesia 2013

Delirium, diagnosis, Humans, Postoperative Complications, etiology, Respiration, Artificial

Incidence and risk factors for postoperative delirium after lumbar spine surgery. Fineberg SJ, Nandyala SV, Marquez-Lara A, Oglesby M, Patel AA, Singh K Spine 2013

Adolescent, Adult, Age Factors, Aged, Comorbidity, Decompression, Surgical, adverse effects, Delirium, epidemiology, Female, Hospital Costs, Humans, Incidence, Inpatients, statistics & numerical data, Logistic Models, Lumbar Vertebrae, surgery, Male, Middle Aged, Nervous System Diseases, epidemiology, Postoperative Complications, epidemiology, Retrospective Studies, Risk Factors, Spinal Fusion, adverse effects, Substance-Related Disorders, epidemiology, Survival Rate, United States, epidemiology, Young Adult

The triple challenge of recruiting older adults with dementia and high medical acuity in skilled nursing facilities. Kolanowski A, Mulhall P, Yevchak A, Hill N, Fick D Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing / Sigma Theta Tau 2013

Aged, Aged, 80 and over, Delirium, complications, Dementia, complications, Female, Humans, Male, Nursing Research, organization & administration, Patient Selection, Skilled Nursing Facilities

Medications, delirium, and older adults. Bell L American journal of critical care : an official publication, American Association of Critical-Care Nurses 2013

Aged, Aged, 80 and over, Delirium, diagnosis, Humans, Practice Guidelines as Topic, Risk Factors

Surgery in elderly people: preoperative, operative and postoperative care to assist healing. Hughes S, Leary A, Zweizig S, Cain J Best practice & research. Clinical obstetrics & gynaecology 2013

Aged, Aging, Delirium, prevention & control, Female, Humans, Pain Management, methods, Pain, Postoperative, therapy, Patient Discharge, Patient Positioning, Postoperative Care, methods, Preoperative Care, methods, Recovery of Function, physiology, Risk Factors, Surgical Procedures, Operative, rehabilitation, Venous Thromboembolism, prevention & control, Wound Healing

Delirium in older people after proximal femoral fracture repair: role of a preoperative screening cognitive test. Mézière A, Paillaud E, Belmin J, Pariel S, Herbaud S, Canouï-Poitrine F, Le Thuaut A, Marty J, Plaud B Annales françaises d'anesthèsie et de rèanimation 2013

Aged, Aged, 80 and over, Cohort Studies, Comorbidity, Delirium, epidemiology, Depression, complications, Educational Status, Female, Femoral Fractures, surgery, Humans, Male, Mental Recall, physiology, Neuropsychological Tests, Orthopedic Procedures, Postoperative Complications, epidemiology, Preoperative Period, Prospective Studies, Risk Factors

Management of acute confusion in patients with CNS infections. Matata C, Defres S, Jones C, Gummery A, Solomon T Nursing standard (Royal College of Nursing (Great Britain) : 1987) 2013

Acute Disease, nursing, Adult, Aggression, Central Nervous System Infections, complications, Confusion, etiology, Curriculum, Delirium, etiology, Female, Great Britain, Humans, Male, Middle Aged, Nursing Staff, Hospital, education, Practice Guidelines as Topic, Risk Factors

Identification and rates of delirium in elderly medical inpatients from diverse language groups. Wand AP, Thoo W, Ting V, Baker J, Sciuriaga H, Hunt GE Geriatric nursing (New York, N.Y.) 2013

Aged, Aged, 80 and over, Delirium, epidemiology, Female, Humans, Inpatients, Language, Male

The aging brain and anesthesia. Brown EN, Purdon PL Current opinion in anaesthesiology 2013

Aged, Aging, pathology, Anesthesia, methods, Animals, Brain, pathology, Electroencephalography, Humans, Mild Cognitive Impairment, physiopathology, Oxidative Stress

Apolipoprotein E ε4 is superior to apolipoprotein E ε2 in predicting cognitive scores over 30 months. Regal P, Nair B, Hetherington E Clinical interventions in aging 2013

Aged, Aged, 80 and over, Apolipoprotein E2, genetics, Apolipoprotein E4, genetics, Cognition Disorders, diagnosis, Cohort Studies, Female, Genetic Markers, Humans, Male, Neuropsychological Tests, New South Wales, Predictive Value of Tests, Prospective Studies, Sex Distribution

Army anesthesia providers' perceptions of emergence delirium after general anesthesia in service members. Wilson JT AANA journal 2013

Anesthesia Recovery Period, Anesthesia, General, adverse effects, Anesthesiology, Delirium, epidemiology, Female, Health Care Surveys, Humans, Male, Military Nursing, Military Personnel, statistics & numerical data, Nurse Anesthetists, Perception, Questionnaires

