Delirium Bibliography

Delirium Bibliography books graphicWhat is the Delirium Bibliography? The searchable Delirium Bibliography page is one of our most popular features, allowing you to quickly gain access to the literature on delirium and acute care of older persons. It is primarily intended for clinicians and researchers interested in exploring these topics. The NIDUS team keeps it updated for you on a monthly basis!

How to Search for Articles: Search by author, title, year, and/or keywords. Each article is indexed by keywords taken from MEDLINE and other relevant databases. Click on the title of the article to read the abstract, journal, etc.

Reference Information

Title
Common molecular and pathophysiological underpinnings of delirium and Alzheimer's disease: molecular signatures and therapeutic indications
Authors
Mosharaf, M. P. Alam, K. Gow, J. Mahumud, R. A. Mollah, M. N. H.
Year
2024
Journal
BMC Geriatr
Abstract

BACKGROUND: Delirium and Alzheimer’s disease (AD) are common causes of cognitive dysfunction among older adults. These neurodegenerative diseases share a common and complex relationship, and can occur individually or concurrently, increasing the chance of permanent mental dysfunction. However, the common molecular pathophysiology, key proteomic biomarkers, and functional pathways are largely unknown, whereby delirium is superimposed on AD and dementia. METHODS: We employed an integrated bioinformatics and system biology analysis approach to decipher such common key proteomic signatures, pathophysiological links between delirium and AD by analyzing the gene expression data of AD-affected human brain samples and comparing them with delirium-associated proteins. The present study identified the common drug target hub-proteins examining the protein-protein interaction (PPI) and gene regulatory network analysis. The functional enrichment and pathway analysis was conducted to reveal the common pathophysiological relationship. Finally, the molecular docking and dynamic simulation was used to computationally identify and validate the potential drug target and repurposable drugs for delirium and AD. RESULTS: We detected 99 shared differentially expressed genes (sDEGs) associated with AD and delirium. The sDEGs-set enrichment analysis detected the transmission across chemical synapses, neurodegeneration pathways, neuroinflammation and glutamatergic signaling pathway, oxidative stress, and BDNF signaling pathway as the most significant signaling pathways shared by delirium and AD. The disease-sDEGs interaction analysis highlighted the other disease risk factors with delirium and AD development and progression. Among the sDEGs of delirium and AD, the top 10 hub-proteins including ALB, APP, BDNF, CREB1, DLG4, GAD1, GAD2, GFAP, GRIN2B and GRIN2A were found by the PPI network analysis. Based on the maximum molecular docking binding affinities and molecular dynamic simulation (100 ns) results, the ALB and GAD2 were found as prominent drug target proteins when tacrine and donepezil were identified as potential drug candidates for delirium and AD. CONCLUSION: The study outlined the common key biomolecules and biological pathways shared by delirium and AD. The computationally reported potential drug molecules need a deeper investigation including clinical trials to validate their effectiveness. The outcomes from this study will help to understand the typical pathophysiological relationship between delirium and AD and flag future therapeutic development research for delirium.

PMID

PMID: 39210294

PMICD: PMC11363673

Keywords

Humans
*Alzheimer Disease/genetics/metabolism
*Delirium
Molecular Docking Simulation/methods
Aged
Computational Biology/methods
Protein Interaction Maps/physiology
Proteomics/methods
Biomarkers
Alzheimer’s disease
Common signaling pathways
Delirium
Drug repurposing
Essential drug targets
Molecular docking simulation

Page(s)
Issue

Search:
Total Records Found: 6289, showing 100 per page
TitleAuthorsJournalYearKeywords
Validation of a medical record-based delirium risk assessment. Rudolph JL, Harrington MB, Lucatorto MA, Chester JG, Francis J, Shay KJ, Journal of the American Geriatrics Society 2011

Aged, Aged, 80 and over, Delirium, diagnosis, Female, Humans, Male, Medical Records, Prospective Studies, Risk Assessment

The relationship of neuropsychological function to instrumental activities of daily living in mild cognitive impairment. Reppermund S, Sachdev PS, Crawford J, Kochan NA, Slavin MJ, Kang K, Trollor JN, Draper B, Brodaty H International journal of geriatric psychiatry 2011

Activities of Daily Living, Aged, Aged, 80 and over, Aging, physiology, Analysis of Variance, Cognition Disorders, physiopathology, Factor Analysis, Statistical, Female, Humans, Male, Neuropsychological Tests

Standardised frailty indicator as predictor for postoperative delirium after vascular surgery: a prospective cohort study. Pol RA, van Leeuwen BL, Visser L, Izaks GJ, van den Dungen JJ, Tielliu IF, Zeebregts CJ European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2011

Activities of Daily Living, classification, Adult, Aged, Aged, 80 and over, Cohort Studies, Delirium, etiology, Female, Frail Elderly, Geriatric Assessment, Humans, Intensive Care Units, Length of Stay, Male, Middle Aged, Patient Admission, Postoperative Complications, etiology, Prospective Studies, Risk Factors, Vascular Diseases, surgery, Young Adult

Detecting deficits of sustained visual attention in delirium. Brown LJ, Fordyce C, Zaghdani H, Starr JM, MacLullich AM Journal of neurology, neurosurgery, and psychiatry 2011

Aged, Aged, 80 and over, Attention, Case-Control Studies, Delirium, diagnosis, Dementia, diagnosis, Diagnosis, Differential, Female, Geriatric Assessment, methods, Humans, Male, Neuropsychological Tests, statistics & numerical data, Psychiatric Status Rating Scales, Psychomotor Performance, Visual Perception

The neuropsychological course of acute delirium in adult hematopoietic stem cell transplantation patients. Beglinger LJ, Mills JA, Vik SM, Duff K, Denburg NL, Weckmann MT, Paulsen JS, Gingrich R Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists 2011

Adult, Aged, Attention, Bone Marrow Transplantation, psychology, Cognition Disorders, complications, Delirium, complications, Female, Hematopoietic Stem Cell Transplantation, psychology, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, statistics & numerical data, Psychomotor Performance

The Montreal Cognitive Assessment and the mini-mental state examination as screening instruments for cognitive impairment: item analyses and threshold scores. Damian AM, Jacobson SA, Hentz JG, Belden CM, Shill HA, Sabbagh MN, Caviness JN, Adler CH Dementia and geriatric cognitive disorders 2011

Aged, Alzheimer Disease, psychology, Cognition, physiology, Cognition Disorders, diagnosis, Dementia, etiology, Dementia, Vascular, psychology, Female, Humans, Lewy Body Disease, psychology, Longitudinal Studies, Male, Neurologic Examination, Neuropsychological Tests, Parkinson Disease, complications, ROC Curve, Reference Values

Urinary tract infection in very old women is associated with delirium. Eriksson I, Gustafson Y, Fagerström L, Olofsson B International psychogeriatrics / IPA 2011