Incidence of cholinesterase inhibitor therapy initiation among hospitalized patients. Swan JT, Wagle KC, Thompson-Moore N, Taffet GE Journal of hospital medicine : an official publication of the Society of Hospital Medicine 2013

Aged, Aged, 80 and over, Cholinesterase Inhibitors, adverse effects, Cross-Sectional Studies, Delirium, drug therapy, Female, Hospital Mortality, trends, Hospitalization, trends, Humans, Incidence, Male, Retrospective Studies

Assessment of people with cognitive impairment and hip fracture: a systematic review and meta-analysis. Smith T, Hameed Y, Cross J, Sahota O, Fox C Archives of gerontology and geriatrics 2013

Aged, Aged, 80 and over, Cognition Disorders, complications, Delirium, complications, Female, Geriatric Assessment, methods, Hip Fractures, complications, Humans, Male, Neuropsychological Tests, Pain Measurement

Atypical antipsychotics in the treatment of delirium. Wang HR, Woo YS, Bahk WM Psychiatry and clinical neurosciences 2013

Antipsychotic Agents, adverse effects, Benzodiazepines, therapeutic use, Delirium, drug therapy, Dibenzothiazepines, therapeutic use, Humans, Piperazines, therapeutic use, Randomized Controlled Trials as Topic, Risperidone, therapeutic use, Sulpiride, analogs & derivatives, Thiazoles, therapeutic use

The delirium experience: what is the effect on patients, relatives and staff and what can be done to modify this? Partridge JS, Martin FC, Harari D, Dhesi JK International journal of geriatric psychiatry 2013

Anxiety, etiology, Delirium, psychology, Depression, etiology, Family, psychology, Health Personnel, psychology, Humans, Mental Recall, Qualitative Research, Stress Disorders, Post-Traumatic, etiology, Stress, Psychological, etiology

Development of an amygdalocentric neurocircuitry-reactive aggression theoretical model of emergence delirium in posttraumatic stress disorder: an integrative literature review. McLott J, Jurecic J, Hemphill L, Dunn KS AANA journal 2013

Amygdala, physiopathology, Anesthesia, General, adverse effects, Combat Disorders, complications, Delirium, chemically induced, Humans, Nurse Anesthetists, Postoperative Complications, chemically induced, Stress Disorders, Post-Traumatic, complications

Quetiapine for the treatment of delirium. Hawkins SB, Bucklin M, Muzyk AJ Journal of hospital medicine : an official publication of the Society of Hospital Medicine 2013

Antipsychotic Agents, therapeutic use, Delirium, drug therapy, Dibenzothiazepines, therapeutic use, Humans, Randomized Controlled Trials as Topic, methods, Retrospective Studies, Treatment Outcome

Delirium after cardiac surgery: have we overlooked obstructive sleep apnea? Mirrakhimov AE, Yen T, Kwatra MM Medical hypotheses 2013

Delirium, etiology, Humans, Models, Theoretical, Risk Factors, Sleep Apnea, Obstructive, complications, Thoracic Surgical Procedures, adverse effects

Melatonin: delirium (postsurgical). Generali JA, Cada DJ Hospital pharmacy 2013
Delirium: ramelton. Generali JA, Cada DJ Hospital pharmacy 2013
Prophylactic antipsychotic use for postoperative delirium: a systematic review and meta-analysis. Hirota T, Kishi T The Journal of clinical psychiatry 2013

Antipsychotic Agents, classification, Chemoprevention, Comparative Effectiveness Research, Delirium, diagnosis, Humans, Patient Selection, Postoperative Complications, diagnosis, Psychiatric Status Rating Scales, Randomized Controlled Trials as Topic, Risk Assessment, Therapeutic Equivalency

Slower walking speed forecasts increased postoperative morbidity and 1-year mortality across surgical specialties. Robinson TN, Wu DS, Sauaia A, Dunn CL, Stevens-Lapsley JE, Moss M, Stiegmann GV, Gajdos C, Cleveland JC, Inouye SK Annals of surgery 2013

Aged, Aged, 80 and over, Cardiac Surgical Procedures, mortality, Decision Support Techniques, Digestive System Surgical Procedures, mortality, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Male, Postoperative Complications, diagnosis, Preoperative Care, Prognosis, Prospective Studies, ROC Curve, Risk Assessment, Risk Factors, Surgical Procedures, Elective, mortality, Walking, physiology

Progression of delirium in advanced illness: a multivariate model of caregiver and clinician perspectives. Kerr CW, Donnelly JP, Wright ST, Luczkiewicz DL, McKenzie KJ, Hang PC, Kuszczak SM Journal of palliative medicine 2013

Aged, Aged, 80 and over, Attitude of Health Personnel, Caregivers, psychology, Confusion, Delirium, diagnosis, Disease Progression, Female, Hospice Care, Humans, Interviews as Topic, Male, Middle Aged, Multivariate Analysis, Observation, Palliative Care, manpower, Psychomotor Agitation, Qualitative Research, Sleep Disorders, Symptom Assessment, Terminally Ill, psychology

Complex assessment of the incidence and risk factors of delirium in a large cohort of cardiac surgery patients: a single-center 6-year experience. Krzych LJ, Wybraniec MT, Krupka-Matuszczyk I, Skrzypek M, Bolkowska A, Wilczyński M, Bochenek AA BioMed research international 2013

Aged, Aged, 80 and over, Brain Ischemia, complications, Cardiac Surgical Procedures, adverse effects, Delirium, etiology, Female, Humans, Male, Postoperative Complications, etiology, Psychotropic Drugs, Risk Factors, Stroke, complications

An intermediate care unit for older people with both physical and psychiatric disorders: naturalistic outcome study. Hilton C, Madaras A, Qureshi M International psychogeriatrics / IPA 2013

Activities of Daily Living, Aged, Aged, 80 and over, Delirium, psychology, Disabled Persons, psychology, Female, Humans, Intermediate Care Facilities, Length of Stay, statistics & numerical data, Logistic Models, Male, Outcome Assessment (Health Care), Patient Discharge, statistics & numerical data, Retrospective Studies

Use of a Geriatric Quality Initiative to Educate Internal Medicine Residents about Delirium and Its Risk Factors. Olveczky D, Mattison ML, Mukamal KJ Journal of graduate medical education 2013
Quality improvement and cost savings with multicomponent delirium interventions: replication of the Hospital Elder Life Program in a community hospital. Zaubler TS, Murphy K, Rizzuto L, Santos R, Skotzko C, Giordano J, Bustami R, Inouye SK Psychosomatics 2013

Aged, Aged, 80 and over, Chi-Square Distribution, Cost Savings, economics, Delirium, economics, Female, Geriatric Assessment, Health Services for the Aged, economics, Hospital Costs, statistics & numerical data, Hospitals, Community, Humans, Length of Stay, economics, Male, Outcome and Process Assessment (Health Care), statistics & numerical data, Program Evaluation, Quality Improvement, Statistics, Nonparametric

Hospital elder life program integrated in dutch hospital care: a pilot. Bakker FC, Persoon A, Schoon Y, Olde Rikkert MG Journal of the American Geriatrics Society 2013

Aged, Delivery of Health Care, Integrated, methods, Feasibility Studies, Geriatric Assessment, methods, Health Services Needs and Demand, statistics & numerical data, Health Services for the Aged, organization & administration, Home Care Services, organization & administration, Hospitalization, statistics & numerical data, Humans, Middle Aged, Netherlands, Pilot Projects

Learning from the closure of clinical programs: a case series from the Hospital Elder Life Program. SteelFisher GK, Martin LA, Dowal SL, Inouye SK Journal of the American Geriatrics Society 2013

Aged, Cost-Benefit Analysis, Geriatrics, organization & administration, Health Services for the Aged, organization & administration, Hospital Administration, Humans, Organizational Objectives, Program Evaluation, methods, Quality of Health Care, United States

Design and methods of the Hospital Elder Life Program (HELP), a multicomponent targeted intervention to prevent delirium in hospitalized older patients: efficacy and cost-effectiveness in Dutch health care. Strijbos MJ, Steunenberg B, van der Mast RC, Inouye SK, Schuurmans MJ BMC geriatrics 2013

Aged, Aged, 80 and over, Cost-Benefit Analysis, economics, Delirium, economics, Delivery of Health Care, economics, Early Medical Intervention, economics, Female, Hospitalization, economics, Humans, Male, Netherlands, epidemiology, Treatment Outcome

Prediction of delirium after cardiac surgery and the use of a risk checklist. Koster S, Hensens AG, Schuurmans MJ, van der Palen J European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology 2013

Aged, Aged, 80 and over, Cardiac Surgical Procedures, adverse effects, Checklist, Cohort Studies, Delirium, diagnosis, Depressive Disorder, complications, Female, Heart Diseases, complications, Humans, Internal-External Control, Male, Middle Aged, Predictive Value of Tests, Risk Factors, Somatoform Disorders, complications, Stress, Psychological, complications, Surgical Procedures, Elective, adverse effects

Symptoms of delirium predict incident delirium in older long-term care residents. Cole MG, McCusker J, Voyer P, Monette J, Champoux N, Ciampi A, Vu M, Dyachenko A, Belzile E International psychogeriatrics / IPA 2013

Aged, Aged, 80 and over, Canada, epidemiology, Confusion, complications, Delirium, epidemiology, Dementia, complications, Female, Follow-Up Studies, Geriatric Assessment, statistics & numerical data, Humans, Incidence, Long-Term Care, Male, Predictive Value of Tests, Proportional Hazards Models, Prospective Studies, Residential Facilities, Risk Factors