Activities of Daily Living, psychology, Aged, 80 and over, Chi-Square Distribution, Delirium, etiology, Female, Humans, Logistic Models, Neuropsychological Tests, Urinary Tract Infections, complications

Computerized decision support for delirium superimposed on dementia in older adults. Fick DM, Steis MR, Mion LC, Walls JL Journal of gerontological nursing 2011

Aged, Aged, 80 and over, Computers, Decision Support Systems, Clinical, Delirium, complications, Dementia, complications, Feasibility Studies, Humans, Nursing Diagnosis, Pilot Projects

Delirium is an important predictor of incident dementia among elderly hip fracture patients. Krogseth M, Wyller TB, Engedal K, Juliebø V Dementia and geriatric cognitive disorders 2011

Aged, Aged, 80 and over, Caregivers, Cognition Disorders, epidemiology, Delirium, epidemiology, Dementia, epidemiology, Diagnostic and Statistical Manual of Mental Disorders, Disease Progression, Female, Follow-Up Studies, Hip Fractures, psychology, Humans, Male, Memory, physiology, Neuropsychological Tests, Odds Ratio, Predictive Value of Tests, Prospective Studies, Regression Analysis, Risk Factors, Stroop Test, Wechsler Scales

Risk factors of stroke and delirium after off-pump coronary artery bypass surgery. Miyazaki S, Yoshitani K, Miura N, Irie T, Inatomi Y, Ohnishi Y, Kobayashi J Interactive cardiovascular and thoracic surgery 2011

Age Factors, Aged, Aged, 80 and over, Atrial Fibrillation, complications, Biological Markers, blood, Carotid Stenosis, complications, Chi-Square Distribution, Coronary Artery Bypass, Off-Pump, adverse effects, Creatinine, blood, Delirium, epidemiology, Diabetes Complications, etiology, Female, Humans, Hypertension, complications, Incidence, Ischemic Attack, Transient, epidemiology, Japan, epidemiology, Logistic Models, Male, Middle Aged, Retrospective Studies, Risk Assessment, Risk Factors, Smoking, adverse effects, Stroke, epidemiology, Ultrasonography, Doppler, Duplex

Anesthesia and postoperative delirium in older adults undergoing hip surgery. Slor CJ, de Jonghe JF, Vreeswijk R, Groot E, Ploeg TV, van Gool WA, Eikelenboom P, Snoeck M, Schmand B, Kalisvaart KJ Journal of the American Geriatrics Society 2011

Aged, Anesthesia, Conduction, adverse effects, Anesthesia, General, adverse effects, Cognition Disorders, complications, Delirium, chemically induced, Female, Haloperidol, therapeutic use, Hip, surgery, Humans, Logistic Models, Male, Perioperative Care, Postoperative Complications, prevention & control, Risk Factors

Routine use of the confusion assessment method for the intensive care unit: a multicenter study. van Eijk MM, van den Boogaard M, van Marum RJ, Benner P, Eikelenboom P, Honing ML, van der Hoven B, Horn J, Izaks GJ, Kalf A, Karakus A, Klijn IA, Kuiper MA, de Leeuw FE, de Man T, van der Mast RC, Osse RJ, de Rooij SE, Spronk PE, van der Voort PH, van Go American journal of respiratory and critical care medicine 2011

APACHE, Critical Care, methods, Delirium, diagnosis, Female, Humans, Intensive Care Units, standards, Male, Mass Screening, methods, Middle Aged, Netherlands, Sensitivity and Specificity

Postoperative delirium after colorectal surgery in older patients. Mangnall LT, Gallagher R, Stein-Parbury J American journal of critical care : an official publication, American Association of Critical-Care Nurses 2011

Aged, Aged, 80 and over, Colorectal Surgery, Delirium, diagnosis, Female, Humans, Male, Mental Status Schedule, Middle Aged, New South Wales, epidemiology, Postoperative Complications, psychology, Prospective Studies, Regression Analysis

Assessing severity of delirium by the Delirium Observation Screening Scale. Scheffer AC, van Munster BC, Schuurmans MJ, de Rooij SE International journal of geriatric psychiatry 2011

Aged, Aged, 80 and over, Delirium, diagnosis, Female, Geriatric Assessment, Humans, Male, Mass Screening, methods, Neuropsychological Tests, standards, Psychiatric Status Rating Scales, Reproducibility of Results, Sensitivity and Specificity, Severity of Illness Index

Delirium in the acute phase after stroke: incidence, risk factors, and outcome. Oldenbeuving AW, de Kort PL, Jansen BP, Algra A, Kappelle LJ, Roks G Neurology 2011

Adult, Aged, Aged, 80 and over, Atrophy, pathology, Brain, pathology, Delirium, diagnosis, Female, Humans, Incidence, Male, Middle Aged, Odds Ratio, Questionnaires, Recovery of Function, Risk Factors, Severity of Illness Index, Stroke, complications

Evaluation of two intensive care delirium screening tools for non-critically ill hospitalized patients. Neufeld KJ, Hayat MJ, Coughlin JM, Huberman AL, Leistikow NA, Krumm SK, Needham DM Psychosomatics 2011

Aged, Confusion, diagnosis, Critical Illness, Delirium, diagnosis, Female, Humans, Intensive Care Units, Male, Mass Screening, methods, Middle Aged, Neuropsychological Tests, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors, Sensitivity and Specificity

Prevalence and natural history of neuropsychiatric syndromes in veteran hospice patients. Goy ER, Ganzini L Journal of pain and symptom management 2011

Aged, Aged, 80 and over, Alcoholism, diagnosis, Anxiety, diagnosis, Cognition Disorders, diagnosis, Delirium, diagnosis, Depression, diagnosis, Female, Hospice Care, psychology, Humans, Male, Middle Aged, Neuropsychological Tests, Prevalence, Psychiatric Status Rating Scales, Suicidal Ideation, Veterans, psychology

Motor subtypes of postoperative delirium in older adults. Robinson TN, Raeburn CD, Tran ZV, Brenner LA, Moss M Archives of surgery (Chicago, Ill. : 1960) 2011

Age Factors, Aged, Analysis of Variance, Cohort Studies, Delirium, classification, Female, Geriatric Assessment, Humans, Incidence, Male, Middle Aged, Postoperative Complications, diagnosis, Preoperative Care, methods, Prospective Studies, Psychomotor Agitation, classification, Risk Assessment, Surgical Procedures, Elective, methods, Survival Analysis

The influence of perioperative care and treatment on the 4-month outcome in elderly patients with hip fracture. Björkelund KB, Hommel A, Thorngren KG, Lundberg D, Larsson S AANA journal 2011

Age Distribution, Aged, Aged, 80 and over, Anesthesia, mortality, Female, Hip Fractures, mortality, Humans, Male, Nurse Anesthetists, Perioperative Care, statistics & numerical data, Registries, Retrospective Studies, Risk Factors