Factors associated with onset of delirium among internal medicine inpatients in Spain. Díez-Manglano J, Palazón-Fraile C, Diez-Massó F, Martínez-Álvarez R, Del Corral-Beamonte E, Carreño-Borrego P, Pueyo-Tejedor P, Gomes-Martín J Nursing research 2013

Age Factors, Aged, Aged, 80 and over, Delirium, epidemiology, Female, Hospital Units, Hospitalization, statistics & numerical data, Humans, Incidence, Internal Medicine, Male, Middle Aged, Retrospective Studies, Risk Factors, Spain, Urinary Catheterization

Evaluation of the prevalence and risk factors of delirium in cardiac surgery ICU. Shadvar K, Baastani F, Mahmoodpoor A, Bilehjani E Journal of cardiovascular and thoracic research 2013
Delirium prevalence, incidence, and implications for screening in specialist palliative care inpatient settings: a systematic review. Hosie A, Davidson PM, Agar M, Sanderson CR, Phillips J Palliative medicine 2013

Delirium, diagnosis, Humans, Incidence, Mass Screening, standards, Palliative Care, methods, Prevalence, Prospective Studies

Test accuracy of short screening tests for diagnosis of delirium or cognitive impairment in an acute stroke unit setting. Lees R, Corbet S, Johnston C, Moffitt E, Shaw G, Quinn TJ Stroke; a journal of cerebral circulation 2013

Aged, Aged, 80 and over, Cognition Disorders, complications, Delirium, complications, Female, Glasgow Coma Scale, Hospital Units, Humans, Male, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Questionnaires, Reproducibility of Results, Sensitivity and Specificity, Stroke, complications

Subsyndromal delirium and its determinants in elderly patients hospitalized for acute medical illness. Zuliani G, Bonetti F, Magon S, Prandini S, Sioulis F, D'Amato M, Zampi E, Gasperini B, Cherubini A The journals of gerontology. Series A, Biological sciences and medical sciences 2013

Acute Disease, Aged, Aged, 80 and over, Aging, blood, Case-Control Studies, Cognition, Delirium, blood, Female, Hospitalization, Humans, Italy, epidemiology, Male, Mental Status Schedule, Oxygen, blood, Prevalence, Risk Factors

Thirty-day prevalence of delirium among very old people: a population-based study of very old people living at home and in institutions. Mathillas J, Olofsson B, Lövheim H, Gustafson Y Archives of gerontology and geriatrics 2013

Age Factors, Aged, 80 and over, psychology, Delirium, epidemiology, Dementia, epidemiology, Depression, epidemiology, Female, Finland, epidemiology, Health Status, Homes for the Aged, statistics & numerical data, Humans, Independent Living, psychology, Institutionalization, statistics & numerical data, Male, Neuropsychological Tests, Prevalence, Sweden, epidemiology

Association between leptin and delirium in elderly inpatients. Sánchez JC, Ospina JP, González MI Neuropsychiatric disease and treatment 2013
Efficacy and safety of haloperidol versus atypical antipsychotic medications in the treatment of delirium. Yoon HJ, Park KM, Choi WJ, Choi SH, Park JY, Kim JJ, Seok JH BMC psychiatry 2013

Aged, Antipsychotic Agents, adverse effects, Benzodiazepines, adverse effects, Delirium, drug therapy, Dibenzothiazepines, adverse effects, Female, Haloperidol, adverse effects, Humans, Male, Middle Aged, Prospective Studies, Risperidone, adverse effects, Treatment Outcome

Association between sedating medications and delirium in older inpatients. Rothberg MB, Herzig SJ, Pekow PS, Avrunin J, Lagu T, Lindenauer PK Journal of the American Geriatrics Society 2013

Aged, Aged, 80 and over, Antipsychotic Agents, therapeutic use, Delirium, chemically induced, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Hypnotics and Sedatives, adverse effects, Inpatients, Male, Prevalence, Psychotic Disorders, drug therapy, Retrospective Studies, Risk Factors, United States, epidemiology

Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. Page VJ, Ely EW, Gates S, Zhao XB, Alce T, Shintani A, Jackson J, Perkins GD, McAuley DF The Lancet. Respiratory medicine 2013
Educational interventions to improve recognition of delirium: a systematic review. Yanamadala M, Wieland D, Heflin MT Journal of the American Geriatrics Society 2013

Aged, Delirium, diagnosis, Health Personnel, education, Humans

Temperature variability during delirium in ICU patients: an observational study. van der Kooi AW, Kappen TH, Raijmakers RJ, Zaal IJ, Slooter AJ PloS one 2013
Automatic delirium prediction system in a Korean surgical intensive care unit. Oh SH, Park EJ, Jin Y, Piao J, Lee SM Nursing in critical care 2014