Validity of the montreal cognitive assessment (MoCA) as a screening test for mild cognitive impairment (MCI) in a cardiovascular population. McLennan SN, Mathias JL, Brennan LC, Stewart S Journal of geriatric psychiatry and neurology 2011

Aged, Aged, 80 and over, Cardiovascular Diseases, complications, Cognition Disorders, complications, Female, Humans, Male, Mass Screening, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Reproducibility of Results, Sensitivity and Specificity

Diagnosing delirium in elderly Thai patients: utilization of the CAM algorithm. Wongpakaran N, Wongpakaran T, Bookamana P, Pinyopornpanish M, Maneeton B, Lerttrakarnnon P, Uttawichai K, Jiraniramai S BMC family practice 2011

Aged, Aged, 80 and over, Algorithms, Confusion, diagnosis, Delirium, diagnosis, Family Practice, Female, Humans, Male, Middle Aged, Prospective Studies, Psychiatry, Thailand

Patterns of cognitive change in elderly patients during and 6 months after hospitalisation: a prospective cohort study. Chen CC, Chiu MJ, Chen SP, Cheng CM, Huang GH International journal of nursing studies 2011

Aged, Cognition, Female, Hospitalization, Humans, Length of Stay, Male, Prognosis, Prospective Studies

Beyond grand rounds: a comprehensive and sequential intervention to improve identification of delirium. Ramaswamy R, Dix EF, Drew JE, Diamond JJ, Inouye SK, Roehl BJ The Gerontologist 2011

Clinical Medicine, education, Delirium, diagnosis, Education, Medical, Continuing, methods, Educational Measurement, Family Practice, education, Female, Focus Groups, Health Knowledge, Attitudes, Practice, Health Personnel, education, Hospitals, Community, Humans, Male, Program Evaluation, Quality Improvement, Teaching Rounds

Proton Magnetic Resonance Spectroscopy in adult cancer patients with delirium. Yager JR, Magnotta VA, Mills JA, Vik SM, Weckmann MT, Capizzano AA, Gingrich R, Beglinger LJ Psychiatry research 2011

Adult, Aged, Aspartic Acid, analogs & derivatives, Bone Marrow Transplantation, Choline, metabolism, Delirium, complications, Female, Humans, Magnetic Resonance Spectroscopy, Male, Middle Aged, Neoplasms, complications, Protons, diagnostic use, Retrospective Studies, Spectrum Analysis

Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit. Smith HA, Boyd J, Fuchs DC, Melvin K, Berry P, Shintani A, Eden SK, Terrell MK, Boswell T, Wolfram K, Sopfe J, Barr FE, Pandharipande PP, Ely EW Critical care medicine 2011

Child, Child, Preschool, Cohort Studies, Confusion, diagnosis, Critical Care, methods, Critical Illness, Delirium, diagnosis, Female, Humans, Intensive Care Units, Pediatric, Male, Neuropsychiatry, standards, Observer Variation, Practice Guidelines as Topic, Prospective Studies, Psychometrics, Reference Standards, Reproducibility of Results, Risk Assessment, Sensitivity and Specificity, Severity of Illness Index

Falls in older hospital inpatients and the effect of cognitive impairment: a secondary analysis of prevalence studies. Härlein J, Halfens RJ, Dassen T, Lahmann NA Journal of clinical nursing 2011

Accidental Falls, statistics & numerical data, Aged, Cognition Disorders, epidemiology, Female, Hospitalization, Humans, Inpatients, Male, Middle Aged, Prevalence

Glucocorticoid receptor haplotype is associated with a decreased risk of delirium in the elderly. Manenschijn L, van Rossum EF, Jetten AM, de Rooij SE, van Munster BC American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2011

Aged, Aged, 80 and over, Base Sequence, Cognition, physiology, Delirium, genetics, Female, Genetic Predisposition to Disease, Haplotypes, genetics, Humans, Male, Molecular Sequence Data, Odds Ratio, Receptors, Glucocorticoid, genetics, Risk Factors

The effect of nurse-facilitated family participation in the psychological care of the critically ill patient. Black P, Boore JR, Parahoo K Journal of advanced nursing 2011

Adaptation, Psychological, Adolescent, Adult, Aged, Aged, 80 and over, Caregivers, education, Case-Control Studies, Critical Illness, nursing, Delirium, epidemiology, Family, Female, Holistic Nursing, Humans, Intensive Care Units, organization & administration, Length of Stay, statistics & numerical data, Male, Middle Aged, Models, Nursing, Northern Ireland, Nurse’s Role, Nursing Evaluation Research, Severity of Illness Index, Sickness Impact Profile, Treatment Outcome, Young Adult

The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial. de Jonghe A, van Munster BC, van Oosten HE, Goslings JC, Kloen P, van Rees C, Wolvius R, van Velde R, Levi MM, Korevaar JC, de Rooij SE, BMC geriatrics 2011

Aged, Delirium, complications, Double-Blind Method, Female, Follow-Up Studies, Hip Fractures, complications, Humans, Male, Melatonin, therapeutic use, Placebo Effect, Prospective Studies

The clock drawing test is a poor screening tool for postoperative delirium and cognitive dysfunction after aortic repair. Bryson GL, Wyand A, Wozny D, Rees L, Taljaard M, Nathan H Canadian journal of anaesthesia = Journal canadien d'anesthésie 2011

Aged, Aorta, Abdominal, surgery, Cognition Disorders, diagnosis, Cohort Studies, Delirium, diagnosis, Female, Humans, Male, Middle Aged, Postoperative Complications, diagnosis, Prospective Studies

A prospective cohort study evaluating associations among delirium, postoperative cognitive dysfunction, and apolipoprotein E genotype following open aortic repair. Bryson GL, Wyand A, Wozny D, Rees L, Taljaard M, Nathan H Canadian journal of anaesthesia = Journal canadien d'anesthésie 2011

Aged, Aorta, Abdominal, surgery, Apolipoprotein E4, genetics, Cognition Disorders, etiology, Cohort Studies, Delirium, etiology, Female, Genotype, Humans, Logistic Models, Male, Middle Aged, Postoperative Complications, etiology, Prospective Studies, Risk

Four sensitive screening tools to detect cognitive dysfunction in geriatric emergency department patients: brief Alzheimer's Screen, Short Blessed Test, Ottawa 3DY, and the caregiver-completed AD8. Carpenter CR, Bassett ER, Fischer GM, Shirshekan J, Galvin JE, Morris JC Academic emergency medicine : official journal of the Society for Academic Emergency Medicine 2011

Aged, Aged, 80 and over, Caregivers, Cognition Disorders, diagnosis, Cross-Sectional Studies, Emergency Service, Hospital, Female, Geriatric Assessment, methods, Humans, Male, Mass Screening, instrumentation, Mental Status Schedule, Prospective Studies, Sensitivity and Specificity

Modified hospital elder life program: effects on abdominal surgery patients. Chen CC, Lin MT, Tien YW, Yen CJ, Huang GH, Inouye SK Journal of the American College of Surgeons 2011

Abdomen, surgery, Activities of Daily Living, Aged, Cognition, Delirium, etiology, Female, Humans, Male, Nutritional Support, nursing, Postoperative Care, nursing, Postoperative Complications, nursing

Characteristics of patients with brain metastases from lung cancer in a palliative care center. Yamanaka R, Koga H, Yamamoto Y, Yamada S, Sano T, Fukushige T Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2011

Aged, Brain Neoplasms, physiopathology, Female, Humans, Lung Neoplasms, pathology, Male, Middle Aged, Palliative Care, methods, Quality of Life, Retrospective Studies, Time Factors

Neuropsychiatric symptoms during 24 hours after dobutamine-atropine stress testing: a prospective study in 1,006 patients. Wuthiwaropas P, Wiste JA, McCully RB, Kane GC, Scott CG, Pellikka PA Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2011

Aged, Atropine, adverse effects, Cardiotonic Agents, adverse effects, Chi-Square Distribution, Delirium, etiology, Dobutamine, adverse effects, Echocardiography, Stress, adverse effects, Female, Humans, Incidence, Logistic Models, Male, Predictive Value of Tests, Prospective Studies, Questionnaires, Risk Factors

Cerebrospinal fluid β-amyloid and tau are not associated with risk of delirium: a prospective cohort study in older adults with hip fracture. Witlox J, Kalisvaart KJ, de Jonghe JF, Verwey NA, van Stijn MF, Houdijk AP, Traast HS, MacLullich AM, van Gool WA, Eikelenboom P Journal of the American Geriatrics Society 2011

Aged, 80 and over, Amyloid beta-Peptides, cerebrospinal fluid, Cognition Disorders, complications, Cohort Studies, Delirium, cerebrospinal fluid, Female, Hip Fractures, complications, Humans, Male, Peptide Fragments, cerebrospinal fluid, Phosphorylation, Postoperative Complications, Prospective Studies, tau Proteins, cerebrospinal fluid

Factors associated with delirium severity among older persons with dementia. Voyer P, Richard S, Doucet L, Carmichael PH The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 2011

Aged, Aged, 80 and over, Delirium, epidemiology, Dementia, epidemiology, Female, Geriatric Nursing, Humans, Long-Term Care, statistics & numerical data, Male, Morbidity, Risk Factors, Severity of Illness Index

Delirium in acute stroke: a predictor of subsequent cognitive impairment? A two-year follow-up study. van Rijsbergen MW, Oldenbeuving AW, Nieuwenhuis-Mark RE, Nys GM, Las SG, Roks G, de Kort PL Journal of the neurological sciences 2011

Aged, Aged, 80 and over, Attention, physiology, Case-Control Studies, Cognition Disorders, diagnosis, Delirium, complications, Executive Function, physiology, Female, Follow-Up Studies, Humans, Language, Learning, physiology, Male, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Stroke, complications, Visual Perception, physiology

Usefulness of acute delirium as a predictor of adverse outcomes in patients >65 years of age with acute decompensated heart failure. Uthamalingam S, Gurm GS, Daley M, Flynn J, Capodilupo R The American journal of cardiology 2011

Acute Disease, Aged, Aged, 80 and over, Cardiovascular Diseases, diagnosis, Cause of Death, Comorbidity, Delirium, diagnosis, Female, Heart Failure, diagnosis, Hospital Mortality, Humans, Kaplan-Meier Estimate, Male, Patient Readmission, statistics & numerical data, Retrospective Studies, Risk Assessment, Ventricular Dysfunction, Left, diagnosis

The influence of propofol or desflurane on postoperative cognitive dysfunction in patients undergoing coronary artery bypass surgery. Royse CF, Andrews DT, Newman SN, Stygall J, Williams Z, Pang J, Royse AG Anaesthesia 2011

Aged, Anesthetics, Inhalation, pharmacology, Anesthetics, Intravenous, pharmacology, Cognition, drug effects, Cognition Disorders, etiology, Coronary Artery Bypass, adverse effects, Female, Follow-Up Studies, Humans, Isoflurane, analogs & derivatives, Male, Middle Aged, Neuropsychological Tests, Propofol, pharmacology, Risk Factors

Delirium and the functional recovery of older medical inpatients after acute illness: the significance of biological factors. Adamis D, Treloar A, Gregson N, Macdonald AJ, Martin FC Archives of gerontology and geriatrics 2011

Acute Disease, Aged, Aged, 80 and over, Apolipoproteins E, genetics, Cytokines, blood, Delirium, blood, Female, Geriatric Assessment, Humans, Inpatients, Longitudinal Studies, Male, Neuropsychological Tests, Prevalence, Prospective Studies, Recovery of Function

Ease of screening for depression and delirium in patients enrolled in inpatient hospice care. Rao S, Ferris FD, Irwin SA Journal of palliative medicine 2011

Adult, Aged, Aged, 80 and over, California, Delirium, diagnosis, Depression, diagnosis, Female, Hospice Care, Humans, Inpatients, psychology, Male, Mass Screening, methods, Middle Aged, Palliative Care, Terminal Care

Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial. Pesonen A, Suojaranta-Ylinen R, Hammarén E, Kontinen VK, Raivio P, Tarkkila P, Rosenberg PH British journal of anaesthesia 2011

Aged, Aged, 80 and over, Analgesics, Non-Narcotic, administration & dosage, Analgesics, Opioid, administration & dosage, Cardiac Surgical Procedures, Confusion, chemically induced, Drug Administration Schedule, Drug Therapy, Combination, Epidemiologic Methods, Female, Humans, Male, Oxycodone, administration & dosage, Pain Measurement, methods, Pain, Postoperative, prevention & control, Postoperative Care, methods, Postoperative Complications, Postoperative Nausea and Vomiting, chemically induced, gamma-Aminobutyric Acid, administration & dosage

The effect of cognitive impairment on the accuracy of the presenting complaint and discharge instruction comprehension in older emergency department patients. Han JH, Bryce SN, Ely EW, Kripalani S, Morandi A, Shintani A, Jackson JC, Storrow AB, Dittus RS, Schnelle J Annals of emergency medicine 2011

Aged, Aged, 80 and over, Cognition Disorders, complications, Comprehension, Cross-Sectional Studies, Delirium, complications, Dementia, complications, Emergency Service, Hospital, Female, Health Literacy, Humans, Logistic Models, Male, Neuropsychological Tests, Patient Compliance, psychology, Patient Discharge, Severity of Illness Index

Differential effects of delirium on fluid and crystallized cognitive abilities. Brown LJ, Ferner HS, Robertson J, Mills NL, Pessotto R, Deary IJ, MacLullich AM Archives of gerontology and geriatrics 2011

Aged, Aged, 80 and over, Cardiac Surgical Procedures, adverse effects, Cognition Disorders, diagnosis, Delirium, diagnosis, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Postoperative Complications, Reading, Stroop Test

Translation and validation of the Korean Confusion Assessment Method for the Intensive Care Unit. Heo EY, Lee BJ, Hahm BJ, Song EH, Lee HA, Yoo CG, Kim YW, Han SK, Shim YS, Lee SM BMC psychiatry 2011

Adult, Aged, Aged, 80 and over, Asian Continental Ancestry Group, psychology, Delirium, diagnosis, Female, Humans, Intensive Care Units, Male, Middle Aged, Observer Variation, Predictive Value of Tests, Psychiatric Status Rating Scales, statistics & numerical data, Sensitivity and Specificity, Translations

Factors associated with recovery from early postoperative delirium. DeCrane SK, Sands L, Ashland M, Lim E, Tsai TL, Paul S, Leung JM Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses / American Society of PeriAnesthesia Nurses 2011

Aged, Delirium, complications, Female, Humans, Male, Multivariate Analysis, Postoperative Complications

Mortality associated with delirium after hip-surgery: a 2-year follow-up study. Kat MG, de Jonghe JF, Vreeswijk R, van der Ploeg T, van Gool WA, Eikelenboom P, Kalisvaart KJ Age and ageing 2011

Aged, Antipsychotic Agents, therapeutic use, Delirium, complications, Female, Follow-Up Studies, Haloperidol, therapeutic use, Hip, surgery, Hospitalization, statistics & numerical data, Humans, Incidence, Male, Netherlands, epidemiology, Postoperative Complications, mortality, Postoperative Period, Proportional Hazards Models, Prospective Studies, Risk Factors, Survival Rate, Treatment Outcome

Delirium in long-term care setting: indicator to severe morbidity. Arinzon Z, Peisakh A, Schrire S, Berner YN Archives of gerontology and geriatrics 2011

Aged, Aged, 80 and over, Cardiovascular Diseases, complications, Communicable Diseases, complications, Comorbidity, Delirium, diagnosis, Dementia, diagnosis, Female, Geriatric Assessment, Humans, Incidence, Long-Term Care, Male, Neuropsychological Tests, Prevalence, Prospective Studies, Severity of Illness Index

Phenomenological and neuropsychological profile across motor variants of delirium in a palliative-care unit. Leonard M, Donnelly S, Conroy M, Trzepacz P, Meagher DJ The Journal of neuropsychiatry and clinical neurosciences 2011

Aged, Aged, 80 and over, Delirium, diagnosis, Delusions, diagnosis, Female, Hallucinations, diagnosis, Humans, Male, Middle Aged, Neuropsychological Tests, Palliative Care, psychology, Psychiatric Status Rating Scales

Preoperative risk factors for postoperative delirium (POD) after urological surgery in the elderly. Tognoni P, Simonato A, Robutti N, Pisani M, Cataldi A, Monacelli F, Carmignani G, Odetti P Archives of gerontology and geriatrics 2011

Activities of Daily Living, Aged, Aging, Cognition, Cohort Studies, Delirium, epidemiology, Female, Geriatric Assessment, Humans, Hypotension, complications, Male, Postoperative Complications, epidemiology, Risk Factors, Urologic Surgical Procedures

Telephone-based identification of mild cognitive impairment and dementia in a multicultural cohort. Manly JJ, Schupf N, Stern Y, Brickman AM, Tang MX, Mayeux R Archives of neurology 2011

African Americans, statistics & numerical data, Aged, Aged, 80 and over, Algorithms, Cognition, Cognition Disorders, diagnosis, Cohort Studies, Cultural Diversity, Dementia, diagnosis, European Continental Ancestry Group, statistics & numerical data, Female, Hispanic Americans, statistics & numerical data, Humans, Interview, Psychological, Language, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Questionnaires, ROC Curve, Reproducibility of Results, Sensitivity and Specificity, Telephone, United States, epidemiology

Review article: terminal delirium in geriatric patients with cancer at end of life. Moyer DD The American journal of hospice & palliative care 2011

Central Nervous System Stimulants, therapeutic use, Critical Illness, Delirium, diagnosis, Humans, Inpatients, psychology, Neoplasms, complications, Palliative Care, methods, Severity of Illness Index, Terminal Care, methods

Preventing postoperative complications in the elderly. Sieber FE, Barnett SR Anesthesiology clinics 2011

Adrenergic beta-Antagonists, therapeutic use, Aged, physiology, Anesthesia, adverse effects, Case Management, Comorbidity, Delirium, prevention & control, Heart Diseases, prevention & control, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, therapeutic use, Hypnotics and Sedatives, therapeutic use, Lung Diseases, prevention & control, Nervous System Diseases, etiology, Pain, Postoperative, therapy, Postoperative Complications, epidemiology, Quality Control, Quality Improvement, organization & administration, Randomized Controlled Trials as Topic, Risk Factors

The evaluation and management of delirium among older persons. Flaherty JH The Medical clinics of North America 2011

Aged, Aged, 80 and over, Delirium, diagnosis, Dementia, diagnosis, Diagnosis, Differential, Evidence-Based Medicine, Geriatric Assessment, methods, Health Status, Humans, Middle Aged, Patient Care Team, organization & administration, Primary Prevention, methods, Risk Assessment

Review: delirium in the elderly: a comprehensive review. Mittal V, Muralee S, Williamson D, McEnerney N, Thomas J, Cash M, Tampi RR American journal of Alzheimer's disease and other dementias 2011

Aged, Cognition Disorders, diagnosis, Delirium, diagnosis, Diagnosis, Differential, Geriatrics, methods, Humans, Morbidity, Risk Factors

Validation of the Intensive Care Delirium Screening Checklist in nonintubated intensive care unit patients in a resource-poor medical intensive care setting in South India. George C, Nair JS, Ebenezer JA, Gangadharan A, Christudas A, Gnanaseelan LK, Jacob KS Journal of critical care 2011

Adult, Aged, Delirium, diagnosis, Female, Hospitals, Teaching, Humans, India, Intensive Care Units, Internship and Residency, Male, Middle Aged, Observer Variation, Questionnaires, Sensitivity and Specificity

The effects of exercise therapy on delirium in cancer patients: a retrospective study. Tatematsu N, Hayashi A, Narita K, Tamaki A, Tsuboyama T Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2011

Age Factors, Aged, Analgesics, Opioid, administration & dosage, Antipsychotic Agents, administration & dosage, Delirium, etiology, Dose-Response Relationship, Drug, Exercise Therapy, methods, Female, Hospitals, University, Humans, Japan, Male, Middle Aged, Neoplasms, complications, Palliative Care, methods, Retrospective Studies, Risk Factors, Survival Rate

Screening for cognitive impairment in an elderly veteran population: acceptability and results using different versions of the Mini-Cog. McCarten JR, Anderson P, Kuskowski MA, McPherson SE, Borson S Journal of the American Geriatrics Society 2011

Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Dementia, diagnosis, Geriatric Assessment, methods, Humans, Mass Screening, methods, Neuropsychological Tests, Primary Health Care, methods, Retrospective Studies, Veterans

Sustainability and scalability of the hospital elder life program at a community hospital. Rubin FH, Neal K, Fenlon K, Hassan S, Inouye SK Journal of the American Geriatrics Society 2011

Activities of Daily Living, Aged, Delirium, prevention & control, Geriatric Assessment, Hospitals, Community, standards, Humans, Patient Care Planning, organization & administration, Quality Assurance, Health Care, Retrospective Studies

Genetic variations in the interleukin-6 and interleukin-8 genes and the interleukin-6 receptor gene in delirium. van Munster BC, Zwinderman AH, de Rooij SE Rejuvenation research 2011

Aged, Aged, 80 and over, Delirium, genetics, Female, Genetic Variation, Humans, Interleukin-6, genetics, Interleukin-8, genetics, Male, Polymorphism, Genetic, Receptors, Interleukin-6, genetics

Use of nurse-observed symptoms of delirium in long-term care: effects on prevalence and outcomes of delirium. McCusker J, Cole MG, Voyer P, Monette J, Champoux N, Ciampi A, Vu M, Belzile E International psychogeriatrics / IPA 2011

Aged, Aged, 80 and over, Biomedical Research, Delirium, diagnosis, Female, Follow-Up Studies, Humans, Long-Term Care, Male, Nurses, Observation, Prevalence, Prospective Studies

Neuropsychiatric symptoms and the risk of institutionalization and death: the aging, demographics, and memory study. Okura T, Plassman BL, Steffens DC, Llewellyn DJ, Potter GG, Langa KM Journal of the American Geriatrics Society 2011

Activities of Daily Living, Aged, Aged, 80 and over, Behavioral Symptoms, Caregivers, psychology, Cognition Disorders, physiopathology, Female, Humans, Institutionalization, statistics & numerical data, Male, Neuropsychological Tests, Proportional Hazards Models

Cognitive impairment: an independent predictor of excess mortality: a cohort study. Sachs GA, Carter R, Holtz LR, Smith F, Stump TE, Tu W, Callahan CM Annals of internal medicine 2011

Aged, Aged, 80 and over, Cardiovascular Diseases, mortality, Cognition Disorders, Female, Humans, Influenza, Human, mortality, Kaplan-Meier Estimate, Male, Middle Aged, Mortality, Neoplasms, mortality, Pneumonia, mortality, Primary Health Care, Proportional Hazards Models, Questionnaires

Cerebrospinal fluid interleukin-8 levels are higher in people with hip fracture with perioperative delirium than in controls. MacLullich AM, Edelshain BT, Hall RJ, de Vries A, Howie SE, Pearson A, Middleton SD, Gillies F, Armstrong IR, White TO, Cunningham C, de Rooij SE, van Munster BC Journal of the American Geriatrics Society 2011

Aged, Aged, 80 and over, Biological Markers, cerebrospinal fluid, Delirium, cerebrospinal fluid, Female, Hip Fractures, cerebrospinal fluid, Humans, Inflammation Mediators, cerebrospinal fluid, Interleukin-6, cerebrospinal fluid, Interleukin-8, cerebrospinal fluid, Male, Middle Aged, Postoperative Complications, cerebrospinal fluid, Postoperative Period, Reference Values, Tumor Necrosis Factor-alpha, cerebrospinal fluid

High yield research opportunities in geriatric emergency medicine: prehospital care, delirium, adverse drug events, and falls. Carpenter CR, Shah MN, Hustey FM, Heard K, Gerson LW, Miller DK The journals of gerontology. Series A, Biological sciences and medical sciences 2011

Accidental Falls, statistics & numerical data, Aged, Delirium, epidemiology, Drug-Related Side Effects and Adverse Reactions, epidemiology, Emergency Medical Services, methods, Geriatric Assessment, statistics & numerical data, Hospitalization, statistics & numerical data, Humans, Incidence, United States, epidemiology

Brain-derived neurotrophic factor and neuron-specific enolase, but not S100β, levels are associated to the occurrence of delirium in intensive care unit patients. Grandi C, Tomasi CD, Fernandes K, Stertz L, Kapczinski F, Quevedo J, Dal-Pizzol F, Ritter C Journal of critical care 2011

Adult, Aged, Biological Markers, blood, Brain-Derived Neurotrophic Factor, blood, Case-Control Studies, Critical Illness, Delirium, blood, Enzyme-Linked Immunosorbent Assay, Female, Humans, Intensive Care Units, Male, Middle Aged, Nerve Growth Factors, blood, Phosphopyruvate Hydratase, blood, S100 Calcium Binding Protein beta Subunit, S100 Proteins, blood

Twelve-month mortality among delirium subtypes. DeCrane SK, Culp KR, Wakefield B Clinical nursing research 2011

Aged, 80 and over, Cause of Death, trends, Delirium, classification, Female, Follow-Up Studies, Humans, International Classification of Diseases, Iowa, epidemiology, Long-Term Care, Male, Population Surveillance, Rural Health

In the clinic. Delirium. Marcantonio ER Annals of internal medicine 2011

Delirium, diagnosis, Humans, Patient Education as Topic, Practice Guidelines as Topic, Risk Factors

Brainstem responses can predict death and delirium in sedated patients in intensive care unit. Sharshar T, Porcher R, Siami S, Rohaut B, Bailly-Salin J, Hopkinson NS, Clair B, Guidoux C, Iacobone E, Sonneville R, Polito A, Aboab J, Gaudry S, Morla O, Amouyal G, Azuar J, Allary J, Vieillard-Baron A, Wolff M, Cariou A, Annane D, Critical care medicine 2011

Aged, Aged, 80 and over, Cause of Death, Cohort Studies, Conscious Sedation, adverse effects, Critical Illness, mortality, Delirium, drug therapy, Dose-Response Relationship, Drug, Drug Administration Schedule, Evoked Potentials, Auditory, Brain Stem, physiology, Female, Glasgow Coma Scale, Humans, Hypnotics and Sedatives, administration & dosage, Infusions, Intravenous, Intensive Care, methods, Intensive Care Units, Logistic Models, Male, Mental Disorders, diagnosis, Midazolam, administration & dosage, Middle Aged, Multivariate Analysis, Neurologic Examination, methods, Predictive Value of Tests, Prospective Studies, Sufentanil, administration & dosage, Survival Analysis

Effect of a pharmacist-led multicomponent intervention focusing on the medication monitoring phase to prevent potential adverse drug events in nursing homes. Lapane KL, Hughes CM, Daiello LA, Cameron KA, Feinberg J Journal of the American Geriatrics Society 2011

Aged, Aged, 80 and over, Delirium, prevention & control, Drug Monitoring, Drug-Related Side Effects and Adverse Reactions, prevention & control, Female, Humans, Male, Monitoring, Physiologic, methods, Nursing Homes, organization & administration, Pharmacies, organization & administration, Pharmacists

Aripiprazole and haloperidol in the treatment of delirium. Boettger S, Friedlander M, Breitbart W, Passik S The Australian and New Zealand journal of psychiatry 2011

Adult, Aged, Antipsychotic Agents, therapeutic use, Databases, Factual, Delirium, diagnosis, Female, Haloperidol, therapeutic use, Humans, Male, Middle Aged, Piperazines, therapeutic use, Psychiatric Status Rating Scales, Quinolones, therapeutic use, Severity of Illness Index, Treatment Outcome

Frequency, risk factors, and prognosis of prolonged delirium in elderly patients after hip fracture surgery. Lee KH, Ha YC, Lee YK, Kang H, Koo KH Clinical orthopaedics and related research 2011

Age Factors, Aged, Aged, 80 and over, Arthroplasty, Replacement, Hip, adverse effects, Delirium, diagnosis, Female, Fracture Fixation, Internal, adverse effects, Hip Fractures, mortality, Humans, Kaplan-Meier Estimate, Logistic Models, Male, Republic of Korea, Risk Assessment, Risk Factors, Survival Rate, Time Factors, Treatment Outcome

Contextual factors influencing success or failure of emergency department interventions for cognitively impaired older people: a scoping and integrative review. Parke B, Beaith A, Slater L, Clarke AM Journal of advanced nursing 2011

Adult, Aged, Aged, 80 and over, Cognition Disorders, diagnosis, Delirium, epidemiology, Dementia, epidemiology, Developed Countries, statistics & numerical data, Emergency Service, Hospital, organization & administration, Geriatric Assessment, Health Facility Environment, organization & administration, Health Services for the Aged, organization & administration, Humans, Mass Screening, methods, Nurse’s Role, Outcome and Process Assessment (Health Care), Prevalence, Quality Improvement, Research Design, Risk Factors

Obstructive sleep apnea and incidence of postoperative delirium after elective knee replacement in the nondemented elderly. Flink BJ, Rivelli SK, Cox EA, White WD, Falcone G, Vail TP, Young CC, Bolognesi MP, Krystal AD, Trzepacz PT, Moon RE, Kwatra MM Anesthesiology 2012

Aged, Aged, 80 and over, Arthroplasty, Replacement, Knee, adverse effects, Delirium, diagnosis, Female, Humans, Incidence, Male, Postoperative Complications, diagnosis, Prospective Studies, Questionnaires, Sleep Apnea, Obstructive, complications, Surgical Procedures, Elective, adverse effects

Antipsychotic use and diagnosis of delirium in the intensive care unit. Swan JT, Fitousis K, Hall JB, Todd SR, Turner KL Critical care (London, England) 2012

Delirium

Length of stay

ICU delirium

Antipsychotics

The cholinergic system and inflammation: common pathways in delirium pathophysiology. Cerejeira J, Nogueira V, Luís P, Vaz-Serra A, Mukaetova-Ladinska EB Journal of the American Geriatrics Society 2012

Aged, Aged, 80 and over, Arthroplasty, Replacement, Hip, adverse effects, Biological Markers, blood, C-Reactive Protein, metabolism, Cholinesterases, blood, Cytokines, blood, Delirium, blood, Female, Follow-Up Studies, Humans, Inflammation, blood, Inflammation Mediators, blood, Male, Middle Aged, Postoperative Complications, Prognosis

Evidence-based treatment of delirium in patients with cancer. Breitbart W, Alici Y Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012

Adrenergic alpha-2 Receptor Agonists, therapeutic use, Antipsychotic Agents, adverse effects, Cholinesterase Inhibitors, therapeutic use, Delirium, diagnosis, Evidence-Based Practice, Humans, Neoplasms, psychology, Prevalence

Potential use of melatonin in sleep and delirium in the critically ill. Bellapart J, Boots R British journal of anaesthesia 2012

Central Nervous System Depressants, therapeutic use, Critical Illness, Delirium, complications, Humans, Intensive Care, methods, Intensive Care Units, Melatonin, therapeutic use, Risk Factors, Sleep, Sleep Deprivation, complications

Preoperative and operative predictors of delirium after cardiac surgery in elderly patients. Bakker RC, Osse RJ, Tulen JH, Kappetein AP, Bogers AJ European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2012

Aged, Aged, 80 and over, Biological Markers, blood, Cardiac Surgical Procedures, adverse effects, Creatinine, blood, Delirium, etiology, Extracorporeal Circulation, Female, Humans, Male, Preoperative Period, Prospective Studies, Psychiatric Status Rating Scales, Risk Factors, Treatment Outcome

Delirium superimposed on dementia: accuracy of nurse documentation. Steis MR, Fick DM Journal of gerontological nursing 2012

Aged, Aged, 80 and over, Delirium, complications, Dementia, complications, Documentation, Female, Humans, Male, Nursing Records

The impact of frailty and delirium on mortality in older inpatients. Eeles EM, White SV, O'Mahony SM, Bayer AJ, Hubbard RE Age and ageing 2012

Aged, Aged, 80 and over, Aging, psychology, Delirium, diagnosis, Female, Frail Elderly, psychology, Geriatric Assessment, Humans, Inpatients, psychology, Kaplan-Meier Estimate, Male, Prognosis, Proportional Hazards Models, Prospective Studies, Risk Assessment, Risk Factors, Time Factors, Wales, epidemiology

Validation of the Greek version of Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Adamis D, Dimitriou C, Anifantaki S, Zachariadis A, Astrinaki I, Alegakis A, Mari H, Tsiatsiotis N Intensive & critical care nursing : the official journal of the British Association of Critical Care Nurses 2012

Aged, Delirium, diagnosis, Female, Geriatric Assessment, Greece, Hospitalization, Humans, Intensive Care Units, Male, Middle Aged, Neuropsychological Tests, Prevalence

Postoperative complications: delirium. Allen SR, Frankel HL The Surgical clinics of North America 2012

Delirium, diagnosis, Diagnostic and Statistical Manual of Mental Disorders, Humans, Postoperative Complications, diagnosis

Palliative sedation in end-of-life care and survival: a systematic review. Maltoni M, Scarpi E, Rosati M, Derni S, Fabbri L, Martini F, Amadori D, Nanni O Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012

Case-Control Studies, Cause of Death, Cohort Studies, Female, Humans, Hypnotics and Sedatives, therapeutic use, Male, Neoplasms, drug therapy, Palliative Care, methods, Risk Assessment, Survival Analysis, Terminal Care, methods, Terminally Ill, Time Factors, Treatment Outcome

Development of a delirium risk screening tool for long-term care facilities. McCusker J, Cole MG, Voyer P, Ciampi A, Monette J, Champoux N, Vu M, Belzile E International journal of geriatric psychiatry 2012

Aged, Aged, 80 and over, Cohort Studies, Delirium, diagnosis, Female, Humans, Long-Term Care, Male, Mass Screening, methods, Quebec, Risk Factors

Sleep quality and its association with delirium among veterans enrolled in hospice. Slatore CG, Goy ER, Oʼhearn DJ, Boudreau EA, OʼMalley JP, Peters D, Ganzini L The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2012

Aged, Cohort Studies, Delirium, complications, Female, Hospice Care, statistics & numerical data, Humans, Male, Oregon, epidemiology, Prevalence, Risk Factors, Sleep Initiation and Maintenance Disorders, complications, Veterans, psychology

Evidence for the diagnostic criteria of delirium: an update. Blazer DG, van Nieuwenhuizen AO Current opinion in psychiatry 2012

Delirium, classification, Dementia, diagnosis, Diagnosis, Differential, Diagnostic and Statistical Manual of Mental Disorders, Humans, International Classification of Diseases

Delirium prevention in terminal cancer: assessment of a multicomponent intervention. Gagnon P, Allard P, Gagnon B, Mérette C, Tardif F Psycho-oncology 2012

Aged, Aged, 80 and over, Canada, epidemiology, Delirium, epidemiology, Female, Humans, Incidence, Intervention Studies, Length of Stay, Male, Middle Aged, Neoplasms, complications, Palliative Care, Patient Care Team, Risk Factors, Severity of Illness Index, Terminal Care, Terminally Ill, psychology

Using Diffusion of Innovations Theory to implement the confusion assessment method for the intensive care unit. Bowen CM, Stanton M, Manno M Journal of nursing care quality 2012

Confusion, nursing, Delirium, diagnosis, Diffusion of Innovation, Humans, Intensive Care, methods, Intensive Care Units, Nursing Assessment, methods, Nursing Evaluation Research, Psychological Theory, Sensitivity and Specificity

Psychiatric diagnosis in the elderly referred to a consultation-liaison psychiatry service in a general geriatric hospital in Japan. Yamada K, Hosoda M, Nakashima S, Furuta K, Awata S Geriatrics & gerontology international 2012

Aged, Aged, 80 and over, Delirium, diagnosis, Depression, diagnosis, Female, Geriatrics, Hospitals, General, Humans, Japan, Male, Mental Disorders, diagnosis, Psychiatric Department, Hospital, Referral and Consultation

Screening utility of the Montreal Cognitive Assessment (MoCA): in place of--or as well as--the MMSE? Larner AJ International psychogeriatrics / IPA 2012

Adult, Aged, Aged, 80 and over, Dementia, diagnosis, Female, Humans, Male, Mass Screening, statistics & numerical data, Mental Status Schedule, statistics & numerical data, Middle Aged, Mild Cognitive Impairment, diagnosis, Neuropsychological Tests, statistics & numerical data, Psychometrics, statistics & numerical data, ROC Curve, Reproducibility of Results, Statistics as Topic, Young Adult

The sound environment in an ICU patient room--a content analysis of sound levels and patient experiences. Johansson L, Bergbom I, Waye KP, Ryherd E, Lindahl B Intensive & critical care nursing : the official journal of the British Association of Critical Care Nurses 2012

Aged, Aged, 80 and over, Attitude to Health, Delirium, prevention & control, Female, Follow-Up Studies, Health Status, Humans, Intensive Care Units, Male, Mental Recall, Middle Aged, Noise, prevention & control, Patients’ Rooms, Sweden

Prior pathology in the basal forebrain cholinergic system predisposes to inflammation-induced working memory deficits: reconciling inflammatory and cholinergic hypotheses of delirium. Field RH, Gossen A, Cunningham C The Journal of neuroscience : the official journal of the Society for Neuroscience 2012

Animals, Cholinergic Neurons, metabolism, Delirium, metabolism, Encephalitis, metabolism, Female, Memory Disorders, metabolism, Mice, Mice, Inbred C57BL, Models, Neurological, Prosencephalon, metabolism

Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study. van den Boogaard M, Pickkers P, Slooter AJ, Kuiper MA, Spronk PE, van der Voort PH, van der Hoeven JG, Donders R, van Achterberg T, Schoonhoven L BMJ (Clinical research ed.) 2012

APACHE, Adult, Aged, Cohort Studies, Decision Support Techniques, Delirium, diagnosis, Female, Humans, Intensive Care, methods, Intensive Care Units, Male, Medical Staff, Hospital, Middle Aged, Models, Biological, Netherlands, Prognosis, Reproducibility of Results, Risk Factors, Sensitivity and Specificity

I-SAVE study: impact of sedation, analgesia, and delirium protocols evaluated in the intensive care unit: an economic evaluation. Awissi DK, Bégin C, Moisan J, Lachaine J, Skrobik Y The Annals of pharmacotherapy 2012

APACHE, Analgesia, economics, Analgesics, administration & dosage, Clinical Protocols, Cost-Benefit Analysis, Deep Sedation, economics, Delirium, economics, Humans, Hypnotics and Sedatives, administration & dosage, Intensive Care, economics, Intensive Care Units, economics, Length of Stay, economics, Male, Middle Aged, Prospective Studies, Respiration, Artificial, economics

Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Murray C, Sanderson DJ, Barkus C, Deacon RM, Rawlins JN, Bannerman DM, Cunningham C Neurobiology of aging 2012

Acute Disease, Animals, Delirium, pathology, Dementia, pathology, Disease Models, Animal, Female, Inflammation, complications, Inflammation Mediators, administration & dosage, Lipopolysaccharides, administration & dosage, Memory Disorders, pathology, Memory, Short-Term, physiology, Mice, Mice, Inbred C57BL

Poststroke delirium incidence and outcomes: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Mitasova A, Kostalova M, Bednarik J, Michalcakova R, Kasparek T, Balabanova P, Dusek L, Vohanka S, Ely EW Critical care medicine 2012

Adult, Aged, Aged, 80 and over, Cohort Studies, Confusion, classification, Delirium, diagnosis, Disease Progression, Female, Follow-Up Studies, Hospitals, University, Humans, Intensive Care, methods, Intensive Care Units, Male, Middle Aged, Neuropsychological Tests, Proportional Hazards Models, Prospective Studies, Reproducibility of Results, Risk Assessment, Severity of Illness Index, Statistics, Nonparametric, Stroke, diagnosis, Survival Rate

Haloperidol dosing strategies in the treatment of delirium in the critically ill. Wang EH, Mabasa VH, Loh GW, Ensom MH Neurocritical care 2012

Antipsychotic Agents, administration & dosage, Critical Illness, therapy, Delirium, drug therapy, Dose-Response Relationship, Drug, Drug Administration Schedule, Haloperidol, administration & dosage, Humans

Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial*. Wang W, Li HL, Wang DX, Zhu X, Li SL, Yao GQ, Chen KS, Gu XE, Zhu SN Critical care medicine 2012

Aged, Antipsychotic Agents, therapeutic use, Delirium, epidemiology, Double-Blind Method, Female, Haloperidol, therapeutic use, Humans, Incidence, Male, Postoperative Complications, epidemiology, Prospective Studies